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Clinical Endocrinology

Suna Kılınç, Enver Atay, Ömer Ceran, Zeynep Atay
CONTEXT: The effects of Vitamin D on reproductive function in adults have gained interest. Studies have demonstrated some associations. Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty. This HPG activation is important for future gonadal function. There is no data regarding the association of gonadal hormones and 25(OH)D levels at mini-puberty. Demonstration of any association would form the basis for studies that will search for the effects of 25(OH)D on gonadal hormones at mini-puberty...
September 19, 2018: Clinical Endocrinology
Mina Amiri, Razieh Bidhendi Yarandi, Fatemeh Nahidi, Maryam Tohidi, Fahimeh Ramezani Tehrani
BACKGROUND AND OBJECTIVE: While has been well demonstrated that clinical characteristics of polycystic ovary syndrome (PCOS) are associated with an impaired quality of life (QoL) in patients, it is unclear that whether the biochemical aspects of PCOS can influence their QoL. We aimed to investigate the relationship between clinical and biochemical characteristics, and various domains of QoL in patients with PCOS. DESIGN: A cross-sectional study. PATIENTS AND MEASUREMENTS: We assessed the association between clinical and biochemical characteristics and QoL domains (psychosocial-emotional, fertility, sexual function, and obesity-menstrual) in a total of 211 women with PCOS using a specific health related quality of life questionnaire for PCOS patients...
September 19, 2018: Clinical Endocrinology
Weiping Li, Qingfeng Chen, Yikai Xie, Jinbo Hu, Shumin Yang, Miaozhi Lin
OBJECTIVE: The euglycemic-hyperinsulinemic clamp is the gold standard to evaluate insulin resistance (IR), but there are only a few studies on the prevalence of IR in Chinese Han women with polycystic ovary syndrome (PCOS). This study investigated: 1) the prevalence of IR in Chinese Han women with PCOS by clamp, 2) the degree of reduction of insulin sensitivity (IS) and the contribution of body mass index (BMI). DESIGN: Retrospective cross-sectional analysis. PATIENTS: Chinese Han women with PCOS (n=448) visiting the Department of Endocrinology or the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Chongqing Medical University...
September 19, 2018: Clinical Endocrinology
Anastasios Serbis, Vasileios Giapros, Anna Challa, Nikolaos Chaliasos, Ekaterini Siomou
CONTEXT: Adults with plasma glucose levels at one hour (1h-GL) ≥8.6 mmol/L during an oral glucose tolerance test (OGTT) are at increased risk for type 2 diabetes mellitus and present an unfavorable cardiometabolic and inflammatory profile, but relevant data on children is scarce. OBJECTIVE: To investigate if elevated 1h-GL during OGTT in obese children and adolescents is associated with insulin resistance and specific pro-inflammatory biomarkers. RESEARCH DESIGN AND METHODS: The study group comprised 88 obese children who attended the Outpatient Pediatric Clinic of our Hospital between January and December 2016...
September 19, 2018: Clinical Endocrinology
Shiqian Hu, Yue Wang, Mingqian He, Meng Zhang, Xi Ding, Bingyin Shi
OBJECTIVE: Intravenous methylprednisolone (IVMP) is recommended as the first-line treatment for moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). This study aimed to identify potential predictors and establish a multivariable prediction model for the efficacy of IVMP therapy. DESIGN: A single-center retrospective study. PATIENTS: A total of 302 consecutive patients diagnosed with moderate-to-severe and active TAO who underwent the full course of IVMP therapy were included...
September 19, 2018: Clinical Endocrinology
Suttikarn Santiwatana, Pat Mahachoklertwattana, Chanin Limwongse, Patcharin Khlairit, Sarunyu Pongratanakul, Ekkapong Roothumnong, Kanjana Prangphan, Lulin Choubtum, Duantida Songdej, Preamrudee Poomthavorn
OBJECTIVE: Skewed X chromosome inactivation (XCI) was associated with female predominance in adult autoimmune thyroid disease (ATD). In normal females, skewed XCI is increased with age. Whether early-onset skewed XCI is associated with childhood ATD remains unknown. This study aimed to determine XCI skewing in paediatric ATD. DESIGN, PATIENTS AND MEASUREMENTS: Ninety-one female ATD patients, aged 3-20 years and 57 age-matched, female controls were enrolled. XCI was analysed by enzymatic digestion of DNA with methylation-sensitive enzymes followed by PCR of the polymorphic CAG repeat in the androgen receptor gene...
September 19, 2018: Clinical Endocrinology
Bo Hyun Kim, Seong-Jang Kim, Mijin Kim, Sang-Woo Lee, Shin Young Jeong, Kyoungjune Pak, Keunyoung Kim, In Joo Kim
OBJECTIVE: The purpose of the current study was to investigate the diagnostic performance of high mobility group A2 (HMGA2) gene expression for differentiation of malignant thyroid nodules through a systematic review and meta-analysis. DESIGN: The MEDLINE/PubMed and EMBASE database, from the earliest available date of indexing through April 10, 2018, were searched for studies evaluating the diagnostic performance of HMGA2 expression for differentiation of thyroid nodules...
September 17, 2018: Clinical Endocrinology
Pedro Marques, David Collier, Ariel Barkan, Márta Korbonits
Germline aryl hydrocarbon receptor-interacting protein (AIP) mutations are present in 15-30% of familial isolated pituitary adenoma (FIPA) families, and are responsible for 30% of pituitary gigantism cases (1). However, pathological accelerated growth and/or tall stature can be unrelated to the growth hormone (GH) axis, and may occur in isolation or as part of a syndrome, such as in Klinefelter, Marfan or Sotos syndromes (2). Here, we report a five-generation kindred with two brothers with pituitary gigantism due to AIP mutation-positive GH-secreting pituitary adenomas and their first-cousin coincidently also having gigantism due to Marfan syndrome (Figure 1)...
September 17, 2018: Clinical Endocrinology
Dimitra Magkou, Christine DoCao, Claire Bouvattier, Claire Douillard, Capucine de Marcellus, Laure Cazabat, Maxime Gérard, Marie-Laure Raffin-Sanson, Jacques Young
OBJECTIVE: Mitotane/o,p'DDD is used in the treatment of adrenocortical carcinoma and for other causes of hypercortisolism. Mitotane inhibits cortisol secretion and displays adrenolytic and antitumor actions. This compound is a metabolite of the pesticide and endocrine disruptor DDT (Dichlorodiphenyltrichloroethane) and is classified among teratogenic compounds worldwide. However, little is known about its effects on human development. DESIGN: The outcome of four children exposed to mitotane during their intrauterine life was examined...
September 17, 2018: Clinical Endocrinology
C N Jayasena, R Luo, A Dimakopoulou, C Dearing, H Clarke, N Patel, T Stroud, L Seyani, J Ramsay, W S Dhillo
BACKGROUND: Sperm cryopreservation (freezing) should be offered to all men with cancer due to risk of infertility. However, many men with cancer already have impaired spermatogenesis prior to sperm cryopreservation. Furthermore, physical ill-health may hinder attendance of freeze visits. Investigating both the distribution of sperm function and freeze attendance rates in men with newly diagnosed cancer, may identify patients benefiting from targeted reproductive fertility support. METHODS: We performed a retrospective study of 2906 male patients undergoing sperm cryopreservation prior to cancer therapy at a single UK tertiary centre between 1989 and 2013; all patients were asked to attend three hospital semen collection visits prior to cancer therapy...
September 11, 2018: Clinical Endocrinology
Matt Prior, Jane Stewart, Kevin McEleny, Andrew A Dwyer, Richard Quinton
Men with hypogonadotropic hypogonadism (HH) are typically azoospermic, and yet HH is one of the few treatable forms of male infertility. Sperm induction protocols using gonadotrophins aim to replicate the natural endocrine control of spermatogenesis. Previously virilised men with adult-onset HH and normal testicular volume respond well to monotherapy in which human chorionic gonadotrophin (hCG) acts as a long-acting LH-analogue stimulating spermatogenesis. However, this approach is rarely successful for men with congenital HH (CHH) (e...
September 8, 2018: Clinical Endocrinology
Karen Mullan, Chris Patterson, Katy Doolan, Jennifer Cundick, Lesley Hamill, Gareth McKeeman, Paul McMullan, Peter Smyth, Ian Young, Jayne V Woodside
OBJECTIVE: The re-emergence of iodine deficiency in the UK has recently been reported in a large cohort of teenage girls including from Northern Ireland (NI) using the gold standard spot urinary iodine concentration. We wished to explore and confirm this by analysing neonatal thyroid stimulating hormone (nTSH) levels in the NI population. DESIGN: We analysed the nTSH heel prick tests results from the NI national screening database between 2003 and 2014. The WHO propose a definition for population iodine sufficiency at <3% of the population with nTSH results >5 mIU/L...
September 5, 2018: Clinical Endocrinology
John F Aloia, Subhashini Katumuluwa, Alexandra Stolberg, Gianina Usera, Mageda Mikhail, Andrew N Hoofnagle, Shahidul Islam
OBJECTIVE: It is anticipated that an intake of vitamin D found acceptable by Endocrine Society Guidelines (10,000 IU/day) with co-administered calcium supplements may result in frequent hypercalciuria and hypercalcemia. This combination may be associated with kidney stones. The objective of this study was to compare the episodes of hypercalciuria and hypercalcemia from calcium supplements co-administered with 10,000 IU or 600 IU vitamin D daily. This design allows a comparison of the Institute of Medicine recommendation for the RDA of vitamin D along with the Upper Limit of calcium intake with the high intake of vitamin D suggested by the Endocrine Society...
September 4, 2018: Clinical Endocrinology
Wei Liu, Qian-Yue Zhang, Fei-Fei Yuan, Hai-Ning Wang, Le-Le Zhang, Yu-Ru Ma, Xiao-Ping Ye, Man-Man Zhang, Zhi-Yi Song, Sheng-Xian Li, Wen-Hua Du, Jun Liang, Xiao Mei Zhang, Guan Qi Gao, Shuang Xia Zhao, Feng-Ling Chen, Huai Dong Song
OBJECTIVE: we aimed to investigate the six susceptibility loci of GD identified from European population in Chinese Han population, and further to estimate the genetic heterogeneity of them in stratification of our GD patients. DESIGN: dense mapping studies based on GWAS. PATIENTS: 1,536 GD patients and 1,516 controls in GWAS stage and 1,994 GD patients and 2,085 controls and 5,033 GD patients and 5,389 controls in two replication stages. MEASUREMENTS: Based on our previous GWAS data, independently GD associated SNPs in each region were identified by TagSNP analysis and logistic regression analysis...
September 3, 2018: Clinical Endocrinology
Zheng Feei Ma
No abstract text is available yet for this article.
September 3, 2018: Clinical Endocrinology
Anastasia Ibba, Chiara Guzzetti, Letizia Casula, Mariacarolina Salerno, Natascia Di Iorgi, Anna Maria Elsa Allegri, Marco Cappa, Mohamad Maghnie, Sandro Loche
OBJECTIVE: The diagnosis of growth hormone deficiency (GHD) is currently based on clinical, auxological, biochemical, and neuro-radiological investigation. Provocative tests of GH secretion using physiological/pharmacological stimuli are required to confirm GHD. The clonidine test (CT) is widely used to assess GH secretory status. In this retrospective study, we analyzed the reliability of CT and the effect of puberty in a large number of children with short stature who had been evaluated for suspected GHD...
September 1, 2018: Clinical Endocrinology
Emily J Meyer, Marni A Nenke, Wayne Rankin, John G Lewis, Elisabeth Konings, Maarten Slager, Tim C Jansen, Jan Bakker, Johannes Hofland, Richard A Feelders, David J Torpy
CONTEXT: Corticosteroid-binding globulin (CBG) and albumin transport circulating cortisol. Cleavage of high affinity CBG (haCBG) by neutrophil elastase at inflammatory sites causes cortisol release into tissues, facilitating immunomodulatory effects. OBJECTIVE: To determine if depletion of haCBG is related to mortality in septic shock. DESIGN: A single center prospective observational cohort study of patients recruited with critical illness or septic shock, using serum samples collected at 0, 8, 24, 48 and 72 hours...
August 30, 2018: Clinical Endocrinology
Evangelos Grigoriou Sakkas, George Paltoglou, Anastasia Linardi, Alexandros Gryparis, Eleni Nteka, Nikos Chalarakis, Aimilia Mantzou, Nikolaos Vrachnis, Zoe Iliodromiti, Eftychia Koukkou, Efthymios Deligeoroglou, Grigorios Evangelou Sakkas, George Mastorakos
BACKGROUND: Thyroid physiology and autoimmunity are altered in pregnancy. While estradiol, cortisol and TGF-β1 are implicated in these phenomena outside pregnancy, their associations with thyroid autoantibodies during pregnancy and postpartum are not thoroughly examined. This study aimed to unravel their eventual associations during pregnancy and post-partum in the same cohort of 93 pregnant women studied prospectively from 2015 to 2017. METHODS: Blood samples were drawn at the 24th and the 36th gestational week and at the 1st postpartum week for measurements of thyroid hormones, TSH, anti-TPO, anti-Tg, estradiol, cortisol and TGF-β1...
August 27, 2018: Clinical Endocrinology
Kenji Obayashi, Yuki Yamagami, Junko Iwamoto, Norio Kurumatani, Keigo Saeki
OBJECTIVE: Reportedly, melatonin protects the pancreatic islets and decreases insulin resistance; thus, it may contribute to preventing diabetes. Epidemiological data suggested that lower melatonin secretion is associated with higher incidence of diabetes in female nurses. Such associations are unknown in the general population. We evaluated the association between melatonin secretion and diabetes in a general population, including both genders. DESIGN: Cross-sectional study...
August 27, 2018: Clinical Endocrinology
Thomas W Laver, Matthew N Wakeling, Janet Hong Yeow Hua, Jayne A L Houghton, Khalid Hussain, Sian Ellard, Sarah E Flanagan
OBJECTIVE: Hyperinsulinaemic hypoglycaemia (HH) can occur in isolation or more rarely feature as part of a syndrome. Screening for mutations in the "syndromic" HH genes is guided by phenotype with genetic testing used to confirm the clinical diagnosis. As HH can be the presenting feature of a syndrome, it is possible that mutations will be missed as these genes are not routinely screened in all newly diagnosed individuals. We investigated the frequency of pathogenic variants in syndromic genes in infants with HH who had not been clinically diagnosed with a syndromic disorder at referral for genetic testing...
August 23, 2018: Clinical Endocrinology
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