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Clinical Endocrinology

Maryam Razzaghy-Azar, Mitra Nourbakhsh, Mona Nourbakhsh
BACKGROUND: Cyproheptadine HCl (CyproH) is an appetite stimulating drug and while it was prescribed for a patient with growth hormone insensitivity syndrome (GHIS) for increasing appetite, his height growth was surprisingly increased. Therefore the aim of this study was to investigate the effect of CyproH on growth parameters of the patients with GHIS. PATIENTS AND DESIGN: Twenty patients were enrolled in two prospective cohorts at two different times. Fifteen cases were observed for 1...
March 9, 2018: Clinical Endocrinology
L Underbjerg, T Sikjaer, L Rejnmark
OBJECTIVE: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (PHP) are rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively. Only few studies on Quality of Life (QoL) among patients with Ns-HypoPT and PHP are available. We aimed to investigate the QoL among patients with Ns-HypoPT and PHP including information about education. DESIGN: A cohort study with patients identified from a previously epidemiological study. PATIENTS: 57 patients with Ns-HypoPT and 30 patients with PHP...
March 9, 2018: Clinical Endocrinology
Leandro Kasuki, Marilia Duarte Dalmolin, Luiz Eduardo Armondi Wildemberg, Mônica R Gadelha
BACKGROUND: Few studies evaluated the use of cabergoline (CAB) for acromegaly treatment in monotherapy or in combination with first-generation somatostatin receptor ligands (SRLs). AIM: Evaluate the efficacy, predictors of response and safety of CAB treatment in acromegaly both in monotherapy and in combination with SRLs. METHODS: We retrospectively collected demographic, biochemical, tumor and treatment data. Short-term disease control was defined as random GH level <1...
March 9, 2018: Clinical Endocrinology
Yang Yu, Nan Yu, Guizhi Lu, Ting Li, Yang Zhang, Jing Zhang, Ying Gao, Yanming Gao, Xiaohui Guo
BACKGROUND: Hashimoto's thyroiditis (HT) with serum IgG4 concentrations greater than 135 mg/dl can be diagnosed as elevated serum IgG4 HT. HT can also be classified into IgG4 HT and non-IgG4 HT based on an immunohistochemistry analysis of IgG4. The aim of our study was to determine the relationship between elevated serum IgG4 HT and IgG4 HT. METHOD: 93 HT patients with both thyroid tissues and serum samples stored before pathological examination were collected. The serum levels of IgG, IgG4, TgAb IgG, TgAb IgG4, TPOAb IgG, and TPOAb IgG4 were measured by ELISAs...
March 9, 2018: Clinical Endocrinology
Mijin Kim, Minkyu Han, Jeong Hyun Lee, Dong Eun Song, Kyunggon Kim, Jung Hwan Baek, Young Kee Shong, Won Gu Kim
OBJECTIVE: Distinguishing malignancy from benign thyroid nodule has always been challenging, especially in follicular lesions. Thyroid nodules with small size and indeterminate cytology do not lead to immediate surgery. We tried to evaluate whether tumor size and tumor growth rate can distinguish follicular thyroid carcinoma (FTC) from follicular adenoma (FA). DESIGN AND PATIENTS: This retrospective study included patients with pathologically proven FTCs (n=50) and FAs (n=110) who underwent preoperative serial neck ultrasonography (US) at least 3 times: it comprises 30% of all follicular tumors (32% FAs and 25% FTCs)...
March 6, 2018: Clinical Endocrinology
Yan Han, Lei-Jing Mao, Xing Ge, Kun Huang, Shuang-Qin Yan, Ling-Ling Ren, Shu-Qing Hong, Hui Gao, Jie Sheng, Yuan-Yuan Xu, Wei-Jun Pan, Peng Zhu, Jia-Hu Hao, De-Fa Zhu, Fang-Biao Tao
OBJECTIVE: Hypertensive disorders of pregnancy (HDP) have been associated with adverse health outcomes for both mothers and children. Previous studies examining associations of maternal thyroid autoantibodies with HDP indicate conflicting results. The objective of this study was to examine associations of maternal thyroid autoantibodies positivity in the first and the second trimesters with the risk of HDP. DESIGN, PARTICIPANTS AND MEASUREMENTS: In the Ma'anshan Birth Cohort study, a population-based prospective study in China, a total of 3474 pregnant women were enrolled between May 2013 and September 2014...
March 5, 2018: Clinical Endocrinology
Serkan Yener, Mustafa Secil, Omer Demir, Basak Ozgen, Kutsal Yorukoglu
CONTEXT: To investigate whether any association between chemical shift magnetic resonance (MRI) findings, cortisol secretion and pathological findings exist that could predict subclinical hypercortisolism (SCH) in patients with adrenal incidentalomas (AI). DESIGN: Retrospective, cross sectional study in a tertiary centre. PATIENTS: Sixty-eight subjects with AIs and 13 patients with Cushing's syndrome (CS). Patients with AIs were categorized according to cortisol levels post 1mg dexamethasone (post-DST)...
March 1, 2018: Clinical Endocrinology
J Böker, H Völzke, M Nauck, A Hannemann, N Friedrich
OBJECTIVE: Growth hormone (GH) and its main mediator, insulin-like growth factor-I (IGF-I) play a significant role in bone metabolism. The relations between IGF-I and bone mineral density (BMD) or osteoporosis have been assessed in previous studies but whether the associations are sex-specific remains uncertain. Moreover, only few studies examined bone quality assessed by quantitative ultrasound (QUS). We aimed to investigate these associations in the general population of northeast Germany...
March 1, 2018: Clinical Endocrinology
Martin Miner, Abraham Morgentaler, Mohit Khera, Abdulmaged M Traish
OBJECTIVE: A label change for testosterone (T) products in March 2015 followed a highly-publicized FDA advisory committee meeting in September 2014. Changes included a warning of possible increased cardiovascular (CV) risks and restriction of indicated populations to younger men with a limited set of known etiologies of testosterone deficiency (TD). These changes greatly impacted clinical practice and public perception of T therapy (TTh). Our aim was to review these changes in light of subsequently published studies...
February 27, 2018: Clinical Endocrinology
Michael Conall Dennedy
In this issue of Clinical Endocrinology, Elder et al demonstrate the profile of salivary cortisol and cortisone following synacthen administration. Using a dexamethasone-induced model of adrenocortical insufficiency in healthy males, their data demonstrate the kinetics of serum cortisol paired with salivary cortisol and cortisone following both low (1mcg) and conventional dose (250mcg) synacthen. Peak serum cortisol occurred at 30 minutes following 1mcg synacthen, and serum cortisol continued to rise at 120 minutes following the 250mcg dose...
February 27, 2018: Clinical Endocrinology
Hironobu Umakoshi, Tatsuki Ogasawara, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamto, Atsushi Ogo, Toshihiko Yanase, Shintaro Okamura, Shozo Miyauchi, Tomoko Suzuki, Mika Tsuiki, Mitsuhide Naruse
CONTEXT: The current Endocrine Society Guideline suggests that patients aged <35 years with marked primary aldosteronism (PA) and unilateral adrenal lesions on adrenal computed tomography (CT) scan may not need adrenal vein sampling (AVS) before proceeding to unilateral adrenalectomy. This suggestion is, however, based on the data from only one report in the literature. OBJECTIVE: We sought to determine the accuracy of CT findings in young PA patients who had unilateral adrenal disease on CT with hypokalaemia and elevation of aldosterone...
February 21, 2018: Clinical Endocrinology
Lucía Sentchordi-Montané, Miriam Aza-Carmona, Sara Benito-Sanz, Ana C Barreda-Bonis, Consuelo Sánchez-Garre, Pablo Prieto-Matos, Pablo Ruiz-Ocaña, Alfonso Lechuga-Sancho, Atilano Carcavilla-Urquí, Inés Mulero-Collantes, Gabriel A Martos-Moreno, Angela Del Pozo, Elena Vallespín, Amaka Offiah, Manuel Parrón-Pajares, I Dinis, Sergio B Sousa, Purificación Ros-Pérez, Isabel González-Casado, Karen E Heath
OBJECTIVE: Mutations in the aggrecan gene (ACAN) have been identified in two autosomal dominant skeletal dysplasias, Spondyloepiphyseal dysplasia, Kimberley type (SEDK) and osteochondritis dissecans, as well as in a severe recessive dysplasia, Spondyloepimetaphyseal dysplasia, aggrecan type. Next generation sequencing (NGS) has aided the identification of heterozygous ACAN mutations in individuals with short stature, minor skeletal defects and mild facial dysmorphisms, some of whom have advanced bone age (BA), poor pubertal spurt and early growth cessation as well as precocious osteoarthritis...
February 21, 2018: Clinical Endocrinology
Gerdi Tuli, Daniele Tessaris, Silvia Einaudi, Patrizia Matarazzo, Luisa de Sanctis
OBJECTIVE: Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age...
February 21, 2018: Clinical Endocrinology
Arrate Pereda, Jose Maria Martos-Tello, Intza Garin, Javier Errea-Dorronsoro, Guiomar Perez de Nanclares
Progressive osseous heteroplasia (POH, OMIM#166350) is an "ultrarare" genetic condition characterized by plaque-like heterotopic ossification, beginning in infancy in the dermis and subsequently progressing to involve deep connective tissues such as muscles and joints, sometimes resulting in loss of mobility1 . It is usually associated with paternal inheritance of an inactivating mutation at the GNAS gene but in some patients (around 30% of cases) with identical clinical characteristics of POH no mutations have been detected2 ...
February 21, 2018: Clinical Endocrinology
Alyssa Halper, Belen Sanchez, James S Hodges, Aaron S Kelly, Donald Dengel, Brandon M Nathan, Anna Petryk, Kyriakie Sarafoglou
BACKGROUND: Children with congenital adrenal hyperplasia (CAH) are exposed to fluctuating cortisol and androgen levels. The effects these hormonal states have on bone mineral density (BMD) and body composition are not well studied. OBJECTIVE: Compare BMD and body composition, including visceral adipose tissue (VAT) and Android:Gynoid (A:G) ratio, in children with CAH vs. healthy age-, sex-, and BMI-matched controls. METHODS: Forty-two cases with CAH (average age 12...
February 20, 2018: Clinical Endocrinology
Malcolm Prentice
Diabetes Insipidus (DI) is a name given historically to two conditions, which result in 'diabetes', which is Greek for 'syphon' or polyuria. The "Insipidus" refers to urine being insipid. 'Cranial DI' is so called because it relates to a cause within the head characterised by deficiency of vasopressin [antidiuretic hormone (ADH)] secretion from the posterior pituitary. Treatment is with desmopressin, a synthetic long-acting analogue of vasopressin. In contrast 'Nephrogenic DI' is due to resistance of the renal tubules to vasopressin action...
February 20, 2018: Clinical Endocrinology
Mahnaz Bahri Khomami, Jacqueline A Boyle, Chau T Tay, Eszter Vanky, Helena J Teede, Anju E Joham, Lisa J Moran
Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication...
February 20, 2018: Clinical Endocrinology
Nicholas Thomas, John Glod, Claudia Derse-Anthony, Emma L Baple, Nigel Obsborne, Rachel Sturley, Bijay Vaidya, Kate Newbold, Antonia Brooke
Vandetanib is a tyrosine kinase inhibitor (TKI) used in the treatment of medullary thyroid carcinoma occurring in >95% of patients with multiple endocrine neoplasia type 2b (MEN 2b). Pregnancy in women with MEN 2b on vandetanib is previously unreported and has multiple potential implications for both the mother and developing fetus [1]. We describe the case of a 22 year old woman with a background of MEN 2b who was first diagnosed aged 6 presenting with marfanoid habitus, and oral mucosal neuromas. This article is protected by copyright...
February 19, 2018: Clinical Endocrinology
Yeqing Gu, Yanyan Wang, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Honglei Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
OBJECTIVE: Thyroid hormones (THs) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed the association between THs and metabolic syndrome (MetS) in a general population. We therefore designed a cohort study to examine whether serum THs levels within the reference range are predictive factors for developing MetS in adults. DESIGN: Prospective cohort study. PARTICIPANTS: A prospective study (n=6,119) was performed in Tianjin, China...
February 17, 2018: Clinical Endocrinology
Marta Hernández, Carolina López, Berta Soldevila, Laura Cecenarro, María Martínez-Barahona, Elisabet Palomera, Ferran Rius, Albert Lecube, Maria José Pelegay, Jordi García, Dídac Mauricio, Manel Puig Domingo
OBJECTIVE: An association of pregnancy outcomes with subclinical hypothyroidism has been reported, however there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The objective of the study was to evaluate the association of fetal-maternal complications with first trimester maternal TSH values. DESIGN: A retrospective study in a single tertiary care hospital was performed. PATIENTS: 1981 pregnant women were studied during 2012...
February 17, 2018: Clinical Endocrinology
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