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Clinical Endocrinology

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https://www.readbyqxmd.com/read/28640938/obstructive-sleep-apnoea-and-polycystic-ovary-syndrome-a-comprehensive-review-of-clinical-interactions-and-underlying-pathophysiology
#1
REVIEW
Hassan Kahal, Ioannis Kyrou, Abd A Tahrani, Harpal S Randeva
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. PCOS is associated with multiple co-morbidities including, obesity, insulin resistance and type 2 diabetes, as well as mood disorders and impaired quality of life (QoL). Obstructive sleep apnoea (OSA) is also a common medical condition that is often undiagnosed, particularly in women. OSA is associated with a similar spectrum of comorbidities to that observed in PCOS, including manifestations of the metabolic syndrome and impaired QoL, whilst obesity frequently constitutes a common denominator in the pathophysiology of both OSA and PCOS...
June 22, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28636775/role-of-the-tumour-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-fibroblast-growth-factor-inducible-14-fn14-axis-in-autoimmune-thyroid-disease
#2
Shiqiao Peng, Xiaohui Yu, Xuemin Zhao, Xinyi Wang, Xuren Sun, Cheng Han, Zhongyan Shan, Chenyan Li, Weiping Teng
BACKGROUND: TNF-like weak inducer of apoptosis (TWEAK), its receptor fibroblast growth factor-inducible 14 (Fn14) and its scavenger receptor CD163 (sCD163) have known associations with many autoimmune diseases. However, the role of the TWEAK axis in autoimmune thyroid disease (AITD) remains unclear. Therefore, the aim of this study was to investigate the role of the TWEAK-Fn14 axis in the pathogenesis of AITD. METHODS: Serum levels of soluble TWEAK (sTWEAK) and sCD163 were measured in 38 patients with Graves' disease (GD), 40 patients with Hashimoto's thyroiditis (HT), and 40 healthy controls (HCs)...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28636750/comparison-of-serum-vaspin-levels-and-vaspin-expression-in-adipose-tissue-and-smooth-muscle-tissue-in-pregnant-women-with-and-without-gestational-diabetes
#3
Yuping Tang, Ping Qiao, Xiaoxian Qu, Yirong Bao, Yuhong Li, Yini Liao, Hao Ying
OBJECTIVE: Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains unclear. This study aimed to compare circulating vaspin levels and its expression in different insulin target tissues including subcutaneous adipose tissue (SAT), VAT, and smooth muscle tissue (SMT) in pregnant women with and without GDM...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28626987/prolactinomas-diagnosed-in-the-postmenopausal-period-clinical-phenotype-and-outcomes
#4
Sandhya Santharam, Metaxia Tampourlou, Wiebke Arlt, John Ayuk, Neil Gittoes, Andrew Toogood, Rachel Webster, Niki Karavitaki
OBJECTIVE: Most prolactinomas in females are diagnosed during the reproductive age and the majority are microadenomas. Prolactinomas detected in the postmenopausal period are less common with limited published data on their presentation and prognosis. Our objective was to assess the presenting clinical, biochemical and imaging findings, as well as the outcomes of women diagnosed with a prolactinoma in the postmenopausal period. DESIGN AND METHODS: We undertook a retrospective cohort study of women diagnosed with prolactinoma after menopause and followed-up in a large UK pituitary center...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28626957/graves-disease-with-severe-neutropenia-any-clues
#5
Mohamed Osama Hegazi, Ammar Almansour, Abdallah Nawara
In volume 85, issue 6 of "Clinical Endocrinology", Aggarwal, et al. published a study titled "Treatment of Hyperthyroidism With Antithyroid Drugs Corrects Mild Neutropenia in Graves' Disease". The authors treated Graves' disease (GD) with mild neutropenia using a thionamide anti-thyroid drug (ATD). From that study we conclude that neutropenia is not uncommon in association with GD and accounts for 14% of cases, and that mild neutropenia does not preclude the use of ATDs. This article is protected by copyright...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28626954/isolated-growth-hormone-deficiency-due-to-the-r183h-mutation-in-gh1-clinical-analysis-of-a-four-generation-family
#6
Catalina Cabrera-Salcedo, Amy S Shah, Melissa Andrew, Leah Tyzinski, Vivian Hwa, Iris Gutmark-Little, Philippe Backeljauw, Andrew Dauber
The R183H mutation in the growth hormone gene (GH1) is a well-described genetic variant that causes autosomal dominant isolated growth hormone deficiency (IGHD) type II. Previous studies have demonstrated that individuals with this mutation have releasable growth hormone (GH) stores, but such release is severely impaired. Hess et al. reported variable height deficits (-4.5 to -1.0 SDS), variable IGF-I concentrations (-2.9 to -0.8 SDS), and low but detectable, or even normal stimulated peak GH in several patients with the R183H mutation...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28626928/predictors-for-secondary-therapy-after-surgical-resection-of-non-functioning-pituitary-adenomas
#7
Jeyakantha Ratnasingam, Nele Lenders, Benjamin Ong, Samuel Boros, Anthony W Russell, Warrick J Inder, Ken Ky Ho
CONTEXT: Factors determining recurrence of non-functioning pituitary adenomas (NFAs) that require further therapy are unclear as are post-operative follow-up imaging guidelines OBJECTIVE: To identify predictors for secondary therapy after surgical resection of NFAs and use this knowledge to inform post-operative management DESIGN AND PATIENTS: A single-centre retrospective study of surgically resected NFAs in 108 patients followed for up to 15 years. MEASUREMENTS: Serial tumour images were analysed for size, location and growth rate (GR) and tissue analysed for hormone cell type and proliferation indices with secondary treatment as outcome measure...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28626863/prolactin-correction-for-adequacy-of-petrosal-sinus-cannulation-may-diminish-diagnostic-accuracy-in-cushing-s-disease
#8
Sunita Mc De Sousa, Ann I McCormack, Shaun McGrath, David J Torpy
OBJECTIVE: Petrosal venous prolactin concentrations have been promoted to improve the diagnostic accuracy of inferior petrosal sinus sampling (IPSS), beyond that achieved with ACTH measurement alone, in diagnosing a pituitary ACTH source, and determining corticotrophinoma side (L/R). Our objective was to assess the effect of using prolactin to confirm adequacy of petrosal cannulation in a cohort of patients with ACTH-dependent Cushing's syndrome. DESIGN: Retrospective cohort study...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28618022/utility-of-a-formatted-pathologic-reporting-system-in-thyroid-core-needle-biopsy-a-validation-study-of-1998-consecutive-cases
#9
Ji-Young Choe, Yoonjin Kwak, Mimi Kim, Yul Ri Chung, Hyun Jeong Kim, Yeo Koon Kim, So Yeon Park
OBJECTIVE: Thyroid core needle biopsy (CNB) is increasingly being used as a tool for evaluating thyroid nodules; thus, standardization of its diagnostic terminology is called for. We aimed to analyze the pathologic reporting system of thyroid CNB based on the recently proposed protocol by the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group and evaluate its usefulness. DESIGN/METHODS: 1998 consecutive cases of thyroid CNBs were reviewed and divided into 6 categories according to the protocol...
June 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28617986/a-novel-hsd17b3-gene-mutation-in-a-46-xy-female-phenotype-newborn-identified-by-whole-exome-sequencing
#10
Rita Bertalan, Osnat Admoni, Anu Bashamboo, Yardena Tenenbaum-Rakover, Kenneth McElreavey
Deficiency of 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) enzyme encoded by HSD17B3 is a rare cause of disorders of sexual development (DSD). Mutations in this gene in 46,XY individuals present at birth with external female phenotype or ambiguous genitalia. The diagnosis of 46,XY DSD is very challenging and not rarely is confirmed only at older ages. This article is protected by copyright. All rights reserved.
June 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28617979/the-turner-syndrome-life-course-project-karyotype-phenotype-analyses-across-the-lifespan
#11
Antoinette Cameron-Pimblett, Clementina La Rosa, Thomas F J King, Melanie C Davies, Gerard S Conway
INTRODUCTION: Turner Syndrome is associated with a variety of morbidities affecting nearly every body system, some of which increase in prevalence in adult life. The severity of clinical features in TS is roughly in parallel with the magnitude of the deficit of X chromosome material. The aim of this study was to extend the established karyotype phenotype relationships using data from a large adult cohort. MATERIALS & METHODS: Karyotypes were available in 656 (78...
June 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28617975/incidence-of-parathyroid-disorders-in-an-indian-adult-male-population-a-25-year-follow-up-study
#12
K V S Hari Kumar, S K Patnaik
CONTEXT AND OBJECTIVE: Detailed information on the epidemiology of parathyroid disorders in India is lacking. Most of the available data pertain to primary hyperparathyroidism (PHPT) rather than the overall burden of parathyroid disorders. We studied the incidence of parathyroid disorders in a cohort of service personnel followed for a long duration. DESIGN, SETTING AND PATIENTS: The data for this retrospective, descriptive epidemiological study were derived from the electronic medical records (EMR) of health care personnel enrolled between 1990 and 2015...
June 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28609552/thyrotropin-levels-and-coronary-artery-calcification-cross-sectional-results-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#13
Érique José F Peixoto de Miranda, Márcio Sommer Bittencourt, Henrique Lane Staniak, Alexandre C Pereira, Murilo Foppa, Itamar S Santos, Paulo A Lotufo, Isabela M Bensenor
BACKGROUND: There is little information about the association between thyrotropin (TSH) levels and coronary artery calcification (CAC). OBJECTIVE: Our aim was to analyze the association between TSH quintiles and subclinical atherosclerosis measured by CAC, using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). DESIGN: Cross-sectional study. PATIENTS AND MEASUREMENTS: We excluded individuals using medications that affect thyroid function and who self-reported cardiovascular disease...
June 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28605116/phaeochromocytoma-in-multiple-endocrine-neoplasia-type-2-ret-codon-specific-penetrance-and-changes-in-management-during-the-last-four-decades
#14
L Mucha, G Leidig-Bruckner, K Frank-Raue, Th Bruckner, M Kroiss, F Raue
OBJECTIVES: We describe phaeochromocytoma penetrance in multiple endocrine neoplasia type 2 (MEN2) according to RET protooncogene-specific mutations, and report changes in phaeochromocytoma diagnosis and management from 1968 to 2015. DESIGN: This retrospective chart review included 309 MEN2 patients from one specialised ambulatory care centre. Phaeochromocytoma patients were categorised by diagnosis date: early, 1968-1996, n = 40; and recent, 1997-2015, n = 45. RESULTS: Phaeochromocytoma was diagnosed in 85/309 patients with RET mutations in the following exons (phaeos/all carriers, %): exon 11 (56/120, 46·6%); exon 16 (7/17, 41·2%), exon 10 (14/47, 29·8%), and exon 13-15 (2/116, 1·7%)...
June 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28590513/diagnostic-accuracy-of-increased-urinary-cortisol-cortisone-ratio-to-differentiate-acth-dependent-cushing-s-syndrome
#15
Filippo Ceccato, Laura Trementino, Mattia Barbot, Giorgia Antonelli, Mario Plebani, Luca Denaro, Daniela Regazzo, Federico Rea, Anna Chiara Frigo, Carolina Concettoni, Marco Boscaro, Giorgio Arnaldi, Carla Scaroni
BACKGROUND AND AIM: Differential diagnosis between Cushing's Disease (CD) and Ectopic ACTH Syndrome (EAS) may be a pitfall for endocrinologists. The increasing use in clinical practice of chromatography and mass spectrometry improves the measurement of urinary free cortisol (UFF) and cortisone (UFE). We have recently observed that cortisol to cortisone ratio (FEr) was higher in a small series of EAS; in this paper we collected a larger number of ACTH-dependent CS to study the role of FEr to characterize the source of corticotropin secretion...
June 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28585717/a-meta-analysis-of-intraoperative-neuromonitoring-of-recurrent-laryngeal-nerve-palsy-during-thyroid-reoperations
#16
Wei Sun, Jinhao Liu, Hao Zhang, Ping Zhang, Zhihong Wang, Wenwu Dong, Liang He, Ting Zhang
BACKGROUND: The rate of recurrent laryngeal nerve (RLN) palsy, a common complication of thyroid surgery, is especially high in thyroid reoperations. The present meta-analysis assesses whether intraoperative neuromonitoring (IONM) reduces the prevalence of RLN palsy in thyroid reoperations. DESIGN AND METHODS: A systematic literature search was conducted in the PubMed, SCIE, and Wan Fang databases for studies published up to August 31, 2016. All data were analysed using STATA (version 11) software...
June 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28581026/cross-sectional-association-between-testosterone-sex-hormone-binding-globulin-and-metabolic-syndrome-the-healthy-twin-study
#17
Heesun Moon, Inyoung Choi, Somi Kim, Hyeonyoung Ko, Jinyoung Shin, Kayoung Lee, Joohon Sung, Yun-Mi Song
OBJECTIVES: This study evaluated an association between testosterone, sex hormone-binding globulin (SHBG) and metabolic syndrome (MetS).We also evaluated the genetic and environmental influence on the association. DESIGN: Cross-sectional. SETTING: Community-based study. PARTICIPANTS: A total of 1,098 Korean adult men including 139 monozygotic twin pairs. MAIN OUTCOME MEASURE: MetS was defined using the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATP III) and International Diabetes Federation (IDF) criteria...
June 5, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28575537/association-between-biochemical-hyperandrogenism-parameters-and-ferriman-gallwey-score-in-patients-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-regression-analysis
#18
Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Razieh Bidhendi Yarandi, Samira Behboudi-Gandevani, Fereidoun Azizi
BACKGROUND AND OBJECTIVE: A limited number of studies have evaluated the relationship between clinical and biochemical hyperandrogenism (HA). This study aimed to evaluate the association between biochemical hyperandrogenism parameters (BHPs) and Ferriman-Gallwey (FG) score in patients with polycystic ovary syndrome (PCOS). METHODS: We searched PubMed, Scopus, Google Scholar, ScienceDirect and Web of Sciences databases (2000 to 2015) to identify studies investigating clinical and biochemical parameters of HA in PCOS patients...
June 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28574597/mortality-rates-are-lower-in-siad-than-in-hypervolaemic-or-hypovolaemic-hyponatraemia-results-of-a-prospective-observational-study
#19
Martín Cuesta, Aoife Garrahy, David Slattery, Saket Gupta, Anne Marie Hannon, Karen McGurren, Mark Sherlock, William Tormey, Christopher J Thompson
OBJECTIVE: Hyponatremia is associated with increased mortality, but the mortality associated specifically with SIAD is not known. We hypothesised that mortality in SIAD was elevated, but that it was less than in hypervolemic(HEN) or hypovolemic(HON) hyponatremia. DESIGN: Mortality rates are presented as risk ratios(RR),with 95% confidence intervals (CI), and compared to normonatremic controls(NN). METHODS: Prospective, single center, non-interventional study of all patients with hyponatremia(≤ 130 mmol/l) admitted to hospital...
June 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28561278/the-effects-of-testosterone-on-body-composition-in-obese-men-are-not-sustained-after-cessation-of-testosterone-treatment
#20
Mark Ng Tang Fui, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann
BACKGROUND: Testosterone treatment in obese dieting men augments the diet-associated loss of fat mass, but protects against loss of lean mass. We assessed whether body composition changes are maintained following withdrawal of testosterone treatment. METHODS: We conducted a pre-specified double-blind randomised placebo-controlled observational follow-up study of a randomized controlled trial (RCT). Participants were men with baseline obesity (body mass index ≥ 30kg/m(2) ) and a repeated total testosterone level ≤ 12nmol/L, previously enrolled in a 56-week testosterone-treatment trial combined with a weight loss program...
May 31, 2017: Clinical Endocrinology
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