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Clinical Endocrinology

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https://www.readbyqxmd.com/read/27914217/hla-g-3-untranslated-region-polymorphic-sites-associated-with-increased-hla-g-production-are-more-frequent-in-patients-exhibiting-differentiated-thyroid-tumors
#1
Nathalie Lobo de Figueiredo-Feitosa, Gustavo Martelli Palomino, Daiani Cristina Cilião Alves, Celso Teixeira Mendes Junior, Eduardo Antonio Donadi, Léa Maria Zanini Maciel
BACKGROUND: HLA-G is a non-classical class I histocompatibility molecule implicated on the immune escape mechanism of tumor cells. We evaluated the genetic diversity of HLA-G 3' untranslated region (3'UTR) and associated polymorphic sites with clinical presentation and with the magnitude of HLA-G thyroid expression. PATIENTS AND METHODS: Polymorphic sites at 3'UTR (14bpINS/DEL, +3003C/T, +3010C/G, +3027A/C, +3035C/T, +3142C/G, +3187A/G, +3196C/G) were characterized by sequencing analyses in blood samples of 72 patients exhibiting papillary thyroid carcinoma (PTC), 22 follicular thyroid carcinomas (FTC), 19 follicular adenomas (FA), 21 colloid goiters and 156 healthy controls...
December 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27911471/the-effects-of-coenzyme-q10-supplementation-on-glucose-metabolism-and-lipid-profiles-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#2
Mansooreh Samimi, Maryam Zarezade Mehrizi, Fatemeh Foroozanfard, Hossein Akbari, Mehri Jamilian, Shahnaz Ahmadi, Zatollah Asemi
BACKGROUND: Data on the effects of coenzyme Q10 (CoQ10) supplementation on metabolic profiles among subjects with polycystic ovary syndrome (PCOS) are scarce. OBJECTIVE: This study was done to evaluate the effects of CoQ10 supplementation on glucose metabolism and lipid profiles in subjects with PCOS. DESIGN, PATIENTS AND MEASUREMENTS: This randomized double-blind, placebo-controlled trial was conducted on 60 women diagnosed with PCOS. Subjects were randomly assigned into two groups to intake either 100 mg CoQ10 supplements (N=30) or placebo (N=30) per day for 12 weeks...
December 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27896825/is-it-time-to-reconsider-lobectomy-in-low-risk-paediatric-thyroid-cancer
#3
Wouter P Kluijfhout, Jesse D Pasternak, Danielle van der Kaay, Menno R Vriens, Evan J Propst, Jonathan D Wasserman
OBJECTIVE: Current guidelines recommend total thyroidectomy for nearly all children with well-differentiated thyroid cancer (WDTC). These guidelines, however, derive from older data accrued prior to current high-resolution imaging. We speculate that there is a sub-population of children who may be adequately treated with lobectomy. DESIGN: Retrospective analysis of prospectively maintained database. PATIENTS: 73 children with WDTC treated between 2004 and 2015...
November 29, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27874199/glucose-and-lipids-levels-with-lanreotide-autogel-120-mg-in-treatment-na%C3%A3-ve-patients-with-acromegaly-data-from-the-primarys-study
#4
Philippe J Caron, Stephan Petersenn, Aude Houchard, Caroline Sert, John S Bevan
OBJECTIVE: Impaired glycaemic control, characteristic of acromegaly, can be exacerbated by treatment with somatostatin analogues (SSAs), particularly those with multireceptor activity. We present data from the PRIMARYS study on the impact of the SSA lanreotide, associated with tumour volume and hormonal improvements, on glucose and other metabolic parameters in acromegaly. DESIGN: PRIMARYS was a 48-week open-label single-arm phase-3b study of lanreotide autogel 120mg/4 weeks...
November 22, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27864838/preoperative-alpha-blockade-in-phaeochromocytoma-and-paraganglioma-is-it-always-necessary
#5
Michelle Isaacs, Paul Lee
Resection of phaeochromocytoma and paraganglioma (PPGL) is traditionally preceded by alpha-blockade to prevent complications of haemodynamic instability intraoperatively. While there is general agreement on preoperative alpha-blockade for classic PPGLs presenting with hypertension, it is less clear whether alpha-blockade is necessary in predominantly dopamine-secreting tumours, normotensive PPGLs, as well as tumours that appear to be biochemically "silent". Preoperative management of these "atypical" PPGLs is challenging and the treatment approach must be individualised, carefully weighing the risk of intraoperative hypertension against the possibility of orthostatic and prolonged postoperative hypotension...
November 19, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27864986/urinary-iodine-excretion-uie-estimated-by-iodine-creatinine-ratio-from-spot-urine-in-chinese-school-age-children
#6
Wen Chen, Xiang Li, Xiaohui Guo, Jun Shen, Long Tan, Laixiang Lin, Yalan Wu, Wei Wang, Wenqiang Wang, Jianchao Bian, Wanqi Zhang
OBJECTIVE: To assess the validity of urinary iodine excretion (UIE) estimated by urinary iodine/creatinine ratio (UI/Cr) from spot urines in Chinese school-age children. DESIGN: A cross-sectional survey was performed in which twice-repeated collections of 24-h urine and spot urine samples were obtained within one month. MEASUREMENTS: Urinary iodine concentration (UIC), urinary creatinine concentration (UCr), urine volume (Uvol) of spot and 24-h urine samples were measured...
November 16, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27864985/telomeric-repeat-containing-rna-terra-related-to-polycystic-ovary-syndrome-pcos
#7
Caiqin Wang, Fengxian Shen, Yuning Zhu, Yuying Fang, Shiming Lu
CONTEXT: Telomeric repeat-containing RNA (TERRA) participates in the regulation of telomere length, and leukocyte telomere length (LTL) plays an important role in the pathophysiology of polycystic ovary syndrome (PCOS), but little is known about the role of TERRA in PCOS. OBJECTIVE: To evaluate the role of TERRA and peripheral blood leukocyte telomere length (LTL) in polycystic ovary syndrome (PCOS). DESIGN AND PARTICIPANTS: Forty women with PCOS and thirty-five heathy women without PCOS were recruited...
November 16, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27862146/maternal-25-hydroxyvitamin-d-is-inversely-correlated-with-fetal-serotonin
#8
Padma Murthi, Miranda Davies-Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M Wallace, Peter R Ebeling
OBJECTIVE: Maternal vitamin D deficiency during pregnancy has been linked to impaired neurocognitive development in childhood. The mechanism by which vitamin D affects childhood neurocognition is unclear but may be via interactions with serotonin, a neurotransmitter involved in fetal brain development. In this study we aimed to explore associations between maternal and fetal vitamin D concentrations, and fetal serotonin concentrations at term. STUDY DESIGN AND MEASUREMENTS: Serum 25-hydroxyitamin D (25(OH)D, nmol/L) and serotonin (5-HT, nmol/L) concentrations were measured in maternal and umbilical cord blood from mother-infant pairs (n=64)...
November 12, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27859437/characteristics-and-outcome-of-surgically-treated-pituitary-tumours-in-south-africa-a-single-centre-experience
#9
Khaled K Elmezughi, Fraser J Pirie, Ayesha A Motala
AIMS: To describe the clinical, biochemical, radiological and histological features and to determine the outcome of all patients with pituitary tumours treated surgically at Inkosi Albert Luthuli Central Hospital in Durban over a 5 year period. RESEARCH DESIGN: Retrospective chart review from 2008 to 2012. Clinical, biochemical and radiologic data were collected before and one year after surgery. Histopathology findings and peri-operative complications were recorded...
November 12, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27859511/one-hour-postload-plasma-glucose-concentration-in-people-with-normal-glucose-homeostasis-predicts-future-diabetes-mellitus-a-12-year-community-based-cohort-study
#10
Tae Jung Oh, Soo Lim, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Young Min Cho, Kyong Soo Park, HakChul Jang, Nam H Cho
OBJECTIVE: In Caucasians, plasma glucose concentration at 1 h during an oral glucose tolerance test (OGTT) may be a better predictor of future diabetes mellitus than the fasting or 2-h postload glucose concentration. We investigated whether the 1-h glucose concentration could be used to predict future diabetes mellitus in Asian ethnicity. MEASUREMENTS: A total of 5,703Koreans with normal glucose tolerance were enrolled from the Korean Genome and Epidemiology Study...
November 10, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27862139/differential-diagnosis-of-hyponatraemia-moving-forward
#11
Ewout J Hoorn
Hyponatraemia is a resident's nightmare. A water balance disorder disguised as decreased serum sodium concentration. A plethora of diagnostic algorithms that seem to have been developed with the sole purpose of getting you lost as quickly as possible. Nothing but untrustworthy parameters to guide you through this dark wood. And when you finally see light at the end of the tunnel, there is always some staff member, alias electrolyte aficionado, who enjoys public interrogation and makes you feel you're back to square one...
November 8, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27862131/scoring-system-for-the-diagnosis-of-bilateral-primary-aldosteronism-in-the-outpatient-setting-before-adrenal-venous-sampling
#12
Hiroki Kobayashi, Akira Haketa, Takahiro Ueno, Yukihiro Ikeda, Yoshinari Hatanaka, Sho Tanaka, Hiromasa Otsuka, Masanori Abe, Noboru Fukuda, Masayoshi Soma
OBJECTIVE: The only reliable method for subtyping primary aldosteronism (PA) is adrenal venous sampling (AVS), which is costly and time consuming. Considering the limited availability of AVS, it would be helpful to obtain information on the diagnosis of bilateral hyperaldosteronism (BHA) from routine tests. We aimed to establish new, simple criteria for outpatients to diagnose BHA from PA before AVS. DESIGN: We retrospectively analysed 82 patients who were diagnosed with PA and underwent AVS...
November 8, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27859451/altered-spontaneous-brain-activity-in-cushing-s-disease-a-resting-state-functional-mri-study
#13
Hong Jiang, Na-Ying He, Yu-Hao Sun, Fang-Fang Jian, Liu-Guan Bian, Jian-Kang Shen, Fu-Hua Yan, Si-Jian Pan, Qing-Fang Sun
CONTEXT AND OBJECTIVE: Cushing's disease (CD) provides a unique and naturalist model for studying the influence of hypercortisolism on the human brain and the reversibility of these effects after resolution of the condition. This cross-sectional study used resting state fMRI (rs-fMRI) to investigate the altered spontaneous brain activity in CD patients and the trends for potential reversibility after the resolution of the hypercortisolism. We also aim to determine the relationship of these changes with clinical characteristics and cortisol levels...
November 8, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27911001/diagnostic-accuracy-of-thyroid-imaging-reporting-and-data-system-in-the-prediction-of-malignancy-in-nodules-with-atypia-and-follicular-lesion-of-undetermined-significance-cytologies
#14
Husniye Baser, Bekir Cakir, Oya Topaloglu, Afra Alkan, Sefika Burcak Polat, Hayriye Tatli Dogan, Mustafa Omer Yazicioğlu, Cevdet Aydin, Reyhan Ersoy
OBJECTIVE: Thyroid Imaging Reporting and Data System (TIRADS) is a simple and reliable reporting system for the prediction of malignancy. We aimed to determine the role of TIRADS in the prediction of malignancy in subcategories of Bethesda Category III, atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS). DESIGN & PATIENTS: A total of 461 nodules with AUS cytology in 450 patients and 179 nodules with FLUS cytology in 168 patients were included...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27910111/cystatin-c-and-epicardial-adipose-tissue-as-noninvasive-predictors-of-cardiovascular-risk-in-acromegaly
#15
Anna Aulinas, Iris Crespo, David Viladés, Ruben Leta, Eulàlia Urgell, Betina Biagetti, Susan M Webb, Elena Valassi
BACKGROUND: Acromegaly (ACRO) is associated with elevated cardiovascular risk, although the prevalence of coronary artery disease (CAD) is unclear. Increased epicardial adipose tissue (EAT) and elevated cystatin-C (Cys-C) levels are cardiovascular risk factors, also related to the progression of CAD in several populations. AIMS: To measure the severity and extent of CAD in patients with ACRO and to determine whether either EAT or Cys-C reflect higher cardiovascular risk in patients with ACRO than in healthy controls...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27905124/assessment-of-early-atherosclerosis-and-left-ventricular-dysfunction-in-children-with-21-hydroxylase-deficiency
#16
Rahmi Özdemir, Hüseyin Anil Korkmaz, Mehmet Küçük, Cem Karadeniz, Timur Meşe, Behzat Özkan
AIM: We analysed 25 children with 21-hydroxylase deficiency who received glucocorticoid and/or mineralocorticoid treatment for at least 12 months to determine the effects of the disease and its treatment on vascular structures and ventricular function. METHODS: Twenty-five patients with 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) and 25 control subjects were enrolled into this observational, cross-sectional study. The patients were investigated in terms of fasting blood glucose and insulin; fasting serum lipid profile; serum 17-hydroxyprogesterone; dehydroepiandrosterone sulphate; androstenedione; and adrenocorticotropic hormone...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27809356/the-effect-of-growth-hormone-replacement-on-the-thyroid-axis-in-patients-with-hypopituitarism-in-vivo-and-ex-vivo-studies
#17
Nigel Glynn, Helena Kenny, Leah Quisenberry, David J Halsall, Paul Cook, Tommy Kyaw Tun, John H McDermott, Diarmuid Smith, Christopher J Thompson, Donal J O'Gorman, Anita Boelen, Joaquin Lado-Abeal, Amar Agha
OBJECTIVE: Alterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (GH) replacement. The aim was examine the relationship between changes in serum concentration of thyroid hormones and deiodinase activity in subcutaneous adipose tissue, before and after GH replacement. DESIGN: A prospective, observational study of patients receiving GH replacement as part of routine clinical care. PATIENTS: Twenty adult hypopituitary men...
November 3, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27809335/higher-thyrotropin-concentration-is-associated-with-increased-incidence-of-colorectal-cancer-in-older-men
#18
Yi X Chan, Helman Alfonso, S A Paul Chubb, P Gerry Fegan, Graeme J Hankey, Jonathan Golledge, Leon Flicker, Bu B Yeap
CONTEXT: Thyroid hormones regulate cellular survival and metabolism; however their association with cancer incidence and death has not been well explored. OBJECTIVES: Our aim was to examine the relationship between thyrotropin (TSH) and free thyroxine (FT4) with cancer incidence (all cancers, prostate, colorectal and lung cancer). Associations with cancer-related deaths were also explored. DESIGN AND SETTING: A prospective cohort study involving community-dwelling men aged 70-89 years...
November 3, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27805280/iodine-deficiency-amongst-pregnant-women-in-south-west-england
#19
Bridget A Knight, Beverley M Shields, Xuemei He, Elizabeth N Pearce, Lewis E Braverman, Rachel Sturley, Bijay Vaidya
INTRODUCTION: Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West England. METHODS: Urine samples were obtained from 308 women participating in a study of breech presentation in late pregnancy. They had no known thyroid disease and a singleton pregnancy at 36-38 weeks' gestation...
November 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27805276/anti-m%C3%A3-llerian-hormone-reflects-the-severity-of-polycystic-ovary-syndrome
#20
S L Jacob, H P Field, N Calder, H M Picton, A H Balen, J H Barth
OBJECTIVE: To examine the relationship between anti-Müllerian hormone (AMH) and the severity of the phenotype of patients with polycystic ovary syndrome (PCOS) and whether AMH can act as a diagnostic marker for PCOS? DESIGN: A prospective diagnostic utility study of AMH as a marker of PCOS. PATIENTS: A consecutive series of women presenting to a tertiary infertility clinic (n = 164) plus a second series of women prepared for assisted conception treatments (n = 89) recruited between June 2012 and May 2013...
November 2, 2016: Clinical Endocrinology
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