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Clinical Endocrinology

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https://www.readbyqxmd.com/read/28316090/impaired-quality-of-life-in-patients-with-treated-acromegaly-despite-long-term-biochemically-stable-disease-results-from-a-5-year-prospective-study
#1
Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray
OBJECTIVE: Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN: The study consists of a cross-sectional arm comparing QoL between patients with treated and controlled acromegaly and healthy controls; and a longitudinal arm assessing QoL changes in patients with biochemically stable disease during 5...
March 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28316075/a-case-control-study-of-the-association-between-ulcerative-colitis-and-hyperthyroidism-in-an-asian-population
#2
Ming-Chieh Tsai, Herng-Ching Lin, Cha-Ze Lee
OBJECTIVE: Ulcerative colitis (UC) is a chronic relapsing inflammatory disease with significant clinical diversity. However, the etiology, pathogenesis, and optimal treatment of UC remain unclear. The purpose of this case-control study was to investigate the association between previously diagnosed hyperthyroidism and UC using a large population-based dataset in Taiwan. METHODS: The data for this population-based case-control study were retrieved from the Taiwan Longitudinal Health Insurance Database 2005...
March 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28316072/the-effects-of-dash-diet-on-weight-loss-anti-m%C3%A3-llerian-hormone-and-metabolic-profiles-in-women-with-polycystic-ovary-syndrome-a-randomized-clinical-trial
#3
Fatemeh Foroozanfard, Hamideh Rafiei, Mansooreh Samimi, Hamid Reza Gilasi, Roohangiz Gorjizadeh, Zahra Heidar, Zatollah Asemi
OBJECTIVE: This study was designed to evaluate the effects of the Dietary Approaches to Stop Hypertension (DASH diet) on weight loss, anti-Müllerian hormone (AMH) and metabolic profiles in women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS: A randomized controlled clinical trial was conducted among 60 overweight or obese patients with PCOS. Patients were randomly assigned to receive either low-calorie DASH (N=30) or control diet (N=30) for 12 weeks...
March 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28306165/is-gh-dosing-optimal-in-female-patients-with-adult-onset-gh-deficiency-an-analysis-from-the-nordinet-%C3%A2-international-outcome-study
#4
Charlotte Höybye, Matthias M Weber, Effie Pournara, Birgitte Tønnes Pedersen, Beverly M K Biller
OBJECTIVE: To evaluate gender differences in GH dosing, IGF-I and cardiovascular risk markers in adults with GH deficiency (GHD). DESIGN: NordiNet(®) International Outcome Study (NCT00960128), a non-interventional, multicentre study, evaluates the long-term effectiveness and safety of Norditropin(®) (Novo Nordisk A/S) in the real-life clinical setting. PATIENTS: Non-diabetic patients (n=252; 41.7% female) with adult-onset GHD (age ≥20 years at GH start), ≥4 years' GH therapy, and glycosylated haemoglobin (HbA1c ) data at baseline and 4 years...
March 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28295470/preconception-tsh-levels-and-pregnancy-outcomes-a-population-based-cohort-study-in-184-611-women
#5
Shi Chen, Xiang Zhou, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Man Zhang, Yu Jiang, Chengsheng Yan, Jianqiang Li, Qing Wang, Shikun Zhang, Hui Pan
BACKGROUND: Whether subclinical hypothyroidism adversely impacts pregnancy outcomes is inconclusive, and limited data are available on the optimal TSH range in women planning pregnancy. OBJECTIVE: To investigate the association between maternal preconception TSH levels and pregnancy outcomes. DESIGN: Population-based cohort study. METHODS: From 2010 to 2012, the free National Pre-pregnancy Checkups Project recruited 248,501 pairs of volunteer couples across China, of which 184,611women, who subsequently became pregnant, were studied...
March 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28295509/measuring-tsh-receptor-antibody-trab-to-influence-treatment-choices-in-graves-disease
#6
Asha Hesarghatta Shyamasunder, Prakash Abraham
TSH receptor antibody (TRAb) plays a key role in the pathogenesis of Graves' disease (GD) and its levels correlate with the clinical course. The 2(nd) and 3(rd) generation TRAb assays have >95% sensitivity and specificity for the diagnosis of GD, and have improved the utility of TRAb to predict relapse. TRAb levels decline with antithyroid drug (ATD) therapy and after thyroidectomy. Its level increases for a year following radioactive iodine (RAI) therapy, with a gradual fall thereafter. TRAb level >12 IU/L at diagnosis of GD is associated with 60% risk of relapse at 2 years and 84% at 4 years...
March 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28295469/assessing-new-peptides-that-may-be-involved-in-the-physiological-regulation-of-the-gonadal-axis-in-humans-gonadotropin-inhibitory-hormone
#7
Peter Y Liu
The hypothalamo-pituitary-testicular (HPT) and hypothalamo-pituitary-ovarian (HPO) axes are integrated networks that regulate androgenization or estrogenization (including embryonic, infantile, pubertal and adult sexual maturation), male or female sexual behavior, and spermatogenesis or ovulation, respectively. Dysregulation of the HPT axis, for example, results in pubertal delay, eunuchism, impaired spermatogenesis, and reduced systemic androgen exposure; and may also contribute to some of the features of male aging, impair recovery from protracted critical illness, and induce visceral adiposity, sarcopenia, osteopenia, and insulin resistance...
March 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28295444/the-polymorphic-cag-repeat-in-exon1-of-androgen-receptor-is-associated-with-level-of-hdl-cholesterol-and-hypertension-in-chinese-middle-aged-to-elderly-men
#8
Deyu Yang, Jinhai Tian, Xu Zhang, Jingjing Yu, Shuya Li, Zhizhong Wang, Yuying Ma, Lan Liu, Qi Huang, Rong Ma, Jia Wang, Xin Li, Min Jiang
OBJECTIVE: The length of the CAG repeats in exon 1 of the androgen receptor (AR) gene has been shown to be inversely correlated with AR transcriptional activity. This study aimed to investigate the correlations between the length of CAG repeat in AR and serum lipids and hypertension in Chinese men. DESIGN AND PATIENTS: The relationship between length of the CAG repeat in exon 1 of AR with prevalence ofhypertension and the levels of serum lipids among Chinese men(aged ≥ 40 years)...
March 10, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28273382/hashimoto-s-thyroiditis-relative-recurrence-risk-ratio-and-implications-for-screening-of-first-degree-relatives
#9
Nikita Bothra, Nalini Shah, Manjunath Goroshi, Swati Jadhav, Sheetal Padalkar, Hemangini Thakkar, Gurudayal Singh Toteja, Vyankatesh Shivane, Anurag Lila, Tushar Bandgar
CONTEXT: The relative recurrence risk ratio (λR ) for Hashimoto's thyroiditis (HT) has not been widely studied. The age at which thyroid function evaluation should be initiated for relatives of HT patients remains unclear. OBJECTIVE: To study λR and age-related prevalence of HT in first degree relatives of HT patients. METHODS: First degree relatives (n=861) of 264 HT patients were evaluated for goitre, thyroid function tests, thyroid antibodies (TAb) and urinary iodide concentration (UIC)...
March 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28273370/features-of-papillary-thyroid-microcarcinoma-associated-with-lateral-cervical-lymph-node-metastasis
#10
Min Ji Jeon, Mi Sun Chung, Hyemi Kwon, Mijin Kim, Suyeon Park, Jung Hwan Baek, Dong Eun Song, Tae-Yon Sung, Suck Joon Hong, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Jeong Hyun Lee, Won Gu Kim
OBJECTIVES: Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the preoperative features of PTMC associated with LCLN metastasis. DESIGN AND PATIENTS: This retrospective cohort study with a nested, matched case-control design included 199 PTMC patients with LCLN metastasis at initial surgery (N1b group) and 196 PTMC patients without any LN metastasis or persistent disease (N0 NED group) as controls; primary tumour sizes were matched...
March 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28273369/is-estrogen-exposure-a-protective-factor-for-pancreatic-neuroendocrine-tumors-in-female-multiple-endocrine-neoplasia-syndrome-type-1-patients
#11
Wei Qiu, Ioannis Christakis, Ashley A Stewart, Danica M Vodopivec, Angelica Silva-Figueroa, Huiqin Chen, Terri L Woodard, Daniel M Halperin, Jeffrey E Lee, James C Yao, Nancy D Perrier
OBJECTIVE: Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in multiple endocrine neoplasia type 1 (MEN1) patients. Women have been shown to have improved survival, which may suggest a possible protective effect of female sex hormones. The aim of this study was to evaluate the relationship between estrogen exposure and PNET tumorigenesis, tumor growth, and survival in female MEN1 patients with these tumors. DESIGN: We performed a retrospective chart review of the existing MEN1 database in our institution...
March 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28261833/diagnostic-utility-of-testosterone-priming-prior-to-dynamic-tests-to-differentiate-constitutional-delay-in-puberty-from-isolated-hypogonadotropic-hypogonadism
#12
Suja P Sukumar, Anil Bhansali, Naresh Sachdeva, Chirag Kamal Ahuja, Ujjwal Gorsi, Kush Dev Singh Jarial, Rama Walia
CONTEXT: Differentiation between constitutional delay in puberty (CDP) and isolated hypogonadotropic hypogonadism (IHH) during adolescence is a great clinical challenge and the available diagnostic tests are of limited value. OBJECTIVE: To study the effect of withdrawal of short term, low dose testosterone therapy (testosterone priming) on the discriminatory power of dynamic tests for hypothalamo-pituitary-testicular axis to differentiate CDP from IHH. DESIGN: A prospective study (n=30) consisting of 20 boys with delayed puberty (Group A) and 10 patients with IHH (Group B)...
March 5, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28256078/ultrasonography-and-cytology-as-predictors-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-importance-of-the-differential-diagnosis-with-the-invasive-encapsulated-follicular-variant-of-papillary-thyroid-cancer
#13
Pedro Weslley Rosario
The noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) has an excellent prognosis even if treated only by lobectomy.(1-3) Recently, it was proposed that this tumor should no longer be considered "cancer" and be given the denomination "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP).(2) There is great interest in knowing the preoperative characteristics of NIFTP since, in view of a high probability of this diagnosis (higher than that of malignancy), less extensive surgery would be more indicated...
March 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28251701/molecular-effect-of-fenofibrate-on-pbmc-gene-transcription-related-to-lipid-metabolism-in-metabolic-syndrome-patients
#14
I Moreno-Indias, F J Tinahones, M Clemente-Postigo, D Castellano-Castillo, J C Fernández-García, M Macias-Gonzalez, M I Queipo-Ortuño, F Cardona
BACKGROUND: Both fasting and postprandial hypertriglyceridaemia are considered independent risk factors for atherosclerosis. Treatment of hypertriglyceridaemia is based on fibrates, which activate the peroxisome proliferator-activated receptor alpha (PPARα). However, the metabolic pathways that activate or inhibit fibrates, and how the postprandial triglyceride levels are modified, have not yet been fully described. Accordingly, the aim of this study was to determine the feasibility of peripheral blood mononuclear cells (PBMC) to study the effects of fenofibrate in patients with the metabolic syndrome...
March 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28251655/the-vitamin-d-metabolite-ratio-vmr-as-a-predictor-of-functional-biomarkers-of-bone-health
#15
John Aloia, Melissa Fazzari, Albert Shieh, Ruban Dhaliwal, Mageda Mikhail, Andrew N Hoofnagle, Lou Ragolia
CONTEXT: The Vitamin D Metabolite Ratio (VMR) (Serum 24,25(OH)2 D3 /25(OH)D3 ) has been proposed as a biomarker of vitamin D sufficiency to replace serum 25(OH)D. OBJECTIVE: To examine the relationships of 24,25(OH)2 D3 and VMR to functional biomarkers of bone health following vitamin D supplementation. SETTING: An ambulatory research center. DESIGN: Serum from a previous research study of dose-response of PTH, calcium absorption and bone turnover to vitamin D supplementation was analyzed for vitamin D metabolites (25(OH)D, 24,25(OH)2 D3 )...
March 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28247534/heterogeneity-in-phenotype-of-hyperinsulinism-caused-by-activating-glucokinase-mutations-a-novel-mutation-and-its-functional-characterization
#16
Rosa Martínez, Ángel Gutierrez-Nogués, Concepción Fernández-Ramos, Teresa Velayos, Amaia Vela, María-Ángeles Navas, Luis Castaño
BACKGROUND: Mutations in the GCK gene lead to different forms of GCK-disease, activating mutations cause hyperinsulinemic hypoglycemia while inactivating mutations cause monogenic diabetes. Hyperinsulinism (HI) is a heterogeneous condition with a significant genetic component. The major causes are channelopathies, the other forms are rare and being caused by mutations in genes such as GCK. OBJECTIVE: To describe the clinical and genetic presentation of four families with activating GCK mutations, and to explore the pathogenicity of the novel mutation identified through functional studies...
March 1, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28222214/segregation-and-expression-analyses-of-habp2-insights-from-a-large-series-of-familial-non-medullary-thyroid-cancers-and-literature-review
#17
Carla Colombo, Marina Muzza, Maria Carla Proverbio, Giulia Ercoli, Michela Perrino, Valentina Cirello, Leonardo Vicentini, Stefano Ferrero, Laura Fugazzola
INTRODUCTION: Recently, the G534E variant of the HABP2 gene was reported as the underlying genetic defect in a large kindred with non-syndromic familial non medullary thyroid cancer (FNMTC). Nevertheless, this postulated role was not confirmed in additional cohorts. Contrasting data are also available on HABP2 expression in the thyroid. OBJECTIVES: To investigate HABP2 as a potential susceptibility gene in a large series of 27 unrelated families with FNMTC and to test its expression in thyroid tumor and matched normal tissues...
February 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28214374/a-systematic-review-of-known-interventions-for-the-treatment-of-chronic-non-hypovolaemic-hypotonic-hyponatraemia-and-a-meta-analysis-of-the-vaptans
#18
REVIEW
Sunil Bhandari, Alessandro Peri, Iain Cranston, Rachael McCool, Alison Shaw, Julie Glanville, Larisa Petrakova, Karl O'Reilly
International and national guidelines on the treatment of chronic non-hypovolaemic hypotonic hyponatraemia differ; therefore we have undertaken this systematic review and meta-analysis to investigate the efficacy and safety of interventions for the treatment of chronic non-hypovolaemic hypotonic hyponatraemia. Following registration of the review protocol with PROSPERO, systematic literature searches were conducted to identify randomised and quasi-randomised controlled trials assessing any degree of fluid restriction or any drug treatment with the aim of increasing serum sodium concentration in patients with chronic non-hypovolaemic hypotonic hyponatraemia...
February 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28199740/incidence-of-abnormal-liver-biochemical-tests-in-hyperthyroidism
#19
Tiffany Y Lin, Anshula O Shekar, Ning Li, Michael W Yeh, Sammy Saab, Mark Wilson, Angela M Leung
OBJECTIVE: Abnormal serum liver function tests are common in patients with untreated thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen their severity. There is a wide range of the incidence of these abnormalities in the published literature. The aim of this study was to assess the risks factors and threshold of thyrotoxicosis severity for developing an abnormal liver biochemical test upon the diagnosis of new thyrotoxicosis. DESIGN: Single-institution retrospective cohort study...
February 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28199739/obesity-in-children-with-congenital-adrenal-hyperplasia-in-the-minnesota-cohort-importance-of-adjusting-body-mass-index-for-height-age
#20
Kyriakie Sarafoglou, Gregory P Forlenza, O Yaw Addo, Jennifer Kyllo, Aida Lteif, P C Hindmarsh, Anna Petryk, Maria Teresa Gonzalez-Bolanos, Bradley S Miller, William Thomas
OBJECTIVES: To evaluate obesity and overweight in children with congenital adrenal hyperplasia (CAH), and associations with glucocorticoids, fludrocortisone and disease control. Adjusting body mass index for-height-age (BMIHA ) percentile is proposed to correct misclassification of obese/overweight status in CAH children with advanced bone age and tall-for-age stature. DESIGN: Longitudinal. PATIENTS: 194 children with CAH seen from 1970-2013: 124 salt-wasting (SW); 70 simple-virilizing (SV); 102 females...
February 15, 2017: Clinical Endocrinology
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