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Clinical Endocrinology

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https://www.readbyqxmd.com/read/28906021/primary-hyperparathyroidism-dynamic-postoperative-metabolic-changes
#1
Reto Martin Kaderli, Philipp Riss, Angelika Geroldinger, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated. DESIGN: Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intraoperatively, at post-operative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6...
September 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28906015/influence-of-coexistent-hashimoto-s-thyroiditis-on-the-extent-of-cervical-lymph-node-dissection-and-prognosis-in-papillary-thyroid-carcinoma
#2
Eyun Song, Min Ji Jeon, Suyeon Park, Mijin Kim, Hye-Seon Oh, Dong Eun Song, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
OBJECTIVE: Previous studies did not focus on the differences in the extent of cervical lymph node (LN) dissection according to coexistent Hashimoto's thyroiditis (HT) in patients with papillary thyroid carcinoma (PTC) and its clinical impact. We aimed to determine whether extensive cervical LN dissection is responsible for favorable clinical outcomes in PTC patients with HT and whether coexistence of HT itself has an independent protective effect regardless of LN status. DESIGN: Retrospective cohort study PATIENTS: 1,369 patients with PTC who underwent total thyroidectomy with central compartment neck dissection...
September 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28898488/prevention-of-total-thyroidectomy-in-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-based-on-combined-interpretation-of-ultrasonographic-and-cytopathologic-results
#3
Sung-Hye You, Kyu Eun Lee, Roh-Eul Yoo, Hye Jeong Choi, Kyeong Cheon Jung, Jae-Kyung Won, Koung Mi Kang, Tae Jin Yoon, Seung Hong Choi, Chul-Ho Sohn, Ji-Hoon Kim
OBJECTIVE: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP CONTEXT: Recently, it has been proposed that that non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumors, rather than cancer. PATIENTS: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20.4±11.0 mm, range: 10...
September 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28898436/letter-to-liu-et%C3%A2-al-2017-article
#4
Richard S Legro
I was intrigued to see the recent trial of Liu et al(1) reporting the benefits of exenatide over metformin in terms of weight loss and pregnancy rate in women with polycystic ovary syndrome. I am writing to clarify the discrepancies between the trial as registered and the trial as reported in the manuscript. According to the trial registration on the Chinese Clinical Trial Registration Site (ChiCTR-IIR-16008084) the trial was a three armed trial for exenatide, metformin, or spironolactone. This article is protected by copyright...
September 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28862752/thyroid-stimulating-hormone-and-risk-of-sudden-cardiac-death-total-mortality-and-cardiovascular-morbidity
#5
Ville L Langén, Teemu J Niiranen, Pauli Puukka, Arttu O Lehtonen, Jussi A Hernesniemi, Jouko Sundvall, Veikko Salomaa, Antti M Jula
BACKGROUND: Previous data on the association of thyroid function with total mortality, cardiovascular disease (CVD) outcomes and sudden cardiac death (SCD) are conflicting or limited. We investigated associations of thyroid-stimulating hormone (TSH) with these outcomes in a nationwide population-based prospective cohort study. METHODS: We examined 5211 participants representative of the Finnish population aged ≥30 years in 2000-2001 and followed them for a median of 13...
September 1, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28850717/genetics-of-cushing-s-disease
#6
Adriana Albani, Marily Theodoropoulou, Martin Reincke
Cushing's disease (CD) is a rare disabling condition caused by ACTH-secreting adenomas of the pituitary. The majority of corticotropic adenomas are monoclonal and occur sporadically. Only rarely does CD arise in the context of genetic familial syndromes. Targeted sequencing of oncogenes and tumour-suppressor genes commonly mutated in other tumours did not identify recurrent mutations. In contrast, next generation sequencing allowed us recently to clarify the genetic basis of CD: We identified somatic driver mutations in the ubiquitin-specific protease 8 (USP8) gene in a significant portion of corticotropinomas...
August 29, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28850708/the-association-between-subclinical-thyroid-dysfunction-and-dementia-the-health-aging-and-body-composition-health-abc-study
#7
Carole E Aubert, Douglas C Bauer, Bruno R da Costa, Martin Feller, Carole Rieben, Eleanor M Simonsick, Kristine Yaffe, Nicolas Rodondi
OBJECTIVE: Data on the association between subclinical thyroid dysfunction and dementia are limited and conflicting. We aimed to determine whether subclinical thyroid dysfunction was associated with dementia and cognitive decline. DESIGN: Population-based prospective cohort study. PATIENTS: Adults aged 70-79 years with measured thyroid function, but no dementia at baseline, and Modified Mini-Mental State (3MS) at baseline and follow-up. MEASUREMENTS: Primary outcome was incident adjudicated dementia, based on 3MS, hospital records, and dementia drugs...
August 29, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28845895/bone-markers-in-polycystic-ovary-syndrome-a-multi-centre-study
#8
Shilpa Lingaiah, Laure Morin-Papunen, Terhi Piltonen, Johanna Puurunen, Inger Sundström-Poromaa, Elisabet Stener-Victorin, Risto Bloigu, Juha Risteli, Juha S Tapanainen
OBJECTIVE: Hyperandrogenism, hyperinsulinemia and obesity, known characteristics of polycystic ovary syndrome (PCOS), may influence bone mineral density and biochemical markers of bone turnover (BTMs) can provide a non-invasive assessment of bone turnover. To this end, the serum concentrations of BTMs and 25-hydroxyvitamin D (25OHD) were analysed in women with PCOS and their possible associations with metabolic parameters of PCOS were determined. SUBJECTS AND METHODS: Bone formation markers procollagen type I amino-terminal propeptide (PINP) and osteocalcin (OC), and bone resorption marker carboxy-terminal cross-linking telopeptide of type I collagen (CTX), along with 25OHD, were measured in 298 women with PCOS and 194 healthy controls...
August 28, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28834559/improving-the-pre-hospital-safety-of-steroid-dependent-patients-in-northern-england-a-hospital-initiated-ambulance-service-registration-pathway
#9
Anna L Mitchell, Kerri Devine, Vikram Lal, Paul Galloway, Matthew House, Katherine White, Julie Watson, Steve Parry, Margaret Miller, Margaret Morris, R Andy James, Petros Perros, Simon Hs Pearce, Richard Quinton
Acute adrenal crisis is a life-threatening medical emergency requiring immediate recognition and treatment. Among individuals with primary adrenal insufficiency it has a frequency of 6-8 per 100 patient-years(1) . Unfortunately, delays in diagnosis and management of acute adrenal crisis are commonplace - even in patients with documented steroid-dependency - constituting an avoidable source of patient harm. This article is protected by copyright. All rights reserved.
August 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28834553/efficacy-of-exenatide-on-weight-loss-metabolic-parameters-and-pregnancy-in-overweight-obese-polycystic-ovary-syndrome
#10
Xin Liu, Ying Zhang, Si-Yuan Zheng, Rong Lin, Yi-Juan Xie, Hui Chen, Yong-Xiong Zheng, En Liu, Lin Chen, Jia-He Yan, Wei Xu, Ting-Ting Mai, Yi Gong
CONTEXT: Weight loss remains one of the most important arms in obese patients with polycystic ovary syndrome (PCOS). Further studies are needed to identify the best treatment. OBJECTIVE: To evaluate the effects of exenatide (EXE) on reproductive and metabolic function in overweight/obese (OW/OB) PCOS. DESIGN: This is a 24-week open-label prospective, randomized, clinical study. PATIENTS AND MEASUREMENTS: This study randomized 176 OW/OB women diagnosed with PCOS to receive either EXE 10 μg BID (n = 88) or metformin (MET) 1000 mg BID (n = 88) for the first 12 weeks...
August 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28833384/primary-hyperparathyroidism-in-chinese-children-and-adolescents-a-single-center-experience-at-peking-union-medical-college-hospital
#11
Wenbo Wang, Jing Kong, Min Nie, Yan Jiang, Mei Li, Weibo Xia, Xunwu Meng, Xiaoping Xing, Ou Wang
OBJECTIVE: Primary hyperparathyroidism (PHPT) in children is thought to be extremely rare. Our study aimed to summarize the clinical characteristics and the molecular genetics in patients with pediatric PHPT in China. DESIGN: Retrospective observational study. METHODS: A total of 59 pediatric PHPT patients (onset age <18 years) admitted to Peking Union Medical College Hospital from 1975 to 2015 were retrospectively identified. A group of 118 adult PHPT patients who presented during the same period were selected for comparing clinical characteristics between the two groups...
August 22, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28833398/assessment-of-time-to-glucose-peak-during-an-oral-glucose-tolerance-test
#12
LETTER
Adam Hulman, Daniel R Witte, Dorte Vistisen, Kristine Faerch
No abstract text is available yet for this article.
August 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28833369/clinical-and-genetic-features-of-64-young-male-paediatric-patients-with-congenital-hypogonadotropic-hypogonadism-chh
#13
Yi Wang, Chunxiu Gong, Miao Qin, Ying Liu, Yuanyuan Tian
CONTEXT: The diagnosis of congenital hypogonadotropic hypogonadism (CHH) in prepuberty has always been challenging. Here, we aimed at studying the clinical and genetic features of paediatric CHH, especially the phenotype of hypospadias and dual defects (patients showing hypothalamic and/or pituitary defects and testicular hypoplasia), so as to have a better understanding of CHH. DESIGN: The clinical and genetic features of CHH patients were analysed and the relationships between hypospadias, dual defects and genetics investigated...
August 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28833367/iron-metabolism-in-patients-with-graves-hyperthyroidism
#14
Stefan Fischli, Viktor von Wyl, Michael Trummler, Daniel Konrad, Stephan Wueest, Axel Ruefer, Kerstin Heering, Regina Streuli, Christian Steuer, Luca Bernasconi, Mike Recher, Christoph Henzen
OBJECTIVES: Graves' hyperthyroidism (GH) interferes with iron metabolism and elevates ferritin. The precise mechanisms remain unclear. The influence of thyroid hormones on the synthesis/regulation of hepcidin, an important regulator of iron metabolism, remains uncharacterized. DESIGN: Prospective observational study. PATIENTS: We included patients (n=31) with new-onset and untreated GH. MEASUREMENTS: Laboratory parameters indicative of iron metabolism (ferritin, transferrin, hepcidin), inflammatory markers/cytokines and smoking status were assessed at the diagnosis of GH (T0) and at euthyroidism (T1) in the same patients using multivariable analyses...
August 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28833355/serum-chemerin-levels-are-inversely-associated-with-renal-function-in-a-general-population
#15
Stephanie Zylla, Rainer Rettig, Henry Völzke, Karlhans Endlich, Matthias Nauck, Nele Friedrich
OBJECTIVE: Chemerin has been found to be highly expressed in the kidneys of rodents and has been suggested to affect metabolic syndrome (MetS)-related phenotypes which are in turn related to kidney damage. Only few clinical studies have addressed the relation between circulating chemerin and renal function in humans and no population-based analyses have yet been performed. The potential influence of MetS-related phenotypes on the assumed association has been largely neglected. We aimed to investigate the association of serum chemerin with renal function in a general population with special regard to possible interactions between chemerin and metabolic phenotypes...
August 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28815667/diagnostic-performance-of-unenhanced-computed-tomography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-indeterminate-adrenal-tumours
#16
Danae A Delivanis, Irina Bancos, Thomas D Atwell, Grant D Schmit, Patrick W Eiken, Neena Natt, Dana Erickson, Spyridoula Maraka, William F Young, Mark A Nathan
OBJECTIVE: Evidence on the diagnostic performance of adrenal imaging is limited. We aimed to assess the diagnostic performance of unenhanced computed tomography (CT) and (18) F-fluorodeoxyglucose ((18) FDG) positron emission tomography (PET)/CT imaging in a high-risk population for adrenal malignancy using an optimal reference standard. DESIGN: Retrospective cohort study. METHODS: Imaging studies of patients with adrenal nodules who underwent adrenal biopsy and/or adrenalectomy between 1994 and 2014 were reviewed and compared to the reference standard of histology...
August 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28815660/absorption-and-tolerability-of-taste-masked-hydrocortisone-granules-in-neonates-infants-and-children-under-6%C3%A2-years-of-age-with-adrenal-insufficiency
#17
Uta Neumann, Martin J Whitaker, Susanna Wiegand, Heiko Krude, John Porter, Madhu Davies, Dena Digweed, Bernard Voet, Richard J Ross, Oliver Blankenstein
OBJECTIVES: There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort(®) , an immediate-release, granule formulation of hydrocortisone with taste masking. STUDY DESIGN: Single site with satellites attended by a "flying" doctor from investigator site. Open-label, single-dose study in three consecutive child cohorts (n = 24) with AI; Cohort 1, children aged 2 to <6 years (n = 12); Cohort 2, infants aged 28 days to <2 years (n = 6); Cohort 3, neonates aged 1 to <28 days (n = 6)...
August 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28802067/crh-stimulation-tests-for-the-infants-with-relative-adrenal-insufficiency
#18
Kougoro Iwanaga, Akane Yamamoto, Takashi Matsukura, Fusako Niwa, Masahiko Kawai
BACKGROUND: Very low birth weight (VLBW) infants are considered to be vulnerable to relative adrenal insufficiency (RAI); however, diagnosis is difficult in some clinical settings. Considering this background, it is necessary to establish a diagnosis of RAI in preterm infants. OBJECTIVE: In this study, we attempted to clarify the difference in response to CRH stimulation tests for preterm infants with or without RAI. METHODS: Between June 2009 and December 2015, we performed CRH stimulation tests for preterm infants born at a gestational age of <30 weeks at around two weeks of age...
August 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28802064/neurokinin-3-receptor-antagonism-decreases-gonadotropin-and-testosterone-secretion-in-healthy-men
#19
Karolina Skorupskaite, Jyothis T George, Johannes D Veldhuis, Robert P Millar, Richard A Anderson
OBJECTIVE: Patients with mutations of neurokinin B (NKB) and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or its functional hierarchy with kisspeptin. DESIGN: An open label study wherein men (n = 6) were administered the NK3R antagonist MLE4901 40 mg orally twice a day for 7 days. Kisspeptin-10 (0.3 μg/kg iv bolus) was given before and on day 7 of NK3R antagonist treatment...
August 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28799235/dipeptidyl-peptidase-4-serum-activity-and-concentration-are-increased-in-women-with-polycystic-ovary-syndrome
#20
Sindy Blauschmidt, Thomas Greither, Katharina Lampe, Solveig Köller, Petra Kaltwaßer, Hermann M Behre
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a complex disease, the aetiology of which is not well understood. Alterations in potential candidate genes involved in the biosynthesis and metabolism of androgens, folliculogenesis and insulin and glucose metabolism have been suggested as possible aetiologies. Dipeptidyl peptidase-4 (DPP4) plays a key role in glucose homoeostasis and, thus, in the regulation of insulin secretion. The aim of our study was to analyse the DPP4 activity and concentrations in the serum of PCOS and non-PCOS patients and, additionally, study the activation of the DPP4 promoter by androgens in vitro...
August 11, 2017: Clinical Endocrinology
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