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Clinical Endocrinology

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https://www.readbyqxmd.com/read/29149458/hormone-therapy-and-patients-satisfaction-with-treatment-in-a-large-cohort-of-diverse-disorders-of-sex-development-dsd
#1
Anna Nordenström, Robert Röhle, Ute Thyen, Claire Bouvattier, Jolanta Slowikowska-Hilczer, Nicole Reisch, Hedi Claahsen van der Grinten, Aude Brac de la Perriere, Peggy T Cohen-Kettenis, Birgit Köhler
OBJECTIVES: To describe and investigate the hormone treatments in individuals with different forms of disorders of sex development (DSD), and the patients own views on their treatment. DESIGN: Multicentre cross-sectional clinical evaluation, dsd-LIFE in six European countries from 02/2014 to 09/2015. PARTICIPANTS: 1040 adolescents and adults (≥16 years) with different DSD conditions. MAIN OUTCOMES MEASURES: Hormone replacement, information received and patient satisfaction...
November 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29144548/anti-m%C3%A3-llerian-hormone-measurement-for-the-diagnosis-of-polycystic-ovary-syndrome
#2
Thozhukat Sathyapalan, Ahmed Al-Qaissi, Eric S Kilpatrick, Soha R Dargham, Stephen L Atkin
OBJECTIVE: Anti-Müllerian hormone (AMH) is derived from the small antral follicles and an elevated level has been suggested to add value to the Rotterdam criteria for the diagnosis of PCOS in cases of diagnostic uncertainty. Therefore, the role of AMH in the classical phenotype of PCOS was defined within a Caucasian population. DESIGN: This was a cross sectional study. PATIENTS: 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria...
November 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29136292/clinical-and-genetic-characteristics-of-pseudohypoparathyroidism-in-the-chinese-population
#3
Xueying Chu, Yan Zhu, Ou Wang, Min Nie, Tingting Quan, Yu Xue, Wenbo Wang, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing
BACKGROUND: Pseudohypoparathyroidism (PHP) is caused by mutations and epimutations in the GNAS locus, and characterized by the possibility of resistance to multiple hormones and Albright's hereditary osteodystrophy. PHP can be classified into the forms 1A/C, sporadic 1B, and familial 1B. OBJECTIVES: To obtain an overall view of the clinical and genetic characteristics of the Chinese PHP patient population. METHODS: From 2000 to 2016, 120 patients were recruited and studied using Sanger sequencing, methylation-specific multiple ligation-dependent probe amplification (MS-MLPA), and combined bisulfiterestriction analysis (COBRA)...
November 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29130501/tert-promoter-hypermethylation-is-associated-with-metastatic-disease-in-abdominal-paraganglioma
#4
Fredrika Svahn, C Christofer Juhlin, Johan O Paulsson, Omid Fotouhi, Jan Zedenius, Catharina Larsson, Adam Stenman
Telomere maintenance, a hallmark of cancer for cell immortalization, is commonly achieved by telomerase activation through induction of the telomerase reverse transcriptase (TERT) gene. Pheochromocytomas (PCC) and abdominal paragangliomas (PGL) (together PPGL) are endocrine tumours for which TERT promoter mutations and telomerase activation have been previously reported [1]. Only 10-15% of PPGL metastasize, however in the absence of metastases, the identification of malignant disease is a diagnostic dilemma...
November 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29115003/impact-of-hypercortisolism-on-skeletal-muscle-mass-and-adipose-tissue-mass-in-patients-with-adrenal-adenomas
#5
Danae A Delivanis, Nicole M Iñiguez-Ariza, Muhammad H Zeb, Michael R Moynagh, Naoki Takahashi, Travis J McKenzie, Melinda A Thomas, Charalambos Gogos, William F Young, Irina Bancos, Venetsana Kyriazopoulou
CONTEXT: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. OBJECTIVE: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. DESIGN: Retrospective cohort study. PATIENTS: Twenty-five patients with overt Cushing syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE), and 32 patients with a non-functioning adrenal tumor (NFAT) were included...
November 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29112786/circulating-b-type-natriuretic-peptide-in-women-with-and-without-recent-gestational-diabetes-the-impact-of-current-glucose-intolerance
#6
Leanne R De Souza, Chang Ye, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
CONTEXT: Circulating B-type natriuretic peptide, as measured by the N-terminal fragment of its prohormone (NT-proBNP), is inversely associated with incident type 2 diabetes (T2DM) but positively related to future cardiovascular disease (CVD). Recognizing that gestational diabetes (GDM) identifies women at future risk for both T2DM and CVD, we sought to determine whether gestational glucose tolerance relates to NT-proBNP in the years after delivery. DESIGN/PATIENTS/MEASUREMENTS: Three-hundred-and-forty women underwent a glucose challenge test (GCT) and an oral glucose tolerance test (OGTT) in pregnancy, yielding 4 gestational glucose tolerance groups: GDM (n=105); gestational impaired glucose tolerance (n=59); abnormal GCT with a normal OGTT (n=98); and normal GCT with normal OGTT (n=75)...
November 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29112780/associations-of-lifestyle-factors-with-serum-dehydroepiandrosterone-sulfate-and-insulin-like-growth-factor-1-concentration-in-prepubertal-children
#7
Aino Mäntyselkä, Jarmo Jääskeläinen, Aino-Maija Eloranta, Juuso Väistö, Raimo Voutilainen, Ken Ong, Soren Brage, Timo A Lakka, Virpi Lindi
OBJECTIVE: Little is known about the relationships of dietary factors, physical activity, and sedentary behavior to dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children. DESIGN AND SUBJECTS: Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years. MEASUREMENTS: Assessment of dietary factors by food records and physical activity and sedentary behavior by a combined heart rate and movement monitor and a questionnaire...
November 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29106701/use-of-salivary-cortisol-and-cortisone-in-the-high-and-low-dose-synacthen-test
#8
Charlotte J Elder, Robert F Harrison, Alexandra S Cross, Ruben Vilela, Brian G Keevil, Neil P Wright, Richard J Ross
CONTEXT: Salivary cortisone reflects serum cortisol levels, is more sensitive than salivary cortisol at lower values of serum cortisol and is non-invasive. OBJECTIVE: To investigate the relationship between serum cortisol and salivary cortisol and cortisone following low and high-dose synacthen. DESIGN AND SETTING: Prospective pharmacodynamic studies in clinical research facilities. PARTICIPANTS AND INTERVENTION: 35 dexamethasone-suppressed, healthy adult males underwent an intravenous synacthen test: N=23 low-dose (1mcg), N=12 high-dose (250mcg)...
November 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29095527/clinical-guidance-for-radioiodine-refractory-differentiated-thyroid-cancer
#9
Matti L Gild, Duncan J Topliss, Diana Learoyd, Francis Parnis, Jeanne Tie, Brett Hughes, John P Walsh, Donald Sa McLeod, Roderick J Clifton-Bligh, Bruce G Robinson
Prognosis from differentiated thyroid cancer is worse when the disease becomes refractory to radioiodine. Until recently, treatment options have been limited to local therapies such as surgery and radiotherapy, but the recent availability of systemic therapies now provides some potential for disease control. Multi-targeted kinase inhibitors (TKIs) including lenvatinib and sorafenib have been shown to improve progression free survival in Phase III clinical trials, but are also associated with a spectrum of adverse effects...
November 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29095521/vitamin-d-and-calcium-supplementation-skeletal-muscle-strength-and-serum-testosterone-in-young-healthy-adult-males-randomized-control-trial
#10
Soma Saha, Ravinder Goswami, Lakshmy Ramakrishnan, Vishnubhatla Sreenivas, Samrina Mahtab, Parmita Kar, Sunita Srinivasan, Namrata Singh, Upinderpal Singh
BACKGROUND: Cholecalciferol and/or calcium supplementation might increase skeletal-muscle strength and serum testosterone in young adult males. OBJECTIVE: We performed a randomized-control-trial assessing the effect of cholecalciferol/calcium on skeletal-muscle strength and serum testosterone in vitamin-D deficient young males. DESIGN: Two-by-two factorial RCT. SUBJECT AND INTERVENTION: Two-hundred and twenty-eight young males were block-randomized to 1) double-placebo, 2) calcium/placebo, 3) cholecalciferol/placebo, and 4) cholecalciferol/calcium...
November 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29083503/risk-factors-stratifying-malignancy-of-nodules-in-contralateral-thyroid-lobe-in-patients-with-preoperative-ultrasound-indicated-unilateral-papillary-thyroid-carcinoma-a-retrospective-analysis-from-single-center
#11
Tian Lv, Changbin Zhu, Zhongming Di
OBJECTIVE: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma with a favorable clinical outcome. For unilateral PTC patients with thyroid nodules in the contralateral lobes, the necessity of total thyroidectomy (TT) is still in doubt. In this study, we aimed to define clinical factors that could be indicators for malignancy in nodules in the contralateral thyroid lobe, which could aid the clinician in selecting the appropriate operation approach. DESIGN, PATIENTS AND MEASUREMENTS: This is a retrospective study from Jan 2014 to Dec 2016 conducted in Shanghai Ruijin Hospital...
October 30, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29080355/tumour-lateralization-in-cushing-s-disease-by-inferior-petrosal-sinus-sampling-with-desmopressin
#12
Ming Feng, Ziyuan Liu, Xiaohai Liu, Xiaobo Zhang, Xinjie Bao, Yong Yao, Kan Deng, Bing Xing, Wei Lian, Huijuan Zhu, Lin Lu, Renzhi Wang
BACKGROUND: Bilateral inferior petrosal sinus sampling (IPSS) with corticotropin-releasing hormone (CRH) is currently the gold standard in the diagnosis of Cushing's disease (CD) and has also been used in tumour lateralization. Our objective was to determine the diagnostic value and lateralization accuracy of IPSS with desmopressin. METHODS: We retrospectively analyzed 91 patients with Cushing's syndrome who had either negative findings on pituitary dynamic enhanced magnetic resonance imaging (MRI) or non-suppressed high dose dexamethasone suppression tests (HDDST)...
October 28, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29078011/bone-mineral-density-in-familial-partial-lipodystrophy
#13
Antía Fernández-Pombo, Javier A Ossandon-Otero, Cristina Guillín-Amarelle, Sofía Sánchez-Iglesias, Ana I Castro, Blanca González-Méndez, Silvia Rodríguez-García, Leticia Rodriguez-Cañete, Felipe F Casanueva, David Araújo-Vilar
OBJECTIVE: Type 1 and type 2 familial partial lipodystrophies (FPLD) are characterized by the loss or increase of subcutaneous fat in certain body regions, as well as metabolic disorders. Higher muscle volume and mass have also been described. However, so far, possible bone involvement has not been studied. The aim of this study was to evaluate bone mineral density (BMD) in patients with type 1 and type 2 FPLD. METHODS: A total of 143 women were selected and distributed into three groups (17 women with FPLD2, 82 women with FPLD1 and 44 non-lipodystrophic obese female controls)...
October 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29067698/double-trouble-co-occurrence-of-testosterone-deficiency-and-body-fatness-associated-with-all-cause-mortality-in-us-men
#14
D S Lopez, X Qiu, S Advani, K K Tsilidis, M Khera, J Kim, A Morgentaler, R Wang, S Canfield
BACKGROUND: Testosterone deficiency (TD, total testosterone ≤ 350 ng/dL [12.15 nmol/L]) and obesity epidemic are growing in parallel in the United States. Yet the sequelae of TD and obesity on the risk of mortality remains unclear. OBJECTIVE: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥ 30 kg/m(2) ), and abdominal obesity (waist circumference ≥ 102 cm), is associated with a risk of all-cause mortality in American men...
October 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29055168/long-term-safety-of-growth-hormone-a-combined-registry-analysis
#15
Kirstine Stochholm, Wieland Kiess
OBJECTIVES: Preliminary data from the French cohort of the Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) study raised concerns regarding the safety of recombinant human GH, suggesting that GH may increase mortality and incidence of stroke in patients treated during childhood for GH deficiency or short stature. We evaluated published safety data, focusing on mortality, neoplasms, cerebrovascular events and diabetes across a number of large-scale pharmaceutical company GH registries...
October 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29055143/pasireotide-for-the-treatment-of-refractory-hypoglycemia-from-malignant-insulinoma
#16
Nicholas S Hendren, Kamaldeep Panach, Timothy J Brown, Lan Peng, Muhammad S Beg, Jonathan Weissler, Sasan Mirfakhraee
Insulinomas are rare, usually solitary benign tumors. The presence of metastases defines malignant insulinomas((1)) . Medical therapy primarily treats symptomatic hypoglycemia, alleviates symptoms, and improves the quality of life in affected individuals. While diazoxide is used as first-line therapy, the incomplete response rate and complications associated with diazoxide provide a role for somatostatin analogues in difficult-to-treat hypoglycemia. This article is protected by copyright. All rights reserved...
October 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29044636/an-inverse-association-between-serum-resistin-levels-and-n-3-polyunsaturated-fatty-acids-intake-was-strongest-in-the-snp-420-g-g-genotype-in-the-japanese-cohort-the-toon-genome-study
#17
Yukinobu Noumi, Ryoichi Kawamura, Yasuharu Tabara, Koutatsu Maruyama, Yasunori Takata, Wataru Nishida, Ai Okamoto, Tatsuya Nishimiya, Hiroshi Onuma, Isao Saito, Takeshi Tanigawa, Haruhiko Osawa
OBJECTIVE: Resistin is secreted from monocytes/macrophages and is associated with insulin resistance, inflammation, and cardiovascular diseases. In the Japanese cohort, serum resistin is tightly associated with a single nucleotide polymorphism (SNP) at -420 (rs1862513) in the promoter region of the human resistin gene. However, interactions between SNP-420 and environmental factors remain to be elucidated. The aim of this study was to investigate the association between serum resistin levels and nutrient intake, and the effect of SNP-420 on this association...
October 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29044586/males-with-prolactinoma-are-at-increased-risk-of-incident-cardiovascular-disease
#18
Konstantinos A Toulis, Tim Robbins, Narendra Reddy, Balachandran Kumarendran, Krishna Gokhale, Haren Wijesinghe, Kar Keung Cheng, Niki Karavitaki, John Wass, Krishnarajah Nirantharakumar
OBJECTIVE: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma. DESIGN: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database. PATIENTS: 2,233 patients with prolactinoma and 10,355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Sex, age, body mass index, and smoking status were used as matching parametres...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29044581/women-with-polycystic-ovary-syndrome-demonstrate-worsening-markers-of-cardiovascular-risk-over-the-short-term-despite-declining-hyperandrogenaemia-results-of-a-longitudinal-study-with-community-controls
#19
Heather G Huddleston, Molly M Quinn, Chia-Ning Kao, Nikolaus Lenhart, Mitchell P Rosen, Marcelle I Cedars
OBJECTIVE: To compare age-associated changes in cardiovascular risk markers in lean and obese reproductive-aged women with polycystic ovary syndrome (PCOS) with community controls DESIGN: Longitudinal study at an academic medical centre. PATIENTS: Patients diagnosed with PCOS by 2004 Rotterdam criteria in a multi-disciplinary clinic were systematically enrolled from 2006-2014 in a PCOS cohort study and subsequently agreed to participate in a longitudinal study. The comparison controls were from the prospective, longitudinal Ovarian Aging (OVA) study, which consists of healthy women with regular menstrual cycles recruited from 2006 to 2011...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29044573/higher-igfb3-is-associated-with-increased-incidence-of-colorectal-cancer-in-older-men-independently-of-igf1
#20
Yi X Chan, Helman Alfonso, Stephen Anthony Paul Chubb, Ken K Y Ho, Peter Gerard Fegan, Graeme J Hankey, Jonathan Golledge, Leon Flicker, Bu B Yeap
OBJECTIVE: Insulin-like growth factor 1 (IGF1) has anabolic and growth-promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk. DESIGN: A prospective cohort study of 4042 men aged ≥70 years. METHODS: Plasma total IGF1, IGFBP1 and IGFBP3 were measured between 2001 and 2004...
October 16, 2017: Clinical Endocrinology
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