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Upsala Journal of Medical Sciences

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https://www.readbyqxmd.com/read/28436719/gambling-frequency-and-symptoms-of-attention-deficit-hyperactivity-disorder-in-relation-to-problem-gambling-among-swedish-adolescents-a-population-based-study
#1
Charlotta Hellström, Philippe Wagner, Kent W Nilsson, Jerzy Leppert, Cecilia Åslund
AIM: To investigate the associations between gambling frequency, attention-deficit hyperactivity disorder (ADHD) symptoms, and problem gambling among adolescent boys and girls. One hypothesis was that adolescents with increased ADHD symptoms have a higher frequency of gambling compared to adolescents with fewer ADHD symptoms. METHOD: A population-based sample of adolescents (aged 15-18 years) completed a questionnaire on demographics, gambling habits, ADHD symptoms, and problematic gambling; 1412 adolescents (from 4440 sampled) with gambling experience were included in the final sample...
April 24, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28434271/minimizing-atelectasis-formation-during-general-anaesthesia-oxygen-washout-is-a-non-essential-supplement-to-peep
#2
Erland Östberg, Udo Auner, Mats Enlund, Henrik Zetterström, Lennart Edmark
BACKGROUND: Following preoxygenation and induction of anaesthesia, most patients develop atelectasis. We hypothesized that an immediate restoration to a low oxygen level in the alveoli would prevent atelectasis formation and improve oxygenation during the ensuing anaesthesia. METHODS: We randomly assigned 24 patients to either a control group (n = 12) or an intervention group (n = 12) receiving an oxygen washout procedure directly after intubation. Both groups were, depending on body mass index, ventilated with a positive end-expiratory pressure (PEEP) of 6-8 cmH2O during surgery...
April 24, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28291376/cardioversion-of-atrial-fibrillation-does-not-affect-obstructive-sleep-apnea
#3
Niklas Höglund, Carin Sahlin, Milos Kesek, Steen M Jensen, Karl A Franklin
BACKGROUND: Sleep apnea is common in patients with atrial fibrillation, but the effect of the cardioversion of atrial fibrillation to sinus rhythm on central and obstructive apneas is mainly unknown. The primary aim of the study was to analyze the association between cardioversion of atrial fibrillation and sleep apneas, to investigate whether obstructive or central sleep apneas are reduced following cardioversion. A secondary objective was to study the effect on sleep quality. METHODS: Twenty-three patients with atrial fibrillation were investigated using overnight polysomnography, including esophagus pressure monitoring and ECG, before and after the cardioversion of persistent atrial fibrillation...
March 14, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276781/association-between-numbers-of-decayed-teeth-and-hba1c-in-japanese-patients-with-type-2-diabetes-mellitus
#4
Satoru Yonekura, Masato Usui, Shunichi Murano
BACKGROUND: Dental caries (DC) are more prevalent in individuals with diabetes than in healthy individuals. However, the association between glycaemic control and DC has not been well characterized in patients with type 2 diabetes mellitus (T2DM). We therefore assessed the association between glycated haemoglobin (HbA1c) serum concentrations and the prevalence of DC in patients with T2DM. METHODS: Retrospective analyses of data pertaining to 108 Japanese patients with T2DM hospitalized because of poor or worsened glycaemic control were included...
March 3, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276780/utility-of-registries-for-post-marketing-evaluation-of-medicines-a-survey-of-swedish-health-care-quality-registries-from-a-regulatory-perspective
#5
Nils Feltelius, Rolf Gedeborg, Lennart Holm, Björn Zethelius
AIM: The aim of this study was to describe content and procedures in some selected Swedish health care quality registries (QRs) of relevance to regulatory decision-making. METHODS: A workshop was organized with participation of seven Swedish QRs which subsequently answered a questionnaire regarding registry content on drug treatments and outcomes. Patient populations, coverage, data handling and quality control, as well as legal and ethical aspects are presented...
March 3, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276779/development-of-new-levodopa-treatment-strategies-in-parkinson-s-disease-from-bedside-to-bench-to-bedside
#6
Sten-Magnus Aquilonius, Dag Nyholm
This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been developed in collaborative research within departments at Uppsala University. With this historical approach, reference priority is given to reports considered to be of special importance for this more than two decades long process 'from bedside to bench to bedside'...
March 3, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276782/respiratory-symptoms-and-lung-function-in-relation-to-wood-dust-and-monoterpene-exposure-in-the-wood-pellet-industry
#7
Håkan Löfstedt, Katja Hagström, Ing-Liss Bryngelsson, Mats Holmström, Anna Rask-Andersen
INTRODUCTION: Wood pellets are used as a source of renewable energy for heating purposes. Common exposures are wood dust and monoterpenes, which are known to be hazardous for the airways. The purpose of this study was to study the effect of occupational exposure on respiratory health in wood pellet workers. MATERIALS AND METHODS: Thirty-nine men working with wood pellet production at six plants were investigated with a questionnaire, medical examination, allergy screening, spirometry, and nasal peak expiratory flow (nasal PEF)...
March 1, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28256956/on-a-prolonged-interval-between-rectal-cancer-chemo-radiotherapy-and-surgery
#8
Bengt Glimelius
Preoperative radiotherapy (RT) or chemoradiotherapy (CRT) is often required before rectal cancer surgery to obtain low local recurrence rates or, in locally advanced tumours, to radically remove the tumour. RT/CRT in tumours responding completely can allow an organ-preserving strategy. The time from the end of the RT/CRT to surgery or to the decision not to operate has been prolonged during recent years. After a brief review of the literature, the relevance of the time interval to surgery is discussed depending upon the indication for RT/CRT...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28256955/preconception-genetic-carrier-screening-use-and-problems
#9
Viroj Wiwanitkit
No abstract text is available yet for this article.
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28145795/supernumerary-human-hair-cells-signs-of-regeneration-or-impaired-development-a-field-emission-scanning-electron-microscopy-study
#10
Helge Rask-Andersen, Hao Li, Hubert Löwenheim, Marcus Müller, Kristian Pfaller, Annelies Schrott-Fischer, Rudolf Glueckert
BACKGROUND: Current attempts to regenerate cochlear sensorineural structures motivate further inspection of the human organ of hearing. Here, we analyzed the supernumerary inner hair cell (sIHC), a possible sign of regeneration and cell replacement. METHODS: Human cochleae were studied using field emission scanning electron microscopy (FESEM; maximum resolution 2 nm) obtained from individuals aged 44, 48, and 58 years with normal sensorineural pure-tone average (PTA) thresholds (PTA <20 dB)...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27894208/whole-body-mri-including-diffusion-weighted-mri-compared-with-5-htp-pet-ct-in-the-detection-of-neuroendocrine-tumors
#11
Lina Carlbom, José Caballero-Corbalán, Dan Granberg, Jens Sörensen, Barbro Eriksson, Håkan Ahlström
AIM: We wanted to explore if whole-body magnetic resonance imaging (MRI) including diffusion-weighted (DW) and liver-specific contrast agent-enhanced imaging could be valuable in lesion detection of neuroendocrine tumors (NET). [11C]-5-Hydroxytryptophan positron emission tomography/computed tomography (5-HTP PET/CT) was used for comparison. MATERIALS AND METHODS: Twenty-one patients with NET were investigated with whole-body MRI, including DW imaging (DWI) and contrast-enhanced imaging of the liver, and whole-body 5-HTP PET/CT...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27849141/eight-year-follow-up-of-airway-hyperresponsiveness-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#12
Dora Ludviksdottir, Sigridur Th Valtysdottir, Hans Hedenström, Roger Hällgren, Björn Gudbjörnsson
OBJECTIVE: To evaluate in a longitudinal study the influence of airway hyperresponsiveness (AHR) on lung function in patients with primary Sjögren's syndrome (pSS). METHODS: Lung function was studied over an eight-year period in 15 patients who fulfilled the Copenhagen criteria for primary Sjögren's syndrome and who were covered in our earlier published study on AHR in patients with Sjögren's syndrome. Standard spirometry and measurements of lung volumes, diffusing capacity (DLCO), and AHR to methacholine were performed...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27849129/reduced-obstacles-maximized-vision-romv-a-new-technique-to-facilitate-laryngoscopy-for-endotracheal-intubation
#13
Mohammad Kharazmi, Håkan Scheer, Pär Hallberg
No abstract text is available yet for this article.
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27739337/utility-of-bronchoalveolar-lavage-in-diagnosing-respiratory-tract-infections-in-patients-with-hematological-malignancies-are-invasive-diagnostics-still-needed
#14
Tobias Svensson, Kristina Lamberg Lundström, Martin Höglund, Honar Cherif
BACKGROUND: Patients treated for hematological malignancies have an increased risk of serious infections. Diagnosis and prompt initiation of therapy are essential. Bronchoalveolar lavage (BAL) is a well-established investigation for identifying the cause of pulmonary infiltrates in immunocompromised patients. The aim of the study was to determine the diagnostic yield of BAL in patients treated for hematological malignancies and how often it contributed to a modification of the anti-infectious therapy...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27690722/differential-neutrophil-chemotactic-response-towards-il-8-and-bacterial-n-formyl-peptides-in-term-newborn-infants
#15
Maria E Stålhammar, Lena Douhan Håkansson, Anders Jonzon, Richard Sindelar
BACKGROUND: A prerequisite for an effective innate immunity is the migrative ability of neutrophils to respond to inflammatory and infectious agents such as the intermediate interleukin (IL)-8 and the end-target formyl-methionyl-leucyl-phenylalanine (fMLP) chemoattractants. The aim was to study the chemotactic capacity of neutrophils from newborn infants and adults in response to IL-8 and the bacterial peptide fMLP. METHODS: In the under-agarose cell migration assay, isolated leukocytes from healthy adults and from cord blood of healthy term newborn infants were studied with dose responses towards IL-8 and fMLP...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27658527/pxl01-in-sodium-hyaluronate-results-in-increased-prg4-expression-a-potential-mechanism-for-anti-adhesion
#16
Sara Edsfeldt, Björn Holm, Margit Mahlapuu, Carol Reno, David A Hart, Monica Wiig
PURPOSE: To investigate the anti-adhesive mechanisms of PXL01 in sodium hyaluronate (HA) by using the rabbit lactoferrin peptide, rabPXL01 in HA, in a rabbit model of healing tendons and tendon sheaths. The mechanism of action for PXL01 in HA is interesting since a recent clinical study of the human lactoferrin peptide PXL01 in HA administered around repaired tendons in the hand showed improved digit mobility. MATERIALS AND METHODS: On days 1, 3, and 6 after tendon injury and surgical repair, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to assess mRNA expression levels for genes encoding the mucinous glycoprotein PRG4 (also called lubricin) and a subset of matrix proteins, cytokines, and growth factors involved in flexor tendon repair...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27628957/psychometric-evaluation-of-the-swedish-translation-of-the-revised-cystic-fibrosis-questionnaire-in-adults
#17
Jacek Hochwälder, Agneta Bergsten Brucefors, Lena Hjelte
AIM: The CFQ-R is one of the most established disease-specific, health-related quality of life (HRQOL) measurements for patients with cystic fibrosis (CF). The aim was to evaluate the psychometric properties of the Swedish translation of CFQ-R in adults. METHOD: A total of 173 CF patients answered the CFQ-R. The CFQ-R was evaluated with regard to: (1) distributional properties; (2) reliability; and (3) construct validity. RESULTS: The majority of scales were negatively skewed with ceiling effects...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27622962/low-dose-exposure-to-bisphenol-a-in-combination-with-fructose-increases-expression-of-genes-regulating-angiogenesis-and-vascular-tone-in-juvenile-fischer-344-rat-cardiac-tissue
#18
Helén Klint, Margareta H Lejonklou, Elina Karimullina, Monika Rönn, Lars Lind, P Monica Lind, Eva Brittebo
OBJECTIVES: Epidemiological studies report associations between exposure to the high-volume chemical and endocrine disruptor bisphenol A (BPA) and cardiovascular disorders, but there is a lack of experimental studies addressing the mechanisms of action of BPA on the cardiovascular system. In the present study, effects on markers for cardiovascular function of exposure to BPA and fructose in vivo in rat cardiac tissues, and of BPA exposure in human cardiomyocytes in vitro, were investigated...
March 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27760000/who-benefits-from-putting-family-life-into-ice
#19
Outi Hovatta
No abstract text is available yet for this article.
October 19, 2016: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27754727/scholarly-publishing-threatened
#20
Arne Andersson, Joey Lau Börjesson
No abstract text is available yet for this article.
October 18, 2016: Upsala Journal of Medical Sciences
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