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Upsala Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29536805/the-effect-of-the-first-generation-hcv-protease-inhibitors-boceprevir-and-telaprevir-and-the-relation-to-baseline-ns3-resistance-mutations-in-genotype-1-experience-from-a-small-swedish-cohort
#1
Midori Kjellin, Terése Wesslén, Erik Löfblad, Johan Lennerstrand, Anders Lannergård
BACKGROUND: The clinical experience with protease-inhibitor (PI) triple regimen appears disappointing regarding effect, side effects, high work load, and costs. This real-world study evaluates baseline and emerging resistance-associated substitutions (RASs) and their significance for treatment outcome. METHOD: Thirty-six genotype 1a/b patients treated according to Swedish recommendations during 2011-2013 with triple therapy including pegylated interferon and ribavirin in combination with a protease-inhibitor, either boceprevir (BOC) or telaprevir (TVR), were retrospectively evaluated...
March 14, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29493383/mir-130a-is-aberrantly-overexpressed-in-adult-acute-myeloid-leukemia-with-t-8-21-and-its-suppression-induces-aml-cell-death
#2
Chao Ding, Su-Ning Chen, Roderick A F Macleod, Hans G Drexler, Stefan Nagel, De-Pei Wu, Ai-Ning Sun, Hai-Ping Dai
BACKGROUND: Emerging evidence has revealed that miRNAs can function as oncogenes or tumor suppressor genes in leukemia. The ectopic expression of miR-130a has been reported in chronic leukemia, but our understanding of the biological implications of miR-130a expression remains incomplete. METHODS: We quantified a cohort of de novo acute myeloid leukemia (AML) by bead-based miRNA and real-time quantitative PCR (Rq-PCR). The luciferase reporter gene assay was analyzed after the plasmid constructs which contain 5'-UTR of miR-130a and a Renilla luciferase reporter plasmid were transfected simultaneously into 293T cells...
March 1, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29485932/do-we-have-scientific-evidence-about-the-effect-of-hypoxaemia-on-cognitive-outcome-in-adult-patients-with-severe-acute-respiratory-failure
#3
Bernhard Holzgraefe, Anders Larsson, Laura Von Kobyletzki
No abstract text is available yet for this article.
February 27, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29482431/microrna-meta-signature-of-oral-cancer-evidence-from-a-meta-analysis
#4
Katarina Zeljic, Ivan Jovanovic, Jasmina Jovanovic, Zvonko Magic, Aleksandra Stankovic, Gordana Supic
AIM: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. MATERIAL AND METHODS: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. RESULTS: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue...
February 26, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29436895/a-model-to-study-complement-involvement-in-experimental-retinal-degeneration
#5
Camilla Mohlin, Kerstin Sandholm, Anders Kvanta, Kristina N Ekdahl, Kjell Johansson
BACKGROUND: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseases, including diabetic retinopathy (DR), glaucoma, uveitis, and age-related macular degeneration (AMD). Given that many of the complex eye-related degenerative diseases have limited treatment opportunities, we aimed to mimic the in vivo retinal degenerative process by developing a relevant co-culture system. METHOD AND MATERIALS: The adult porcine retina was co-cultured with the spontaneously arising human retinal pigment epithelial cells-19 (ARPE-19)...
February 13, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29537931/the-secondary-spiral-lamina-and-its-relevance-in-cochlear-implant-surgery
#6
Sumit Agrawal, Nadine Schart-Morén, Wei Liu, Hanif M Ladak, Helge Rask-Andersen, Hao Li
OBJECTIVE: We used synchrotron radiation phase contrast imaging (SR-PCI) to study the 3D microanatomy of the basilar membrane (BM) and its attachment to the spiral ligament (SL) (with a conceivable secondary spiral lamina [SSL] or secondary spiral plate) at the round window membrane (RWM) in the human cochlea. The conception of this complex anatomy may be essential for accomplishing structural preservation at cochlear implant surgery. MATERIAL AND METHODS: Sixteen freshly fixed human temporal bones were used to reproduce the BM, SL, primary and secondary osseous spiral laminae (OSL), and RWM using volume-rendering software...
March 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29495912/more-secure-attachment-to-the-father-and-the-mother-is-associated-with-fewer-depressive-symptoms-in-adolescents
#7
Birgitta Kerstis, Cecilia Åslund, Karin Sonnby
AIM: To investigate whether more secure attachment to the father and the mother is associated with less depressive symptoms among adolescents, and to explore possible sex differences. METHOD: A population-based sample of adolescents completed a school-based survey assessing demographic data, attachment to father and mother, as well as depressive symptoms. Participation rate was 80% of the eligible population, and 3,988 adolescents (1,937 boys and 2,051 girls) had complete data for the analyses...
March 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29473432/human-neutrophil-lipocalin-hnl-as-a-biomarker-of-acute-infections
#8
Per Venge
The early and accurate discrimination between bacterial and viral causes of acute infections is the key to a better use of antibiotics and will help slow down the fast-growing resistance to commonly used antibiotics. This discrimination is in the vast majority of cases possible to achieve by blood assay of the biomarker human neutrophil lipocalin (HNL), which we showed to be uniquely increased in patients suffering from bacterial infections. In serum, sensitivities and specificities of >90% are achieved in both adults and children...
March 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29363386/increased-psoriasis-frequency-in-patients-with-familial-mediterranean-fever
#9
Abdulsamet Erden, Ezgi Deniz Batu, Emrah Seyhoğlu, Alper Sari, Hafize Emine Sönmez, Berkan Armagan, Selcan Demir, Emre Bilgin, Levent Kilic, Omer Karadag, Ali Akdogan, Yelda Bilginer, Ihsan Ertenli, Sedat Kiraz, Sule Apras Bilgen, Umut Kalyoncu
OBJECTIVE: Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by MEFV mutations. FMF may be associated with psoriasis in some cases. The prevalence of psoriasis in the normal Turkish population is 0.42%. We aimed to investigate the prevalence of psoriasis among FMF patients and their relatives. METHODS: FMF patients followed at Hacettepe University Adult and Pediatric Rheumatology Departments between January and August 2016 were included. FMF patients/their relatives were accepted to have psoriasis if the diagnosis was made by a dermatologist...
March 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29338500/henry-johansson-in-memoriam
#10
Lars Grimelius, Göran Åkerström
No abstract text is available yet for this article.
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29338499/a-milestone-reached
#11
EDITORIAL
Arne Andersson
No abstract text is available yet for this article.
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303622/genotype-based-recall-to-study-metabolic-effects-of-genetic-variation-a-pilot-study-of-pparg-pro12ala-carriers
#12
Prasad G Kamble, Stefan Gustafsson, Maria J Pereira, Per Lundkvist, Naomi Cook, Lars Lind, Paul W Franks, Tove Fall, Jan W Eriksson, Erik Ingelsson
AIM: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of genotype-phenotype relationships. METHODS: We genotyped 2500 participants from the Swedish EpiHealth cohort and considered loss-of-function and missense variants in genes with relation to cardiometabolic traits as the basis for our GBR study. Therefore, we focused on carriers and non-carriers of the PPARG Pro12Ala (rs1801282) variant, as it is a relatively common variant with a minor allele frequency (MAF) of 0...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299974/do-pregnant-women-want-to-know-the-sex-of-the-expected-child-at-routine-ultrasound-and-are-they-interested-in-sex-selection
#13
Margareta Larsson, Minna Berglund, Emelie Jarl, Tanja Tydén
BACKGROUND: The aim of the study was to investigate if expecting parents wanted to know the sex of the fetus during ultrasound examination and if they had discussed it with the midwife. Another aim was to explore any interest in sex selection. METHODS: A longitudinal survey in early and late pregnancy among 2393 women in Sweden. RESULTS: Almost all (95.8%, n = 2289) women had discussed sex determination with the partner before the ultrasound scan, and 57% (n = 1356) of women and their partners wanted to find out the fetal sex...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299973/how-anaesthesiologists-understand-difficult-airway-guidelines-an-interview-study
#14
Kati Knudsen, Ulrika Pöder, Ulrica Nilsson, Marieann Högman, Anders Larsson, Jan Larsson
BACKGROUND: In the practice of anaesthesia, clinical guidelines that aim to improve the safety of airway procedures have been developed. The aim of this study was to explore how anaesthesiologists understand or conceive of difficult airway management algorithms. METHODS: A qualitative phenomenographic design was chosen to explore anaesthesiologists' views on airway algorithms. Anaesthesiologists working in three hospitals were included. Individual face-to-face interviews were conducted...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299972/molecular-size-and-charge-as-dimensions-to-identify-and-characterize-circulating-glycoforms-of-human-fsh-lh-and-tsh
#15
Leif Wide, Karin Eriksson
BACKGROUND: FSH, LH, and TSH are glycoprotein hormones secreted from the pituitary as fully and low-asparagine-glycosylated hormones. These glycoforms of the hormones exist as a large number of isoforms varying in their glycan contents of terminal anionic monosaccharides (AMS), i.e. sialic acid (SA) and sulfonated N-acetylgalactosamine (SU). Due to the immense heterogeneity and the low concentrations in serum it has been a challenge to develop reliable analytical methods to measure and characterize the circulating glycoforms of these hormones...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299952/the-utility-of-coagulation-activity-for-prediction-of-risk-of-mortality-and-cardiovascular-events-in-guideline-treated-myocardial-infarction-patients
#16
Christina Christersson, Bertil Lindahl, Lars Berglund, Agneta Siegbahn, Jonas Oldgren
BACKGROUND: Despite improved treatment of myocardial infarction (MI), real-world patients still suffer substantial risk for subsequent cardiovascular events. Little is known about coagulation activity shortly after MI and whether coagulation activity markers may identify patients at increased risk despite contemporary treatment. OBJECTIVE: To evaluate D-dimer concentration and thrombin generation potential shortly after discharge after MI and evaluate if these markers could predict the risk of future cardiovascular and bleeding events...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29264992/redox-status-in-the-sentinel-lymph-node-of-women-with-breast-cancer
#17
María Jesús Ramírez-Expósito, Nieves Urbano-Polo, Basilio Dueñas, Joaquín Navarro-Cecilia, César Ramírez-Tortosa, María Dolores Martín-Salvago, José Manuel Martínez-Martos
BACKGROUND: Lymphatic metastasis is regulated in multiple steps including the transit of tumor cells via the lymphatic vessels and the successful seeding in draining lymph nodes. Thus, several molecular signals and cellular changes must be involved in this complex process to facilitate tumor cell entry, colonization, and survival in the lymph node. To our knowledge, the present work explores, for the first time in the literature, the redox status (oxidative stress parameters and enzymatic and non-enzymatic antioxidant defense systems) in the sentinel lymph node (SLN) of women with breast cancer...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29045168/possible-causes-of-experiencing-problems-with-sick-leave-questions-in-telephone-nursing
#18
Linda Lännerström, Inger K Holmström, Kurt Svärdsudd, Thorne Wallman
BACKGROUND: Registered nurses at primary health care centres in Sweden receive about 20 million telephone calls annually. Questions related to sick leave occur regularly. Previous studies conclude that those calls often are perceived as problematic. The aim of this study was to explore factors associated with problems regarding sick leave questions in telephone nursing. METHODS: A questionnaire was distributed to all registered nurses (n = 185) working with telephone nursing in 26 Swedish primary health care centres, of whom 114 (61...
November 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28980863/addition-of-exogenous-sodium-palmitate-increases-the-iapp-insulin-mrna-ratio-via-gpr40-in-human-endoc-%C3%AE-h1-cells
#19
Camilla Krizhanovskii, Rikard G Fred, Marie E Oskarsson, Gunilla T Westermark, Nils Welsh
BACKGROUND: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells. METHODS: EndoC-βH1 cells and human islets were cultured in the presence of sodium palmitate. Effects on IAPP/insulin mRNA expression and secretion were determined using real-time qPCR/ELISA. Pharmacological activators and/or inhibitors and RNAi were used to determine the underlying mechanisms...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28891412/a-novel-prothrombin-time-method-to-measure-all-non-vitamin-k-dependent-oral-anticoagulants-noacs
#20
Tomas L Lindahl, Kerstin Arbring, Maria Wallstedt, Mats Rånby
BACKGROUND: There is a clinical need for point-of-care (POC) methods for non-vitamin K-dependent oral anticoagulants (NOACs). We modified a routine POC procedure: Zafena's Simple Simon™ PT-INR, a room-temperature, wet-chemistry prothrombin time method of the Owren-type. METHODS: To either increase or decrease NOAC interference, two assay variants were devised by replacing the standard 10 µL end-to-end capillary used to add the citrated plasma sample to 200 µL of prothrombin time (PT) reagent by either a 20 µL or a 5 µL capillary...
August 2017: Upsala Journal of Medical Sciences
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