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Upsala Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29436895/a-model-to-study-complement-involvement-in-experimental-retinal-degeneration
#1
Camilla Mohlin, Kerstin Sandholm, Anders Kvanta, Kristina N Ekdahl, Kjell Johansson
BACKGROUND: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseases, including diabetic retinopathy (DR), glaucoma, uveitis, and age-related macular degeneration (AMD). Given that many of the complex eye-related degenerative diseases have limited treatment opportunities, we aimed to mimic the in vivo retinal degenerative process by developing a relevant co-culture system. METHOD AND MATERIALS: The adult porcine retina was co-cultured with the spontaneously arising human retinal pigment epithelial cells-19 (ARPE-19)...
February 13, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29363386/increased-psoriasis-frequency-in-patients-with-familial-mediterranean-fever
#2
Abdulsamet Erden, Ezgi Deniz Batu, Emrah Seyhoğlu, Alper Sari, Hafize Emine Sönmez, Berkan Armagan, Selcan Demir, Emre Bilgin, Levent Kilic, Omer Karadag, Ali Akdogan, Yelda Bilginer, Ihsan Ertenli, Sedat Kiraz, Sule Apras Bilgen, Umut Kalyoncu
OBJECTIVE: Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by MEFV mutations. FMF may be associated with psoriasis in some cases. The prevalence of psoriasis in the normal Turkish population is 0.42%. We aimed to investigate the prevalence of psoriasis among FMF patients and their relatives. METHODS: FMF patients followed at Hacettepe University Adult and Pediatric Rheumatology Departments between January and August 2016 were included. FMF patients/their relatives were accepted to have psoriasis if the diagnosis was made by a dermatologist...
January 24, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29338500/henry-johansson-in-memoriam
#3
Lars Grimelius, Göran Åkerström
No abstract text is available yet for this article.
January 17, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29338499/a-milestone-reached
#4
Arne Andersson
No abstract text is available yet for this article.
January 17, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303622/genotype-based-recall-to-study-metabolic-effects-of-genetic-variation-a-pilot-study-of-pparg-pro12ala-carriers
#5
Prasad G Kamble, Stefan Gustafsson, Maria J Pereira, Per Lundkvist, Naomi Cook, Lars Lind, Paul W Franks, Tove Fall, Jan W Eriksson, Erik Ingelsson
AIM: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of genotype-phenotype relationships. METHODS: We genotyped 2500 participants from the Swedish EpiHealth cohort and considered loss-of-function and missense variants in genes with relation to cardiometabolic traits as the basis for our GBR study. Therefore, we focused on carriers and non-carriers of the PPARG Pro12Ala (rs1801282) variant, as it is a relatively common variant with a minor allele frequency (MAF) of 0...
January 5, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299974/do-pregnant-women-want-to-know-the-sex-of-the-expected-child-at-routine-ultrasound-and-are-they-interested-in-sex-selection
#6
Margareta Larsson, Minna Berglund, Emelie Jarl, Tanja Tydén
BACKGROUND: The aim of the study was to investigate if expecting parents wanted to know the sex of the fetus during ultrasound examination and if they had discussed it with the midwife. Another aim was to explore any interest in sex selection. METHODS: A longitudinal survey in early and late pregnancy among 2393 women in Sweden. RESULTS: Almost all (95.8%, n = 2289) women had discussed sex determination with the partner before the ultrasound scan, and 57% (n = 1356) of women and their partners wanted to find out the fetal sex...
January 4, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299973/how-anaesthesiologists-understand-difficult-airway-guidelines-an-interview-study
#7
Kati Knudsen, Ulrika Pöder, Ulrica Nilsson, Marieann Högman, Anders Larsson, Jan Larsson
BACKGROUND: In the practice of anaesthesia, clinical guidelines that aim to improve the safety of airway procedures have been developed. The aim of this study was to explore how anaesthesiologists understand or conceive of difficult airway management algorithms. METHODS: A qualitative phenomenographic design was chosen to explore anaesthesiologists' views on airway algorithms. Anaesthesiologists working in three hospitals were included. Individual face-to-face interviews were conducted...
January 4, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299972/molecular-size-and-charge-as-dimensions-to-identify-and-characterize-circulating-glycoforms-of-human-fsh-lh-and-tsh
#8
Leif Wide, Karin Eriksson
BACKGROUND: FSH, LH, and TSH are glycoprotein hormones secreted from the pituitary as fully and low-asparagine-glycosylated hormones. These glycoforms of the hormones exist as a large number of isoforms varying in their glycan contents of terminal anionic monosaccharides (AMS), i.e. sialic acid (SA) and sulfonated N-acetylgalactosamine (SU). Due to the immense heterogeneity and the low concentrations in serum it has been a challenge to develop reliable analytical methods to measure and characterize the circulating glycoforms of these hormones...
January 4, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299952/the-utility-of-coagulation-activity-for-prediction-of-risk-of-mortality-and-cardiovascular-events-in-guideline-treated-myocardial-infarction-patients
#9
Christina Christersson, Bertil Lindahl, Lars Berglund, Agneta Siegbahn, Jonas Oldgren
BACKGROUND: Despite improved treatment of myocardial infarction (MI), real-world patients still suffer substantial risk for subsequent cardiovascular events. Little is known about coagulation activity shortly after MI and whether coagulation activity markers may identify patients at increased risk despite contemporary treatment. OBJECTIVE: To evaluate D-dimer concentration and thrombin generation potential shortly after discharge after MI and evaluate if these markers could predict the risk of future cardiovascular and bleeding events...
January 4, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29264992/redox-status-in-the-sentinel-lymph-node-of-women-with-breast-cancer
#10
María Jesús Ramírez-Expósito, Nieves Urbano-Polo, Basilio Dueñas, Joaquín Navarro-Cecilia, César Ramírez-Tortosa, María Dolores Martín-Salvago, José Manuel Martínez-Martos
BACKGROUND: Lymphatic metastasis is regulated in multiple steps including the transit of tumor cells via the lymphatic vessels and the successful seeding in draining lymph nodes. Thus, several molecular signals and cellular changes must be involved in this complex process to facilitate tumor cell entry, colonization, and survival in the lymph node. To our knowledge, the present work explores, for the first time in the literature, the redox status (oxidative stress parameters and enzymatic and non-enzymatic antioxidant defense systems) in the sentinel lymph node (SLN) of women with breast cancer...
December 21, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29045168/possible-causes-of-experiencing-problems-with-sick-leave-questions-in-telephone-nursing
#11
Linda Lännerström, Inger K Holmström, Kurt Svärdsudd, Thorne Wallman
BACKGROUND: Registered nurses at primary health care centres in Sweden receive about 20 million telephone calls annually. Questions related to sick leave occur regularly. Previous studies conclude that those calls often are perceived as problematic. The aim of this study was to explore factors associated with problems regarding sick leave questions in telephone nursing. METHODS: A questionnaire was distributed to all registered nurses (n = 185) working with telephone nursing in 26 Swedish primary health care centres, of whom 114 (61...
October 18, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28980863/addition-of-exogenous-sodium-palmitate-increases-the-iapp-insulin-mrna-ratio-via-gpr40-in-human-endoc-%C3%AE-h1-cells
#12
Camilla Krizhanovskii, Rikard G Fred, Marie E Oskarsson, Gunilla T Westermark, Nils Welsh
BACKGROUND: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells. METHODS: EndoC-βH1 cells and human islets were cultured in the presence of sodium palmitate. Effects on IAPP/insulin mRNA expression and secretion were determined using real-time qPCR/ELISA. Pharmacological activators and/or inhibitors and RNAi were used to determine the underlying mechanisms...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28891412/a-novel-prothrombin-time-method-to-measure-all-non-vitamin-k-dependent-oral-anticoagulants-noacs
#13
Tomas L Lindahl, Kerstin Arbring, Maria Wallstedt, Mats Rånby
BACKGROUND: There is a clinical need for point-of-care (POC) methods for non-vitamin K-dependent oral anticoagulants (NOACs). We modified a routine POC procedure: Zafena's Simple Simon™ PT-INR, a room-temperature, wet-chemistry prothrombin time method of the Owren-type. METHODS: To either increase or decrease NOAC interference, two assay variants were devised by replacing the standard 10 µL end-to-end capillary used to add the citrated plasma sample to 200 µL of prothrombin time (PT) reagent by either a 20 µL or a 5 µL capillary...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28826360/placental-location-postpartum-hemorrhage-and-retained-placenta-in-women-with-a-previous-cesarean-section-delivery-a-prospective-cohort-study
#14
Johanna Belachew, Karin Eurenius, Ajlana Mulic-Lutvica, Ove Axelsson
OBJECTIVE: Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women. MATERIALS AND METHODS: We performed a prospective cohort study on 400 women with cesarean section delivery in a previous pregnancy. Ultrasound examinations were performed at gestational week 28-30, and placental location, myometrial thickness, and three-dimensional vascularization index (VI) were recorded...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28814152/distant-metastasis-in-patients-with-myxofibrosarcoma
#15
Hiroyuki Tsuchie, Mitsunori Kaya, Hiroyuki Nagasawa, Makoto Emori, Yasutaka Murahashi, Emi Mizushima, Naohisa Miyakoshi, Toshihiko Yamashita, Yoichi Shimada
PURPOSE: A clinical feature of myxofibrosarcoma is local recurrence, but knowledge about distant metastasis is sparse. We evaluated the tendency of clinical and histological features of metastasis in myxofibrosarcoma patients. METHODS: Fifty-eight patients with myxofibrosarcoma were treated in our hospitals, and a total of 16 consecutive patients with distant metastases were included in this retrospective study (9 males and 7 females, with a mean age of 77 years)...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28814132/islet-amyloid-in-recent-onset-type-1-diabetes-the-divid-study
#16
Gunilla T Westermark, Lars Krogvold, Knut Dahl-Jørgensen, Johnny Ludvigsson
No abstract text is available yet for this article.
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28718697/pain-drawings-predict-outcome-of-surgical-treatment-for-degenerative-disc-disease-in-the-cervical-spine
#17
Anna MacDowall, Yohan Robinson, Martin Skeppholm, Claes Olerud
INTRODUCTION: Pain drawings have been frequently used in the preoperative evaluation of spine patients. For lumbar conditions comprehensive research has established both the reliability and predictive value, but for the cervical spine most of this knowledge is lacking. The aims of this study were to validate pain drawings for the cervical spine, and to investigate the predictive value for treatment outcome of four different evaluation methods. METHODS: We carried out a post hoc analysis of a randomized controlled trial, comparing cervical disc replacement to fusion for radiculopathy related to degenerative disc disease...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28513246/molecular-composition-and-distribution-of-gap-junctions-in-the-sensory-epithelium-of-the-human-cochlea-a-super-resolution-structured-illumination-microscopy-sr-sim-study
#18
Wei Liu, Hao Li, Fredrik Edin, Johan Brännström, Rudolf Glueckert, Annelies Schrott-Fischer, Matyas Molnar, Dirk Pacholsky, Kristian Pfaller, Helge Rask-Andersen
BACKGROUND: Mutations in the GJB2 gene, which encodes the Connexin26 (Cx26) protein, are the most common cause of childhood hearing loss in American and European populations. The cochlea contains a gap junction (GJ) network in the sensory epithelium and two connective tissue networks in the lateral wall and spiral limbus. The syncytia contain the GJ proteins beta 2 (GJB2/Cx26) and beta 6 (GJB6/Cx30). Our knowledge of their expression in humans is insufficient due to the limited availability of tissue...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28463046/the-influence-of-hyperthermia-on-intracranial-pressure-cerebral-oximetry-and-cerebral-metabolism-in-traumatic-brain-injury
#19
Lena Nyholm, Tim Howells, Anders Lewén, Lars Hillered, Per Enblad
BACKGROUND: Hyperthermia is a common secondary insult in traumatic brain injury (TBI). The aim was to evaluate the relationship between hyperthermia and intracranial pressure (ICP), and if intracranial compliance and cerebral blood flow (CBF) pressure autoregulation affected that relationship. The relationships between hyperthermia and cerebral oximetry (BtipO2) and cerebral metabolism were also studied. METHODS: A computerized multimodality monitoring system was used for data collection at the neurointensive care unit...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28503982/anxiety-and-depression-affect-pain-drawings-in-cervical-degenerative-disc-disease
#20
Anna MacDowall, Yohan Robinson, Martin Skeppholm, Claes Olerud
INTRODUCTION: Pain drawings have been frequently used in the preoperative evaluation of spine patients. Until now most investigations have focused on low back pain patients, even though pain drawings are used in neck pain patients as well. The aims of this study were to investigate the pain drawing and its association to preoperative demographics, psychological impairment, and pain intensity. METHODS: We carried out a post hoc analysis of a randomized controlled trial, comparing cervical disc replacement to fusion for radiculopathy related to degenerative disc disease...
June 2017: Upsala Journal of Medical Sciences
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