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Upsala Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29045168/possible-causes-of-experiencing-problems-with-sick-leave-questions-in-telephone-nursing
#1
Linda Lännerström, Inger K Holmström, Kurt Svärdsudd, Thorne Wallman
BACKGROUND: Registered nurses at primary health care centres in Sweden receive about 20 million telephone calls annually. Questions related to sick leave occur regularly. Previous studies conclude that those calls often are perceived as problematic. The aim of this study was to explore factors associated with problems regarding sick leave questions in telephone nursing. METHODS: A questionnaire was distributed to all registered nurses (n = 185) working with telephone nursing in 26 Swedish primary health care centres, of whom 114 (61...
October 18, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28980863/addition-of-exogenous-sodium-palmitate-increases-the-iapp-insulin-mrna-ratio-via-gpr40-in-human-endoc-%C3%AE-h1-cells
#2
Camilla Krizhanovskii, Rikard G Fred, Marie E Oskarsson, Gunilla T Westermark, Nils Welsh
BACKGROUND: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells. METHODS: EndoC-βH1 cells and human islets were cultured in the presence of sodium palmitate. Effects on IAPP/insulin mRNA expression and secretion were determined using real-time qPCR/ELISA. Pharmacological activators and/or inhibitors and RNAi were used to determine the underlying mechanisms...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28891412/a-novel-prothrombin-time-method-to-measure-all-non-vitamin-k-dependent-oral-anticoagulants-noacs
#3
Tomas L Lindahl, Kerstin Arbring, Maria Wallstedt, Mats Rånby
BACKGROUND: There is a clinical need for point-of-care (POC) methods for non-vitamin K-dependent oral anticoagulants (NOACs). We modified a routine POC procedure: Zafena's Simple Simon™ PT-INR, a room-temperature, wet-chemistry prothrombin time method of the Owren-type. METHODS: To either increase or decrease NOAC interference, two assay variants were devised by replacing the standard 10 µL end-to-end capillary used to add the citrated plasma sample to 200 µL of prothrombin time (PT) reagent by either a 20 µL or a 5 µL capillary...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28826360/placental-location-postpartum-hemorrhage-and-retained-placenta-in-women-with-a-previous-cesarean-section-delivery-a-prospective-cohort-study
#4
Johanna Belachew, Karin Eurenius, Ajlana Mulic-Lutvica, Ove Axelsson
OBJECTIVE: Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women. MATERIALS AND METHODS: We performed a prospective cohort study on 400 women with cesarean section delivery in a previous pregnancy. Ultrasound examinations were performed at gestational week 28-30, and placental location, myometrial thickness, and three-dimensional vascularization index (VI) were recorded...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28814152/distant-metastasis-in-patients-with-myxofibrosarcoma
#5
Hiroyuki Tsuchie, Mitsunori Kaya, Hiroyuki Nagasawa, Makoto Emori, Yasutaka Murahashi, Emi Mizushima, Naohisa Miyakoshi, Toshihiko Yamashita, Yoichi Shimada
PURPOSE: A clinical feature of myxofibrosarcoma is local recurrence, but knowledge about distant metastasis is sparse. We evaluated the tendency of clinical and histological features of metastasis in myxofibrosarcoma patients. METHODS: Fifty-eight patients with myxofibrosarcoma were treated in our hospitals, and a total of 16 consecutive patients with distant metastases were included in this retrospective study (9 males and 7 females, with a mean age of 77 years)...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28814132/islet-amyloid-in-recent-onset-type-1-diabetes-the-divid-study
#6
Gunilla T Westermark, Lars Krogvold, Knut Dahl-Jørgensen, Johnny Ludvigsson
No abstract text is available yet for this article.
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28718697/pain-drawings-predict-outcome-of-surgical-treatment-for-degenerative-disc-disease-in-the-cervical-spine
#7
Anna MacDowall, Yohan Robinson, Martin Skeppholm, Claes Olerud
INTRODUCTION: Pain drawings have been frequently used in the preoperative evaluation of spine patients. For lumbar conditions comprehensive research has established both the reliability and predictive value, but for the cervical spine most of this knowledge is lacking. The aims of this study were to validate pain drawings for the cervical spine, and to investigate the predictive value for treatment outcome of four different evaluation methods. METHODS: We carried out a post hoc analysis of a randomized controlled trial, comparing cervical disc replacement to fusion for radiculopathy related to degenerative disc disease...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28513246/molecular-composition-and-distribution-of-gap-junctions-in-the-sensory-epithelium-of-the-human-cochlea-a-super-resolution-structured-illumination-microscopy-sr-sim-study
#8
Wei Liu, Hao Li, Fredrik Edin, Johan Brännström, Rudolf Glueckert, Annelies Schrott-Fischer, Matyas Molnar, Dirk Pacholsky, Kristian Pfaller, Helge Rask-Andersen
BACKGROUND: Mutations in the GJB2 gene, which encodes the Connexin26 (Cx26) protein, are the most common cause of childhood hearing loss in American and European populations. The cochlea contains a gap junction (GJ) network in the sensory epithelium and two connective tissue networks in the lateral wall and spiral limbus. The syncytia contain the GJ proteins beta 2 (GJB2/Cx26) and beta 6 (GJB6/Cx30). Our knowledge of their expression in humans is insufficient due to the limited availability of tissue...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28463046/the-influence-of-hyperthermia-on-intracranial-pressure-cerebral-oximetry-and-cerebral-metabolism-in-traumatic-brain-injury
#9
Lena Nyholm, Tim Howells, Anders Lewén, Lars Hillered, Per Enblad
BACKGROUND: Hyperthermia is a common secondary insult in traumatic brain injury (TBI). The aim was to evaluate the relationship between hyperthermia and intracranial pressure (ICP), and if intracranial compliance and cerebral blood flow (CBF) pressure autoregulation affected that relationship. The relationships between hyperthermia and cerebral oximetry (BtipO2) and cerebral metabolism were also studied. METHODS: A computerized multimodality monitoring system was used for data collection at the neurointensive care unit...
August 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28503982/anxiety-and-depression-affect-pain-drawings-in-cervical-degenerative-disc-disease
#10
Anna MacDowall, Yohan Robinson, Martin Skeppholm, Claes Olerud
INTRODUCTION: Pain drawings have been frequently used in the preoperative evaluation of spine patients. Until now most investigations have focused on low back pain patients, even though pain drawings are used in neck pain patients as well. The aims of this study were to investigate the pain drawing and its association to preoperative demographics, psychological impairment, and pain intensity. METHODS: We carried out a post hoc analysis of a randomized controlled trial, comparing cervical disc replacement to fusion for radiculopathy related to degenerative disc disease...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28481126/increased-levels-of-alveolar-and-airway-exhaled-nitric-oxide-in-runners
#11
Alexandra Thornadtsson, Nikola Drca, Fabio Ricciardolo, Marieann Högman
AIM: The objective of this study was to apply extended NO analysis for measurements of NO dynamics in the lung, divided into alveolar and airway contribution, in amateur runners and marathoners. METHODS: The athletes participated in either a marathon or a half marathon. The athletes self-reported their age, weight, height, training distance per week, competing distance, cardio-pulmonary health, atopic status, and use of tobacco. Measurements of exhaled NO (FENO) with estimation of alveolar NO (CANO) and airway flux (JawNO), ventilation, pulse oximetry, and peak flow were performed before, immediately after, and 1 hour after completing the race...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28471260/exploring-men-s-pregnancy-planning-behaviour-and-fertility-knowledge-a-survey-among-fathers-in-sweden
#12
Maja Bodin, Lisa Käll, Tanja Tydén, Jenny Stern, Jennifer Drevin, Margareta Larsson
INTRODUCTION: Research about pregnancy-planning behaviour mostly focuses on women, even though pregnancy planning usually also concerns men. The purpose of this study was to investigate how men plan for family, and to measure their fertility knowledge after having become fathers. MATERIAL AND METHODS: Data were collected in 2014 as part of a Swedish longitudinal pregnancy-planning study. Men were recruited through their female partner one year after childbirth. Participants were asked to fill out a questionnaire about pregnancy planning, lifestyles, and fertility...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28436719/gambling-frequency-and-symptoms-of-attention-deficit-hyperactivity-disorder-in-relation-to-problem-gambling-among-swedish-adolescents-a-population-based-study
#13
Charlotta Hellström, Philippe Wagner, Kent W Nilsson, Jerzy Leppert, Cecilia Åslund
AIM: To investigate the associations between gambling frequency, attention-deficit hyperactivity disorder (ADHD) symptoms, and problem gambling among adolescent boys and girls. One hypothesis was that adolescents with increased ADHD symptoms have a higher frequency of gambling compared to adolescents with fewer ADHD symptoms. METHOD: A population-based sample of adolescents (aged 15-18 years) completed a questionnaire on demographics, gambling habits, ADHD symptoms, and problematic gambling; 1412 adolescents (from 4440 sampled) with gambling experience were included in the final sample...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28434271/minimizing-atelectasis-formation-during-general-anaesthesia-oxygen-washout-is-a-non-essential-supplement-to-peep
#14
Erland Östberg, Udo Auner, Mats Enlund, Henrik Zetterström, Lennart Edmark
BACKGROUND: Following preoxygenation and induction of anaesthesia, most patients develop atelectasis. We hypothesized that an immediate restoration to a low oxygen level in the alveoli would prevent atelectasis formation and improve oxygenation during the ensuing anaesthesia. METHODS: We randomly assigned 24 patients to either a control group (n = 12) or an intervention group (n = 12) receiving an oxygen washout procedure directly after intubation. Both groups were, depending on body mass index, ventilated with a positive end-expiratory pressure (PEEP) of 6-8 cmH2O during surgery...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28291376/cardioversion-of-atrial-fibrillation-does-not-affect-obstructive-sleep-apnea
#15
Niklas Höglund, Carin Sahlin, Milos Kesek, Steen M Jensen, Karl A Franklin
BACKGROUND: Sleep apnea is common in patients with atrial fibrillation, but the effect of the cardioversion of atrial fibrillation to sinus rhythm on central and obstructive apneas is mainly unknown. The primary aim of the study was to analyze the association between cardioversion of atrial fibrillation and sleep apneas, to investigate whether obstructive or central sleep apneas are reduced following cardioversion. A secondary objective was to study the effect on sleep quality. METHODS: Twenty-three patients with atrial fibrillation were investigated using overnight polysomnography, including esophagus pressure monitoring and ECG, before and after the cardioversion of persistent atrial fibrillation...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276782/respiratory-symptoms-and-lung-function-in-relation-to-wood-dust-and-monoterpene-exposure-in-the-wood-pellet-industry
#16
Håkan Löfstedt, Katja Hagström, Ing-Liss Bryngelsson, Mats Holmström, Anna Rask-Andersen
INTRODUCTION: Wood pellets are used as a source of renewable energy for heating purposes. Common exposures are wood dust and monoterpenes, which are known to be hazardous for the airways. The purpose of this study was to study the effect of occupational exposure on respiratory health in wood pellet workers. MATERIALS AND METHODS: Thirty-nine men working with wood pellet production at six plants were investigated with a questionnaire, medical examination, allergy screening, spirometry, and nasal peak expiratory flow (nasal PEF)...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276781/association-between-numbers-of-decayed-teeth-and-hba1c-in-japanese-patients-with-type-2-diabetes-mellitus
#17
Satoru Yonekura, Masato Usui, Shunichi Murano
BACKGROUND: Dental caries (DC) are more prevalent in individuals with diabetes than in healthy individuals. However, the association between glycaemic control and DC has not been well characterized in patients with type 2 diabetes mellitus (T2DM). We therefore assessed the association between glycated haemoglobin (HbA1c) serum concentrations and the prevalence of DC in patients with T2DM. METHODS: Retrospective analyses of data pertaining to 108 Japanese patients with T2DM hospitalized because of poor or worsened glycaemic control were included...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276780/utility-of-registries-for-post-marketing-evaluation-of-medicines-a-survey-of-swedish-health-care-quality-registries-from-a-regulatory-perspective
#18
Nils Feltelius, Rolf Gedeborg, Lennart Holm, Björn Zethelius
AIM: The aim of this study was to describe content and procedures in some selected Swedish health care quality registries (QRs) of relevance to regulatory decision-making. METHODS: A workshop was organized with participation of seven Swedish QRs which subsequently answered a questionnaire regarding registry content on drug treatments and outcomes. Patient populations, coverage, data handling and quality control, as well as legal and ethical aspects are presented...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28276779/development-of-new-levodopa-treatment-strategies-in-parkinson-s-disease-from-bedside-to-bench-to-bedside
#19
Sten-Magnus Aquilonius, Dag Nyholm
This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been developed in collaborative research within departments at Uppsala University. With this historical approach, reference priority is given to reports considered to be of special importance for this more than two decades long process 'from bedside to bench to bedside'...
June 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28256956/on-a-prolonged-interval-between-rectal-cancer-chemo-radiotherapy-and-surgery
#20
Bengt Glimelius
Preoperative radiotherapy (RT) or chemoradiotherapy (CRT) is often required before rectal cancer surgery to obtain low local recurrence rates or, in locally advanced tumours, to radically remove the tumour. RT/CRT in tumours responding completely can allow an organ-preserving strategy. The time from the end of the RT/CRT to surgery or to the decision not to operate has been prolonged during recent years. After a brief review of the literature, the relevance of the time interval to surgery is discussed depending upon the indication for RT/CRT...
March 2017: Upsala Journal of Medical Sciences
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