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Upsala Journal of Medical Sciences

Helge Rask-Andersen, Hao Li, Hubert Löwenheim, Marcus Müller, Kristian Pfaller, Annelies Schrott-Fischer, Rudolf Glueckert
BACKGROUND: Current attempts to regenerate cochlear sensorineural structures motivate further inspection of the human organ of hearing. Here, we analyzed the supernumerary inner hair cell (sIHC), a possible sign of regeneration and cell replacement. METHODS: Human cochleae were studied using field emission scanning electron microscopy (FESEM; maximum resolution 2 nm) obtained from individuals aged 44, 48, and 58 years with normal sensorineural pure-tone average (PTA) thresholds (PTA <20 dB)...
February 1, 2017: Upsala Journal of Medical Sciences
Lina Carlbom, José Caballero-Corbalán, Dan Granberg, Jens Sörensen, Barbro Eriksson, Håkan Ahlström
AIM: We wanted to explore if whole-body magnetic resonance imaging (MRI) including diffusion-weighted (DW) and liver-specific contrast agent-enhanced imaging could be valuable in lesion detection of neuroendocrine tumors (NET). [11C]-5-Hydroxytryptophan positron emission tomography/computed tomography (5-HTP PET/CT) was used for comparison. MATERIALS AND METHODS: Twenty-one patients with NET were investigated with whole-body MRI, including DW imaging (DWI) and contrast-enhanced imaging of the liver, and whole-body 5-HTP PET/CT...
November 29, 2016: Upsala Journal of Medical Sciences
Dora Ludviksdottir, Sigridur Th Valtysdottir, Hans Hedenström, Roger Hällgren, Björn Gudbjörnsson
OBJECTIVE: To evaluate in a longitudinal study the influence of airway hyperresponsiveness (AHR) on lung function in patients with primary Sjögren's syndrome (pSS). METHODS: Lung function was studied over an eight-year period in 15 patients who fulfilled the Copenhagen criteria for primary Sjögren's syndrome and who were covered in our earlier published study on AHR in patients with Sjögren's syndrome. Standard spirometry and measurements of lung volumes, diffusing capacity (DLCO), and AHR to methacholine were performed...
November 16, 2016: Upsala Journal of Medical Sciences
Mohammad Kharazmi, Håkan Scheer, Pär Hallberg
No abstract text is available yet for this article.
November 16, 2016: Upsala Journal of Medical Sciences
Outi Hovatta
No abstract text is available yet for this article.
October 19, 2016: Upsala Journal of Medical Sciences
Arne Andersson, Joey Lau Börjesson
No abstract text is available yet for this article.
October 18, 2016: Upsala Journal of Medical Sciences
Tobias Svensson, Kristina Lamberg Lundström, Martin Höglund, Honar Cherif
BACKGROUND: Patients treated for hematological malignancies have an increased risk of serious infections. Diagnosis and prompt initiation of therapy are essential. Bronchoalveolar lavage (BAL) is a well-established investigation for identifying the cause of pulmonary infiltrates in immunocompromised patients. The aim of the study was to determine the diagnostic yield of BAL in patients treated for hematological malignancies and how often it contributed to a modification of the anti-infectious therapy...
October 14, 2016: Upsala Journal of Medical Sciences
Maria E Stålhammar, Lena Douhan Håkansson, Anders Jonzon, Richard Sindelar
BACKGROUND: A prerequisite for an effective innate immunity is the migrative ability of neutrophils to respond to inflammatory and infectious agents such as the intermediate interleukin (IL)-8 and the end-target formyl-methionyl-leucyl-phenylalanine (fMLP) chemoattractants. The aim was to study the chemotactic capacity of neutrophils from newborn infants and adults in response to IL-8 and the bacterial peptide fMLP. METHODS: In the under-agarose cell migration assay, isolated leukocytes from healthy adults and from cord blood of healthy term newborn infants were studied with dose responses towards IL-8 and fMLP...
October 3, 2016: Upsala Journal of Medical Sciences
Sara Edsfeldt, Björn Holm, Margit Mahlapuu, Carol Reno, David A Hart, Monica Wiig
PURPOSE: To investigate the anti-adhesive mechanisms of PXL01 in sodium hyaluronate (HA) by using the rabbit lactoferrin peptide, rabPXL01 in HA, in a rabbit model of healing tendons and tendon sheaths. The mechanism of action for PXL01 in HA is interesting since a recent clinical study of the human lactoferrin peptide PXL01 in HA administered around repaired tendons in the hand showed improved digit mobility. MATERIALS AND METHODS: On days 1, 3, and 6 after tendon injury and surgical repair, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to assess mRNA expression levels for genes encoding the mucinous glycoprotein PRG4 (also called lubricin) and a subset of matrix proteins, cytokines, and growth factors involved in flexor tendon repair...
September 23, 2016: Upsala Journal of Medical Sciences
Maria Ekstrand Ragnar, Tanja Tydén, Ulrik Kihlbom, Margareta Larsson
INTRODUCTION: Genetic technologies advance rapidly. It is possible to undergo genetic carrier screening before pregnancy to examine genetic risks to future offspring. We aimed to investigate parents' interest and motives towards preconception genetic carrier screening (PCS) as well as factors associated with interest in PCS. MATERIAL AND METHODS: Our study sample consists of 777 parent couples within the longitudinal Swedish Pregnancy Planning study. Women responded to questionnaires at three occasions: in early pregnancy, late pregnancy, and one year after childbirth...
September 20, 2016: Upsala Journal of Medical Sciences
Obiamaka Ojukwu, Dilisha Patel, Judith Stephenson, Beth Howden, Jill Shawe
BACKGROUND: Preconception health and care aims to reduce parental risk factors before pregnancy through health promotion and intervention. Little is known about the preconception interventions that general practitioners (GPs) provide. The aim of this study was to examine GPs' knowledge, attitudes, and views towards preconception health and care in the general practice setting. METHODS: As part of a large mixed-methods study to explore preconception care in England, we surveyed 1,173 women attending maternity units and GP services in London and interviewed women and health professionals...
September 20, 2016: Upsala Journal of Medical Sciences
Tanja Tydén, Sarah Verbiest, Theo Van Achterberg, Margareta Larsson, Jenny Stern
Having children or not is one of the most important decisions that a person will make in his or her lifetime. The Reproductive Life Plan (RLP) is a protocol that aims to encourage both women and men to reflect on their reproductive intentions and to find strategies for successful family planning, for example to have the wanted number of children and to avoid unwanted pregnancies as well as ill-health that may threaten reproduction. The RLP was developed in an American context for promotion of reproductive health in a life cycle perspective...
September 20, 2016: Upsala Journal of Medical Sciences
Helena Kopp Kallner, Kristina Gemzell Danielsson
Preservation of fertility and optimizing health before pregnancy is becoming increasingly important in societies where childbirth often is postponed. Research shows that as women postpone childbirth they achieve higher levels of education and higher incomes. This leads to advantages for their children and for society. However, as women postpone childbearing they are at risk for contracting conditions which may affect fertility and/or pregnancies, pregnancy outcome, and the newborn child. Preconception counseling is therefore becoming increasingly important...
September 20, 2016: Upsala Journal of Medical Sciences
Sarah Verbiest, Erin McClain, Suzanne Woodward
In January 2015, the US Preconception Health and Health Care Initiative (PCHHC) established a new national vision that all women and men of reproductive age will achieve optimal health and wellness, fostering a healthy life course for them and any children they may have. Achieving this vision presents both challenges and opportunities. This manuscript describes the reasons why the US needs to prioritize preconception health as well as its efforts historically to advance change. The authors share lessons from past work and current strategies in the US to reach this ambitious goal...
September 20, 2016: Upsala Journal of Medical Sciences
Jacek Hochwälder, Agneta Bergsten Brucefors, Lena Hjelte
AIM: The CFQ-R is one of the most established disease-specific, health-related quality of life (HRQOL) measurements for patients with cystic fibrosis (CF). The aim was to evaluate the psychometric properties of the Swedish translation of CFQ-R in adults. METHOD: A total of 173 CF patients answered the CFQ-R. The CFQ-R was evaluated with regard to: (1) distributional properties; (2) reliability; and (3) construct validity. RESULTS: The majority of scales were negatively skewed with ceiling effects...
September 15, 2016: Upsala Journal of Medical Sciences
Helén Klint, Margareta H Lejonklou, Elina Karimullina, Monika Rönn, Lars Lind, P Monica Lind, Eva Brittebo
OBJECTIVES: Epidemiological studies report associations between exposure to the high-volume chemical and endocrine disruptor bisphenol A (BPA) and cardiovascular disorders, but there is a lack of experimental studies addressing the mechanisms of action of BPA on the cardiovascular system. In the present study, effects on markers for cardiovascular function of exposure to BPA and fructose in vivo in rat cardiac tissues, and of BPA exposure in human cardiomyocytes in vitro, were investigated...
September 13, 2016: Upsala Journal of Medical Sciences
Ilse Delbaere, Pascale Mokangi, Kristien Roelens, An De Sutter, Xavier Gellynck, Dimitri Beeckman, Liselot van de Walle, Pieter Vandenbulcke, Hans De Steur
INTRODUCTION: In February 2015, the Flemish Minister of Welfare, Public Health and Family launched a website on preconception care: ''. The website was developed in response to the lack of comprehensive communication on preconception care and the inadequate intake of folic acid among Flemish women. Despite the international recommendation to take 400 μg folic acid on a daily basis one month before conception until 12 weeks of pregnancy, studies show a lack of compliance in women wanting to become pregnant...
September 1, 2016: Upsala Journal of Medical Sciences
Wulf Becker, Anna Karin Lindroos, Cecilia Nälsén, Eva Warensjö Lemming, Veronica Öhrvik
BACKGROUND: Dietary intake and nutritional status are important for pregnancy and pregnancy outcomes. Dietary advice on folate, targeted to women of childbearing age, aims at preventing neural tube defects in the offspring. AIM: To describe food and nutrient intake and nutritional status among women of childbearing age in Sweden in relation to current nutrition recommendations. METHODS: Dietary intake was assessed using a web-based four-day consecutive food record among adults aged 18-80 years-'Riksmaten 2010-11 adults'...
August 25, 2016: Upsala Journal of Medical Sciences
Randi Sylvest, Jeanette Krogh Fürbringer, Lone Schmidt, Anja Pinborg
INTRODUCTION: Male infertility is potentially a severe, low-control stressor. There is limited knowledge of the expectations, needs, and assessment of fertility care among men with severe infertility. The aim of this study was to explore experience, expectations, needs, and assessment of fertility care among Danish men having severe male-factor infertility. METHODS: Semi-structured qualitative interview study with 10 men with very low sperm quality initiating intracytoplasmic sperm injection (ICSI) treatment at the Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark...
August 8, 2016: Upsala Journal of Medical Sciences
Tanja Tydén
No abstract text is available yet for this article.
August 3, 2016: Upsala Journal of Medical Sciences
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