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Nephron

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https://www.readbyqxmd.com/read/27889756/liquid-chromatography-mass-spectrometry-reveals-the-effect-of-lactobacillus-treatment-on-the-faecal-metabolite-profile-of-rats-with-chronic-renal-failure
#1
Bin Wu, Hongli Jiang, Quan He, Meng Wang, Jinhong Xue, Hua Liu, Kehui Shi, Meng Wei, Shanshan Liang, Liwen Zhang
BACKGROUND/AIM: Chronic kidney disease is accompanied by changes in the gut microbiome and by an increase in the number of gut pathogenic bacteria. The aim of this study was to investigate the difference of the faecal metabolic profiles in rats with uremia, and to determine whether the altered metabolites in the rats with uremia can be restored by Lactobacillus. METHODS: Thirty rats were randomly divided into 3 groups: sham, uremia and uremia + probiotic (UP) groups...
November 26, 2016: Nephron
https://www.readbyqxmd.com/read/27889755/prevalence-of-the-janus-kinase-2-v617f-mutation-in-patients-with-end-stage-renal-disease
#2
Axel Muendlein, Janine Ebner, Emanuel Zitt
No abstract text is available yet for this article.
November 26, 2016: Nephron
https://www.readbyqxmd.com/read/27842310/high-prevalence-of-diastolic-dysfunction-in-incident-patients-on-peritoneal-dialysis-association-with-low-thyroid-hormones
#3
Virginia Sánchez, Ramón Paniagua, Maria Del Carmen Prado, Carmen Mora, Oscar Orihuela, Francisco Martínez-Baca, Estela Elizabeth Pérez, Claudia Calzada, Renata Romero, Marcela Avila
BACKGROUND/AIMS: Diastolic dysfunction (DD) and low levels of thyroid hormones (TH) are frequent found in chronic kidney disease; both are associated with all-cause and cardiovascular mortality. However, a link between them has not yet been established. The aim of this study was to analyze DD as a surrogate marker of fibrosis and its association with TH in incident patients on peritoneal dialysis (PD). METHODS: A cross-sectional study with 183 incident patients on PD with preserved ejection fraction was performed...
November 15, 2016: Nephron
https://www.readbyqxmd.com/read/27820926/need-for-raising-awareness-monitoring-urinary-protein-excretion-in-cardiac-transplant-patients-receiving-mammalian-target-of-rapamycin-inhibitors
#4
Negiin Pourafshar, Ashkan Karimi, Jon Gregg, Amir Kazory
No abstract text is available yet for this article.
November 8, 2016: Nephron
https://www.readbyqxmd.com/read/27771693/kidney-injury-marker-1-and-neutrophil-gelatinase-associated-lipocalin-in-chronic-kidney-disease
#5
Esmeralda Castillo-Rodriguez, Raul Fernandez-Prado, Catalina Martin-Cleary, Maria Soledad Pizarro-Sánchez, Maria Dolores Sanchez-Niño, Ana Belen Sanz, Beatriz Fernandez-Fernandez, Alberto Ortiz
The current categorization of chronic kidney disease (CKD) is based on biomarkers of the glomerular function (estimated glomerular filtration rate, eGFR) and injury (urinary albumin creatinine ratio, UACR) and provides information on the risk of death and of progression of kidney disease. However, there are gaps in knowledge regarding the risk stratification of elderly patients with eGFR 45-60 ml/min/1.73 m2 and of younger patients with higher eGFR but physiological albuminuria. In this regard, most of the kidney cell mass is composed of tubules...
October 22, 2016: Nephron
https://www.readbyqxmd.com/read/27764832/attenuation-of-renal-functional-decline-following-angioplasty-and-stenting-in-atherosclerotic-renovascular-disease
#6
Rodrigo Hagemann, Vanessa Dos Santos Silva, Fábio Cardoso Carvalho, Pasqual Barretti, Luis Cuadrado Martin, Diana Vassallo, Philip A Kalra, Roberto Jorge da Silva Franco
BACKGROUND: To date, renal revascularization has not been shown to be advantageous when compared to optimized medical treatment in patients with atheromatous renovascular disease (ARVD). This study aims to investigate the effect of revascularization in patients with pre-intervention worsening renal function and in those with stable renal function. PATIENTS AND METHODS: In this single-centre observational study, patients who were diagnosed with at least 60% angiographic stenosis unilaterally or bilaterally between January 1996 and October 2008 and who were followed-up until February 2011 were retrospectively analysed...
October 21, 2016: Nephron
https://www.readbyqxmd.com/read/27764827/glomerular-filtration-rate-in-healthy-living-potential-kidney-donors-a-meta-analysis-supporting-the-construction-of-the-full-age-spectrum-equation
#7
Hans Pottel, Liesbeth Hoste, Eric Yayo, Pierre Delanaye
BACKGROUND: Normal kidney function or, more specifically, normal glomerular filtration rate (GFR) in men and women and its decline with age is still much debated today. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has gender (and race) multiplication factors, accounts for a decline that starts at very young age and assumes that the mean GFR is as high as 120-130 ml/min/1.73 m2 from a young age. The full age spectrum (FAS) estimated mean GFR is about 107 ml/min/1...
October 21, 2016: Nephron
https://www.readbyqxmd.com/read/27760424/renal-arterial-spin-labeling-magnetic-resonance-imaging
#8
Anton S Becker, Cristina Rossi
Arterial spin labeling (ASL) MRI allows the quantification of tissue perfusion without administration of exogenous contrast agents. Patients with reduced renal function or other contraindications to Gadolinium-based contrast media may benefit from the non-invasive monitoring of tissue microcirculation. So far, only few studies have investigated the sensitivity, the specificity and the reliability of the ASL techniques for the assessment of renal perfusion. Moreover, only little is known about the interplay between ASL markers of perfusion and functional renal filtration parameters...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27760420/risks-of-metformin-in-type-2-diabetes-and-chronic-kidney-disease-lessons-learned-from-taiwanese-data
#9
Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent for type 2 diabetes in the absence of contraindications. However, as metformin accumulation may lead to type B non-hypoxemic lactic acidosis, especially in the setting of kidney injury, chronic kidney disease, and overdose, regulatory agencies such as the United States Food and Drug Administration (FDA) have maintained certain restrictions regarding its use in kidney dysfunction...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27760419/relationship-between-anemia-and-serum-concentrations-of-calcium-and-phosphorus-in-advanced-non-dialysis-dependent-chronic-kidney-disease
#10
Mauro Boronat, Ángelo Santana, Elvira Bosch, Dionisio Lorenzo, Marta Riaño, César García-Cantón
BACKGROUND/AIMS: Different biochemical abnormalities of metabolic bone disease have been associated with anemia of chronic kidney disease (CKD), mainly in hemodialysis patients. However, all of these abnormalities are closely inter-related and their individual effect on the development of anemia is uncertain. This study was aimed to assess the relationship between anemia and a set of metabolic bone disease biomarkers in a cohort of adult patients with advanced non-dialysis-dependent CKD...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27701177/uremic-toxin-producing-gut-microbiota-in-rats-with-chronic-kidney-disease
#11
Mami Kikuchi, Mariko Ueno, Yoshiharu Itoh, Wataru Suda, Masahira Hattori
BACKGROUND: In patients with chronic kidney disease (CKD), many metabolites of gut microbiota retain in the body as uremic toxins (UTs). However, the kinds of bacteria producing UTs are rarely discussed. METHODS: We analyzed UT production and the composition of gut microbiota in CKD rats and cecectomized rats. AST-120, a spherical carbon adsorbent, was administrated to evaluate how the precursors of UT affect gut microbiota. Serum and urine levels of UTs were quantified by liquid chromatography/electrospray ionization-tandem mass spectrometry...
October 5, 2016: Nephron
https://www.readbyqxmd.com/read/27701176/the-protective-effect-of-febuxostat-on-chronic-tacrolimus-induced-nephrotoxicity-in-rats
#12
Hyun Seon Kim, Sun Woo Lim, Long Jin, Jian Jin, Byung Ha Chung, Chul Woo Yang
BACKGROUND: The use of calcineurin inhibitors is a well-known risk factor for hyperuricemia in kidney transplant recipients. We evaluated the effect of febuxostat (Fx), a new uric acid-lowering drug, on hyperuricemia and renal injury in an experimental model of chronic tacrolimus (Tac)-induced nephropathy. METHODS: Chronic Tac nephropathy was induced by administering Tac (1.5 mg/kg/day) to rats on a low-salt diet (0.05%) with oxonic acid (OA, 2%, 0.2 g/kg/day) for 28 days...
October 5, 2016: Nephron
https://www.readbyqxmd.com/read/27701157/truncating-wilms-tumor-suppressor-gene-1-mutation-in-an-xx-female-with-adult-onset-focal-segmental-glomerulosclerosis-and-streak-ovaries-a-case-report
#13
Julia Hoefele, Markus J Kemper, Ulf Schoenermarck, Susanna Mueller, Hanns-Georg Klein, Anja Lemke
About 30% of children with nephrotic syndrome (NS) have inherited forms. Among them, mutations in Wilms tumor suppressor gene 1 (WT1) are a well characterized cause associated with steroid-resistant NS, Wilms tumor, and urogenital malformation in males. However, the role of WT1 mutations in adult-onset focal segmental glomerulosclerosis (FSGS) is unclear. We report the case of a 38-year-old female with FSGS. She had been diagnosed with streak ovaries during diagnostic workup for infertility. Mutational analysis identified the heterozygous mutation c...
October 5, 2016: Nephron
https://www.readbyqxmd.com/read/27694745/emergence-of-dipstick-proteinuria-predicts-overt-nephropathy-in-patients-following-stem-cell-transplantation
#14
Kumiko Momoki, Tsukasa Yamaguchi, Kazuteru Ohashi, Minoru Ando, Kosaku Nitta
BACKGROUND: Stem cell transplantation (SCT) places a heavy burden on the kidneys, often resulting in renal dysfunction or nephrotic syndrome. This study attempted to show that early-onset proteinuria predicts the development of overt nephropathy. METHODS: A total of 831 patients who received allogeneic SCT were surveyed. Excluding those with prior kidney disease and those lacking in an observation period ≥1 year after SCT, 251 patients were eligible for the study...
October 1, 2016: Nephron
https://www.readbyqxmd.com/read/27676651/rituximab-in-membranous-nephropathy-not-all-studies-are-created-equal
#15
Paolo Cravedi
Many prospective studies and a recent randomized controlled trial have shown that the B-cell-depleting monoclonal antibody, rituximab, safely promotes the remission of nephrotic syndrome in approximately 65% of patients with membranous nephropathy (MN). Mechanistic studies have indicated that rituximab-induced proteinuria reduction is associated with clearance of anti-podocyte antigens phospholipase 2 receptor autoantibodies and subepithelial immune complexes, the hallmarks of the disease. A recently published study reported results which, at first sight, looked less favorable and implied that, due to a publication bias against negative results, the efficacy of rituximab in MN might be overestimated...
September 28, 2016: Nephron
https://www.readbyqxmd.com/read/27669572/venous-thromboembolism-in-primary-nephrotic-syndrome-is-the-risk-high-enough-to-justify-prophylactic-anticoagulation
#16
Alastair J Rankin, Emily P McQuarrie, Jonathan G Fox, Colin C Geddes, Bruce MacKinnon
BACKGROUND: The reported incidence of venous thromboembolism (VTE) in patients with nephrotic syndrome (NS) varies widely, as does the approach to prophylactic anticoagulation. We aimed to assess the incidence of VTE in patients with primary NS in order to inform a sample size calculation to determine if a future clinical trial will ever be feasible. METHODS: All adults undergoing native renal biopsy for NS between 2008 and 2013 yielding a diagnosis of primary glomerulonephritis were identified...
September 24, 2016: Nephron
https://www.readbyqxmd.com/read/27665619/expression-of-cyt-c-mediated-mitochondrial-apoptosis-related-proteins-in-rat-renal-proximal-tubules-during-development
#17
Xiao-Feng Song, He Tian, Ping Zhang, Zhen-Xing Zhang
BACKGROUND: Apoptosis regulates embryogenesis, organ metamorphosis and tissue homeostasis. Mitochondrial signaling is an apoptotic pathway, in which Cyt-c and Apaf-1 are transformed into an apoptosome, which activates procaspase-9 and triggers apoptosis. This study evaluated Cyt-c, Apaf-1 and caspase-9 expression during renal development. METHODS: Kidneys from embryonic (E) 16-, 18-, and 20-day-old fetuses and postnatal (P) 1-, 3-, 5-, 7-, 14-, and 21-day-old pups were obtained...
September 24, 2016: Nephron
https://www.readbyqxmd.com/read/27655253/major-depression-and-long-term-outcomes-of-acute-kidney-injury
#18
Rasheed A Balogun, Bolanle A Omotoso, Wenjun Xin, Jennie Z Ma, Kenneth W Scully, Fatiu A Arogundade, Emaad M Abdel-Rahman
BACKGROUND: The prevalence of depression and its relationship to poor outcomes in chronic kidney disease are established facts. Such prognostic impact in acute kidney injury (AKI) is not known. This study determines the prognostic implication of a diagnosis of depression on renal recovery and major adverse cardiovascular events (MACE), a new diagnosis of myocardial infarction, cerebrovascular disease (CVD, stroke or transient ischemic attack) or congestive heart failure (CHF) after hospitalization with AKI...
September 22, 2016: Nephron
https://www.readbyqxmd.com/read/27643796/should-we-still-believe-in-randomized-controlled-trials-in-nephrology
#19
Monica Cortinovis, Norberto Perico, Giuseppe Remuzzi
The randomized controlled trial (RCT) is the cornerstone upon which clinical decision-making is based. Pivotal RCTs in the nephrology area efficiently demonstrated the renoprotective effects of treatment with renin-angiotensin system inhibitors in patients with diabetic and non-diabetic proteinuric nephropathies. However, there is concern about the increasing cost, complexity and duration of clinical studies. Moreover, recent large RCTs addressing key issues for patients with renal disease failed to achieve definitive conclusions mainly due to critical flaws in the investigational strategies, including the adoption of excessive/fixed doses of the study medications, inappropriate use of the placebo-controlled design, enrollment of low-risk individuals, poor reporting of adverse events or unreliable evaluation of renal function...
September 20, 2016: Nephron
https://www.readbyqxmd.com/read/27597998/changing-paradigms-in-acute-kidney-injury-from-mechanisms-to-management
#20
Ravindra L Mehta, Kelly K Andringa, Paul W Sanders, Anupam Agarwal
No abstract text is available yet for this article.
September 7, 2016: Nephron
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