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Nephron

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https://www.readbyqxmd.com/read/28064277/smad2-phosphorylation-in-diabetic-kidney-tubule-epithelial-cells-is-associated-with-modulation-of-several-transforming-growth-factor-%C3%AE-family-members
#1
Lise Høj Thomsen, Morten Fog-Tonnesen, Lisbeth Nielsen Fink, Jenny Norlin, Amaya García de Vinuesa, Troels Krarup Hansen, Emile de Heer, Peter Ten Dijke, Alexander Rosendahl
BACKGROUND: The role of transforming growth factor-β (TGF-β) has recently gained much attention in diabetic nephropathy and kidney fibrosis. In this study, we extend this to an assessment of transcriptional regulation of the entire TGF-β superfamily in kidneys from diabetic vs. healthy mice. In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-β/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients...
January 7, 2017: Nephron
https://www.readbyqxmd.com/read/28052302/rationale-for-the-evaluation-of-renal-functional-reserve-in-living-kidney-donors-and-recipients-a-pilot-study
#2
Alessandra Spinelli, Aashish Sharma, Gianluca Villa, Sara Samoni, Francesco Ramponi, Alessandra Brocca, Alessandra Brendolan, Stefano Chiaramonte, Giuseppe Castellano, Loreto Gesualdo, Claudio Ronco
BACKGROUND: In living kidney transplantation, preoperative donors' renal functional reserve (RFR) may correlate with postoperative residual renal function in both donors and recipients. The aim of this study was to evaluate the donors' RFR before transplantation and to compare basal and stress renal function before and after transplantation in both donors and recipients. METHODS: Seven pairs of living kidney donors and recipients were considered for this observational study...
January 5, 2017: Nephron
https://www.readbyqxmd.com/read/28030868/implementation-of-an-automated-primary-care-acute-kidney-injury-warning-system-a-quantitative-and-qualitative-review-of-2-years-of-experience
#3
Omid Sadeghi Alavijeh, Jas Bansal, Katie Hadfield, Christopher Laing, Anne Dawnay
BACKGROUND: Acute kidney injury (AKI) is often detected late, leading to worse clinical outcomes. In 2012, we pioneered an AKI-alerting system for primary care clinicians (PCCs). We retrospectively analysed the alerts and evaluated PCC satisfaction to assess the feasibility of the system. METHODS: The study used a 2-pronged approach. AKI alerts, generated by an algorithm designed by University College London Hospital biochemistry department between June 2012 and June 2014, were analysed to reveal the demographics and outcomes of each patient generating an alert...
December 29, 2016: Nephron
https://www.readbyqxmd.com/read/28030861/the-use-of-automated-electronic-alerts-in-studying-short-term-outcomes-associated-with-community-acquired-acute-kidney-injury
#4
Adil M Hazara, Musab Elgaali, Sarah Naudeer, Stephen Holding, Sunil Bhandari
BACKGROUND/AIMS: The use of electronic alerts (e-alerts) may increase the detection rate of acute kidney injury (AKI) since they are sensitive to small changes in serum creatinine. Our aim was to follow-up a cohort of patients presenting to hospital from the community with AKI (community-acquired AKI [c-AKI]), detected through the use of e-alerts, and describe their short-term outcomes regardless of whether they were subsequently admitted to hospital. METHODS: Blood samples for all hospital attenders from the community either to the Accidents and Emergency department or one of the acute care areas of the hospital during a 6-month period (November 1, 2013-April 30, 2014) were screened for presence of c-AKI using a locally developed e-alerts system based on Kidney Disease: Improving Global Outcomes criteria...
December 29, 2016: Nephron
https://www.readbyqxmd.com/read/28013303/the-impact-of-peroxisome-proliferator-activated-receptor-gamma-and-its-interaction-with-abdominal-obesity-on-diabetic-nephropathy-in-chinese-han
#5
Meihong Zhang, Hongying Yuan, Changsheng Li, Chunling Li
BACKGROUND: Several studies have focused on the association between peroxisome proliferators-activated receptor gamma (PPARG) polymorphism and diabetic nephropathy (DN); however, the results of these studies were inconsistent, and until now, no population-based study has focused on the impact of PPARG gene-abdominal obesity interaction on DN risk. The aim of this study was to investigate the impact of PPARG polymorphisms and its interaction with abdominal obesity on DN risk in the Chinese Han population...
December 24, 2016: Nephron
https://www.readbyqxmd.com/read/27992875/calf-resistivity-values-in-chronic-kidney-disease-in-a-caucasian-population
#6
Eric Seibert, Stephan G Müller, Johanna Pattmöller, Peter Kotanko, Fansan Zhu, Nathan W Levin, Roman Fiedler, Martin K Kuhlmann, Matthias Girndt
BACKGROUND: Continuous intradialytic calf bioimpedance spectroscopy (cBIS) allows assessment of changes in calf extracellular fluid volume (ECV) to determine dry weight (DW) in hemodialysis patients. During dialysis, calf ECV decreases until excessive ECV has been removed and normalized resistivity ρN,5 rises to values comparable to those of a normal population (cBIS-DW). It is not clear whether chronic kidney disease (CKD) itself influences ρN,5 and whether normal values depend on race and ethnicity...
December 20, 2016: Nephron
https://www.readbyqxmd.com/read/27978521/the-hyperfiltering-kidney-in-diabetes
#7
Roberto Trevisan, Alessandro Roberto Dodesini
Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic renal disease. Although the mechanism of hyperfiltration is still unclear, there is mounting evidence that the increased reabsorption of glucose and sodium by sodium glucose transporter-2 (SGLT-2) is involved in this altered renal function. There is a possibility that SGLT-2 inhibition may correct hyperfiltration in diabetes, adding a new therapeutic approach to halt renal disease in patients with diabetes...
December 16, 2016: Nephron
https://www.readbyqxmd.com/read/27978513/an-overview-of-errors-and-flaws-of-estimated-gfr-versus-true-gfr-in-patients-with-diabetes-mellitus
#8
Sergio Luis-Lima, Esteban Porrini
The determination of renal function is crucial in patients with type 2 diabetes (T2DM), a population at risk for chronic kidney disease (CKD). Glomerular filtration rate (GFR) can be measured (mGFR) with gold standard methods or estimated (eGFR) with formulas. Since 1957, when Effersoe published the first formula, more than 50 equations have been developed to estimate GFR. In this review, we examined the studies that compared mGFR and eGFR in patients with T2DM to analyze the performance of those formulae in this population...
December 16, 2016: Nephron
https://www.readbyqxmd.com/read/27974720/anemia-and-long-term-renal-prognosis-in-patients-with-post-renal-acute-kidney-injury-of-nonmalignant-cause
#9
Sho Sasaki, Hiroo Kawarazaki, Takeshi Hasegawa, Hideaki Shima, Toshihide Naganuma, Yugo Shibagaki
BACKGROUND/AIMS: The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS: We performed a multicenter retrospective cohort study. Consecutive adult patients from December 2006 to February 2010, who met the requirements as mentioned in the definition of PoR-AKI, were included. Patients without data on baseline renal function and at 6 months after PoR-AKI were excluded...
December 15, 2016: Nephron
https://www.readbyqxmd.com/read/27974710/clinical-predictors-of-response-to-prednisone-plus-cyclophosphamide-in-patients-with-idiopathic-membranous-nephropathy
#10
Shu Li, Ling Wang, Minfang Zhang, Wenyan Zhou, Wei Fang, Qin Wang, Chaojun Qi, Shan Mou, Xinghua Shao, Zhaohui Ni
BACKGROUND: Complete remission (CR) and partial remission (PR) are beneficial to the long-term outcome of patients with idiopathic membranous nephropathy (iMN). However, we are lacking in studies that evaluate the clinical predictors of response to treatment with prednisone plus cyclophosphamide (CP). The objectives of the study are to identify clinical factors that could predict clinical remission or relapse in patients with iMN who were treated with prednisone plus i.v. CP therapy. METHODS: This retrospective study recruited a total of 102 eligible patients diagnosed with biopsy-proven iMN between January 2010 and December 2013 in our center...
December 15, 2016: Nephron
https://www.readbyqxmd.com/read/27960172/effect-of-ast-120-in-chronic-kidney-disease-treatment-still-a-controversy
#11
Junna Yamaguchi, Tetsuhiro Tanaka, Reiko Inagi
AST-120 (kremezin; Kureha Chemical, Tokyo, Japan) is an oral spherical carbonaceous adsorbent, which was approved for clinical use in Japanese chronic kidney disease (CKD) patients in 1991. It adsorbs indole, the precursor of indoxyl sulfate, in the intestines and prevents indoxyl sulfate production. Indoxyl sulfate, initially identified as a major uremic toxin that causes uremic symptoms, contributes to CKD progression. Since AST-120 decreases serum indoxyl sulfate in a dose-dependent manner, multicenter prospective trials have been conducted in Japan in the 1980s; these trials were mostly in favor of the efficacy of AST-120 in delaying the initiation of dialysis in patients with advanced stage CKD...
December 14, 2016: Nephron
https://www.readbyqxmd.com/read/27951537/association-between-obstructive-sleep-apnea-and-acute-kidney-injury-in-critically-ill-patients-a-propensity-matched-study
#12
Lin Dou, Haitao Lan, Daniel J Reynolds, Tina M Gunderson, Rahul Kashyap, Ognjen Gajic, Sean Caples, Guangxi Li, Kianoush B Kashani
BACKGROUND/AIMS: Obstructive sleep apnea (OSA) is a known risk factor for chronic kidney disease (CKD); however, its association with acute kidney injury (AKI) is not well documented. We aimed to study whether OSA is associated with the risk of AKI in the intensive care unit (ICU) setting. METHODS: All consecutive adult Olmsted County, MN residents who were admitted in Mayo Clinic ICUs from January 1, 2010 to December 31, 2010 were screened. Chronic and acute risk factors were collected within the first 48 h of ICU admission...
December 13, 2016: Nephron
https://www.readbyqxmd.com/read/27951533/correlations-of-plasma-desphosphorylated-uncarboxylated-matrix-gla-protein-with-vascular-calcification-and-vascular-stiffness-in-chronic-kidney-disease
#13
Sipanan Thamratnopkoon, Paweena Susantitaphong, Monravee Tumkosit, Pisut Katavetin, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Somchai Eiam-Ong
BACKGROUND: Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification and needs vitamin K-dependent carboxylation for its activity. High levels of desphosphorylated uncarboxylated MGP (dp-ucMGP) were significantly associated with vitamin K deficiency and vascular calcification. This study was conducted to explore the correlations of plasma dp-ucMGP with vascular calcification and vascular stiffness in chronic kidney disease (CKD) patients. METHODS: This cross-sectional study enrolled 83 CKD stages 3-5 patients...
December 13, 2016: Nephron
https://www.readbyqxmd.com/read/27941331/interleukin-17ra-promotes-humoral-responses-and-glomerular-injury-in-experimental-rapidly-progressive-glomerulonephritis
#14
Joanna R Ghali, Kim M O'Sullivan, Peter J Eggenhuizen, Stephen R Holdsworth, A Richard Kitching
BACKGROUND/AIMS: Interleukin (IL)-17A and IL-17F are proinflammatory cytokines, which signal through a receptor complex consisting of IL-17RA and IL-17RC subunits. We sought to define the role of IL-17RA expression by leukocytes and stromal cells in nephritogenic immunity and injury in experimental glomerulonephritis. METHODS: Glomerulonephritis was induced in wild-type and IL-17RA-deficient (IL-17RA-/-) mice by sheep anti-mouse glomerular basement membrane globulin...
December 10, 2016: Nephron
https://www.readbyqxmd.com/read/27941326/conversion-from-brand-name-neoral-to-the-generic-ciqorin-in-stable-renal-transplant-recipients
#15
Monica Cortinovis, Eliana Gotti, Matias Trillini, Fabiola Carrara, Flavio Gaspari, Piero Ruggenenti, Giuseppe Remuzzi, Norberto Perico
BACKGROUND/AIMS: Transplant physicians and patients are often reluctant to change to generic versions of immunosuppressive drugs with a narrow therapeutic index, such as ciclosporin (CsA). Thus, in routine follow-up for kidney transplant patients receiving CsA maintenance immunosuppressive therapy in our center, we evaluated the exchangeability of the brand name, Neoral, and the recently approved CsA generic formulation, Ciqorin. METHODS: We assessed the complete 12-h CsA pharmacokinetic profile and direct measurement of glomerular filtration rate (mGFR) of 10 patients receiving stable doses of Neoral (138 ± 43 mg/day), at least 6 months after kidney transplantation (Neoral 1)...
December 10, 2016: Nephron
https://www.readbyqxmd.com/read/27889756/liquid-chromatography-mass-spectrometry-reveals-the-effect-of-lactobacillus-treatment-on-the-faecal-metabolite-profile-of-rats-with-chronic-renal-failure
#16
Bin Wu, Hongli Jiang, Quan He, Meng Wang, Jinhong Xue, Hua Liu, Kehui Shi, Meng Wei, Shanshan Liang, Liwen Zhang
BACKGROUND/AIM: Chronic kidney disease is accompanied by changes in the gut microbiome and by an increase in the number of gut pathogenic bacteria. The aim of this study was to investigate the difference of the faecal metabolic profiles in rats with uremia, and to determine whether the altered metabolites in the rats with uremia can be restored by Lactobacillus. METHODS: Thirty rats were randomly divided into 3 groups: sham, uremia and uremia + probiotic (UP) groups...
November 26, 2016: Nephron
https://www.readbyqxmd.com/read/27889755/prevalence-of-the-janus-kinase-2-v617f-mutation-in-patients-with-end-stage-renal-disease
#17
Axel Muendlein, Janine Ebner, Emanuel Zitt
No abstract text is available yet for this article.
November 26, 2016: Nephron
https://www.readbyqxmd.com/read/27842310/high-prevalence-of-diastolic-dysfunction-in-incident-patients-on-peritoneal-dialysis-association-with-low-thyroid-hormones
#18
Virginia Sánchez, Ramón Paniagua, Maria Del Carmen Prado, Carmen Mora, Oscar Orihuela, Francisco Martínez-Baca, Estela Elizabeth Pérez, Claudia Calzada, Renata Romero, Marcela Avila
BACKGROUND/AIMS: Diastolic dysfunction (DD) and low levels of thyroid hormones (TH) are frequent found in chronic kidney disease; both are associated with all-cause and cardiovascular mortality. However, a link between them has not yet been established. The aim of this study was to analyze DD as a surrogate marker of fibrosis and its association with TH in incident patients on peritoneal dialysis (PD). METHODS: A cross-sectional study with 183 incident patients on PD with preserved ejection fraction was performed...
November 15, 2016: Nephron
https://www.readbyqxmd.com/read/27820926/need-for-raising-awareness-monitoring-urinary-protein-excretion-in-cardiac-transplant-patients-receiving-mammalian-target-of-rapamycin-inhibitors
#19
Negiin Pourafshar, Ashkan Karimi, Jon Gregg, Amir Kazory
No abstract text is available yet for this article.
November 8, 2016: Nephron
https://www.readbyqxmd.com/read/27771693/kidney-injury-marker-1-and-neutrophil-gelatinase-associated-lipocalin-in-chronic-kidney-disease
#20
Esmeralda Castillo-Rodriguez, Raul Fernandez-Prado, Catalina Martin-Cleary, Maria Soledad Pizarro-Sánchez, Maria Dolores Sanchez-Niño, Ana Belen Sanz, Beatriz Fernandez-Fernandez, Alberto Ortiz
The current categorization of chronic kidney disease (CKD) is based on biomarkers of the glomerular function (estimated glomerular filtration rate, eGFR) and injury (urinary albumin creatinine ratio, UACR) and provides information on the risk of death and of progression of kidney disease. However, there are gaps in knowledge regarding the risk stratification of elderly patients with eGFR 45-60 ml/min/1.73 m2 and of younger patients with higher eGFR but physiological albuminuria. In this regard, most of the kidney cell mass is composed of tubules...
October 22, 2016: Nephron
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