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Gioacchino Li Cavoli, Rosanna Turdo, Tancredi Vincenzo Li Cavoli
No abstract text is available yet for this article.
November 9, 2018: Nephron
Sung Yoon Lim, Kyu-Beck Lee, Hyang Kim, Young Youl Hyun
BACKGROUND: Previous cross-sectional studies have shown that low muscle mass is associated with albuminuria in the general population. However, the longitudinal association of low muscle mass with the development of albuminuria is not well known at this time. METHODS: We evaluated 48,101 individuals without chronic kidney disease (CKD) who underwent 2 health check-ups in 2012 and 2016. Participants' skeletal muscle masses were measured using a bioelectrical impedance analyzer and compared via a skeletal muscle mass index (SMI; SMI [%] = total skeletal muscle mass [kg]/body weight [kg] × 100)...
November 9, 2018: Nephron
Mohamed Shantier, William P Martin, Rajneet Singh, Paul McDermott, Rory Gallen, Sami Suleiman, Donal N Reddan, Louise Giblin, David Lappin, Yvonne M O'Meara, Matthew D Griffin
BACKGROUND/AIMS: Three-day-a-week chronic haemodialysis (cHD) involves 1 long (72 h) and 2 short (48 h) inter-dialytic periods (IDPs). We aimed to determine whether BP control following the long IDP is inferior to the short IDPs. METHODS: All pre- and post-dialysis BP and weight measurements over a 4-week period were retrospectively analyzed among 135 clinically stable cHD patients at 2 academic centres with comparisons between measurements recorded following short and long IDPs...
November 9, 2018: Nephron
Rajkumar Chinnadurai, Constantina Chrysochou, Philip A Kalra
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is recognised to be a strong risk factor for causing cardiovascular disease (CVD) and chronic kidney disease (CKD), independent of the presence of diabetes mellitus. The association of NAFLD with outcomes in patients with diabetic kidney disease (DKD) has been variably reported. This study aimed to investigate the association of NAFLD with cardiovascular, renal outcomes and mortality in patients with advanced DKD (CKD 3-5, not on dialysis)...
November 1, 2018: Nephron
Namiko A Goto, Ismay N van Loon, Moira I Morpey, Marianne C Verhaar, Hanna C Willems, Mariëlle H Emmelot-Vonk, Michiel L Bots, Franciscus T J Boereboom, Marije E Hamaker
BACKGROUND/AIMS: Decision-making in elderly patients considering dialysis is highly complex. With the increasing number of elderly with end-stage kidney disease (ESKD), it may be important to assess geriatric impairments in this population. The aim of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study was to assess the prevalence of geriatric impairments and frailty in the elderly ESKD population by means of a geriatric assessment (GA), which is a comprehensive tool for overall health assessment...
November 1, 2018: Nephron
Maria Florencia Martínez, Luis Daniel Mazzuoccolo, Elisabet Mónica Oddo, Paula Virginia Iscoff, Carolina Muchnik, Hartmut P H Neumann, Rodolfo Santiago Martin, Adriana Raquel Fraga, Pablo Javier Azurmendi
The calcium signalling and hedgehog (HH) signalling pathways operate in the primary cilium. Abnormalities in these pathways cause autosomal dominant polycystic kidney disease (ADPKD) and naevoid basal cell carcinoma syndrome (NBCCS) respectively. Several reports have proposed that hyperactivation of the HH pathway in animal models of polycystic kidney disease affects normal renal development and renal cyst phenotype. A family with 2 cases (a proband and her sister) of ADPKD and NBCCS coinheritance led us to investigate whether interactions may be present in the 2 pathways...
October 26, 2018: Nephron
Pulkit Chaudhury, Sherif Armanyous, Serge C Harb, Laura Ferreira Provenzano, Tarek Ashour, Stacey E Jolly, Susana Arrigain, Victoria Konig, Jesse D Schold, Sankar D Navaneethan, Joseph V Nally, Georges N Nakhoul
BACKGROUND/AIMS: contrast-induced nephropathy (CIN) is well described following an administration of intraarterial contrast, but its occurrence after intravenous (IV) contrast is being questioned. We evaluated the incidence of acute kidney injury (AKI), post-contrast AKI (PC-AKI), CIN, dialysis and mortality in patients with chronic kidney disease (CKD) undergoing non-contrast computed tomography (NCCT) or contrast CT (CCT) or coronary angiography (CoA). METHODS: We identified individuals who had CoA or CCT or NCCT between 2010 and 2015 in the Cleveland Clinic CKD registry...
October 26, 2018: Nephron
Ahmed Fayed, Mahmoud M El Nokeety, Tarek Samy Abdelaziz, Hussien H Samir, Wael M Hamza, Tarek El Shabony
INTRODUCTION: The side effects profile of the new direct--acting antivirals for the treatment of hepatitis C virus (HCV) is not fully elucidated. OBJECTIVE: In this cross-sectional study, we aim to describe the incidence and characteristics of a novel observation of de novo renal cryoglobulinemic glomerulonephritis after successful treatment with DAA. METHODOLOGY: A total of 12,985 Hepatitis C Patients (genotype IV) received the new DAA. After successful treatment, patients with deranged renal functions or proteinuria were referred to the nephrology department for assessment...
October 25, 2018: Nephron
Carsten Bergmann
Early and severe forms of polycystic kidney disease (PKD) do already manifest during childhood or adolescence. They are characterized by enlarged kidneys and diminished renal function that prenatally may result in Potter's oligohydramnios sequence. Genetically, various defects can mimic this phenotype. Most common are PKHD1 mutations that lead to autosomal recessive PKD (ARPKD). About the same number of children do carry mutations in the dominant autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and less frequent PKD2, often arise de novo or may affect both disease alleles in a recessive mode...
October 25, 2018: Nephron
Liane Correia-Costa, Ana Azevedo, Alberto Caldas Afonso
Obesity is known to be associated with a myriad of cardiovascular and metabolic comorbidities. In children, several longitudinal studies have shown that obesity consequences start early in life and accompany the obese child into adulthood, implying a higher risk of adverse cardiovascular events. More recently, data related to the possible role of obesity in the risk of kidney disease in adults, independently of diabetes, has started to become more available. In children, the evidence is scarcer, but it has also been acknowledged that obesity acts as a risk factor for disease progression when kidney impairment already exists, thereby increasing the risk of death among children with end-stage renal disease (ESRD)...
October 25, 2018: Nephron
Alastair Hutchison, Andrew Whelton, Ravi Thadhani, Heinrich Achenbach, Andrea Vergani, Jingyang Wu, Gillian Hall
BACKGROUND/AIMS: This post-marketing observational study assessed the long-term safety of lanthanum carbonate (LaC) in US patients with end-stage renal disease (NCT00567723). METHODS: Patients (≥18 years old) undergoing dialysis, who had Medicare as their primary healthcare payer, and records in the United States Renal Data System were followed-up for 5 years. Patients who had received LaC for at least 12 consecutive weeks formed the exposed cohort. During the same time period, patients who had undergone dialysis for at least 12 consecutive weeks and had been treated with any other phosphate binder formed the primary comparator cohort...
October 23, 2018: Nephron
Kunitoshi Iseki, Lisa L Henn, Takanobu Nomura, Eiichiro Kanda, Kazuhiko Tsuruya, Hideki Hirakata, Friedrich K Port, Ronald L Pisoni, Francesca Tentori, Bruce M Robinson
BACKGROUND: Abnormal chronic kidney disease-mineral and bone disorder (CKD-MBD) markers have been associated with adverse outcomes in hemodialysis (HD) patients. Dialysate calcium concentration (D-Ca) likely influences serum calcium and phosphorus levels. Optimal D-Ca level remains unclear. We hypothesized that higher D-Ca is associated with cardiovascular events and mortality among Japanese HD patients. METHODS: Enrollment data of chronic HD patients in the prospective observational study JDOPPS, phases 1-5 (1999-2015), provided exposures and covariates...
October 19, 2018: Nephron
Paloma Cañete, Andrés Fernández, Ana Solís, Jimena Del Castillo, Sarah Fernández, Jesús López-Herce
BACKGROUND/AIMS: The incidence of acute kidney injury (AKI) after cardiac arrest (CA) in adults is associated with a high mortality, but there are few data about the incidence and prognosis of AKI after CA in children. The aim of our study was to analyze the incidence of AKI in children who have experienced an in-hospital CA and its association with mortality. METHODS: A retrospective observational study in a prospective database was performed including children between the ages 1 month and 16 years, who had undergone an in-hospital CA...
October 19, 2018: Nephron
Bogusz Trojanowicz, Thomas Imdahl, Christof Ulrich, Roman Fiedler, Matthias Girndt
BACKGROUND: Decreased levels of leucocytic angiotensin converting enzyme 2 (ACE2) relate to atherosclerosis in patients with chronic kidney disease (CKD). Recently, micro RNA 421 (miR-421) was found to target and down-regulate ACE2 in human cardiac myofibroblasts. In this study, we investigated the correlation between serum levels of miR-421 and ACE2 transcripts in circulating leukocytes of healthy individuals (NP), CKD (3-5) and haemodialysis (HD) patients. Furthermore, we tested the possible interaction between miR-421 and 3'-UTR of ACE2 under normal and uremic milieu...
October 16, 2018: Nephron
Rosa E Pérez-Morales, María Dolores Del Pino, José Manuel Valdivielso, Alberto Ortiz, Carmen Mora-Fernández, Juan F Navarro-González
BACKGROUND: Diabetes is a growing public health problem. Diabetic kidney disease (DKD) is the most prevalent chronic renal disease and the major cause of end-stage renal failure worldwide, predominantly due to the increase of Type 2 diabetes associated with obesity. The intimate mechanisms leading to the development and progression of renal injury in DKD are not well understood, but current knowledge indicates that its pathogenesis is multifactorial, where the immune response and inflammation appear to be relevant factors...
October 1, 2018: Nephron
Georgia E Fouli, Luigi Gnudi
Diabetic nephropathy is the commonest cause of end-stage renal disease and affects between 30 and 45% of patients with diabetes mellitus. There is no cure for diabetic nephropathy and the current management of this condition includes glycaemic control, blockade of the renin-angiotensin aldosterone system and lifestyle changes. However, many patients eventually progress to end-stage renal disease. The exact pathogenesis of diabetic nephropathy is still being researched, and recent advances have led to the development of several novel potential therapeutic targets...
September 26, 2018: Nephron
Anna Levin, Deepika Nair, Abdul Rashid Qureshi, Peter Bárány, Olof Heimburger, Björn Anderstam, Peter Stenvinkel, Annette Bruchfeld, Johanna S Ungerstedt
BACKGROUND: Inflammation and oxidative stress play important roles in the pathogenesis and progression of chronic kidney disease (CKD) and in its complications, in particular cardiovascular disease, a major cause of death among patients undergoing dialysis treatment. We recently described that Glutaredoxin1 (Grx), an intracellular antioxidant, catalyzes oxidoreductase reactions also extracellularly, and that serum Grx levels correlate to disease severity in type 2 diabetes. AIM: In the current study we assess Grx as a potential clinical marker of oxidative stress in CKD...
September 25, 2018: Nephron
Mohammad Reza Khatami, Arash Jalali, Elmira Zare, Saeid Sadeghian
BACKGROUND/AIMS: Renal artery stenosis (RAS) is a known cause of secondary hypertension and renal failure. Although renal artery angiography is the gold standard for diagnosing RAS, a simple method to estimate if patients will develop RAS is required. The aim of this retrospective study was to develop a simple risk score to predict significant RAS. METHODS: Four thousand one hundred seventy-seven patients who underwent renal angiography between 2002 and 2016 at Tehran Heart Center were included...
September 25, 2018: Nephron
Manohar Bairy, Faith H W See, Ru Sin Lim
BACKGROUND: Estimating the glomerular filtration rate (eGFR) when the creatinine (Cr) is rapidly changing, as in acute kidney injury (AKI), has been a challenge. The Kinetic Estimated Glomerular Filtration Rate (KeGFR) formula by S. Chen estimates the GFR in the acute state by factoring the time interval between rising Cr values and the volume of distribution (VD). It provides the clinician with an eGFR value for each non-steady state Cr value. We applied the KeGFR formula to detect AKI in an adult non-ICU inpatient setting...
September 19, 2018: Nephron
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April 12, 2018: Nephron
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