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Environmental Health Perspectives

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https://www.readbyqxmd.com/read/30398377/signaling-events-downstream-of-ahr-activation-that-contribute-to-toxic-responses-the-functional-role-of-an-ahr-dependent-long-noncoding-rna-slincr-using-the-zebrafish-model
#1
Gloria R Garcia, Prarthana Shankar, Cheryl L Dunham, Abraham Garcia, Jane K La Du, Lisa Truong, Susan C Tilton, Robert L Tanguay
BACKGROUND: A structurally diverse group of chemicals, including dioxins [e.g., 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)] and polycyclic aromatic hydrocarbons (PAHs), can xenobiotically activate the aryl hydrocarbon receptor (AHR) and contribute to adverse health effects in humans and wildlife. In the zebrafish model, repression of sox9b has a causal role in several AHR-mediated toxic responses, including craniofacial cartilage malformations; however, the mechanism of sox9b repression remains unknown...
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30387366/evaluation-of-bisphenol-a-bpa-exposures-on-prostate-stem-cell-homeostasis-and-prostate-cancer-risk-in-the-nctr-sprague-dawley-rat-an-niehs-fda-clarity-bpa-consortium-study
#2
Gail S Prins, Wen-Yang Hu, Lishi Xie, Guang-Bin Shi, Dan-Ping Hu, Lynn Birch, Maarten C Bosland
BACKGROUND: Previous work determined that early life exposure to low-dose Bisphenol A (BPA) increased rat prostate cancer risk with aging. Herein, we report on prostate-specific results from CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity), which aims to resolve uncertainties regarding BPA toxicity. OBJECTIVES: We sought to a) reassess whether a range of BPA exposures drives prostate pathology and/or alters prostatic susceptibility to hormonal carcinogenesis, and b) test whether chronic low-dose BPA targets prostate epithelial stem and progenitor cells...
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30407086/a-state-of-the-science-review-of-mercury-biomarkers-in-human-populations-worldwide-between-2000-and-2018
#3
Niladri Basu, Milena Horvat, David C Evers, Irina Zastenskaya, Pál Weihe, Joanna Tempowski
BACKGROUND: The Minamata Convention on Mercury provided a mandate for action against global mercury pollution. However, our knowledge of mercury exposures is limited because there are many regions and subpopulations with little or no data. OBJECTIVE: We aimed to increase worldwide understanding of human exposures to mercury by collecting, collating, and analyzing mercury concentrations in biomarker samples reported in the published scientific literature. METHOD: A systematic search of the peer-reviewed scientific literature was performed using three databases...
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392403/estimates-of-the-global-burden-of-ambient-formula-see-text-ozone-and-formula-see-text-on-asthma-incidence-and-emergency-room-visits
#4
Susan C Anenberg, Daven K Henze, Veronica Tinney, Patrick L Kinney, William Raich, Neal Fann, Chris S Malley, Henry Roman, Lok Lamsal, Bryan Duncan, Randall V Martin, Aaron van Donkelaar, Michael Brauer, Ruth Doherty, Jan Eiof Jonson, Yanko Davila, Kengo Sudo, Johan C I Kuylenstierna
BACKGROUND: Asthma is the most prevalent chronic respiratory disease worldwide, affecting 358 million people in 2015. Ambient air pollution exacerbates asthma among populations around the world and may also contribute to new-onset asthma. OBJECTIVES: We aimed to estimate the number of asthma emergency room visits and new onset asthma cases globally attributable to fine particulate matter ([Formula: see text]), ozone, and nitrogen dioxide ([Formula: see text]) concentrations...
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392401/longitudinal-analysis-of-long-term-air-pollution-levels-and-blood-pressure-a-cautionary-tale-from-the-multi-ethnic-study-of-atherosclerosis
#5
Sara D Adar, Yeh-Hsin Chen, Jennifer C D'Souza, Marie S O'Neill, Adam A Szpiro, Amy H Auchincloss, Sung Kyun Park, Martha L Daviglus, Ana V Diez Roux, Joel D Kaufman
BACKGROUND: Air pollution exposures are hypothesized to impact blood pressure, yet few longitudinal studies exist, their findings are inconsistent, and different adjustments have been made for potentially distinct confounding by calendar time and age. OBJECTIVE: We aimed to investigate the associations of long- and short-term [Formula: see text] and [Formula: see text] concentrations with systolic and diastolic blood pressures and incident hypertension while also accounting for potential confounding by age and time...
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392399/community-water-fluoridation-and-urinary-fluoride-concentrations-in-a-national-sample-of-pregnant-women-in-canada
#6
Christine Till, Rivka Green, John G Grundy, Richard Hornung, Raichel Neufeld, E Angeles Martinez-Mier, Pierre Ayotte, Gina Muckle, Bruce Lanphear
BACKGROUND: Fluoride exposures have not been established for pregnant women who live in regions with and without community water fluoridation. OBJECTIVE: Our aim was to measure urinary fluoride levels during pregnancy. We also assessed the contribution of drinking-water and tea consumption habits to maternal urinary fluoride (MUF) concentrations and evaluated the impact of various dilution correction standards, including adjustment for urinary creatinine and specific gravity (SG)...
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392397/software-tools-to-facilitate-systematic-review-used-for-cancer-hazard-identification
#7
Andrew J Shapiro, Sébastien Antoni, Kathryn Z Guyton, Ruth M Lunn, Dana Loomis, Ivan Rusyn, Gloria D Jahnke, Pamela J Schwingl, Suril S Mehta, Josh Addington, Neela Guha
Objective and systematic methods to search, review, and synthesize published studies are a fundamental aspect of carcinogen hazard classification. Systematic review is a historical strength of the International Agency for Research on Cancer (IARC) Monographs Program and the United States National Toxicology Program (NTP) Office of the Report on Carcinogens (RoC). Both organizations are tasked with evaluating peer-reviewed, published evidence to determine whether specific substances, exposure scenarios, or mixtures pose a cancer hazard to humans...
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392395/erratum-down-to-earth-the-emerging-field-of-planetary-health
#8
Nate Seltenrich
No abstract text is available yet for this article.
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392394/long-term-exposure-to-ambient-fine-particulate-matter-and-chronic-kidney-disease-a-cohort-study
#9
Ta-Chien Chan, Zilong Zhang, Bo-Cheng Lin, Changqing Lin, Han-Bing Deng, Yuan Chieh Chuang, Jimmy W M Chan, Wun Kai Jiang, Tony Tam, Ly-Yun Chang, Gerard Hoek, Alexis K H Lau, Xiang Qian Lao
BACKGROUND: Chronic kidney disease (CKD) is a serious global public health challenge, but there is limited information on the connection between air pollution and risk of CKD. OBJECTIVE: The aim of this study was to investigate the association between long-term exposure to particulate matter (PM) with an aerodynamic diameter of less than [Formula: see text] ([Formula: see text]) and the development of CKD in a large cohort. METHODS: A total of 100,629 nonCKD Taiwanese residents age 20 y or above were included in this study between 2001 and 2014...
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392389/safe-from-the-storm-creating-climate-resilient-health-care-facilities
#10
Nate Seltenrich
No abstract text is available yet for this article.
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30272490/drilling-into-critical-windows-of-exposure-trimester-specific-associations-between-gas-development-and-preterm-birth
#11
Lindsey Konkel
No abstract text is available yet for this article.
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30272489/prelude-to-disease-formula-see-text-and-markers-of-diabetes-risk-in-nondiabetic-adults
#12
Silke Schmidt
No abstract text is available yet for this article.
October 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30392381/erratum-evaluation-of-a-physiologically-based-pharmacokinetic-pbpk-model-for-inorganic-arsenic-exposure-using-data-from-two-diverse-human-populations
#13
Hisham A El-Masri, Tao Hong, Cara Henning, William Mendez, Edward E Hudgens, David J Thomas, Janice S Lee
No abstract text is available yet for this article.
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30256157/infant-dietary-exposures-to-environmental-chemicals-and-infant-child-health-a-critical-assessment-of-the-literature
#14
Judy S LaKind, Geniece M Lehmann, Matthew H Davis, Erin P Hines, Satori A Marchitti, Cecilia Alcala, Matthew Lorber
BACKGROUND: The benefits of breastfeeding to the infant and mother have been well documented. It is also well known that breast milk contains environmental chemicals, and numerous epidemiological studies have explored relationships between background levels of chemicals in breast milk and health outcomes in infants and children. OBJECTIVES: In this paper, we examine epidemiological literature to address the following question: Are infant exposures to background levels of environmental chemicals in breast milk and formula associated with adverse health effects? We critically review this literature a) to explore whether exposure-outcome associations are observed across studies, and b) to assess the literature quality...
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30256156/more-cases-of-hand-foot-and-mouth-disease-in-china-a-consequence-of-climate-change
#15
Charles W Schmidt
No abstract text is available yet for this article.
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30256155/pesticide-use-and-incident-hypothyroidism-in-pesticide-applicators-in-the-agricultural-health-study
#16
Srishti Shrestha, Christine G Parks, Whitney S Goldner, Freya Kamel, David M Umbach, Mary H Ward, Catherine C Lerro, Stella Koutros, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler
BACKGROUND: Though evidence suggests that some pesticides may have thyroid-disrupting properties, prospective studies of associations between specific pesticides and incident thyroid disease are limited. OBJECTIVE: We evaluated associations between use of specific pesticides and incident hypothyroidism in private pesticide applicators in the Agricultural Health Study (AHS). METHODS: Self-reported incident hypothyroidism ([Formula: see text] cases) was studied in relation to ever-use and intensity-weighted cumulative days of pesticide use at study enrollment...
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30256154/a-global-level-model-of-the-potential-impacts-of-climate-change-on-child-stunting-via-income-and-food-price-in-2030
#17
Simon J Lloyd, Mook Bangalore, Zaid Chalabi, R Sari Kovats, Stèphane Hallegatte, Julie Rozenberg, Hugo Valin, Petr Havlík
BACKGROUND: In 2016, 23% of children (155 million) aged [Formula: see text] were stunted. Global-level modeling has consistently found climate change impacts on food production are likely to impair progress on reducing undernutrition. OBJECTIVES: We adopt a new perspective, assessing how climate change may affect child stunting via its impacts on two interacting socioeconomic drivers: incomes of the poorest 20% of populations (due to climate impacts on crop production, health, labor productivity, and disasters) and food prices...
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30230350/uncomfortable-uncertainty-do-otc-analgesics-disrupt-fetal-germ-cell-development
#18
Lindsey Konkel
No abstract text is available yet for this article.
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30226399/residential-proximity-to-major-roadways-at-birth-dna-methylation-at-birth-and-midchildhood-and-childhood-cognitive-test-scores-project-viva-massachusetts-usa
#19
Cheng Peng, Martijn den Dekker, Andres Cardenas, Sheryl L Rifas-Shiman, Heike Gibson, Golareh Agha, Maria H Harris, Brent A Coull, Joel Schwartz, Augusto A Litonjua, Dawn L DeMeo, Marie-France Hivert, Matthew W Gilman, Sharon K Sagiv, Yvonne de Kluizenaar, Janine F Felix, Vincent W Jaddoe, Emily Oken, Liesbeth Duijts, Diane R Gold, Andrea A Baccarelli
BACKGROUND: Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health. OBJECTIVE: We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes. METHODS: We estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother-child pairs in Project Viva...
September 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30212226/effects-of-the-endocrine-disrupting-chemicals-vinclozolin-and-polychlorinated-biphenyls-on-physiological-and-sociosexual-phenotypes-in-f2-generation-sprague-dawley-rats
#20
Krittika Krishnan, Nitish Mittal, Lindsay M Thompson, Mariana Rodriguez-Santiago, Christine L Duvauchelle, David Crews, Andrea C Gore
BACKGROUND: Exposure to endocrine-disrupting chemicals (EDCs) during gestation influences development of the F1 generation offspring and can result in disease and dysfunction in adulthood. Limited evidence suggests consequences on the F2 generation, exposed as germ cells within the F1 fetus. These F2s provide a unique window into the programming effects of EDCs. OBJECTIVE: This study assessed intergenerational effects of EDC exposure on adult physiology and behavior in Sprague-Dawley rats...
September 2018: Environmental Health Perspectives
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