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Environmental Health Perspectives

Carmen de Keijzer, Cathryn Tonne, Xavier Basagaña, Antònia Valentín, Archana Singh-Manoux, Jordi Alonso, Josep Maria Antó, Mark J Nieuwenhuijsen, Jordi Sunyer, Payam Dadvand
BACKGROUND: Evidence on beneficial associations of green space with cognitive function in older adults is very scarce and mainly limited to cross-sectional studies. OBJECTIVES: We aimed to investigate the association between long-term residential surrounding greenness and cognitive decline. METHODS: This longitudinal study was based on three waves of data from the Whitehall II cohort, providing a 10-y follow-up (1997-1999 to 2007-2009) of 6,506 participants (45-68 y old) from the United Kingdom...
July 2018: Environmental Health Perspectives
Pierre Martin, Claire Bladier, Bette Meek, Olivier Bruyere, Eve Feinblatt, Mathilde Touvier, Laurence Watier, David Makowski
BACKGROUND: Transparency when documenting and assessing weight of evidence (WOE) has been an area of increasing focus for national and international health agencies. OBJECTIVE: The objective of this work was to conduct a critical review of WOE analysis methods as a basis for developing a practical framework for considering and assessing WOE in hazard identification in areas of application at the French Agency for Food, Environmental and Occupational Health and Safety (ANSES)...
July 2018: Environmental Health Perspectives
Hisham A El-Masri, Tao Hong, Cara Henning, William Mendez, Edward E Hudgens, David J Thomas, Janice S Lee
BACKGROUND: Multiple epidemiological studies exist for some of the well-studied health endpoints associated with inorganic arsenic (iAs) exposure; however, results are usually expressed in terms of different exposure/dose metrics. Physiologically based pharmacokinetic (PBPK) models may be used to obtain a common exposure metric for application in dose-response meta-analysis. OBJECTIVE: A previously published PBPK model for inorganic arsenic (iAs) was evaluated using data sets for arsenic-exposed populations from Bangladesh and the United States...
July 2018: Environmental Health Perspectives
Oliver Robinson, Ibon Tamayo, Montserrat de Castro, Antonia Valentin, Lise Giorgis-Allemand, Norun Hjertager Krog, Gunn Marit Aasvang, Albert Ambros, Ferran Ballester, Pippa Bird, Leda Chatzi, Marta Cirach, Audrius Dėdelė, David Donaire-Gonzalez, Regina Gražuleviciene, Minas Iakovidis, Jesus Ibarluzea, Mariza Kampouri, Johanna Lepeule, Léa Maitre, Rosie McEachan, Bente Oftedal, Valerie Siroux, Remy Slama, Euripides G Stephanou, Jordi Sunyer, Jose Urquiza, Kjell Vegard Weyde, John Wright, Martine Vrijheid, Mark Nieuwenhuijsen, Xavier Basagaña
BACKGROUND: The urban exposome is the set of environmental factors that are experienced in the outdoor urban environment and that may influence child development. OBJECTIVE: The authors' goal was to describe the urban exposome among European pregnant women and understand its socioeconomic determinants. METHODS: Using geographic information systems, remote sensing and spatio-temporal modeling we estimated exposure during pregnancy to 28 environmental indicators in almost 30,000 women from six population-based birth cohorts, in nine urban areas from across Europe...
July 2018: Environmental Health Perspectives
Kristianna G Pettibone, David M Balshaw, Caroline Dilworth, Christina H Drew, Janet E Hall, Michelle Heacock, Alfonso R Latoni, Kimberly A McAllister, Liam R O'Fallon, Claudia Thompson, Nigel J Walker, Mary S Wolfe, Demia S Wright, Gwen W Collman
The National Institute of Environmental Health Sciences (NIEHS) introduces a new translational research framework that builds upon previous biomedical models to create a more comprehensive and integrated environmental health paradigm. The framework was developed as a graphical construct that illustrates the complexity of designing, implementing, and tracking translational research in environmental health. We conceptualize translational research as a series of concentric rings and nodes, defining "translation" as movement either from one ring to another or between nodes on a ring...
July 2018: Environmental Health Perspectives
Iain R Lake, Natalia R Jones, Maureen Agnew, Clare M Goodess, Filippo Giorgi, Lynda Hamaoui-Laguel, Mikhail A Semenov, Fabien Solmon, Jonathan Storkey, Robert Vautard, Michelle M Epstein
[This corrects the article DOI: 10.1289/EHP173.].
July 2018: Environmental Health Perspectives
Nate Seltenrich
No abstract text is available yet for this article.
July 2018: Environmental Health Perspectives
Cecile Karrer, Thomas Roiss, Natalie von Goetz, Darja Gramec Skledar, Lucija Peterlin Mašič, Konrad Hungerbühler
BACKGROUND: The endocrine disrupting chemical bisphenol A (BPA) has been facing stricter regulations in recent years. BPA analogs, such as the bisphenols S, F, and AF (BPS, BPF, and BPAF) are increasingly used as replacement chemicals, although they were found to exert estrogenic effects similar to those of BPA. Research has shown that only the parent compounds have affinity to the estrogen receptors, suggesting that the pharmacokinetic behavior of bisphenols (BPs) can influence their potency...
July 2018: Environmental Health Perspectives
Sharon K Sagiv, Maria H Harris, Robert B Gunier, Katherine R Kogut, Kim G Harley, Julianna Deardorff, Asa Bradman, Nina Holland, Brenda Eskenazi
[This corrects the article DOI: 10.1289/EHP2580.].
July 2018: Environmental Health Perspectives
Michele Balik-Meisner, Lisa Truong, Elizabeth H Scholl, Jane K La Du, Robert L Tanguay, David M Reif
BACKGROUND: Modern societies are exposed to vast numbers of potentially hazardous chemicals. Despite demonstrated linkages between chemical exposure and severe health effects, there are limited, often conflicting, data on how adverse health effects of exposure differ across individuals. OBJECTIVES: We tested the hypothesis that population variability in response to certain chemicals could elucidate a role for gene-environment interactions (GxE) in differential susceptibility...
June 2018: Environmental Health Perspectives
Weihsueh A Chiu, Daniel A Axelrad, Chimeddulam Dalaijamts, Chris Dockins, Kan Shao, Andrew J Shapiro, Greg Paoli
BACKGROUND: The National Academies recommended risk assessments redefine the traditional noncancer Reference Dose (RfD) as a probabilistically derived risk-specific dose, a framework for which was recently developed by the World Health Organization (WHO). OBJECTIVES: Our aim was to assess the feasibility and implications of replacing traditional RfDs with probabilistic estimates of the human dose associated with an effect magnitude M and population incidence I (HDM I)...
June 2018: Environmental Health Perspectives
Yutaka Aoki, Debra J Brody
BACKGROUND: The CDC recommends a targeted strategy for childhood blood lead screening based on participation in federal programs, such as Medicaid and the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Yet, there is scarcity of data on blood lead levels (BLLs) among WIC participants. OBJECTIVE: Our objective was to investigate whether children participating in WIC and not enrolled in Medicaid, who have not been targeted in the historical Medicaid-focused screening strategy, have higher BLLs than children in neither of these programs...
June 2018: Environmental Health Perspectives
Genevieve S Silva, Joshua L Warren, Nicole C Deziel
BACKGROUND: Hydraulically fractured wells produce 2-14 million liters of wastewater, which may contain toxic and radioactive compounds. The wastewater is predominantly disposed of using Class II injection wells. OBJECTIVE: Our objective was to evaluate the relationship between sociodemographic characteristics and injection well locations in Ohio. METHODS: Using state and federal data sources, we classified Ohio census block groups by presence of injection wells, number of hydraulically fractured wells, sociodemographic factors (median household income, % white, population density, % education, median age, voter turnout), and geographic information (land area, water area, situated over shale)...
June 2018: Environmental Health Perspectives
John E French, Daniel M Gatti, Daniel L Morgan, Grace E Kissling, Keith R Shockley, Gabriel A Knudsen, Kim G Shepard, Herman C Price, Deborah King, Kristine L Witt, Lars C Pedersen, Steven C Munger, Karen L Svenson, Gary A Churchill
[This corrects the article DOI:].
June 2018: Environmental Health Perspectives
Céline Lukowicz, Sandrine Ellero-Simatos, Marion Régnier, Arnaud Polizzi, Frédéric Lasserre, Alexandra Montagner, Yannick Lippi, Emilien L Jamin, Jean-François Martin, Claire Naylies, Cécile Canlet, Laurent Debrauwer, Justine Bertrand-Michel, Talal Al Saati, Vassilia Théodorou, Nicolas Loiseau, Laïla Mselli-Lakhal, Hervé Guillou, Laurence Gamet-Payrastre
BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. OBJECTIVES: We aimed to evaluate, in mice, the metabolic consequences of chronic dietary exposure to a pesticide mixture at nontoxic doses, relevant to consumers' risk assessment...
June 2018: Environmental Health Perspectives
David Mills, Russell Jones, Cameron Wobus, Julia Ekstrom, Lesley Jantarasami, Alexis St Juliana, Allison Crimmins
[This corrects the article DOI:].
June 2018: Environmental Health Perspectives
Linda S Birnbaum
No abstract text is available yet for this article.
June 2018: Environmental Health Perspectives
William A Suk, Michelle L Heacock, Brittany A Trottier, Sara M Amolegbe, Maureen D Avakian, Heather F Henry, Danielle J Carlin, Larry G Reed
BACKGROUND: The National Institute of Environmental Health Sciences (NIEHS) Superfund Basic Research and Training Program (SRP) funds a wide range of transdisciplinary research projects spanning the biomedical and environmental sciences and engineering, supporting and promoting the application of that research to solving real-world problems. OBJECTIVES: We used a case study approach to identify the economic and societal benefits of SRP-funded research, focusing on the use of potentially hazardous substance remediation and site monitoring tools...
June 2018: Environmental Health Perspectives
Jennifer L Guelfo, Thomas Marlow, David M Klein, David A Savitz, Scott Frickel, Michelle Crimi, Eric M Suuberg
BACKGROUND: Multiple Northeast U.S. communities have discovered per- and polyfluoroalkyl substances (PFASs) in drinking water aquifers in excess of health-based regulatory levels or advisories. Regional stakeholders (consultants, regulators, and others) need technical background and tools to mitigate risks associated with exposure to PFAS-affected groundwater. OBJECTIVES: The aim was to identify challenges faced by stakeholders to extend best practices to other regions experiencing PFAS releases and to establish a framework for research strategies and best management practices...
June 2018: Environmental Health Perspectives
Jonathan Huang, Brenda Eskenazi, Riana Bornman, Stephen Rauch, Jonathan Chevrier
BACKGROUND: Indoor residual spraying (IRS) of insecticides, conducted in low- and middle-income countries to control malaria, may result in high exposure to dichlorodiphenyltrichloroethane (DDT), its breakdown product dichlorodiphenyldichloroethylene (DDE), or pyrethroids. Animal studies suggest in utero exposure to these chemicals may increase childhood infection frequency. OBJECTIVES: We investigated associations between maternal DDT/E and pyrethroid metabolite concentration and child infection associations in an IRS setting in which susceptibility factors are common and infections are leading causes of child morbidity and mortality...
June 2018: Environmental Health Perspectives
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