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Environmental Health Perspectives

Nuria Matilla-Santander, Damaskini Valvi, Maria-Jose Lopez-Espinosa, Cyntia B Manzano-Salgado, Ferran Ballester, Jesús Ibarluzea, Loreto Santa-Marina, Thomas Schettgen, Mònica Guxens, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility. OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter)...
November 13, 2017: Environmental Health Perspectives
Helena Skröder, Maria Kippler, Fahmida Tofail, Marie Vahter
BACKGROUND: In older adults, selenium status has been positively associated with cognitive function. We recently reported a positive association between maternal selenium status in pregnancy and children's cognitive function at 1.5 y. OBJECTIVE: We followed up the children to assess if prenatal and childhood selenium status was associated with cognitive abilities at 5 and 10 y. METHODS: This longitudinal cohort study was nested in Maternal and Infant Nutrition Interventions in Matlab (MINIMat), a population-based, randomized supplementation trial in pregnancy in rural Bangladesh...
November 7, 2017: Environmental Health Perspectives
Peng Yin, Michael Brauer, Aaron Cohen, Richard T Burnett, Jiangmei Liu, Yunning Liu, Ruiming Liang, Weihua Wang, Jinlei Qi, Lijun Wang, Maigeng Zhou
BACKGROUND: Cohort studies in North America and western Europe have reported increased risk of mortality associated with long-term exposure to fine particles (PM2.5), but to date, no such studies have been reported in China, where higher levels of exposure are experienced. OBJECTIVES: We estimated the association between long-term exposure to PM2.5 with nonaccidental and cause-specific mortality in a cohort of Chinese men. METHODS: We conducted a prospective cohort study of 189,793 men 40 y old or older during 1990-91 from 45 areas in China...
November 7, 2017: Environmental Health Perspectives
Nate Seltenrich
No abstract text is available yet for this article.
November 6, 2017: Environmental Health Perspectives
Shira Joudan, Leo W Y Yeung, Scott A Mabury
BACKGROUND: Perfluoroalkyl phosphinic acids (PFPiAs) have been detected in humans, wildlife, and various environmental matrices. These compounds have been used with perfluoroalkyl phosphonic acids (PFPAs) as surfactants in consumer products and as nonfoaming additives in pesticide formulations. Unlike the structurally related perfluoroalkyl sulfonic and carboxylic acids, little is known about the biological fate of PFPiAs. OBJECTIVES: We determined the biotransformation products of PFPiAs and some pharmacokinetic parameters in a rat model...
November 3, 2017: Environmental Health Perspectives
Nancy Averett
No abstract text is available yet for this article.
November 2, 2017: Environmental Health Perspectives
Nate Seltenrich
No abstract text is available yet for this article.
November 1, 2017: Environmental Health Perspectives
Courtney C Carignan, Lidia Mínguez-Alarcón, Craig M Butt, Paige L Williams, John D Meeker, Heather M Stapleton, Thomas L Toth, Jennifer B Ford, Russ Hauser
[This corrects the article DOI: 10.1289/EHP1021.].
November 1, 2017: Environmental Health Perspectives
Jennifer J Adibi, Yaqi Zhao, Lei V Zhan, Mirhan Kapidzic, Nicholas Larocque, Hannu Koistinen, Ilpo T Huhtaniemi, Ulf-Håkan Stenman
BACKGROUND: Observational studies have reported associations between maternal phthalate levels and adverse outcomes at birth and in the health of the child. Effects on placental function have been suggested as a biologic basis for these findings. OBJECTIVE: We evaluated the effects of phthalates on placental function in vitro by measuring relevant candidate genes and proteins. MATERIALS AND METHODS: Human trophoblast progenitor cells were isolated at 7-14 wk of pregnancy (two female and three male concepti), and villous cytotrophoblast cells (vCTBs) were isolated at 15-20 wk (three female and four male concepti)...
October 31, 2017: Environmental Health Perspectives
Carol Potera
No abstract text is available yet for this article.
October 30, 2017: Environmental Health Perspectives
Ben Armstrong, Michelle L Bell, Micheline de Sousa Zanotti Stagliorio Coelho, Yue-Liang Leon Guo, Yuming Guo, Patrick Goodman, Masahiro Hashizume, Yasushi Honda, Ho Kim, Eric Lavigne, Paola Michelozzi, Paulo Hilario Nascimento Saldiva, Joel Schwartz, Matteo Scortichini, Francesco Sera, Aurelio Tobias, Shilu Tong, Chang-Fu Wu, Antonella Zanobetti, Ariana Zeka, Antonio Gasparrini
BACKGROUND: In many places, daily mortality has been shown to increase after days with particularly high or low temperatures, but such daily time-series studies cannot identify whether such increases reflect substantial life shortening or short-term displacement of deaths (harvesting). OBJECTIVES: To clarify this issue, we estimated the association between annual mortality and annual summaries of heat and cold in 278 locations from 12 countries. METHODS: Indices of annual heat and cold were used as predictors in regressions of annual mortality in each location, allowing for trends over time and clustering of annual count anomalies by country and pooling estimates using meta-regression...
October 27, 2017: Environmental Health Perspectives
Joseph Y Abrams, Rodney J Weber, Mitchel Klein, Stefanie E Samat, Howard H Chang, Matthew J Strickland, Vishal Verma, Ting Fang, Josephine T Bates, James A Mulholland, Armistead G Russell, Paige E Tolbert
BACKGROUND: Oxidative potential (OP) has been proposed as a measure of toxicity of ambient particulate matter (PM). OBJECTIVES: Our goal was to address an important research gap by using daily OP measurements to conduct population-level analysis of the health effects of measured ambient OP. METHODS: A semi-automated dithiothreitol (DTT) analytical system was used to measure daily average OP (OPDTT) in water-soluble fine PM at a central monitor site in Atlanta, Georgia, over eight sampling periods (a total of 196 d) during June 2012-April 2013...
October 26, 2017: Environmental Health Perspectives
Margaret A Handley, Kali Nelson, Eric Sanford, Cassidy Clarity, Sophia Emmons-Bell, Anuhandra Gorukanti, Patrick Kennelly
In California, the annual number of children under age 6 y of age with blood lead levels (BLL) ≥10μg/dL is estimated at over 1,000 cases, and up to 10,000 cases when BLL between 4.5 and 9.5 μg/dL are included. State-issued health alerts for food contamination provide one strategy for tracking sources of food-related lead exposures. As well, California passed legislation in 2006 for the Food and Drug Branch (FDB) of the state health department to test and identify lead in candy. This report presents health alert data from California over a 14-y period, compares data before and after the candy testing program began, and examines country of origin, ZIP code data, and time from candy testing to release of health alerts for lead-contaminated candies for 2011-2012...
October 26, 2017: Environmental Health Perspectives
Charles W Schmidt
No abstract text is available yet for this article.
October 24, 2017: Environmental Health Perspectives
Scott M Bartell
Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that has been detected in >100 public water systems in the United States alone. A variety of epidemiological investigations of PFOA have been published, mostly using measured or modeled serum PFOA concentrations as the exposure metric. Comparison of drinking water PFOA concentrations to those study findings or to typical serum concentrations requires pharmacokinetic modeling. This brief communication describes an online Javascript calculator that easily plots the expected serum PFOA concentration over time and at steady state for adults after starting or stopping consumption of PFOA-contaminated water...
October 24, 2017: Environmental Health Perspectives
Fabiana Manservisi, Clara Babot Marquillas, Annalisa Buscaroli, James Huff, Michelina Lauriola, Daniele Mandrioli, Marco Manservigi, Simona Panzacchi, Ellen K Silbergeld, Fiorella Belpoggi
[This corrects the article DOI: 10.1289/EHP419.].
October 23, 2017: Environmental Health Perspectives
Julia R Barrett
No abstract text is available yet for this article.
October 23, 2017: Environmental Health Perspectives
Carrie Arnold
No abstract text is available yet for this article.
October 20, 2017: Environmental Health Perspectives
Yu Yuan, Yang Xiao, Wei Feng, Yiyi Liu, Yanqiu Yu, Lue Zhou, Gaokun Qiu, Hao Wang, Bing Liu, Kang Liu, Handong Yang, Xiulou Li, Xinwen Min, Ce Zhang, Chengwei Xu, Xiaomin Zhang, Meian He, Frank B Hu, An Pan, Tangchun Wu
BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD. METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex...
October 19, 2017: Environmental Health Perspectives
Julia R Barrett
No abstract text is available yet for this article.
October 17, 2017: Environmental Health Perspectives
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