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Environmental Health Perspectives

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https://www.readbyqxmd.com/read/27814246/serum-metabolomic-profiles-in-neonatal-mice-following-oral-brominated-flame-retardant-exposures-to-hexabromocyclododecane-hbcd-alpha-gamma-and-commercial-mixture
#1
David T Szabo, Wimal Pathmasiri, Susan Sumner, Linda S Birnbaum
BACKGROUND: Hexabromocyclododecane (HBCD) is a high production volume brominated flame retardant added to building insulation foams, electronics, and textiles. HBCD is a commercial-mixture (CM-HBCD) composed of 3 main stereoisomers: α-HBCD (10%); β-HBCD (10%); γ-HBCD (80%). A shift from the dominant stereoisomer γ-HBCD to α-HBCD is detected in humans and wildlife. OBJECTIVES: Considering CM-HBCD has been implicated in neurodevelopment and endocrine disruption, with expected metabolism perturbations, metabolomics was performed on mice serum obtained during a window-of-developmental neurotoxicity to draw correlations between early-life exposures, developmental outcomes, and predict health risks...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814245/effects-of-periconception-cadmium-and-mercury-co-administration-to-mice-on-indices-of-chronic-disease-in-male-offspring-at-maturity
#2
Cagri Camsari, Joseph K Folger, Devin McGee, Steven J Bursian, Hongbing Wang, Jason G Knott, George W Smith
BACKGROUND: Long-term exposure to the heavy metals cadmium (Cd) and mercury (Hg) is known to increase risk of chronic diseases. However, to our knowledge, exposure to Cd and Hg beginning at the periconception period has not been studied to date. OBJECTIVE: The effect of co-administration of Cd and Hg during early development on indices of chronic diseases at adulthood was examined. METHODS: Adult female CD1 mice were subcutaneously administered a combination of cadmium chloride (CdCl2) and methylmercury (II) chloride (CH3HgCl; 0, 0...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814244/combined-effects-of-in-utero-and-adolescent-tobacco-smoke-exposure-on-lung-function-in-c57bl-6j-mice
#3
David Drummond, Mélissa Baravalle-Einaudi, Guillaume Lezmi, Shamila Vibhushan, Marie-Laure Franco-Montoya, Alice Hadchouel, Jorge Boczkowski, Christophe Delacourt
BACKGROUND: Foetal determinants of airway function, such as in utero exposure to maternal cigarette smoke (CS), may create a predisposition to adult airflow obstruction and COPD in adulthood. It has been suggested that active smoking in adolescence and pre-existing airflow obstruction have synergistic deleterious effects. OBJECTIVE: We used a mouse model to investigate whether there is a synergistic effect of exposure to CS in utero and during adolescence on lung function...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814243/nanomaterials-vs-ambient-ultrafine-particles-an-opportunity-to-exchange-toxicology-knowledge
#4
REVIEW
Vicki Stone, Mark R Miller, Martin J D Clift, Alison Elder, Nicholas L Mills, Peter Møller, Roel P F Schins, Ulla Vogel, Wolfgang G Kreyling, Keld Alstrup Jensen, Thomas A J Kuhlbusch, Per E Schwarze, Peter Hoet, Antonio Pietroiusti, Andrea De Vizcaya-Ruiz, Armelle Baeza-Squiban, C Lang Tran, Flemming R Cassee
BACKGROUND: A rich literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), with strong support for an important role for ultrafine (nano-sized) particles. At present, relatively little human health or epidemiology data exists for engineered nanomaterials (NM) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available in a range of physicochemical characteristics which allow a more systematic toxicological analysis...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814242/neonatal-cord-blood-oxylipins-and-exposure-to-particulate-matter-in-the-early-life-environment-an-environage-birth-cohort-study
#5
Dries S Martens, Sandra Gouveia, Narjes Madhloum, Bram G Janssen, Michelle Plusquin, Charlotte Vanpoucke, Wouter Lefebvre, Bertil Forsberg, Malin Nording, Tim S Nawrot
BACKGROUND: As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. OBJECTIVES: We studied the association between in utero PM2.5 (particulate matter with aerodynamic diameter <2.5µm) exposure and oxylipin profiles in newborns. METHODS: Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX) and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27791981/advancing-alternative-analysis-integration-of-decision-science
#6
REVIEW
Timothy F Malloy, Virginia M Zaunbrecher, Christina Batteate, Ann Blake, William F Carroll, Charles J Corbett, Steffen Foss Hansen, Robert Lempert, Igor Linkov, Roger McFadden, Kelly D Moran, Elsa Olivetti, Nancy Ostrom, Michelle Romero, Julie Schoenung, Thomas Seager, Peter Sinsheimer, Kristina Thayer
BACKGROUND: Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals. OBJECTIVES: Assess whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics...
October 28, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27753429/the-prevalence-of-antibiotic-resistant-staphylococcus-aureus-nasal-carriage-among-industrial-hog-operation-workers-community-residents-and-children-living-in-their-households-north-carolina-usa
#7
Sarah M Hatcher, Sarah M Rhodes, Jill R Stewart, Ellen Silbergeld, Nora Pisanic, Jesper Larsen, Sharon Jiang, Amanda Krosche, Devon Hall, Karen C Carroll, Christopher D Heaney
BACKGROUND: Antibiotic use in industrial hog operations (IHOs) can support the emergence of antibiotic-resistant (ABR) Staphylococcus aureus. The extent of ABR S. aureus exposure in IHO workers and children living in their households remains unclear. OBJECTIVE: To investigate ABR S. aureus nasal carriage prevalence among adults with versus without occupational exposure to IHOs and among children living in their households. METHODS: In total, 198 IHO worker-child household pairs and 202 community referent (CR) adult-child household pairs completed a questionnaire and provided a nasal swab which was analyzed for S...
October 18, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27740511/sex-specific-associations-between-particulate-matter-exposure-and-gene-expression-in-independent-discovery-and-validation-cohorts-of-middle-aged-men-and-women
#8
Karen Vrijens, Ellen Winckelmans, Maria Tsamou, Willy Baeyens, Patrick De Boever, Danyel Jennen, Theo M de Kok, Elly Den Hond, Wouter Lefebvre, Michelle Plusquin, Hans Reynders, Greet Schoeters, Nicolas Van Larebeke, Charlotte Vanpoucke, Jos Kleinjans, Tim S Nawrot
BACKGROUND: Particulate matter (PM) exposure leads to premature death, mainly due to respiratory and cardiovascular diseases. OBJECTIVES: Identification of transcriptomic biomarkers of air pollution exposure and effect in a healthy adult population. METHODS: Microarray analyses were performed in 98 healthy volunteers (48 men, 50 women). The expression of 8 sex-specific candidate biomarker genes (significantly associated with PM10 in the discovery cohort and with a reported link to air pollution-related disease) was measured with qPCR in an independent validation cohort (75 men, 94 women)...
October 14, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27740510/prenatal-exposure-to-glycol-ethers-and-neurocognitive-abilities-in-6-year-old-children-the-pelagie-cohort-study
#9
Rémi Béranger, Ronan Garlantézec, Gaïd Le Maner-Idrissi, Agnès Lacroix, Florence Rouget, Jessica Trowbridge, Charline Warembourg, Christine Monfort, Florent Le Gléau, Marylène Jourdin, Luc Multigner, Sylvaine Cordier, Cécile Chevrier
BACKGROUND: Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES: We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother-child cohort. METHODS: Five GE metabolites were measured in first-void urine samples of 204 French pregnant women in early pregnancy (<19 weeks of gestation)...
October 14, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27735790/poultry-consumption-and-arsenic-exposure-in-the-u-s-population
#10
Anne E Nigra, Keeve E Nachman, David C Love, Maria Grau-Perez, Ana Navas-Acien
BACKGROUND: Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. The association between poultry intake and exposure to these arsenic species, as reflected in elevated urinary arsenic concentrations, however, is unknown. OBJECTIVES: Evaluate the association between 24-hour dietary recall of poultry consumption and arsenic exposure in the U...
October 13, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27735789/nitarsone-inorganic-arsenic-and-other-arsenic-species-in-turkey-meat-exposure-and-risk-assessment-based-on-a-2014-u-s-market-basket-sample
#11
Keeve E Nachman, David C Love, Patrick A Baron, Anne E Nigra, Manuela Murko, Georg Raber, Kevin A Francesconi, Ana Navas-Acien
BACKGROUND: Use of nitarsone, an arsenic-based poultry drug, may result in dietary exposures to inorganic arsenic (iAs) and other arsenic species. Nitarsone was withdrawn from the US market in 2015, but use in other countries may continue. OBJECTIVES: Characterize the impact of nitarsone use on arsenic species in turkey meat and arsenic exposures among turkey consumers, and estimate cancer risk increases from consuming turkey treated with nitarsone prior to its 2015 US withdrawal...
October 13, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713111/air-pollution-and-deaths-among-elderly-residents-of-s%C3%A3-o-paulo-brazil-an-analysis-of-mortality-displacement
#12
Amine Farias Costa, Gerard Hoek, Bert Brunekreef, Antônio Cm Ponce de Leon
BACKGROUND: Evaluation of short-term mortality displacement is essential to accurately estimate the impact of short-term air pollution exposure on public health. OBJECTIVES: To quantify mortality displacement by estimating single-day lag effects and cumulative effects of air pollutants on mortality using distributed lag models. METHODS: We performed a daily time series of non-accidental and cause-specific mortality among elderly residents of São Paulo, Brazil, between 2000 and 2011...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713110/the-associations-between-environmental-quality-and-mortality-in-the-contiguous-united-states-2000-2005
#13
Yun Jian, Lynne C Messer, Jyotsna S Jagai, Kristen M Rappazzo, Christine L Gray, Shannon C Grabich, Danelle T Lobdell
BACKGROUND: Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. OBJECTIVES: This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. METHODS: We used the overall Environmental Quality Index (EQI) and its five domain indices (air, water, land, built and sociodemographic) to represent environmental exposure...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713109/population-level-exposure-to-particulate-air-pollution-during-active-travel-planning-for-low-exposure-health-promoting-cities
#14
Steve Hankey, Greg Lindsey, Julian D Marshall
BACKGROUND: Providing infrastructure and land uses to encourage active travel (i.e., bicycling and walking) are promising strategies for designing health-promoting cities. Population-level exposure to air pollution during active travel is understudied. OBJECTIVES: To (1) investigate population-level patterns in exposure during active travel, based on spatial estimates of bicycle traffic, pedestrian traffic, and particulate concentrations; and, (2) assess how those exposure patterns are associated with the built environment...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713108/chronic-exposure-to-low-doses-of-dioxin-promotes-liver-fibrosis-development-in-the-c57bl6-j-diet-induced-obesity-mouse-model
#15
Caroline Duval, Fatima Teixeira-Clerc, Alix F Leblanc, Sothea Touch, Claude Emond, Michèle Guerre-Millo, Sophie Lotersztajn, Robert Barouki, Martine Aggerbeck, Xavier Coumoul
BACKGROUND: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, yet the contribution of POPs to the development of fibrosis in non-alcoholic fatty liver disease (NAFLD), a condition closely linked to obesity, remains poorly documented. OBJECTIVES: We investigated the effects of subchronic exposure to low-doses of the POP 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor ligand, on NAFLD progression in diet-induced obese C57BL/6J mice...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713107/a-longitudinal-study-of-peripubertal-serum-organochlorine-concentrations-and-semen-parameters-in-young-men-the-russian-children-s-study
#16
Lidia Mínguez-Alarcón, Oleg Sergeyev, Jane S Burns, Paige L Williams, Mary M Lee, Susan A Korrick, Luidmila Smigulina, Boris Revich, Russ Hauser
BACKGROUND: Exposures to endocrine disrupting chemicals during critical phases of testicular development may be related to poorer semen parameters. However, few studies have assessed the association between childhood organochlorine (OC) exposure and adult semen parameters. OBJECTIVE: We examined whether peripubertal serum OC concentrations are associated with semen parameters among young Russian men. METHODS: From 2003 to 2005, 516 boys were enrolled at age 8-9 years and followed for up to ten years...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713106/an-analysis-of-the-potential-impact-of-climate-change-on-dengue-transmission-in-the-southeastern-united-states
#17
Melinda K Butterworth, Cory W Morin, Andrew C Comrie
BACKGROUND: Dengue fever, caused by a mosquito-transmitted virus, is an increasing health concern in the Americas. Meteorological variables such as temperature and precipitation can impact disease distribution and abundance through biophysical impacts on the vector and virus. Such tightly coupled links may facilitate further spread of dengue fever under a changing climate. In the southeastern United States, the dengue vector is widely established and exists on the current fringe of dengue transmission...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27713105/associations-between-long-term-particulate-matter-exposure-and-adult-renal-function-in-the-taipei-metropolis
#18
Ya-Ru Yang, Yung-Ming Chen, Szu-Ying Chen, Chang-Chuan Chan
BACKGROUND: This study aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. METHODS: We recruited 21,656 adults as subjects from 2007-2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m(2) were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter <10 μm (PM10), coarse particles (PMCoarse), fine particles (PM2...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27697747/are-fish-consumption-advisories-for-the-great-lakes-adequately-protective-from-chemical-mixture
#19
Nilima Gandhi, Ken G Drouillard, George B Arhonditsis, Sarah B Gewurtz, Satyendra P Bhavsar
BACKGROUND: North American Great Lakes are home to more than 140 types of fish and are famous for recreational and commercial fishing. However, presence of toxic substances has resulted in issuance of fish consumption advisories typically based on the most restrictive contaminant. OBJECTIVES: We investigate if these advisories, which typically neglect existence of a mixture of chemicals and their possible additive adverse effects, are adequately protective of health of humans consuming fish from the Canadian waters of the Great Lakes...
October 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27649448/airborne-fine-particles-and-risk-of-hospital-admissions-for-understudied-populations-effects-by-urbanicity-and-short-term-cumulative-exposures-in-708-u-s-counties
#20
Mercedes A Bravo, Keita Ebisu, Francesca Dominici, Yun Wang, Roger D Peng, Michelle L Bell
BACKGROUND: Evidence of health risks associated with ambient airborne fine particles in nonurban populations is extremely limited. OBJECTIVE: We estimate risk of hospitalization associated with short-term exposures to particulate matter with an aerodynamic diameter <2.5μ (PM2.5) in urban and nonurban counties with population ≥50,000. METHODS: We utilize a database of daily cardiovascular- and respiratory-related hospitalization rates constructed from Medicare National Claims History files (2002-2006), including 28 million Medicare beneficiaries in 708 counties...
September 20, 2016: Environmental Health Perspectives
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