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Environmental Health Perspectives

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https://www.readbyqxmd.com/read/30632786/a-chemical-category-based-prioritization-approach-for-selecting-75-per-and-polyfluoroalkyl-substances-pfas-for-tiered-toxicity-and-toxicokinetic-testing
#1
Grace Patlewicz, Ann M Richard, Antony J Williams, Christopher M Grulke, Reeder Sams, Jason Lambert, Pamela D Noyes, Michael J DeVito, Ronald N Hines, Mark Strynar, Annette Guiseppi-Elie, Russell S Thomas
Per- and polyfluoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. A few PFASs have comparatively extensive amounts of human epidemiological, exposure, and experimental animal toxicity data (e.g., perfluorooctanoic acid), whereas little toxicity and exposure information exists for much of the broader set of PFASs. Given that traditional approaches to generate toxicity information are resource intensive, new approach methods, including in vitro high-throughput toxicity (HTT) testing, are being employed to inform PFAS hazard characterization and further ( in vivo) testing...
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30628845/exposure-to-perfluoroalkyl-substances-during-fetal-life-and-pubertal-development-in-boys-and-girls-from-the-danish-national-birth-cohort
#2
Andreas Ernst, Nis Brix, Lea Lykke Braskhøj Lauridsen, Jørn Olsen, Erik Thorup Parner, Zeyan Liew, Lars Henning Olsen, Cecilia Høst Ramlau-Hansen
BACKGROUND: It remains unsettled whether prenatal exposure to perfluoroalkyl substances (PFASs) affects human reproductive health through potential endocrine disruption. OBJECTIVES: We aimed to explore the associations between prenatal exposure to several PFASs and various aspects of pubertal development in boys and girls. METHODS: We studied two samples ([Formula: see text] and 445) from the Puberty Cohort, nested within the Danish National Birth Cohort (DNBC), measuring PFAS in maternal plasma from early gestation...
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30624099/longitudinal-seasonal-and-occupational-trends-of-multiple-pesticides-in-house-dust
#3
Breana Bennett, Tomomi Workman, Marissa N Smith, William C Griffith, Beti Thompson, Elaine M Faustman
BACKGROUND: Children are especially vulnerable to pesticide exposure and can suffer lasting health effects. Because children of farmworkers are exposed to a variety of pesticides throughout development, it is important to explore temporal patterns of coexposures. OBJECTIVES: The objectives of this study were to characterize the pesticide co-exposures, determine how they change over time, and assess differences between farmworker and nonfarmworker households. METHODS: Dust collected from 40 farmworker and 35 nonfarmworker households in the Yakima Valley of the State of Washington in 2005 and then again in 2011 was analyzed for 99 pesticides...
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30624098/prenatal-exposure-to-select-phthalates-and-phenols-and-associations-with-fetal-and-placental-weight-among-male-births-in-the-eden-cohort-france
#4
Claire Philippat, Barbara Heude, Jérémie Botton, Nadia Alfaidy, Antonia M Calafat, Rémy Slama
BACKGROUND: The placenta performs crucial physiological functions to ensure normal fetal development. Few epidemiological studies investigated placental weight sensitivity to phthalates and phenols. OBJECTIVE: Our goal was to explore whether maternal exposure to select phthalates and phenols is associated with changes in placental weight at birth and in placental-to-birth weight ratio (PFR). METHODS: Placental weight and birth weight were available for 473 mother-son pairs in the EDEN (Etude des Déterminants pré et postnatals du développement et de la santé de l'Enfant) cohort for whom 9 phenols (4 parabens, 2 dichlorophenols, triclosan, benzophenone-3, bisphenol A) and 11 phthalate metabolites were measured in spot urine samples collected between weeks 23 and 29 of gestation...
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30620213/erratum-associations-between-repeated-measures-of-maternal-urinary-phthalate-metabolites-and-thyroid-hormone-parameters-during-pregnancy
#5
Lauren E Johns, Kelly K Ferguson, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
No abstract text is available yet for this article.
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30620212/geographic-demographic-and-temporal-variations-in-the-association-between-heat-exposure-and-hospitalization-in-brazil-a-nationwide-study-between-2000-and-2015
#6
Qi Zhao, Shanshan Li, Micheline S Z S Coelho, Paulo H N Saldiva, Kejia Hu, Julie M Arblaster, Neville Nicholls, Rachel R Huxley, Michael J Abramson, Yuming Guo
BACKGROUND: Limited evidence is available regarding the association between heat exposure and morbidity in Brazil and how the effect of heat exposure on health outcomes may change over time. OBJECTIVES: This study sought to quantify the geographic, demographic and temporal variations in the heat-hospitalization association in Brazil from 2000-2015. METHODS: Data on hospitalization and meteorological conditions were collected from 1,814 cities during the 2000-2015 hot seasons...
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30620211/erratum-urinary-phthalate-metabolites-and-biomarkers-of-oxidative-stress-in-pregnant-women-a-repeated-measures-analysis
#7
Kelly K Ferguson, Thomas F McElrath, Yin-Hsiu Chen, Bhramar Mukherjee, John D Meeker
No abstract text is available yet for this article.
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30620210/erratum-urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#8
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
No abstract text is available yet for this article.
January 2019: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30575420/a-natural-conclusion-when-teens-rank-green-space-very-important-they-visit-more
#9
Carol Potera
No abstract text is available yet for this article.
December 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30570336/effects-of-indoor-and-ambient-black-carbon-and-formula-see-text-on-pulmonary-function-among-individuals-with-copd
#10
Jaime E Hart, Stephanie T Grady, Francine Laden, Brent A Coull, Petros Koutrakis, Joel D Schwartz, Marilyn L Moy, Eric Garshick
BACKGROUND: Particulate matter (PM) air pollution has been associated with decreased pulmonary function, but the exposure-response relationship in chronic obstructive pulmonary disease (COPD) patients is uncertain, and most studies have only focused on exposures to ambient pollution. OBJECTIVES: We aimed to assess associations between pulmonary function and indoor and ambient PM [Formula: see text] ([Formula: see text]) and black carbon (BC). METHODS: Between November 2012 and December 2014, 125 patients with COPD (mean age, 73...
December 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30566375/long-term-exposure-to-ultrafine-particles-and-incidence-of-cardiovascular-and-cerebrovascular-disease-in-a-prospective-study-of-a-dutch-cohort
#11
George S Downward, Erik J H M van Nunen, Jules Kerckhoffs, Paolo Vineis, Bert Brunekreef, Jolanda M A Boer, Kyle P Messier, Ananya Roy, W Monique M Verschuren, Yvonne T van der Schouw, Ivonne Sluijs, John Gulliver, Gerard Hoek, Roel Vermeulen
BACKGROUND: There is growing evidence that exposure to ultrafine particles (UFP; particles smaller than [Formula: see text]) may play an underexplored role in the etiology of several illnesses, including cardiovascular disease (CVD). OBJECTIVES: We aimed o investigate the relationship between long-term exposure to ambient UFP and incident cardiovascular and cerebrovascular disease (CVA). As a secondary objective, we sought to compare effect estimates for UFP with those derived for other air pollutants, including estimates from two-pollutant models...
December 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30561225/best-practices-for-qsar-model-reporting-physical-and-chemical-properties-ecotoxicity-environmental-fate-human-health-and-toxicokinetics-endpoints
#12
Geven Piir, Iiris Kahn, Alfonso T García-Sosa, Sulev Sild, Priit Ahte, Uko Maran
BACKGROUND: Quantitative and qualitative structure-activity relationships (QSARs) have been used to understand chemical behavior for almost a century. The main source of QSAR models is the scientific literature, but the open question is how well these models are documented. OBJECTIVES: The main aim of this study was to critically analyze the publication practices of QSARs with regard to transparency, potential reproducibility, and independent verification. The focus was on the level of technical completeness of the published QSARs...
December 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30540492/advancements-in-life-cycle-human-exposure-and-toxicity-characterization
#13
Peter Fantke, Lesa Aylward, Jane Bare, Weihsueh A Chiu, Robin Dodson, Robert Dwyer, Alexi Ernstoff, Brett Howard, Matti Jantunen, Olivier Jolliet, Richard Judson, Nienke Kirchhübel, Dingsheng Li, Aubrey Miller, Greg Paoli, Paul Price, Lorenz Rhomberg, Beverly Shen, Hyeong-Moo Shin, Justin Teeguarden, Daniel Vallero, John Wambaugh, Barbara A Wetmore, Rosemary Zaleski, Thomas E McKone
BACKGROUND: The Life Cycle Initiative, hosted at the United Nations Environment Programme, selected human toxicity impacts from exposure to chemical substances as an impact category that requires global guidance to overcome current assessment challenges. The initiative leadership established the Human Toxicity Task Force to develop guidance on assessing human exposure and toxicity impacts. Based on input gathered at three workshops addressing the main current scientific challenges and questions, the task force built a roadmap for advancing human toxicity characterization, primarily for use in life cycle impact assessment (LCIA)...
December 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30526050/erratum-prenatal-exposure-to-nonpersistent-endocrine-disruptors-and-behavior-in-boys-at-3-and-5-years
#14
Claire Philippat, Dorothy Nakiwala, Antonia M Calafat, Jérémie Botton, Maria De Agostini, Barbara Heude, Rémy Slama
No abstract text is available yet for this article.
December 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30499692/promotional-consideration-a-potential-mechanistic-link-between-neonicotinoid-insecticides-and-hormone-dependent-breast-cancer
#15
Silke Schmidt
No abstract text is available yet for this article.
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30484712/erratum-prenatal-exposure-to-ddt-and-pyrethroids-for-malaria-control-and-child-neurodevelopment-the-vhembe-cohort-south-africa
#16
Brenda Eskenazi, Sookee An, Stephen A Rauch, Eric S Coker, Angelina Maphula, Muvhulawa Obida, Madelein Crause, Katherine R Kogut, Riana Bornman, Jonathan Chevrier
No abstract text is available yet for this article.
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30465702/a-prospective-study-of-environmental-exposures-and-early-biomarkers-in-autism-spectrum-disorder-design-protocols-and-preliminary-data-from-the-marbles-study
#17
Irva Hertz-Picciotto, Rebecca J Schmidt, Cheryl K Walker, Deborah H Bennett, McKenzie Oliver, Kristine M Shedd-Wise, Janine M LaSalle, Cecilia Giulivi, Birgit Puschner, Jennifer Thomas, Dorcas L Roa, Isaac N Pessah, Judy Van de Water, Daniel J Tancredi, Sally Ozonoff
BACKGROUND: Until recently, environmental factors in autism spectrum disorder (ASD) were largely ignored. Over the last decade, altered risks from lifestyle, medical, chemical, and other factors have emerged through various study designs: whole population cohorts linked to diagnostic and/or exposure-related databases, large case-control studies, and smaller cohorts of children at elevated risk for ASD. OBJECTIVES: This study aimed to introduce the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) prospective study and its goals, motivate the enhanced-risk cohort design, describe protocols and main exposures of interest, and present initial descriptive results for the study population...
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30457876/the-brain-before-birth-using-fmri-to-explore-the-secrets-of-fetal-neurodevelopment
#18
Lindsey Konkel
No abstract text is available yet for this article.
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30417653/conditioning-on-parity-in-studies-of-perfluoroalkyl-acids-and-time-to-pregnancy-an-example-from-the-danish-national-birth-cohort
#19
Cathrine Carlsen Bach, Niels Bjerregård Matthiesen, Jørn Olsen, Tine Brink Henriksen
BACKGROUND: Previous studies have investigated the associations between perfluoroalkyl acids (PFAAs) in women and time to pregnancy (TTP). Inconsistent results may be explained by differences in conditioning on parity. OBJECTIVES: We used causal directed acyclic graphs to illustrate potential confounding related to previous pregnancies and exposure measurement error due to differences in the interpregnancy interval in pregnancy-based studies that include parous women...
November 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/30398377/signaling-events-downstream-of-ahr-activation-that-contribute-to-toxic-responses-the-functional-role-of-an-ahr-dependent-long-noncoding-rna-slincr-using-the-zebrafish-model
#20
Gloria R Garcia, Prarthana Shankar, Cheryl L Dunham, Abraham Garcia, Jane K La Du, Lisa Truong, Susan C Tilton, Robert L Tanguay
BACKGROUND: A structurally diverse group of chemicals, including dioxins [e.g., 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)] and polycyclic aromatic hydrocarbons (PAHs), can xenobiotically activate the aryl hydrocarbon receptor (AHR) and contribute to adverse health effects in humans and wildlife. In the zebrafish model, repression of sox9b has a causal role in several AHR-mediated toxic responses, including craniofacial cartilage malformations; however, the mechanism of sox9b repression remains unknown...
November 2018: Environmental Health Perspectives
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