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Environmental Health Perspectives

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https://www.readbyqxmd.com/read/27814246/serum-metabolomic-profiles-in-neonatal-mice-following-oral-brominated-flame-retardant-exposures-to-hexabromocyclododecane-hbcd-alpha-gamma-and-commercial-mixture
#1
David T Szabo, Wimal Pathmasiri, Susan Sumner, Linda S Birnbaum
BACKGROUND: Hexabromocyclododecane (HBCD) is a high production volume brominated flame retardant added to building insulation foams, electronics, and textiles. HBCD is a commercial-mixture (CM-HBCD) composed of 3 main stereoisomers: α-HBCD (10%); β-HBCD (10%); γ-HBCD (80%). A shift from the dominant stereoisomer γ-HBCD to α-HBCD is detected in humans and wildlife. OBJECTIVES: Considering CM-HBCD has been implicated in neurodevelopment and endocrine disruption, with expected metabolism perturbations, metabolomics was performed on mice serum obtained during a window-of-developmental neurotoxicity to draw correlations between early-life exposures, developmental outcomes, and predict health risks...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814245/effects-of-periconception-cadmium-and-mercury-co-administration-to-mice-on-indices-of-chronic-disease-in-male-offspring-at-maturity
#2
Cagri Camsari, Joseph K Folger, Devin McGee, Steven J Bursian, Hongbing Wang, Jason G Knott, George W Smith
BACKGROUND: Long-term exposure to the heavy metals cadmium (Cd) and mercury (Hg) is known to increase risk of chronic diseases. However, to our knowledge, exposure to Cd and Hg beginning at the periconception period has not been studied to date. OBJECTIVE: The effect of co-administration of Cd and Hg during early development on indices of chronic diseases at adulthood was examined. METHODS: Adult female CD1 mice were subcutaneously administered a combination of cadmium chloride (CdCl2) and methylmercury (II) chloride (CH3HgCl; 0, 0...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814244/combined-effects-of-in-utero-and-adolescent-tobacco-smoke-exposure-on-lung-function-in-c57bl-6j-mice
#3
David Drummond, Mélissa Baravalle-Einaudi, Guillaume Lezmi, Shamila Vibhushan, Marie-Laure Franco-Montoya, Alice Hadchouel, Jorge Boczkowski, Christophe Delacourt
BACKGROUND: Foetal determinants of airway function, such as in utero exposure to maternal cigarette smoke (CS), may create a predisposition to adult airflow obstruction and COPD in adulthood. It has been suggested that active smoking in adolescence and pre-existing airflow obstruction have synergistic deleterious effects. OBJECTIVE: We used a mouse model to investigate whether there is a synergistic effect of exposure to CS in utero and during adolescence on lung function...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814243/nanomaterials-vs-ambient-ultrafine-particles-an-opportunity-to-exchange-toxicology-knowledge
#4
REVIEW
Vicki Stone, Mark R Miller, Martin J D Clift, Alison Elder, Nicholas L Mills, Peter Møller, Roel P F Schins, Ulla Vogel, Wolfgang G Kreyling, Keld Alstrup Jensen, Thomas A J Kuhlbusch, Per E Schwarze, Peter Hoet, Antonio Pietroiusti, Andrea De Vizcaya-Ruiz, Armelle Baeza-Squiban, C Lang Tran, Flemming R Cassee
BACKGROUND: A rich literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), with strong support for an important role for ultrafine (nano-sized) particles. At present, relatively little human health or epidemiology data exists for engineered nanomaterials (NM) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available in a range of physicochemical characteristics which allow a more systematic toxicological analysis...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27814242/neonatal-cord-blood-oxylipins-and-exposure-to-particulate-matter-in-the-early-life-environment-an-environage-birth-cohort-study
#5
Dries S Martens, Sandra Gouveia, Narjes Madhloum, Bram G Janssen, Michelle Plusquin, Charlotte Vanpoucke, Wouter Lefebvre, Bertil Forsberg, Malin Nording, Tim S Nawrot
BACKGROUND: As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. OBJECTIVES: We studied the association between in utero PM2.5 (particulate matter with aerodynamic diameter <2.5µm) exposure and oxylipin profiles in newborns. METHODS: Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX) and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27791981/advancing-alternative-analysis-integration-of-decision-science
#6
REVIEW
Timothy F Malloy, Virginia M Zaunbrecher, Christina Batteate, Ann Blake, William F Carroll, Charles J Corbett, Steffen Foss Hansen, Robert Lempert, Igor Linkov, Roger McFadden, Kelly D Moran, Elsa Olivetti, Nancy Ostrom, Michelle Romero, Julie Schoenung, Thomas Seager, Peter Sinsheimer, Kristina Thayer
BACKGROUND: Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals. OBJECTIVES: Assess whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics...
October 28, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055950/response-to-comment-on-individual-and-neighborhood-socioeconomic-status-and-the-association-between-air-pollution-and-cardiovascular-disease
#7
Gloria C Chi, Anjum Hajat, Kristin A Miller, Eric A Whitsel, Beth Ann Griffin, Regina A Shih, Joel D Kaufman
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055949/in-memoriam-steve-wing
#8
Virginia T Guidry
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055948/exploring-chemical-transport-through-food-a-proposal-for-a-comprehensive-approach-to-predict-exposures
#9
Nate Seltenrich
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055947/implementation-science-to-accelerate-clean-cooking-for-public-health
#10
Joshua Rosenthal, Kalpana Balakrishnan, Nigel Bruce, David Chambers, Jay Graham, Darby Jack, Lydia Kline, Omar Masera, Sumi Mehta, Ilse Ruiz Mercado, Gila Neta, Subhrendu Pattanayak, Elisa Puzzolo, Helen Petach, Antonello Punturieri, Adolfo Rubinstein, Michael Sage, Rachel Sturke, Anita Shankar, Kenny Sherr, Kirk Smith, Gautam Yadama
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055946/reply-to-comment-on-on-the-utility-of-toxcast%C3%A2-and-toxpi-as-methods-for-identifying-new-obesogens
#11
Amanda S Janesick, Giorgio Dimastrogiovanni, Raquel Chamorro-Garcia, Bruce Blumberg
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055945/comment-on-individual-and-neighborhood-socioeconomic-status-and-the-association-between-air-pollution-and-cardiovascular-disease
#12
Tara Ahmed, Heval Mohamed Kelli, Pratik Sandesara
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055944/comment-on-on-the-utility-of-toxcast%C3%A2-and-toxpi-as-methods-for-identifying-new-obesogens
#13
Keith A Houck, Richard S Judson, Thomas B Knudsen, Matthew T Martin, Ann M Richard, Kevin M Crofton, Anton Simeonov, Richard S Paules, John R Bucher, Russell S Thomas
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055943/fallout-from-european-fires-an-estimate-of-premature-deaths-attributable-to-vegetation-smoke
#14
Nancy Averett
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28055942/hot-days-in-early-pregnancy-a-potential-risk-factor-for-congenital-heart-defects
#15
Lindsey Konkel
No abstract text is available yet for this article.
January 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27494594/risk-of-congenital-heart-defects-after-ambient-heat-exposure-early-in-pregnancy
#16
Nathalie Auger, William D Fraser, Reg Sauve, Marianne Bilodeau-Bertrand, Tom Kosatsky
BACKGROUND: Congenital heart defects may be environmentally related, but the association with elevated ambient temperature has received little attention. OBJECTIVES: We studied the relationship between outdoor heat during the first trimester of pregnancy and risk of congenital heart defects. METHODS: We carried out a retrospective cohort study of 704,209 fetuses between 2 and 8 weeks postconception from April to September in Quebec, Canada, 1988-2012...
January 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27494442/perinatal-exposure-to-traffic-related-air-pollution-and-autism-spectrum-disorders
#17
Tong Gong, Christina Dalman, Susanne Wicks, Henrik Dal, Cecilia Magnusson, Cecilia Lundholm, Catarina Almqvist, Göran Pershagen
BACKGROUND: Studies from the United States indicate that exposure to air pollution in early life is associated with autism spectrum disorders (ASD) in children, but the evidence is not consistent with European data. OBJECTIVE: We aimed to investigate the association between exposure to air pollution from road traffic and the risk of ASD in children, with careful adjustment for socioeconomic and other confounders. METHOD: Children born and residing in Stockholm, Sweden, during 1993-2007 with an ASD diagnosis were identified through multiple health registers and classified as cases (n = 5,136)...
January 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27472655/mortality-due-to-vegetation-fire-originated-pm2-5-exposure-in-europe-assessment-for-the-years-2005-and-2008
#18
Virpi Kollanus, Marje Prank, Alexandra Gens, Joana Soares, Julius Vira, Jaakko Kukkonen, Mikhail Sofiev, Raimo O Salonen, Timo Lanki
BACKGROUND: Vegetation fires can release substantial quantities of fine particles (PM2.5), which are harmful to health. The fire smoke may be transported over long distances and can cause adverse health effects over wide areas. OBJECTIVE: We aimed to assess annual mortality attributable to short-term exposures to vegetation fire-originated PM2.5 in different regions of Europe. METHODS: PM2.5 emissions from vegetation fires in Europe in 2005 and 2008 were evaluated based on Moderate Resolution Imaging Spectroradiometer (MODIS) satellite data on fire radiative power...
January 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27448387/epigenome-wide-meta-analysis-of-methylation-in-children-related-to-prenatal-no2-air-pollution-exposure
#19
Olena Gruzieva, Cheng-Jian Xu, Carrie V Breton, Isabella Annesi-Maesano, Josep M Antó, Charles Auffray, Stéphane Ballereau, Tom Bellander, Jean Bousquet, Mariona Bustamante, Marie-Aline Charles, Yvonne de Kluizenaar, Herman T den Dekker, Liesbeth Duijts, Janine F Felix, Ulrike Gehring, Mònica Guxens, Vincent V W Jaddoe, Soesma A Jankipersadsing, Simon Kebede Merid, Juha Kere, Ashish Kumar, Nathanael Lemonnier, Johanna Lepeule, Wenche Nystad, Christian Magnus Page, Sviatlana Panasevich, Dirkje Postma, Rémy Slama, Jordi Sunyer, Cilla Söderhäll, Jin Yao, Stephanie J London, Göran Pershagen, Gerard H Koppelman, Erik Melén
BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years...
January 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27448386/in-utero-exposure-to-benzo-a-pyrene-increases-mutation-burden-in-the-soma-and-sperm-of-adult-mice
#20
Matthew J Meier, Jason M O'Brien, Marc A Beal, Beverly Allan, Carole L Yauk, Francesco Marchetti
BACKGROUND: Mosaicism, the presence of genetically distinct cell populations within an organism, has emerged as an important contributor to disease. Mutational events occurring during embryonic development can cause mosaicism in any tissue, but the influence of environmental factors on levels of mosaicism is unclear. OBJECTIVES: We investigated whether in utero exposure to the widespread environmental mutagen benzo[a]pyrene (BaP) has an impact on the burden and distribution of mutations in adult mice...
January 2017: Environmental Health Perspectives
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