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Environmental Health Perspectives

Stephanie M Engel, Gro D Villanger, Rachel C Nethery, Cathrine Thomsen, Amrit K Sakhi, Samantha S M Drover, Jane A Hoppin, Pal Zeiner, Gun Peggy Knudsen, Ted Reichborn-Kjennerud, Amy H Herring, Heidi Aase
BACKGROUND: There is growing concern that phthalate exposures may have an impact on child neurodevelopment. Prenatal exposure to phthalates has been linked with externalizing behaviors and executive functioning defects suggestive of an attention-deficit hyperactivity disorder (ADHD) phenotype. OBJECTIVES: We undertook an investigation into whether prenatal exposure to phthalates was associated with clinically confirmed ADHD in a population-based nested case-control study of the Norwegian Mother and Child Cohort (MoBa) between the years 2003 and 2008...
May 10, 2018: Environmental Health Perspectives
Rebecca Bentley, Tony Blakely, Anne Kavanagh, Zoe Aitken, Tania King, Paul McElwee, Billie Giles-Corti, Gavin Turrell
BACKGROUND: Societies face the challenge of keeping people active as they age. Walkable neighborhoods have been associated with physical activity, but more rigorous analytical approaches are needed. OBJECTIVES: We used longitudinal data from adult residents of Brisbane, Australia (40-65 years of age at baseline) to estimate effects of changes in neighborhood characteristics over a 6-y period on the likelihood of walking for transport. METHODS: Analyses included 2,789-9,747 How Areas Influence Health and Activity (HABITAT) cohort participants from 200 neighborhoods at baseline (2007) who completed up to three follow-up questionnaires (through 2013)...
May 3, 2018: Environmental Health Perspectives
Medina S Jackson-Browne, George D Papandonatos, Aimin Chen, Antonia M Calafat, Kimberly Yolton, Bruce P Lanphear, Joseph M Braun
BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age...
May 2, 2018: Environmental Health Perspectives
Yeonseung Chung, Daewon Yang, Antonio Gasparrini, Ana M Vicedo-Cabrera, Chris Fook Sheng Ng, Yoonhee Kim, Yasushi Honda, Masahiro Hashizume
BACKGROUND: Previous studies have shown that population susceptibility to non-optimum temperatures has changed over time, but little is known about the related time-varying factors that underlie the changes. OBJECTIVE: Our objective was to investigate the changing population susceptibility to non-optimum temperatures in 47 prefectures of Japan over four decades from 1972 to 2012, addressing three aspects: minimum mortality temperature (MMT) and heat- and cold-related mortality risks...
May 2, 2018: Environmental Health Perspectives
Lin-Ying Cao, Xiao-Min Ren, Yu Yang, Bin Wan, Liang-Hong Guo, De Chen, Yong Fan
BACKGROUND: Numerous studies have indicated the estrogenic effects of polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs (OH-PBDEs). However, the previous mechanistic studies focused on their estrogenic effects through genomic transcriptional activation of estrogen receptors. OBJECTIVE: The present study aimed to investigate the estrogenic effects of PBDEs and OH-PBDEs via nongenomic G protein-coupled estrogen receptor (GPER) pathways. METHODS: The binding affinities of 12 PBDEs and 18 OH-PBDEs with GPER were determined by a fluorescence competitive binding assay in a human breast cancer cell line (SKBR3)...
May 2018: Environmental Health Perspectives
Raquel Chamorro-García, Bassem M Shoucri, Sigal Willner, Heidi Käch, Amanda Janesick, Bruce Blumberg
BACKGROUND: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, in construction materials, and in medical devices. Previous animal studies showed detrimental effects of DBT during in utero development at relatively high doses, but little was known about the effects of DBT exposure at environmentally relevant doses on endpoints such as obesity and metabolic disease. OBJECTIVES: We tested the potential obesogenic effects of DBT using in vitro and in vivo models...
May 2018: Environmental Health Perspectives
Lizan D Bloemsma, Ulrike Gehring, Jochem O Klompmaker, Gerard Hoek, Nicole A H Janssen, Henriëtte A Smit, Judith M Vonk, Bert Brunekreef, Erik Lebret, Alet H Wijga
BACKGROUND: Green space may influence health through several pathways, for example, increased physical activity, enhanced social cohesion, reduced stress, and improved air quality. For green space to increase physical activity and social cohesion, spending time in green spaces is likely to be important. OBJECTIVES: We examined whether adolescents visit green spaces and for what purposes. Furthermore, we assessed the predictors of green space visits. METHODS: In this cross-sectional study, data for 1911 participants of the Dutch PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort were analyzed...
April 30, 2018: Environmental Health Perspectives
Ma Wan, Brian D Bennett, Gary S Pittman, Michelle R Campbell, Lindsay M Reynolds, Devin K Porter, Christopher L Crowl, Xuting Wang, Dan Su, Neal A Englert, Isabel J Thompson, Yongmei Liu, Douglas A Bell
BACKGROUND: Cigarette smoke is a causal factor in cancers and cardiovascular disease. Smoking-associated differentially methylated regions (SM-DMRs) have been observed in disease studies, but the causal link between altered DNA methylation and transcriptional change is obscure. OBJECTIVE: Our objectives were to finely resolve SM-DMRs and to interrogate the mechanistic link between SM-DMRs and altered transcription of enhancer noncoding RNA (eRNA) and mRNA in human circulating monocytes...
April 27, 2018: Environmental Health Perspectives
Élyse Caron-Beaudoin, Rachel Viau, J Thomas Sanderson
BACKGROUND: Aromatase (CYP19) is a key enzyme in estrogens biosynthesis. In the mammary gland, CYP19 gene is expressed at low levels under the regulation of its I.4 promoter. In hormone-dependent breast cancer, fibroblast cells surrounding the tumor express increased levels of CYP19 mRNA due to a decrease of I.4 promoter activity and an increase of PII, I.3, and I.7 promoter activity. Little is known about the effects of environmental chemicals on the promoter-specific CYP19 expression...
April 26, 2018: Environmental Health Perspectives
Humberto Parada, Marilie D Gammon, Jia Chen, Antonia M Calafat, Alfred I Neugut, Regina M Santella, Mary S Wolff, Susan L Teitelbaum
BACKGROUND: Phthalates, known endocrine disruptors, may play a role in breast carcinogenesis. Few studies have examined phthalates in relation to breast cancer (BC), and, to our knowledge, none have considered survival following BC. OBJECTIVES: We examined 11 urinary phthalate metabolites, individually and as molar sum groupings, in association with BC incidence and subsequent survival. METHODS: Our study includes 710 women diagnosed with first primary BC in 1996-1997 and 598 women without BC from Long Island, New York...
April 26, 2018: Environmental Health Perspectives
Sharon K Sagiv, Maria H Harris, Robert B Gunier, Katherine R Kogut, Kim G Harley, Julianna Deardorff, Asa Bradman, Nina Holland, Brenda Eskenazi
BACKGROUND: Prenatal exposure to organophosphate (OP) pesticides has been linked with poorer neurodevelopment and behaviors related to autism spectrum disorders (ASD) in previous studies, including in the Center for Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort living in the agricultural Salinas Valley in California. OBJECTIVES: To investigate the association of prenatal exposure to OP pesticides with traits related to ASD, in childhood and adolescents in CHAMACOS...
April 25, 2018: Environmental Health Perspectives
Jori Lewis
No abstract text is available yet for this article.
April 25, 2018: Environmental Health Perspectives
Wendee Nicole
No abstract text is available yet for this article.
April 23, 2018: Environmental Health Perspectives
Ariadna Garcia-Saenz, Alejandro Sánchez de Miguel, Ana Espinosa, Antonia Valentin, Núria Aragonés, Javier Llorca, Pilar Amiano, Vicente Martín Sánchez, Marcela Guevara, Rocío Capelo, Adonina Tardón, Rosana Peiró-Perez, José Juan Jiménez-Moleón, Aina Roca-Barceló, Beatriz Pérez-Gómez, Trinidad Dierssen-Sotos, Tania Fernández-Villa, Conchi Moreno-Iribas, Victor Moreno, Javier García-Pérez, Gemma Castaño-Vinyals, Marina Pollán, Martin Aubé, Manolis Kogevinas
BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013...
April 23, 2018: Environmental Health Perspectives
Qi Zhao, Shanshan Li, Wei Cao, De-Li Liu, Quan Qian, Hongyan Ren, Fan Ding, Gail Williams, Rachel Huxley, Wenyi Zhang, Yuming Guo
BACKGROUND: There is limited evidence about the association between ambient temperature and the incidence of pediatric hand, foot, and mouth disease (HFMD) nationwide in China. OBJECTIVES: We examined the childhood temperature-HFMD associations across mainland China, and we projected the change in HFMD cases due to projected temperature change by the 2090s. METHODS: Data on daily HFMD (children 0-14 y old) counts and weather were collected from 362 sites during 2009-2014...
April 20, 2018: Environmental Health Perspectives
Todd J Zurlinden, Brad Reisfeld
BACKGROUND: Organophosphorus (OP) compounds are the most widely used group of insecticides in the world. Risk assessments for these chemicals have focused primarily on 10% inhibition of acetylcholinesterase in the brain as the critical metric of effect. Aside from cholinergic effects resulting from acute exposure, many studies suggest a linkage between cognitive deficits and long-term OP exposure. OBJECTIVE: In this proof-of-concept study, we focused on one of the most widely used OP insecticides in the world, chlorpyrifos (CPF), and utilized an existing physiologically based pharmacokinetic (PBPK) model and a novel pharmacodynamic (PD) dose-response model to develop a point of departure benchmark dose estimate for cognitive deficits following long-term, low-dose exposure to this chemical in rodents...
April 20, 2018: Environmental Health Perspectives
Catherine Bouchard, Cécile Aenishaenslin, Erin E Rees, Jules K Koffi, Yann Pelcat, Marion Ripoche, François Milord, L Robbin Lindsay, Nicholas H Ogden, Patrick A Leighton
BACKGROUND: The risk of contracting Lyme disease (LD) can vary spatially because of spatial heterogeneity in risk factors such as social-behavior and exposure to ecological risk factors. Integrating these risk factors to inform decision-making should therefore increase the effectiveness of mitigation interventions. OBJECTIVES: The objective of this study was to develop an integrated social-behavioral and ecological risk-mapping approach to identify priority areas for LD interventions...
April 18, 2018: Environmental Health Perspectives
David Mills, Russell Jones, Cameron Wobus, Julia Ekstrom, Lesley Jantarasami, Alexis St Juliana, Allison Crimmins
BACKGROUND: The public health community readily recognizes flooding and wildfires as climate-related health hazards, but few studies quantify changes in risk of exposure, particularly for vulnerable children and older adults. OBJECTIVES: This study quantifies future populations potentially exposed to inland flooding and wildfire smoke under two climate scenarios, highlighting the populations in particularly vulnerable age groups (≤4 y old and ≥65 y old)...
April 17, 2018: Environmental Health Perspectives
Pablo Hurtado-Gonzalez, Richard A Anderson, Joni Macdonald, Sander van den Driesche, Karen Kilcoyne, Anne Jørgensen, Chris McKinnell, Sheila Macpherson, Richard M Sharpe, Rod T Mitchell
BACKGROUND: Analgesic exposure during pregnancy may affect aspects of fetal gonadal development that are targeted by endocrine disruptors. OBJECTIVES: We investigated whether therapeutically relevant doses of acetaminophen and ibuprofen affect germ cell (GC) development in human fetal testes/ovaries using in vitro and xenograft approaches. METHODS: First-trimester human fetal testes/ovaries were cultured and exposed to acetaminophen or ibuprofen (7 d)...
April 16, 2018: Environmental Health Perspectives
Carol Potera
No abstract text is available yet for this article.
April 16, 2018: Environmental Health Perspectives
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