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Environmental Health Perspectives

Sarah M Hatcher, Sarah M Rhodes, Jill R Stewart, Ellen Silbergeld, Nora Pisanic, Jesper Larsen, Sharon Jiang, Amanda Krosche, Devon Hall, Karen C Carroll, Christopher D Heaney
BACKGROUND: Antibiotic use in industrial hog operations (IHOs) can support the emergence of antibiotic-resistant (ABR) Staphylococcus aureus. The extent of ABR S. aureus exposure in IHO workers and children living in their households remains unclear. OBJECTIVE: To investigate ABR S. aureus nasal carriage prevalence among adults with versus without occupational exposure to IHOs and among children living in their households. METHODS: In total, 198 IHO worker-child household pairs and 202 community referent (CR) adult-child household pairs completed a questionnaire and provided a nasal swab which was analyzed for S...
October 18, 2016: Environmental Health Perspectives
Karen Vrijens, Ellen Winckelmans, Maria Tsamou, Willy Baeyens, Patrick De Boever, Danyel Jennen, Theo M de Kok, Elly Den Hond, Wouter Lefebvre, Michelle Plusquin, Hans Reynders, Greet Schoeters, Nicolas Van Larebeke, Charlotte Vanpoucke, Jos Kleinjans, Tim S Nawrot
BACKGROUND: Particulate matter (PM) exposure leads to premature death, mainly due to respiratory and cardiovascular diseases. OBJECTIVES: Identification of transcriptomic biomarkers of air pollution exposure and effect in a healthy adult population. METHODS: Microarray analyses were performed in 98 healthy volunteers (48 men, 50 women). The expression of 8 sex-specific candidate biomarker genes (significantly associated with PM10 in the discovery cohort and with a reported link to air pollution-related disease) was measured with qPCR in an independent validation cohort (75 men, 94 women)...
October 14, 2016: Environmental Health Perspectives
Rémi Béranger, Ronan Garlantézec, Gaïd Le Maner-Idrissi, Agnès Lacroix, Florence Rouget, Jessica Trowbridge, Charline Warembourg, Christine Monfort, Florent Le Gléau, Marylène Jourdin, Luc Multigner, Sylvaine Cordier, Cécile Chevrier
BACKGROUND: Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES: We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother-child cohort. METHODS: Five GE metabolites were measured in first-void urine samples of 204 French pregnant women in early pregnancy (<19 weeks of gestation)...
October 14, 2016: Environmental Health Perspectives
Anne E Nigra, Keeve E Nachman, David C Love, Maria Grau-Perez, Ana Navas-Acien
BACKGROUND: Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. The association between poultry intake and exposure to these arsenic species, as reflected in elevated urinary arsenic concentrations, however, is unknown. OBJECTIVES: Evaluate the association between 24-hour dietary recall of poultry consumption and arsenic exposure in the U...
October 13, 2016: Environmental Health Perspectives
Keeve E Nachman, David C Love, Patrick A Baron, Anne E Nigra, Manuela Murko, Georg Raber, Kevin A Francesconi, Ana Navas-Acien
BACKGROUND: Use of nitarsone, an arsenic-based poultry drug, may result in dietary exposures to inorganic arsenic (iAs) and other arsenic species. Nitarsone was withdrawn from the US market in 2015, but use in other countries may continue. OBJECTIVES: Characterize the impact of nitarsone use on arsenic species in turkey meat and arsenic exposures among turkey consumers, and estimate cancer risk increases from consuming turkey treated with nitarsone prior to its 2015 US withdrawal...
October 13, 2016: Environmental Health Perspectives
Amine Farias Costa, Gerard Hoek, Bert Brunekreef, Antônio Cm Ponce de Leon
BACKGROUND: Evaluation of short-term mortality displacement is essential to accurately estimate the impact of short-term air pollution exposure on public health. OBJECTIVES: To quantify mortality displacement by estimating single-day lag effects and cumulative effects of air pollutants on mortality using distributed lag models. METHODS: We performed a daily time series of non-accidental and cause-specific mortality among elderly residents of São Paulo, Brazil, between 2000 and 2011...
October 7, 2016: Environmental Health Perspectives
Yun Jian, Lynne C Messer, Jyotsna S Jagai, Kristen M Rappazzo, Christine L Gray, Shannon C Grabich, Danelle T Lobdell
BACKGROUND: Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. OBJECTIVES: This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. METHODS: We used the overall Environmental Quality Index (EQI) and its five domain indices (air, water, land, built and sociodemographic) to represent environmental exposure...
October 7, 2016: Environmental Health Perspectives
Steve Hankey, Greg Lindsey, Julian D Marshall
BACKGROUND: Providing infrastructure and land uses to encourage active travel (i.e., bicycling and walking) are promising strategies for designing health-promoting cities. Population-level exposure to air pollution during active travel is understudied. OBJECTIVES: To (1) investigate population-level patterns in exposure during active travel, based on spatial estimates of bicycle traffic, pedestrian traffic, and particulate concentrations; and, (2) assess how those exposure patterns are associated with the built environment...
October 7, 2016: Environmental Health Perspectives
Caroline Duval, Fatima Teixeira-Clerc, Alix F Leblanc, Sothea Touch, Claude Emond, Michèle Guerre-Millo, Sophie Lotersztajn, Robert Barouki, Martine Aggerbeck, Xavier Coumoul
BACKGROUND: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, yet the contribution of POPs to the development of fibrosis in non-alcoholic fatty liver disease (NAFLD), a condition closely linked to obesity, remains poorly documented. OBJECTIVES: We investigated the effects of subchronic exposure to low-doses of the POP 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor ligand, on NAFLD progression in diet-induced obese C57BL/6J mice...
October 7, 2016: Environmental Health Perspectives
Lidia Mínguez-Alarcón, Oleg Sergeyev, Jane S Burns, Paige L Williams, Mary M Lee, Susan A Korrick, Luidmila Smigulina, Boris Revich, Russ Hauser
BACKGROUND: Exposures to endocrine disrupting chemicals during critical phases of testicular development may be related to poorer semen parameters. However, few studies have assessed the association between childhood organochlorine (OC) exposure and adult semen parameters. OBJECTIVE: We examined whether peripubertal serum OC concentrations are associated with semen parameters among young Russian men. METHODS: From 2003 to 2005, 516 boys were enrolled at age 8-9 years and followed for up to ten years...
October 7, 2016: Environmental Health Perspectives
Melinda K Butterworth, Cory W Morin, Andrew C Comrie
BACKGROUND: Dengue fever, caused by a mosquito-transmitted virus, is an increasing health concern in the Americas. Meteorological variables such as temperature and precipitation can impact disease distribution and abundance through biophysical impacts on the vector and virus. Such tightly coupled links may facilitate further spread of dengue fever under a changing climate. In the southeastern United States, the dengue vector is widely established and exists on the current fringe of dengue transmission...
October 7, 2016: Environmental Health Perspectives
Ya-Ru Yang, Yung-Ming Chen, Szu-Ying Chen, Chang-Chuan Chan
BACKGROUND: This study aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. METHODS: We recruited 21,656 adults as subjects from 2007-2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m(2) were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter <10 μm (PM10), coarse particles (PMCoarse), fine particles (PM2...
October 7, 2016: Environmental Health Perspectives
Nilima Gandhi, Ken G Drouillard, George B Arhonditsis, Sarah B Gewurtz, Satyendra P Bhavsar
BACKGROUND: North American Great Lakes are home to more than 140 types of fish and are famous for recreational and commercial fishing. However, presence of toxic substances has resulted in issuance of fish consumption advisories typically based on the most restrictive contaminant. OBJECTIVES: We investigate if these advisories, which typically neglect existence of a mixture of chemicals and their possible additive adverse effects, are adequately protective of health of humans consuming fish from the Canadian waters of the Great Lakes...
October 4, 2016: Environmental Health Perspectives
Mercedes A Bravo, Keita Ebisu, Francesca Dominici, Yun Wang, Roger D Peng, Michelle L Bell
BACKGROUND: Evidence of health risks associated with ambient airborne fine particles in nonurban populations is extremely limited. OBJECTIVE: We estimate risk of hospitalization associated with short-term exposures to particulate matter with an aerodynamic diameter <2.5μ (PM2.5) in urban and nonurban counties with population ≥50,000. METHODS: We utilize a database of daily cardiovascular- and respiratory-related hospitalization rates constructed from Medicare National Claims History files (2002-2006), including 28 million Medicare beneficiaries in 708 counties...
September 20, 2016: Environmental Health Perspectives
Lauren J Donoghue, Thomas I Neufeld, Yin Li, Yukitomo Arao, Laurel A Coons, Kenneth S Korach
BACKGROUND: Endocrine disrupting compounds (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified ligand binding domain sequence. EDC activity through this isoform remains uncharacterized. OBJECTIVES: We identified the expression pattern of mERβ2 in mouse tissues and assessed the estrogenic activity of EDCs through mERβ2...
September 16, 2016: Environmental Health Perspectives
Qian Ba, Mian Li, Peizhan Chen, Chao Huang, Xiaohua Duan, Lijun Lu, Jingquan Li, Ruiai Chu, Dong Xie, Haiyun Song, Yongning Wu, Hao Ying, Xudong Jia, Hui Wang
BACKGROUND: Environmental cadmium, with a high average dietary intake, is a severe public health risk. However, the long-term health implications of environmental exposure to cadmium in different life stages remain unclear. OBJECTIVES: To investigate the effects of early exposure to cadmium, at an environmentally relevant dosage, on adult metabolism and the mechanism of action. METHODS: We established mouse models with low-dose cadmium (LDC) exposure in early life to examine the long-term metabolic consequences...
September 16, 2016: Environmental Health Perspectives
Amy J Pickering, Benjamin F Arnold, Holly N Dentz, John M Colford, Clair Null
BACKGROUND: The recent global climate agreement in Paris aims to mitigate greenhouse gas emissions while fostering sustainable development, and establishes an international trading mechanism to meet this goal. Currently, carbon offset program implementers are allowed to collect their own monitoring data to determine the number of carbon credits to be awarded. OBJECTIVES: We summarize reasons for mandating independent monitoring of greenhouse gas emission reduction projects...
September 16, 2016: Environmental Health Perspectives
Guangyun Mao, Rebecca Massa Nachman, Qi Sun, Xingyou Zhang, Kirsten Koehler, Zhu Chen, Xiumei Hong, Guoying Wang, Deanna Caruso, Geng Zong, Colleen Pearson, Hongkai Ji, Shyam Biswal, Barry Zuckerman, Marsha Wills-Karp, Xiaobin Wang
BACKGROUND: Although previous studies suggest that exposure to traffic-related pollution during childhood increases risk of childhood overweight or obesity (COWO), the role of early-life exposure to fine particulate matter (aerodynamic diameter <2.5 micrometers, PM2.5) and its joint effect with mother's pre-pregnancy body mass index (MPBMI) on COWO remain unclear. OBJECTIVES: The present study was conducted to examine the individual and joint effects of ambient PM2...
September 16, 2016: Environmental Health Perspectives
Bram G Janssen, Nelly D Saenen, Harry A Roels, Narjes Madhloum, Wilfried Gyselaers, Wouter Lefebvre, Joris Penders, Charlotte Vanpoucke, Karen Vrijens, Tim S Nawrot
BACKGROUND: Thyroid hormones are critical for fetal development and growth. Whether prenatal exposure to fine particle air pollution (PM2.5) affects fetal thyroid function and what the impact is on birth weight in normal healthy pregnancies is not studied yet. OBJECTIVES: To study the impact of third trimester PM2.5 exposure on fetal and maternal thyroid hormones and their mediating role on birth weight. METHODS: We measured the levels of free thyroid hormones (FT3, FT4) and thyroid stimulating hormone (TSH) in cord blood (n = 499) and maternal blood (n = 431) collected after delivery from mother-child pairs enrolled between February 2010 and June 2014 in the ENVIRONAGE birth cohort with catchment area in the province of Limburg, Belgium...
September 13, 2016: Environmental Health Perspectives
Nelly D Saenen, Karen Vrijens, Bram G Janssen, Harry A Roels, Kristof Y Neven, Wim Vanden Berghe, Wilfried Gyselaers, Charlotte Vanpoucke, Wouter Lefebvre, Patrick De Boever, Tim S Nawrot
BACKGROUND: Particulate matter with a diameter ≤ 2.5 µm (PM2.5) affects human fetal development during pregnancy. Oxidative stress is a putative mechanism by which PM2.5 may exert its effects. Leptin (LEP) is an energy regulating hormone involved in fetal growth and development. OBJECTIVES: We investigated in placental tissue whether DNA methylation of the LEP promoter is associated with PM2.5 and whether the oxidative/nitrosative stress biomarker 3-nitrotyrosine (3-NTp) is involved...
September 13, 2016: Environmental Health Perspectives
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