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Heart & Lung: the Journal of Critical Care

Benjamin J Tarrant, Caitlin Le Maitre, Lorena Romero, Ranjana Steward, Brenda M Button, Bruce R Thompson, Anne E Holland
BACKGROUND AND OBJECTIVES: Inhaled mucoactive agents are used to enhance airway clearance, however efficacy and safety are unclear in adults with acute respiratory conditions. METHODS: We systematically reviewed randomized controlled trials assessing respiratory function; safety; length of stay (LOS); mucus; radiology; and oxygenation. RESULTS: No adverse events were reported for dornase alfa (n = 63), N-acetylcysteine (NAC, n = 50), ambroxol (n = 140), hypertonic saline (n = 33), heparin (n = 384), mannitol (n = 20) or isotonic saline...
November 5, 2018: Heart & Lung: the Journal of Critical Care
Beth Towery Davidson
No abstract text is available yet for this article.
November 1, 2018: Heart & Lung: the Journal of Critical Care
Agata Galas, Paweł Krzesiński, Grzegorz Gielerak, Wiesław Piechota, Beata Uziębło-Życzkowska, Adam Stańczyk, Katarzyna Piotrowicz, Małgorzata Banak
BACKGROUND: Acute decompensated heart failure (ADHF) is a serious clinical problem and a condition requiring immediate diagnostics, supporting the therapeutic decision adequate to the specific ADHF mechanism. N-terminal pro-brain natriuretic peptide (NT-proBNP) is an established biochemical marker of heart failure, strongly related to hemodynamic status. Impedance cardiography (ICG) provides non-invasive hemodynamic assessment that can be performed immediately at the bedside and revealed to be useful diagnostic tool in some clinical settings in cardiology...
October 31, 2018: Heart & Lung: the Journal of Critical Care
Yanhong Ren, Junke Qiu, Zelin Li, Cheng Li
OBJECTIVES: The purpose of this study is to explore the value of P-wave terminal force in lead V1 (PTFV1) in the clinical diagnosis of tuberculous constrictive pericarditis (TCP). METHODS: A total of 53 patients with TCP and 64 patients with tuberculous exudative pericarditis were enrolled in this retrospective study. The demographic and clinical characteristics were collected, including gender, age, the course of disease and New York Heart Association (NYHA) classification...
October 31, 2018: Heart & Lung: the Journal of Critical Care
Ulf Nilsson, Isabel Kanerud, Ulla-Britt Diamant, Anders Blomberg, Berne Eriksson, Anne Lindberg
BACKGROUND: The role of QTc-prolongation, in relation to the increased mortality in COPD, is unclear. OBJECTIVES: To estimate the prevalence and prognostic impact, assessed as mortality, of QTc-prolongation in COPD, restrictive spirometric pattern (RSP), and normal lung function (NLF), respectively. METHODS: All individuals (n = 993) with COPD and age- and sex-matched non-obstructive referents were identified from well-defined population-based cohorts examined in Northern Sweden in 2002-04...
October 31, 2018: Heart & Lung: the Journal of Critical Care
Andrew Bugajski, Susan K Frazier, Debra K Moser, Terry A Lennie, Misook Chung
BACKGROUND: Chronic disease self-management is complex and multidimensional. Optimal performance of self-management behaviors requires support from patient's friends, family, and significant others. The Multidimensional Scale of Perceived Social Support (MSPSS) is a 12-item questionnaire used to measure patient's social support from friends, family, and significant others. OBJECTIVES: To examine the psychometric properties of the MSPSS in patients with comorbid chronic obstructive pulmonary disease (COPD) and heart failure (HF)...
October 31, 2018: Heart & Lung: the Journal of Critical Care
Voratima Silavanich, Surakit Nathisuwan, Arintaya Phrommintikul, Unchalee Permsuwan
BACKGROUND: Little is known regarding the relationship between medication adherence and quality of life in heart failure patients. We therefore aimed to examine the nature of relationship between medication adherence and quality of life. METHODS: A prospective, cross-sectional study of chronic heart failure patients with reduced ejection fraction was performed at a tertiary-care, university hospital in Thailand. Quality of life and medication adherence were assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Morisky Medication Adherence Scale-8 (MMAS-8), respectively...
October 29, 2018: Heart & Lung: the Journal of Critical Care
Xianghui Zheng, Yang Zheng, Jing Ma, Maomao Zhang, Yongxiang Zhang, Xianglan Liu, Liangqi Chen, Qingyuan Yang, Yong Sun, Jian Wu, Bo Yu
BACKGROUND: Cardiac rehabilitation (CR) has been shown to provide the best social, psychological and physical conditions for patient recovery after myocardial infarction (MI). OBJECTIVES: The aim of present study was to quantify the efficacy of exercise-based CR treatments in terms of relief from symptoms of anxiety and depression symptoms among patients with MI. METHODS: Literature published up to August 2017 was reviewed systematically using relevant keywords, MeSH terms, and Emtree headings to search PubMed, Embase, CINAHL (Ebsco), Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science...
October 23, 2018: Heart & Lung: the Journal of Critical Care
Ailar Ramadi, Robert G Haennel
BACKGROUND: There is a deleterious association between sedentary behavior and mortality risk factors. Elevated sedentary time has been reported in several studies that involved cardiac rehabilitation (CR) participants. OBJECTIVES: To examine the changes in sedentary behavior, breaks in sedentary time, and physical activity (PA) in CR participants. METHODS: This was a prospective repeated measures study. Sedentary behavior and PA were assessed using accelerometer at baseline, 12 weeks, and 6 months after CR entry...
October 23, 2018: Heart & Lung: the Journal of Critical Care
Adelita Tinoco, David W Mortara, Xiao Hu, Cass Piper Sandoval, Michele M Pelter
BACKGROUND: Cheyne-Stokes respiration and periodic breathing (CSRPB) have not been studied sufficiently in the intensive care unit setting (ICU). OBJECTIVES: To determine whether CSRPB is associated with adverse outcomes in ICU patients. METHODS: The ICU group was divided into quartiles by CSRPB (86 patients in quartile 1 had the least CSRPB and 85 patients in quartile 4 had the most CSRPB). Adverse outcomes (emergent intubation, cardiorespiratory arrest, inpatient mortality and the composite of all) were compared between patients with most CSRPB (quartile 4) and those with least CSRPB (quartile 1)...
October 16, 2018: Heart & Lung: the Journal of Critical Care
Beatriz S Ribeiro, Agnaldo J Lopes, Sara L S Menezes, Fernando S Guimarães
BACKGROUND: Ventilator hyperinflation (VHI) is effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated subjects; however, there are no recommendations for the best ventilator settings to perform the technique. OBJECTIVE: To compare six modes of VHI, concerning physiological markers of efficacy and safety criteria to support the selection of optimal settings. METHODS: Thirty mechanically ventilated patients underwent six modes of VHI in a randomized order...
October 15, 2018: Heart & Lung: the Journal of Critical Care
Ruohui Wang, Changkun Pan, Xiaokun Wang, Feng Xu, Shuang Jiang, Ming Li
BACKGROUND: The optimal timing of tracheotomy in critically ill ventilated patients remains controversial. OBJECTIVES: The objective of this meta-analysis was to assess tracheotomy timing for critically ill ventilated patients and determine the outcomes' reliability. METHODS: We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials. RESULTS: Compared with late tracheotomy, early tracheotomy presented a lower incidence of ventilator-associated pneumonia (VAP), shorter duration of mechanical ventilation (MV), and shorter intensive care unit (ICU) stay...
October 15, 2018: Heart & Lung: the Journal of Critical Care
Lucyna Tomaszek, Grażyna Dębska, Grażyna Cepuch, Marlena Kulpa, Lidia Pawlik, Elżbieta Broniatowska
BACKGROUND: Cystic fibrosis (CF) is a chronic disease that has an impact on Health-Related Quality of Life (HRQoL). OBJECTIVES: To identify demographic and clinical factors associated with HRQoL in adolescents and young adults with CF. METHODS: The sample comprised adolescent and young adult patients with CF. They completed the Cystic Fibrosis Quality of Life (CFQoL) questionnaire, which includes Physical, Social, Treatment, Chest Symptoms, Emotional Functioning, Future Concerns, Relationships, Body Image, and Career dimensions...
October 10, 2018: Heart & Lung: the Journal of Critical Care
Binu Koirala, Cheryl Dennison Himmelfarb, Chakra Budhathoki, Thitipong Tankumpuan, Reiko Asano, Patricia M Davidson
No abstract text is available yet for this article.
October 10, 2018: Heart & Lung: the Journal of Critical Care
Christopher S Lee, Quin E Denfeld, Bradley E Aouizerat, Corrine Y Jurgens, Christopher V Chien, Emily Aarons, Jill M Gelow, Shirin O Hiatt, James O Mudd
BACKGROUND: We have a limited understanding of the biological underpinnings of symptoms in heart failure (HF). OBJECTIVES: The purpose of this paper was to compare relationships between peripheral biomarkers of HF pathogenesis and physical symptoms between patients with advanced versus moderate HF. METHODS: This was a two-stage phenotype sampling cohort study wherein we examined patients with advanced HF undergoing ventricular assist device implantation in the first stage, and then patients with moderate HF (matched adults with HF not requiring device implantation) in the second stage...
October 9, 2018: Heart & Lung: the Journal of Critical Care
Diana Rivero, Mohammad Alhamaydeh, Ziad Faramand, Mohammad Alrawashdeh, Christian Martin-Gill, Clifton Callaway, Barbara Drew, Salah Al-Zaiti
BACKGROUND: Nonspecific ST-T repolarization (NST) abnormalities alter the ST-segment for reasons often unrelated to acute myocardial ischemia, which could contribute to misdiagnosis or inappropriate treatment. We sought to define the prevalence of NST patterns in patients with chest pain and evaluate how such patterns correlate with the eventual etiology of chest pain and course of hospitalization. METHODS: This was a prospective observational study that included consecutive prehospital chest pain patients from three tertiary care hospitals in the U...
October 8, 2018: Heart & Lung: the Journal of Critical Care
Rachel J Le, Carolyn M Larsen, Eric R Fenstad, Robert B McCully, Robert P Frantz, Michael D McGoon, Garvan C Kane
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive vascular disorder with a high mortality. Clinical experience and small case series suggest thrombocytopenia may be frequent in this population and associated with a poor prognosis. We sought to estimate the prevalence of thrombocytopenia in patients with PAH and characterize its association with disease characteristics and patient outcome. METHODS: Single center cohort study of 714 incident adult patients with Group 1 PH who were evaluated for baseline platelet count at the time of diagnosis...
October 6, 2018: Heart & Lung: the Journal of Critical Care
Koji Ueyama, So Miyahara, Yujiro Ide, Kazuhisa Sakamoto, Hideo Kanemitsu, Kazuhiro Yamazaki, Tadashi Ikeda, Akihiro Aoyama, Hiroshi Date, Kenji Minatoya
No abstract text is available yet for this article.
October 4, 2018: Heart & Lung: the Journal of Critical Care
Kasra Moazzami, Elena V Dolmatova, Alfonso H Waller
No abstract text is available yet for this article.
September 27, 2018: Heart & Lung: the Journal of Critical Care
Mai Kimura, Takashi Kohno, Shinji Makino, Shigeo Okuda, Kan Nawata, Ryo Yanagisawa, Hidenori Kojima, Takahiko Nishiyama, Yoshiyasu Aizawa, Shinsuke Yuasa, Mitsushige Murata, Yuichiro Maekawa, Kazuma Okamoto, Hideyuki Shimizu, Keiichi Fukuda
Hypertrophic cardiomyopathy (HCM) is an extremely heterogeneous genetic disease that affects the left ventricle (LV) and has a varied clinical course and phenotypic expression. Here, we report a case of two sisters with HCM who developed a massive refractory left atrial appendage (LAA) thrombus and recurrent embolism. The older sister, who was at a high surgical risk due to progressive LV systolic dysfunction with an ejection fraction of 19%, underwent LAA plication in combination with implantation of an LV assist device after progression to treatment-refractory heart failure at the age of 49...
September 22, 2018: Heart & Lung: the Journal of Critical Care
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