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Thrombosis Research

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https://www.readbyqxmd.com/read/28343143/impact-of-rivaroxaban-on-point-of-care-assays
#1
Pierre Fontana, Lorenzo Alberio, Anne Angelillo-Scherrer, Lars M Asmis, Wolfgang Korte, Adriana Mendez, Pirmin Schmid, Hans Stricker, Jan-Dirk Studt, Dimitrios A Tsakiris, Walter A Wuillemin, Michael Nagler
BACKGROUND: Point-of-care testing (POCT) is regularly used to assess haemostasis in various clinical settings. The impact of rivaroxaban on those POCT is still elusive. We aimed to study the effects of rivaroxaban on most commonly used POCT assays. METHODS: Blood samples were taken before, 3h, and 24h after administration of 20mg rivaroxaban to 20 healthy volunteers as part of a prospective, multicenter validation study (clinicaltrials.govNCT01710267). Blood samples were analysed with thromboelastometry (ROTEM®), two platelet function assays (INNOVANCE® PFA-200 and Multiplate®), and the CoaguChek® XS...
March 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28334639/inferior-vena-cava-filters-in-patients-with-cancer-and-venous-thromboembolism-vte-does-not-improve-clinical-outcomes-a-population-based-study
#2
Ann Brunson, Gwendolyn Ho, Richard White, Ted Wun
BACKGROUND: There are few studies that have determined clinical outcomes following inferior vena cava filter (IVCF) insertion in cancer patients hospitalized for acute deep-vein-thrombosis (DVT) or pulmonary embolism (PE). METHODS AND RESULTS: We analyzed hospital discharge records of all patients with active cancer who were admitted to a California hospital specifically for acute DVT or PE between 2005 through 2009. Propensity and competing risk methodology were used to determine if IVCF-use lowered either 30-day mortality or the risk of recurrent PE, DVT, and major bleeding within 180days...
March 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28324767/the-health-assessment-questionnaire-disability-index-haq-di-as-a-valid-alternative-for-measuring-the-functional-capacity-of-people-with-haemophilia
#3
Hortensia De La Corte-Rodriguez, E Carlos Rodriguez-Merchan
BACKGROUND: There are several scales for evaluating the functional capacity of people with haemophilia (PWH). OBJECTIVE: To demonstrate the value and simplicity of the "Health Assessment Questionnaire Disability Index" (HAQ-DI) for making a functional assessment of persons with haemophilia (PWH) in those contexts in which the specific physical assessment scales cannot be used (the "World Federation of Haemophilia Physical Examination Score" (WFH-PES) and the "Haemophilia Joint Health Score 2...
March 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28324766/mean-platelet-volume-may-not-be-an-alternative-test-instead-of-platelet-aggregation-in-patients-with-venous-thromboembolism
#4
LETTER
Cengiz Beyan, Esin Beyan
No abstract text is available yet for this article.
March 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28318571/mean-platelet-volume-a-controversial-marker-of-platelets-that-requires-further-unpacking
#5
LETTER
Marja Puurunen, Andrew D Johnson
No abstract text is available yet for this article.
March 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28319824/effect-of-long-term-remote-ischaemic-conditioning-on-platelet-function-and-fibrinolysis-in-patients-with-chronic-ischaemic-heart-failure
#6
Kasper Pryds, Jacobina Kristiansen, Søs Neergaard-Petersen, Roni R Nielsen, Michael R Schmidt, Jens Refsgaard, Steen D Kristensen, Hans Erik Bøtker, Anne-Mette Hvas, Erik L Grove
INTRODUCTION: Remote ischaemic conditioning (RIC) protects against ischaemia-reperfusion injury through cellular protective pathways, but may also modulate haemostasis. We aimed to investigate the effect of long-term RIC on platelet function and fibrinolysis in patients with chronic ischaemic heart failure (CIHF). MATERIAL AND METHODS: In a prospective, outcome-assessor blinded, paired study, 16 patients with CIHF and 21 age- and gender-matched controls without ischaemic heart disease (IHD) were treated with RIC once daily for 28±4days...
March 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28319822/comparison-of-intravenous-versus-topical-tranexamic-acid-in-primary-total-hip-and-knee-arthroplasty-an-updated-meta-analysis
#7
REVIEW
Jinwei Xie, Qinsheng Hu, Qiang Huang, Jun Ma, Yiting Lei, Fuxing Pei
BACKGROUND: The appropriate route for administering tranexamic acid in primary total hip (THA) and knee arthroplasty (TKA) remains controversial. The purpose of this meta-analysis was to compare the efficacy and safety of topical or intravenous tranexamic acid. METHODS: PubMed, EMBASE, and the Cochrane Library databases were systematically searched for randomized controlled trials (RCTs) comparing topical and intravenous tranexamic acid following primary THA or TKA...
March 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28314138/depression-and-post-traumatic-stress-disorder-in-individuals-with-hereditary-hemorrhagic-telangiectasia-a-cross-sectional-survey
#8
Shruti Chaturvedi, Marianne Clancy, Nicole Schaefer, Olalekan Oluwole, Keith R McCrae
INTRODUCTION: Hereditary hemorrhagic telangiectasia (HHT) is characterized by frequent severe bleeding, particularly epistaxis, and life-threatening complications including stroke, brain abscess and heart failure. The psychological impact of HHT is not known. We conducted this cross sectional study to determine the prevalence of depression and post-traumatic stress disorder (PTSD) related to HHT. METHODS: A survey tool comprising demographic and clinical information and two validated self-administered questionnaires, the PTSD checklist for DSM-5 (PCL-5) and Beck Depression Inventory-II (BDI-II), was distributed to individuals with HHT...
March 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28319825/n-terminal-of-prohormone-brain-natriuretic-peptide-predicts-functional-limitation-one-year-following-pulmonary-embolism-results-from-the-elope-study
#9
LETTER
Kim Ma, Susan R Kahn, Andrew M Hirsch, Arash Akaberi, David R Anderson, Philip S Wells, Marc Rodger, Susan Solymoss, Michael J Kovacs, Lawrence Rudski, Avi Shimony, Carole Dennie, Chris Rush, Paul Hernandez, Shawn D Aaron, John T Granton
No abstract text is available yet for this article.
March 8, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28319823/catastrophic-antiphospholipid-syndrome-on-switching-from-warfarin-to-rivaroxaban
#10
LETTER
Maeve P Crowley, Maria J Cuadrado, Beverley J Hunt
No abstract text is available yet for this article.
March 8, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28314139/patients-experiences-of-atrial-fibrillation-and-non-vitamin-k-antagonist-oral-anticoagulants-noacs-and-their-educational-needs-a-qualitative-study
#11
Danielle E Clarkesmith, Gregory Y H Lip, Deirdre A Lane
PURPOSE: Qualitative research on atrial fibrillation (AF) patient's experiences and perceptions of taking the non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention is limited. This study explores patients' experiences of dabigatran and their recommendations for development of educational materials. PATIENTS AND METHODS: Semi-structured individual interviews with 8 warfarin-naive and 8 warfarin-experienced AF patients, using qualitative deductive thematic analysis...
March 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28267600/abo-blood-group-is-associated-with-peripheral-arterial-disease-in-african-americans-the-multi-ethnic-study-of-atherosclerosis-mesa
#12
Mindy M Pike, Nicholas B Larson, Christina L Wassel, Kevin P Cohoon, Michael Y Tsai, James S Pankow, Naomi Q Hanson, Paul A Decker, Cecilia Berardi, Kristine S Alexander, Mary Cushman, Neil A Zakai, Suzette J Bielinski
INTRODUCTION: Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. METHODS: The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45-84...
February 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28262568/a-bleeding-assessment-tool-correlates-with-intraoperative-blood-loss-in-children-and-adolescents-undergoing-major-spinal-surgery
#13
Jennifer M Anadio, Peter F Sturm, Johan M Forslund, Sunil Agarwal, Adam Lane, Cristina Tarango, Joseph S Palumbo
Screening laboratory studies for bleeding disorders are of little predictive value for operative bleeding risk in adults. Predicting perioperative bleeding in pediatric patients is particularly difficult as younger patients often have not had significant hemostatic challenges. This issue is distinctly important for high bleeding risk surgeries, such as major spinal procedures. The aim of this study was to determine if the score of a detailed bleeding questionnaire (BQ) correlated with surgical bleeding in pediatric patients undergoing major spinal surgery...
February 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28262567/evaluation-of-a-diagnostic-algorithm-for-heparin-induced-thrombocytopenia
#14
Maria Farm, Tamam Bakchoul, Tony Frisk, Karina Althaus, Alice Odenrick, Eva-Marie Norberg, Maria Berndtsson, Jovan P Antovic
INTRODUCTION: Heparin-Induced Thrombocytopenia (HIT) is a rare but serious immune-mediated complication of heparin treatment. HIT is characterized by an acute, transient prothrombotic state combined with thrombocytopenia and is caused by platelet-activating IgG antibodies that bind to complexes of heparin and platelet factor 4. The diagnosis of HIT relies on clinical presentation and the demonstration of HIT antibodies. One approach to improve the efficacy of laboratory analysis is to use a diagnostic algorithm...
February 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28254694/endurance-exercise-per-se-reduces-the-cardiovascular-risk-marker-t-pa-antigen-in-healthy-younger-overweight-men
#15
Else-Marie Bladbjerg, Jane Skov, Pernille Nordby, Bente Stallknecht
INTRODUCTION: The cardiovascular risk marker tissue plasminogen activator antigen (t-PA:Ag) can be reduced by long-term exercise interventions, but it is unknown, whether this is due to the weight loss induced by physical activity or due to the physical activity per se. MATERIALS AND METHODS: This was tested in 60 healthy, younger (20-40years), overweight (BMI: 25-30kg/m(2)) men randomly assigned to 12weeks of intervention in one of four groups: training (T); energy-reduced diet (D); training and increased diet (T-iD); sedentary lifestyle and unchanged diet (controls, C)...
February 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28242032/indications-complications-and-outcomes-of-inferior-vena-cava-filters-a-retrospective-study
#16
Andrew Wassef, Wendy Lim, Cynthia Wu
INTRODUCTION: Inferior vena cava filters are used to prevent embolization of a lower extremity deep vein thrombosis when the risk of pulmonary embolism is thought to be high. However, evidence is lacking for their benefit and guidelines differ on the recommended indications for filter insertion. The study aim was to determine the reasons for inferior vena cava filter placement and subsequent complication rate. MATERIALS AND METHODS: A retrospective cohort of patients receiving inferior vena cava filters in Edmonton, Alberta, Canada from 2007 to 2011...
February 20, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28249199/venous-thrombosis-in-children-and-adolescents-with-hodgkin-lymphoma-in-sweden
#17
A Schönning, J Karlén, T Frisk, M Heyman, J E Svahn, I Øra, L Kawan, B-M Holmqvist, C Björklund, A Harila-Saari, S Ranta
INTRODUCTION: Pediatric patients with Hodgkin lymphoma (HL) have several risk factors for venous thromboembolism (VTE). Although these patients are occasionally treated with thromboprophylaxis, no guidelines are implemented in Sweden. Scarce data from adult patients indicate an increased risk of VTE, but pediatric data is largely missing. Given the favorable overall survival of HL, there should reasonably be more focus on preventing complications. MATERIALS AND METHODS: We conducted a retrospective cohort study, including all patients registered in the Childhood Cancer Registry under the age of 18years diagnosed with HL between January 2005 and December 2015 in Sweden...
February 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28237892/increased-c-reactive-protein-levels-at-diagnosis-negatively-predict-platelet-count-recovery-after-steroid-treatment-in-newly-diagnosed-adult-immune-thrombocytopenia-patients
#18
LETTER
Y Rama Kishore, B Prashantha, M Girish, B Manaswitha
No abstract text is available yet for this article.
February 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28222322/reversal-of-dabigatran-associated-major-bleeding-with-activated-prothrombin-concentrate-a-prospective-cohort-study
#19
Sam Schulman, B Ritchie, S Nahirniak, P L Gross, M Carrier, A Majeed, H-G Hwang, M Zondag
The reversal of dabigatran-associated major bleeding can now be achieved with the antidote idarucizumab. We evaluated activated prothrombin complex concentrate (aPCC) as an alternative for this purpose. Patients treated with dabigatran and suffering a major bleed were treated as per existing hospital protocol with aPCC. They were subsequently recruited for a 30-day follow-up. Effectiveness was evaluated by the treating physician, using an Assessment Guide. Safety outcomes were arterial or venous thromboembolism or death...
February 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28222321/the-vkorc1-polymorphism-rs9923231-is-associated-with-aneurysms-of-the-ascending-aorta-in-an-austrian-population
#20
LETTER
Martin Andreas, Adelheid Panzenboeck, Shiva Shabanian, Alfred Kocher, Christine Mannhalter, Adrian Petzl, Johanna Hueblauer, Michael Wolzt, Marek Ehrlich, Irene Lang
No abstract text is available yet for this article.
February 14, 2017: Thrombosis Research
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