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Thrombosis Research

Xiao-Fang Tang, Ya-Ling Han, Jia-Hui Zhang, Jing Wang, Yi Yao, Chen He, Bo Xu, Zhan Gao, Shu-Bin Qiao, Jue Chen, Yuan Wu, Ji-Lin Chen, Run-Lin Gao, Yue-Jin Yang, Jin-Qing Yuan
INTRODUCTION: Both CYP2C19 genotyping and platelet function testing are used to predict major adverse cardiac events (MACEs) in Chinese patients treated with clopidogrel and undergoing stent implantation, but the most accurate prognostic technique is still debated. Here, we combine both techniques, to determine if a more accurate prognosis is possible. METHODS: Patients undergoing stent implantation (1104) were genotyped and assessed for platelet reactivity, with a 12-month follow-up...
October 7, 2016: Thrombosis Research
Jane Skov, Saied Ibrahim, Jørgen Jespersen
No abstract text is available yet for this article.
October 6, 2016: Thrombosis Research
Martin Ponschab, Martijn van Griensven, Stefan Heitmeier, Volker Laux, Christoph J Schlimp, Andreas Calatzis, Soheyl Bahrami, Heinz Redl, Herbert Schöchl
BACKGROUND: Platelets play a pivotal role in coagulation, inflammation and wound healing. Suitable animal models that have the potential to mimic human platelet function are limited. The objective of the current study was to compare platelet aggregation response in the whole blood of baboons and humans using impedance aggregometry. METHODS: Blood was drawn from 24 anesthetised male baboons and 25 healthy volunteers. The platelet aggregation response was determined by impedance aggregometry (Multiplate®)...
October 6, 2016: Thrombosis Research
Tina Melancon, Cory Bivona, Susan Klenke, Michelle Rockey, Jane Huh, Dave Henry, Dennis Grauer, Mazin Al-Kasspooles, Gary Johnson, Evelyn Reynolds, Julia Chapman
INTRODUCTION: Studies have shown the benefit of 28days of extended postoperative venous thromboembolism (VTE) prophylaxis for patients undergoing major cancer surgery in the abdomen or pelvis. We retrospectively evaluated the VTE incidence at the University of Kansas Hospital between gynecologic (GYN) cancer patients, who receive extended prophylaxis, and gastrointestinal (GI) cancer patients, who do not. METHODS: Patients were evaluated between January of 2010 and December of 2013, and VTE data for eligible patients were collected for 30 and 90days postoperatively...
October 6, 2016: Thrombosis Research
Ivan E B Saraiva, Paula K Miranda, Jaqueline N Freitas, Clara R A Oliveira, Thiago L B S Ataíde, Vandack Nobre, Marcus Vinícius Andrade
No abstract text is available yet for this article.
October 5, 2016: Thrombosis Research
Emma Rabinovich, John R Bartholomew, Mailey L Wilks, Barbara L Tripp, Keith R McCrae, Alok A Khorana
No abstract text is available yet for this article.
October 4, 2016: Thrombosis Research
Siavash Piran, Sam Schulman
INTRODUCTION: The true incidence of venous thromboembolism (VTE) in patients with acute spinal cord injury (SCI) is unclear. There are limited data on the risk factors associated with VTE in patients with an acute SCI. METHODS: We performed a retrospective chart review of consecutive adult patients with acute SCI. The primary outcome was incidence of symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE) within 90days. Secondary outcomes were major bleeding, all-cause mortality, and fatal PE...
October 3, 2016: Thrombosis Research
Stephen O Brennan, Andrew D Laurie, Julie-Anne Bell
No abstract text is available yet for this article.
September 30, 2016: Thrombosis Research
Priscila Corraini, Anne Gulbech Ording, Victor W Henderson, Szimonetta Szépligeti, Erzsébet Horváth-Puhó, Henrik Toft Sørensen
INTRODUCTION: The impact of cancer and other comorbidity on the risk of venous thromboembolism (VTE) after stroke is poorly understood. METHODS: We used Danish population-based national databases to conduct a cohort study encompassing 201,025 patients diagnosed with a first-time ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage or unspecified stroke between 1995 and 2012. As a comparison cohort, 983,222 members of the general population were matched to the stroke patients by date of diagnosis, year of birth, sex, and specific comorbidities, using conditions in the Charlson Comorbidity Index and other VTE risk factors...
September 29, 2016: Thrombosis Research
Takumi Aota, Hideo Wada, Naoki Fujimoto, Kazushi Sugimoto, Yoshiki Yamashita, Takeshi Matsumoto, Kohshi Ohishi, Kei Suzuki, Hiroshi Imai, Kazuo Kawasugi, Seiji Madoiwa, Hidesaku Asakura, Naoyuki Katayama
OBJECTIVE: We evaluated the modified diagnostic criteria for disseminated intravascular coagulation (DIC), which was published by the Japanese Society of Thrombosis and Hemostasis (JSTH), in 274 suspected DIC patients with hematopoietic injury. MATERIALS AND METHODS: The diagnoses of the patients were as follows: DIC (n=125); pre-DIC (n=42) and non-DIC (n=107). The efficacy of the diagnostic criteria for DIC was evaluated using a receiver operating characteristic (ROC) analysis...
September 28, 2016: Thrombosis Research
Evangelos K Oikonomou, Theodoros I Repanas, Christos Papanastasiou, Damianos G Kokkinidis, Michael Miligkos, Attila Feher, Dipti Gupta, Polydoros N Kampaktsis
BACKGROUND: In-hospital acquired thrombocytopenia (TP) is relatively common among patients hospitalized with acute coronary syndromes (ACS). However, its effect on short-term and long-term outcomes has yet to be reviewed systematically. METHODS: We conducted a systematic review and meta-analysis of clinical studies assessing the relationship between new-onset in-hospital TP and adverse outcomes among ACS patients. MEDLINE, Scopus and the Cochrane Library were searched for eligible studies published before March 20, 2016...
September 24, 2016: Thrombosis Research
Yohei Hisada, Wyeth Alexander, Raj Kasthuri, Peter Voorhees, Fariborz Mobarrez, Angela Taylor, Coleen McNamara, Hakan Wallen, MarcoWitkowski, Nigel S Key, Ursula Rauch, Nigel Mackman
No abstract text is available yet for this article.
September 24, 2016: Thrombosis Research
R Marchi, S Brennan, M E Mijares
No abstract text is available yet for this article.
September 22, 2016: Thrombosis Research
Nikesh Kawankar, Janhavi Rathi, Kanjaksha Ghosh, Shrimati Shetty
No abstract text is available yet for this article.
September 21, 2016: Thrombosis Research
Pablo Demelo-Rodríguez, Andrea Postigo-Esteban, Irene García-Fernández-Bravo, Martín Agud, Silvia Calpena, Mario Camacho, Jorge Del Toro-Cervera
OBJECTIVE: The SAMe-TT2R2 score has been recently proposed to predict the quality of anticoagulation control in patients with atrial fibrillation treated with vitamin K antagonists (VKA). We aimed at calculating this score in a cohort of patients with Venous Thromboembolism (VTE) and determine its usefulness. METHODS: We included all consecutive patients with VTE treated with VKA for >90days. We collected all variables included in the score (female sex, age<60years, medical history [>2 comorbidities], treatment [interacting drugs: e...
September 21, 2016: Thrombosis Research
Magdalena L Bochenek, Eva Schütz, Katrin Schäfer
Age is an important cardiovascular risk factor. Among others, age is associated with an increased risk to develop thrombotic cardiovascular complications, both in the arterial (acute myocardial infarction, stroke) and the venous (deep vein thrombosis, pulmonary embolism) system, which cannot be explained by the age-associated increase in cardiovascular risk factors alone. A number of studies have demonstrated that the accumulation of senescent endothelial cells and specific phenotypic and functional alterations associated with endothelial cell senescence may play an important role during the development and progression of cardiovascular disease...
September 20, 2016: Thrombosis Research
Stacy A Voils, Stephen J Lemon, Janeen Jordan, Paul Riley, Reginald Frye
: Incidence of venous thromboembolism (VTE) in adult trauma patients is high despite mechanical and pharmacologic prophylaxis. We hypothesized that thrombin formation capacity as measured by calibrated automated thrombogram (CAT) is increased early in hospitalization and is associated with the development of VTE. METHODS: We conducted a prospective study in adult, critically ill trauma patients. Plasma was generated from whole blood samples collected within the first 3days of hospital admission...
September 20, 2016: Thrombosis Research
Monica Attanasio, Rossella Marcucci, Anna Maria Gori, Rita Paniccia, Serafina Valente, Daniela Balzi, Alessandro Barchielli, Nazario Carrabba, Renato Valenti, David Antoniucci, Rosanna Abbate, Gian Franco Gensini
INTRODUCTION: Thrombin generation (TG) is a central step of the coagulation system involved in hemostatic and thrombotic roles. Scarce data evaluating in the acute phase the association between TG and the risk of cardiovascular death of acute coronary syndrome (ACS) patients are available, in the era of percutaneous coronary intervention (PCI) and stenting with the use of dual antiplatelet treatment. MATERIALS AND METHODS: We investigated TG in 292 ACS patients undergoing PCI with stent implantation on dual antiplatelet treatment...
September 19, 2016: Thrombosis Research
Shunsuke Tawara, Takumi Sakai, Osamu Matsuzaki
BACKGROUND: Thrombomodulin (TM) alfa, a recombinant human soluble TM, enhances activation of pro-carboxypeptidase B2 (pro-CPB2) by thrombin. Activated pro-CPB2 (CPB2) exerts anti-inflammatory and anti-fibrinolytic activities. Therefore, TM alfa may also have anti-inflammatory and anti-fibrinolytic effects through CPB2. However, these effects of TM alfa have not been elucidated. In the present study, we investigated the effects of TM alfa on inactivation of complement component C5a as an anti-inflammatory effect and prolongation of clot lysis time as an anti-fibrinolytic effect via CPB2 in vitro...
September 17, 2016: Thrombosis Research
S M Bleker, L F M Beenen, M Di Nisio, N van Es, H R Büller, N Kraaijpoel, A Rutten
BACKGROUND: The incidence of incidental pulmonary embolism (IPE) in cancer patients is increasing. There is scant information on the interobserver agreement among radiologists about the diagnosis of distal incidental clots and the actual radiologic extension of IPE. METHODS: A total of 88 contrast-enhanced computed tomography (CT) scans of cancer patients with IPE were reassessed blindly by two expert thoracic radiologists. First, 62 scans were reassessed and the interobserver agreement on most proximal extent of IPE was calculated between the two expert radiologists as well as between the initial and expert reading, using the kappa statistic...
September 17, 2016: Thrombosis Research
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