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Thrombosis Research

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https://www.readbyqxmd.com/read/28222322/reversal-of-dabigatran-associated-major-bleeding-with-activated-prothrombin-concentrate-a-prospective-cohort-study
#1
Sam Schulman, B Ritchie, S Nahirniak, P L Gross, M Carrier, A Majeed, H-G Hwang, M Zondag
The reversal of dabigatran-associated major bleeding can now be achieved with the antidote idarucizumab. We evaluated activated prothrombin complex concentrate (aPCC) as an alternative for this purpose. Patients treated with dabigatran and suffering a major bleed were treated as per existing hospital protocol with aPCC. They were subsequently recruited for a 30-day follow-up. Effectiveness was evaluated by the treating physician, using an Assessment Guide. Safety outcomes were arterial or venous thromboembolism or death...
February 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28222321/the-vkorc1-polymorphism-rs9923231-is-associated-with-aneurysms-of-the-ascending-aorta-in-an-austrian-population
#2
LETTER
Martin Andreas, Adelheid Panzenboeck, Shiva Shabanian, Alfred Kocher, Christine Mannhalter, Adrian Petzl, Johanna Hueblauer, Michael Wolzt, Marek Ehrlich, Irene Lang
No abstract text is available yet for this article.
February 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28219844/parameters-of-complete-blood-count-do-not-predict-on-treatment-platelet-reactivity-in-acute-coronary-syndrome-patients
#3
LETTER
Laurent Bonello, Marc Laine, Véronique Baccini, Corinne Frere
No abstract text is available yet for this article.
February 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28226257/performance-of-the-age-adjusted-cut-off-for-d-dimer-in-patients-with-cancer-and-suspected-pulmonary-embolism
#4
LETTER
I T Wilts, G Le Gal, P L Den Exter, J Van Es, M Carrier, B Planquette, H R Büller, M Righini, M V Huisman, P W Kamphuisen
BACKGROUND: Cancer patients frequently present with suspected pulmonary embolism (PE). The D-dimer (DD) test is less useful in excluding PE in cancer patients due to the lower specificity. In the general population, the age-adjusted cutoff for DD combined with a clinical decision rule (CDR) improved specificity in the diagnosis of PE. OBJECTIVES: To evaluate the safety and efficacy of the age-adjusted cutoff (defined as age∗10μg/L in patients >50years) combined with a CDR for the exclusion of PE in cancer patients...
February 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28213102/comparison-of-multiplate-and-verifynow-platelet-function-tests-in-predicting-clinical-outcome-in-patients-with-acute-coronary-syndromes
#5
Peter D Larsen, Ana S Holley, Alexander Sasse, Ali Al-Sinan, Sarah Fairley, Scott A Harding
INTRODUCTION: This study examined the ability of two widely used "point of care" platelet function assays, VerifyNow and Multiplate, to predict adverse outcomes in patients with acute coronary syndromes (ACS). METHODS: We examined platelet reactivity using VerifyNow and Multiplate P2Y12 assays in patients with ACS and the relationship between platelet reactivity and both MACE (defined as a composite of death, myocardial infarction, stroke, stent thrombosis and unplanned revascularisation) and TIMI major bleeding at 1year...
February 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28208084/hypomethylation-of-tissue-factor-pathway-inhibitor-2-in-human-placenta-of-preeclampsia
#6
Xirong Xiao, Xiang Tao, Yongxiang Wang, Lisha Zhu, Yunzhen Ye, Haiyan Liu, Qiongjie Zhou, Xiaotian Li, Yu Xiong
OBJECTIVES: To investigate the expression, DNA methylation status and its regulatory mechanism of tissue factor pathway inhibitor 2 (TFPI-2) in human placenta tissues of preeclampsia (PE). MATERIAL AND METHODS: We studied the mRNA and protein expression and the promoter methylation levels of TFPI-2 in the PE placentas compared with those in the normal pregnant (NP) women. Quantitative real-time polymerase chain reaction, immunohistochemistry, western blot, and Sequenom MassARRAY were used for placenta tissue detection...
February 8, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28192715/rivaroxaban-shows-promise-as-effective-therapy-for-cancer-patients-with-venous-thromboembolic-disease
#7
LETTER
I Theberge, J Bowdridge, M A Forgie, M Carrier, M Louzada, L Siquiera, M Rhodes, P S Wells
No abstract text is available yet for this article.
February 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28189910/high-prevalence-of-mental-disorders-in-patients-with-inherited-protein-s-deficiency-a-case-report-series
#8
LETTER
Silvia Hoirisch-Clapauch, Antonio E Nardi
No abstract text is available yet for this article.
February 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28219843/the-impact-of-the-endothelial-protein-c-receptor-on-thrombin-generation-and-clot-lysis
#9
Laura Pepler, Chengliang Wu, Dhruva J Dwivedi, Cynthia Wu, Paul Y Kim, Patricia C Liaw
INTRODUCTION: When thrombin is bound to thrombomodulin (TM), it becomes a potent activator of protein C (PC) and thrombin-activable fibrinolysis inhibitor (TAFI). Activation of PC is enhanced when PC is bound to the endothelial protein C receptor (EPCR). Activated protein C (APC) inhibits thrombin generation while activated TAFI (TAFIa) attenuates fibrinolysis. To determine the impact of diminished EPCR function on thrombin generation and fibrinolysis we generated cells that expressed TM and a variant of EPCR (R96C) that does not bind PC...
February 3, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28167400/postpartum-atypical-hemolytic-uremic-syndrome-with-complement-factor-h-mutation-complicated-by-reversible-cerebrovascular-constriction-syndrome-successfully-treated-with-eculizumab
#10
LETTER
Makoto Yamaguchi, Mayuko Hori, Nagaya Hiroshi, Shoichi Maruyama
No abstract text is available yet for this article.
February 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28213103/expression-and-characterization-of-haemathrins-madanin-like-thrombin-inhibitors-isolated-from-the-salivary-gland-of-tick-haemaphysalis-bispinosa-acari-ixodidae
#11
Rajeev Kungur Brahma, Guillaume Blanchet, Simran Kaur, R Manjunatha Kini, Robin Doley
Saliva of hematophagous animals, such as ticks, is an excellent source of anticoagulant proteins and polypeptides. Here we describe the identification and characterization of two thrombin inhibitors named as haemathrin 1 and 2 from the salivary gland of tick Haemaphysalis bispinosa using genomic approach. Haemathrins are cysteine-less peptide anticoagulants, which share about 65-70% identity with madanins, and belong to inhibitor I53 superfamily of inhibitors of the MEROPS database. Haemathrins were overexpressed in E...
January 31, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28160671/platelet-reactivity-in-patients-carrying-the-e-nos-g894t-polymorphism-after-a-loading-dose-of-aspirin-plus-clopidogrel
#12
LETTER
Teresa Strisciuglio, Giuseppe Di Gioia, Fabio Mangiacapra, Chiara De Biase, Leen Delrue, Mariano Pellicano, Jozef Bartunek, Marc Vanderheyden, Raffaele Izzo, Bruno Trimarco, William Wijns, Emanuele Barbato
No abstract text is available yet for this article.
January 27, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28139259/dalteparin-thromboprophylaxis-in-cancer-patients-at-high-risk-for-venous-thromboembolism-a-randomized-trial
#13
Alok A Khorana, Charles W Francis, Nicole M Kuderer, Marc Carrier, Thomas L Ortel, Ted Wun, Deborah Rubens, Susan Hobbs, Renuka Iyer, Derick Peterson, Andrea Baran, Katherine Kaproth-Joslin, Gary H Lyman
BACKGROUND: Ambulatory cancer patients at high-risk for venous thromboembolism (VTE) can be identified using a validated risk score (Khorana score). We evaluated the benefit of outpatient thromboprophylaxis with dalteparin in high-risk patients in a multicenter randomized study. METHODS: Cancer patients with Khorana score≥3 starting a new systemic regimen were screened for VTE and if negative randomized to dalteparin 5000units daily or observation for 12weeks...
January 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28161616/hospitalization-with-infection-and-incident-venous-thromboembolism-the-aric-study
#14
Logan T Cowan, Pamela L Lutsey, James S Pankow, Mary Cushman, Aaron R Folsom
BACKGROUND AND OBJECTIVES: Acute triggers for VTE, which may include infection, are understudied, as is the timing and duration of VTE risk after infection. We hypothesized that there is an association between hospitalization with infection and short-term VTE risk that exceeds the known association between hospitalization and VTE. METHODS: VTE cases and infections were identified in the Atherosclerosis Risk in Communities (ARIC) cohort. A case-crossover design and conditional logistic regression were used to compare hospitalized infections among VTE cases (14, 30, 42, and 90days before VTE) with corresponding control periods 1year and 2years prior...
January 25, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28160670/cost-effectiveness-of-the-addition-of-a-comprehensive-ct-scan-to-the-abdomen-and-pelvis-for-the-detection-of-cancer-after-unprovoked-venous-thromboembolism
#15
Kathryn Coyle, Marc Carrier, Alejandro Lazo-Langner, Sudeep Shivakumar, Ryan Zarychanski, Vicky Tagalakis, Susan Solymoss, Nathalie Routhier, James Douketis, Douglas Coyle
IMPORTANCE: Unprovoked venous thromboembolism (VTE) can be the first manifestation of cancer. It is unclear if extensive screening for occult cancer including a comprehensive computed tomography (CT) scan of the abdomen/pelvis is cost-effective in this patient population. OBJECTIVE: To assess the health care related costs, number of missed cancer cases and health related utility values of a limited screening strategy with and without the addition of a comprehensive CT scan of the abdomen/pelvis and to identify to what extent testing should be done in these circumstances to allow early detection of occult cancers...
January 25, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28152437/platelet-function-as-a-risk-factor-for-venous-thromboembolism-in-the-framingham-heart-study
#16
Marja K Puurunen, Shih-Jen Hwang, Chris J O'Donnell, Geoffrey Tofler, Andrew D Johnson
INTRODUCTION: The relationship of venous thromboembolism (VTE) with platelet reactivity is unclear. Platelet function plays a key role in arterial thrombosis. Evidence suggests antiplatelet agents also effects in reducing VTE. Our aim is to describe the role of baseline platelet function in development of VTE in the community-based Framingham Heart Study (FHS) cohort. MATERIALS AND METHODS: Participants in the Framingham Offspring cohort fifth examination and Omni cohort first examination were eligible...
January 25, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28157564/global-impairments-in-the-haemostasis-systems-after-cardiopulmonary-bypass
#17
LETTER
Shu He, Margareta Blombäck, Håkan Wallén, Anders Jeppsson, Stefan Grass
No abstract text is available yet for this article.
January 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28109976/a-novel-ankrd26-gene-variant-causing-inherited-thrombocytopenia-in-a-family-of-finnish-origin-another-brick-in-the-wall
#18
LETTER
M Averina, H Jensvoll, H Strand, M Sovershaev
No abstract text is available yet for this article.
January 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28092799/fibrin-improves-skin-wound-perfusion-in-a-diabetic-rat-model
#19
Tamara Hoppenbrouwers, Bastiaan Tuk, Esther M G Fijneman, Moniek P M de Maat, Johan W van Neck
: The fibrin matrix of the thrombus that is formed directly after wounding, is an important determinant of the success of the early phase of wound healing. This phase is often impaired in patients with diabetes. A promising approach to improve skin wound healing is the application of a pro-angiogenic fibrin matrix onto the wound. We studied this in 59 female WAG/RijCrl diabetic rats, in which we created two dorsal full-thickness wounds of which one was treated with a human physiological fibrin matrix (2mg/ml) and one with PBS as control...
January 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28088607/transcatheter-aortic-valve-implantation-leads-to-a-restoration-of-von-willebrand-factor-vwf-abnormalities-in-patients-with-severe-aortic-stenosis-incidence-and-relevance-of-clinical-and-subclinical-vwf-dysfunction-in-patients-undergoing-transfemoral-tavi
#20
Alexander Sedaghat, Hannah Kulka, Jan-Malte Sinning, Nora Falkenberg, Julia Driesen, Barbara Preisler, Christoph Hammerstingl, Georg Nickenig, Bernd Pötzsch, Johannes Oldenburg, Hans-Jörg Hertfelder, Nikos Werner
BACKGROUND: In this study, we sought to analyze the incidence and relevance of von Willebrand factor (VWF) abnormalities in patients undergoing transcatheter aortic valve implantation (TAVI), especially on perioperative bleeding. Furthermore, we hypothesized that, similar to aortic valve surgery, TAVI results in a restoration of VWF abnormalities. METHODS AND RESULTS: We performed a prospective analysis of periinterventional VWF parameters in 74 patients (80±7years, female in 37...
January 7, 2017: Thrombosis Research
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