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Thrombosis Research

Nikolaos Spinthakis, Mohamed Farag, Ying X Gue, Manivannan Srinivasan, David M Wellsted, Diana A Gorog
Although used routinely to reduce thrombotic events in patients with coronary disease, the effects of P2Y12 inhibitors on thrombus stability and endogenous fibrinolysis are largely unknown. Blood taken from patients pre- and post-aspirin (n = 20) and on aspirin alone and on dual antiplatelet therapy comprising aspirin plus clopidogrel (n = 20), ticagrelor (n = 20) or cangrelor (n = 20), was tested using the Global Thrombosis Test. The number of "rebleeds" or drops (D) after early platelet-rich thrombus formation (occlusion time, OT), and before final lasting occlusion, was used as an inverse measure of thrombus stability...
November 24, 2018: Thrombosis Research
Jinwei Xie, Qinsheng Hu, Zeyu Huang, Zongke Zhou, Fuxing Pei
INTRODUCTION: The ideal route for the administration of tranexamic acid (TXA) remains undecided. This study aimed to compare the efficacy and safety of three routes of TXA following primary total knee arthroplasty (TKA). MATERIALS AND METHODS: We prospectively collected patients' data through the National Health Database from January 2013 to September 2017. The patients were divided into a control group, intravenous group, topical group, and combined group according to the different routes of TXA...
November 23, 2018: Thrombosis Research
Boriana Guimicheva, Jignesh P Patel, Lara N Roberts, Devi Subramanian, Roopen Arya
INTRODUCTION: Based on current guidelines, many women qualify for postnatal thromboprophylaxis following childbirth, however, little information exists on how adherent women are and their experiences to both pharmacological and mechanical forms of thromboprophylaxis. MATERIALS AND METHODS: Women requiring postnatal thromboprophylaxis were given questionnaire packs exploring their beliefs about enoxaparin, anti-embolic stockings (AES) and intermittent pneumatic compression devices (IPCD)...
November 22, 2018: Thrombosis Research
Joanna Y Huang, Vera Ignjatovic, Bennett J Sheridan, Jacob Mathew, Yves D'Udekem, Johann Brink, Rebecca Barton, Gabrielle Callea, Dominique Morsman, Susan Donath, Stephen Opat, Paul Monagle
INTRODUCTION: Durable Ventricular Assist Devices (VADs) are increasingly used in children with end-stage heart failure. Major complications are bleeding and thromboembolism (TE). Our objective was to determine the timing, incidence and risk factors for bleeding and TE in children implanted with VADs. METHODS: This was a retrospective cohort of 8 years experience for children implanted with HeartWare HVAD and Berlin Heart EXCOR VADs at the Royal Children's Hospital, Melbourne...
November 22, 2018: Thrombosis Research
Fahrettin Covut, Tariq Kewan, Oscar Perez, Monica Flores, Abdo Haddad, Hamed Daw
No abstract text is available yet for this article.
November 20, 2018: Thrombosis Research
Shahrzad Salmasi, Leanne Kwan, Jenny MacGillivray, Nick Bansback, Mary A De Vera, Arden R Barry, Mark J Harrison, Jason Andrade, Larry D Lynd, Peter Loewen
INTRODUCTION: Patients' lack of knowledge is a key barrier to therapy adherence. We aimed to gather insights into atrial fibrillation (AF) patients' education needs from patient and clinician viewpoints. METHODS: We conducted a qualitative descriptive study using purposive sampling and semi-structured interviews with AF patients and clinicians recruited from AF clinics. Data from patients and clinicians were analyzed independently and iteratively through inductive qualitative thematic analysis...
November 16, 2018: Thrombosis Research
Anna Hau, Eric Wegener, Vera Ignjatovic, Shoshana Revel-Vilk, Paul Monagle
Positive family history is known to be an independent risk factor for venous thromboembolic (VTE) that may or may not reflect an underlying hereditary disorder. However, there is no clear standardized definition of what constitutes a positive family history for VTE in children. We aimed to assess the current published definitions of positive family history as a risk factor for VTE in children and ascertain if any consensus exists. METHODS: We conducted a literature review through two major databases PUBMED and EMBASE (1969-June 2018)...
November 16, 2018: Thrombosis Research
Azusa Nagao, Cindy H T Yeung, Federico Germini, Takashi Suzuki
INTRODUCTION: Standard prophylaxis dosing based on bodyweight may result in over- or under-dosing due to interpatient variability. Adopting individual pharmacokinetic (PK) based tailoring may improve adherence to treatment guideline, and consequently clinical outcomes. Here we report clinical observations performed across the adoption of individual PK based tailoring in a single center in Japan. METHODS: An individual PK study on sparse samples was modeled on myPKFiT or WAPPS-Hemo, depending on concentrate, and used to optimize treatment regimens...
November 16, 2018: Thrombosis Research
W E Dager, A J Roberts, D K Nishijima
OBJECTIVE: Management of acute, major or life threatening bleeding in the presence of direct acting oral anticoagulants (DOAC) is unclear. In the absence of a specific antidote, or in situations where there is a need for adjunctive therapy, the ideal prothrombin complex concentrate and dose is unclear. The goal of our study was to evaluate the outcomes of our reduced dosing strategy with FEIBA in patients experiencing a DOAC-related bleeding event. DESIGN: Retrospective analysis of patients treated with FEIBA for a DOAC-related bleeding event...
November 16, 2018: Thrombosis Research
Naoki Kurita, Tatsuhiro Sakamoto, Takayasu Kato, Manabu Kusakabe, Yasuhisa Yokoyama, Hidekazu Nishikii, Mamiko Sakata-Yanagimoto, Naoshi Obara, Yuichi Hasegawa, Shigeru Chiba
INTRODUCTION: Disseminated intravascular coagulation (DIC) is a lethal complication in patients with hematologic malignancies (HMs). DIC can be induced by the HM itself, but also by HM-associated secondary infection; however, whether difference of triggering factor impacts the outcome of DIC in HM patients remains unknown. The objective of this study is to clarify the difference between HM-induced DIC and infection-induced DIC in HM patients regarding treatment response and prognosis...
November 16, 2018: Thrombosis Research
Mao Li, Qiang Guo, Weiming Hu
BACKGROUND: The risk and prognosis of VTE associated with oncologic surgery need to be quantified to guide patient management. We aimed to examine the availability of data and to report the incidence of venous thromboembolism (VTE) in cancer patients after surgery, as well as the clinical outcomes of VTE following oncologic surgery. METHODS: We searched multiple databases for terms related to VTE after oncologic surgery from inception to November 1, 2017. A random-effects meta-analysis was done to calculate the pooled incidence of VTE...
November 16, 2018: Thrombosis Research
Zhiyan Liu, Qian Xiang, Xia Zhao, Zining Wang, Guangyan Mu, Qiufen Xie, Shuang Zhou, Shuqing Chen, Kun Hu, Junyu Xu, Lingyue Ma, Yimin Cui
AIM: We aimed to investigate the genetic polymorphisms and pharmacogenetic variability associated with the pharmacodynamics (PD) and pharmacokinetics (PK) of prasugrel, in healthy Han Chinese subjects. PATIENTS & METHODS: Healthy, native, Han Chinese subjects (n = 36) aged 18 to 45 years with unknown genotypes were included. All subjects received a loading dose (LD) on day 1 and a maintenance dose (MD) from day 2 until day 11. Candidate gene association and gene-set analysis of biological pathways related to prasugrel and platelet activity were analyzed...
November 15, 2018: Thrombosis Research
Heng Mei, Ying Jiang, Lili Luo, Ruibin Huang, Lei Su, Ming Hou, Xuefeng Wang, Jun Deng, Yu Hu
BACKGROUND: Accurate and early diagnosis is important in the management of disseminated intravascular coagulation (DIC). We employed new automation technology to detect plasma biomarkers, including thrombin-antithrombin complex (TAT), α2-plasmininhibitor-plasmin complex (PIC), soluble thrombomodulin (sTM), and tissue plasminogen activator-inhibitor complex (tPAIC), and evaluated their diagnostic performance and prognostic value for DIC in Chinese population. METHODS: This prospective observational study included 444 patients with suspected DIC and 137 healthy people...
November 13, 2018: Thrombosis Research
Irene Di Pasquale, Ulrich Budde, Francesco Tona, Antonella Bertomoro, Anna Maria Lombardi, Giulia Famoso, Irene Bertozzi, Rita Dittmer, Sonja Schneppenheim, Fabrizio Fabris
INTRODUCTION: ADAMTS13 deficiency results in unusually large von Willebrand factor (ULVWF) multimers in the circulation and a higher risk of microthrombi due to high shear stress. In patients treated for acquired thrombotic thrombocytopenic purpura (TTP), a persistently severe ADAMTS13 deficiency (<10%) in remission is associated with more relapses. A reduced plasma ADAMTS13 activity and increased VWF levels are associated with a higher risk of myocardial infarction. Assessing coronary flow reserve (CFR) enables a better cardiovascular risk stratification: a lower CFR correlates inversely with cardiovascular risk...
November 12, 2018: Thrombosis Research
V Pengo, T Del Ross, A Ruffatti, E Bison, M G Cattini, E Pontara, S Testa, C Legnani, N Pozzi, D Peterle, L Acquasaliente, V De Filippis, G Denas
BACKGROUND: Whether antibodies directed to β2-Glycoprotein I (aβ2GPI) are responsible for LA activity is not well defined. However, in the absence of such antibodies the molecule responsible for LA phenomenon is unknown. OBJECTIVE: The aim of this study was the biochemical identification of the target antigen epitope of aPL responsible of LA activity in the absence of aβ2GPI antibodies together with the biological and clinical characteristics of these patients in comparison with classical triple positive patients...
November 9, 2018: Thrombosis Research
Mattia Ferrarese, Silvia Pignani, Silvia Lombardi, Dario Balestra, Francesco Bernardi, Mirko Pinotti, Alessio Branchini
Fusion with human serum albumin (HSA), which represents a well-established technique to extend half-life of therapeutic proteins, commonly exploits intervening peptide linkers as key components. Here, we explored the human coagulation factor X (FX) carboxyl-terminal region, previously demonstrated by us to be dispensable for secretion and coagulant activity, as a natural linker for fusion purposes. To test our hypothesis, we compared direct FX-HSA fusion with the designed FX-HSA fusion proteins mimicking the recombinant activated factor VII (rFVIIa)-HSA or factor IX (FIX)-HSA chimeras, both strongly dependent from artificial linkers...
November 9, 2018: Thrombosis Research
Danijela Mikovic, Iva Pruner, Jovan P Antovic, Roza Chaireti
No abstract text is available yet for this article.
November 8, 2018: Thrombosis Research
G C Mol, C E A Dronkers, M A van de Ree, S L van der Pas, M J A M Tegelberg-Stassen, F B M Sanders, S Koppen, O de Weerdt, T Koster, M M C Hovens, H A H Kaasjager, R E Brouwer, E Kragten, C G Schaar, W Spiering, W P Arnold, M V Huisman, F A Klok
BACKGROUND: Elastic compression stockings (ECS) are uncomfortable to wear but may prevent post-thrombotic syndrome (PTS). The ability to predict PTS may help clinical decision making regarding the optimal duration of ECS after deep vein thrombosis (DVT). AIMS: Predefined endpoint analysis of the Octavia study that randomized patients who compliantly used ECS up to one year after DVT to continue or discontinue ECS treatment. Primary aim was to identify predictors of PTS...
November 7, 2018: Thrombosis Research
Mirjana Kovac, Gorana Mitic, Zeljko Mikovic, Vesna Mandic, Predrag Miljic, Mirjana Mitrovic, Branko Tomic, Zsuzsanna Bereczky
BACKGROUND: Inherited antithrombin (AT) deficiency is a rare autosomal dominant disorder, caused by mutations in the SERPINC1 gene. The most common clinical presentation in AT deficient patients includes venous thrombosis and pulmonary embolism, while the association of AT deficiency and its effect on the development of pregnancy complications has been less studied. The aim of our research was to evaluate the effect of AT deficiency types, determined by genotyping, on pregnancy outcomes...
November 7, 2018: Thrombosis Research
Simon Noble
No abstract text is available yet for this article.
November 6, 2018: Thrombosis Research
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