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Thrombosis Research

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https://www.readbyqxmd.com/read/28109976/a-novel-ankrd26-gene-variant-causing-inherited-thrombocytopenia-in-a-family-of-finnish-origin-another-brick-in-the-wall
#1
LETTER
M Averina, H Jensvoll, H Strand, M Sovershaev
No abstract text is available yet for this article.
January 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28092799/fibrin-improves-skin-wound-perfusion-in-a-diabetic-rat-model
#2
Tamara Hoppenbrouwers, Bastiaan Tuk, Esther M G Fijneman, Moniek P M de Maat, Johan W van Neck
: The fibrin matrix of the thrombus that is formed directly after wounding, is an important determinant of the success of the early phase of wound healing. This phase is often impaired in patients with diabetes. A promising approach to improve skin wound healing is the application of a pro-angiogenic fibrin matrix onto the wound. We studied this in 59 female WAG/RijCrl diabetic rats, in which we created two dorsal full-thickness wounds of which one was treated with a human physiological fibrin matrix (2mg/ml) and one with PBS as control...
January 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28088607/transcatheter-aortic-valve-implantation-leads-to-a-restoration-of-von-willebrand-factor-vwf-abnormalities-in-patients-with-severe-aortic-stenosis-incidence-and-relevance-of-clinical-and-subclinical-vwf-dysfunction-in-patients-undergoing-transfemoral-tavi
#3
Alexander Sedaghat, Hannah Kulka, Jan-Malte Sinning, Nora Falkenberg, Julia Driesen, Barbara Preisler, Christoph Hammerstingl, Georg Nickenig, Bernd Pötzsch, Johannes Oldenburg, Hans-Jörg Hertfelder, Nikos Werner
BACKGROUND: In this study, we sought to analyze the incidence and relevance of von Willebrand factor (VWF) abnormalities in patients undergoing transcatheter aortic valve implantation (TAVI), especially on perioperative bleeding. Furthermore, we hypothesized that, similar to aortic valve surgery, TAVI results in a restoration of VWF abnormalities. METHODS AND RESULTS: We performed a prospective analysis of periinterventional VWF parameters in 74 patients (80±7years, female in 37...
January 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28092798/acute-kidney-injury-and-risk-of-deep-vein-thrombosis-and-pulmonary-embolism-in-taiwan-a-nationwide-retrospective-cohort-study
#4
Tsung-Hang Kuo, Hsin-Yang Li, Sheng-Hsiang Lin
INTRODUCTION: Chronic kidney disease (CKD) increases risk for deep vein thrombosis (DVT) and pulmonary embolism (PE). However, few studies have investigated the relationship between acute kidney injury (AKI) and risk of DVT and PE. Therefore, we conducted a nationwide longitudinal cohort study to determine whether patients with AKI are associated with increased risk of developing DVT and PE. METHODS: We included >30years-old inpatients (n=4734) receiving the diagnosis of AKI from 2000 to 2006 and their age-and sex-matched non-AKI inpatients using medical service in the same year (n=47...
January 6, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28073030/to-screen-or-not-to-screen-for-chronic-thromboembolic-pulmonary-hypertension-after-acute-pulmonary-embolism
#5
REVIEW
Yvonne M Ende-Verhaar, Menno V Huisman, Frederikus A Klok
Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli from the pulmonary arteries. Early CTEPH diagnosis may improve surgical possibilities and patients outcome. Currently, early diagnosis of CTEPH is a major challenge as demonstrated by an unacceptable median diagnostic delay of over a year and as a result, surgery is impossible in 40% of patients...
January 5, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28088606/choice-of-factor-viii-ix-regimen-in-adolescents-and-young-adults-with-severe-or-moderately-severe-haemophilia-a-french-national-observational-study-orthem-15-25
#6
Sandrine Meunier, Roseline d'oiron, Hervé Chambost, Edita Dolimier, Benoît Guillet
INTRODUCTION: The value and challenges of long-term prophylaxis (LTP) in adolescents and young adults need further characterisation. AIM: To determine the proportions of adolescents and young adults with severe or moderately severe haemophilia in France under LTP and treatment on demand (OD). METHODS: Patients 15 to 25years old with haemophilia A or B, factor VIII/IX ≤2% and no current inhibitor could be included if they had been under factor VIII/IX treatment at least 12months and kept a treatment and bleeding diary...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28068529/impact-of-high-dose-statins-on-vitamin-d-levels-and-platelet-function-in-patients-with-coronary-artery-disease
#7
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Matteo Nardin, Alon Schaffer, Lucia Barbieri, Veronica Daffara, Paolo Marino, Giorgio Bellomo, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Statins represent a pivotal treatment in coronary artery disease, offering a reduction in cardiovascular risk even beyond their lipid-lowering action. However, the mechanism of these "pleiotropic" benefits of statins is poorly understood. Vitamin D has been suggested as a potential mediator of the anti-inflammatory, anti-thrombotic and vascular protecting effects of statins. Aim of present study was to assess the impact of a high-intensity statin therapy on vitamin D levels and platelet function in patients with coronary artery disease...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28043043/seasonal-variation-of-pulmonary-embolism-and-age-dependence
#8
EDITORIAL
Bengt Zöller, Xinjun Li, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
No abstract text is available yet for this article.
December 27, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28043042/response-of-prothrombin-time-to-rivaroxaban-in-japanese-patients-with-non-valvular-atrial-fibrillation-characteristics-of-5-representative-reagents-in-japan-cvi-aro-1
#9
LETTER
Shinya Suzuki, Takeshi Yamashita, Hidefumi Kasai, Takayuki Otsuka, Koichi Sagara
No abstract text is available yet for this article.
December 27, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28088608/gene-analysis-of-six-cases-of-congenital-protein-s-deficiency-and-functional-analysis-of-protein-s-mutations-a139v-c449f-r451q-c475f-a525v-and-d599tfster13
#10
Fumina Taniguchi, Eriko Morishita, Akiko Sekiya, Haruka Nomoto, Shiori Katsu, Shounosuke Kaneko, Hidesaku Asakura, Shigeki Ohtake
Congenital deficiency of protein S (PS), an anticoagulant factor, leads to venous thrombosis, with onset predominantly beginning in adolescence. In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital PS deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13)...
December 24, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28043040/rho-kinase-inhibitor-treatment-prevents-pulmonary-inflammation-and-coagulation-in-lipopolysaccharide-induced-lung-injury
#11
Renyu Ding, Dongmei Zhao, Xiaoxia Li, Baoyan Liu, Xiaochun Ma
INTRODUCTION: In the pathogenesis of sepsis-induced acute lung injury (ALI), the crosstalk between inflammation and coagulation plays a pivotal role. The aim of this study was to investigate the role of Rho kinase (ROCK) inhibitor in alleviating pulmonary inflammation and coagulation in lipopolysaccharide (LPS)-induced acute lung injury (ALI) models. METHODS: In the in vivo study, mice were randomized to four different groups: Control, Y-27632 (Y), LPS, and LPS+Y-27632 (LPS+Y)...
December 24, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28043041/detection-of-tissue-factor-positive-extracellular-vesicles-by-laser-scanning-confocal-microscopy
#12
Yohei Hisada, Alyson C Auriemma, Wyeth Alexander, Cihan Ay, Nigel Mackman
INTRODUCTION: Increased levels of tissue factor-positive extracellular vesicles (TF+EVs) have been detected in the plasma of patients with various diseases, including cancer and endotoxemia. Levels of TF+EVs in plasma samples can be measured by antigen and activity assays. The aim of the present study was to visualize TF+EVs by laser scanning confocal microscopy (LSCM). METHODS: EVs were isolated from the supernatant of two cultured human pancreatic cancer cell lines (Panc-1 and BxPc-3), from untreated or lipopolysaccharide (LPS) treated whole blood, and from plasma of pancreatic cancer patients...
December 23, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28064037/comparative-effectiveness-and-safety-of-direct-oral-anticoagulants-doacs-versus-conventional-anticoagulation-for-the-treatment-of-cancer-related-venous-thromboembolism-a-retrospective-analysis
#13
LETTER
Jeremy A Ross, Marilyn M Miller, Cristhiam M Rojas Hernandez
PURPOSE: The standard of care for the treatment of cancer-related venous thromboembolism (VTE) is a low molecular weight heparin (LMWH) formulation. The recent development of direct oral anticoagulants (DOACs) and their approval for the treatment of VTE has resulted in several new options for treatment. If equivalent to LMWH in terms of safety and effectiveness, the use of DOACs in the treatment of cancer-related VTE would reduce the risk of VTE recurrence while potentially improving the quality of life of many cancer patients...
December 22, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28039844/low-molecular-weight-heparin-versus-vitamin-k-antagonists-for-the-treatment-of-cancer-associated-thrombosis-a-cost-effectiveness-analysis
#14
Nathan T Connell, Gregory A Abel, Jean M Connors
INTRODUCTION: Cancer-associated venous thromboembolism (VTE) is primarily treated with low-molecular weight heparin (LMWH), a strategy based on studies showing it to be superior to the vitamin K antagonist (VKA) warfarin for preventing VTE recurrence. Subsequent analyses suggest that the magnitude of this benefit might be less than previously determined. Neither patient-focused measures of utility nor the costs of each strategy have been evaluated in the current treatment era. METHODS: This is a cost-effectiveness analysis of VKA and LMWH for the treatment of cancer-associated thrombosis through use of a microsimulation model of outcomes for competing anticoagulation management strategies from a 2014 United States societal perspective...
December 22, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28024652/patient-engagement-in-research-are-we-really-worse-than-orthopaedics
#15
EDITORIAL
Simon Noble
No abstract text is available yet for this article.
December 22, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28012566/new-evidence-on-old-drugs-warfarin-versus-aspirin-after-bioprosthetic-aortic-valve-placement
#16
EDITORIAL
Scott M Stevens, John R Doty
No abstract text is available yet for this article.
December 20, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28002757/the-khorana-score-for-the-prediction-of-venous-thromboembolism-in-patients-with-pancreatic-cancer
#17
LETTER
N van Es, V F Franke, S Middeldorp, J W Wilmink, H R Büller
BACKGROUND: The Khorana score is a clinical prediction score developed to identify ambulatory cancer patients at high risk of venous thromboembolism (VTE), who may be eligible for thromboprophylaxis. This score has been validated in various populations with cancer, but its performance in patients with pancreatic cancer is less clear. PATIENTS AND METHODS: This is a single center, retrospective cohort study in which consecutive, ambulatory patients with pancreatic adenocarcinoma, who started neoadjuvant or palliative chemotherapy at our center between 2003 and 2014 were included...
December 16, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28024182/calr-exon-9-mutations-in-idiopathic-splanchnic-vein-thrombosis-in-an-australian-cohort
#18
LETTER
Wai Khoon Ho, Frank S Hong
No abstract text is available yet for this article.
December 15, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28007401/increasing-the-methodological-quality-and-relevance-of-cost-effectiveness-analysis
#19
EDITORIAL
Doug Coyle
No abstract text is available yet for this article.
December 15, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28012359/changes-of-in-vitro-potency-of-anticoagulant-drugs-are-similar-between-patients-with-cirrhosis-due-to-alcohol-or-non-alcoholic-fatty-liver-disease
#20
LETTER
Sarah Bos, Wilma Potze, Mohammad S Siddiqui, Sherry L Boyett, Jelle Adelmeijer, Kalyani Daita, Ton Lisman, Arun J Sanyal
No abstract text is available yet for this article.
December 14, 2016: Thrombosis Research
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