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Thrombosis Research

Anette Tarp Hansen, Puk Sandager, Mette Ramsing, Olav B Petersen, Jannie D Salvig, Svend Juul, Niels Uldbjerg, Anne-Mette Hvas
OBJECTIVE: Foetal growth retardation (FGR) is a leading cause of perinatal death and long-term harms at survivors. Placental infarction plays a role in FGR, yet, no trials have evaluated whether low molecular weight heparins increase birth weight in ongoing FGR pregnancies. METHODS: An open-labelled randomized trial in Denmark during 2011-2016, including singleton pregnant women with FGR (estimated foetal weight < 2.3 percentile) diagnosed before gestational weeks 32...
August 10, 2018: Thrombosis Research
Massimo Radin, Irene Cecchi, Elena Rubini, Karen Schreiber, Dario Roccatello, Michael Mahler, Savino Sciascia
No abstract text is available yet for this article.
August 2, 2018: Thrombosis Research
Jose A Rodriguez, Josune Orbe, Goren Saenz-Pipaon, Gloria Abizanda, Natalia Gebara, Flavia Radulescu, Pedro M Azcarate, Luis Alonso-Perez, David Merino, Felipe Prosper, Jose A Paramo, Carmen Roncal
INTRODUCTION: Wound healing after myocardial infarction (MI) is mediated by different cell types, secreted proteins, components of the extracellular matrix (ECM) and, as increasing evidences suggest, extracellular vesicles (EVs). We aim to determine the dynamics of release and origin of EVs after MI, as well as their biological activity on endothelial cells (ECs). METHODS: MI was induced in WT mice and blood and tissues collected at baseline, 3, 15 and 30 days post-ligation for cardiac function (echocardiography) and histological evaluation...
August 1, 2018: Thrombosis Research
Katharine L Cheung, Beth A Bouchard, Mary Cushman
Chronic kidney disease (CKD) affects 30 million Americans and is associated with approximately a two-fold increased risk of venous thromboembolism (VTE). There is a graded increased risk of VTE across declining kidney function, as measured by estimated glomerular filtration rate (eGFR) and albuminuria. When patients with end-stage kidney disease (ESKD) experience VTE they are more likely than the general population to be hospitalized and they have a higher mortality. The incidence and consequences of VTE may also differ depending on the cause of kidney disease...
July 31, 2018: Thrombosis Research
Homam Ibrahim, Matthew T Rondina, Neal S Kleiman
Since the approval of the first transcatheter aortic valve replacement (TAVR) device in 2011, this technology has undergone substantial enhancements and exponential growth. However, valve thrombosis and residual paravalvular leaks (PVL) are among the challenges that require further investigation. Recently, monitoring von Willebrand factor (vWF) multimers has emerged as a tool to help evaluate the severity of PVL after TAVR. Following TAVR, vWF large multimers recovery have been documented. The role of large vWF multimers recovery and their interactions with platelets, and the endothelium have not been entirely elucidated...
July 30, 2018: Thrombosis Research
Asad E Patanwala, Stephanie M Seaman, Brian J Kopp, Brian L Erstad
OBJECTIVE: To compare rates of VTE occurrence in obese versus non-obese hospitalized patients who received UFH 5000 units subcutaneously q8 h. MATERIALS AND METHODS: This was a retrospective cohort study conducted in an academic medical center in the United States. Consecutive adult patients who were hospitalized during a 1-year time frame (2015) receiving UFH 5000 units subcutaneously q8 h for VTE prophylaxis. The primary outcome was occurrence of VTE during hospitalization...
July 29, 2018: Thrombosis Research
Matthew J Lawrence, Gareth Davies, Michael Nyberg, Janet Whitley, Vanessa Evans, Rhodri Williams, Ylva Hellsten, Phillip A Evans
BACKGROUND: The long term benefits of exercise on the cardiovascular status of a patient have been proven, however, their benefit/risk relationship with exercise intensity is unclear. Furthermore, many thromboembolic diseases such as myocardial infarction and ischaemic stroke are associated with profound catecholamine release. In this study we explore the relationship between catecholamine release and hemodynamic changes and their effect on coagulation. MATERIALS AND METHODS: Twelve healthy recreationally active males were recruited...
July 27, 2018: Thrombosis Research
Jason Chen, Christopher C Verni, Annukka Jouppila, Riitta Lassila, Scott L Diamond
Heparin proteoglycans (HEP-PGs) carry standard heparin-mediated anticoagulant properties as well as novel antiplatelet functions, a combination that may be significant for targeting multiple pathways in a single therapy. Recent work developing semisynthetic HEP-PG mimetics has shown promising results also in vivo, however flow conditions in vitro that replicate in vivo hemodynamics have not been reported. In this work, we present several assays (platelet calcium mobilization, aggregometry, microfluidic tests at venous and arterial hemodynamics) to characterize specific mechanistic effects of dual antiplatelet and anticoagulant (APAC) constructs as mimetics of HEP-PGs...
July 25, 2018: Thrombosis Research
Martin H Ellis, Sari Greenberg Dotan, Ariel Hammerman, Erez Battat, Estela Derazne, Orly Avnery
No abstract text is available yet for this article.
July 25, 2018: Thrombosis Research
Bader Al Rawahi, Mosaad Almegren, Marc Carrier
BACKGROUND: Anticoagulation with unfractionated heparin (UFH) or low molecular weight heparin (LMWH) is the mainstay for the treatment of patients with acute cerebral vein thrombosis (CVT) with or without intracranial hemorrhage (ICH). AIM: We conducted a systematic review and meta-analysis to determine the efficacy and safety of LMWH compared to UFH for the treatment of acute CVT. METHODS: An electronic search of MEDLINE, Pubmed, CENTRAL and Google Scholar was performed...
July 25, 2018: Thrombosis Research
Heleen Lameijer, Jan J J Aalberts, Dirk J van Veldhuisen, Karina Meijer, Petronella G Pieper
No abstract text is available yet for this article.
July 19, 2018: Thrombosis Research
Jenan Awesat, Iftach Sagy, Yosef S Haviv, Anat Rabinovich, Alan Jotkowitz, Elena Shleyfer, Leonid Barski
BACKGROUND: Anticoagulant induced renal injury has been previously described with Warfarin treatment. In the last decade direct oral anticoagulants (DOAC) were introduced. They include direct inhibitors of factor Xa (Rivaroxaban, Apixaban, Edoxaban) and a thrombin inhibitor (Dabigatran). There are isolated reports describing acute kidney injury (AKI) due to the use of DOACs. CASE REPORT: We report a clinical case of an 80-year-old patient recently started on Dabigatran for new onset atrial fibrillation...
July 19, 2018: Thrombosis Research
Paul Billoir, Sébastien Miranda, Louise Damian, Vincent Richard, Ygal Benhamou, Véronique Le Cam Duchez
INTRODUCTION: Circulating antiphospholipid antibodies (APL) induce vascular injury and endothelial dysfunction, which are associated with thrombotic events and/or fetal loss. We developed a model in which calibrated automated thrombin generation (CAT) is carried out in wells lined with cultured endothelial cells. Then we investigated how far b2GP1 antibodies provoked thrombin generation (TG) enhancing effects in these cells and/or in blood platelets. MATERIALS AND METHODS: Thrombin generation induced by different concentrations of tissue factor and different levels of endothelial aortic cell confluence was investigated by calibrated automated thrombogram...
July 17, 2018: Thrombosis Research
Marc A Rodger, Gregoire Le Gal, Nicole J Langlois, Barron Gin, Ranjeeta Mallick, Antonio Giulivi, Marisa Freedman, Michael J Kovacs
BACKGROUND: The "HERDOO2 rule" is a prospectively validated clinical decision rule used to identify low-risk women who can safely discontinue anticoagulants after completing 5-12 months of anticoagulant treatment for unprovoked venous thromboembolism. The VIDAS® d-Dimer (DD) assay, a component of the rule, was used in the derivation and validation of the rule at half the usual diagnostic cut-point for exclusion of venous thrombosis. It is unknown if other commercial DD assays used at a corresponding cut-point will categorize patients at high concordance with the VIDAS® DD...
July 17, 2018: Thrombosis Research
Adeel Arshad, Lynna Alnimer, Yazan Samhouri, Ruth Kouides, Timothy Woodlock
No abstract text is available yet for this article.
July 16, 2018: Thrombosis Research
Paul Monagle
Since Maureen Andrew began systematically describing thrombosis in children in 1994, there has been surprisingly slow process in advancing our knowledge in terms of diagnosis, prevention and treatment of thrombosis in children. There are a variety of reasons for this slow progress. Overwhelmingly the low incidence of thrombosis in children has been a major barrier. Second, the developmental, age related, changes in haemostasis mean that the physiology of haemostasis in children, and the interaction of the haemostatic system with anticoagulant drugs is constantly changing...
July 14, 2018: Thrombosis Research
S P Grover, P Saha, J Humphries, O T Lyons, A S Patel, J Serneels, B Modarai, M Mazzone, A Smith
BACKGROUND: Hypoxia within acute venous thrombi is thought to drive resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). Prolyl hydroxylase domain (PHD) isoforms are critical regulators of HIF1α stability. Non-selective inhibition of PHD isoforms with l-mimosine has been shown to increase HIF1α stabilisation and promote thrombus resolution. OBJECTIVE: The aim of this study was to investigate the therapeutic potential of PHD inhibition in venous thrombus resolution...
July 11, 2018: Thrombosis Research
Yue Wu, Sheng-An Su, Yao Xie, Jian Shen, Wei Zhu, Meixiang Xiang
Vascular endothelial injury (VEI) triggers pathological processes in various cardiovascular diseases, such as coronary heart disease and hypertension. To further elucidate the in vivo pathological mechanisms of VEI, many animal models have been established. For the easiness of genetic manipulation and feeding, murine models become most commonly applied for investigating VEI. Subsequently, countless valuable information concerning pathogenesis has been obtained and therapeutic strategies for VEI have been developed...
July 11, 2018: Thrombosis Research
Miquel Vázquez-Santiago, Noelia Vilalta, Biel Cuevas, Joaquim Murillo, Dolors Llobet, Raquel Macho, Núria Pujol-Moix, Marina Carrasco, José Mateo, Jordi Fontcuberta, José Manuel Soria, Juan Carlos Souto
INTRODUCTION: Platelets play a role in the pathophysiology of venous thromboembolism (VTE). Some studies have not found an association between VTE and platelet aggregation. The PFA-100® analyser is an in vitro assay for assessing primary haemostasis. But, there are no studies to evaluate its association with VTE. We investigated the contribution of the global platelet function and aggregation in the development of VTE. MATERIAL AND METHODS: We analysed 800 individuals who were included in the RETROVE Study (Riesgo de Enfermedad TROmboembólica VEnosa)...
July 11, 2018: Thrombosis Research
Vittorio Pengo, Gentian Denas
Antiphospholipid Syndrome (APS) is a condition characterized by the occurrence of thromboembolic events and/or pregnancy loss combined with one laboratory criterion among Lupus Anticoagulant- LAC, anticardiolipin -aCL, and anti β2-Glycoprotein I -aβ2GPI antibodies. Several hypotheses were put forward to explain the causal role of antibodies in the clinical events but none is fully convincing. Current laboratory diagnosis is based on three tests (LAC, IgG/IgM aβ2GPI and IgG/IgM aCL antibodies). The triple-positive profile (all the three tests positive, same isotype) is associated with a higher risk for thrombosis...
July 7, 2018: Thrombosis Research
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