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Thrombosis Research

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https://www.readbyqxmd.com/read/30316961/the-anticoagulant-effect-of-dabigatran-is-reflected-in-the-lag-time-and-time-to-peak-but-not-in-the-endogenous-thrombin-potential-or-peak-of-thrombin-generation
#1
Saartje Bloemen, Suzanne Zwaveling, Jonathan Douxfils, Mark Roest, Romy Kremers, François Mullier
INTRODUCTION: Calibrated automated thrombinography (CAT) is a sensitive method to assess coagulation. Dabigatran inhibits both free thrombin and the α2 macroglobulin (α2 M)-thrombin complex, which results in an erroneously increased peak and endogenous thrombin potential (ETP) without affecting lag time and time-to-peak. The aim of this study was to elucidate the artefacts in CAT when dabigatran is present. MATERIALS AND METHODS: Thrombin generation (TG) was measured in vitro by using CAT in the presence or absence of 6 μM idarucizumab in plasma spiked with dabigatran...
October 6, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30312799/blood-loss-and-cost-effectiveness-of-oral-vs-intravenous-tranexamic-acid-in-primary-total-hip-arthroplasty-a-randomized-clinical-trial
#2
Yuangang Wu, Yi Zeng, Qinsheng Hu, Mingyang Li, Xianchao Bao, Jian Zhong, Bin Shen
BACKGROUND: To assess the blood loss and cost-effectiveness of the oral and intravenous (IV) administration of tranexamic acid (TXA) for the treatment of primary total hip arthroplasty (THA). METHODS: From January 2017 to August 2017, 100 patients undergoing primary THA were enrolled and randomly divided into two groups. In the oral TXA group (N = 50), 1 g of TXA (2 tablets of 500 mg) was given 2 h before the incision, and the same dose was repeated 3 h and 6 h postoperatively...
October 6, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30312798/the-anticoagulant-treatment-for-sepsis-induced-disseminated-intravascular-coagulation-network-meta-analysis
#3
Tomoaki Yatabe, Shigeaki Inoue, So Sakamoto, Yuka Sumi, Osamu Nishida, Kei Hayashida, Yoshitaka Hara, Tatsuma Fukuda, Asako Matsushima, Akihisa Matsuda, Hideto Yasuda, Kazuto Yamashita, Moritoki Egi
INTRODUCTION: The benefits and harm caused by anticoagulant treatments for sepsis induced disseminated intravascular coagulation (DIC) remain unclear. Therefore, we performed a network meta-analysis to assess the effect of available anticoagulant treatments on patient mortality, DIC resolution and the incidence of bleeding complication in patients with septic DIC. MATERIALS AND METHODS: We considered all studies from four recent systematic reviews and searched the PubMed, MEDLINE, and Cochrane databases for other studies that investigated anticoagulant treatment for septic DIC using antithrombin, thrombomodulin, heparin, or protease inhibitors in adult critically ill patients...
October 6, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30321757/fibrin-monomers-derived-from-thrombogenic-dysfibrinogenemia-naples-type-variant-b%C3%AE-ala68thr-showed-almost-entirely-normal-polymerization
#4
LETTER
Tomu Kamijo, Kazuhiro Nagata, Chiaki Taira, Yumiko Higuchi, Shinpei Arai, Nobuo Okumura
No abstract text is available yet for this article.
October 4, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30321704/association-of-tafi-gene-polymorphisms-with-severity-of-coronary-stenosis-in-stable-coronary-artery-disease
#5
Chutima Rattanawan, Nantarat Komanasin, Nongnuch Settasatian, Chatri Settasatian, Upa Kukongviriyapan, Pongsak Intharapetch, Vichai Senthong
INTRODUCTION: Coronary stenosis is a consequence of atherosclerotic plaque progression that is associated with impaired fibrinolysis. Thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor 1 (PAI-1) are fibrinolysis inhibitors whose levels are influenced by acquired conditions and by polymorphisms. This study therefore aimed to investigate the association of TAFI and PAI-1 gene polymorphisms with severity of coronary stenosis in subjects with stable coronary artery disease (CAD)...
October 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30296717/venous-thrombosis-and-breast-cancer-in-older-women-racial-differences-in-risk-factors-and-mortality
#6
A S Faiz, S Guo, A Kaveney, C S Philipp
BACKGROUND: Risk factors for venous thromboembolism (VTE) in women with breast cancer are not known by race. OBJECTIVES: The purpose of our study was to determine risk factors for VTE and VTE associated mortality in white and black women with breast cancer. PATIENTS AND METHODS: The SEER-Medicare merged database (2000 to 2011) was used for women 65 years and older diagnosed with breast cancer. Stratified by race, logistic regression was used to examine risk factors for VTE and Cox proportional hazards regression was used to evaluate the effect of VTE on mortality...
October 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30321703/effect-of-genetic-and-patient-factors-on-warfarin-pharmacodynamics-following-warfarin-withdrawal-implications-for-patients-undergoing-surgery
#7
Salah Abohelaika, Hilary Wynne, Peter Avery, Emmanouela Kampouraki, Farhad Kamali
INTRODUCTION: Warfarin therapy is stopped for a fixed period prior to surgery to minimise risk of perioperative bleeding. However, anticoagulation subsides at varying rates among different patients. We evaluated the influence of genetic (CYP2C9 and VKORC1), patient and clinical factors on warfarin clearance and the decline in INR following warfarin withdrawal. MATERIALS AND METHODS: 131 patients completing a course of warfarin provided blood samples over 9 days for initial genotyping, and measurement of INR and plasma warfarin enantiomer concentrations...
October 1, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30312800/the-role-of-biomarkers-of-endothelial-activation-in-predicting-morbidity-and-mortality-in-patients-with-severe-sepsis-and-septic-shock-in-intensive-care-a-prospective-observational-study
#8
Yingying Fang, Chunsheng Li, Rui Shao, Han Yu, Qing Zhang
INTRODUCTION: Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU). MATERIALS AND METHODS: We studied 102 patients enrolled in the Beijing Chao-yang Hospital affiliated with the Capital Medical University. A receiver operating characteristic (ROC) curve were used to assess the prognostic values of the circulating adhesion Angiopoietin-2/Angiopoietin-1 ratio (Ang-2/Ang-1) and Angiopoietin-1/Tie-2 ratio (Ang-1/Tie-2), intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and thrombomodulin (TM)...
October 1, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30292134/reduced-nicotinamide-adenine-dinucleotide-phosphate-inhibits-rat-platelet-aggregation-and-p38-phosphorylation
#9
Yi Gu, Rui Sheng, Junchao Wu, Ying Zhou, Zheng-Hong Qin
Previous studies found that reduced nicotinamide adenine dinucleotide phosphate (NADPH) protected neurons against ischemia/reperfusion-induced injury. In addition to ROS reduction and ATP increment, preliminary data suggested that NADPH inhibited ADP and thrombin-induced platelet aggregation. As the effect of NADPH on platelet function was not reported by other investigators, the actions of NADPH on platelet function and mechanisms of actions were investigated in the present study. In vitro studies, the effects of different concentrations of NADPH on platelet aggregation induced by ADP (10 μM), thrombin (0...
September 28, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30273811/anti-pf4-heparin-antibodies-are-increased-in-hospitalized-patients-with-bacterial-sepsis
#10
LETTER
Satish Maharaj, Simone Chang
Heparin-induced thrombocytopenia (HIT) is caused by antibodies targeting platelet factor 4 (PF4)/heparin complexes. The immune response leading to HIT remains perplexing with many paradoxes. Unlike other drug induced reactions, anti-PF4/heparin antibody generation does not follow the classic immunologic response. Research in murine models suggests that that there is close interplay among infection, PF4 and the immune system. We hypothesized there would be a relatively higher prevalence of anti-PF4/heparin antibodies in patients hospitalized for sepsis...
September 27, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30312801/characterization-of-hemostasis-in-mice-lacking-the-novel-thrombosis-susceptibility-gene-slc44a2
#11
Julia Tilburg, Reheman Adili, Thankam S Nair, Megan E Hawley, David C Tuk, Madeline Jackson, Henri M Spronk, Henri H Versteeg, Thomas E Carey, Bart J M van Vlijmen, Chrissta X Maracle, Michael Holinstat
INTRODUCTION: Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute Carrier Family 44 Member 2 protein (SLC44A2). Thus far, SLC44A2 has not been studied in the context of thrombosis, and may be a unique contributor to thrombotic disease. Here we utilize mice lacking SLC44A2 (Slc44a2-/- ) to evaluate a possible role of SLC44A2 in hemostasis. METHODS: Slc44a2-/- mice were evaluated in key aspects of normal hemostasis including a challenge of vascular damage by applying laser induced injury to the cremaster muscle arteriole...
September 26, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30273810/the-relationship-between-heparanase-levels-thrombus-burden-and-thromboembolism-in-patients-receiving-unfractionated-heparin-treatment-for-prosthetic-valve-thrombosis
#12
Emrah Bayam, Macit Kalçık, Ahmet Seyfeddin Gürbüz, Mahmut Yesin, Ahmet Güner, Sabahattin Gündüz, Mustafa Ozan Gürsoy, Süleyman Karakoyun, Sinan Cerşit, Alev Kılıçgedik, Özkan Candan, Ali Yaman, Mehmet Özkan
INTRODUCTION: Procoagulant activity of heparanase has been recently described in several arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of heparanase with regard to thrombus burden, thromboembolism, and treatment success with unfractionated heparin (UFH) in patients with prosthetic valve thrombosis (PVT). METHODS: This study enrolled 79 PVT patients who received UFH for PVT and 82 controls. Plasma samples which were collected from patients both at baseline and after the UFH treatment and from controls at baseline only, were tested for heparanase levels by heparanase enzyme-linked immunosorbent assay...
September 26, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30278301/circulating-levels-of-tissue-factor-and-the-risk-of-thrombosis-associated-with-antiphospholipid-syndrome
#13
Laís Quinteiro Tobaldini, Fernanda Talge Arantes, Sabrina da Silva Saraiva, Bruna de Moraes Mazetto, Marina Pereira Colella, Erich Vinícius de Paula, Joyce Annichino-Bizzachi, Fernanda Andrade Orsi
The mechanisms behind the severe hypercoagulable state in antiphospholipid syndrome (APS) have not yet been fully elucidated. Knowledge on the etiology of thrombosis in APS is needed to improve treatment. We performed a case control study to evaluate the association of the levels of circulating tissue factor (TF) with thrombotic APS and unprovoked venous thromboembolism (VTE), as compared with controls without a history of thrombosis. Study participants were selected in the same geographic area. Linear regression was used to evaluate possible determinants of TF levels among controls and logistic regression was used to evaluate the association between TF, unprovoked VTE and t-APS...
September 25, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30268858/effect-of-occult-cancer-screening-on-mortality-in-patients-with-unprovoked-venous-thromboembolism
#14
Philippe Robin, Hans Martin Otten, Aurélien Delluc, Nick van Es, Marc Carrier, Pierre-Yves Salaün, Grégoire Le Gal
INTRODUCTION: Unprovoked venous thromboembolism (VTE) may be the first manifestation of an underlying cancer. We aimed to determine whether extensive screening for occult cancer in patients with unprovoked VTE was effective in reducing overall mortality among VTE patients included in prospective cancer screening studies. METHODS: This pre-specified analysis of a systematic review and individual patient data meta-analysis included prospective studies comparing extensive screening with limited screening strategies for detection of occult malignant disease in unprovoked VTE patients...
September 23, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30265883/management-and-outcome-of-major-bleeding-in-patients-receiving-vitamin-k-antagonists-for-venous-thromboembolism
#15
Farès Moustafa, Alexander Stehouwer, Pieter Kamphuisen, Joan Carles Sahuquillo, Ángel Sampériz, María Alfonso, Federica Pace, José María Suriñach, Ángeles Blanco-Molina, Patrick Mismetti, Manuel Monreal
BACKGROUND: The optimal management of major bleeding in patients receiving vitamin K antagonists (VKA) for venous thromboembolism (VTE) is unclear. METHODS: We used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry to assess the management and 30-day outcomes after major bleeding in patients receiving VKA for VTE. RESULTS: From January 2013 to December 2017, 267 of 18,416 patients (1.4%) receiving long-term VKA for VTE had a major bleeding (in the gastrointestinal tract 78, intracranial 72, hematoma 50, genitourinary 20, other 47)...
September 22, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30265882/efficacy-and-safety-of-multiple-boluses-of-oral-versus-intravenous-tranexamic-acid-at-reducing-blood-loss-after-primary-total-knee-arthroplasty-without-a-tourniquet-a-prospective-randomized-clinical-trial
#16
Guorui Cao, Jinwei Xie, Zeyu Huang, Qiang Huang, Guo Chen, Yiting Lei, Hong Xu, Fuxing Pei
INTRODUCTION: The aim of this study was to examine whether the administration of multiple boluses of oral or intravenous tranexamic acid (TXA) postoperatively were equivalent at reducing blood loss and the inflammatory and fibrinolytic responses in primary total knee arthroplasty (TKA) without a tourniquet. MATERIALS AND METHODS: In this prospective, double-blinded, randomized trial, patients undergoing primary THA were randomized into either an oral or intravenous TXA group...
September 22, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30267973/acquired-factor-v-inhibitor-related-severe-bleeding-due-to-unformed-prothrombinase-complex
#17
LETTER
Tomoko Mitsuhashi, Osamu Takamiya
No abstract text is available yet for this article.
September 20, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30248660/hypermucoviscous-klebsiella-pneumoniae-infections-induce-platelet-aggregation-and-apoptosis-and-inhibit-maturation-of-megakaryocytes
#18
Zhiwei Wang, Jianan Ren, Qinjie Liu, Jiayang Li, Xiuwen Wu, Weiping Wang, Jie Wu, Gefei Wang, Jieshou Li
INTRODUCTION: Different Klebsiella pneumoniae strains carry different virulence factors and antibiotic resistance and may cause thrombocytopenia. This study aimed to investigate the effects of different infections caused by K. pneumoniae on platelets. METHODS: Two hypermucoviscous K. pneumoniae strains and two classic strains were collected from clinical blood culture, and in both groups, there was a carbapenem-resistant strain and a carbapenem-sensitive strain...
September 20, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30268859/in-patients-with-unprovoked-vte-does-the-addition-of-fdg-pet-ct-to-a-limited-occult-cancer-screening-strategy-offer-good-value-for-money-a-cost-effectiveness-analysis-from-the-publicly-funded-health-care-systems
#19
Philippe Robin, Srishti Kumar, Pierre-Yves Salaun, Pierre-Yves Le Roux, Francis Couturaud, Benjamin Planquette, Adel Merah, Pierre-Marie Roy, Kednapa Thavorn, Grégoire Le Gal
INTRODUCTION: Unprovoked venous thromboembolism (VTE) may be the first manifestation of an undiagnosed cancer. We assessed the cost-effectiveness of 18 F-Fluorodesoxyglucose Positron Emission/Computed Tomography (FDG PET/CT) plus limited screening and limited screening strategies in patients with unprovoked VTE from the perspectives of the Ontario (Canada) and French health care systems. METHODS: We conducted a cost-effectiveness analysis based on a published randomized controlled trial of 394 patients aged 18 years or older who were diagnosed with unprovoked VTE...
September 19, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30261356/basic-coagulation-tests-as-surrogates-of-dabigatran-levels-in-a-pre-operative-setting-analysis-of-five-activated-partial-thromboplastin-time-reagents-and-thrombin-time
#20
Catherine Dubé, James D Douketis, Karen A Moffat, Sam Schulman, Normand Blais
BACKGROUND: In patients who are receiving dabigatran, a direct oral anticoagulant, measuring the anticoagulant effect before surgery may be needed in certain circumstances. Although the dilute thrombin time (dTT) can reliably measure dabigatran levels, it is not consistently available. More commonly used coagulation tests, including the activated partial thromboplastin time (aPTT) and thrombin time (TT) might have clinical utility but their accuracy is uncertain. METHODS: 103 patients stopped dabigatran 1-4 days before an elective surgery/procedure as part of a standardized dabigatran interruption protocol...
September 19, 2018: Thrombosis Research
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