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Thrombosis Research

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https://www.readbyqxmd.com/read/29224973/residual-pulmonary-embolism-as-a-predictor-for-recurrence-after-a-first-unprovoked-episode-results-from-the-reverse-cohort-study
#1
Tony Wan, Marc Rodger, Wanzhen Zeng, Philippe Robin, Marc Righini, Michael J Kovacs, Melanie Tan, Marc Carrier, Susan R Kahn, Philip S Wells, David R Anderson, Isabelle Chagnon, Susan Solymoss, Mark Crowther, Richard H White, Linda Vickars, Sadri Bazarjani, Grégoire Le Gal
BACKGROUND: The optimal duration of oral anticoagulant therapy after a first, unprovoked venous thromboembolism is controversial due to tightly balanced risks and benefits of indefinite anticoagulation. Risk stratification tools may assist in decision making. OBJECTIVES: We sought to determine the relationship between residual pulmonary embolism assessed by baseline ventilation-perfusion scan after completion of 5-7months of oral anticoagulant therapy and the risk of recurrent venous thromboembolism in patients with the first episode of unprovoked pulmonary embolism...
December 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29207321/a-multi-institutional-registry-of-pediatric-hospital-acquired-thrombosis-cases-the-children-s-hospital-acquired-thrombosis-chat-project
#2
Julie Jaffray, Arash Mahajerin, Guy Young, Neil Goldenberg, Lingyun Ji, Richard Sposto, Amy Stillings, Emily Krava, Brian Branchford
BACKGROUND: Pediatric hospital-acquired venous thromboembolism (HA-VTE) rates have increased dramatically. To achieve generalizable knowledge in the derivation and validation of HA-VTE risk factors and risk prediction models and inform future risk-stratified prevention strategies, multi-institutional studies are needed. OBJECTIVES: This paper presents an investigator-initiated, multicenter pediatric case-cohort study designed to identify risk factors for HA-VTE to create a HA-VTE risk prediction model...
December 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29220693/type-1-von-willebrand-disease-due-to-a-vicinal-cysteine-loss-p-c524y-disclosed-after-a-thrombotic-episode
#3
LETTER
Viviana Daidone, Eva Galletta, Alessandra Casonato
No abstract text is available yet for this article.
November 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29202320/screening-itself-for-disseminated-intravascular-coagulation-may-reduce-mortality-in-sepsis-a-nationwide-multicenter-registry-in-japan
#4
Yutaka Umemura, Kazuma Yamakawa, Mineji Hayakawa, Toshimitsu Hamasaki, Satoshi Fujimi
OBJECTIVES: Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality. We investigated whether DIC screening was associated with a survival benefit in patients with sepsis. DESIGN: Post hoc analysis of a nationwide multicenter retrospective cohort study...
November 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29198735/outpatient-therapy-for-acute-symptomatic-pulmonary-embolism-diagnosed-in-the-emergency-department-time-to-improve-the-evidence-base
#5
EDITORIAL
David Jiménez, Roger D Yusen
No abstract text is available yet for this article.
November 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29207322/identification-of-a-vte-rich-population-in-pediatrics-critically-ill-children-with-central-venous-catheters
#6
Minh Tran, Steven L Shein, Xinge Ji, Sanjay P Ahuja
BACKGROUND: The incidence of venous thromboembolism (VTE) is rising among inpatients in US hospitals, especially among kids with central venous catheters (CVCs) in the pediatric intensive care unit (PICU). OBJECTIVES: To identify a sub-group of "VTE-rich" population among PICU children, and to assess the effect of VTE on morbidity and mortality. METHODS: Data was extracted from a multicenter Virtual PICU Database, or VPS, for children with a CVC and presence of a VTE...
November 22, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178990/variants-in-chondroitin-sulfate-metabolism-genes-in-thrombotic-storm
#7
Karen Nuytemans, Thomas L Ortel, Lissette Gomez, Natalia Hofmann, Natalie Alves, Nicole Dueker, Ashley Beecham, Patrice Whitehead, Susan Hahn Estabrooks, Craig S Kitchens, Doruk Erkan, Leonardo R Brandão, Andra H James, Roshni Kulkarni, Marilyn J Manco-Johnson, Margaret A Pericak-Vance, Jeffery M Vance
INTRODUCTION: Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thrombotic disorders. MATERIAL AND METHODS: We completed whole exome sequencing on 26 TS patients, including 1 multiplex family, 13 trios and 12 isolated TS patients...
November 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178989/interaction-of-factor-vii-activating-protease-fsap-with-neutrophil-extracellular-traps-nets
#8
Simona Grasso, Ariane Neumann, Irene M Lang, Michael Etscheid, Maren von Köckritz-Blickwede, Sandip M Kanse
The circulating zymogen form of Factor VII activating protease (FSAP) can be activated by histones and nucleosomes in vivo. These cell-death-associated nuclear factors are also actively extruded into the extracellular space by neutrophils through a process called neutrophil extracellular trap (NET) formation (NETosis). NETs are thought to be involved in host defense, inflammation as well as thrombosis. We have investigated the bidirectional interactions of FSAP and NETs. Phorbol ester-mediated NET formation was marginally stimulated by FSAP...
November 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178986/thrombolytic-fucoidans-inhibit-the-tpa-pai1-complex-indicating-activation-of-plasma-tissue-type-plasminogen-activator-is-a-mechanism-of-fucoidan-mediated-thrombolysis-in-a-mouse-thrombosis-model
#9
LETTER
Younshick Choi, Soon-Ki Min, Roza Usoltseva, Artem Silchenko, Tatyana Zvyagintseva, Svetlana Ermakova, Jong-Ki Kim
No abstract text is available yet for this article.
November 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29175090/effect-of-fibrinogen-fibrin-and-fibrin-degradation-products-on-transendothelial-migration-of-leukocytes
#10
Sergiy Yakovlev, Leonid Medved
In spite of numerous studies on the involvement of fibrinogen in transendothelial migration of leukocytes and thereby inflammation, there is still no clear understanding of which fibrin(ogen) species can stimulate leukocyte transmigration. Although we have previously proposed that interaction of fibrin with the VLDL receptor (VLDLR) promotes leukocyte transmigration, there is no direct experimental evidence for the involvement of fibrin in this process. To address these questions, we performed systematic studies of interaction of VLDLR with fibrinogen, fibrin, and their isolated recombinant BβN- and βN-domains, respectively, and the effect of various fibrin(ogen) species on transendothelial migration of leukocytes...
November 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29175435/antiplatelet-effect-of-aspirin-during-24h-in-patients-with-type-2-diabetes-without-cardiovascular-disease
#11
Liv Vernstrøm, Kristian Løkke Funck, Erik Lerkevang Grove, Esben Laugesen, Jonathan Mathias Baier, Anne-Mette Hvas, Per Løgstrup Poulsen
INTRODUCTION: The antiplatelet effect of low-dose aspirin in patients with type 2 diabetes (T2DM) without cardiovascular disease (CVD) has not been thoroughly explored. We investigated if platelet aggregation increased during the standard 24-hour aspirin dosing interval in patients with T2DM compared to non-diabetic controls. Furthermore, we evaluated baseline platelet aggregation, the acute effects of aspirin on platelet aggregation and platelet turnover. MATERIALS AND METHODS: We included 21 patients with T2DM and 21 age and sex-matched controls...
November 20, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178987/time-to-threshold-as-a-new-indicator-of-circulatory-state-and-prognosis-in-patients-with-pulmonary-embolism
#12
Andreas Gunter Bach, Bettina-Maria Taute, Alexey Surov
BACKGROUND: Bolus tracking is commonly applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). TTT could be associated with the circulatory state, and ultimately with prognosis in patients with PE. AIM: The purpose of the present study was to examine the correlation of TTT with embolus burden, radiological and clinical parameters of circulatory state, and ultimately with 30-day mortality...
November 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178991/the-disseminated-intravascular-coagulation-score-is-a-novel-predictor-for-portal-vein-thrombosis-in-cirrhotic-patients-with-hepatitis-b
#13
ShaoBo Cui, Zhenmei Fu, YueMin Feng, XiaoYu Xie, XiaoWen Ma, TianTian Liu, Le Wang, Hao Wu, Qiang Zhu
BACKGROUND: The development of portal vein thrombosis (PVT) in cirrhotic patients has not been fully elucidated. The disseminated intravascular coagulation (DIC) score, which is based on readily available and relatively inexpensive coagulation parameters, including platelet count, fibrin-related markers, prothrombin time and fibrinogen, has not been reported regarding PVT development in cirrhotic patients to date. We aimed to evaluate the prognostic value of the DIC score in predicting PVT development in cirrhotic patients with hepatitis B...
November 15, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178988/adoption-of-bio-data-collagen-for-the-assessment-of-platelet-function-with-the-multiplate%C3%A2-analyzer
#14
LETTER
Marc Sorigue, Cristian Morales-Indiano, Lidia Ruiz-Garcia, Marta Peña, Javier Nieto, Alicia Martínez-Iribarren, Evarist Feliu, Maria Antonia Llopis, Elisa Orna
No abstract text is available yet for this article.
November 15, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29178985/a-complementary-role-for-tetraspanin-superfamily-member-tssc6-and-adp-purinergic-p2y12-receptor-in-platelets
#15
Mohammed Makkawi, David Howells, Mark D Wright, Denise E Jackson
Tumor-suppressing subchromosomal transferable fragment cDNA 6 (TSSC6) expression is restricted to hematopoietic organs and tissues where it plays a role in hematopoietic-cell function. The ADP purinergic receptor P2Y12 is mainly expressed by platelets with important clinical significance as a target for several clinically approved antithrombotic agents. We have previously shown a physical association between P2Y12 and TSSC6 in platelets. Hence our aim was to investigate whether this physical association is translated to functional effects...
November 15, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29157916/the-effect-of-bariatric-surgery-on-direct-acting-oral-anticoagulant-drug-levels
#16
Amihai Rottenstreich, Aviv Barkai, Ariela Arad, Bruria Hirsh Raccah, Yosef Kalish
OBJECTIVE: To determine direct-acting oral anticoagulant (DOAC) blood levels in post-bariatric surgery (BS) patients treated with long-term anticoagulation therapy. METHODS: We identified from medical records patients who underwent BS during 2005-2016 and who were treated with DOACs. We offered testing DOAC blood levels to these patients and to age, sex, body mass index, and serum creatinine-matched individuals treated by DOACs who did not undergo BS. RESULTS: Overall, 36 individuals were enrolled, 18 post-BS patients and 18 control subjects...
November 15, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29216479/diagnosis-of-deep-vein-thrombosis-recurrence-ultrasound-criteria
#17
REVIEW
Mario Maufus, Antoine Elias, Marie-Thérèse Barrellier, Gilles Pernod
INTRODUCTION: Recurrent deep vein thrombosis (DVT) is often suspected in patients after anticoagulant drug withdrawal. The clinical signs can be confused with the onset of post-thrombotic syndrome. For these reasons, diagnosis of DVT recurrence must rely on an accurate method. MATERIALS AND METHODS: In order to assess this challenging clinical issue, we performed an overview of the literature regarding ultrasound criteria for the diagnosis of recurrent DVT through a Medline search, which included articles published from January 1, 1980 to February 20, 2017...
November 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29136562/warfarin-resumption-following-anticoagulant-associated-intracranial-hemorrhage-a-systematic-review-and-meta-analysis
#18
Chatree Chai-Adisaksopha, Alfonso Iorio, Christopher Hillis, Deborah Siegal, Daniel M Witt, Sam Schulman, Mark Crowther
BACKGROUND: This study aims to assess the effect of warfarin resumption in patients who experienced warfarin-associated intracranial hemorrhage (ICH). METHODS: We conducted a systematic review and meta-analysis of studies evaluating the outcomes of adult patients who survived warfarin-associated ICH. We included studies that compared patients who resumed warfarin versus those who did not. RESULTS: Of 3145 studies screened, ten observational studies were included in the final analysis...
November 11, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29149707/over-expression-of-cyclooxygenase-2-in-increased-reticulated-platelets-leads-to-aspirin-resistance-after-elective-off-pump-coronary-artery-bypass-surgery
#19
Xiaoxuan Gong, Xuezhong Wang, Zhuowen Xu, Tiantian Zhu, Qiu Zhang, Jinying Zhang, Xiaowei Wang, Chunjian Li
INTRODUCTION: Aspirin resistance (AR) has been reported to present after coronary artery bypass graft causing saphenous vein graft failure. We aimed to investigate the factors that affect the anti-platelet effect of aspirin after off-pump coronary artery bypass surgery (OPCAB). MATERIALS AND METHODS: Thirty OPCAB candidates were successively recruited. Platelet count, platelet aggregation, reticulated platelet (RP), platelets' cyclooxygenase (COX)-1 and COX-2 expressions were determined during the peri-operative period...
November 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29145030/the-use-of-econsults-to-improve-access-to-specialty-care-in-thrombosis-medicine
#20
Leslie Skeith, Medina Mohamed, Alan Karovitch, Clare Liddy, Amir Afkham, Douglas Archibald, Erin Keely
INTRODUCTION: Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultation) eConsult service in the specialty of thrombosis medicine. METHODS: We conducted a cross-sectional study that included descriptive statistics of provider and patient demographic information and consultative-specific data...
November 7, 2017: Thrombosis Research
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