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Thrombosis Research

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https://www.readbyqxmd.com/read/28820967/identifying-predictors-for-bleeding-in-hospitalized-cancer-patients-a-cohort-study
#1
Rushad Patell, Alejandra Gutierrez, Lisa Rybicki, Alok A Khorana
BACKGROUND: Bleeding and thrombosis are both major complications of hospitalization in cancer patients. Concern regarding bleeding risk may reduce compliance with thromboprophylaxis. We assessed incidence of major and clinically relevant non-major bleeding (MCRNMB) and identified risk factors associated with in-hospital bleeding risk in hospitalized cancer patients. METHODS: We conducted a retrospective cohort study of consecutive adults admitted to general oncology floor at Cleveland Clinic from 11/2012-12/2014 (n=3525)...
August 12, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28822239/ischemic-stroke-rates-decline-in-patients-with-atrial-fibrillation-as-anticoagulants-uptake-improves-a-swedish-cohort-study
#2
Natalia Mochalina, Nazim Isma, Peter J Svensson, Anders Själander, Maj Carlsson, Tord Juhlin, Mattias Wieloch
INTRODUCTION: The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. MATERIALS AND METHODS: Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011-2013 in primary and secondary care and receiving oral anticoagulants (n=4847), aspirin (n=2850) or no treatment (n=3766) in Skåne County, Sweden...
August 11, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28822240/statin-use-and-venous-thromboembolism-in-cancer-a-large-active-comparator-propensity-score-matched-cohort-study
#3
Sherif M El-Refai, Esther P Black, Val R Adams, Jeffery C Talbert, Joshua D Brown
BACKGROUND: Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS: Patients with newly diagnosed cancer were followed for up to one year in a healthcare claims database (2010-2013). Three treatment groups included statin users, non-statin cholesterol lowering medication users, and an untreated group with pre-existing indications for statin therapy (hyperlipidemia, diabetes, or heart disease)...
August 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28800412/practical-issues-in-suspected-venous-thrombosis-in-general-practice-a-multicentre-prospective-cohort-in-primary-care
#4
LETTER
Sébastien Bruel, Mouzayan Ginzarly, Laurent Bertoletti, Patricia Fayard, Emmanuel Chapelier, Benjamin Seffert, Béatrice Simon-Momège, Paul Frappé
No abstract text is available yet for this article.
August 6, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28802975/impact-of-pneumatic-tube-system-transport-for-the-monitoring-of-heparin-therapy
#5
LETTER
Aurélien Lebreton, Alessandro Casini, Oana Bulla, Pierre Fontana
No abstract text is available yet for this article.
August 5, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28807377/crem-transgene-mice-an-animal-model-of-atrial-fibrillation-and-thrombogenesis
#6
A Bukowska, M Felgendreher, B Scholz, C Wolke, J S Schulte, E Fehrmann, E Wardelmann, M D Seidl, U Lendeckel, K Himmler, A Gardemann, A Goette, F U Müller
BACKGROUND: The molecular pathomechanisms underlying atrial thrombogenesis are multifactorial and still require detailed investigations. Transgenic mice with cardiomyocyte-directed expression of the transcriptional repressor CREM-IbΔC-X (CREM-TG) represent an experimental model of atrial fibrillation (AF) that shows a gradual, age-dependent progression from atrial ectopy to persistent AF. Importantly, this model develops biatrial thrombi. The molecular characteristics related to the thrombogenesis in CREM-TG mice have not been studied, yet...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28802974/characteristics-of-thrombin-generation-in-a-fulminant-porcine-sepsis-model
#7
Judit Tóth, Ildikó Beke Debreceni, Ádám Deák, Katalin Pető, Mariann Berhés, Endre Hajdú, Judit Szabó, Norbert Németh, Béla Fülesdi, János Kappelmayer
INTRODUCTION: The activation of blood coagulation has been demonstrated in most cases of sepsis, however previous studies in humans could not detect hypercoagulability with global hemostasis assays. In a fulminant porcine sepsis model we analysed coagulation screening tests and thrombin generation to evaluate hemostatic alterations. MATERIALS AND METHODS: Live Escherichia coli bacteria were inoculated to female pigs and prothrombin time, activated partial thromboplastin time, thrombin time and fibrinogen were measured by coagulometry...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28802144/the-effect-of-cyp2c19-genetic-polymorphism-and-non-genetic-factors-on-clopidogrel-platelets-inhibition-in-east-asian-coronary-artery-disease-patients
#8
LETTER
Arwa M Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Hamza Mostafa, Muhamad Ali S K Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim
No abstract text is available yet for this article.
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28783513/platelet-toll-like-receptor-tlr-expression-and-tlr-mediated-platelet-activation-in-acute-myocardial-infarction
#9
Kathryn E Hally, Anne C La Flamme, Peter D Larsen, Scott A Harding
Both platelets and Toll-like receptors (TLRs) contribute to acute myocardial infarction (AMI). Platelet activation can occur post-AMI and despite treatment with anti-platelet therapy. TLRs may represent an alternative platelet activation pathway, although the role of platelet-TLRs in AMI is poorly characterized. The aim of this study was to examine platelet-TLR expression and TLR-mediated platelet activation in healthy and AMI subjects. Here, we report that platelets from AMI patients exhibit upregulation of some, but not other, TLRs...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28783512/comparative-coagulation-studies-in-hibernating-and-summer-active-black-bears-ursus-americanus
#10
LETTER
Ann-Kristin U Friedrich, Jahnavi Kakuturu, Peter J Schnorr, Dean E Beyer, J Alexander Palesty, Eric W Dickson, Giacomo Basadonna, Mitchell A Cahan
No abstract text is available yet for this article.
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28780343/the-role-of-heparin-lead-in-in-the-real-world-management-of-acute-venous-thromboembolism-the-prefer-in-vte-registry
#11
Rupert Bauersachs, Giancarlo Agnelli, Anselm K Gitt, Manuel Monreal, Patrick Mismetti, Stefan N Willich, Petra Laeis, Eva-Maria Fronk, Peter Bramlage, Alexander T Cohen
INTRODUCTION: The appropriate strategy for initiating oral anticoagulant (OAC) therapy after an acute venous thromboembolism (VTE) depends on the intermediate-term anticoagulant to be used. While heparin bridging to vitamin K antagonists (VKA) is required, the direct oral anticoagulants (DOAC) rivaroxaban (30mg/day) and apixaban (10mg/day) can be initiated directly without parenteral anticoagulation. The objective was to evaluate OAC initiation patterns in clinical practice. MATERIALS AND METHODS: PREFER in VTE was an international, non-interventional registry conducted between January 2013 and August 2015...
July 28, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28780342/e-selectin-and-sicam-1-biomarkers-of-endothelial-function-predict-recurrence-of-venous-thromboembolism
#12
Olga Dzikowska-Diduch, Justyna Domienik-Karłowicz, Elżbieta Górska, Urszula Demkow, Piotr Pruszczyk, Maciej Kostrubiec
BACKGROUND: Risk factors for atherosclerosis and venous thromboembolism (VTE) overlap and are mostly associated with endothelial dysfunction (ED). We hypothesized that ED is present in patients after the first episode of acute pulmonary embolism (APE) and predicts the risk of VTE recurrence. DESIGN AND METHODS: Patients, at least 6months after the first episode of symptomatic, confirmed APE were included in this case-control study. The exclusion criteria were risk factors for cardiovascular diseases and other conditions associated with endothelial dysfunction...
July 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28778060/liver-up-regulation-of-adamts13-gene-expression-and-its-correlation-with-renal-markers-in-mice-with-type-1-diabetes-mellitus-and-nephropathy
#13
LETTER
M T Alves, M M O Ortiz, G V O P Reis, K F Rodrigues, C P Domingueti, P A S Carmo, A C S Silva, L M S Dusse, S A Araújo, A P Fernandes, K B Gomes
No abstract text is available yet for this article.
July 25, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28768210/assessing-renal-function-in-patients-receiving-doacs-cockcroft-gault-versus-estimated-glomerular-filtration-rate
#14
LETTER
Paul C Kruger, Marlene A Robinson, Ke Xu, Deborah M Siegal, John W Eikelboom, Vinai C Bhagirath
No abstract text is available yet for this article.
July 25, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28811041/post-thrombotic-syndrome-in-children
#15
Marisol Betensky, Neil A Goldenberg
The post-thrombotic syndrome (PTS) is the most common long-term complication of pediatric deep venous thrombosis (DVT). It is a burdensome condition that can lead to severe disability and poor quality-of-life of affected children. Although its pathophysiology remains poorly understood, it is thought to be the result of chronic venous hypertension. Recent studies have shown that the inflammatory response associated with an acute DVT likely plays a key role in the development of PTS. The Manco-Johnson Instrument and the modified Villalta Scale are the most widely used instruments for the diagnosis of pediatric PTS...
July 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28783511/antithrombin-debrecen-p-leu205pro-clinical-and-molecular-characterization-of-a-novel-mutation-associated-with-severe-thrombotic-tendency
#16
Anna Selmeczi, Réka Gindele, Péter Ilonczai, Attila Fekete, István Komáromi, Ágota Schlammadinger, Katalin Rázsó, Kitti B Kovács, Helga Bárdos, Róza Ádány, László Muszbek, Zsuzsanna Bereczky, Zoltán Boda, Zsolt Oláh
INTRODUCTION: Hereditary antithrombin (AT) deficiency is a rare thrombophilic disorder with heterogeneous genetic background and various clinical presentations. In this study we identified a novel AT mutation. Genotype-phenotype correlations, molecular characteristics and thrombotic manifestations of the mutation were investigated. MATERIALS AND METHODS: Thirty-one members of a single family were included. Clinical data was collected regarding thrombotic history...
July 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28760416/late-consequences-of-venous-thromboembolism-measuring-quality-of-life-after-deep-vein-thrombosis-and-pulmonary-embolism
#17
Waleed Ghanima, Hilde Skuterud Wik, Mazdak Tavoly, Tone Enden, Lars-Petter Jelsness-Jørgensen
The identification of specific post-thrombotic complications as well as an increased appreciation of the importance of patient-reported outcome measures have triggered an interest in studying health-related quality of life (HRQoL) in patients with a history of venous thromboembolism (VTE). In order to enable a comprehensive assessment of HRQoL in clinical trials it is recommended that both generic and disease-specific questionnaires be used. SF-36 and EQ-5D are the most widely used generic questionnaires in VTE studies, whereas several disease-specific questionnaires have been developed to evaluate HRQoL following deep vein thrombosis (DVT) and in chronic venous disease (CVD)...
July 23, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28759761/platelet-count-and-plateletcrit-are-associated-with-an-increased-risk-of-venous-thrombosis-in-females-results-from-the-retrove-study
#18
LETTER
Miquel Vázquez-Santiago, Noelia Vilalta, Andrey Ziyatdinov, Biel Cuevas, Raquel Macho, Núria Pujol-Moix, Marina Carrasco, José Mateo, Jordi Fontcuberta, José Manuel Soria, Juan Carlos Souto
No abstract text is available yet for this article.
July 23, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28753478/extensive-screening-for-occult-malignancy-in-unprovoked-venous-thromboembolism-a-meta-analysis
#19
Min Zhou, Liyong Zhang, Yong Ding, Yonggang Wang, Dong Yan, Changpo Lin, Zhenyu Shi, Weiguo Fu
BACKGROUND: The present meta-analysis aimed to evaluate the efficacy and sensitivity of an extensive screening strategy for occult malignant diseases in patients with unprovoked venous thromboembolism (VTE). METHODS: We conducted a systematic search of PubMed, Cochrane, EMBASE, and relevant article references. Meta-analysis was used to pool weighted relative risks (RR) for the rate of missed diagnosis, all-cause mortality, and cancer-related mortality. Heterogeneity test was performed using the inconsistency index...
July 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28743057/does-the-presence-of-clinical-symptoms-of-pulmonary-embolism-affect-the-outcome-of-patients-with-deep-vein-thrombosis
#20
LETTER
Paolo Prandoni, Anthonie W A Lensing, Martin H Prins, Franco Noventa, Sabina Villalta
No abstract text is available yet for this article.
July 21, 2017: Thrombosis Research
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