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Naunyn-Schmiedeberg's Archives of Pharmacology

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https://www.readbyqxmd.com/read/29781045/a-panoramic-view-on-gpcrs-the-1st-berlin-symposium-for-interdisciplinary-gpcr-research
#1
Andreas Bock, Marcel Bermudez
No abstract text is available yet for this article.
May 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29766222/cisplatin-increases-the-number-of-enterochromaffin-cells-containing-substance-p-in-rat-intestine
#2
Yusuke Obara, Takuji Machida, Yuho Takano, Saki Shiga, Asami Suzuki, Naoya Hamaue, Kenji Iizuka, Masahiko Hirafuji
We previously reported that cisplatin potentiated ileal 5-hydroxytryptamine (5-HT) metabolism and caused pathological changes with an inflammatory response in the delayed phase (72 h) after administration to rats. In the present study, we further investigated the time-dependent effect of cisplatin on ileal 5-HT metabolism and the effects of combining cisplatin and anti-inflammatory drugs on ileal tryptophan hydroxylase expression and pica (the consumption of non-nutritive materials such as kaolin). Cyclooxygenase-2 (COX-2) expression was significantly increased at 24 h after cisplatin (5 mg/kg, intraperitoneal) administration...
May 15, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29744559/chronic-kidney-disease-induced-atrial-structural-remodeling-and-atrial-fibrillation-more-studies-on-the-pathological-mechanism-are-encouraged
#3
EDITORIAL
Huiliang Qiu, Chunlan Ji, Huanlin Wu, Chuan Zou
No abstract text is available yet for this article.
May 10, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29736621/molecular-basis-for-the-sensitivity-of-trp-channels-to-polyunsaturated-fatty-acids
#4
Marc Riehle, Dmitry Tsvetkov, Björn-Oliver Gohlke, Robert Preissner, Christian Harteneck, Maik Gollasch, Bernd Nürnberg
Transient receptor potential (TRP) channels represent a superfamily of unselective cation channels that are subdivided into seven subfamilies based on their sequence homology and differences in gating and functional properties. Little is known about the molecular mechanisms of TRP channel regulation, particularly of the "canonical" TRP (TRPC) subfamily and their activation by polyunsaturated fatty acids (PUFAs). Here, we analyzed the structure-function relationship of Drosophila fruit fly TRPC channels...
May 8, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29736620/cardioprotective-effect-of-zingerone-against-oxidative-stress-inflammation-and-apoptosis-induced-by-cisplatin-or-gamma-radiation-in-rats
#5
Ahmed F Soliman, Lobna M Anees, Doaa M Ibrahim
Despite their clinical benefits in cancer treatment, the deleterious effects on heart following chemo/radiotherapy are of increasing importance. Zingerone, a natural polyphenol, possesses multiple biological activities, such as antioxidant and anti-inflammatory. Thus, the current study was designed to assess the potential cardioprotective effects of zingerone against cisplatin or γ-radiation. Zingerone was given by intragastric intubation (25 mg/kg) daily for three successive weeks prior to the induction of cardiotoxicity using a single dose of cisplatin (20 mg/kg, i...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29732526/neuroprotective-evidence-of-alpha-lipoic-acid-and-desvenlafaxine-on-memory-deficit-in-a-neuroendocrine-model-of-depression
#6
Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Germana Silva Vasconcelos, Ingridy da Silva Medeiros, Márcia Calheiros Chaves Silva, Fayçal Mouaffak, Oussama Kebir, Cláudio Manuel Gonçalves da Silva Leite, Manoel Cláudio Azevedo Patrocinio, Danielle Macedo, Silvânia Maria Mendes Vasconcelos
Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From the 15th to 21st day, the animals were divided in groups: vehicle, CORT, CORT+desvenlafaxine (DVS) 10 or 20 mg/kg, ALA 100 or 200 mg/kg, DVS10+ALA100, DVS20+ALA100, DVS10+ALA200, or DVS20+ALA200. Tail suspension (TST), social interaction (SIT), novel object recognition (NOR), and Y-maze tests were conducted...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29728739/decreased-contraction-induced-by-endothelium-derived-contracting-factor-in-prolonged-treatment-of-rat-renal-artery-with-endoplasmic-reticulum-stress-inducer
#7
Makoto Ando, Takayuki Matsumoto, Kumiko Taguchi, Tsuneo Kobayashi
Recent evidence suggests that endoplasmic reticulum (ER) stress is involved in the regulation of various physiological functions, including those of the vascular system. However, the relationship between ER stress and vascular function is poorly understood. The endothelial cells control the vascular tone by releasing endothelium-derived relaxing factors and contracting factors (EDCFs). We hypothesized that tunicamycin, an inducer of ER stress, modifies endothelium-dependent contraction and prostaglandins (PGs), a major class of EDCFs, induced contractions in the rat renal artery in rats...
May 4, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29721577/curcumin-protects-heart-tissue-against-irinotecan-induced-damage-in-terms-of-cytokine-level-alterations-oxidative-stress-and-histological-damage-in-rats
#8
Osman Ciftci, Nese Basak Turkmen, Asli Taslıdere
Irinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin (CRC) was determined in terms of antioxidant and anti-inflammatory properties against heart damage, caused by CPT-11, in rats. Rats were divided randomly into four equal groups (Control, CPT-11, CRC, and CPT-11 + CRC). CPT-11 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg-1 was given orally...
May 2, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29704028/contractile-responses-in-intact-and-mucosa-denuded-human-ureter-a-comparison-with-urinary-bladder-detrusor-preparations
#9
Melanie Roedel, Ursula Ravens, Michael Kasper, Manfred P Wirth, Thomas A Jepps, Stefan Propping
Human proximal and distal ureter tissues were studied to clarify whether the presence of mucosa affects contractile responses. In histological studies, human ureter was compared with urinary bladder (detrusor). Contractions in response to high KCl solution, phenylephrine, and carbachol were measured in intact and mucosa-denuded strips of human ureter. Tissue sections of human bladder and ureter were used for histological staining. Thirty-four percent of the ureter strips contracted spontaneously with highly variable patterns, and this was affected neither by mucosa nor by proximal or distal tissue origin...
April 28, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29691608/effects-of-the-monoamine-stabilizer-osu6162-on-locomotor-and-sensorimotor-responses-predictive-of-antipsychotic-activity
#10
Vívian T da Silveira, Jivago Röpke, Ana L Matosinhos, Ana C Issy, Elaine A Del Bel, Antônio C de Oliveira, Fabrício A Moreira
The monoamine stabilizer (3S)-3-[3-(methenesulfonyl)phenyl]-1-propylpiperidine hidrochloride [(-)-OSU6162] is a promising compound for the treatment of neurological and psychiatric disorders, such as schizophrenia. Here, we tested the hypothesis that (-)-OSU6162 prevents hyperlocomotion and sensorimotor deficits in prepulse inhibition of the startle response (PPI) induced by psychomimetic drugs. Male Swiss mice received injections of (-)-OSU6162 (1, 3, 10, or 30 mg/kg), and their motor responses were investigated in the open field and in the catalepsy tests, which predicts liability to induce sedation and extrapyramidal side effects, respectively...
April 24, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29691607/protective-effect-of-nerolidol-loaded-in-nanospheres-against-cerebral-damage-caused-by-trypanosoma-evansi
#11
Matheus D Baldissera, Carine F Souza, Roberta C Riéffel, Maiara C Velho, Andiara P Ramos, Kátia Nascimento, Michele R Sagrillo, Aline F Ourique, Aleksandro S da Silva, Lenita M Stefani, Silvia G Monteiro
Trypanosoma evansi is a zoonotic parasite associated with high animal mortality that has gained importance due to its capacity to infect humans. Recently, some evidences have demonstrated that T. evansi infection causes severe genotoxic and cytotoxic damage in brain cells, contributing to the pathogenesis and clinical signs of the disease. In this sense, the aim of this study was to evaluate whether nerolidol-loaded in nanospheres, a natural compound with trypanocidal and neuroprotective effects, is able to protect the brain tissue from the cytotoxic and genotoxic effects found during T...
April 24, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29680917/scutellarin-suppresses-neuroinflammation-via-the-inhibition-of-the-akt-nf-%C3%AE%C2%BAb-and-p38-jnk-pathway-in-lps-induced-bv-2-microglial-cells
#12
Pengtao You, San Fu, Kun Yu, Yu Xia, Hezhen Wu, Yanfang Yang, Chaozhi Ma, Dan Liu, Xin Chen, Jun Wang, Xiaochuan Ye, Yanwen Liu
In vitro and in vivo studies indicate that scutellarin (SCU) exerts anti-inflammatory effects in the central nervous system (CNS) and inhibits microglia activation. This study investigated the anti-neuroinflammation molecular mechanisms exerted by scutellarin in LPS-induced BV-2 cells. The results showed that production of TNF-α, IL-1β, IL-6, and NO and TNF-α, IL-1β, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay. Western blot analysis indicated that NF-κB-p65 phosphorylation was suppressed by scutellarin via inhibition of IκB degradation and IKKβ activation, which coincided with blockage of nuclear translocation of NF-κB as shown by immunofluorescent staining...
April 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29680916/letter-to-the-editor
#13
Mahdieh Raeeszadeh, Javad Beheshtipour
In order to calculated-measure the low-density lipoprotein cholesterol (LDL-C), the Friedewald formula is used. LDL can be calculated by Friedewald formula in this way: total cholesterol (TC) minus high-density lipoprotein (HDL)-cholesterol minus triglycerides (TG)/5 in milligrams per deciliter. In the article entitled "Agmatine protects rat liver from nicotine-induced hepatic damage via antioxidative, antiapoptotic, and antifibrotic pathways" published in the same journal (Vol, 389, pp. 1341-1351), LDL-C has been calculated in this way: LDL-C = TC - [HDL-C - (TG/5)] which is not in accordance with the Friedewald formula and thus the result is false...
April 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29671021/protective-effect-of-vinpocetine-against-neurotoxicity-of-manganese-in-adult-male-rats
#14
Rania I Nadeem, Hebatalla I Ahmed, Bahia M El-Sayeh
Manganese (Mn) is required for many essential biological processes as well as in the development and functioning of the brain. Extensive accumulation of Mn in the brain may cause central nervous system dysfunction known as manganism, a motor disorder associated with cognitive and neuropsychiatric deficits similar to parkinsonism. Vinpocetine, a synthetic derivative of the alkaloid vincamine, is used to improve the cognitive function in cerebrovascular diseases. It possesses antioxidant and antiinflammatory properties...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29671020/luteolin-alleviates-cardiac-ischemia-reperfusion-injury-in-the-hypercholesterolemic-rat-via-activating-akt-nrf2-signaling
#15
Jin-Ting Yang, Jue Wang, Xin-Ru Zhou, Chi Xiao, Yang-Yun Lou, Li-Hui Tang, Feng-Jiang Zhang, Ling-Bo Qian
Myocardial ischemia/reperfusion (I/R) injury in hypercholesterolemia is associated with oxidative stress, while luteolin is known to reduce oxidative stress by activating Akt/nuclear factor erythroid-2-related factor 2 (Nrf2) signaling and alleviate cardiac I/R injury. Here, we investigated whether luteolin pretreatment diminishes myocardial I/R injury in hypercholesterolemic rats by activating Akt/Nrf2 signaling. Hypercholesterolemic rats were produced by 2% cholesterol diet for 8 weeks. Luteolin (100 mg/kg/day, i...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29671019/lixisenatide-a-novel-glp-1-analog-protects-against-cerebral-ischemia-reperfusion-injury-in-diabetic-rats
#16
Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalifa
Type 2 diabetes mellitus (T2DM) is a major risk factor for ischemic stroke accompanied by vascular dysfunction and poor cerebrovascular outcome. Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties. This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury. T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29666896/calpain-inhibition-attenuates-bleomycin-induced-pulmonary-fibrosis-via-switching-the-development-of-epithelial-mesenchymal-transition
#17
Yuan Liu, Bing Liu, Gu-Qin Zhang, Jing-Feng Zou, Meng-Lin Zou, Zhen-Shun Cheng
Calpains are intracellular calcium-dependent cysteine proteases, which cleave several substrates proteins, have been proven to play important roles in lung fibrosis. The aim of this study was to investigate the effects of calpain on bleomycin (BLM)-induced pulmonary fibrosis. A lung fibrosis mice model was established successfully by intraperitoneal injection of bleomycin. Calpeptin, a highly selective inhibitor of calpain activation, was administered three times weekly after bleomycin injection. Histological examination was used to assess the fibrosis...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29666895/suppression-of-glutathione-s-transferases-potentiates-the-cytotoxic-effect-of-phenethyl-isothiocyanate-in-cholangiocarcinoma-cells
#18
Ornanong Tusskorn, Tueanjai Khunluck, Auemduan Prawan, Laddawan Senggunprai, Upa Kukongviriyapan, Veerapol Kukongviriyapan
Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables. Previous studies have shown that the effect of PEITC-induced cell death declines rapidly after administration. The metabolic fate of PEITC is modulated by glutathione S-transferases (GST). In this study, we investigated whether GST activity modulates PEITC-induced cytotoxicity on cholangiocarcinoma (CCA) cells. The sensitivity of KKU-M214 and KKU-100 cells to PEITC was associated with GST activity...
April 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29663016/gallic-acid-a-phenolic-compound-isolated-from-mimosa-bimucronata-dc-kuntze-leaves-induces-diuresis-and-saluresis-in-rats
#19
Fabile Schlickmann, Thaise Boeing, Luisa Nathália Bolda Mariano, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Luisa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza, Valdir Cechinel-Filho
Although present in the leaves of Mimosa bimucronata (DC.) and many other medicinal plants commonly used to augment urinary volume excretion, the effects of gallic acid as a diuretic agent remain to be studied. Wistar rats were orally treated with vehicle, hydrochlorothiazide, or gallic acid. The effects of gallic acid in the presence of hydrochlorothiazide, furosemide, amiloride, L-NAME, atropine, and indomethacin were also investigated. Diuretic index, pH, conductivity, and electrolyte excretion were evaluated at the end of the experiment (after 8 or 24 h)...
April 16, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29656366/sodium-selenite-ameliorates-both-intestinal-and-extra-intestinal-changes-in-acetic-acid-induced-colitis-in-rats
#20
Samar M Soliman, Walaa Wadie, Samia A Shouman, Afaf A Ainshoka
Selenium and its derivatives including sodium selenite (sod sel) belong to the group of essential trace elements needed for proper health and nutrition. They are fairly safe and possess antioxidant and anti-inflammatory properties. The aim of present investigation was to elucidate the effect of sod sel on experimental colitis model in rats. Colitis was induced by intrarectal instillation of 4% (v/v) acetic acid. Two hours later, sod sel was given to rats on a daily basis for 15 consecutive days. Clinical symptoms, colon mass index, spleen weight inflammatory markers, hematological, biochemical, macroscopic, and histological changes were determined...
April 14, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
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