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Annals of Clinical Biochemistry

Brian Shine, Julian H Barth
No abstract text is available yet for this article.
September 12, 2018: Annals of Clinical Biochemistry
Gautam Das, Peter N Taylor, Hussam Abusahmin, Amer Ali, Brian P Tennant, John Geen, Onyebuchi Okosieme
Background Microalbuminuria represents vascular and endothelial dysfunction. Thyroid hormones can influence urine albumin excretion as it exerts crucial effects on the kidney and on the vascular system. This study explores the relationship between serum thyrotropin and urine albumin excretion in euthyroid patients with diabetes. Methods A total of 433 patients with type 1 or 2 diabetes were included in this retrospective cross-sectional study. Data included anthropometric measurements and biochemical parameters from diabetes clinic...
September 11, 2018: Annals of Clinical Biochemistry
Ramin Ghodsi, Sorayya Kheirouri, Rahmat Nosrati
Background Abundant evidence indicate the increased levels of oxidative stress in patients with autism. Advanced glycation end products and advanced lipoxidation end products and their precursors play a major role in increased oxidative stress in numerous metabolic and neurologic diseases. Carnosine is a natural dipeptide with antiglycation effects. The aim of this trial was to examine the effects of carnosine supplementation on the advanced glycation end products and the precursors of advanced lipoxidation end products in patients with autism...
September 6, 2018: Annals of Clinical Biochemistry
Zhen Chen, Yue Wu, Rojeet Shrestha, Zijun Gao, Yaoyao Zhao, Yusuke Miura, Akiko Tamakoshi, Hitoshi Chiba, Shu-Ping Hui
BACKGROUND: Short-chain fatty acid (SCFA) are primarily absorbed through the portal vein during lipid digestion, which is utilized as the energy source, as well as prevents type 2 diabetes and some cancers. However, reports on the determination of these SCFA in human serum are limited. METHODS: Blood samples from human subjects (n = 547, male/female = 246/301, age 58.85 ± 12.57) were collected. Saponification was applied to obtain total FA. After derivatization by 2-nitrophenylhydrazine, FA 4:0 and FA 6:0 were measured by liquid chromatography-mass spectrometry (LC-MS/MS)...
September 5, 2018: Annals of Clinical Biochemistry
Michael J Duffy
Measurement of genetically altered DNA shed from tumours into the circulation can potentially provide a new generation of blood-based cancer biomarkers. Compared with tissue DNA biomarkers which require surgery or biopsy, samples for circulating tumour DNA assays can be obtained with minimal inconvenience and at lower cost. Furthermore, in contrast to tissue, the use of circulating tumour DNA allows serial monitoring, faster delivery of results and potentially provides an integrative representation of genetic alterations across all tumour sites within a patient...
September 5, 2018: Annals of Clinical Biochemistry
Yu-Hung Chang, Hsien-Chang Lin, Der-Wei Hwu, Dao-Ming Chang, Kun-Chen Lin, Yau-Jiunn Lee
Background Serum cytokeratin-18 is believed to be a marker of hepatic cell damage. However, few studies have discussed about the serum cytokeratin-18 concentration in type 2 diabetes mellitus patients and investigated its association with non-alcoholic fatty liver disease as well as metabolic biomarkers. Methods Healthy participants and type 2 diabetes mellitus patients were enrolled. Physical and metabolic factors were recorded, and non-alcoholic fatty liver disease was screened by abdominal ultrasound and the fatty liver index...
August 27, 2018: Annals of Clinical Biochemistry
Alison Avenell, Mark J Bolland, Andrew Grey
No abstract text is available yet for this article.
August 27, 2018: Annals of Clinical Biochemistry
Guojun Zhang, Chunjiao Yang, Xixiong Kang, Zhixian Gao, Hong Wan, Yunpeng Liu
Background The differential diagnosis between postneurosurgical bacterial meningitis and aseptic meningitis remains challenging both for the clinician and the laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. Methods This prospective cohort study included patients with suspected bacterial meningitis after neurosurgery. The patients were divided into two groups according to the diagnostic criteria of meningitis involving a postneurosurgical bacterial meningitis group and a postneurosurgical aseptic meningitis group...
August 27, 2018: Annals of Clinical Biochemistry
Paul S Cullis, Frith Cull, Gordon Bruce, Allan Johnston, Hetal Patel, Lesley Jackson, Peter Galloway, Gregor Walker
Background Infants with gastrointestinal conditions and poor weight gain are administered sodium supplementation based on urinary sodium concentrations. However, the reference range of urinary electrolytes is unknown. The aim of this study was to ascertain the normal values of urinary electrolytes in healthy, term infants. Secondary aims were to establish the relationship between urinary electrolytes with weight velocity and feeding practices. Methods Healthy, term (≥37 weeks' gestation) infants were recruited...
August 21, 2018: Annals of Clinical Biochemistry
Yuji Takahashi, Yasuki Ito, Toshihiro Sakurai, Norio Wada, Atsushi Nagasaka, Masato Fujikawa, Hitoshi Chiba, Shu-Ping Hui
Background Apolipoprotein E-containing high-density lipoprotein shows antiatherogenic properties in vitro. There is a need for a homogeneous assay to determine the concentration of apolipoprotein E-containing high-density lipoprotein for in vivo studies. Methods In the proposed homogeneous assay, lipoproteins other than apolipoprotein E-containing high-density lipoprotein were eliminated in the first step. Apolipoprotein E-containing high-density lipoprotein-cholesterol was measured in the second step. The control study used a 13% polyethylene glycol precipitation assay (control assay)...
August 16, 2018: Annals of Clinical Biochemistry
Ewa Gruszewska, Bogdan Cylwik, Monika Gudowska, Anatol Panasiuk, Robert Flisiak, Lech Chrostek
Background The synthesis and glycosylation of glycoproteins and glycolipids take place in the liver. Thus, liver diseases may affect serum concentrations of some carbohydrate derivatives, especially the concentration of sialic acid which is attached to the end of oligosaccharide chains. The aim of this study was to measure and compare the serum concentration of total sialic acid in chronic hepatitis B and C. The hypothesis is that both viruses responsible for the development of inflammation work differently at the cellular level...
August 16, 2018: Annals of Clinical Biochemistry
Geert Roozen, Ingrid Revet, Reinier Raymakers, Hans Kemperman
The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000  μg/L and 138,000  μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking...
August 9, 2018: Annals of Clinical Biochemistry
Sophie Hepburn, Taruna Likhari, Patrick J Twomey
No abstract text is available yet for this article.
August 8, 2018: Annals of Clinical Biochemistry
Pauline Ashfield-Watt, Kate Haralambos, Rhiannon Edwards, Delyth Townsend, Rob Gingell, Kah Wa Li, Steve E Humphries, Ian McDowell
Background and aim Familial hypercholesterolaemia is caused by variants in the low-density lipoprotein cholesterol metabolic pathway involving LDLR, APOB and PCSK9 genes. A national genetic testing service in Wales, UK has observed that no familial hypercholesterolaemia variant is found in almost 80% patients with the familial hypercholesterolaemia phenotype. It has recently been suggested that some adult patients with a familial hypercholesterolaemia phenotype may have cholesteryl ester storage disease which can also present as a mixed hyperlipidaemia...
August 8, 2018: Annals of Clinical Biochemistry
Jennifer S Johnstone, Michael J Murphy
Background Communicating abnormal results to requesting clinicians is an essential part of clinical authorisation. Guidance from the Royal College of Pathologists on communication of critical/unexpected results is issued as 'advice to pathologists'. The 2017 guidelines advise rapid communication of serum potassium results ≤2.5 mmol/L and ≥6.5 mmol/L. Little is known about what happens after the results have been communicated. We wished to establish answers to the following questions: Are phoned results acted on? If so, when? What is the outcome of any action taken? Methods A prospective study of primary care potassium results authorised out of hours was undertaken...
August 2, 2018: Annals of Clinical Biochemistry
Hong-Ying Chen, Shi-Cheng Li, Lian-Feng Chen, Wei Wang, Yu Wang, Xiao-Wei Yan
Background Smoking cessation was associated with improved prognosis of coronary artery disease. This study was designed to investigate the effect of smoking cessation on high-density lipoprotein functionality in coronary artery disease patients. Methods In this prospective, randomized and parallel controlled study, coronary artery disease smokers ( n = 28) and healthy smokers ( n = 30) were divided into smoking cessation group and continuous smoking group, respectively. Blood samples were collected before and after three-month smoking cessation...
August 1, 2018: Annals of Clinical Biochemistry
Jinny Jeffery, Amy R Frank, Stephanie Hockridge, Hagen Stosnach, Sean Costelloe
BACKGROUND: Total Reflection X-Ray Fluorescence (TXRF) is a comparably new method for the measurement of trace elements in biological samples. METHODS: Results obtained by TXRF were compared to Atomic Absorption Spectroscopy for Cu and Zn and Inductively Coupled Plasma Mass Spectrometry for Cu, Zn and Se in patient serum. The TXRF assay was characterised for accuracy; recovery; intra- and inter-assay imprecision (using patient samples, external quality assurance, and quality control materials); limit of blank; limit of detection; linearity; interference; and stability of prepared samples...
July 30, 2018: Annals of Clinical Biochemistry
Stephen E Langabeer
No abstract text is available yet for this article.
July 30, 2018: Annals of Clinical Biochemistry
Ceri Rowe, Sarah Rabet
No abstract text is available yet for this article.
September 2018: Annals of Clinical Biochemistry
Paul Collinson
No abstract text is available yet for this article.
September 2018: Annals of Clinical Biochemistry
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