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Annals of Clinical Biochemistry

Loretta Theresa Ford, Jonathan David Berg
Novel psychotropic substances (NPS) also known as legal highs are a major concern in UK prisons, fuelling violence and putting a strain on resources for inmates requiring medical treatment for adverse effects. We provide a clinical toxicology service including routine screening for NPS. In 2015 we were approached by Her Majesty Prison Service (HMPS) search dog training team to advise on which NPS to target, and again in 2016 to further provide analytical support to test five letters which the dogs positively identified for NPS during routine searches of prison mail rooms...
January 1, 2018: Annals of Clinical Biochemistry
Samantha Mellen, Maria de Ferrars, Claire Louise Chapman, Sarah Bevan, James Turvill, Daniel Charles Turnock
BACKGROUND: Faecal immunochemical testing (FIT) is increasingly being used to triage symptomatic patients for suspected colorectal cancer. However, there are limited data on the effect of pre-analytical factors on faecal haemoglobin (f-Hb) when measured by FIT. The aim of this work was to evaluate the stability of f-Hb in faeces and to compare two methods of f-Hb sampling for FIT. METHODS: Six patients provided faeces for f-Hb measurement which were transferred into specialised collection devices at baseline and at 1, 2, 3 and 7 days after storage at either room temperature or 4°C...
January 1, 2018: Annals of Clinical Biochemistry
Helen Olivia Cordy, Soha Zouwail
No abstract text is available yet for this article.
January 1, 2018: Annals of Clinical Biochemistry
Hiroshi Ihara, Sachiko Kiuchi, Takayuki Ishige, Motoi Nishimura, Kazuyuki Matsushita, Mamoru Satoh, Fumio Nomura, Mine Yamashita, Isamu Kitajima, Naoko Tsugawa, Toshio Okano, Kouichi Hirota, Masakazu Miura, Masayuki Totani, Naotaka Hashizume
BACKGROUND: To assess vitamin D nutritional status, serum total 25-hydroxyvitamin D [25(OH)D] concentration is measured. We used six automated 25(OH)D immunoassays (AIAs) available in Japan and certified by the Vitamin D Standardization Program (VDSP) at U.S. CDC to assess the concordance of assay results. METHODS: Serum total 25(OH)D concentrations in SRM 972a and 20 sera from patients were determined using three liquid chromatography-tandem mass spectrometry (LC-MS/MS) and six AIAs (pilot study), and an additional 110 sera were assessed by the six AIAs (surveillance study)...
January 1, 2018: Annals of Clinical Biochemistry
James M Hawley, Laura J Owen, Miguel De Bono, John Newell-Price, Brian G Keevil
BACKGROUND: Measurement of serum dexamethasone during the overnight dexamethasone-suppression test (ONDST) has been recommended to reduce false positive results when investigating Cushing's syndrome or increasingly commonly found adrenal incidentalomas. Despite this, there remains a paucity of well-validated dexamethasone methods currently available. Here, we describe the development of a rapid and sensitive LC-MS/MS serum dexamethasone assay and validate its utility in a cohort of postmenopausal females...
January 1, 2018: Annals of Clinical Biochemistry
Ikki Shimizu, Yuji Hiramatsu, Yasue Omori, Masao Nakabayashi
Background:To clarify the relationship between glycated hemoglobin (HbA1c) and glycated albumin (GA) levels during pregnancy with neonatal outcomes, a multicenter study was conducted by the Japanese Society of Diabetes and Pregnancy. Methods:A total of 136 patients (type 1: n = 47, type 2: n = 89) who enrolled in the study were diagnosed based on the Japanese Diabetes Society diagnostic criteria for diabetes mellitus. Thresholds for HbA1c and GA were set at 5.8 % and 15.8 %, respectively, as the upper limits of the normal reference interval in pregnant women...
January 1, 2018: Annals of Clinical Biochemistry
Hugh Owen Colhoun, Eileen P Treacy, Marguerite M MacMahon, Pauline M Rudd, Maria Fitzgibbon, Roisin O'Flaherty, Karolina Maria Stepien
BACKGROUND: Classical galactosaemia (OMIM 230400) is a rare disorder of carbohydrate metabolism caused by deficiency of the galactose-1-phosphate uridyltransferase enzyme. The pathophysiology of the long-term complications, mainly cognitive, neurological and female fertility problems, remains poorly understood. Current clinical methods of biochemical monitoring lack precision and individualisation with an identified need for improved biomarkers for this condition. METHODS: We report the development and detailed validation of an automated ultra-performance liquid chromatography (UPLC) N-glycan analytical method of high peak resolution applied to galactose incorporation into human serum IgG...
January 1, 2018: Annals of Clinical Biochemistry
David Ducroq, Annette Thomas
No abstract text is available yet for this article.
January 1, 2018: Annals of Clinical Biochemistry
Jonathan Middle
No abstract text is available yet for this article.
January 1, 2018: Annals of Clinical Biochemistry
John W Honour
No abstract text is available yet for this article.
January 1, 2018: Annals of Clinical Biochemistry
Milad Khedr, Anna M Milan, Andrew S Davison
No abstract text is available yet for this article.
January 1, 2018: Annals of Clinical Biochemistry
David J Marshall, Joanne E Adaway, Brian G Keevil
No abstract text is available yet for this article.
January 1, 2018: Annals of Clinical Biochemistry
Michael M Page, Mario Taranto, Duncan Ramsay, Greg van Schie, Paul Glendenning, Melissa Gillett, Samuel Vasikaran
OBJECTIVE: Primary aldosteronism is a curable cause of hypertension which can be treated surgically or medically depending on the findings of adrenal vein sampling (AVS) studies. AVS studies are technically demanding with a high failure rate in many centres. The use of intra-procedural cortisol measurement could improve the success rates of AVS but may be impracticable due to cost and effects on procedural duration. DESIGN: Retrospective review of the results of AVS procedures since commencement of point of care cortisol measurement using a novel single-use semi-quantitative measuring device for cortisol, the AVS Accuracy Kit (AAK)...
January 1, 2018: Annals of Clinical Biochemistry
Jean-Baptiste Delaye, Franck Patin, Emmanuelle Lagrue, Olivier Le Tilly, Clement Bruno, Marie-Laure Vuillaume, Martine Raynaud, Isabelle Benz-de Bretagne, Frederic Laumonnier, Patrick Vourc'h, Christian Andres, Helene Blasco
Objectives Autism Spectrum Disorders (ASD) and Intellectual Disability (ID) present a challenge for therapeutic and dietary management. We performed a re-analysis of plasma amino acid chromatography (AAC) of children with ASD (n=22) or ID (n=29) to search for a metabolic signature that can distinguish individuals with these disorders from controls (n=30). Methods We performed univariate and multivariate analysis using different machine learning strategies, from the raw data of the AAC. Finally, we analyzed the metabolic pathways associated with discriminant biomarkers...
January 1, 2018: Annals of Clinical Biochemistry
Julia S Kenkre, John H Bassett
The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining mineral homeostasis. During the bone remodelling cycle osteoclastic resorption is tightly coupled to osteoblastic bone formation. The remodelling cycle occurs within the Basic Multicellular Unit and comprises five co-ordinated steps; activation, resorption, reversal, formation and termination. These steps occur simultaneously but asynchronously at multiple different locations within the skeleton...
January 1, 2018: Annals of Clinical Biochemistry
Holly Emms, George Farah, Brian Shine, Christopher Boot, Barry Toole, Martin McFadden, Leo Lam, Zong-Quan Ou, Gerald A Woollard, Hima Madhavaram, Campbell Kyle, Ashley Grossman
Plasma metanephrines have become the biochemical test of choice for suspected phaeochromocytoma and paragangliomas (PPGL) in many institutions. We encountered two separate cases of significantly elevated plasma metanephrines in patients taking midodrine, a sympathomimetic drug used in the treatment of severe postural hypotension, in the absence of a diagnosis of PPGL. Upon stopping midodrine treatment, plasma metanephrine levels returned to normal in both patients. To explore the hypothesis that midodrine or its metabolite desglymidodrine might interfere with the metanephrines assay, we tested the interaction of midodrine with metanephrine assays from two different centres...
January 1, 2018: Annals of Clinical Biochemistry
Feng Wang, Jun Wang, Linlin Ju, Lin Chen, Weihua Cai, Jialin Yang
BACKGROUND: It has been reported that both of the miR-132/212 (micro-RNA) cluster members, miR-132 and miR-212, are downregulated in hepatocellular carcinoma (HCC). Nevertheless, the expression pattern and clinical utility of serum miR-132/212 in HCC are still unknown. METHODS: In this study, serum levels of miR-132 and miR-212 were measured in 80 HCC patients, 51 controls with chronic liver diseases (CLD) and 42 healthy volunteers by using quantitative real-time PCR (qPCR)...
January 1, 2018: Annals of Clinical Biochemistry
Karin Tanaka, Shu Meguro, Masami Tanaka, Junichiro Irie, Yoshifumi Saisho, Hiroshi Itoh
Background Glycated albumin (GA) reflects 2-3week glycemic controls, and as well as HbA1c, has been used as a glycemic control indicator. We presumed that GA also has seasonal variations and is related to temperature, similar to HbA1c. Methods The subjects were diabetic outpatients from April 2007 to March 2013. This resulted in the enrolment of 2246 subjects and the collection of a total of 53,968 measurements. Mean HbA1c, GA, and PG were calculated for each month over 6 years. The associations of the measures with each other and the average temperature for each month in Tokyo were using spearman rank correlation coefficients...
January 1, 2018: Annals of Clinical Biochemistry
Per Hyltoft Petersen, Flemming Lund, Callum G Fraser, Sverre Sandberg, György Sölétormos
Background Many clinical decisions are based on comparison of patient results with reference intervals. Therefore, an estimation of the analytical performance specifications for the quality that would be required to allow sharing common reference intervals is needed. The International Federation of Clinical Chemistry (IFCC) recommended a minimum of 120 reference individuals to establish reference intervals. This number implies a certain level of quality, which could then be used for defining analytical performance specifications as the maximum combination of analytical bias and imprecision required for sharing common reference intervals, the aim of this investigation...
January 1, 2018: Annals of Clinical Biochemistry
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