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Annals of Clinical Biochemistry

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https://www.readbyqxmd.com/read/27932670/annals-express-red-blood-cell-distribution-width-and-neutrophil-to-lymphocyte-ratio-are-associated-with-outcomes-of-adult-subarachnoid-hemorrhage-patients-admitted-to-intensive-care-unit
#1
Yuan-Lan Huang, Zhi-Jun Han, Zhi-De Hu
BACKGROUND: Red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been reported to be associated with outcomes of acute cerebral infarction. However, their prognostic value in patients with subarachnoid hemorrhage (SAH) remains largely unknown. The aim of this study was to investigate the prognostic value of RDW and NLR in SAH patients. METHODS: Medical records of adult SAH patients admitted to intensive care unit (ICU) were extracted from Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II, version 2...
December 8, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27932669/annals-express-quantification-of-the-steady-state-plasma-concentrations-of-clozapine-and-n-desmethylclozapine-in-japanese-patients-with-schizophrenia-using-a-novel-hplc-method-and-the-effects-of-cyps-and-abc-transporters-polymorphisms
#2
Yumiko Akamine, Yuka Sugawara-Kikuchi, Tsukasa Uno, Tetsuo Shimizu, Masatomo Miura
BACKGROUND: This study developed a novel high-performance liquid chromatography (HPLC) method for the simultaneous quantification of clozapine and its active metabolite, N-desmethylclozapine, in human plasma and investigated the effects of various factors, including genetic polymorphisms in cytochrome P450 (CYP) 2D6, CYP3A5, ABCB1, and ABCG2, on the steady-state plasma trough concentrations (C0) of clozapine and N-desmethylclozapine in Japanese patients with schizophrenia. METHODS: Forty-five patients had been receiving fixed doses of clozapine for at least 4 weeks...
December 8, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27923888/annals-express-attempted-suicide-by-ingestion-of-hair-dye-containing-p-phenylenediamine-a-case-report
#3
Lamis Beshir, Babiker Kaballo, Donald Young
Para-phenylenediamine (PPD) is widely used as a chemical in hair dyes and in combination with Henna. This dye is used to paint the body for decorative reasons, to speed the processing time of henna and intensify the results. PPD is quite used in the Middle East, North Africa and areas like India. Several reports have been published of fatal ingestion of hair dye containing para-phenylenediamine. Here we describe the case of a 14 year-old girl who ingested the compound but whose prompt treatment prevented her death...
December 5, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27856516/annals-express-effect-of-the-systemic-inflammatory-response-as-provoked-by-elective-orthopaedic-surgery-on-hba1c
#4
Andrew J Chadburn, Elizabeth Garman, Raad Abbas, Anu Modupe, Clare Ford, Osmond L Thomas, Sanjiv Chugh, Shreeram Deshpande, Rousseau Gama
BACKGROUND: In acutely ill patients with new onset hyperglycaemia, plasma glucose cannot reliably distinguish between stress hyperglycaemia and undiagnosed diabetes mellitus. We, therefore, investigated the diagnostic reliability of glycated haemoglobin (HbA1c) in acute illness by prospectively evaluating the effect of the systemic inflammatory response (SIR), as provoked by elective orthopaedic surgery, on HbA1c. METHODS: HbA1c and serum CRP concentrations were compared before and two days after elective knee or hip surgery in 30 patients without diabetes...
November 17, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27810997/annals-express-clinical-significance-of-gcf-sil-6r-and-calprotectin-to-evaluate-the-periodontal-inflammation
#5
Yukari Kajiura, Jung Hwan Lew, Takahisa Ikuta, Yasufumi Nishikawa, Jun-Ichi Kido, Toshihiko Nagata, Koji Naruishi
BACKGROUND: Periodontitis is a inflammatory disease. The aim of this study was to investigate whether soluble form of interleukin-6 receptor (sIL-6R) and calprotectin levels in gingival crevicular fluid (GCF) are useful bio-marker to evaluate the periodontitis. METHODS: At first, cross-sectional study was performed. A total of 34 periodontitis patients were enrolled and the GCF samples were collected from healthy and inflamed sites of periodontal pockets in each patient...
November 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27810996/annals-express-stability-of-ionized-calcium-measurements-at-concentrations-less-than-0-3-mmol-l-by-point-of-care-blood-gas-instruments-application-for-post-filter-calcium-quality-control-in-patients-with-citrate-anticoagulation-during-extracorporeal-circulation
#6
Maria Averina, Raymond Jakobsen
: BackgroundMeasurements of ionized calcium (Ca(2)(+)) at concentrations less than 0.3 mmol/L are required for post-filter control in patients that receive extracorporeal circulation with sodium citrate anticoagulation. This study evaluates the stability of the Ca(2)(+) measurements at such concentrations. MethodsThe stability of the Ca(2)(+) measurements was tested by measuring daily the external standard Qualicheck concentration 3 s7950, Radiometer (0.22-0.25 mmol/L) by blood gas instruments ABL800 and ABL90, Radiometer...
November 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27799298/annals-express-uptake-of-recommended-common-reference-intervals-for-chemical-pathology-in-australia
#7
Graham Jones, Sabrina Koetsier
BackgroundReference intervals are a vital part of reporting numerical pathology results. It is known however that variation in reference intervals between laboratories is common, even when analytical methods support common reference intervals. In response to this in Australia, the Australasian Association of Clinical Biochemists (AACB) together with the Royal College of Pathologists of Australasia (RCPA) published in 2014 a set of recommended common reference intervals for twelve common serum analytes (sodium, potassium, chloride, bicarbonate, creatinine male, creatinine female, calcium, calcium adjusted for albumin, phosphate, magnesium, lactate dehydrogenase, alkaline phosphatase, total protein)...
October 31, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27742851/annals-express-the-role-of-calculated-non-caeruloplasmin-bound-copper-in-wilson-s-disease
#8
Andrew Duncan, Calum Yacoubian, Robert Beetham, Anthony Catchpole, David Bullock
BACKGROUND: US and European guidelines suggest the use of calculated non-caeruloplasmin bound copper (free copper index) for the diagnosis and management of Wilson's Disease. However, there is concern that the required analytical measurements of caeruloplasmin and copper may not be sufficiently robust at the concentrations usually found. METHODS: Aliquots of six plasma specimens were sent to laboratories participating in the UK National External Quality Assessment Scheme for copper and caeruloplasmin...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27742850/annals-express-late-diagnosis-of-primary-hyperoxaluria-type-iii-a-case-report
#9
Emmanuel Richard, Jean-Marc Blouin, Jerome Harambat, Brigitte Llanas, Stephane Bouchet, Cecile Acquaviva, Renaud De la Faille
We report the case of a 78-year-old patient with late diagnosis of hyperoxaluria type III (PH3). He developed renal failure after nephrectomy for clear cell papillary renal carcinoma and complained of recurrent urolithiasis for some 30 years whose etiology was never identified. Biochemical laboratory investigations of urine and urolithiasis composition revealed marked hyperoxaluria but normal levels of urinary glyceric and glycolic acid as well as stones of idiopathic calcium-oxalate appearance. Furthermore, the dietary survey showed excessive consumption of food supplements containing massive amounts of oxalate precursors...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27742849/annals-express-the-prevalence-of-metabolic-syndrome-increases-with-serum-hs-crp-concentration-in-individuals-without-a-history-of-cardiovascular-disease-a-report-from-a-large-persian-cohort
#10
Seyyed Mohammad Reza Kazemi-Bajestani, Maryam Tayefi, Mahmoud Ebrahimi, Ali Reza Heidari-Bakavoli, Mohsen Moohebati, Seyyed Mohammad Reza Parizade, Habib-Allah Esmaeili, Gordon Ferns, Majid Ghayour-Mobarhan
BACKGROUND: Metabolic syndrome (MetS) is defined by a clustering of cardiovascular (CV) risk factors and is associated with a heightened inflammatory state. A raised serum high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation, is also known to associate with CV risk. We have investigated the relationship between the presence of MetS and serum hs-CRP concentration in a large representative Persian population cohort without a history of cardiovascular disease (CVD). METHODS: The MASHAD study population cohort comprised 9 778 subjects, who were recruited from the city of Mashhad, Iran, between 2007 and 2008...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27742848/annals-express-vitamin-d-binding-protein-as-it-is-understood-in-2016-is-it-a-critical-key-with-which-to-help-to-solve-the-calcitriol-conundrum
#11
Richard X Davey
BACKGROUND: The misnamed 'vitamin' D is actually the hormone calcitriol (1,25 dihydroxyhydroxyvitamin D). It has a central regulatory role in calcium metabolism, and more widely in the immune system. The prohormone calcifediol (25 hydroxyvitamin D) is more easily measured in the laboratory and is the analyte used in reference interval formulation. Being highly lipid soluble, both calcifediol and calcitriol travel in the bloodstream on carriage proteins, principally on vitamin D binding protein, DBP...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27705887/annals-express-chitotriosidase-enzyme-activity-is-this-a-possible-chronic-inflammation-marker-in-children-with-common-variable-immunodeficiency-and-early-atherosclerosis
#12
Elif Azarsız, Neslihan Karaca, Erturk Levent, Necil Kutukculer, Eser Sozmen
BACKGROUND: Common variable immunodeficiency (CVID) is a rare clinically symptomatic primary immunodeficiency disorder which manifests a wide variability of symptoms, complications. Atherosclerosis in CVID patients have not been investigated yet contrary to other severe clinical complications. We aimed to investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker in pediatric CVID patients. METHODS: CVID patients (n =24) and healthy controls (n = 23) evaluated for chitotriosidase activity with other inflammation markers (hsCRP, myeloperoxidase, serum amyloid A, ferritin), lipid profile and echocardiographic findings (carotid artery intima media thickness - cIMT, brachial artery flow-mediated vazodilatation - FMD%)...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27705886/annals-express-alcohol-consumption-reduces-hba1c-and-glycated-albumin-levels-but-not-1-5-anhydroglucitol
#13
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27705885/annals-express-the-pre-analytical-stability-of-glucagon-as-measured-by-lc-ms-ms-and-two-commercially-available-immunoassays
#14
Jaimini Cegla, Ben Jones, James Howard, Richard Kay, Colin S Creaser, Stephen R Bloom, Tricia Tan
BACKGROUND: One of the main challenges in the measurement of glucagon is the premise that it is unstable in human plasma. Traditionally, protease inhibitors have been used to prevent its degradation, however, their use is controversial. Here we investigated the optimal method of sample collection for glucagon, with measurement by liquid chromatography tandem mass spectrometry (LC-MS/MS) and two commercially available immunoassays. METHODS: Blood from healthy fasting volunteers (n=10) was processed under a variety of pre-analytical condition including collection in EDTA vs lithium heparin tubes and the addition of aprotinin and/or a DPPIV inhibitor...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27701066/annals-express-ferritin-and-iron-studies-in-anaemia-and-chronic-disease
#15
Yingying Peng, James Uprichard Uprichard
Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia (IDA) and the anaemia of chronic disease (ACD) are the two most common causes of anaemia worldwide; iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential, not only for diagnosis but also in guiding management. This review will primarily focus on IDA and ACD; however iron overload in anaemia will also be briefly discussed...
October 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27687084/assessment-of-a-semi-quantitative-screening-method-for-diagnosis-of-ethylene-glycol-poisoning
#16
Arun Sankaralingam, Annette Thomas, David R James, Anthony S Wierzbicki
BACKGROUND: Ethylene glycol poisoning remains a rare but important presentation to acute toxicology units. Guidelines recommended that ethylene glycol should be available as an 'urgent' test within 4 h, but these are difficult to deliver in practice. This study assessed a semi-quantitative enzymatic spectrophotometric assay for ethylene glycol compatible with automated platforms. METHODS: The ethylene glycol method was assessed in 21 samples from patients with an increased anion gap and metabolic acidosis not due to ethylene glycol ingestion, and seven samples known to contain ethylene glycol...
September 28, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27687083/annals-express-evaluation-of-reduced-centrifugation-time-and-higher-centrifugal-force-on-chemistry-and-immunochemistry-analytes-in-plasma-and-serum
#17
Mette Fogh Møller, Tove Rask Søndergaard, Helle Tanderup Kristensen, Anna-Marie Bloch Münster
BACKGROUND: Centrifugation of blood samples is an essential pre-analytical step in the clinical biochemistry laboratory. Centrifugation settings are often altered to optimize sample flow and turnaround time. Few studies have addressed the effect of altering centrifugation settings on analytical quality, and almost all studies have been done using collection tubes with gel separator. METHODS: In this study we compared a centrifugation time of 5 min at 3000 × g to a standard protocol of 10 min at 2200 × g...
September 28, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27687082/annals-express-elevated-levels-of-hypoxia-inducible-factor-1%C3%AE-in-patients-with-fracture-and-concomitant-traumatic-brain-injury
#18
Xiguang Sang, Zhiyong Wang, Tao Qin, Yonggang Li
BACKGROUND: Compelling evidence indicate that traumatic brain injury (TBI) is highly related to accelerated bone fracture repair, but the underlying mechanism still remains elusive. Fracture repair process relies greatly on the formation of new blood vessels in fracture site and angiogenic factors have been confirmed to be essential for the initiation and maintenance of the fracture healing. Hypoxia-inducible factor-1α (HIF-1α) was demonstrated to be a critical regulator of angiogenic-osteogenic coupling during bone development and regeneration...
September 28, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27687081/annals-express-falsely-elevated-serum-oestradiol-due-to-exemestane-therapy-a-case-report
#19
Sanja Mandic, Juergen Kratzsch, Dario Mandic, Zeljko Debeljak, Iva Lukic, Vesna Horvat, Alexander Gaudl, Vatroslav Seric
In this study we present a case of falsely elevated oestradiol (E2) concentration, determined by two immunoassays, in a breast cancer patient receiving exemestane therapy. The positive bias of immunochemical measurements was revealed using liquid chromatography tandem mass spectrometry (LC-MS/MS) which showed undetectable E2 concentration. The discrepancy is expected to be a consequence of the structural resemblance of E2 and exemestane sharing the same steroidal backbone. Inaccurate laboratory findings in therapy monitoring, as in this case, may lead to unnecessary changes of therapy...
September 28, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27687080/annals-express-natural-selection-the-evolution-of-diagnostic-criteria-for-gestational-diabetes
#20
Claire L Meek
Gestational diabetes (GDM) is a common pregnancy disorder which is generally managed with diet, exercise, metformin or insulin treatment and which usually resolves after delivery of the infant. Identifying and treating GDM improves maternal and fetal outcomes, and allows for health promotion to reduce the mother's risk of type 2 diabetes in later life. However, there remains considerable controversy about the optimal method of identification and diagnosis of women with GDM. The NICE-2015 diagnostic criteria (75g oral glucose tolerance test (OGTT) 0 hr ⩾5...
September 28, 2016: Annals of Clinical Biochemistry
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