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Annals of Clinical Biochemistry

Yachana Kataria
No abstract text is available yet for this article.
May 2017: Annals of Clinical Biochemistry
Graham Rd Jones, Jason Zy Chung
No abstract text is available yet for this article.
May 2017: Annals of Clinical Biochemistry
Flemming Lund, Per H Petersen, Callum G Fraser, György Sölétormos
No abstract text is available yet for this article.
May 2017: Annals of Clinical Biochemistry
Giles Aldworth
No abstract text is available yet for this article.
May 2017: Annals of Clinical Biochemistry
Nadia El-Farhan, D Aled Rees, Carol Evans
Cortisol is a steroid hormone produced in response to stress. It is essential for maintaining health and wellbeing and leads to significant morbidity when deficient or present in excess. It is lipophilic and is transported bound to cortisol-binding globulin (CBG) and albumin; a small fraction (∼10%) of total serum cortisol is unbound and biologically active. Serum cortisol assays measure total cortisol and their results can be misleading in patients with altered serum protein concentrations. Automated immunoassays are used to measure cortisol but lack specificity and show significant inter-assay differences...
May 2017: Annals of Clinical Biochemistry
Maria Averina, Raymond Jakobsen
Background Measurements of ionized calcium (Ca(2+)) at concentrations less than 0.3 mmol/L are required for postfilter control in patients who receive extracorporeal circulation with sodium citrate anticoagulation. This study evaluates the stability of the Ca(2+) measurements at such concentrations. Methods The stability of the Ca(2+) measurements was tested by measuring daily the external standard Qualicheck concentration 3 s7950, Radiometer (0.22-0.25 mmol/L) by blood gas instruments ABL800 and ABL90, Radiometer...
May 2017: Annals of Clinical Biochemistry
Graham Rd Jones, Sabrina Koetsier
Background Reference intervals are a vital part of reporting numerical pathology results. It is known, however, that variation in reference intervals between laboratories is common, even when analytical methods support common reference intervals. In response to this, in Australia, the Australasian Association of Clinical Biochemists together with the Royal College of Pathologists of Australasia published in 2014 a set of recommended common reference intervals for 11 common serum analytes (sodium, potassium, chloride, bicarbonate, creatinine male, creatinine female, calcium, calcium adjusted for albumin, phosphate, magnesium, lactate dehydrogenase, alkaline phosphatase and total protein)...
May 2017: Annals of Clinical Biochemistry
Emmanuel Richard, Jean-Marc Blouin, Jérome Harambat, Brigitte Llanas, Stéphane Bouchet, Cécile Acquaviva, Renaud de la Faille
We report the case of a 78-year-old patient with late diagnosis of hyperoxaluria type III (PH3). He developed renal failure after nephrectomy for clear cell papillary renal carcinoma and complained of recurrent urolithiasis for some 30 years, whose aetiology was never identified. Biochemical laboratory investigations of urine and urolithiasis composition revealed marked hyperoxaluria but normal concentrations of urinary glyceric and glycolic acid as well as stones of idiopathic calcium-oxalate appearance. Furthermore, the dietary survey showed excessive consumption of food supplements containing massive amounts of oxalate precursors...
May 2017: Annals of Clinical Biochemistry
Sanja Mandic, Jϋrgen Kratzsch, Dario Mandic, Zeljko Debeljak, Iva Lukic, Vesna Horvat, Alexander Gaudl, Vatroslav Seric
In this study, we present a case of falsely elevated oestradiol (E2) concentration, determined by two immunoassays, in a breast cancer patient receiving exemestane therapy. The positive bias of immunochemical measurements was revealed using liquid chromatography tandem mass spectrometry which showed undetectable E2 concentration. The discrepancy is expected to be a consequence of the structural resemblance of E2 and exemestane sharing the same steroidal backbone. Inaccurate laboratory findings in therapy monitoring, as in this case, may lead to unnecessary changes of therapy...
May 2017: Annals of Clinical Biochemistry
Sirazum M Choudhury, Emma L Williams, Sophie C Barnes, Jamshid Alaghband-Zadeh, Tricia M Tan, Jaimini Cegla
Background Using an online survey, we collected data to present a picture of how clinical authorization is performed in the UK. Methods A 21-question survey was uploaded to , and responses were invited via the mail base of the Association for Clinical Biochemistry and Laboratory Medicine. The questionnaire examined the intensity and function of the duty biochemist role and how different types of authorization are used to handle and release results. Results Of 70 responses received, 60 were suitable for analysis...
May 2017: Annals of Clinical Biochemistry
Nuthar Jassam, Cas Weykamp, Annette Thomas, Sandra Secchiero, Laura Sciacovelli, Mario Plebani, Marc Thelen, Christa Cobbaert, Carmen Perich, Carmen Ricós, Faria A Paula, Julian H Barth
Introduction Reliable serum creatinine measurements are of vital importance for the correct classification of chronic kidney disease and early identification of kidney injury. The National Kidney Disease Education Programme working group and other groups have defined clinically acceptable analytical limits for creatinine methods. The aim of this study was to re-evaluate the performance of routine creatinine methods in the light of these defined limits so as to assess their suitability for clinical practice...
May 2017: Annals of Clinical Biochemistry
Guowei Zhang, Mochao Xiao, Lili Zhang, Yue Zhao, Qinghui Yang
Objective Chemerin, a newly discovered adipokine, is correlated with hypertension, diabetes and coronary heart disease. The aim of this study is to investigate the association of serum chemerin concentrations with the presence of atrial fibrillation. Methods Serum chemerin concentrations were determined in 256 patients with atrial fibrillation and 146 healthy subjects. Atrial fibrillation patients were then divided into paroxysmal, persistent and permanent atrial fibrillation. Results Serum chemerin concentrations were significantly higher in atrial fibrillation patients compared with healthy controls...
May 2017: Annals of Clinical Biochemistry
Artur Słomka, Milena Świtońska, Władysław Sinkiewicz, Ewa Żekanowska
Background Although the role of microparticles was recently implicated in stroke pathophysiology, the association between microparticles and inflammation is still not fully understood. The aim of this cohort study of 66 patients was to assess a relation between haemostatic factors, C-reactive protein and clinical outcome of ischaemic stroke. Methods Plasma microparticles procoagulant activity, concentrations of tissue factor-bearing microparticles, tissue factor and tissue factor pathway inhibitor in ischaemic stroke patients were determined with enzyme-linked immunosorbent assays at the time of initial diagnosis, along with serum C-reactive protein concentrations...
May 2017: Annals of Clinical Biochemistry
Anjly Jain, Nandini Rao, Mahtab Sharifi, Nirav Bhatt, Payal Patel, Divyabala Nirmal, Jham Want Persaud, Devaki R Nair
Background A 'one stop shop' model for multifactorial risk factor management in a culturally sensitive environment may improve cardiovascular disease and diabetes prevention. A full biochemical profile for cardiovascular disease risk assessment includes a lipid profile, glucose, glycated haemoglobin and urine albumin creatinine ratio measurements. This may require the use of more than one point of care testing instrument. Methods Individuals who attended a community cardiovascular disease risk screening or an audit programme of the diabetic care pathway in the community were sampled...
May 2017: Annals of Clinical Biochemistry
Robyn L Shea, Jonathan D Berg
Introduction Our dried blood spot vitamin D testing service enables members of the public to assess their vitamin D status. Vitamin D has become popular with the media and the general public. We noticed that our direct access service had a higher rate of high to toxic 25-hydroxyvitamin D levels compared with our GP population and we wanted to know why. Methods Between January 2013 and September 2015 we contacted all direct access users who had 25-hydroxyvitamin D >220 nmol/L measured using LC/MS/MS. We investigated the amount, type and length of supplementation used and whether or not users were medically supervised...
May 2017: Annals of Clinical Biochemistry
Chris F Harrington, Craig McKibbin, Monika Rahanu, David Langton, Andrew Taylor
Background Patients with metal-on-metal hip replacements require testing for cobalt and chromium. There may also be a need to test for titanium, which is used in the construction of the femoral stem in total hip replacements. It is not possible to use quadrupole inductively coupled plasma mass spectrometry due to interferences. Methods Titanium was measured using inductively coupled plasma optical emission spectroscopy using the emission line at 336.1 nm and Y (internal standard) at 371.0 nm. Internal quality control materials were prepared for blood and serum and concentrations assigned using a sector field-inductively coupled plasma mass spectrometer...
May 2017: Annals of Clinical Biochemistry
Saima Naz, Farkhanda Ghafoor, Imran Akhtar Iqbal
Background Myeloperoxidase has shown potential as a marker for prognosis of coronary artery disease, but presently little is known about preanalytical handling of samples for quantifying myeloperoxidase. The present study was conducted to evaluate the effect of collection tube and freeze-thaw cycles on myeloperoxidase concentrations. Methods Acute coronary syndrome patients ( n = 88) were enrolled after obtaining written informed consent from coronary care unit of a tertiary care hospital (January 2012-June 2014)...
May 2017: Annals of Clinical Biochemistry
Jaimini Cegla, Ben J Jones, James Howard, Richard Kay, Colin S Creaser, Stephen R Bloom, Tricia M Tan
Background One of the main challenges in the measurement of glucagon is the premise that it is unstable in human plasma. Traditionally, protease inhibitors have been used to prevent its degradation; however, their use is controversial. Here, we investigated the optimal method of sample collection for glucagon, with measurement by liquid chromatography tandem mass spectrometry (LC-MS/MS) and two commercially available immunoassays. Methods Blood from healthy fasting volunteers (n = 10) was processed under a variety of preanalytical conditions including collection in EDTA vs...
March 2017: Annals of Clinical Biochemistry
Jacqueline Woolf, Joanne T Marsden, Timothy Degg, Sharon Whatley, Paul Reed, Nadia Brazil, M Felicity Stewart, Michael Badminton
The porphyrias are disorders of haem biosynthesis which present with acute neurovisceral attacks or disorders of sun-exposed skin. Acute attacks occur mainly in adults and comprise severe abdominal pain, nausea, vomiting, autonomic disturbance, central nervous system involvement and peripheral motor neuropathy. Cutaneous porphyrias can be acute or chronic presenting at various ages. Timely diagnosis depends on clinical suspicion leading to referral of appropriate samples for screening by reliable biochemical methods...
March 2017: Annals of Clinical Biochemistry
Shouzhen Chen, Mei Jiang, Tao Ding, Junmei Wang, Ping Long
Background Calprotectin is an antimicrobial, calcium and zinc-binding heterocomplex protein and has been proposed as a marker to rule out inflammatory conditions. The aim of this study was to evaluate the role of calprotectin in the diagnosis of polycystic ovary syndrome and to investigate the association between calprotectin and insulin resistance. Methods A total of 41 females with polycystic ovary syndrome and 54 age-matched without polycystic ovary syndrome were eligible for the study. Serum concentration of calprotectin was determined using enzyme-linked immunosorbent assay...
March 2017: Annals of Clinical Biochemistry
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