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Scandinavian Journal of Immunology

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https://www.readbyqxmd.com/read/27992958/impaired-akt-phosphorylation-in-monocytes-of-patients-with-rheumatoid-arthritis
#1
Krista Kuuliala, Antti Kuuliala, Mari Hämäläinen, Riitta Koivuniemi, Hannu Kautiainen, Eeva Moilanen, Heikki Repo, Marjatta Leirisalo-Repo
It has been proposed that the Akt kinase pathway provides a regulatory mechanism to limit the inflammatory response. We examined the activation of Akt upon LPS challenge in monocytes of patients with rheumatoid arthritis (RA), and correlated it with disease activity. Twelve subjects with recent-onset, DMARD-naïve RA, thirteen patients with chronic, DMARD therapy -nonresponding RA and 27 healthy volunteers provided whole blood samples for phosphospecific flow cytometric measurement of unstimulated and LPS-stimulated Akt phosphorylation at serine 473 in monocytes, determined in relative fluorescence units (RFU)...
December 19, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27943420/association-between-tnf-%C3%AE-promoter-308-a-g-polymorphism-and-systemic-lupus-erythematosus-susceptibility-a-case-control-study-and-meta-analysis
#2
Zu-Cheng Yang, Fen Xu, Min Tang, Xia Xiong
The tumor necrosis factor-α (TNF-α) promoter -308 A/G polymorphism plays an important role in the etiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF-α -308 A/G and SLE risk. However, results were inconsistent. A case-control study was carried out to explore the association between TNF-α -308 A/G and the SLE risk in a Chinese Han population. Meta-analysis combining present with previous studies were conducted to further explore the association. Our case-control study included 556 SLE patients along with 570 matched healthy controls...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27943385/m2000-%C3%AE-d-mannuronic-acid-as-a-novel-antagonist-for-blocking-the-tlr2-and-tlr4-downstream-signaling-pathway
#3
Somaye Aletaha, Vahid Asgary, Leila Haddad, Maryam Roozbehkia, Reza Ahangari Cohan, Mahdi Mahmoudi, Abbas Mirshafiey
To date, selective blockade of Toll-like receptor (TLR) signaling have been developed as a new approach for treatment many inflammatory diseases. Since β-D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several experimental models, we investigated the antagonistic effects of M2000 on TLR2 and TLR4 downstream signaling transduction pathway in human embryonic kidney (HEK) 293 cell lines overexpressing TLR2/CD14 and the TLR4/MD2/CD14 complex, respectively. M2000 effectively inhibited mRNA expression of MyD88 and p65, major subunit of nuclear factor-κB, in HEK293 cells stimulated by Lipoteichoic acid (LTA, a TLR2 agonist) and Lipopolysaccharide (LPS, a TLR4 agonist) with no evidence of cytotoxicity...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27943380/in-vitro-monocyte-il-6-secretion-levels-following-stimulation-with-autologous-spheroids-derived-from-tumor-or-benign-mucosa-predict-long-term-survival-in-head-and-neck-squamous-cell-carcinoma-patients
#4
Hans Jorgen Aarstad, Helene Hersvik Aarstad, Olav Karsten Vintermyr, Kenneth Wilfried Kross, Stein Lybak, John-Helge Heimdal
MCP-1/IL-6 in vitro monocyte secretion upon co-culture with autologous fragment spheroids was studied in relation to patient five- and 10-year overall survival rates in Head and Neck Squamous Cell Carcinoma (HNSCC) patients (N=65) diagnosed between 1998 and 2005, nine of whom had an HPV tumor infection. The spheroids were harvested from malignant or benign tissue during primary surgery. Two weeks following surgery, freshly isolated autologous monocytes and benign or malignant spheroids were co-cultured 24 hours in vitro...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27943374/expression-of-toll-like-receptors-in-peripheral-blood-mononuclear-cells-of-patients-with-primary-sj%C3%A3-gren-s-syndrome
#5
Marie Karlsen, Kjerstin Jakobsen, Roland Jonsson, Daniel Hammenfors, Torbjørn Hansen, Silke Appel
Toll-like receptors (TLR) are pattern-recognition receptors important for the detection of pathogen-associated molecular patterns. They are localized on cellular membranes, either on the cell surface or the endosomes. Primary Sjögren's syndrome (pSS) is a systemic rheumatic autoimmune disease characterized by lymphocytic infiltrations in exocrine glands resulting in dry eyes and mouth. In a majority of patients, autoantibodies against Ro/SSA and/or La/SSB are present. Here we analyzed mRNA levels of TLR1-10 and protein expression levels of most of them in human peripheral blood mononuclear cells from 20 pSS patients and 20 healthy controls...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27943367/analysis-of-mir-146a-and-mir-142-3p-as-potential-markers-of-freshly-isolated-or-in-vitro-expanded-human-treg-cells
#6
Kim Holmstrøm, Anders Elm Pedersen, Monika Gad
Regulatory CD4+ T cells (Tregs) are pivotal for prevention of autoimmunity. The use of Tregs is therefore of increasing interest in in vitro drug screening assays as well as for a cytotherapy per se against autoimmune disorders. For both purposes, in vitro expansion of peripheral blood Tregs is necessary and there is an increasing need to identify novel markers that can discriminate natural thymic derived Tregs (tTregs) from other T cell subsets and ideally, such markers should be stably expressed during in vitro expansion procedures...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27943364/the-inflammation-induced-by-lipopolysaccharide-can-be-mitigated-by-short-chain-fatty-acid-butyrate-through-up-regulation-of-il-10-in-septic-shock
#7
Fangyan Wang, Jiaming Liu, Tingting Wong, Kaiyi Shen, Zhisong Chen, Ying Yu, Qiong Huang, Guocan Wang, Zhanguo Liu, Shengwei Jin
Short chain fatty acids (SCFAs) with the anti-inflammatory capacity are produced by intestinal bacteria, however, their effect on the acute systematical inflammation remains unclear. The current study aimed to investigate the effects of SCFAs, acetate, propionate and butyrate, on septic shock and the underlying mechanism. The LPS-induced septic model was used to evaluate the function of SCFAs by survival rate observation. Only butyrate, but not acetate or propionate, significantly decrease the mortality of septic mice...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27896842/il-12b-gene-polymorphisms-and-il-12-p70-serum-levels-among-patients-with-rheumatoid-arthritis
#8
A Paradowska-Gorycka, A Sowinska, B Stypińska, E Haladyj, A Pawlik, K Romanowska-Próchnicka, M Olesinska
OBJECTIVES: Rheumatoid arthritis (RA) is one of the autoimmune diseases, where different polymorphisms in cytokine genes play a pathogenic role. IL-12 is now recognized as a critical cytokine in terms of regulating the balance between Th1 and Th2 cells. We investigated the role of single-nucleotide polymorphisms (SNPs) (rs3212227 (A/C) and rs17860508 (CTCTAA/GC)) of the IL-12B gene in the genetic susceptibility to RA and in the severity of the disease. METHODS: Six hundred and thirty four Caucasian RA patients and 341 healthy matched controls were studied using PCR-RFLP method and High-resolution melting analysis...
November 29, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27896837/cd6-and-linker-of-activated-t-cells-are-potential-interaction-partners-for-t-cell-specific-adaptor-protein
#9
Cecilie Dahl Hem, Marianne Ekornhol, Stine Granum, Vibeke Sundvold-Gjerstad, Anne Spurkland
The T cell specific adaptor protein (TSAd) contains several protein interaction domains, and is merging as a modulator of T cell activation. Several interaction partners for the TSAd proline rich region and phosphotyrosines have been identified, including the Src and Tec family kinases Lymphocyte specific protein tyrosine kinase (Lck) and Interleukin 2-Inducible T-cell kinase (Itk). Via its Src homology 2 (SH2) domain, TSAd may thus function as a link between these enzymes and other signaling molecules. However, few binding partners to the TSAd SH2 domain in T cells are hitherto known...
November 29, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27896829/immunomodulatory-and-immunosuppressive-roles-of-1%C3%AE-25-oh-2d3-in-autoimmune-diseases
#10
REVIEW
Hussaini Alhassan Mohammed, Ali Akbar Saboor-Yaraghi, Abbas Mirshafiey, Haumayon Vahedi, Mohammad Reza Shiri-Shahsavar, Ateke Mousavi Nasl Khameneh
BACKGROUND: Autoimmune diseases are pathological conditions characterized by abnormal. responses, accompanied by auto-antibodies to self-molecules. The roles vitamin D in autoimmune diseases has increased significantly in the recent past from its functions in calcium and phosphate homeostasis, it is now involved in the regulations and proliferations of Th1 and Th17 lymphocyte. 1α,25(OH)2D3 in very important in ameliorations of inflammatory disorders arising from autoimmune diseases, but the mechanism by which this is done is still a bone of contentions...
November 29, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27885703/immunological-tolerance-part-i-of-a-report-of-a-workshop-on-foundational-concepts-of-immune-regulation
#11
Colin C Anderson, Peter Bretscher, Alexandre Corthay, Zlatko Dembic, Calliopi Havele, Zoltan A Nagy, Inger Øynebråten
This report, the first of two, arose from a one-week workshop directed at discussing concepts of immune regulation, and focuses on immunological tolerance. We first outline the major ideas we thought sufficiently plausible to provide a context for discussing more controversial issues around tolerance. We then report on our discussion of different experiments that appear paradoxical in terms of the different, contemporary models of CD4 T cell inactivation/activation, and how such observations might be resolved in terms of insights provided by these contemporary models...
November 25, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27862137/t-cell-responses-and-regulation-and-the-impact-of-in-vitro-il-10-and-tgf-%C3%AE-modulation-during-treatment-of-active-tuberculosis
#12
Siri L Feruglio, Dag Kvale, Anne Ma Dyrhol-Riise
Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defense mechanism. In the present study we investigated T cell responses and regulation in active TB patients with drug-sensitive Mtb (n=18) during 24 weeks of efficient anti-TB therapy. T cell activation, differentiation, regulatory T cell (Treg) subsets, Mtb induced T cell proliferation and in vitro IL-10 and TGF-β modulation were analysed by flow cytometry at baseline and after 8 and 24 weeks of therapy, while soluble cytokines in culture supernatants were analysed by a 9-plex Luminex assay...
November 18, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27864994/serum-spd-l1-upregulated-in-sepsis-may-reflect-disease-severity-and-clinical-outcomes-in-septic-patients
#13
Minlong Liu, Xiaoling Zhang, Haiyan Chen, Guoen Wang, Jun Zhang, Peng Dong, Yuanyuan Liu, Shan An, Li Wang
we aimed to find the correlation between serum sPD-L1 (soluble programmed cell death L-1 ligand) and sepsis. Totally 91 consecutive patients with sepsis were performed in a 15-bed medical intensive care unit (ICU) of the second affiliated hospital, Xi'an Jiaotong University in Xi'an, China, between February 2015 and May 2016. Healthy controls (HC) consisted of 29 healthy volunteer. Baseline demographic data were recorded. Blood samples were collected through an indwelling central venous or by peripheral venipuncture...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27864993/thyrotropin-alters-t-cell-development-in-the-thymus-in-subclinical-hypothyroidism-mouse-model
#14
Kunpeng Wu, Meng Zhao, Chunyan Ma, Haiqing Zhang, Xiaojing Liu, Lingyan Zhou, Jiajun Zhao, Ling Gao, Dan Wang
Subclinical hypothyroidism (SCH) is highly prevalent in the general population and is associated with potential deleterious effects. Although developing T cells express thyroid stimulating hormone receptor (TSH-R), the changes of T cell development in thymus in SCH have not been fully clarified. SCH mouse model, which is characterized by elevated serum TSH but similar thyroid hormone levels, were used to study the role of TSH in T cell development. Thymus weight of SCH mice increased 18% compared with controls...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27864990/the-clinical-relevance-of-anti-fibrillarin-anti-u3-rnp-autoantibodies-in-systemic-sclerosis
#15
F Tall, M Dechomet, S Riviere, V Cottin, E Ballot, K P Tiev, R Montin, C Morin, Y Chantran, C Grange, D Jullien, J Ninet, P Chretien, J Cabane, N Fabien, C Johanet
OBJECTIVES: Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of anti-fibrillarin autoantibodies (AFA) in patients with SSc. METHODS: The clinical features of 37 SSc patients positive for AFA (AFA+) and 139 SSc patients without AFA (AFA-) were collected retrospectively from medical records to enable a comparison between AFA- and AFA+ patients...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27864913/human-secretory-igm-antibodies-activate-human-complement-and-offer-protection-at-mucosal-surface
#16
Terje E Michaelsen, Sidsel Emilsen, Randi H Sandin, Beathe Kiland Granerud, Diane Bratlie, Oistein Ihle, Inger Sandlie
IgM molecules circulate in serum as large polymers, mainly pentamers, which can be transported by the poly-Ig receptor (pIgR) across epithelial cells to mucosal surfaces and released as secretory IgM (SIgM). The mucosal SIgM molecules have non-covalently attached secretory component (SC), which is the extracellular part of pIgR which is cleaved from the epithelial cell membrane. Serum IgM antibodies do not contain SC, and have previously been shown to make a conformational change from "a star" to a "staple" conformation upon reaction with antigens on a cell surface, enabling them to activate complement...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27862144/approach-to-the-management-of-autoimmunity-in-primary-immunodeficiency
#17
REVIEW
Gholamreza Azizi, Vahid Ziaee, Marzieh Tavakol, Tina Alinia, Reza Yazdai, Hamed Mohammadi, Hassan Abolhassani, Asghar Aghamohammadi
Primary immunodeficiency diseases (PIDs) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non-infectious complications, particularly autoimmunity. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and leads to difficulty in the management of autoimmune complications in PID patients. Therefore, management of autoimmunity in patients with PID requires special considerations because dysregulations and dysfunctions of the immune system along with persistent inflammation, impair the process of diagnosis and treatment...
November 8, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27808429/equine-airway-mast-cells-are-sensitive-to-cell-death-induced-by-lysosomotropic-agents
#18
Sara Wernersson, Miia Riihimäki, Gunnar Pejler, Ida Waern
Mast cells are known for their detrimental effects in various inflammatory conditions. Regimens that induce selective mast cell apoptosis may therefore be of therapeutic significance. Earlier studies have demonstrated that murine and human cultured mast cells are highly sensitive to apoptosis induced by the lysosomotropic agent LeuLeuOMe (LLME). However, the efficacy of lysosomotropic agents for inducing apoptosis of in vivo-derived airway mast cells, and the impact on mast cells in other species have not been assessed...
November 3, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27783847/participation-of-tlr2-and-tlr4-in-cytokines-production-by-patients-with-symptomatic-and-asymptomatic-chronic-chagas-disease
#19
Laura Denise Mendes da Silva, Mariana Gatto, Mariana Miziara de Abreu Teodoro, Marjorie de Assis Golim, Érika Alessandra Pelisson Nunes da Costa, Francilene Capel Tavares Carvalho, Daniela Ramos Rodrigues, Paulo Câmara Marques Pereira, Ângela Maria Victoriano de Campos Soares, Sueli Aparecida Calvi
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi is a serious public health issue. Its evolution involves an acute stage, characterized by no specific symptoms, and the chronic stage during most individuals are asymptomatic, but about 30 to 40% of them become symptomatic presenting the cardiac or digestive disease. Host immune response mechanisms involved in symptomatic or asymptomatic chronic disease are not fully understood. The pro-inflammatory cytokines are crucial in host resistance. However, a fine control of this inflammatory process, by action of anti-inflammatory cytokines, is necessary to avoid tissue injury...
October 26, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28025871/editorial-per-brandtzaeg-in-memoriam
#20
EDITORIAL
R Jonsson
No abstract text is available yet for this article.
December 2016: Scandinavian Journal of Immunology
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