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Scandinavian Journal of Immunology

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https://www.readbyqxmd.com/read/29125655/25-hydroxyvitamin-d-autoantigenic-and-total-antibody-concentrations-results-from-a-danish-case-control-study-of-newly-diagnosed-patients-with-childhood-type-1-diabetes-and-their-healthy-siblings
#1
Steffen Ullitz Thorsen, Christian B Pipper, Jesper Johannesen, Henrik Bindesbøl Mortensen, Flemming Pociot, Jannet Svensson
BACKGROUND: B cells have recently entered the stage as an important accessory player in type 1 diabetes (T1D) etiopathogenesis. Experimental studies suggest regulatory functions of vitamin D on B cells. However, only a few human studies, with considerable methodological limitations, have been conducted within this field. OBJECTIVE: Our objective was to investigate if higher 25-hydroxyvitamin D (25(OH)D) concentrations were inversely associated with β-cell autoantigens glutamic acid decarboxylase (isoform 65) (GADA) and insulinoma associated antigen-2A (IA-2A)...
November 10, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29121412/galectin-3-a-potential-therapeutic-target-for-rheumatoid-arthritis
#2
LETTER
Qiang Xie, Ming Ni, Shi-Cun Wang
Recently, we read with great interest the article by Issa, et al., who showed that baseline galectin-3 was significantly increased in anti-CCP positive rheumatoid arthritis (RA) patients when compared to anti-CCP negative patients and healthy controls [1]. Moreover, experssion of galectin-3 correlated with baseline smoking, anti-CCP, and with MRI erosion score after 1 year of follow-up. These data indicated that galectin-3 is closely linked to autoimmunity in RA, and may play an important role in the pathogenesis of RA...
November 9, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29119640/il-23-actived-%C3%AE-%C3%AE-t-cells-affect-th17-cells-and-regulatory-t-cells-by-secreting-il-21-in-children-with-primary-nephrotic-syndrome
#3
Li Zhang, Junli Yan, Baohui Yang, Gaofu Zhang, Mo Wang, Shifang Dong, Wei Liu, Haiping Yang, Qiu Li
OBJECTIVE: This study (1) analyzed the percentage of γδ T cells, γδ T cell subsets, Th17 cells, and regulatory T cells (Treg cells), and (2) determined the role of IL-23 in primary nephrotic syndrome (PNS) patients with active disease and in remission. MATERIALS AND METHODS: Eighty-four PNS patients and 51 healthy age-matched controls were included in this study. The percentage of γδ T cells, γδ T cell subsets, Th17 cells, and Treg cells in peripheral blood mononuclear cells (PBMCs) were analyzed by fluorescence-activated cell sorting...
November 9, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29119580/comment-on-phenotypic-prenatal-diagnosis-of-chronic-granulomatous-disease-cgd-a-useful-tool-in-the-absence-of-molecular-diagnosis
#4
LETTER
Peter E Newburger
I read with interest the report by Kulkarni, Gupta, and Madkaikar,[1] cited above. It was good to see that modern technology of flow cytometry could be applied to the phenotypic prenatal diagnosis of CGD. However, I disagree with their assessment that flow cytometry for dihydrorhodamine fluorescence is preferable to histochemical detection of nitroblue tetrazolium (NBT) reduction. This article is protected by copyright. All rights reserved.
November 9, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29106704/positive-krec-newborn-screening-in-a-neonate-with-intrauterine-exposure-to-rituximab
#5
LETTER
Renate Krüger, Stephan Borte, Katharina von Weizsäcker, Volker Wahn, Cornelia Feiterna-Sperling
Neonates with severe T- and/or B-lymphopenia can be identified within the first week of life using T-cell-receptor-excision circles (TREC) and kappa-deleting-recombination-excision circles (KREC) screening of dried blood spots (DBS). Newborns exposed to rituximab (RTX; anti-CD20-antibody) due to maternal therapy during pregnancy may be identified as immunodeficient with B-cell lymphopenia because of drug induced transient depletion of B cells. We present a child with intrauterine exposure to RTX up to 30 weeks of gestation...
November 6, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29105157/reduced-numbers-of-mature-medullary-thymic-epithelial-cells-in-skg-mice
#6
Robby Engelmann, Andra Biemelt, Anja Johl, Daniela Kuthning, Brigitte Müller-Hilke
Attenuated T cell receptor (TCR) signaling contributes to the susceptibility for autoimmunity as shown via mutants of PTPN22 and Zap70 genes. We here set out to investigate the effect of an attenuated TCR signal on the composition of the thymic epithelial cell (TEC) compartment. To that extent, we combined flow cytometry and histology and compared the TEC subpopulations of Zap70 wild type with SKG mutant mice. We found an increased cortical TEC compartment in SKG thymi at the expense of reduced numbers of mature medullary TECs and a 4...
November 3, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29077981/tissue-specific-differences-in-immune-cell-subsets-located-in-the-naso-oropharyngeal-associated-lymphoid-tissues
#7
Maria Bankvall, Mats Jontell, Agnes Wold, Sofia Östman
Defining the immune cells within the naso-oropharyngeal-associated lymphoid tissues would promote the development of efficient oral and nasal delivered immunotherapies. The aim was to compare murine antigen-presenting cells (APCs) and T-cell subsets in the nose-associated lymphoid tissues (NALT), cervical lymph nodes (CLN), mesenteric lymph nodes (MLN) and peripheral lymph nodes (PLN) using flow cytometry and in vitro proliferation assays. Overall, the NALT contained a higher proportion of APCs and a lower proportion of T cells compared to the CLN, MLN, and PLN...
October 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29072325/patients-with-primary-sj%C3%A3-gren-s-syndrome-have-alterations-in-absolute-quantities-of-specific-peripheral-leukocyte-populations
#8
Richard Davies, Daniel Hammenfors, Brith Bergum, Kjerstin Jakobsen, Magne Solheim, Petra Vogelsang, Johan G Brun, Yenan Bryceson, Roland Jonsson, Silke Appel
An accurate dissection of peripheral blood enumeration is lacking in primary Sjögren's syndrome. The purpose of this study was to quantify different leukocyte populations in peripheral blood of patients with pSS. Numbers of specific leukocyte subsets were determined in 86 pSS patients and 74 healthy donors quantifying 21 distinct subtypes by flow cytometry. Subgroups of pSS patients were stratified based on presence of extraglandular manifestations (EGM) and SSA/SSB autoantibodies. Overall, pSS patients manifested decreased lymphocyte subpopulations compared to healthy donors...
October 26, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29063637/phenotypic-prenatal-diagnosis-of-chronic-granulomatous-disease-cgd-a-useful-tool-in-the-absence-of-molecular-diagnosis
#9
Manasi Kulkarni, Maya Gupta, Manisha Madkaikar
Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency disorder affecting the microbicidal function of the phagocytes. It is characterized by susceptibility to recurrent infections leading to significant morbidity and mortality. Antibacterial and antifungal prophylaxis though has significantly reduced the rate and severity of the infections; the breakthrough infections still remain a challenge. Currently allogenic hematopoietic stem cell transplantation is the only curative option which is very expensive and unavailable for many due to lack of suitable donor...
October 24, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29063635/immunogenicity-of-a-glycoconjugate-from-hydrazine-detoxified-lipopolysaccharide-of-vibrio-cholerae-o139
#10
Anna Fleischhackerová-Slimáková, Jana Korcová, Slavomír Bystrický
A glycoconjugate (dLPS-CBSA) from hydrazine-detoxified lipopolysaccharide of Vibrio cholerae O139 and BSA was used for immunization of Balb/c mice. The immunogenicity (concentration of induced IgG antibodies) of the conjugate was determined by enzyme-linked immunosorbent assay. The highest level of lipopolysaccharide-specific IgGs were found in sera collected two weeks after the third immunization. Both IgM and IgG antibodies present in the anti V. cholerae O139-specific sera showed long-lasting vibriocidal activity...
October 24, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29032575/decreased-expression-of-ifng-as1-ifng-and-il-1b-inflammatory-genes-in-medicated-schizophrenia-and-bipolar-patients
#11
Hannaneh Ghafelehbashi, Majid Pahlevan Kakhki, Lara Kular, Sahar Moghbelinejad, Seyyed Hossein Ghafelehbashi
Although aberrant expression of cytokines such as IL-1B and IFNG in blood from psychiatric patients supports a role of inflammation in the pathogenesis of disease, little is known about mechanisms underlying their regulation. We aimed to evaluate the putative role of IFNG-AS1 long non-coding RNA (lncRNA) in controlling of IFNG locus in schizophrenia (SZ) and Bipolar (BP) patients. We analyzed the expression levels of IFNG-AS1 long non-coding RNA, and IFNG and IL-1B mRNAs in blood cells from 27 SZ and 30 BP medicated patients and in 32 healthy controls...
October 15, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28990250/galectin-3-is-persistently-increased-in-early-rheumatoid-arthritis-ra-and-associates-with-anti-ccp-seropositivity-and-mri-bony-lesions-while-early-fibrosis-markers-correlate-with-disease-activity
#12
Saida Farah Issa, Anne Friesgaard Christensen, Hanne M Lindegaard, Merete L Hetland, Kim Hørslev-Petersen, Kristian Stengaard-Pedersen, Bo Jannik Ejbjerg, Tine Lottenburger, Torkell Ellingsen, Jens Kristian Pedersen, Kirsten Junker, Anders Svendsen, Ulrik Tarp, Mikkel Østergaard, Peter Junker
Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin-3 in patients with newly diagnosed RA and associations with disease profile, Magnetic Resonance Imaging (MRI) findings and seromarkers of synovial matrix inflammation. One hundred and sixty DMARD naïve patients newly diagnosed with RA were included (CIMESTRA study). Clinical, serological and imaging data were recorded before treatment and at 6 weeks, 3 and 12 months...
October 9, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28960415/thymic-atrophy-experimental-studies-and-therapeutic-interventions
#13
REVIEW
S Majumdar, D Nandi
The thymus is essential for T cell development and maturation. It is extremely sensitive to atrophy, wherein loss in cellularity of the thymus and/or disruption of the thymic architecture occur. This may lead to lower naïve T cell output and limited TCR diversity. Thymic atrophy is often associated with ageing. What is less appreciated is that proper functioning of the thymus is critical for reduction in morbidity and mortality associated with various clinical conditions including infections and transplantation...
September 28, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28960399/role-of-intracystic-cytokines-and-nitric-oxide-in-ovarian-neoplasms
#14
A Martins-Filho, M P Jammal, D C Micheli, B M Tavares-Murta, R M Etchebehere, E F C Murta, R S Nomelini
The development of new biomarkers for the diagnosis and prognosis of ovarian cancer may provide an opportunity for new therapies. In this study, we aimed to compare cytokines (interleukin [IL]-2, IL-5, IL-6, IL-8, IL-10 and tumour necrosis factor [TNF]-α) and nitric oxide (NO) metabolite levels in non-neoplastic tumours, benign primary ovarian tumours and malignant primary ovarian neoplasms. The secondary aim was to relate cytokine and intracystic NO metabolite levels to clinical, laboratory and pathologic characteristics for patients with primary ovarian malignancies...
September 28, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28941312/the-dual-role-of-treg-in-cancer
#15
REVIEW
Magdalena Frydrychowicz, Maciej Boruczkowski, Agata Kolecka-Bednarczyk, Grzegorz Dworacki
Regulatory T cells (Tregs) represent a small subpopulation of CD4(+) cells. Tregs are characterized by the expression of transcription factor Forkhead box protein 3 (FoxP3), also known as scurfin. Tregs are modulators of adaptive immune responses and play an important role in maintaining tolerance to self-antigens, providing the suppression associated with tumor microenvironment as well. These immunomodulatory properties are the main reason for the development of numerous therapeutic strategies, designed to inhibit the activity of cancer cells...
September 23, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28941291/dysregulation-of-circulating-tfr-tfh-ratio-in-primary-biliary-cholangitis
#16
Jiajia Zheng, Tiancheng Wang, Li Zhang, Liyan Cui
Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are critical for the development and maintenance of germinal center (GC) and humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of either Tfh cells or Tfr cells contributes to the pathogenesis of autoimmune diseases. We aim to investigate the roles of circulating Tfh cells and circulating Tfr cells in the pathogenesis of primary biliary cholangitis (PBC). 34 PBC patients and 27 health individuals were enrolled in this study...
September 23, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28930377/epigenetics-the-future-direction-in-systemic-sclerosis
#17
REVIEW
M Walczyk, A Paradowska-Gorycka, M Olesinska
Systemic sclerosis (SSc) is an immune-mediated connective tissue disease of which the aetiology is still unclear. Previous genetic studies including candidate-gene studies and genomewide association studies have identified a number of genetic variations that confer risk to SSc. However, these variants, such as single nucleotide polymorphisms, cannot completely explain the SSc susceptibility and the diversity in the clinical symptoms of SSc patients. The contribution of epigenetic mechanisms as a link between genetics and environmental triggers represents promising field in understanding the pathogenesis of SSc...
August 21, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28930374/the-prognostic-significance-of-soluble-programmed-death-ligand-1-expression-in-cancers-a-systematic-review-and-meta-analysis
#18
REVIEW
Y Ding, C Sun, J Li, L Hu, M Li, J Liu, L Pu, S Xiong
The differential expression of soluble programmed death ligand 1 (sPD-L1) has been found in some cancers; however, the correlation between sPD-L1 expression and prognosis value in tumour is still unclear. Here, we conducted a meta-analysis and systematic review to assess the prognostic value of sPD-L1 in patients with cancer. Eligible studies were searched for in the databases including PubMed, Web of Science, ScienceDirect and Wiley Online Library database. The pooled hazard ratios (HRs) with a 95% confidence interval (95%CI) were calculated to assess the prognostic significance of sPD-L1 in human cancer...
November 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28891256/composition-and-variation-analysis-of-the-t-cell-receptor-%C3%AE-chain-complementarity-determining-region-3-repertoire-in-neonatal-sepsis
#19
J Sun, B Sun, Y Gao, F He, L Yang, M Wang, W Zhou
T cell receptor (TCR) diversity is clearly related to protection from infection. However, the characteristics of TCR diversity in neonates are not clear. In this study, we investigated the TCR diversity of neonates with sepsis. Twenty neonates with severe sepsis and eight matched neonates without infection were enrolled in the study. For the neonates with sepsis, EDTA-anticoagulated blood was collected on day 1 after the diagnosis of sepsis and on day 7 of treatment. For the neonates without infection, blood was collected one time...
November 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28889482/tlr-induced-smpd3-defects-enhance-inflammatory-response-of-b-cell-and-macrophage-in-the-pathogenesis-of-sle
#20
F Liu, X Li, H Yue, J Ji, M You, L Ding, H Fan, Y Hou
B lymphocyte and macrophages may contribute to SLE pathogenesis through cytokine production after TLR stimulation. Emerging evidences suggested that defects of sphingolipid metabolism were responsible for SLE pathogenesis. However, it is not clear whether these defects exist in B cells and macrophages under SLE condition and whether TLR signalling pathway was related to the dysfunction of sphingolipid metabolism in SLE. Here, we demonstrated that the enzymes involved in the sphingolipid metabolism expressed abnormally in B cells from SLE patients and lupus-prone mice...
November 2017: Scandinavian Journal of Immunology
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