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Scandinavian Journal of Immunology

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https://www.readbyqxmd.com/read/30375024/redox-imbalance-and-il-17-responses-in-memory-cd4-t-cells-from-patients-with-psoriasis
#1
Behnaz Esmaeili, Parvin Mansouri, Amir Hossein Doustimotlagh, Maryam Izad
All stages of the inflammatory process involved in T cell mediated chronic skin disorders like psoriasis are affected by Redox imbalance. On the other hand, Th17 cells have a critical role in the pathogenesis of psoriasis. In this study, we evaluated redox status in memory CD4+ T cells and plasma of patients with psoriasis and its correlation with IL-17 response. To this end, memory T cells were isolated from 10 patients with psoriasis and 10 controls. Intracellular Glutathione (GSH), reactive oxygen species (ROS) and superoxide as well as IL-17 were measured using flow cytometry...
October 29, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30375016/lprg-and-pe_pgrs33-mycobacterium-tuberculosis-virulence-factors-induce-differential-mitochondrial-dynamics-in-macrophages
#2
Bruno A Aguilar-López, Francisco Correa, María Maximina B Moreno-Altamirano, Clara Espitia, Rocío Hernández-Longoria, Jacqueline Oliva-Ramírez, Juan Padierna-Olivos, F Javier Sánchez-García
The interaction of a pathogen with its host cell takes place at different levels, including the bioenergetics adaptation of both the pathogen and the host cell in the course of an infection. In this regard, Mycobacterium tuberculosis infection of macrophages induces mitochondrial membrane potential (Δψm) changes and cytochrome c release, depending on the bacteria strain's virulence, and the mitochondrial dynamics is modified by pathogens, such as Listeria monocytogenes. Here, we investigated whether two M...
October 29, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30372549/the-dosr-antigen-rv1737c-from-mycobacterium-tuberculosis-confers-inflammation-regulation-in-tuberculosis-infection
#3
Xiaoling Gao, Cong Wu, Xiaoxia Wang, Hui Xu, Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Wenhua He, Yongxiang Wang, Benzhong Zhang
There is an urgent need to identify the potential risk factors for activating latent Mycobacterium tuberculosis infection. In this study, we evaluated the immune function of Rv1737c, which is a latency-associated antigen of dormancy survival regulator (DosR) of M. tuberculosis in a mouse model. Our data showed that mice pretreated with recombinant Rv1737c (rRv1737c) exhibited higher levels of antigen-specific antibodies (IgG, IgM and IgA) than sham-treated mice. Following Bacilli Calmette-Guerin (BCG) challenge, rRv1737c adjuvanted with cholera toxin subunit B (CTB) induced diffuse lung inflammation and fibrosis compared to the control mice...
October 29, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30341772/the-roles-of-socs3-and-stat3-in-bacterial-infection-and-inflammatory-diseases
#4
REVIEW
Yu Gao, Honglei Zhao, Peng Wang, Jun Wang, Lili Zou
The suppressor of cytokine signaling-3 (SOCS3) is well-known as a feedback inhibitor of the Janus kinases-signal transducer and activator of transcription-3 (JAK/STAT3) signaling pathway, which mediates the signal transduction of many cytokines, growth factors and hormones during many cellular processes. The critical role of SOCS3 is manifested by its binding to both the JAK kinase and the cytokine receptor, which can result in the inhibition of STAT3 phosphorylation. STAT3 triggers variety of genes expression in response to cytokine (IL-6 family, IL-10) and growth factor stimulation, and thus plays a critical role in many cellular biological processes involved in anti/pro-inflammatory responses, cell growth and cell death...
October 19, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30311672/the-real-danger-lies-in-the-failure-to-confront-fundamentals
#5
REVIEW
Melvin Cohn
Can we formulate a framework that would provide an agreed upon basis for discussions of immune behavior? An attempt to do this is, in the end, the main goal of this essay. If you tell a physicist that you have invented a perpetual motion machine, he wouldn't spend any time trying to reveal the flaw. Rather, he would shrug you off because in his framework, such a machine is an impossibility. However, immunologists lacking an agreed upon, preferably default, framework spend their time chasing into dead end alleys or take refuge in descriptive empiricism...
October 12, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30307657/serum-cytokine-measurements-and-biological-therapy-of-psoriasis-prospects-for-personalized-treatment
#6
Silje Michelsen Solberg, Lene Frøyen Sandvik, Marianne Eidsheim, Roland Jonsson, Yenan Troi Bryceson, Silke Appel
Psoriasis is an immune mediated disease where the IL-23/Th17 axis as well as TNF comprise main targets of biological therapy. Immune profiling has so far not been embraced as a clinical tool. We aimed to investigate relationships between individual serum cytokine levels in 40 psoriasis patients before and after receiving biological therapy and Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI). Serum concentration of 25 cytokines was determined by Luminex technology. Mean PASI and DLQI decreased by 71% and 65%, respectively...
October 11, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30403025/ccr2-upregulated-on-peripheral-t-cells-in-osteoarthritis-but-not-in-bone-marrow
#7
Kurt Arkestål, Michael Mints, Anders Enocson, Ludvig Linton, Per Marits, Hans Glise, John Andersson, Ola Winqvist
Osteoarthritis (OA) is a condition affecting millions of patients around the world, causing pain and disability and often resulting in joint replacement surgery. The aetiology of OA has long been attributed to mechanical wear mainly due to the increased prevalence of OA in load bearing joints among older patients. However, recent studies reveal a complex molecular disease causality in which inflammation, nutritional deficit and angiogenesis lead to the destruction of the joint structure. The aim of this study was to examine chemokine receptor expression in peripheral blood and bone marrow in OA patients...
October 8, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30403024/maternal-immunization-downregulates-offspring-tcd4-regulatory-cells-tregs-thymic-maturation-without-implications-for-allergy-inhibition
#8
Marília Garcia de Oliveira, Aline Aparecida de Lima Lira, Fábio da Ressureição Sgnotto, Amanda Harumi Sabô Inoue, Giovanna Rossi Beltrame, Débora da Silva, Ricardo Palamar Menghini, Alberto José da Silva Duarte, Jefferson Russo Victor
The regulation of offspring allergy development mediated by maternal immunization was evidenced by several groups, and this mechanism seems to involve the induction of regulatory T cells (Tregs) on offspring. Here, we aimed to evaluate whether the effect of maternal immunization on offspring Tregs occurs as a result of peripheral or central modulation. Briefly, C57BL/6 female mice were immunized with OVA in Alum or Alum alone and boosted with OVA in saline or saline only after 10 and 20 days. Non-immunized offspring serum, thymus and spleen were evaluated at 3 or 20 days old, and some groups of pups were submitted to neonatal OVA-immunization protocol for the subsequent evaluation of antibody production and allergic response...
October 8, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30303258/elevated-levels-of-interleukin-33-are-associated-with-allergic-and-eosinophilic-asthma
#9
Edita Gasiuniene, Ieva Janulaityte, Zivile Zemeckiene, Diana Barkauskiene, Brigita Sitkauskiene
IL-33 is a recently discovered cytokine which plays an important role in asthma pathogenesis. AIM: to evaluate serum IL-33 in patients with asthma and healthy controls, and to evaluate the association of IL-33 with different asthma phenotypes. METHODS: Patients with asthma (n=115) and healthy subjects (n=85) were included in the study. Subjects with asthma were divided into groups according to their phenotype: allergic/non-allergic, eosinophilic/non-eosinophilic, obese/non-obese and severity according to GINA (mild, moderate, severe)...
October 8, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30295952/associations-of-tumor-necrosis-factor-%C3%AE-polymorphisms-with-the-risk-of-tuberculosis-a-meta-analysis
#10
Yi Qiu, Sizhe Cao, Chaolun Gou, Ying Yue, Shen Jiang, Tingting Ma, Xin Xue
Recently, the roles of tumor necrosis factor-α (TNF-α) polymorphisms in tuberculosis (TB) were intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between TNF-α polymorphisms and the risk of TB. Eligible studies were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess correlations between TNF-α polymorphisms and TB. A total of 31 studies were included for analyses...
September 26, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30277586/recovery-from-acute-lung-injury-can-be-regulated-via-modulation-of-regulatory-t-cells-and-th17-cells
#11
Linlin Wang, Xiaocen Wang, Lin Tong, Jian Wang, Maosen Dou, Shimeng Ji, Jing Bi, Cuicui Chen, Dong Yang, Hong He, Chunxue Bai, Jian Zhou, Yuanlin Song
Acute lung injury (ALI) is a severe inflammatory disease, for which no specific treatment exists. The decreased ratio of regulatory T cells (CD4+ CD25+ FoxP3 Tregs) and Th17 cells is implicated in ALI and inflammation. We here investigated whether maintaining the balance of CD4+ CD25+ Foxp3+ Tregs and Th17 cells can alleviate lung injury. For CD4+ CD25+ FoxP3 Treg depletion, 200 μg of an anti-CD25 antibody was administered intraperitoneally per mouse on days -3 and -1 before lipopolysaccharide (LPS) instillation...
November 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30260514/infliximab-ameliorates-tumor-necrosis-factor-alpha-induced-insulin-resistance-by-attenuating-ptp1b-activation-in-3t3l1-adipocytes-in-vitro
#12
Lucia A Méndez-García, Fernanda Trejo-Millán, Camilo P Martínez-Reyes, Aarón N Manjarrez-Reyna, Marcela Esquivel-Velázquez, Guillermo Melendez-Mier, Sergio Islas-Andrade, Araceli Rojas-Bernabé, Julia Kzhyshkowska, Galileo Escobedo
Insulin resistance is the inability to respond to insulin and is considered a key pathophysiological factor in the development of type 2 diabetes. Tumor necrosis factor-alpha (TNF-alpha) can directly contribute to insulin resistance by disrupting the insulin signalling pathway via protein-tyrosine phosphatase 1B (PTP1B) activation, especially in adipocytes. Infliximab (Remicade® ) is a TNF-alpha-neutralizing antibody that has not been fully studied in insulin resistance. We investigated the effect of infliximab on TNF-alpha-induced insulin resistance in 3T3L1 adipocytes in vitro, and examined the possible molecular mechanisms involved...
November 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30247785/ifn-%C3%AE-4-inhibits-hiv-infection-of-macrophages-through-signalling-of-ifn-%C3%AE-r1-il-10r2-receptor-complex
#13
Qi-Jian Su, Xu Wang, Run-Hong Zhou, Le Guo, Hang Liu, Jie-Liang Li, Wen-Zhe Ho
The recently discovered IFN-λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-λ4 can inhibit HIV infection. Here, we show that IFN-λ4 could suppress HIV infection of macrophages. This IFN-λ4-mediated HIV inhibition was compromised by the antibodies against IFN-λ receptor complex, IFN-λR1/IL-10R2. IFN-λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon-stimulated genes. These findings indicated that IFN-λ4 can inhibit HIV via JAK/STAT signalling pathway...
November 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30226638/impaired-neutrophil-extracellular-traps-and-inflammatory-responses-in-the-peritoneal-fluid-of-patients-with-liver-cirrhosis
#14
Juan Manuel Agraz-Cibrián, Vidal Delgado-Rizo, Jorge Enrique Segura-Ortega, Héctor Alfredo Maldonado-Gómez, José Francisco Zambrano-Zaragoza, Ma de Jesus Durán-Avelar, Norberto Vibanco-Perez, Mary Fafutis-Morris
Liver cirrhosis (LC) is an inflammatory process associated with impaired functions in adaptive and innate immune responses at both systemic and local levels, also referred as Cirrhosis-Associated Immune Dysfunction. In this study, we evaluated the functionality of neutrophils from ascitic fluid (AF) of patients with hepatic cirrhosis by testing their ability to generate neutrophil extracellular traps (NETs) in vitro. To further determine the activation state of neutrophils, expression of the activation markers CD66b, CD69, and CD80 on these cells was analysed by flow cytometry...
November 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30176060/regulation-of-fatty-acid-synthesis-in-immune-cells
#15
REVIEW
Xuchen Qian, Zhitao Yang, Enqiang Mao, Erzhen Chen
Metabolic reprogramming plays a critical role in the important cellular metabolic alterations that occur during the activation of immune cells to enable them to adapt to the extracellular environment. Here, we review recent studies on how substrate availability and metabolites mediate the signalling pathways that regulate fatty acid synthesis (FAS) in different immune cells and how FAS determines cellular fate and function. The major regulators sterol regulatory element-binding proteins and liver X receptors, the key enzyme ATP citrate lyase and the PI3K-Akt-mTOR signalling axis play important roles in de novo FAS during a variety of biological events, including cellular proliferation and differentiation and the development of organelles and intracellular membrane components in immune cells...
November 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30270447/decreased-regulatory-function-of-cd4-cd25-cd45ra-t-cells-and-impaired-il-2-signalling-pathway-in-patients-with-type-2-diabetes-mellitus
#16
Vida Sheikh, Alireza Zamani, Elham Mahabadi-Ashtiyani, Hanieh Tarokhian, Shiva Borzouei, Mahdi Alahgholi-Hajibehzad
In this study, the frequency and function of CD4+ CD25+ CD45RA+ regulatory T cells (Treg) and intracellular IL-2 signalling molecules in patients with type 2 diabetes mellitus (T2DM) were investigated. Tregs and responder T cells (Tresp, CD4+ CD25- T cells) were sorted and suppression assays were performed using flow cytometry. Phosphorylation of signal transducer and activator of transcription-5 (pSTAT5) were assessed using flow cytometry. Gene expression of FOXP3 was performed with the SYBR green Real Time PCR method...
October 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30270439/patients-with-out-of-hospital-cardiac-arrest-show-decreased-human-leucocyte-antigen-dr-expression-on-monocytes-and-b-and-t-lymphocytes-after-return-of-spontaneous-circulation
#17
Zhijiang Qi, Le An, Bo Liu, Qiang Zhang, Wenpeng Yin, Han Yu, Chunsheng Li
Immune disorders are an important feature of patients with out-of-hospital cardiac arrest (OHCA) after return of spontaneous circulation (ROSC). However, the precise immune alterations in patients with OHCA that occur immediately after ROSC are unclear. In this study, we investigated human leucocyte antigen-DR (HLA-DR) expression on circulatory monocytes and B and T lymphocytes. Sixty-eight consecutive patients with OHCA with ROSC >12 hours were enrolled. Clinical data and 28-day survival were recorded...
October 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30247778/concurrent-cross-reactivity-of-microbiota-derived-epitopes-to-both-self-and-pathogens-may-underlie-the-hygiene-hypothesis
#18
David Usharauli, Tirumalai Kamala
The current iteration of the "Hygiene hypothesis" proposes precipitous decline in exposure to conserved microbial products and metabolites in individuals in developed countries undermines innate self-nonself "training" of immune system leading to allergy and autoimmunity. However, lack of innate "training" alone fails to account for the antigen-driven nature of these immunopathologies. Here, we advance an alternative, antigen-specific interpretive framework, SPIRAL (Specific ImmunoRegulatory Algorithm) that predicts "loss" of commensal microbiota-derived epitopes cross-reactive to both self and pathogens, rather than conserved microbial moieties or metabolites, underlies the "Hygiene hypothesis...
October 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30176062/acacetin-regulated-the-reciprocal-differentiation-of-th17-cells-and-treg-cells-and-mitigated-the-symptoms-of-collagen-induced-arthritis-in-mice
#19
Lin Liu, Junxia Yang, Beibei Zu, Jingya Wang, Kang Sheng, Lin Zhao, Weiwei Xu
BACKGROUND AND AIM: The immune-regulative effect of acacetin on the development of autoimmune arthritis remains unexplored. This study aims to investigate the potential effect of acacetin on the treatment of collagen-induced arthritis (CIA) in mice and clarify its underlying mechanism. METHODS AND RESULTS: In a type II collagen (CII)-induced autoimmune arthritis model, acacetin significantly repressed the incidence of CIA, prevented the pathological alteration, and reduced CII-specific IgG and IgG1 levels...
October 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30175850/development-of-tuberculosis-vaccines-in-clinical-trials-current-status
#20
REVIEW
Patricia Méndez-Samperio
Tuberculosis (TB) is an important infectious disease worldwide. Currently, Bacillus Calmette-Guérin (BCG) remains the only TB vaccine licensed for human use. This TB vaccine is effective in protecting children against severe military TB but offers variable protective efficacy in adults. Therefore, new vaccines against TB are needed to overcome this serious disease. At present, around 14 TB vaccine candidates are in different phases of clinical trials. These TB vaccines in clinical evaluation can be classified into two groups including preventive pre- and post-exposure vaccines: subunit vaccines (attenuated viral vectors or adjuvanted fusion proteins), and whole-cell vaccines (genetically attenuated Mycobacterium tuberculosis (M...
October 2018: Scandinavian Journal of Immunology
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