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Scandinavian Journal of Immunology

Takashi Ishii, Yuichi Niikura, Keigo Kurata, Masashi Muroi, Ken-Ichi Tanamoto, Takahide Nagase, Masahiro Sakaguchi, Naomi Yamashita
House dust mites (HDMs) are a common source of allergens that trigger both allergen-specific and innate immune responses in humans. Here we examined the effect of allergen concentration and the involvement of Toll-like receptor 4 (TLR4) in the process of sensitization to house dust mite allergens in an HDM-extract-induced asthma mouse model. Intranasal administration of HDM extract induced an immunoglobulin E response and eosinophilic inflammation in a dose-dependent manner from 2.5 to 30 μg/dose. In TLR4-knockout mice, the infiltration of eosinophils and neutrophils into the lung was decreased compared with that in wild-type mice in the early phase of inflammation (total of three doses)...
January 16, 2018: Scandinavian Journal of Immunology
Melvin Cohn
Evolution found itself in a Catch-22 situation when selecting for the somatically derived paratopic repertoire of the humoral immune system. The B-cell BCR repertoire can only be somatically diversified from a substrate of paratopes that is encoded in the germline. In order for the cells expressing that substrate to also be a target of germline selection, their BCRs must, independently, be of selective value by being expressed in a functionally important way in each individual. A somatically derived repertoire scrambles this substrate so that its specificities are lost, making it unselectable in the germline...
January 3, 2018: Scandinavian Journal of Immunology
Cinzia Lo Conte, Chiara Allegrini, Andrea Matucci, Maurizio Bartolucci, Elisabetta Rosi, Gianna Camiciottoli, Marina Amendola, Massimo Pistolesi, Elena Bargagli
We read with interest the recent manuscript from Gupta et al. reporting innate and adaptive immunological alterations occurring in patients with yellow nail syndrome (YNS) (1). The authors observed that immunoglobulin administration, in the subset of YNS patients with immunoglobulin deficiency, may result not only in decreased frequency and severity of infections but also in an impressive effect on lymphoedema and pleural effusion recurrence. They described a single patient (1). This article is protected by copyright...
December 27, 2017: Scandinavian Journal of Immunology
Stian André Engen, Olav Schreurs, Fernanda Petersen, Inger Johanne Schytte Blix, Espen S Baekkevold, Karl Schenck
Streptococcus mitis colonizes all niches of the human oral cavity from early infancy and throughout life. Monocytes patrol blood vessels, lymphoid and non-lymphoid tissues, and migrate into infected tissue where they participate in the inflammatory cascade and immune regulation. Here, we studied the effect of S. mitis on monocytes. Transcriptome analysis of monocytes exposed to S. mitis (SmMo) revealed increased transcription of chemotactic factors (CCL2, CCL3, CCL20, CXCL1, CXCL2) and cytokines (IL1A, IL1B, IL6, IL23, IL36G, TNF), indicating that S...
December 1, 2017: Scandinavian Journal of Immunology
Ping Lu, Xiaoyun Ji, Jie Wan, Huaxi Xu
The metabolic syndrome (MS) is an independent risk factor for type 2 diabetic nephropathy, and accompanied by subclinical inflammation which involves immune-deriving factors. Emerging studies indicate that ILC2s can regulate adipose metabolism, but much less is known about the activity of ILC2s in metabolic imbalance in obesity and diabetes. The present study explored the effect of ILC2s-related molecules on the occurrence of metabolic syndrome in type 2 diabetic nephropathy. Thirty patients with type 2 diabetic nephropathy were included in the study, the mRNA expression of ILC2s associated molecules from peripheral blood mononuclear cell and the correlation of the ILC2s activity and the metabolic syndrome related indicators were analyzed...
December 1, 2017: Scandinavian Journal of Immunology
Krista Kuuliala, Anne K Penttilä, Kirsi-Maija Kaukonen, Harri Mustonen, Antti Kuuliala, Jani Oiva, Mari Hämäläinen, Eeva Moilanen, Ville Pettilä, Pauli Puolakkainen, Leena Kylänpää, Heikki Repo
Intracellular signaling in blood leukocytes shows multiple aberrations in acute pancreatitis (AP) complicated by organ dysfunction (OD). We studied whether the aberrations associate with severity of AP and occur in sepsis complicated by OD. Study comprises 14 sepsis patients (11 with shock), 18 AP patients (9 mild; 6 moderately severe; 3 severe), and 28 healthy volunteers. Within 48 hours after admission to hospital, phosphorylation of nuclear factor-ĸB (NF-ĸB), signal transducers and activators of transcription (STATs) 1,3, and extracellular signal-regulated kinases 1/2 was measured from stimulated or non-stimulated leukocytes using phosphospecific whole blood flow cytometry...
November 29, 2017: Scandinavian Journal of Immunology
T W Eichler, C Totland, M Haugen, C A Vedeler
We have previously identified cancer patients with the paraneoplastic antibody, anti-Yo and the less characterized antibody, anti-CCDC104 (coiled-coil domain containing protein 104, also referred to as CFAP36 or BARTL1) [1]. CCDC104 has been localized to both the nucleus and cytoplasm of neuroblastoma cells [1] and the protein may have a role in the formation of cellular cilia [2, 3]. Anti-Yo consists of antibodies against cerebellar degeneration related protein 2 (CDR2) and cerebellar degeneration related protein 2 like (CDR2L), respectively [4, 5]...
November 28, 2017: Scandinavian Journal of Immunology
Elaine Speziali de Faria, Juscilene da Silva Menezes, Andrezza Fernanda Santiago, Nelson Monteiro Vaz, Ana Maria Caetano de Faria
Oral tolerance is defined as a state of systemic hyporesponsiveness to an antigen that has been previously administered by the oral route. Many factors affect oral tolerance induction, some of them related to antigen, some related to the animal. The age of the animal is one of the most important factors that affect oral tolerance as aging brings many alterations in immune responses. Herein, we demonstrated that both the oral tolerance as well as pattern of immune reactivity triggered in early life was kept up to 15 months regarding the magnitude of antibody production, cell proliferation and cytokine profile when compared to immune responses induced in old mice...
November 28, 2017: Scandinavian Journal of Immunology
Chenlu Liu, Yu Xie, Bo Sun, Fei Geng, Fangfang Zhang, Qianqian Guo, Hui Wu, Bin Yu, Jiaxin Wu, Xianghui Yu, Wei Kong, Haihong Zhang
DNA vaccination is a promising cancer treatment due to its safety, but poor immunogenicity limits its application. However, immunoadjuvants, heterogeneous prime-boost strategies and combination with conventional treatments can be used to improve the anti-tumor immune effects. A CpG motif and interleukin 2 (IL-2) cytokine are often used as adjuvants. In this study, a DNA vaccine containing a CpG motif was constructed to evaluate its adjuvant effect. The results show that the cytotoxicity of the DNA vaccine was increased 5-fold, and survival life time was prolonged 2-fold by the CpG motif adjuvant...
November 28, 2017: Scandinavian Journal of Immunology
Steffen Ullitz Thorsen, Christian B Pipper, Jesper Johannesen, Henrik Bindesbøl Mortensen, Flemming Pociot, Jannet Svensson
BACKGROUND: B cells have recently entered the stage as an important accessory player in type 1 diabetes (T1D) etiopathogenesis. Experimental studies suggest regulatory functions of vitamin D on B cells. However, only a few human studies, with considerable methodological limitations, have been conducted within this field. OBJECTIVE: Our objective was to investigate if higher 25-hydroxyvitamin D (25(OH)D) concentrations were inversely associated with β-cell autoantigens glutamic acid decarboxylase (isoform 65) (GADA) and insulinoma associated antigen-2A (IA-2A)...
November 10, 2017: Scandinavian Journal of Immunology
Qiang Xie, Ming Ni, Shi-Cun Wang
Recently, we read with great interest the article by Issa, et al., who showed that baseline galectin-3 was significantly increased in anti-CCP positive rheumatoid arthritis (RA) patients when compared to anti-CCP negative patients and healthy controls [1]. Moreover, experssion of galectin-3 correlated with baseline smoking, anti-CCP, and with MRI erosion score after 1 year of follow-up. These data indicated that galectin-3 is closely linked to autoimmunity in RA, and may play an important role in the pathogenesis of RA...
November 9, 2017: Scandinavian Journal of Immunology
Li Zhang, Junli Yan, Baohui Yang, Gaofu Zhang, Mo Wang, Shifang Dong, Wei Liu, Haiping Yang, Qiu Li
OBJECTIVE: This study (1) analyzed the percentage of γδ T cells, γδ T cell subsets, Th17 cells, and regulatory T cells (Treg cells), and (2) determined the role of IL-23 in primary nephrotic syndrome (PNS) patients with active disease and in remission. MATERIALS AND METHODS: Eighty-four PNS patients and 51 healthy age-matched controls were included in this study. The percentage of γδ T cells, γδ T cell subsets, Th17 cells, and Treg cells in peripheral blood mononuclear cells (PBMCs) were analyzed by fluorescence-activated cell sorting...
November 9, 2017: Scandinavian Journal of Immunology
Peter E Newburger
I read with interest the report by Kulkarni, Gupta, and Madkaikar,[1] cited above. It was good to see that modern technology of flow cytometry could be applied to the phenotypic prenatal diagnosis of CGD. However, I disagree with their assessment that flow cytometry for dihydrorhodamine fluorescence is preferable to histochemical detection of nitroblue tetrazolium (NBT) reduction. This article is protected by copyright. All rights reserved.
November 9, 2017: Scandinavian Journal of Immunology
Renate Krüger, Stephan Borte, Katharina von Weizsäcker, Volker Wahn, Cornelia Feiterna-Sperling
Neonates with severe T- and/or B-lymphopenia can be identified within the first week of life using T-cell-receptor-excision circles (TREC) and kappa-deleting-recombination-excision circles (KREC) screening of dried blood spots (DBS). Newborns exposed to rituximab (RTX; anti-CD20-antibody) due to maternal therapy during pregnancy may be identified as immunodeficient with B-cell lymphopenia because of drug induced transient depletion of B cells. We present a child with intrauterine exposure to RTX up to 30 weeks of gestation...
November 6, 2017: Scandinavian Journal of Immunology
Robby Engelmann, Andra Biemelt, Anja Johl, Daniela Kuthning, Brigitte Müller-Hilke
Attenuated T cell receptor (TCR) signaling contributes to the susceptibility for autoimmunity as shown via mutants of PTPN22 and Zap70 genes. We here set out to investigate the effect of an attenuated TCR signal on the composition of the thymic epithelial cell (TEC) compartment. To that extent, we combined flow cytometry and histology and compared the TEC subpopulations of Zap70 wild type with SKG mutant mice. We found an increased cortical TEC compartment in SKG thymi at the expense of reduced numbers of mature medullary TECs and a 4...
November 3, 2017: Scandinavian Journal of Immunology
Maria Bankvall, Mats Jontell, Agnes Wold, Sofia Östman
Defining the immune cells within the naso-oropharyngeal-associated lymphoid tissues would promote the development of efficient oral and nasal delivered immunotherapies. The aim was to compare murine antigen-presenting cells (APCs) and T-cell subsets in the nose-associated lymphoid tissues (NALT), cervical lymph nodes (CLN), mesenteric lymph nodes (MLN) and peripheral lymph nodes (PLN) using flow cytometry and in vitro proliferation assays. Overall, the NALT contained a higher proportion of APCs and a lower proportion of T cells compared to the CLN, MLN, and PLN...
October 27, 2017: Scandinavian Journal of Immunology
Richard Davies, Daniel Hammenfors, Brith Bergum, Kjerstin Jakobsen, Magne Solheim, Petra Vogelsang, Johan G Brun, Yenan Bryceson, Roland Jonsson, Silke Appel
An accurate dissection of peripheral blood enumeration is lacking in primary Sjögren's syndrome. The purpose of this study was to quantify different leukocyte populations in peripheral blood of patients with pSS. Numbers of specific leukocyte subsets were determined in 86 pSS patients and 74 healthy donors quantifying 21 distinct subtypes by flow cytometry. Subgroups of pSS patients were stratified based on presence of extraglandular manifestations (EGM) and SSA/SSB autoantibodies. Overall, pSS patients manifested decreased lymphocyte subpopulations compared to healthy donors...
October 26, 2017: Scandinavian Journal of Immunology
Manasi Kulkarni, Maya Gupta, Manisha Madkaikar
Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency disorder affecting the microbicidal function of the phagocytes. It is characterized by susceptibility to recurrent infections leading to significant morbidity and mortality. Antibacterial and antifungal prophylaxis though has significantly reduced the rate and severity of the infections; the breakthrough infections still remain a challenge. Currently allogenic hematopoietic stem cell transplantation is the only curative option which is very expensive and unavailable for many due to lack of suitable donor...
October 24, 2017: Scandinavian Journal of Immunology
Anna Fleischhackerová-Slimáková, Jana Korcová, Slavomír Bystrický
A glycoconjugate (dLPS-CBSA) from hydrazine-detoxified lipopolysaccharide of Vibrio cholerae O139 and BSA was used for immunization of Balb/c mice. The immunogenicity (concentration of induced IgG antibodies) of the conjugate was determined by enzyme-linked immunosorbent assay. The highest level of lipopolysaccharide-specific IgGs were found in sera collected two weeks after the third immunization. Both IgM and IgG antibodies present in the anti V. cholerae O139-specific sera showed long-lasting vibriocidal activity...
October 24, 2017: Scandinavian Journal of Immunology
R Jonsson, H-G Ljunggren
No abstract text is available yet for this article.
January 2018: Scandinavian Journal of Immunology
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