Read by QxMD icon Read

Scandinavian Journal of Immunology

Reza Yazdani, Gholamreza Azizi, Hassan Abolhassani, Asghar Aghamohammadi
Selective immunoglobulin A deficiency (SIgAD) is the most common primary antibody deficiency. Although more patients with SIgAD are asymptomatic, selected patients suffer from different clinical complications such as pulmonary infections, allergies, autoimmune diseases, gastrointestinal disorders and malignancy. Pathogenesis of SIgAD is still unknown, however, a defective terminal differentiation of B-cells and defect in switching to IgA-producing plasma cells are presumed to be responsible. Furthermore, some cytogenic defects and monogenic mutations are associated with SIgAD...
October 20, 2016: Scandinavian Journal of Immunology
Monika Lindemann, Marina Zaslavskaya, Melanie Fiedler, Benjamin Wilde, Falko M Heinemann, Andreas Heinold, Peter A Horn, Oliver Witzke
Approximately 70% of kidney transplant recipients are non-responders to conventional hepatitis B virus (HBV) vaccines. We examined whether Fendrix(™) , an HBV vaccine containing 3-O-desacyl-4'-monophosphoryl lipid A (MPL) as adjuvant, could induce HBV immunity in these patients and compared their vaccination efficacy with healthy controls tested previously by the same assays. We selected 35 kidney transplant recipients who had been vaccinated at least thrice against HBV but had never displayed anti-HBs antibodies...
October 20, 2016: Scandinavian Journal of Immunology
Chengliang Zhu, Guiqing Peng, Wei Yi, Hui Song, Fang Liu, Xinghui Liu
Influenza A virus (IAV) infection induces a strong immune response and regulates the expression of many host proteins. The collagen triple helix repeat containing 1 (CTHRC1) protein is a secreted protein that exhibits increased expression during the viral infection process. However, the regulatory function of IAV on CTHRC1 expression is obscure. In this study, we investigated the effect of IAV on CTHRC1 expression and its regulatory mechanism. A total of 106 serum specimens from healthy people and 80 serum specimens from patients infected with IAV were collected...
October 8, 2016: Scandinavian Journal of Immunology
Laurence S Harbige, Eva Pinto, Judith Allgrove, Linda V Thomas
Daily ingestion of a probiotic drink containing Lactobacillus casei Shirota (LcS; 1.3 x 10(10) live cells) by healthy adults for (i) 4-weeks LcS, (ii) 6-weeks discontinuation of LcS, and (iii) a final 4-weeks of LcS, was investigated. There was a significant increase in expression of the T-cell activation marker CD3(+) CD69(+) in ex vivo unstimulated blood cells at weeks 10 and 14 and a significant increase in the NK cell marker CD3(+) CD16/56(+) in ex vivo unstimulated blood cells at weeks 4, 10 and 14. Expression of the NK cell activation marker CD16/56(+) CD69(+) in ex vivo unstimulated blood cells was 62% higher at week 10 and 74% higher at week 14...
October 8, 2016: Scandinavian Journal of Immunology
Dorota Dąbrowska, Ewa Jabłońska, Marzena Garley, Wioletta Ratajczak-Wrona, Agnieszka Iwaniuk
The formation and release of neutrophil extracellular traps (NETs) discovered in 2004 by Volker Brinkmann and Arturo Zychlinsky cast a new light on the role of neutrophils in the non-specific immune response of the body. This discovery has resulted in the rapid development of neutrophil studies in different bacterial and autoimmune diseases as well as neoplasms. Research is also being performed on the role of different signalling pathways engaged in the induction of NETosis a unique form of a programmed cell death leading to the creation of NETs...
September 26, 2016: Scandinavian Journal of Immunology
Giovanni Delogu, Valentina Vanini, Gilda Cuzzi, Teresa Chiacchio, Flavio De Maio, Basem Battah, Carmela Pinnetti, Alessandro Sampaolesi, Andrea Antinori, Delia Goletti
RATIONALE: Heparin-binding haemagglutinin (HBHA) has been proposed as an immunological biomarker for discriminating active tuberculosis (TB) from latent TB infection (LTBI) and to identify those at higher risk of progressing to active disease. Few data are available in immune compromised patients, which are those with increased risk of TB reactivation. OBJECTIVE: To evaluate the immune response to HBHA in HIV-infected subjects with LTBI (HIV-LTBI) or active TB (HIV-TB) in comparison with the immune response to additional Mycobacterium tuberculosis (Mtb) or HIV and CMV antigens...
September 16, 2016: Scandinavian Journal of Immunology
Nara Vasconcelos Cavalcanti, Leuridan Cavalcante Torres, Marina Cadena da Matta, Carolina Duarte Lindoso, Luana Nobre de Abreu Carvalho, Maria do Carmo Menezes Bezerra Duarte, Jailson Barros Correia
Chemokines are chemotactic cytokines that are mainly involved in the migratory patterns of immune cells. Few studies have evaluated levels of chemokines in children with acute bacterial infections. The aim of the present study was to evaluate serum levels of chemokines MCP-1, RANTES, MIG and IP-10 in children with sepsis, community-acquired pneumonia (CAP) and skin abscess. Serum levels of MCP-1, RANTES, MIG and IP-10 were measured in 37 children with sepsis, 27 children with CAP, 25 children with skin abscess and 20 controls with no signs of infection...
September 16, 2016: Scandinavian Journal of Immunology
Funda Orhan, Maria Bhat, Kristian Sandberg, Sara Ståhl, Fredrik Piehl, Camilla Svensson, Sophie Erhardt, Lilly Schwieler
Tryptophan degradation along the kynurenine pathway is of central importance for the immune function. Toll-like receptors (TLRs), representing the first line of immune defense against pathogens, are expressed in various cell types. The most abundant expression is found on monocytes, macrophages and dendritic cells. The aim of the present study is to investigate if stimulation with different TLR ligands induces the kynurenine pathway in human peripheral monocytes. Cell supernatants were analyzed using a liquid chromatography/mass spectrometry to measure kynurenine, kynurenic acid (KYNA), quinolinic acid (QUIN) and tryptophan...
September 8, 2016: Scandinavian Journal of Immunology
Maria E Stålhammar, Richard Sindelar, Lena Douhan Håkansson
We have previously observed that neutrophils from neonates exhibit different migratory responses to intermediate and end-target chemoattractants compared to adults. The aim of the present study was to investigate the effect of the chemoattractants IL-8 (intermediate) and formyl-methionine-leucyl-phenylalanine (fMLP; end-target) on cell surface receptor expression involved in adhesion, migration and granule release of neutrophils from term newborn infants and adults. Heparinized cord blood from 16 healthy term infants delivered by caesarean section and peripheral blood from 17 healthy adults were incubated with 1 μM IL-8 or 0...
September 8, 2016: Scandinavian Journal of Immunology
Stig Palm Therkelsen, Geir Hetland, Torstein Lyberg, Idar Lygren, Egil Johnson
Ingestion of the Agaricus blazei Murill-based mushroom extract AndoSan(™) has been shown in randomized placebo-controlled studies to improve symptoms in Crohn's disease (CD) and ulcerative colitis (UC) and also fatigue and quality of life in the latter patients. The aim was to examine whether this clinical impact of AndoSan(™) intake could be explained by influence on foremost pro-inflammatory cytokines in the patients. Fifty patients with symptomatic UC and CD were randomized and blinded for oral daily intake of AndoSan(™) or placebo...
September 2, 2016: Scandinavian Journal of Immunology
Sabine Huenecke, Esther Fryns, Boris Wittekindt, Horst Buxmann, Christoph Königs, Andrea Quaiser, Doris Fischer, Melanie Bremm, Thomas Klingebiel, Ulrike Koehl, Rolf Schloesser, Konrad Bochennek
Preterm newborns show an increased susceptibility to infections, conceivably related to their immature immune system. To gain further knowledge about the immune development in early preterm infants, we aimed to establish references for lymphocyte subsets and compare the maturation process during hospitalization to healthy term-born children and adolescents. For this purpose peripheral blood samples (n=153) were collected from 40 preterm infants; gestational age (GA) 26 to 30 week between 2(nd) and 6(th) day of life and were monitored in intervals of every 2 or rather 4 weeks until the end of hospitalization...
August 22, 2016: Scandinavian Journal of Immunology
Zhaoliang Su, Ping Ni, Chenglin Zhou, Jia Wang
Myeloid-derived suppressor cell (MDSC) is an important heterogeneous cell population that regulates innate and adaptive immune. The immunosuppressive potentiality is widely known. However, more and more data indicated that the heterogeneous cell population had immunostimulatory activities rather than immunosuppression in some microenvironments. Chronic inflammatory conditions contribute to accumulate of MDSCs. These pathologically activated cells played critical roles in cancer and inflammatory diseases. In this review, we mainly discuss the immunoregulation potentiality of MDSCs in cancer and inflammatory diseases...
August 19, 2016: Scandinavian Journal of Immunology
A L C Figueiredo, A L C Domingues, W G Melo, T Tashiro, V M B de Lorena, S M L Montenegro, C N L Morais
The pathology of schistosomiasis is associated with the formation of granulomas and this process is associated with liver fibrosis. Studies indicate that Th1 cytokines reduce fibrosis in schistosomiasis, while Th2 cytokines play a part in the progression of fibrosis, and IL-13 has a critical role in this process. The IL-13Rα2 receptor, known as a "receptor antagonist" binds with high affinity to IL-13, and studies have identified that this plays a part in reducing fibrosis and the size of granulomas. The objective of this study was to evaluate the function of IL-13Rα2 and cellular immune response in hepatic fibrosis...
August 10, 2016: Scandinavian Journal of Immunology
Tugba Soydas, Ozcan Karaman, Hulya Arkan, Guven Yenmis, M Muzaffer Ilhan, Kubra Tombulturk, Ertugrul Tasan, Gonul Kanigur Sultuybek
Morbid obesity(MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP).Toll-like reseptor is possible candidate for inflamatory responses which is mainly mediated by NFKB. The aim of this study was to investigate the relationship between NFKB1 and TLR-2 polymorphisms and the risk of MO in a Turkish population in the context of CRP serum levels which may contribute to susceptibility to the disease. We analyzed the distribution of NFKB1 -94ins/delATTG rs28362491 and TLR-2 Arg753Gly rs5743708 polymorphisms using PCR-RFLP method and CRP serum levels using ELISA method in 213 MO and 200 healthy controls...
August 10, 2016: Scandinavian Journal of Immunology
Jae Hyun Jung, Gwan Gyu Song, Jae-Hoon Kim, Sung Jae Choi
The aim of this study was to perform a meta-analysis of eligible studies and to derive a precise estimate of the association between interleukin 10 (IL10) polymorphisms and susceptibility to autoimmune thyroid disease (AITD). Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871), and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD. A total of 2,903 AITD patients and 3,060 controls in 10 eligible studies were included in the meta-analysis...
August 8, 2016: Scandinavian Journal of Immunology
Soheil Tavakolpour, Hamid Reza Mahmoudi, Maryam Daneshpazhooh, Ghazal Rahimzadeh
Alopecia areata (AA) remained a disease without any licensed treatment. Although it is not a life-threating disease, it significantly affects the quality of life of patients. Lack of effective treatment for this disease may be due to little knowledge about its exact cellular mechanism. Several studies have shown that interferon-gamma (IFN-γ) is increased in AA, which could induce major histocompatibility complex (MHC) I expression. This article is protected by copyright. All rights reserved.
August 8, 2016: Scandinavian Journal of Immunology
Ying-Yin Sun, Xiao-Feng Li, Xiao-Ming Meng, Cheng Huang, Lei Zhang, Jun Li
Macrophages hold a critical position in the pathogenesis of liver injury and repair, in which their infiltrations is regarded as a main feature for both acute and chronic liver diseases. It is noted that, based on the distinct phenotypes and origins, hepatic macrophages are capable of clearing pathogens, promoting/or inhibiting liver inflammation, while regulating liver fibrosis and fibrolysis through interplaying with hepatocytes and hepatic stellate cells (HSC) via releasing different types of pro- or anti-inflammatory cytokines and growth factors...
August 5, 2016: Scandinavian Journal of Immunology
J Brozova, I Karlova, J Novak
Mucosal-associated invariant T (MAIT) cells contain two main subpopulations, CD8(+) and double-negative (DN) cells. The first reports suggested that subpopulations of MAIT cells have similar phenotype and function. Recent works, however, demonstrate that the subpopulations have different ontogenesis and are differentially affected by xenobiotic treatment. In this work, we re-examined the possible differences between subpopulations of MAIT cells. We demonstrate that the main subpopulations of MAIT cells (CD8 and DN) are relatively uniform in terms of both phenotype and function...
October 2016: Scandinavian Journal of Immunology
E G de Souza, C C P Hara, D L G Fagundes, A A de Queiroz, G Morceli, I M P Calderon, E L França, A C Honorio-França
This study investigated the expression of the neonatal Fc receptor (FcRn) in maternal blood, cord blood and placental cells and determined IgG levels in maternal blood and cord blood from diabetic mothers. Peripheral blood, cord blood and placenta samples were collected from 26 mothers with normoglycaemia (non-diabetic, ND group) and 52 with hyperglycaemia (26 with mild gestational hyperglycaemia, MGH group, and 26 with type 2 diabetes mellitus, DM-2 group). Cells expressing CD19(+) and FcRn were identified by flow cytometry...
October 2016: Scandinavian Journal of Immunology
P Méndez-Samperio
Currently, more than 9.0 million people develop acute pulmonary tuberculosis (TB) each year and about 1.5 million people worldwide die from this infection. Thus, developing vaccines to prevent active TB disease remains a priority. This article discusses recent progress in the development of new vaccines against TB and focusses on the main requirements for development of improved vaccines against Mycobacterium tuberculosis (M. tb). Over the last two decades, significant progress has been made in TB vaccine development, and some TB vaccine candidates have currently completed a phase III clinical trial...
October 2016: Scandinavian Journal of Immunology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"