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Scandinavian Journal of Immunology

Michal Koucký, Karin Malíčková, Helena Kopřivová, Tereza Cindrová-Davies, Hana Hrbáčková, Andrej Černý, Patrik Šimják, Antonín Pařízek, Tomáš Zima
BACKROUND: Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labor. Mannose-bindig lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birth weight in a cohort of women with signs of threatened preterm birth. METHODS: A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 to 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study...
May 14, 2018: Scandinavian Journal of Immunology
Jiaolin Sun, Ting Liu, Ying Yan, Kaikai Huo, Wenna Zhang, Hanhan Liu, Zhihong Shi
BACKGROUNDS: CD4 + Th1-CXCR3 signaling pathway may play a key role in Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to explore Th1/Th2 cytokines ratio differences of patients in different stages of COPD and to confirm the hypothesis that elastin exposure might serve as an antigen to initiate the stimulation of CD4 + Th1-CXCR3 immune inflammation pathway. METHODS: Patients of COPD in different stages and normal individuals were enrolled...
May 12, 2018: Scandinavian Journal of Immunology
Halin Bareke, Julide Akbuga
Cancer immunotherapy is a strong candidate for the long awaited new edition to standard cancer therapies. For an effective immunotherapy, it is imperative to delineate the players of anti-tumor immune response. As an important innate immune system effector mechanism, complement is highly likely to play a substantial role in cancer immunity. Studies suggest that there may be two different 'states of complement' that show opposing effects on cancer cells; a complement profile that has anti-tumor effects with low expression of mCRPs, lytic MAC concentration and moderate C5a concentration, and a complement profile that has protumor effects with high expression of mCRPs, sublytic MAC, and high concentrations of C5a...
May 7, 2018: Scandinavian Journal of Immunology
Yunan Wei, Shun Chen, Mingshu Wang, Anchun Cheng
The tripartite motif-containing proteins (TRIMs) comprise a large family of proteins with over 70 members in humans. Recent studies have shown that TRIMs play unexpected roles in the antiviral immune responses to infections by HIV, MLV, EMCV, AIV and other viruses. There are two mechanisms used by TRIMs in the inhibition of virus infections: I, TRIMs target the produced viruses for ubiquitination, which induces proteasome-dependent degradation, or they interact with host proteins to inhibit viral infection in various periods of the viral life cycle...
April 29, 2018: Scandinavian Journal of Immunology
Aino R Koskinen, Zhu-Zhu Cheng, Matthew C Pickering, Kalevi Kairemo, Taru Meri, H Terence Cook, Seppo Meri, T Sakari Jokiranta
Factor H is an important regulator of complement activation in plasma and on cell surfaces in both humans and mice. If FH function is compromised, inappropriate complement activation on self-surfaces can have disastrous effects as seen in the kidney diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy. Since FH constructs have been proposed to be used in treatment for these diseases, we studied the distribution of exogenous FH fragments in mice. Full-length mFH, mFH1-5 and mFH18-20 fragments were radiolabeled and their distribution was examined in WT, FH-/- and FH-/- C3-/- mice in vivo...
April 29, 2018: Scandinavian Journal of Immunology
Edward J Steele, Robyn A Lindley
In our view Melvin Cohn1 has set out the logical guidelines towards a resolution of the very real enigma of the selectability of vertebrate germline Ig V repertoires under the current evolutionary paradigm …" A somatically derived repertoire scrambles this (germline VL + VH) substrate so that its specificities are lost, making it un-selectable in the germline. Consequently, evolution faced an incompatibility." It is argued here in Reply that a reverse transcriptase-based soma-to-germline process (S->G) targeting germline V segment arrays goes some considerable way to resolving fundamental contradictions on the origin, maintenance and then real-time adaptive diversification of these limited sets of V segments encoded within various V repertoire arrays...
April 29, 2018: Scandinavian Journal of Immunology
Yong Yuan, Qin-Song Liu, Jing Zhao, Hua-Ping Tang, Jie Sun
Conventional allergic rhinitis (AR) treatments have limitations due to the lack of safety and complete cure strategy. We evaluated the effects of Silent information regulator 1 (SIRT1), a multifunctional molecule involved in a variety of inflammatory pathways, on murine AR model. Ovalbumin (OVA)-induced murine model was constructed, and recombinant SIRT1 was administered into the nostril continuously. The expression of SIRT1 was measured at mRNA and protein levels, and the allergic symptoms were evaluated. Protein levels of OVA-specific IgE, leukotriene C4 (LTC4), eosinophil cation protein (ECP), Prostaglandin D2 (PGD2), as well as different inflammatory cytokine mediators in the serum and nasal lavage fluid (NLF) were assessed by ELISA...
April 27, 2018: Scandinavian Journal of Immunology
Bruna de Gois Macêdo, Rephany Fonseca Peixoto, Bruna Leal Lima Maciel, Juliana de Assis Silva Gomes, Fátima de Lourdes Assunção Araújo de Azevedo, Robson Cavalcanti Veras, Isac Almeida de Medeiros, Teresa Cristina Soares de Lima Grisi, Demétrius Antônio Machado de Araújo, Ian Porto Gurgel do Amaral, Tatjana Keesen de Souza Lima
Although the semi-invariant natural killer T cells (iNKT) are a small subpopulation of cells in the peripheral blood, they are presumed to play a role in early stages of infection against various pathogens, including protozoa. This work investigates the activation status and cytokine profile of iNKT cells during human Leishmania infantum and Leishmania braziliensis infection. We studied iNKT cells in symptomatic active visceral patients (AVL) (n=8), symptomatic active cutaneous patients (ACL) (n=13), negative endemic controls (NEC) (n=6) and non-endemic controls (NonEC) (n=6), with and without Total Leishmania antigen stimulus (TLA)...
April 27, 2018: Scandinavian Journal of Immunology
Lekh N Dahal, Adam Gadd, Alexander D Edwards, Mark S Cragg, Stephen A Beers
Toll like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer. For this reason, over the last two decades, TLR and their associated signalling pathways have been targeted therapeutically to enhance innate and adaptive immunity. Several TLR ligands, both endogenous and synthetic are at various phases of clinical testing, and new ligands are continually emerging. Agonists of TLR7 are known immune response modifiers, simultaneously stimulating several cell types, resulting in immune cell activation and cytokine and chemokine release...
April 18, 2018: Scandinavian Journal of Immunology
Juliana Imgenberg-Kreuz, Johanna K Sandling, Albin Björk, Jessica Nordlund, Marika Kvarnström, Maija-Leena Eloranta, Lars Rönnblom, Marie Wahren-Herlenius, Ann-Christine Syvänen, Gunnel Nordmark
B-cells play a key role in the pathogenesis of primary Sjögren's syndrome (pSS). The aim of this study was to analyze the transcriptome of CD19+ B-cells from patients with pSS and healthy controls to decipher the B-cell-specific contribution to pSS. RNA from purified CD19+ B-cells from 12 anti-SSA antibody positive untreated female patients with pSS and 20 healthy blood donors were subjected to whole transcriptome sequencing. A false discovery rate corrected significance threshold of α<0.05 was applied to define differential gene expression...
April 14, 2018: Scandinavian Journal of Immunology
Juthika Menon, Vernon H Hoeppner, Andrew Judd, Carl A Power, Peter A Bretscher
Most people infected by Mycobacterium tuberculosis, about 90%, contain the pathogen and are healthy. Most investigators have concluded that pathogen-specific Th1 cells contribute to protection. Pulmonary tuberculosis, the most prevalent form of disease, is associated with destructive granulomas, the formation of which also appears to involve Th1 cells. In what sense then do the two Th1 components of the response, in healthy infected individuals and patients, differ? An insight to this question might provide clues for attaining effective vaccination and better treatment...
April 1, 2018: Scandinavian Journal of Immunology
Marilú Domínguez-Pantoja, Gabriela López-Herrera, Héctor Romero-Ramírez, Leopoldo Santos-Argumedo, Adriana K Chávez-Rueda, Ángeles Hernández-Cueto, Mónica Flores-Muñoz, Juan C Rodríguez-Alba
CD38 is a transmembrane protein expressed in B lymphocytes, that is able to induce responses as proliferation, differentiation or apoptosis. Several reports propose that CD38 deficiency accelerates autoimmune processes in murine models of autoimmune diabetes, lymphoproliferation, and rheumatoid arthritis. Other reports have shown elevated CD38 expression in B and T cells from patients with autoimmunity; however, the role of CD38 is still unclear in the development of autoimmunity. Recently, it has been characterized as CD1dhi CD5+ regulatory B cell subpopulation able to produce IL-10, and the loss of this cells exacerbate the autoimmunity in murine models...
March 30, 2018: Scandinavian Journal of Immunology
Gholamreza Azizi, Fatemeh Kiaee, Ehsan Hedayat, Reza Yazdani, Elahe Dolatshahi, Tina Alinia, Laleh Sharifi, Hamed Mohammadi, Hoda Kavosi, Farhad Jadidi-Niaragh, Vahid Ziaee, Hassan Abolhassani, Asghar Aghamohammadi
INTRODUCTION: Common variable immunodeficiency (CVID) is the most prevalent symptomatic type of human primary immunodeficiency diseases (PID). Clinically, CVID is characterized by increased susceptibility to infections and a wide variety of autoimmune and rheumatologic disorders. METHODS: All CVID patients registered in Iranian PID Registry (IPIDR) were enrolled in this retrospective cohort study. We investigated the frequency of rheumatologic diseases and its association with immunological and clinical phenotypes in CVID patients...
March 24, 2018: Scandinavian Journal of Immunology
Chun Wu, Shaolin He, Jie Liu, Boyuan Wang, Jibin Lin, Yanping Duan, Xiaonan Gao, Dazhu Li
ILC populations elaborate a similar cytokine expression pattern with helper T cell subsets Th1, Th2 and Th17. Recent studies indicate that CD25+ILC2 could alleviate atherosclerosis by altering lipid metabolism, whereas the depletion of CD90-expressing ILCs had no influence on atherosclerosis. Thus, these findings raise the question on whether ILC1 cells react on atherosclerosis. Hence, our group attempted to explore the role of ILC1 cells in atherosclerosis. We found that ILC1 cells have a high Th1-like gene expression of T-bet and IFN-γ, which is distinct from ILC2, ILC3, or conventional NK (cNK) cells...
March 23, 2018: Scandinavian Journal of Immunology
Ana Hernández, Paula Arbildi, Cecilia Sóñora, Natalia Del Río, Juan Martin Marques
Tissue transglutaminase is a ubiquitous and multifunctional protein that contribute to several processes such as apoptosis/survival, efferocytosis, inflammation and tissue repairing under physiological and pathological conditions. Several activities can be associated with well established functional domains; in addition, four RNA alternative splice variants have been described, characterized by sequence divergences and residues deletion at the C-terminal domains Tissue transglutaminase is recognized as the central player in the physiopathology of celiac disease mainly through calcium dependent enzymatic activities...
March 15, 2018: Scandinavian Journal of Immunology
Ephraim Fuchs, Polly Matzinger
In a commentary on our 1996 publication[1], Al-Yassin suggests that we mischaracterized the results of the classical neonatal tolerance experiments of Billingham, Brent, and Medawar (BBM)[2] when we stated that "[BBM} found that rodents injected at birth with hemopoietic cells from a genetically different donor were later able to accept transplants from the same donor". Al-Yassin points out that "BBM could only reliably induce tolerance by giving fetal mice allogeneic cells" and "BBM concluded that neonatal mice were in a 'null' period, during which inoculation with MHC-incompatible cells had no effect, i...
March 14, 2018: Scandinavian Journal of Immunology
G Al-Yassin
I describe here what I believe is a misrepresentation of the classic observations of Billingham, Brent and Medawar on "actively acquired tolerance," by Ridge, Fuchs and Matzinger; I set the record straight by revisiting the original literature and discussing the implications of this misinterpretation.
February 24, 2018: Scandinavian Journal of Immunology
Zhiyun Wang, Zhining Liu, Ling Wang, Junling Wang, Liping Chen, Hua Xie, Huiyun Zhang, Shaoheng He
IL-18 is likely to contribute to asthma. However, little is known regarding the role of IL-18 binding protein (BP) and IL-18 receptor (R) in asthma. Because the action of IL-18 in the body is regulated by IL-18BP and mast cells and basophils are key cell types involved in asthma, we investigated the expression of IL-18, IL-18BP and IL-18R in basophils and mast cells using flow cytometry and a mouse asthma model. We found that among basophils, approximately 53% and 51% were IL-18+ , 85% and 81% were IL-18BP+ basophils, and 19...
May 2018: Scandinavian Journal of Immunology
P Karagianni, E Zampeli, H M Moutsopoulos
No abstract text is available yet for this article.
May 2018: Scandinavian Journal of Immunology
K Tatemoto, Y Nozaki, R Tsuda, S Kaneko, K Tomura, M Furuno, H Ogasawara, K Edamura, H Takagi, H Iwamura, M Noguchi, T Naito
Mast cells play a central role in inflammatory and allergic reactions by releasing inflammatory mediators through 2 main pathways, immunoglobulin E-dependent and E-independent activation. In the latter pathway, mast cells are activated by a diverse range of basic molecules (collectively known as basic secretagogues) through Mas-related G protein-coupled receptors (MRGPRs). In addition to the known basic secretagogues, here, we discovered several endogenous protein and enzyme fragments (such as chaperonin-10 fragment) that act as bioactive peptides and induce immunoglobulin E-independent mast cell activation via MRGPRX2 (previously known as MrgX2), leading to the degranulation of mast cells...
May 2018: Scandinavian Journal of Immunology
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