journal
MENU ▼
Read by QxMD icon Read
search

Scandinavian Journal of Immunology

journal
https://www.readbyqxmd.com/read/28727155/mucosal-associated-invariant-mait-cells-are-deficient-in-systemic-sclerosis
#1
Arsène Mekinian, Thibaut Mahevas, Mohamad Mohty, Vincent Jachiet, Sébastien Rivière, Olivier Fain, Béatrice Gaugler
OBJECTIVES: Systemic sclerosis (SSc) is an autoimmune disease, characterized by fibrosis of the skin and other organs, vascular impairment and deficient immune responses. Mucosal associated invariant T cells (MAIT) cells have been involved in various inflammatory and autoimmune diseases. The aim of this study was to determine the frequencies of MAIT cells in the blood of patients with systemic sclerosis (SSc), and to compare their distribution in the different types of SSc. PATIENTS AND METHODS: Blood samples from SSc patients and healthy controls were examined by flow cytometer to analyze the frequencies of MAIT and γδ T cells...
July 18, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28708284/cd20-specific-immunoligands-engaging-nkg2d-enhance-%C3%AE-%C3%AE-t-cell-mediated-lysis-of-lymphoma-cells
#2
Matthias Peipp, Daniela Wesch, Hans-Heinrich Oberg, Sebastian Lutz, Anja Muskulus, Jan G J van de Winkel, Paul W H I Parren, Renate Burger, Andreas Humpe, Dieter Kabelitz, Martin Gramatzki, Christian Kellner
Human γδ T cells are innate-like T cells which are able to kill a broad range of tumor cells and thus may have potential for cancer immunotherapy. The activating receptor natural killer group 2 member D (NKG2D) plays a key role in regulating immune responses driven by γδ T cells. Here, we explored whether recombinant immunoligands consisting of a CD20 single-chain fragment variable (scFv) linked to a NKG2D ligand, either MHC class I chain-related protein A (MICA) or UL16 binding protein 2 (ULBP2), could be employed to engage γδ T cells for tumor cell killing...
July 14, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28675263/specific-and-cross-reactive-plasmablast-response-in-humans-after-primary-and-secondary-immunization-with-vi-capsular-polysaccharide-typhoid-vaccine
#3
Sari H Pakkanen, Jussi M Kantele, Lars Rombo, Anu Kantele
Secondary immunization with polysaccharide vaccines may imply a risk of hyporesponsiveness. Despite the wide use of typhoid Vi capsular polysaccharide vaccine, its potential tendency to hyporesponsiveness has been inadequately addressed. While previous studies have explored serum antibody responses, we applied a more sensitive approach, a single-cell assay for circulating plasmablasts, to compare primary and secondary responses. Twelve subjects received primary and booster doses of the Vi vaccine (Typherix(®)) at 30-37-month intervals...
July 3, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28671723/giving-context-to-nonself-marker-theories-of-immune-responsiveness
#4
REVIEW
Melvin Cohn
In 2001, long ago by modern standards, Matzinger changed the emphasis of her Danger Theory from one that downplayed the Self-Nonself discrimination to one that concerned itself with the regulation of effector class. This gave her theory a measure of validity that the other Nonself-marker theorists have yet to confront. However precision and clarity are still lacking. This article is protected by copyright. All rights reserved.
June 30, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28671713/complement-c5a-induced-changes-in-neutrophil-morphology-during-inflammation
#5
Stephanie Denk, Ronald P Taylor, Rebecca Wiegner, Erika M Cook, Margaret A Lindorfer, Katharina Pfeiffer, Stephan Paschke, Tim Eiseler, Manfred Weiss, Eberhard Barth, John D Lambris, Miriam Kalbitz, Tobias Martin, Holger Barth, David A C Messerer, Florian Gebhard, Markus S Huber-Lang
The complement and neutrophil defense systems, as major components of innate immunity, are activated during inflammation and infection. For neutrophil migration to the inflamed region, we hypothesized that the complement activation product C5a induces significant changes in cellular morphology before chemotaxis. Exposure of human neutrophils to C5a, dose- and time-dependently resulted in a rapid C5a receptor-1 (C5aR1)-dependent shape-change, indicated by enhanced flow cytometric forward-scatter area values...
June 30, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28675455/lps-induced-ex-vivo-cytokine-production-is-not-augmented-in-patients-with-von-hippel-lindau-disease
#6
LETTER
Dorien Kiers, Henri Jlm Timmers, Jelle Gerretsen, Peter Pickkers, Matthijs Kox
Patients with Von Hippel-Lindau disease (VHLd) have a monoallelic germ line mutation in the Von Hippel-Lindau (VHL) gene. The Von Hippel-Lindau protein (pVHL) facilitates degradation of the transcription factor Hypoxia Inducible Factor(HIF)-1α[1]. When a second hit affects the only well-functioning VHL gene left, HIF-1α is no longer degraded and its transcriptional activity can contribute to the development of highly vascularized benign and malignant tumors in VHLd [1]. This article is protected by copyright...
June 22, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28675453/new-dancing-couple-pd-l1-and-microrna
#7
REVIEW
Anna Grenda, Paweł Krawczyk
Lung cancer (LC) is the most common cause of cancer death in the world. A great challenge in treating NSCLC is the discovery of advanced, molecular tools to diagnose the disease in early stages as well as the development of immunotherapy. MicroRNAs are regulatory molecules (~20 nt in length) with the ability to regulate the expression of genes. The recently described PD-1 and PD-L1 molecules have great importance for potential use in immunotherapy of many cancers. These molecules are associated with immune checkpoints and provide an opportunity for the treatment of advanced NSCLC patients with synthetic monoclonal antibodies...
June 22, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28605050/the-abl-1-kinase-is-dispensable-for-nk-cell-inhibitory-signaling-and-is-not-involved-in-murine-nk-cell-education
#8
S Ganesan, T L Thanh, N Kadri, B J Chambers, S Meinke, P Brodin, E Vivier, D M Wetzel, A J Koleske, P Höglund
Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signaling in human NK cells involves Abl-1 (c-Abl)-mediated phosphorylation of Crk, lowering NK cell function via disruption of a signaling complex including C3G and c-Cbl, suggesting that NK cell education might involve c-Abl. Mice deficient in c-Abl expression specifically in murine NK cells displayed normal inhibitory and activating receptor repertoires...
June 12, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28561325/assays-for-infliximab-drug-levels-and-antibodies-a-matter-of-scales-and-categories
#9
L Bader, S M Solberg, S H Kaada, N Bolstad, D J Warren, S Gavasso, C G Gjesdal, C A Vedeler
Immunogenicity is a frequent cause of secondary non-response to tumor necrosis factor (TNF) inhibitors. Drug level measurement and detection of anti-drug antibodies has been shown to be cost-effective and clinically relevant, and a large number of assays are available for these purposes. It is, however, difficult to compare assays and translate results into clinical meaningful information due to different methodological approaches and a lack of assay standardization. We have analyzed infliximab drug levels and anti-drug antibodies in 107 patient samples using enzyme-linked immunoassays (ELISA), immunofluorometric assays (IFMA), and reporter gene assays (RGA) for drug and for antibody...
May 31, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28561280/anti-fc%C3%AE-riib-cd32-antibodies-differentially-modulate-murine-fviii-specific-recall-response-in-vitro
#10
Nadine Vollack, Julia Friese, Sabine Bergmann, Mark S Cragg, Andreas Tiede, Sonja Werwitzke
Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signaling pathways within immune cells. Data from a hemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitory FcγR (CD32) suppresses the formation of antibody secreting cells (ASCs) in vitro. Mechanisms preventing the FVIII-specific recall response, however, remain unclear. Here, the potential role of CD32 inhibition was studied by differentially modulating receptor activity with selected anti-CD32 monoclonal antibodies (mAbs)...
May 31, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28547744/bacterial-fmlp-modulates-both-ros-and-chemotaxis
#11
LETTER
Ritesh Kumar Tiwari
I have recently read an article entitled," Bacterial N-formyl Peptides Reduce PMA- and E.coli-induced Neutrophil Respiratory Burst in Term Neonates and Adults" by Stålhammar et al. published in the Scandinavian Journal of Immunology[1]. The paper nicely showed that fMLP at higher doses (>1nM) reduces the amount of ROS generated thus it may alter the course of immunopathology or clearance of infection. I would like to make a contribution to the above findings. This article is protected by copyright. All rights reserved...
May 26, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28543378/renal-transplantation-in-patients-with-pre-existing-hypogammaglobulinemia
#12
K P Lund, H Bruunsgaard, H V Marquart, S S Sørensen
Hypogammaglobulinemia is well-characterized as a common phenomenon after kidney transplantation. However, no reports of pre-existing hypogammaglobulinemia from kidney transplantation seem to be available. We have reviewed three patients who developed hypogammaglobulinemia prior to kidney transplantation, and all three were treated successfully with immunoglobulin-replacement therapy before and after kidney transplantation. The kidney grafts were functioning at follow-up 1.5 to 8 years (mean: 3.6 years) after transplantation, and there were no diagnosed episodes of clinical rejections and no severe infection complications post-transplantation...
May 22, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28513991/immunoprotective-effect-of-chitosan-particles-on-hymenolepis-nana-infected-mice
#13
Mahmoud Abdel-Latif, Gamal El-Shahawi, Shawky M Aboelhadid, Heba Abdel-Tawab
Hymenolepis nana is the most commonly known intestinal cestode infecting mainly human. The present study aimed to investigate the potential effect of chitosan particles (CSP) to enhance the immune system against H. nana infection. Determination of worm burden, egg output, histopathological changes, oxidative stress markers (lipid peroxidation & reduced glutathione), goblet (GCs) and mucosal mast cells (MMCs) counts in intestinal ileum were performed. In addition, levels of intestinal mRNA expression of interleukin (IL)-4, IL-9, stem cell factor (SCF), type I & II interferons (IFN)-α/ γ, tumor necrosis factor (TNF)-α, mucin 2 (MUC2), and inducible nitric oxide synthase (iNOs) were investigated using real-time PCR...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28513984/spd-l1-expression-is-associated-with-immunosuppression-and-infectious-complications-in-patients-with-acute-pancreatitis
#14
Yang Chen, Meiling Li, Jialin Liu, Tingting Pan, Tianyun Zhou, Zhaojun Liu, Ruoming Tan, Xiaoli Wang, Lijun Tian, Erzhen Chen, Hongping Qu
Acute pancreatitis (AP) with infectious complications has high mortality because of early-stage immunosuppression. The programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is an important host immunosuppression mechanism. Soluble PD-L1 (sPD-L1) expression regulates coinhibitory signals in malignancies or autoimmune disorders; however, its effects in AP are unknown. Here, we evaluated whether serum sPD-L1 is involved in immune dysfunction and assessed its relationship with infectious complications in early AP...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28513867/the-role-of-circulating-t-follicular-helper-cells-and-regulatory-cells-in-non-small-cell-lung-cancer-patients
#15
Zhenxing Guo, Hailong Liang, Yaru Xu, Li Liu, Xiuhong Ren, Songsong Zhang, Shenhai Wei, Peng Xu
T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells are identified as the new subset of immune cells. This study aims to investigate the role of circulating Tfh cells (cTfh) and Tfr (cTfr) cells in the pathogenesis of non-small cell lung cancer (NSCLC). A total of 27 NSCLC patients and 19 age and sex matched healthy controls were enrolled. The percentage of cTfh and cTfr was detected by flow cytometric analysis. Compared to healthy controls, a significantly higher percentage of both cTfh and cTfr cells were observed in NSCLC patients (for cTfh, 18...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28513865/diagnosis-of-tuberculosis-in-hiv-co-infected-individuals-current-status-challenges-and-opportunities-for-the-future
#16
REVIEW
P Méndez-Samperio
Tuberculosis (TB) remains one of the most important causes of death amongst people co-infected with human immunodeficiency virus (HIV). The diagnosis of TB remains challenging in HIV co-infected individuals, due to a high frequency of smear-negative disease and high rates of extrapulmonary TB. Accurate, ease of use, and rapid diagnosis of active TB is critical to the World Health Organization (WHO) End TB Strategy by 2050. Traditional laboratory techniques do not provide rapid and accurate results to effectively manage HIV co-infected patients...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28500763/cross-talk-between-enzymes-matrix-metalloproteinsese-2-and-9-and-regulatory-t-cell-immunity-in-the-global-burden-of-atherosclerosis
#17
Andrica Lekic, Zdrinko Brekalo, Ante Kvesic, Miljenko Kovacevic, Zdenka Baricev-Novakovic, Ivana Sutic, Aleksandar Bulog, Ingrid Sutic, Valentino Pavisic, Ines Mrakovcic-Sutić
Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.) and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix-metalloproteinases (MMPs), whose concentration are increased in foam cell rich regions...
May 13, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28480606/chlamydia-pneumoniae-induces-interferon-gamma-responses-in-peripheral-blood-mononuclear-cells-in-children-with-allergic-asthma
#18
Tamar A Smith-Norowitz, Diana Weaver, Valeriy Chorny, Yitzchok M Norowitz, Danielle Lent, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Respiratory infections caused by Chlamydia pneumoniae have been associated with exacerbations of asthma. Cell mediated immunity (CMI) is critical for maintaining immunity. We compared Interferon (IFN)-γ responses in C. pneumoniae-infected peripheral blood mononuclear cells (PBMC) in pediatric patients +/- asthma. Presence of C. pneumoniae was tested from asthma patients (N=17) and non-asthmatic controls (N=16) (PCR). PBMC were infected for 1 hr +/- C. pneumoniae AR-39 (MOI = 0.1), and cultured for 48 hrs. IFN-γ levels were measured in supernatants (ELISA)...
May 8, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28474755/the-roles-of-tlr-gene-polymorphisms-in-atherosclerosis-a-systematic-review-and-meta-analysis-of-35-317-subjects
#19
REVIEW
Xiaochuan Xie, Xiaohan Shi, Meilin Liu
Recently, the roles of toll like receptor (TLR) gene polymorphisms in atherosclerotic diseases were extensively investigated, with conflicting results. Therefore, we performed the present study to better assess the relationship between TLR gene variants and atherosclerosis. Eligible studies were searched in PubMed, Medline, Embase, Web of Science, and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate associations between TLR gene polymorphisms and atherosclerosis. A total of 40 studies covering 19,657 cases and 15,660 controls were finally included in our systematic review and meta-analysis...
May 5, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28449222/tspan33-is-expressed-in-transitional-and-memory-b-cells-but-is-not-responsible-for-high-adam10-expression
#20
César Augusto Pérez-Martínez, José Luis Maravillas-Montero, Iván Meza-Herrera, Felipe Vences-Catalán, Albert Zlotnik, Leopoldo Santos-Argumedo
Tetraspanins are a family of transmembrane proteins that form membrane microdomains. They play important roles in migration, adhesion, and other cellular processes. TspanC8, a subfamily of tetraspanins, were found to associate and promote ADAM10 trafficking and cell surface localization. One of its members, Tspan33, is expressed in activated B cells. Using RT-PCR and flow cytometry, we analyzed the pattern of expression of Tspan33 in B cells from healthy donors. We found Tspan33 expression in early and late stages of B cell development...
April 27, 2017: Scandinavian Journal of Immunology
journal
journal
22806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"