journal
MENU ▼
Read by QxMD icon Read
search

Scandinavian Journal of Immunology

journal
https://www.readbyqxmd.com/read/28332200/immunoregulation-of-inflammatory-and-inhibitory-cytokines-by-vitamin-d3-in-patients-with-inflammatory-bowel-diseases-ibd
#1
REVIEW
Hussaini Mohammed Alhassan, Abbas Mirshafiey, Homayoun Vahedi, Gholamreza Hemmasi, Ateke Moussavi Nasl Khameneh, Karim Parastouei, Ali Akbar Saboor-Yaraghi
Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract, caused by an aberrant and exaggerated immunological response in the gut. Supplementation of Vitamin D3 in IBD patients exerts both direct and indirect regulatory roles on the naïve T-cells, thereby maintaining a balance between inflammatory and inhibitory cytokines. The direct actions of Vitamin D3 on naïve T-cells result in the proliferation of more regulatory T-cells and inhibitory cytokines such as IL-4, IL-10, and IL-5...
March 22, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28273403/pten-pi3k-akt-regulates-macrophage-polarization-in-emphysematous-mice
#2
JunJuan Lu, LiHua Xie, Chun Liu, Qiang Zhang, ShengHua Sun
Macrophages play an important role in the pathogenesis of COPD. Macrophage polarization toward the M2 phenotype has been observed in the lung tissues of COPD patients and cigarette smokers. The molecular basis of this process remains unclear, and it has not been completely illuminated in animal models of emphysema. In our study we combined cigarette smoke(CS) exposure with intraperitoneal injection of cigarette smoke extract (CSE) to build an emphysema model. We found by immunohistochemical staining and flow cytometry that the expression level of CD206 and the ratio of M2 to M1 macrophages was increased in emphysematous mice...
March 8, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28273384/computational-prediction-of-usutu-virus-e-protein-b-cell-and-t-cell-epitopes-for-potential-vaccine-development
#3
Navaneethan Palanisamy, Johan Lennerstrand
Usutu virus (family Flaviviridae), once confined to Africa, has emerged in Europe a decade ago. The virus has been spreading throughout Europe at a greater pace mostly affecting avian species. While most bird species remain asymptomatic carriers of this virus, few bird species are highly susceptible. Lately, Usutu virus (USUV) infections in humans were reported sporadically with severe neuroinvasive symptoms like meningoencephalitis. Since so much is unknown about this virus, which potentially may cause severe diseases in humans, there is a need for more studies of this virus...
March 8, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28273363/siglec-9-is-upregulated-in-rheumatoid-arthritis-and-suppresses-collagen-induced-arthritis-through-reciprocal-regulation-of-th17-treg-cell-differentiation
#4
Xiaoyuan Wang, Dan Liu, Yaxian Ning, Jiayu Liu, Xin Wang, Ran Tu, Haili Shen, Qun Chen, Yongmin Xiong
Sialic acid-binding Ig-like lectin-9 (Siglec-9) is a novel sialic acid-binding member of the immunoglobulin superfamily, and is broadly expressed on immune cells, which can inhibit both innate and adaptive immune responses through immunoreceptor tyrosine-based inhibitory motifs. However, the exact role of Siglec-9 in the pathogenesis of rheumatoid arthritis (RA) remains unknown. In this study, we determined soluble Siglec-9 (sSiglec-9) levels in the serum and synovial fluid of RA patients, and evaluated the relation between sSiglec-9 levels and clinical factors...
March 8, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28236642/immune-class-regulation-and-its-medical-significance-part-ii-of-a-report-of-a-workshop-on-foundational-concepts-of-immune-regulation
#5
REVIEW
Peter Bretscher, Alexandre Corthay, Colin C Anderson, Zlatko Dembic, Calliopi Havele, Zoltan A Nagy, Inger Øynebråten
We discussed different proposals for how the nature of the Th1/Th2 phenotype of an immune response is determined, and favored one, the Threshold Hypothesis, as plausible and so useful as the basis for further discussions. The activation of a target CD4 T cell can be facilitated by helper CD4 T cells when the CD4 T cells interact via an antigen-presenting cell (APC). The Threshold Hypothesis states that tentative and robust antigen-mediated CD4 T cell cooperation results in the target CD4 T cell respectively giving rise, upon activation, to Th1 and Th2 cells...
February 25, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28231624/targets-and-mechanisms-in-prevention-of-parkinson-s-disease-through-immunomodulatory-treatments
#6
REVIEW
Marianne von Euler Chelpin, Thomas Vorup-Jensen
Parkinson's Disease (PD) is the second most common neurodegenerative disease in the world, however, there is no cure for it. Current treatments only relieve some of the symptoms, without ceasing the disease, and lose efficacy with prolonged treatment. Considerable evidence shows that persistent inflammatory responses, involving T cell infiltration and glial cell activation, are common characteristics of human patients and play a crucial role in the degeneration of dopaminergic neurons. Therefore, it is important to develop therapeutic strategies that can impede or halt the disease through the modulation of the peripheral immune system by aiming at controlling the existing neuroinflammation...
February 23, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28218958/cd137-is-a-useful-marker-for-identifying-cd4-t-cell-responses-to-mycobacterium-tuberculosis
#7
Zhuo-Hong Yan, Xiao-Fang Zheng, Ling Yi, Jing Wang, Xiao-Jue Wang, Pan-Jian Wei, Hong-Yan Jia, Li-Jun Zhou, Yan-Lin Zhao, Hong-Tao Zhang
Upregulation of CD137 on recently activated CD8(+) T cells has been used to identify rare viral and tumor antigen-specific T cells from the peripheral blood. We aimed to evaluate the accuracy of CD137 for identifying Mycobacterium tuberculosis (Mtb)-reactive CD4(+) T cells in the peripheral blood of infected individuals by flow cytometry and to investigate the characteristics of these CD137(+) CD4(+) T cells. We initially enrolled 31 active tuberculosis (TB) patients, 31 individuals with latent TB infection (LTBI), and 25 healthy donors...
February 20, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28218951/igm-is-unable-to-enhance-antibody-responses-in-mice-lacking-c1q-or-c3
#8
LETTER
Anna Sörman, Annika Westin, Birgitta Heyman
Lack of complement factors C1q, C2, C3, or C4, but not of factor B in the alternative pathway or of mannane binding lectin (MBL) in the lectin pathway, leads to severe impairment of primary antibody responses (reviewed in. Because C1q is only used in classical pathway activation, these observations suggest that only this pathway is involved in antibody responses. An efficient classical pathway activator is IgM. Specific IgM, passively administered together with suboptimal doses of the antigen it recognizes, induces a stronger antibody response than does the antigen alone...
February 20, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28199746/a-commentary-on-a-workshop-to-reveal-the-foundational-concepts-of-immune-regulation-i-e-tolerance
#9
Melvin Cohn
A summary of the workshop with its laudatory goal "to reveal the foundational concepts in immunology" was recently published in SJI with an invitation to outsiders to comment. In the end a foundational concept is one upon which we can all agree. This requires debate and meaningful experimentation. The goal of this commentary is to provide some of that. Most of immunology is description of an observation (i.e., a fact). However what ties all the facts together as a discipline is theory or conceptualization that give a general context to observation and predicts the next step...
February 15, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28199745/bacterial-n-formyl-peptides-reduce-pma-and-e-coli-induced-neutrophil-respiratory-burst-in-term-neonates-and-adults
#10
Maria E Stålhammar, Lena Douhan Håkansson, Richard Sindelar
Neutrophil migration and respiratory burst is the prerequisite for efficient first line defense against invading microorganisms. However, migration and respiratory burst can be compromised in adults and especially in newborn infants, where sustained neutrophil accumulation, uncontrolled burst and reduced scavenging of ROS might cause inadvertent tissue damage due to uncontrolled inflammation. The aim of this study was to investigate the modulatory effect of the chemoattractants formyl-methionyl-leucyl-phenylalanine (fMLP) and IL-8 on respiratory burst in neutrophils from term newborn infants and adults...
February 15, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28199731/proteomic-profiling-analysis-reveals-a-link-between-experimental-autoimmune-uveitis-and-complement-activation-in-rats
#11
Dadong Guo, Bing Hu, Hongying Tang, Yuanyuan Sun, Bin Liu, Qingmei Tian, Hongsheng Bi
Uveitis is an autoimmune disease that usually damages the vision function, leading to poor visual quality in patients. As an autoimmune ocular inflammatory disease, the pathogenesis of uveitis is associated with abnormal expression of some proteins and aberrant regulation of multiple signaling pathways. Nevertheless, the detailed mechanism remains unclear. In this study, we induced an experimental autoimmune uveitis (EAU) model in rats. We determined the levels of C3a and membrane attack complex C5b-9 (soluble C5b-9, sC5b-9) in both plasma and aqueous humor, identified the differentially expressed proteins in plasma by liquid chromatography-tandem mass spectrometry, and employed bioinformatics algorithms to analyze differentially expressed proteins in EAU rat plasma...
February 15, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28199730/fentanyl-suppresses-the-survival-of-cd4-t-cells-isolated-from-human-umbilical-cord-blood-through-inhibition-of-ikks-mediated-nf-%C3%AE%C2%BAb-activation
#12
Kun Ma, Pengyu Ma, Huaihai Lu, Shuxiang Liu, Qinying Cao
The aim of this study was to investigate the effects and the underlying mechanisms of fentanyl anesthetic on T lymphocytes isolated from human umbilical cord bloodin vitro. The percentages of CD4(+) , CD8(+) , and regulatory T (Treg) cells in human umbilical cord blood mononuclear cells (UBMC) treated with fentanyl in vitrowere analyzed by flow cytometry. The levels of cytokines IFN-γ, IL-2, IL-4, and IL-17 secreted by activated CD4(+) T cells were measured by ELISA assays. Expressions of MAPK and NF-κB signaling pathway proteins were determined by Western blotting...
February 15, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28199728/altered-mir-155-expression-in-allergic-asthmatic-airways
#13
Carina Malmhäll, Kristina Johansson, Carla Winkler, Sahar Alawieh, Linda Ekerljung, Madeleine Rådinger
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at posttranscriptional level. We and others have previously identified miRNAs with pathological roles in animal models of asthma. To date, few studies have investigated miRNA expression in human asthmatics and miRNA expression in specific cellular subtypes in asthmatics is largely unexplored. Therefore, the aim of this study was to assess miR-146a and miR-155 expression in airways- and blood-derived samples, two miRNA candidates which have previously been described to play important roles in inflammatory processes...
February 15, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28168862/increased-systemic-cytokine-chemokine-expression-in-asthmatic-and-non-asthmatic-patients-with-bacterial-viral-or-mixed-lung-infection
#14
Maria J Giuffrida, Nereida Valero, Jesus Mosquera, Anyelo Duran, Francisco Arocha, Betulio Chacín, Luz Marina Espina, Jenifer Gotera, John Bermudez, Alibeth Mavarez, Melchor Alvarez-Mon
This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n=14) and non- asthmatic (n=29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analyzed as individuals with pneumonia or bronchitis...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28168837/immunity-in-filarial-infections-lessons-from-animal-models-and-human-studies
#15
REVIEW
Alexander Kwarteng, Samuel Terkper Ahuno
Our understanding of immunity to filarial infection is enigmatic and continues to be passionately debated. The mechanisms whereby filarial nematodes are killed in vivo and how these parasites avoid these mechanisms are poorly understood. Although vaccination studies in permissive animals took off seven decades ago, the exact mechanisms driving protective immunity is extensively being investigated. Currently, little is known regarding the collective functions or counter-regulatory mechanisms of the antibody isotypes in filarial infection with respect to protective immunity...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28168727/comparison-of-pro-inflammatory-cytokines-of-non-healing-and-healing-cutaneous-leishmaniasis
#16
Mohammad Moafi, Hossein Rezvan, Roya Sherkat, Roya Taleban, Ali Asilian, Sayyed Hamid Zarkesh-Esfahani, Mohammad Ali Nilforoushzadeh, Fariba Jaffary, Marjan Mansourian, Fatemeh Sokhanvari, Nazli Ansari
Cutaneous Leishmaniasis (CL) heals spontaneously within several weeks or months, but, in rare cases, CL active lesions last for many years. In the current study, we assessed cell-mediated immunity in non-healing CL through the measurement of three pro-inflammatory cytokines: Interferon-γ (IFN-γ), IL-17a, and CXCL-11. For this, 32 patients afflicted with healing or non-healing CL were recruited in this study. Peripheral blood mononuclear cells (PBMCs) of every patient were treated with three antigens: purified protein derivative (PPD), soluble Leishmania antigen (SLA), and Phytohaemagglutinin (PHA)...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28128856/experimental-arthritis-in-the-rat-induced-by-the-superantigen-staphylococcal-enterotoxin-a-sea
#17
Kristina Gerlach, Christian Tomuschat, Rainer Finke, Martin Sebastian Staege, Christine Brütting, Jörg Brandt, Berit Jordan, René Schwesig, Angela Rosemeier, Karl-Stefan Delank, Malte Erich Kornhuber, Alexander Emmer
The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. Human endogenous retroviruses (HERVs) and their superantigenic envelope protein (env) have been implicated in the pathogenesis of RA. In the present investigation the arthritogenic potential of the superantigen Staphylococcal enterotoxin A (SEA) has been investigated. In the present investigation, the bacterial superantigen Staphylococcal enterotoxin A (SEA) was injected into the right knee joint of 15 Lewis rats. Further 9 animals received saline...
January 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28128471/lack-of-fc-gamma-receptor-iiia-promotes-rather-than-suppresses-humoral-and-cellular-immune-responses-after-mucosal-or-parenteral-immunization-with-antigen-and-adjuvants
#18
Jia-Bin Sun, Jan Holmgren, Mark S Cragg, Zou Xiang
The Fcγ receptor IIIA (FcγRIIIA) has traditionally been known as a positive regulator of immune responses. Consistent with this, mice deficient in FcγRIIIA are protected from various inflammation-associated pathologies including several autoimmune diseases. In contrast to this accepted dogma, we show here that mice lacking FcγRIIIA developed increased rather than reduced both humoral and cellular immune responses to mucosal (sublingual) immunization with ovalbumin (OVA) given together with the strong mucosal adjuvant cholera toxin as well as to parenteral (subcutaneous) immunization with OVA in complete Freund's adjuvant...
January 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28128470/factors-influencing-serum-concentrations-of-igd-in-the-adult-population-an-observational-study-in-spain
#19
Iago Carballo, Noelia Rabuñal, Lucía Alvela, Luis-Fernando Pérez, Carmen Vidal, Manuela Alonso, Bernardo Sopeña, Francisco Gude, Arturo Gonzalez-Quintela
Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunologic factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commercial turbidimetric assay in 413 individuals (median age, 55 years; 45% males), randomly selected from the adult population of a Spanish municipality. Serum IgD concentrations displayed considerable variation in the population, ranging from undetectable (<6...
January 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28128469/regulatory-responses-during-chronic-hepatitis-b-virus-infection
#20
LETTER
Soheil Tavakolpour
I read with interest the recently published article by Wang et al.[1], which has demonstrated the key role of B and T lymphocyte attenuator (BTLA) molecule in impairment of intrahepatic hepatitis B virus (HBV)-specific T cells in 43 chronically HBV infected patients. Previously, we discussed the critical role of regulatory responses in induction of chronic HBV (CHB) infection [2]. We also hypothesized that inhibition of these responses could possibly result in seroclearance in CHB patients [3]. This could be done via inhibition of some co-inhibitory molecules, including programmed death-1 (PD-1), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), and cytotoxic T lymphocyte antigen-4 (CTLA-4)...
January 27, 2017: Scandinavian Journal of Immunology
journal
journal
22806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"