journal
MENU ▼
Read by QxMD icon Read
search

Drug Metabolism Reviews

journal
https://www.readbyqxmd.com/read/28617139/human-cytosolic-glutathione-s-transferases-quantitative-analysis-of-expression-comparative-analysis-of-structures-and-inhibition-strategies-of-isozymes-involved-in-drug-resistance
#1
Krishnamoorthy Mohana, Anant Achary
Glutathione-S-transferase (GST) inhibition is a strategy to overcome drug resistance. Several isoforms of human GSTs are present and they are expressed in almost all the organs. Specific expression levels of GSTs in various organs are collected from the human transcriptome data and analysis of the organ-specific expression of GST isoforms is carried out. The variations in the level of expressions of GST isoforms are statistically significant. The GST expression differs in diseased conditions as reported by many investigators and some of the isoforms of GSTs are disease markers or drug targets...
July 12, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28554218/implications-of-sulfotransferase-activity-in-interindividual-variability-in-drug-response-clinical-perspective-on-current-knowledge
#2
Natalia Marto, Judit Morello, Emilia C Monteiro, Sofia A Pereira
The interindividual variability in drug response is a major issue in clinical practice and in drug development. Sulfoconjugation is an important Phase II reaction catalyzed by cytosolic sulfotransferases (SULTs), playing a major role in homeostatic functions, xenobiotic detoxification, and carcinogen bioactivation. SULT display wide interindividual variability, explained only partially by genetic variation, suggesting that other non-genetic, epigenetic, and environmental influences could be major determinants of variability in SULT activity...
June 20, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28298144/raman-spectroscopy-using-plasmonic-and-carbon-based-nanoparticles-for-cancer-detection-diagnosis-and-treatment-guidance-part-2-treatment
#3
Emilie Darrigues, Vijayalakshmi Dantuluri, Zeid A Nima, Kieng Bao Vang-Dings, Robert J Griffin, Alexandru R Biris, Anindya Ghosh, Alexandru S Biris
Raman spectroscopy and surface-enhanced raman scattering (SERS) have the potential to improve the detection and monitoring of various diseases, particularly cancer, with or without the support of multifunctional active nanosystems. This review is focused on the recent advances that have made Raman a major tool for treatment guidance for surgical tumor resection or for analytical monitoring of various therapies, such as photodynamic therapy, photothermal therapy, and drug delivery. The potential of Raman spectroscopy and nanosytems to further improve cancer treatments is also discussed...
June 19, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28264609/raman-spectroscopy-using-plasmonic-and-carbon-based-nanoparticles-for-cancer-detection-diagnosis-and-treatment-guidance-part-1-diagnosis
#4
Emilie Darrigues, Zeid A Nima, Waqar Majeed, Kieng Bao Vang-Dings, Vijayalakshmi Dantuluri, Alexandru R Biris, Vladimir P Zharov, Robert J Griffin, Alexandru S Biris
Optical techniques, including Raman, photothermal and photoacoustic microscopy and spectroscopy, have been intensively explored for the sensitive and accurate detection of various diseases. Rapid advances in lasers, photodetectors, and nanotechnology have led to the development of Raman spectroscopy, particularly surface-enhanced Raman scattering (SERS), as a promising imaging modality that can help diagnose many diseases. This review focuses on the major recent advances in Raman spectroscopy and SERS-enhancing contrast nanoagents, as well as their potential to transition from a proof-of-concept approach to a cancer detection tool in vitro and in vivo...
June 15, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28571502/liver-toxicity-mechanisms-of-herbs-commonly-used-in-latin-america
#5
Sofía López-Gil, Natalia Nuño-Lámbarri, Norberto Chávez-Tapia, Misael Uribe, Varenka J Barbero-Becerra
Mexico owns approximately 4500 medicinal plants species, a great diversity that position it at the second place after China. According to the Mexican health department, 90% of common population consumes them to treat various diseases. Additionally, herbal remedies in Latin America are considered a common practice, but the frequency of use and the liver damage related to its consumption is still unknown. Despite the high prevalence and indiscriminate herbal consumption, the exact mechanism of hepatotoxicity and adverse effects is not fully clarified and is still questioned...
June 2, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28468514/biotransformation-and-bioactivation-reactions-2016-literature-highlights
#6
S Cyrus Khojasteh, Ivonne M C M Rietjens, Deepak Dalvie, Grover Miller
We are pleased to present a second annual issue highlighting a previous year's literature on biotransformation and bioactivation. Each contributor to this issue worked independently to review the articles published in 2016 and proposed three to four articles, which he or she believed would be of interest to the broader research community. In each synopsis, the contributing author summarized the procedures, analyses and conclusions as described in the original manuscripts. In the commentary sections, our authors offer feedback and highlight aspects of the work that may not be apparent from an initial reading of the article...
May 31, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28266877/glucuronidation-driving-factors-and-their-impact-on-glucuronide-disposition
#7
Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao, Ming Hu
Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high aqueous solubility. Glucuronidation involves the metabolism of parent compound by UDP-glucuronosyltransferases (UGTs) into hydrophilic and negatively charged glucuronides that cannot exit the cell without the aid of efflux transporters...
May 22, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28438049/ocular-non-p450-oxidative-reductive-hydrolytic-and-conjugative-drug-metabolizing-enzymes
#8
Upendra A Argikar, Jennifer L Dumouchel, Christine E Dunne, Andrea J Bushee
Metabolism in the eye for any species, laboratory animals or human, is gaining rapid interest as pharmaceutical scientists aim to treat a wide range of so-called incurable ocular diseases. Over a period of decades, reports of metabolic activity toward various drugs and biochemical markers have emerged in select ocular tissues of animals and humans. Ocular cytochrome P450 (P450) enzymes and transporters have been recently reviewed. However, there is a dearth of collated information on non-P450 drug metabolizing enzymes in eyes of various preclinical species and humans in health and disease...
May 17, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28393622/the-importance-of-drug-metabolites-synthesis-the-case-study-of-cardiotoxic-anticancer-drugs
#9
Ivanna Hrynchak, Emília Sousa, Madalena Pinto, Vera Marisa Costa
Anticancer drugs are presently guarantying more survivors as a result of more powerful drugs or combinations of drugs used in therapy. Thus, it has become more crucial to study and overcome the side effects of these therapies. Cardiotoxicity is one of the most relevant side effects on the long-term cancer survivors, because of its high social and economic impact. Drug metabolism can result in active metabolites or toxic metabolites that can lead to important side effects. The metabolites of anticancer drugs are possible culprits of cardiotoxicity; however, the cardiotoxicity of many of the metabolites in several drug classes was not yet suitably studied so far...
April 25, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28290706/the-metabolism-of-berberine-and-its-contribution-to-the-pharmacological-effects
#10
Kun Wang, Xinchi Feng, Liwei Chai, Shijie Cao, Feng Qiu
Berberine, a bioactive alkaloid isolated from several herbal substances, possesses multiple pharmacological effects, including antimicrobial, antidiabetic, anticancer activities. Meanwhile, berberine undergoes extensive metabolism after oral administration which results in its extremely low plasma exposure. Therefore, it is believed that the metabolites of berberine also contribute a lot to its pharmacological effects. Along these lines, this review covers the metabolism studies of berberine in terms of its metabolic pathways and metabolic organs based on the identified metabolites, and it also covers the pharmacological activities of its active metabolites...
April 3, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28303724/non-alcoholic-fatty-liver-disease-nafld-pathogenesis-classification-and-effect-on-drug-metabolizing-enzymes-and-transporters
#11
Enoch Cobbina, Fatemeh Akhlaghi
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption. Insulin resistance, the metabolic syndrome or type 2 diabetes and genetic variants of PNPLA3 or TM6SF2 seem to play a role in the pathogenesis of NAFLD. The pathological progression of NAFLD follows tentatively a "three-hit" process namely steatosis, lipotoxicity and inflammation. The presence of steatosis, oxidative stress and inflammatory mediators like TNF-α and IL-6 has been implicated in the alterations of nuclear factors such as CAR, PXR, PPAR-α in NAFLD...
March 17, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28074670/metabolism-of-psilocybin-and-psilocin-clinical-and-forensic-toxicological-relevance
#12
Ricardo Jorge Dinis-Oliveira
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological variability between individuals that can influence dose-response and toxicological profile has been reported. This review aims to discuss metabolism of psilocybin and psilocin, by presenting all major and minor psychoactive metabolites...
February 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28030966/systemic-drugs-that-influence-titanium-implant-osseointegration
#13
Dragos Apostu, Ondine Lucaciu, Gheorghe Dan Osvald Lucaciu, Bogdan Crisan, Liana Crisan, Mihaela Baciut, Florin Onisor, Grigore Baciut, Radu Septimiu Câmpian, Simion Bran
Titanium implants are widely used on an increasing number of patients in orthopedic and dental medicine. Despite the good survival rates of these implants, failures that lead to important socio-economic consequences still exist. Recently, research aimed at improving implant fixation, a process called osseointegration, has focused on a new, innovative field: systemic delivery of drugs. Following implant fixation, patients receive systemic drugs that could either impair or enhance osseointegration; these drugs include anabolic and anti-catabolic bone-acting agents in addition to new treatments...
February 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27957864/drug-metabolism-and-liver-disease-a-drug-gene-environment-interaction
#14
Nathalie K Zgheib, Robert A Branch
Despite the central role of the liver in drug metabolism, surprisingly there is lack of certainty in anticipating the extent of modification of the clearance of a given drug in a given patient. The intent of this review is to provide a conceptual framework in considering the impact of liver disease on drug disposition and reciprocally the impact of drug disposition on liver disease. It is proposed that improved understanding of the situation is gained by considering the issue as a special example of a drug-gene-environment interaction...
January 23, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27826992/the-val158met-polymorphism-in-comt-gene-and-cancer-risk-role-of-endogenous-and-exogenous-catechols
#15
Katrin Sak
Catechol-O-methyltransferase, COMT, is an important phase II enzyme catalyzing the transfer of a methyl-group from S-adenosylmethionine to a catechol-containing substrate molecule. A genetic variant Val158Met in the COMT gene leads to a several-fold decrease in the enzymatic activity giving rise to the accumulation of potentially carcinogenic endogenous catechol estrogens and their reactive intermediates and increasing thus the risk of tumorigenesis. However, numerous association studies between the COMT genotype and susceptibility to various malignancies have shown inconsistent and controversial findings indicating that additional gene-gene and gene-environment interactions might be crucial in modulating the physiological role of the COMT...
November 23, 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27819488/microsomal-cytochrome-p450-as-a-target-for-drug-discovery-and-repurposing
#16
Ahmed A El-Sherbeni, Ayman O S El-Kadi
Cytochrome P450 (P450) enzymes are ancient electron-transfer-chain system of remarkable biological importance. Microsomal P450 enzymes are the P450 attached to endoplasmic reticulum, which, in humans, are critical for body's defenses against xenobiotics by mediating their metabolism, and cell signaling by mediating arachidonic acid (AA) transformation to several potent bioactive molecules. Only recently, modulating P450-mediated AA metabolism has risen as a promising new drug target. This review presents the therapeutic potential of finding effective, selective and safe treatments targeting P450-mediated AA metabolism, and the several approaches that have been used to find these treatments; among which, our focus was on modulators of P450 activities...
November 22, 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27580162/comparative-metabolism-of-tramadol-and-tapentadol-a-toxicological-perspective
#17
Joana Barbosa, Juliana Faria, Odília Queirós, Roxana Moreira, Félix Carvalho, Ricardo Jorge Dinis-Oliveira
Tramadol and tapentadol are centrally acting, synthetic opioid analgesics used in the treatment of moderate to severe pain. Main metabolic patterns for these drugs in humans are well characterized. Tramadol is mainly metabolized by cytochrome P450 CYP2D6 to O-desmethyltramadol (M1), its main active metabolite. M1 and tapentadol undergo mainly glucuronidation reactions. On the other hand, the pharmacokinetics of tramadol and tapentadol are dependent on multiple factors, such as the route of administration, genetic variability in pharmacokinetic components and concurrent consumption of other drugs...
November 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27546072/pharmacogenetics-of-irinotecan-doxorubicin-and-docetaxel-transporters-in-asian-and-caucasian-cancer-patients-a-comparative-review
#18
Sylvia Chen, Natalia Sutiman, Clara Zhenxian Zhang, Yingnan Yu, Shirley Lam, Chiea Chuen Khor, Balram Chowbay
Drug efflux and influx transporters play critical roles in regulating the cellular drug disposition and modulating the pharmacokinetics and pharmacodynamics of anti-cancer agents, which may potentially alter treatment outcomes. The efficiency of drug transport is often dependent on the expression and activity of these membrane-bound proteins, factors which have been shown to be regulated by genes that are known to be highly polymorphic in different ethnic populations. The role of drug transporters becomes even more critical for anti-cancer agents due to the narrow therapeutic windows that separate treatment response and toxicities for these agents...
November 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27533622/non-cytochrome-p450-mediated-bioactivation-and-its-toxicological-relevance
#19
Jinping Gan, Shuguang Ma, Donglu Zhang
The bioactivation of drugs is often associated with toxicological outcomes; however, for most cases, the causal relationship between bioactivation and toxicity is not well established despite extensive research that attempts to elucidate the mechanisms leading to the formation of chemically reactive species, presumably the initial step towards adverse reactions. Due to rapid advancement in the research of cytochrome P450s (CYPs) and the prevalence of CYP involvement in the metabolic clearance of pharmaceuticals, CYP-mediated bioactivation is widely investigated and reviewed, while non-CYP-mediated bioactivation has not been emphasized...
November 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27461571/memorial-address-for-dr-hideyuki-yamada-distinguished-professor
#20
Yuji Ishii
No abstract text is available yet for this article.
November 2016: Drug Metabolism Reviews
journal
journal
22785
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"