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Scandinavian Journal of Rheumatology

S D Kay, A L Carlsen, A Voss, M Burton, Acp Diederichsen, M K Poulsen, Nhh Heegaard
OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a high risk of atherosclerosis and cardiovascular disease (CVD). MicroRNAs (miRNAs) are small non-coding RNAs that modulate protein translation, and dysregulation is seen in autoimmunity, atherosclerosis, and CVD. We investigate associations between circulating miRNAs and markers of atherosclerosis in SLE patients. METHOD: A group (n = 121) of well-characterized SLE patients were screened for atherosclerosis by cardiac computed tomography and carotid ultrasound...
July 9, 2018: Scandinavian Journal of Rheumatology
C H Brahe, M Østergaard, J S Johansen, N Defranoux, X Wang, R Bolce, E H Sasso, L M Ørnbjerg, K Hørslev-Petersen, K Stengaard-Pedersen, P Junker, T Ellingsen, P Ahlquist, H Lindegaard, A Linauskas, A Schlemmer, M Y Dam, I Hansen, T Lottenburger, C Ammitzbøll, A Jørgensen, S B Krintel, J Raun, M L Hetland
OBJECTIVES: Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive protein (DAS28-CRP) remission and radiographic progression in the double-blinded OPERA trial. METHOD: Treatment-naïve RA patients (N = 180) with moderate or high DAS28 were randomized to methotrexate (MTX) + adalimumab (n = 89) or MTX + placebo (n = 91) in combination with glucocorticoid injection into swollen joints...
July 9, 2018: Scandinavian Journal of Rheumatology
A Onishi, Y Tanaka, A Morinobu
No abstract text is available yet for this article.
July 5, 2018: Scandinavian Journal of Rheumatology
A Bilberg, T Bremell, J Bjersing, K Mannerkorpi
OBJECTIVES: The aim of the study was to determine the prevalence of widespread pain (WP) in women with early rheumatoid arthritis (RA) and to compare physical function, activity limitations, health-related quality of life, mental distress, and disease activity between women with WP and non-widespread pain (NWP). METHOD: This cross-sectional study included 102 women with early RA. Participants were provided with self-reported questionnaires quantifying activity limitations, physical activity, pain intensity, health-related quality of life, and fatigue...
July 5, 2018: Scandinavian Journal of Rheumatology
A Valls-Ontañón, I Méndez-Manjón, O L Haas-Junior, V Ruiz-Magaz, F Hernández-Alfaro
No abstract text is available yet for this article.
July 2, 2018: Scandinavian Journal of Rheumatology
M Marshall, G Peat, E Nicholls, H L Myers, M A Mamas, D A van der Windt
OBJECTIVE: To determine whether selected metabolic factors are associated with greater amounts of radiographic hand osteoarthritis (OA) incidence and progression. METHODS: The study identified 706 adults, aged 50-69 years, with hand pain and hand radiographs at baseline, from two population-based cohorts. Metabolic factors (body mass index, hypertension, dyslipidaemia, and diabetes) were ascertained at baseline by direct measurement and medical records. Analyses were undertaken following multiple imputation of missing data, and in complete cases (sensitivity analyses)...
June 28, 2018: Scandinavian Journal of Rheumatology
P Jakorinne, M Haanpää, J Arokoski
OBJECTIVES: Quantitative sensory testing (QST) is a method to assess somatosensory function in osteoarthritis (OA), but reliability data on the performance of different QST modalities on different joint structures are missing. The main aims of our study were to assess intertester and intratester reliability of tactile detection thresholds (TDTs), vibration detection thresholds (VDTs), and pressure pain thresholds (PPTs) on different knee joint structures. METHOD: In total, 32 subjects with knee OA and 32 volunteers with healthy knees participated...
June 25, 2018: Scandinavian Journal of Rheumatology
S M Hussain, Y Wang, J E Shaw, A E Wluka, S Graves, M Gambhir, F M Cicuttini
OBJECTIVE: To examine the association between obesity and knee and hip arthroplasty for osteoarthritis across a range of physical performance. METHOD: The body mass index and physical performance (on the 36-item Short Form Health Survey) of 9135 Australian Diabetes, Obesity and Lifestyle Study participants were measured in 1999-2000. The incidence of knee and hip arthroplasty during 2002-2011 was determined by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry...
June 22, 2018: Scandinavian Journal of Rheumatology
A Sejdic, N Graudal, B Baslund
OBJECTIVES: The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. The purpose of this study was to investigate the clinical and laboratory significance of high versus normal sACE levels in sarcoidosis...
June 22, 2018: Scandinavian Journal of Rheumatology
C-R Wang, M-F Liu, C-T Weng, W-C Lin, W-T Li, H-W Tsai
OBJECTIVE: Despite aggressive therapeutic regimens, diffuse alveolar haemorrhage (DAH) is still associated with a high mortality rate in systemic lupus erythematosus (SLE). This study was carried out in patients with SLE-associated DAH with a focus on their therapeutic modality. METHOD: A retrospective review was performed in 839 Han Chinese lupus patients hospitalized for their DAH manifestation from May 2006 to December 2016. RESULTS: There were 24 episodes in 17 cases (2...
June 19, 2018: Scandinavian Journal of Rheumatology
E D Batu, A Sarı, A Erden, H E Sönmez, B Armağan, U Kalyoncu, Ö Karadağ, Y Bilginer, A Akdoğan, S Kiraz, S Özen
OBJECTIVE: Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It is the most common primary systemic vasculitis of childhood and is much less common in adults. Our aim was to investigate the differences and similarities between adult and paediatric patients with IgAV/HSP. METHOD: We retrospectively evaluated the medical records of 35 adult and 159 paediatric (˂ 18 years old) patients with a clinical diagnosis of IgAV/HSP who were seen at the Departments of Rheumatology and Pediatric Rheumatology, Hacettepe University, Ankara, Turkey...
June 18, 2018: Scandinavian Journal of Rheumatology
I Yokoe, H Kobayashi, Y Kobayashi, J T Giles, K Yoneyama, N Kitamura, M Takei
OBJECTIVE: To prospectively investigate the effect of tocilizumab (TCZ) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), as a predictor of congestive heart failure (CHF) in patients with active rheumatoid arthritis (RA). METHOD: Seventy patients with RA (median age 59 years, 86% female) free of cardiovascular disease were treated with TCZ and followed for 24 weeks. The NT-proBNP levels were measured at baseline and week 24. Thirty healthy controls were included for comparison of normal NT-proBNP levels with those of RA patients...
May 28, 2018: Scandinavian Journal of Rheumatology
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
May 18, 2018: Scandinavian Journal of Rheumatology
F Sageloli, J L Quesada, B Fautrel, C Salliot, P Gaudin, A Baillet
OBJECTIVE: We conducted this study to determine whether alcohol consumption influences radiological progression in early rheumatoid arthritis (RA). METHOD: Patients fulfilling the European League Against Rheumatism/American College of Rheumatology 2010 criteria in the early arthritis cohort ESPOIR (Étude et Suivi des Polyarthrites Indifférenciées Récentes) were included in this study. Alcohol consumption was collected at baseline and at each visit. We classified alcohol consumption into three groups: abstinent (0 g/day), moderate (≤ 20 g/day for women, ≤ 30 g/day for men), and abuse (> 20 g/day for women, > 30 g/day for men)...
May 18, 2018: Scandinavian Journal of Rheumatology
J K Pedersen, R Holst, J Primdahl, A J Svendsen, K Hørslev-Petersen
OBJECTIVES: To investigate mortality and its predictors in a retrospectively defined population-based rheumatoid arthritis (RA) inception cohort Method: We included patients ascertained with incident RA from a region in the southern part of Denmark from 1995 to 2002. All patients fulfilled the 1987 American College of Rheumatology criteria for RA. The patients were followed from RA classification until death, emigration, or end of follow-up on 31 December 2013. We used personal record linkage with national public registers to obtain information on education, employment, cohabitation, comorbidity, and vital status...
May 9, 2018: Scandinavian Journal of Rheumatology
D N Maritsi, S Coffin, M Onoufriou, N Spyridis, M N Tsolia
No abstract text is available yet for this article.
May 9, 2018: Scandinavian Journal of Rheumatology
M Faurschou, N Obel, B Baslund
OBJECTIVE: To assess the long-term risk and outcome of infection-related hospitalization (IH) among patients with granulomatosis with polyangiitis (GPA). METHOD: We used administrative databases to establish a GPA cohort (n = 398), construct a comparison cohort of population controls (n = 3980), and collect clinical data. Cox regression analyses were used to determine hazard ratios (HRs) as a measure of relative risk. Follow-up began at date of GPA diagnosis and continued for up to 10 years...
May 9, 2018: Scandinavian Journal of Rheumatology
F Siljehult, L Ärlestig, C Eriksson, S Rantapää-Dahlqvist
OBJECTIVE: The efficacy of anti-tumour necrosis factor-α (anti-TNF-α) treatment with infliximab (IFX) may be reduced by the development of anti-drug antibodies (ADAs). This study evaluated drug concentration and the presence of ADAs, relative to response, in rheumatoid arthritis (RA) patients treated with IFX. METHOD: Ninety-four RA patients were consecutively included and assessed for disease activity at baseline, and after 14, and 30 or 52 weeks. Serum IFX concentration and ADAs were analysed using in-house enzyme-linked immunosorbent assays...
April 27, 2018: Scandinavian Journal of Rheumatology
V Torrente-Segarra, S A Bergstra, K Salomon-Escoto, Jap Da Silva, D J Veale, S Al-Emadi, Twj Huizinga
OBJECTIVE: To assess the association between smoking, anti-cyclic citrullinated peptide (anti-CCP) antibody status, and clinical efficacy of biological therapies in rheumatoid arthritis (RA) patients. METHOD: This retrospective clinical practice setting study included 1349 RA patients from the METEOR database (aged >18 years). We collected data on sociodemographics, smoking status (smoker, <10, 10-19, and >20 cigarettes/day; ex-smoker; non-smoker), baseline disease activity parameters and anti-CCP, previous disease-modifying anti-rheumatic drugs (DMARDs), biological therapy, combined therapy (steroids and DMARDs), and follow-up disease activity...
April 23, 2018: Scandinavian Journal of Rheumatology
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Scandinavian Journal of Rheumatology
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