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Scandinavian Journal of Rheumatology

M Kawauchi, T Watanabe, T Hattori, A Suzuki, A Ishizu, S Jodo
No abstract text is available yet for this article.
August 28, 2018: Scandinavian Journal of Rheumatology
C S Moura, E Rahme, W P Maksymowych, M Abrahamowicz, L Bessette, S Bernatsky
OBJECTIVE: To assess the risk of hospitalized infection among initiators of disease-modifying anti-rheumatic drugs (DMARDs) and/or anti-tumour necrosis factor (anti-TNF) agents in ankylosing spondylitis (AS). METHOD: We studied AS patients, new users of anti-TNF drugs and/or DMARDs between 1 January 2001 and 31 December 2011. Cohort entry was defined as the date of first prescription of any of these drugs. We used Cox regression with three time-varying drug exposures: current use of DMARDs without biologics, current use of anti-TNF agents alone or in combination with DMARDs (anti-TNF ± DMARDs), and current non-use...
August 16, 2018: Scandinavian Journal of Rheumatology
S Krabbe, B Glintborg, M Østergaard, M L Hetland
OBJECTIVE: To investigate whether axial spondyloarthritis (axSpA) patients with extremely poor patient-reported outcomes (PROs) at start of first tumour necrosis factor inhibitor (TNFi) treatment have poorer treatment response and shorter treatment retention than other patients. METHOD: This observational cohort study was based on the nationwide DANBIO registry. Patients with axSpA who started first TNFi during 2011-2016 were stratified according to baseline Bath Ankylosing Spondylitis Disease Activity Index (BASDAI ≥ 0...
August 13, 2018: Scandinavian Journal of Rheumatology
M L Hetland, M Østergaard, K Stengaard-Pedersen, P Junker, B Ejbjerg, S Jacobsen, T Ellingsen, H Lindegaard, J Pødenphant, A Vestergaard, A G Jurik, N S Krogh, K Hørslev-Petersen
OBJECTIVE: To investigate the clinical and radiographic status, and to identify baseline predictors of functional status and erosive progression at 11 years' follow-up of early rheumatoid arthritis (RA) patients. METHODS: Patients enrolled in the Danish investigator-initiated randomized controlled CIMESTRA trial, which investigated a 2 year treat-to-target intervention with methotrexate and intra-articular glucocorticoids with or without cyclosporine, were followed up...
August 13, 2018: Scandinavian Journal of Rheumatology
N J Mars, A M Kerola, M J Kauppi, M Pirinen, O Elonheimo, T Sokka-Isler
OBJECTIVES: Evidence of the economic burden and long-term outcomes of juvenile idiopathic arthritis (JIA) remains scarce. Our aim was to explore healthcare costs and long-term outcomes in adult patients with JIA. METHOD: We identified all adult patients (≥ 18 years) with JIA who visited Jyväskylä Central Hospital rheumatology unit between May 2007 and March 2016. We considered individual medians of time-dependent clinical variables. These data were linked to administrative data from the area from the fiscal year 2014, which include information on all public healthcare contacts...
August 2, 2018: Scandinavian Journal of Rheumatology
B Glintborg, U Lindström, K Aaltonen, E K Kristianslund, B Gudbjornsson, K Chatzidionysiou, J Askling, D Nordström, M L Hetland, D Di Giuseppe, L Dreyer, L E Kristensen, T S Jørgensen, K Eklund, G Grondal, S Ernestam, J Joensuu, Mrk Törmänen, H Skydsgaard, J Hagfors, T K Kvien, E Lie, K Fagerli, A J Geirsson, H Jonsson, S A Provan, N S Krogh, Lth Jacobsson
OBJECTIVES: Large-scale observational cohorts may be used to study the effectiveness and rare side effects of biological disease-modifying anti-rheumatic drugs (bDMARDs) in ankylosing spondylitis (AS), but may be hampered by differences in baseline characteristics and disease activity across countries. We aimed to explore the research infrastructure in the five Nordic countries regarding bDMARD treatment in AS. METHOD: This observational cohort study was based on data from biological registries in Denmark (DANBIO), Sweden (SRQ/ARTIS), Finland (ROB-FIN), Norway (NOR-DMARD), and Iceland (ICEBIO)...
August 2, 2018: Scandinavian Journal of Rheumatology
H Pettersson, C Boström, F Bringby, R Walle-Hansen, Lth Jacobsson, E Svenungsson, A Nordin, H Alexanderson
OBJECTIVE: Proximal muscle weakness is common in patients with systemic sclerosis (SSc). Dynamic muscle endurance, muscle strength in the lower extremities, and active range of motion (AROM) in the upper extremities are less studied. We investigated functional muscle endurance, strength, and AROM, and explored differences depending on skin and/or lung involvement in SSc patients. METHOD: The study divided 205 patients with limited/diffuse cutaneous systemic sclerosis (lcSSc/dcSSc) into no-mild and moderate-end-stage lung involvement, the latter based on the Medsger disease severity score...
August 2, 2018: Scandinavian Journal of Rheumatology
P E Carreira, L Carmona, B E Joven, E Loza, J L Andréu, G Riemekasten, S Vettori, A Balbir-Gurman, P Airò, U Walker, N Damjanov, M Matucci-Cerinic, L P Ananieva, S Rednic, L Czirják, O Distler, D Farge, R Hesselstrand, A Corrado, P Caramaschi, M Tikly, Y Allanore
OBJECTIVE: The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years' duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. METHOD: Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) was performed. Patients fulfilling preliminary American College of Rheumatology 1980 classification criteria for SSc, with < 3 years from the first non-Raynaud's SSc symptom at first entry, were selected...
July 24, 2018: Scandinavian Journal of Rheumatology
L E Bartels, A B Pedersen, N R Kristensen, P Jepsen, H Vilstrup, K Stengaard-Pedersen, J F Dahlerup
OBJECTIVE: Rheumatoid arthritis (RA) is an autoinflammatory disease caused by genetic susceptibility and environmental triggers, which include infectious agents. Helicobacter pylori, a bacterium that frequently colonizes the stomach, is associated with the development of certain autoinflammatory disorders. This study examined a possible association between H. pylori infection and RA. METHOD: This cohort study was performed in the Central Denmark Region. Patients were enrolled from primary healthcare centres after a urea breath test (UBT) for H...
July 17, 2018: Scandinavian Journal of Rheumatology
S D Kay, A L Carlsen, A Voss, M Burton, Acp Diederichsen, M K Poulsen, Nhh Heegaard
OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a high risk of atherosclerosis and cardiovascular disease (CVD). MicroRNAs (miRNAs) are small non-coding RNAs that modulate protein translation, and dysregulation is seen in autoimmunity, atherosclerosis, and CVD. We investigate associations between circulating miRNAs and markers of atherosclerosis in SLE patients. METHOD: A group (n = 121) of well-characterized SLE patients were screened for atherosclerosis by cardiac computed tomography and carotid ultrasound...
July 9, 2018: Scandinavian Journal of Rheumatology
C H Brahe, M Østergaard, J S Johansen, N Defranoux, X Wang, R Bolce, E H Sasso, L M Ørnbjerg, K Hørslev-Petersen, K Stengaard-Pedersen, P Junker, T Ellingsen, P Ahlquist, H Lindegaard, A Linauskas, A Schlemmer, M Y Dam, I Hansen, T Lottenburger, C Ammitzbøll, A Jørgensen, S B Krintel, J Raun, M L Hetland
OBJECTIVES: Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive protein (DAS28-CRP) remission and radiographic progression in the double-blinded OPERA trial. METHOD: Treatment-naïve RA patients (N = 180) with moderate or high DAS28 were randomized to methotrexate (MTX) + adalimumab (n = 89) or MTX + placebo (n = 91) in combination with glucocorticoid injection into swollen joints...
July 9, 2018: Scandinavian Journal of Rheumatology
A Onishi, Y Tanaka, A Morinobu
No abstract text is available yet for this article.
July 5, 2018: Scandinavian Journal of Rheumatology
A Bilberg, T Bremell, J Bjersing, K Mannerkorpi
OBJECTIVES: The aim of the study was to determine the prevalence of widespread pain (WP) in women with early rheumatoid arthritis (RA) and to compare physical function, activity limitations, health-related quality of life, mental distress, and disease activity between women with WP and non-widespread pain (NWP). METHOD: This cross-sectional study included 102 women with early RA. Participants were provided with self-reported questionnaires quantifying activity limitations, physical activity, pain intensity, health-related quality of life, and fatigue...
July 5, 2018: Scandinavian Journal of Rheumatology
A Valls-Ontañón, I Méndez-Manjón, O L Haas-Junior, V Ruiz-Magaz, F Hernández-Alfaro
No abstract text is available yet for this article.
July 2, 2018: Scandinavian Journal of Rheumatology
M Marshall, G Peat, E Nicholls, H L Myers, M A Mamas, D A van der Windt
OBJECTIVE: To determine whether selected metabolic factors are associated with greater amounts of radiographic hand osteoarthritis (OA) incidence and progression. METHODS: The study identified 706 adults, aged 50-69 years, with hand pain and hand radiographs at baseline, from two population-based cohorts. Metabolic factors (body mass index, hypertension, dyslipidaemia, and diabetes) were ascertained at baseline by direct measurement and medical records. Analyses were undertaken following multiple imputation of missing data, and in complete cases (sensitivity analyses)...
June 28, 2018: Scandinavian Journal of Rheumatology
P Jakorinne, M Haanpää, J Arokoski
OBJECTIVES: Quantitative sensory testing (QST) is a method to assess somatosensory function in osteoarthritis (OA), but reliability data on the performance of different QST modalities on different joint structures are missing. The main aims of our study were to assess intertester and intratester reliability of tactile detection thresholds (TDTs), vibration detection thresholds (VDTs), and pressure pain thresholds (PPTs) on different knee joint structures. METHOD: In total, 32 subjects with knee OA and 32 volunteers with healthy knees participated...
June 25, 2018: Scandinavian Journal of Rheumatology
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Scandinavian Journal of Rheumatology
C-R Wang, M-F Liu, C-T Weng, W-C Lin, W-T Li, H-W Tsai
OBJECTIVE: Despite aggressive therapeutic regimens, diffuse alveolar haemorrhage (DAH) is still associated with a high mortality rate in systemic lupus erythematosus (SLE). This study was carried out in patients with SLE-associated DAH with a focus on their therapeutic modality. METHOD: A retrospective review was performed in 839 Han Chinese lupus patients hospitalized for their DAH manifestation from May 2006 to December 2016. RESULTS: There were 24 episodes in 17 cases (2...
September 2018: Scandinavian Journal of Rheumatology
I Yokoe, H Kobayashi, Y Kobayashi, J T Giles, K Yoneyama, N Kitamura, M Takei
OBJECTIVE: To prospectively investigate the effect of tocilizumab (TCZ) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), as a predictor of congestive heart failure (CHF) in patients with active rheumatoid arthritis (RA). METHOD: Seventy patients with RA (median age 59 years, 86% female) free of cardiovascular disease were treated with TCZ and followed for 24 weeks. The NT-proBNP levels were measured at baseline and week 24. Thirty healthy controls were included for comparison of normal NT-proBNP levels with those of RA patients...
September 2018: Scandinavian Journal of Rheumatology
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
September 2018: Scandinavian Journal of Rheumatology
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