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Scandinavian Journal of Rheumatology

A Klein, I Becker, K Minden, I Foeldvari, J P Haas, G Horneff
OBJECTIVE: Adalimumab (ADA) has become a valuable treatment option for juvenile idiopathic arthritis (JIA). The importance of combination with methotrexate (MTX) is unclear. METHOD: Data from the German Biologics in Paediatric Rheumatology (BIKER) registry are reported. Response to treatment was analysed using JIA American College of Rheumatology (ACR) scores, 10-joint Juvenile Arthritis Disease Activity Score (JADAS10), and improvement of functional status and ACR inactive disease criteria...
November 9, 2018: Scandinavian Journal of Rheumatology
Z Kiuchi, M Ogura, M Sato, K Kamei, K Ishikura, J Abe, S Ito
No abstract text is available yet for this article.
November 8, 2018: Scandinavian Journal of Rheumatology
T Sakairi, N Sakurai, M Nakasatomi, H Ikeuchi, Y Kaneko, A Maeshima, Y Nojima, K Hiromura
OBJECTIVE: We aimed to describe the clinical characteristics and treatment course of hypertrophic pachymeningitis (HPM) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: We retrospectively analysed 15 patients (11 men and four women). HPM was diagnosed based on thickening and enhancing of the brain and/or spinal dura mater on gadolinium-enhanced magnetic resonance imaging (MRI) T1 sequence. RESULTS: The median age at HPM onset was 60 years...
November 5, 2018: Scandinavian Journal of Rheumatology
S Peytrignet, J Manning, E Wragg, T Moore, M Samaranayaka, G Dinsdale, A L Herrick
OBJECTIVE: The burden of disability associated with systemic sclerosis (SSc) is being increasingly recognized. Our aim was to test the hypothesis that changes in functional ability over time differ between patients with limited (lcSSc) and diffuse cutaneous (dcSSc) subtypes, and that in dcSSc (but not lcSSc) these changes correlate with skin thickening. METHOD: This was a retrospective analysis of data collected prospectively between 2005 and 2016 at a single centre...
November 5, 2018: Scandinavian Journal of Rheumatology
J Zhao, J Li, Z Zhang
OBJECTIVES: Idiopathic retroperitoneal fibrosis (iRPF) is an uncommon disease with inflammatory features. Most patients have good prognosis but some may relapse or even progress to chronic renal failure. The aims of the study were to investigate the prognosis of a large cohort of iRPF patients and explore the risk factors for poor outcomes. METHODS: All patients with a definite diagnosis of iRPF in Peking University First Hospital between 1 January 2003 and 31 December 2016 were enrolled...
September 30, 2018: Scandinavian Journal of Rheumatology
K Rebane, L Ristolainen, H Relas, T Orenius, H Kautiainen, R Luosujärvi, K Aalto, H Säilä
OBJECTIVES: To describe a cohort of Finnish juvenile idiopathic arthritis (JIA) patients, to recognize those young adults who are at risk of becoming socially restricted by their long-term rheumatic disease, and to assess which areas of self-rated health-related quality of life (HRQoL) are associated with the emergence of restricted social participation. METHODS: A total of 195 young adults with JIA completed questionnaires addressing demographics, health behaviour, physical activity, functional ability, HRQoL, depressive symptoms, and self-esteem...
September 30, 2018: Scandinavian Journal of Rheumatology
A M Nilsson, E Tufvesson, R Hesselstrand, P Olsson, P Wollmer, T Mandl
OBJECTIVE: Small airway disease and chronic obstructive pulmonary disease are common in primary Sjögren's syndrome (pSS). However, the underlying inflammatory mechanisms behind pSS-associated airway disease have not been studied in detail. We therefore wanted to study cytokine and leucocyte levels in induced sputum in never-smoking patients with pSS. METHOD: Induced sputum cytokines and leucocytes were assessed in 20 never-smoking patients with pSS and 19 age- and gender-matched population-based controls...
September 30, 2018: Scandinavian Journal of Rheumatology
N Molano-González, E Olivares-Martínez, J M Anaya, G Hernández-Molina
OBJECTIVE: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren's syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). METHOD: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren's syndrome, Sjögren's syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody - ACPA...
September 30, 2018: Scandinavian Journal of Rheumatology
T Matsuo, M Hashimoto, I Ito, T Kubo, R Uozumi, M Furu, H Ito, T Fujii, M Tanaka, C Terao, H Kono, M Mori, M Hamaguchi, W Yamamoto, K Ohmura, S Morita, T Mimori
OBJECTIVE: Serum interleukin-18 (IL-18) levels are increased in patients with interstitial lung disease (ILD). In addition, IL-18 levels are increased in patients with rheumatoid arthritis (RA) and are associated with arthritis activity. We determined whether increased IL-18 levels are associated with ILD in RA. METHOD: RA patients were enrolled using an RA cohort database. Plasma IL-18 levels were measured by enzyme-linked immunosorbent assay. ILD was determined by a pulmonologist and a radiologist based on chest radiography and computed tomography findings...
September 30, 2018: Scandinavian Journal of Rheumatology
L Massarenti, C Enevold, D Damgaard, N Ødum, C H Nielsen, S Jacobsen
OBJECTIVE: Peptidylarginine deiminase-4 (PAD4) is highly expressed by neutrophils and essential for citrullination occurring during the formation of neutrophil extracellular traps, which have been implicated in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Single-nucleotide polymorphisms (SNPs) in PADI4 influence PAD4 expression and functionality. Here, we investigate whether SNPs in PADI4 influence the risk of SLE or LN. METHOD: Altogether, 234 SLE patients and 484 controls were genotyped for nine PADI4 SNPs known to alter PAD4 functionality and/or expression, or to be associated with other autoimmune diseases, using an in-house multiplex Luminex assay...
September 30, 2018: Scandinavian Journal of Rheumatology
G De Luca, C Campochiaro, S Franchini, S Sartorelli, C Candela, G Peretto, S Sala, L Dagna
No abstract text is available yet for this article.
September 30, 2018: Scandinavian Journal of Rheumatology
W Shi, J Kang, B Lao, X Ye, F Zeng, J Wang, W Sun
No abstract text is available yet for this article.
September 30, 2018: Scandinavian Journal of Rheumatology
K Chatzidionysiou, G Lukina, C Gabay, M L Hetland, E M Hauge, K Pavelka, D Nordström, H Canhão, M Tomsic, Z Rotar, E Lie, T K Kvien, R F van Vollenhoven, S Saevarsdottir
OBJECTIVES: To investigate whether smoking habits predict response to rituximab (RTX) in rheumatoid arthritis (RA). METHOD: We included patients from the CERERRA international cohort receiving the first treatment cycle with available smoking status (n = 2481, smokers n = 528, non-current smokers n = 1953) and at least one follow-up visit. Outcome measures were change in Disease Activity Score based on 28-joint count (ΔDAS28) and European League Against Rheumatism (EULAR) good response at 6 months, with non-current smokers as the referent group...
September 27, 2018: Scandinavian Journal of Rheumatology
M Kawauchi, T Watanabe, T Hattori, A Suzuki, A Ishizu, S Jodo
No abstract text is available yet for this article.
August 28, 2018: Scandinavian Journal of Rheumatology
C S Moura, E Rahme, W P Maksymowych, M Abrahamowicz, L Bessette, S Bernatsky
OBJECTIVE: To assess the risk of hospitalized infection among initiators of disease-modifying anti-rheumatic drugs (DMARDs) and/or anti-tumour necrosis factor (anti-TNF) agents in ankylosing spondylitis (AS). METHOD: We studied AS patients, new users of anti-TNF drugs and/or DMARDs between 1 January 2001 and 31 December 2011. Cohort entry was defined as the date of first prescription of any of these drugs. We used Cox regression with three time-varying drug exposures: current use of DMARDs without biologics, current use of anti-TNF agents alone or in combination with DMARDs (anti-TNF ± DMARDs), and current non-use...
August 16, 2018: Scandinavian Journal of Rheumatology
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Scandinavian Journal of Rheumatology
C-R Wang, M-F Liu, C-T Weng, W-C Lin, W-T Li, H-W Tsai
OBJECTIVE: Despite aggressive therapeutic regimens, diffuse alveolar haemorrhage (DAH) is still associated with a high mortality rate in systemic lupus erythematosus (SLE). This study was carried out in patients with SLE-associated DAH with a focus on their therapeutic modality. METHOD: A retrospective review was performed in 839 Han Chinese lupus patients hospitalized for their DAH manifestation from May 2006 to December 2016. RESULTS: There were 24 episodes in 17 cases (2...
September 2018: Scandinavian Journal of Rheumatology
I Yokoe, H Kobayashi, Y Kobayashi, J T Giles, K Yoneyama, N Kitamura, M Takei
OBJECTIVE: To prospectively investigate the effect of tocilizumab (TCZ) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), as a predictor of congestive heart failure (CHF) in patients with active rheumatoid arthritis (RA). METHOD: Seventy patients with RA (median age 59 years, 86% female) free of cardiovascular disease were treated with TCZ and followed for 24 weeks. The NT-proBNP levels were measured at baseline and week 24. Thirty healthy controls were included for comparison of normal NT-proBNP levels with those of RA patients...
September 2018: Scandinavian Journal of Rheumatology
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
September 2018: Scandinavian Journal of Rheumatology
J K Pedersen, R Holst, J Primdahl, A J Svendsen, K Hørslev-Petersen
OBJECTIVES: To investigate mortality and its predictors in a retrospectively defined population-based rheumatoid arthritis (RA) inception cohort Method: We included patients ascertained with incident RA from a region in the southern part of Denmark from 1995 to 2002. All patients fulfilled the 1987 American College of Rheumatology criteria for RA. The patients were followed from RA classification until death, emigration, or end of follow-up on 31 December 2013. We used personal record linkage with national public registers to obtain information on education, employment, cohabitation, comorbidity, and vital status...
September 2018: Scandinavian Journal of Rheumatology
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