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Journal of Medical Primatology

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https://www.readbyqxmd.com/read/28727150/generalized-convulsive-seizures-are-associated-with-ketamine-anesthesia-in-a-rhesus-macaque-macaca-mulatta-undergoing-urodynamic-studies-and-transcutaneous-spinal-cord-stimulation
#1
Parag N Gad, Gregory W Salyards, Laura M Garzel, Kari L Christe, V Reggie Edgerton, Leif A Havton
A female rhesus macaque developed two episodes of generalized convulsions during transcutaneous spinal cord stimulation (TSCS) and urodynamic studies under ketamine anesthesia. The seizures took place in the absence of active TSCS and bladder pressure elevation. Ketamine anesthesia remains the primary risk factor for the convulsions during these experimental procedures.
July 20, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28703877/biochemical-and-hematological-evaluations-of-black-howler-monkeys-alouatta-pigra-in-highly-degraded-landscapes-in-mexico
#2
Luis M García-Feria, Colin A Chapman, Rosalía Pastor-Nieto, Juan Carlos Serio-Silva
BACKGROUND: Loss and fragmentation of Neotropical primates' habitat can alter the health and individual adaptation. Physiological parameters reflect health status and individuals responses to the habitat conditions. METHODS: We captured six wild adult females and six adult males of Alouatta pigra to evaluate their physical condition (body mass, respiratory and heart rate, and rectal temperature), hematology and blood chemistry on fragmentation habitat condition at southeastern Mexico...
July 13, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28671330/cytomegaloviral-hypophysitis-in-a-simian-immunodeficiency-virus-infected-rhesus-macaque-macacca-mulatta
#3
Melissa R Berg, Michael A Owston, Marie-Claire Gauduin, Basel T Assaf, Anne D Lewis, Edward J Dick
Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque...
July 3, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28671309/fatal-sv40-associated-pneumonia-and-nephropathy-following-renal-allotransplantation-in-rhesus-macaque
#4
M Song, M S Mulvihill, K D Williams, B H Collins, A D Kirk
Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we report SV40 viremia leading to fatal interstitial pneumonia in an immunosuppressed host following renal allotransplantation.
July 3, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28664555/hepatic-expression-of-cytochrome-p450-enzymes-in-non-human-primate-species
#5
Shotaro Uehara, Yasuhiro Uno, Hiroshi Yamazaki
Cytochromes P450 (P450) largely remain to be characterized in great apes. Comparative immunochemical detection of drug metabolizing forms of P450s 1A, 2A, 2B, 2C, 2D, 2E, 2J, 3A, 4A, and 4F in liver microsomes from chimpanzees, gorillas, orangutans, gibbons, cynomolgus and rhesus macaques, and common marmosets were carried out.
June 29, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28639374/snp-based-genetic-characterization-of-the-tulane-national-primate-research-center-s-conventional-and-specific-pathogen-free-rhesus-macaque-macaca-mulatta-populations
#6
Sree Kanthaswamy, Jillian Ng, Robert F Oldt, Kathrine Phillippi-Falkenstein, H Michael Kubisch
BACKGROUND: The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center (TNPRC) has one of the largest rhesus macaque breeding colonies in the United States. METHODS: SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry. RESULTS: Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation...
June 21, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28620920/diet-induced-early-stage-atherosclerosis-in-baboons-lipoproteins-atherogenesis-and-arterial-compliance
#7
Michael C Mahaney, Genesio M Karere, David L Rainwater, Venkata S Voruganti, Edward J Dick, Michael A Owston, Karen S Rice, Laura A Cox, Anthony G Comuzzie, John L VandeBerg
BACKGROUND: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. METHODS: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy...
June 16, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28585307/maternal-antibodies-against-tetanus-toxoid-do-not-inhibit-potency-of-antibody-responses-to-autologous-antigen-in-newborn-rhesus-monkeys
#8
Ronald S Veazey, Yingjie Lu, Huanbin Xu, Widade Ziani, Lara A Doyle-Meyers, Marion S Ratterree, Xiaolei Wang
BACKGROUND: Our previous study suggested newborns have competent immune systems with the potential to respond to foreign antigens and vaccines. In this study, we examined infant immune responses to tetanus toxoid (TT) vaccination in the presence of maternal antibody to TT. METHODS: We examined changes in plasma levels of tetanus toxoid-specific IgG1 (anti-TT IgG1) in a total of eight infant rhesus macaques from birth through 6 months of age using a commercial Monkey Anti-TT IgG1 ELISA kit...
June 6, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28573738/mucosal-bacterial-dissemination-in-a-rhesus-macaque-model-of-experimental-brucellosis
#9
Kasi E Russell-Lodrigue, Stephanie Z Killeen, Thomas A Ficht, Chad J Roy
Animals were experimentally infected with Brucella melitensis via aerosol. B. melitensis was cultured from the saliva and vaginal vault of infected animals, corresponding to bacterial dissemination in other target tissues. This is the first report of bacterial dissemination to these mucosal surfaces in a non-human primate model of brucellosis.
June 2, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28573661/characterization-of-a-pristane-induced-lupus-associated-model-in-the-non-human-primate-cynomolgus-monkey
#10
Jing Wang, Hui Shen, Yuqiang Zhu, Ying Zhu, Lei Cai, Zhiyao Wang, Qin Shi, Yuhua Qiu
BACKGROUND: Lupus is an autoimmune disease with complex syndrome. Rodent models have limitations for recapitulating the spectrum of the disease. A more powerful translational model is desirable. METHOD: Lupus-associated model in cynomolgus monkeys was induced by two intraperitoneal injections of 2, 6, 10, 14-tetramethylpentadecane (PRISTANE). Lupus-specific biomarkers and manifestations over a 246-day period were observed at multilevel. To visualize and quantify kidney function in real time, contrast-enhanced ultrasound was used...
June 2, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28561884/determination-of-vertebral-heart-score-in-three-species-of-spider-monkey-ateles-fusciceps-a-%C3%A2-hybridus-and-a-%C3%A2-paniscus
#11
Richard A Saunders, Marie Kubiak, Phillipa Dobbs
BACKGROUND: The vertebral heart score (VHS) is a method of evaluation of cardiac size well documented in domestic mammals and in other primate species, and the aim of this study was to determine the VHS in three species of Spider monkey. METHODS: In this retrospective study, right lateral radiographs of thirty clinically well animals were reviewed and VHS determined. The species included were Ateles fusciceps (n=17), Ateles hybridus (n=8) and Ateles paniscus (n=5)...
May 31, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28547839/thrombotic-thrombocytopenic-purpura-related-to-adamts13-deficiency-and-successful-treatment-in-a-chimpanzee-pan%C3%A2-troglodytes-verus
#12
Hester van Bolhuis, Marno Wolters, Mark de Boer, Rob Fijnheer, Martine van Zijll Langhout, Henk Niphuis, Carel Eckmann
A 27-year-old male chimpanzee (Pan troglodytes verus) developed signs of thrombotic thrombocytopenic purpura (TTP). ADAMTS13 deficiency appeared to be the cause of disease. After treatment with high-dose prednisone, haematological values and clinical signs recovered. This is the first description of spontaneous TTP associated with ADAMTS13 deficiency in a non-human primate.
May 26, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28543059/natural-pathology-of-the-captive-chimpanzee-pan-troglodytes-a-35-year-review
#13
REVIEW
Shyamesh Kumar, Hannah Laurence, Michael A Owston, R Mark Sharp, Priscilla Williams, Robert E Lanford, Gene B Hubbard, Edward J Dick
We present the spontaneous pathological lesions identified as a result of necropsy or biopsy for 245 chimpanzees (Pan troglodytes) over a 35-year period. A review of the pathology database was performed for all diagnoses on chimpanzees from 1980 to 2014. All morphologic diagnoses, associated system, organ, etiology, and demographic information were reviewed and analyzed. Cardiomyopathy was the most frequent lesion observed followed by hemosiderosis, hyperplasia, nematodiasis, edema, and hemorrhage. The most frequently affected systems were the gastrointestinal, cardiovascular, urogenital, respiratory, and lymphatic/hematopoietic systems...
May 23, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28543057/combination-of-kinematic-analyses-and-diffusion-tensor-tractrography-to-evaluate-the-residual-motor-functions-in-spinal-cord-hemisected-monkeys
#14
Can Zhao, Wei Song, Jia-Sheng Rao, Wen Zhao, Rui-Han Wei, Xia Zhou, Peng-Yu Tian, Zhao-Yang Yang, Xiao-Guang Li
BACKGROUND: Spinal cord injury (SCI) causes loss of locomotor functions. Nowadays, the relationship between the residual locomotion after SCI and the diffusion tensor tractography (DTT) results still remains unclear. METHODS: Four rhesus monkeys were suffered thoracic cord hemisection. Kinematic evaluation and DTT were performed prior- and post-SCI (6 and 12 weeks). The longitudinal changes of gait parameters and the DTT parameters were analyzed for the injury-contralateral hindlimb...
May 23, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28523858/clinical-signs-diagnostics-and-successful-treatment-of-a-myocarditis-in-an-adult-chimpanzee-pan-troglodytes
#15
Martine van Zijll Langhout, Marno Wolters, Katalin M Horvath, Harold Thiesbrummel, Paul Smits, Hester van Bolhuis, Victor van der Hulst, Robert Riezebos
A chimpanzee (Pan troglodytes) was presented with lethargic behaviour. Echocardiography and abnormal cardiac and inflammatory biomarkers revealed a myocarditis. The animal fully recovered after prolonged treatment with losartan and carvedilol. This is the first report of the diagnosis and successful treatment of myocarditis in this species.
May 19, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28523853/radiographic-evaluation-of-cardiac-silhouette-using-vertebral-heart-size-method-in-squirrel-monkey-saimiri-sciureus
#16
L N Coutinho, Mbs Brito, A A Imbeloni, Acc Lacreta, F Rech, M P Souto, Ira Ataíde
BACKGROUND: The Saimiri sciureus represents a valuable resource for biomedical research, due to its large number on primate centers and similarity to human anatomy and physiology. The aim of this study was to apply the method proposed by Buchanan & Bücheler in healthy squirrel monkeys (S. sciureus) and determine by radiographic examination, the average value of the vertebral heart size (VHS) for the specie. METHOD: Laterolateral left (LLL), laterolateral right (LLR), ventrodorsal (VD), and dorsoventral (DV) projections were used for radiographic examinations to evaluate the heart silhouette of S...
May 19, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28516457/computed-tomography-or-necropsy-diagnosis-of-multiple-bullae-and-the-treatment-of-pneumothorax-in-rhesus-macaques-macaca-mulatta
#17
Jong-Min Kim, Sungyoung Han, Jun-Seop Shin, Byoung-Hoon Min, Won Young Jeong, Ga Eul Lee, Min Sun Kim, Ju Eun Kim, Hyunwoo Chung, Chung-Gyu Park
Pulmonary bullae and pneumothorax have various etiologies in veterinary medicine. We diagnosed multiple pulmonary bullae combined with or without pneumothorax by computed tomography (CT) or necropsy in seven rhesus macaques (Macaca mulatta) imported from China. Two of seven rhesus macaques accompanied by pneumothorax were cured by fixation of ruptured lung through left or right 3rd intercostal thoracotomy. Pneumonyssus simicola, one of the etiologies of pulmonary bullae, was not detected from tracheobronchiolar lavage...
May 18, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28488731/development-of-a-rectal-sexually-transmitted-infection-sti-model-in-rhesus-macaques-using-chlamydia-trachomatis-serovars-e-and-l2
#18
Tara R Henning, Monica Morris, Shanon Ellis, Kristen Kelley, Christi Phillips, Jana Ritter, Tara Jones, Eli Nachamkin, Cheng Y Chen, Jaeyoung Hong, Joseph Kang, Dorothy Patton, Janet McNicholl, John Papp, Ellen N Kersh
BACKGROUND: Rectal STI coinfection models enhance the understanding of rectal HIV transmission risk factors. MATERIALS AND METHODS: Rhesus macaques (n=9) were exposed to one of three rectal Chlamydia trachomatis (CT) challenges: C. trachomatis L2 (CT-L2 ); C. trachomatis serovar E (CT-E), followed by CT-L2 ; or CT-E, treatment/clearance, then CT-L2 . Infections were monitored by PCR. Weekly blood and rectal secretion/lavage samples were collected for cytokine analyzes and/or epithelial sloughing, occult, and overt blood determinations...
May 10, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28488364/comparison-of-the-vaginal-environment-in-rhesus-and-cynomolgus-macaques-pre-and-post-lactobacillus-colonization
#19
Gregory J Daggett, Chunxia Zhao, Fawn Connor-Stroud, Patricia Oviedo-Moreno, Hojin Moon, Michael W Cho, Thomas Moench, Deborah J Anderson, Francois Villinger
BACKGROUND: Rhesus and cynomologus macaques are valuable animal models for the study of human immunodeficiency virus (HIV) prevention strategies. However, for such studies focused on the vaginal route of infection, differences in vaginal environment may have deterministic impact on the outcome of such prevention, providing the rationale for this study. METHODS: We tested the vaginal environment of rhesus and cynomolgus macaques longitudinally to characterize the normal microflora based on Nugent scores and pH...
May 9, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28464359/fatty-acid-supplements-improve-hair-coat-condition-in-rhesus-macaques
#20
A F Hamel, M T Menard, M A Novak
As captive rhesus macaques often exhibit hair loss, alopecia was quantified and behavior was recorded before, during, and after fatty acid supplementation in six macaques. Fatty acid treatment was associated with a decrease in alopecia and in self-grooming behavior. Therefore, fatty acids may be a viable treatment for alopecia in some captive primates.
May 2, 2017: Journal of Medical Primatology
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