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Japanese Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/30020510/a-randomized-open-label-phase-iii-trial-of-pertuzumab-retreatment-in-her2-positive-locally-advanced-metastatic-breast-cancer-patients-previously-treated-with-pertuzumab-trastuzumab-and-chemotherapy-the-japan-breast-cancer-research-group-m05-precious-study
#1
Yutaka Yamamoto, Hiroji Iwata, Takayuki Ueno, Naruto Taira, Masahiro Kashiwaba, Masato Takahashi, Hiroshi Tada, Koichiro Tsugawa, Tatsuya Toyama, Naoki Niikura, Fumikata Hara, Tomomi Fujisawa, Tetsuhiro Yoshinami, Shigehira Saji, Toshimi Takano, Norikazu Masuda, Satoshi Morita, Masakazu Toi, Shinji Ohno
The PRECIOUS study (UMIN000018202) is being conducted as a multicenter, randomized, open-label Phase III study to determine if retreatment with pertuzumab is more effective than conventional treatment in HER2-positive locally advanced (LA)/metastatic breast cancer (MBC) patients previously treated with pertuzumab, trastuzumab and chemotherapy. Patients are randomized 1:1 into chemotherapy plus trastuzumab with or without pertuzumab groups. The latest regimen before enrollment did not include pertuzumab, and the number of previous chemotherapy regimens for LA/MBC did not exceed three...
July 18, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30007338/prostate-cancer-incidence-rates-in-the-world-from-the-cancer-incidence-in-five-continents-xi
#2
Kumiko Saika, Ryoko Machii
No abstract text is available yet for this article.
July 11, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29982601/clinicopathologic-features-and-brca-mutations-in-primary-fallopian-tube-cancer-in-japanese-women
#3
Shoko Sakurada, Yoh Watanabe, Hideki Tokunaga, Fumiaki Takahashi, Hidekazu Yamada, Kazuhiro Takehara, Nobuo Yaegashi
Objective: The present study aimed to clarify the clinicopathological features, including the level of p53 protein expression and BRCA mutations, of primary fallopian tube cancer (PFTC) in Japanese women. Methods: A multicenter clinical survey was conducted at three Japanese institutions. Clinical data in patients with PFTC between 1998 and 2016 were collected. Immunohistochemical staining of p53 and BRCA mutation analysis by exome sequence using paraffin-embedded surgical resected specimens were performed...
July 2, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29939297/the-investigation-study-using-a-questionnaire-about-the-employment-of-japanese-breast-cancer-patients
#4
Haruru Kotani, Ayumi Kataoka, Kayoko Sugino, Madoka Iwase, Sakura Onishi, Yayoi Adachi, Naomi Gondo, Akiyo Yoshimura, Masaya Hattori, Masataka Sawaki, Hiroji Iwata
Background: Breast cancer is the most common cancer among women, and its survival rate has improved. As the number of cancer survivors increases, it is important to support their social comeback during and after treatment. Methods: Questionnaires were distributed to breast cancer patients treated in Aichi Cancer Center Hospital between June and November 2014. Responders were categorized according to adjuvant therapy (Group A: none, Group B: endocrine therapy, Group C: chemotherapy), or if they had advanced or recurrent breast cancer (Group D)...
June 25, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29939285/outcome-and-prognostic-factors-in-metastatic-urothelial-carcinoma-patients-receiving-second-line-chemotherapy-an-analysis-of-real-world-clinical-practice-data-in-japan
#5
Ryuji Matsumoto, Takashige Abe, Junji Ishizaki, Hiroshi Kikuchi, Toru Harabayashi, Keita Minami, Ataru Sazawa, Tango Mochizuki, Tomoshige Akino, Masashi Murakumo, Takahiro Osawa, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Objectives: The objective of the present study was to investigate the survival outcome and prognostic factors of metastatic urothelial carcinoma patients treated with second-line systemic chemotherapy in real-world clinical practice. Methods: Overall, 114 patients with metastatic urothelial carcinoma undergoing second-line systemic chemotherapy were included in this retrospective analysis. The dominant second-line chemotherapy was a paclitaxel-based combination regimen (60%, 68/114)...
June 25, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931084/palliative-pain-relief-and-safety-of-percutaneous-radiofrequency-ablation-combined-with-cement-injection-for-bone-metastasis
#6
Wei Zhao, Hui Wang, Ji-Hong Hu, Zhao-Hong Peng, Jin-Zhou Chen, Jian-Qiang Huang, Yong-Neng Jiang, Gang Luo, Gen-Fa Yi, Jin Shen, Bu-Lang Gao
Purpose: To investigate the pain relief effect and safety of percutaneous radiofrequency ablation (RFA) with a multitined electrode combined with cement injection in patients with painful metastatic bone tumors. Materials and methods: Sixteen patients with 34 osteolytic metastatic lesions were treated with RFA including 4 males and 12 females (age range 54-84). Thirteen patients with spinal metastases received additional cement injection. Medical imaging, a visual analog scale (VAS) and the EORTC QLQ-C30 were performed to evaluate the metastatic lesion, pain and quality of life, respectively, before and after RFA and at follow-ups...
June 20, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931296/breast-cancer-incidence-rates-in-the-world-from-the-cancer-incidence-in-five-continents-xi
#7
Kota Katanoda, Megumi Hori
No abstract text is available yet for this article.
June 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931295/prognostic-factors-of-non-ampullary-duodenal-adenocarcinoma
#8
Teijiro Hirashita, Masayuki Ohta, Kazuhiro Tada, Kunihiro Saga, Hiroomi Takayama, Yuichi Endo, Hiroki Uchida, Yukio Iwashita, Masafumi Inomata
Background: Non-ampullary duodenal adenocarcinoma, excluding carcinoma in the ampulla of Vater, is a rare disease. Although several prognostic factors have been reported, they remain controversial due to the rarity of non-ampullary duodenal adenocarcinoma. The aims of this study were to investigate prognostic factors in patients with non-ampullary duodenal adenocarcinoma and to assess chemotherapy in patients with recurrence. Patients and methods: Records of 25 patients who underwent surgical treatment for non-ampullary duodenal adenocarcinoma from 2004 to 2016 were retrospectively reviewed...
June 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931182/factors-predicting-biochemical-recurrence-after-radical-prostatectomy-among-patients-with-clinical-t3-prostate-cancer
#9
Masafumi Otsuka, Tomohiko Kamasako, Toshihiro Uemura, Nobushige Takeshita, Tetsuo Shinozaki, Masayuki Kobayashi, Atsushi Komaru, Satoshi Fukasawa
Background: The effectiveness of cancer control is unclear after radical prostatectomy for patients with clinical T3 prostate cancer. Methods: We retrospectively reviewed 1409 patients who underwent radical prostatectomy between April 2007 and December 2014, including 210 patients with cT3 prostate cancer. Nine patients who received neoadjuvant hormonal therapy and three patients who were lost to follow-up were excluded from the analysis. Clinical staging was performed by an experienced radiologist using preoperative magnetic resonance imaging findings...
June 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931077/incidence-and-location-of-positive-surgical-margin-among-open-laparoscopic-and-robot-assisted-radical-prostatectomy-in-prostate-cancer-patients-a-single-institutional-analysis
#10
Atsushi Koizumi, Shintaro Narita, Taketoshi Nara, Koichiro Takayama, Sohei Kanda, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, Mingguo Huang, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, Hiroshi Nanjo, Tomonori Habuchi
Objective: To evaluate the positive surgical margin rates and locations in radical prostatectomy among three surgical approaches, including open radical prostatectomy, laparoscopic radical prostatectomy and robot-assisted radical prostatectomy. Methods: We retrospectively reviewed clinical outcomes at our institution of 450 patients who received radical prostatectomy. Multiple surgeons were involved in the three approaches, and a single pathologist conducted the histopathological diagnoses...
June 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29901731/characteristic-response-to-carboplatin-plus-paclitaxel-protein-bound-after-pembrolizumab
#11
Midori Nakamura, Keishi Oda, Fumihiro Tanaka, Kazuhiro Yatera
No abstract text is available yet for this article.
June 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29901705/phase-iii-study-of-watchful-waiting-vs-rituximab-as-first-line-treatment-in-advanced-stage-follicular-lymphoma-with-low-tumour-burden-jcog1411-flora-study
#12
Kenichi Miyamoto, Noriko Fukuhara, Dai Maruyama, Taro Shibata, Kenichi Nakamura, Kenichi Ishizawa, Kunihiro Tsukasaki, Hirokazu Nagai
A randomized phase III trial comparing watchful waiting with first-line rituximab for advanced stage follicular lymphoma commenced in Japan in December 2016. Watchful waiting is the current standard treatment for stages III and IV (Ann Arbor classification) follicular lymphoma with low tumour burden. This study aimed to confirm the superiority of early administration of first-line rituximab in terms of event-free survival to watchful waiting for stages III and IV follicular lymphoma with low tumour burden. A total of 290 patients will be accrued from 50 Japanese institutions within 5 years...
June 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29893894/new-developments-in-systemic-therapy-for-advanced-biliary-tract-cancer
#13
Chigusa Morizane, Makoto Ueno, Masafumi Ikeda, Takuji Okusaka, Hiroshi Ishii, Junji Furuse
Biliary tract cancer, carcinoma of the extrahepatic bile ducts, carcinoma of the gall bladder, ampullary carcinoma and intrahepatic cholangiocarcinoma are often identified at an advanced stage and have poor prognoses. Although effective chemotherapy regimens are needed, their development remains unsatisfactory. From the results of a phase III clinical trial (ABC-02 trial), gemcitabine plus cisplatin is the standard first-line chemotherapeutic regimen for advanced biliary tract cancer. A phase III trial of gemcitabine plus cisplatin vs...
June 11, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29893883/effect-of-continuous-intravenous-oxycodone-infusion-in-opioid-na%C3%A3-ve-cancer-patients-with-dyspnea
#14
Yoshihiro Yamamoto, Hiroaki Watanabe, Aina Sakurai, Yuko Deguchi, Shigeki Hirano, Yoshimi Okumura, Akiko Kumon, Norio Watanabe, Takashi Osada, Keiko Yamamura, Takuya Odagiri
Aim: Dyspnea is among symptoms that decrease quality of life for terminal cancer patients. There are few reports of the positive effects of oxycodone for the treatment of dyspnea, and no studies have focused on opioid-naïve patients. This study aimed to determine the efficacy and safety of continuous intravenous oxycodone infusion for opioid-naïve cancer patients with dyspnea. Methods: Eligible patients were opioid-naïve cancer inpatients who received continuous oxycodone infusion as a treatment for dyspnea under the care of the palliative care team at Komaki City Hospital between November 2013 and December 2016...
June 11, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29893861/mucositis-with-anti-egfr-monoclonal-antibody-in-cancer-patients-a-meta-analysis-of-randomized-controlled-trials
#15
Jing Li, Jing Xie
Background: The mucositis of anti-epidermal growth factor receptor monoclonal antibodies was poorly understood. We conducted this systematic review to fully investigate the mucositis of anti-epidermal growth factor receptor monoclonal antibodies in cancer patients. Study design: EMBASE, MEDLINE and PubMed were searched for articles published till December 2017. The relevant randomized controlled trials in cancer patients treated with anti-epidermal growth factor receptor monoclonal antibodies were retrieved and the systematic evaluation was conducted...
June 11, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29889250/prevalence-and-molecular-characteristics-of-defective-mismatch-repair-epithelial-ovarian-cancer-in-a-japanese-hospital-based-population
#16
Yusuke Tajima, Hidetaka Eguchi, Noriyasu Chika, Tomonori Nagai, Sariya Dechamethakun, Kensuke Kumamoto, Tetsuhiko Tachikawa, Kiwamu Akagi, Jun-Ichi Tamaru, Hiroyuki Seki, Yasushi Okazaki, Hideyuki Ishida
Background: The prevalence and molecular characteristics of defective mismatch repair epithelial ovarian cancers in the Japanese population have scarcely been investigated. Methods: Immunohistochemistry for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) was performed in formalin-fixed paraffin-embedded sections prepared from resected primary epithelial ovarian cancers in patients who underwent oophorectomy at our institution between April 2005 and September 2014...
June 8, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29741702/prognosis-of-metastatic-giant-cell-tumor-of-bone-in-the-pre-denosumab-era-a-systematic-review-and-a-meta-analysis
#17
Boris Itkin, Samanta Straminsky, Gabriela De Ronato, Daniel Lewi, Adolfo Marantz, Ariel Bardach
Background: Data on long-term prognosis of metastatic GCT (mGCT) is scant. The frequency of spontaneous regressions (SRs) is unknown. We aimed to estimate the prognosis of mGCT. Methods: We searched electronic scientific literature databases and generic Internet from January 1980 to August 2017. After identifying eligible studies we performed descriptive analyses and meta-analyses to estimate overall survival (OS), disease specific survival (DSS) and frequency of SRs in the years before the widespread use of denosumab...
May 5, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29733363/bacillus-calmette-gu%C3%A3-rin-may-have-clinical-benefit-for-glandular-or-squamous-differentiation-in-non-muscle-invasive-bladder-cancer-patients-retrospective-multicenter-study
#18
Wakako Yorozuya, Naotaka Nishiyama, Tetsuya Shindo, Yuki Kyoda, Naoki Itoh, Shintaro Sugita, Tadashi Hasegawa, Naoya Masumori
Objectives: To clarify the efficacy of intravesical Bacillus Calmette-Guérin (BCG) instillation for non-muscle invasive bladder (NMIBC) cancer with variant histology, especially glandular differentiation or squamous differentiation. Materials and methods: From May 1991 through June 2016, 53 patients were diagnosed retrospectively as having NMIBC with variant histology. Among these patients, 47 NMIBC patients with squamous differentiation or glandular differentiation were analyzed for this study...
May 4, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29718274/clinical-usefulness-of-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-for-assessing-early-oral-squamous-cell-carcinoma-ct1-2n0m0
#19
Emi Yamaga, Akira Toriihara, Shin Nakamura, Sakurako Asai, Tomoyuki Fujioka, Ryoichi Yoshimura, Yasuyuki Michi, Hiroyuki Harada, Ukihide Tateishi
Background: Positron emission tomography with 2-deoxy-2-[18F] fluoro-d-glucose integrated with computed tomography (FDG-PET/CT) is a useful method to evaluate patients with oral squamous cell carcinoma (OSCC). However, the prognostic significance of FDG-PET/CT for assessing early OSCC remains unclear. Methods: Pretreatment FDG-PET/CT of 205 consecutive patients (125 men, 80 women, mean age 59.7 year old) with early OSCC (cT1-2N0M0) between June 2010 and December 2014 were retrospectively analyzed...
April 28, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29889263/update-version-of-the-japanese-guidelines-for-gastric-cancer-screening
#20
Chisato Hamashima
Background: Although the incidence and mortality of gastric cancer have gradually decreased, its burden remains in East Asian countries. Gastric cancer screening has been performed in Japan since 1983, and the introduction of new screening techniques has been eagerly anticipated. Objective: To promote evidence-based screening, the Japanese guidelines for gastric cancer screening have been revised based on the new studies. Methods: The guidelines for gastric cancer screening have been developed according to a previously established method...
July 1, 2018: Japanese Journal of Clinical Oncology
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