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Japanese Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/28633504/a-phase-ii-study-of-palonosetron-aprepitant-dexamethasone-and-olanzapine-for-the-prevention-of-cisplatin-based-chemotherapy-induced-nausea-and-vomiting-in-patients-with-thoracic-malignancy
#1
Kazuhisa Nakashima, Haruyasu Murakami, Kouichi Yokoyama, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Tateaki Naito, Fumie Nishiyama, Mami Kikugawa, Masayo Kaneko, Yumiko Iwamoto, Satomi Koizumi, Keita Mori, Takeshi Isobe, Toshiaki Takahashi
Background: The three-drug combination of a 5-hydroxytryptamine type 3 receptor antagonist, a neurokinin 1 receptor antagonist and dexamethasone is recommended for patients receiving highly emetogenic chemotherapy. However, standard antiemetic therapy is not completely effective in all patients. Methods: We conducted an open-label, single-center, single-arm Phase II study to evaluate the efficacy of olanzapine in combination with standard antiemetic therapy in preventing chemotherapy-induced nausea and vomiting in patients with thoracic malignancy receiving their first cycle of cisplatin-based chemotherapy...
June 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28633481/adherence-to-oral-chemotherapy-medications-among-gastroenterological-cancer-patients-visiting-an-outpatient-clinic
#2
Chieko Hirao, Naoko Mikoshiba, Tomomi Shibuta, Reiko Yamahana, Aki Kawakami, Ryosuke Tateishi, Hironori Yamaguchi, Kazuhiko Koike, Noriko Yamamoto-Mitani
Objective: The purpose of this study was to investigate medication adherence to oral chemotherapy medications and determinants of medication non-adherence to them among gastroenterological cancer patients. Methods: A cross-sectional study was conducted on 117 consecutive, consenting, eligible patients visiting an outpatient clinic of university hospital in Japan. Good medication adherence was defined as taking 100% of the prescribed dose. Medication adherence was measured via self-report...
June 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28637282/the-effect-of-predisposing-atheroembolic-risk-factors-on-renal-functional-recovery-between-laparoscopy-and-open-technique-in-patients-with-t1-stage-renal-cell-carcinoma-who-underwent-partial-nephrectomy-a-retrospective-comparison-study
#3
Sung Han Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
Objective: The present study aimed to determine the effect of an increasing number of predisposing atheroembolic risk factors on the development of chronic kidney disease (CKD) after partial nephrectomy (PN) in patients with T1-stage renal cell carcinoma (RCC). Methods: The study included 147 patients with T1-stage RCC with a normal contralateral kidney and without preoperative CKD, who underwent open (OPN, N = 83, 56.5%) or laparoscopic PN (LPN, N = 64, 43.5%) between 2003 and 2014...
June 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28595360/distress-from-changes-in-physical-appearance-and-support-through-information-provision-in-male-cancer-patients
#4
Keiko Nozawa, Makiko Tomita, Eriko Takahashi, Shoko Toma, Yasuaki Arai, Miyako Takahashi
Objective: This study aims to reveal the present situation of changes in physical appearance induced by treatment, the effects of these changes on social activities, and support from medical staff in male cancer patients. Methods: A questionnaire survey was administered to 949 male patients (response rate: 90.1%) visiting the National Cancer Center Hospital in Tokyo over 3 days in January 2015. Results: The final respondents were 823 patients (mean age: 65...
June 8, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591864/optimism-pessimism-and-self-efficacy-in-female-cancer-patients
#5
Maik Thieme, Jens Einenkel, Markus Zenger, Andreas Hinz
Objective: The aim of this examination was to study whether psychological resource variables (optimism and self-efficacy) decrease when cancer is present and to test the predictive power of these variables for anxiety, depression and quality of life (QoL). Methods: The patient sample was comprised of 354 German women suffering from breast cancer or gynecological cancer. Participants filled in the resource assessment tools Life Orientation Test-Revised and the General Self-Efficacy Scale as well as the Hospital Anxiety and Depression Scale, the Patient Health Questionnaire-4 and the QoL instrument EORTC QLQ-C30 at two time points: (t1) during patients' hospital stay and (t2) 3 months later...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591845/severe-esophagitis-associated-with-cytomegalovirus-during-concurrent-chemoradiotherapy-for-esophageal-cancer
#6
Rihito Aizawa, Shigemi Matsumoto, Yu Uneno, Yoshitaka Nishikawa, Yoshinao Ozaki, Yukiko Mori, Masashi Kanai, Yuichi Ishida, Katsuyuki Sakanaka, Masahiro Hiraoka, Manabu Muto
Although radiation esophagitis is one of the most common adverse events that occurs during chemoradiotherapy (CRT) in patients with esophageal cancer, CRT-associated cytomegalovirus (CMV) esophagitis is rare. CMV esophagitis typically occurs in patients with an immunosuppressed status. Here we report a case of CMV esophagitis during CRT initially treated as radiation esophagitis. A 64-year-old man with mid-thoracic esophageal cancer was admitted to our hospital with clinical stage cT4bN1M1 (supraclavicular lymph node metastasis) Stage IV according to the UICC ver...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591818/yokukansan-for-the-treatment-of-preoperative-anxiety-and-postoperative-delirium-in-colorectal-cancer-patients-a-retrospective-study
#7
Saho Wada, Hironobu Inoguchi, Takatoshi Hirayama, Yutaka J Matsuoka, Yosuke Uchitomi, Hiroki Ochiai, Shunsuke Tsukamoto, Dai Shida, Yukihide Kanemitsu, Ken Shimizu
Background: Yokukansan (YKS), a Japanese traditional herbal medicine for neurosis and insomnia, is speculated to be useful for perioperative psychiatric symptoms in cancer patients, but there exists little empirical evidence. This study provides preliminary data about the efficacy, feasibility, and side effects of YKS for the treatment of preoperative anxiety and postoperative delirium in cancer patients. Methods: We retrospectively reviewed the medical records of colorectal cancer patients who took YKS for preoperative anxiety, evaluating the following: (1) patient characteristics, (2) feasibility of taking YKS, (3) changes in preoperative anxiety based on the Clinical Global Impression (CGI) scale and Edmonton Symptom Assessment System-revised (ESAS-r-anxiety), (4) incidence of postoperative delirium and (5) YKS-related side effects...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591817/efficacy-of-radiotherapy-for-primary-tumor-in-patients-with-unresectable-pancreatic-neuroendocrine-tumors
#8
Tomoyuki Iwata, Hideki Ueno, Jun Itami, Yoshinori Ito, Koji Inaba, Chigusa Morizane, Shunsuke Kondo, Yasunari Sakamoto, Satoshi Shiba, Mitsuhito Sasaki, Futa Koga, Takuji Okusaka
Background: Detailed information regarding the clinical efficacy of radiotherapy (RT) for primary tumor in patients with unresectable pancreatic neuroendocrine tumors (pNETs) is unknown. We therefore performed a retrospective study to evaluate the efficacy and safety of RT for primary pancreatic tumors in patients with pNETs. Methods: We investigated 11 patients with pNETs who received RT to the primary site between January 1997 and June 2015. Seven patients had Grade 2 neuroendocrine tumors (NET-G2) and four had neuroendocrine carcinoma (NEC) according to the 2010 WHO histopathological classification...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591816/is-preoperative-spirometry-a-predictive-marker-for-postoperative-complications-after-colorectal-cancer-surgery
#9
Yuki Tajima, Masashi Tsuruta, Masashi Yahagi, Hirotoshi Hasegawa, Koji Okabayashi, Kohei Shigeta, Takashi Ishida, Yuko Kitagawa
Background: Spirometry is a basic test that provides much information about pulmonary function; it is performed preoperatively in almost all patients undergoing colorectal cancer (CRC) surgery in our hospital. However, the value of spirometry as a preoperative test for CRC surgery remains unknown. The aim of this study was to determine whether spirometry is useful to predict postoperative complications (PCs) after CRC surgery. Methods: The medical records of 1236 patients who had preoperative spirometry tests and underwent CRC surgery between 2005 and 2014 were reviewed...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591777/mir-582-5p-inhibits-invasion-and-migration-of-salivary-adenoid-cystic-carcinoma-cells-by-targeting-foxc1
#10
Wei-Wei Wang, Bin Chen, Cheng-Bin Lei, Guo-Xin Liu, Ye-Gang Wang, Chen Yi, You-Yuan Wang, Shan-Yi Zhang
Objective: Neurotropism of salivary adenoid cystic carcinoma (SACC) and pulmonary metastasis may lead to in treatment failure. miR-582-5p plays important roles in tumorigenesis, invasion and migration. Here, we aim to determine the effect of miR-582-5p and its role in SACC invasion and metastasis. Methods: Six primary human SACC samples and matching adjacent normal tissues were analyzed by microarray analysis. Next, quantitative real-time PCR was carried out to evaluate miR-582-5p expression in 16 primary human SACC samples and matching adjacent normal tissues...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28582510/a-phase-1-study-evaluating-amg-337-in-asian-patients-with-advanced-solid-tumors%C3%A2
#11
Hirofumi Yasui, Ning Go, Hui Yang, Benny M Amore, A Scott Jung, Toshihiko Doi
AMG 337, a selective small-molecule MET inhibitor, was evaluated in Asian patients with advanced solid tumors. Eligible patients orally self-administered AMG 337; the initial dose of 150 mg once daily (QD) was escalated to 300 mg QD (modified 3+3+3 design). Treatment continued until disease progression, intolerability, or death. The primary endpoint was adverse events (AEs) and clinical abnormalities defined as dose-limiting toxicities (DLTs). Secondary endpoints included other AEs, pharmacokinetics and tumor response...
June 5, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28541571/childhood-adolescent-and-young-adult-cancer-incidence-in-japan-in-2009-2011
#12
Kota Katanoda, Akiko Shibata, Tomohiro Matsuda, Megumi Hori, Kayo Nakata, Yoshitaka Narita, Chitose Ogawa, Wataru Munakata, Akira Kawai, Hiroshi Nishimoto
Little is known about cancer incidence among children and youths in Japan. We aimed to describe cancer incidence in Japan focusing on childhood, adolescence and young adulthood (AYA). Cancer incidence data were obtained from the Monitoring of Cancer Incidence in Japan project. For the 2009-2011 incidence, the data were collected from 40 prefectures, of which data from 27 prefectures meeting quality standards were analyzed (population coverage: 38.6%). Cancers diagnosed in 0-39 years of age were classified according to the International Classification of Childhood Cancer (version 3)...
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28541555/effective-chemomobilization-with-etoposide-and-cytarabine-ec-regimen-in-lymphoma-patients-a-single-center-retrospective-observational-study
#13
Daisuke Koyama, Satoshi Nishiwaki, Yasuhiko Harada, Satomi Yamamoto, Shingo Kurahashi, Takumi Sugimoto, Toshihiro Iwasaki, Isamu Sugiura
Objective: Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen). Methods: We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013...
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28541495/increased-stathmin-in-serum-as-a-potential-tumor-marker-for-lung-adenocarcinoma
#14
Rong Biaoxue, Liu Hua, Fu Tian, Gao Wenlong
No abstract text is available yet for this article.
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28541474/postmarketing-surveillance-study-of-erlotinib-plus-gemcitabine-for-pancreatic-cancer-in-japan-polaris-final-analysis
#15
Junji Furuse, Akihiko Gemma, Wataru Ichikawa, Takuji Okusaka, Akihiro Seki, Tadashi Ishii
Objective: Erlotinib plus gemcitabine is approved in Japan for the treatment of metastatic pancreatic cancer. The POLARIS surveillance study investigated safety (focusing on interstitial lung disease [ILD]) and efficacy of erlotinib plus gemcitabine in Japanese pancreatic cancer patients. Methods: Patients receiving erlotinib plus gemcitabine for pancreatic cancer in Japan between July 2011 and August 2012 were enrolled. ILD-like events were independently confirmed by a review committee...
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28531325/up-regulated-microrna-299-corrected-with-poor-prognosis-of-glioblastoma-multiforme-patients-by-targeting-ell2
#16
Qian Huang, Xin-Wen Zhang, Yu-Shui Ma, Gai-Xia Lu, Ru-Ting Xie, Hui-Qiong Yang, Zhong-Wei Lv, Xiao-Ming Zhong, Tao Liu, Shi-Xiong Huang, Da Fu, Chun Xie
Background: An increasing understanding of the genes and molecular pathways of glioblastoma multiforme (GBM) can provide us a useful insight for the development of more effective targeted therapeutic. Methods: To investigate the expression and clinical significance of miR-299 and its target genes in GBM, the expression levels of miR-299 and its target gene in human normal brain tissues and GBM were analyzed in silico using genes microarray and hierarchical clustering analysis followed by validation with quantitative RT-PCR...
May 20, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28531292/perceived-social-support-and-its-impact-on-depression-and-health-related-quality-of-life-a-comparison-between-cancer-patients-and-general-population
#17
Hyosang Yoo, Dong Wook Shin, Ansuk Jeong, So Young Kim, Hyung-Kook Yang, Jun Suk Kim, Ji Eun Lee, Jae Hwan Oh, Eun-Cheol Park, Keeho Park, Jong-Hyock Park
Objective: It is well known that cancer patients' perception of social support is associated with their depressive symptoms and health-related quality of life. However, there have been little studies that compared the variates of cancer patients with the general population. We sought to compare differences in the level of perceived social support and the impact of perceived social support on depressive symptoms and health-related quality of life between cancer survivors and the general population...
May 20, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28531278/cardiovascular-toxic-effects-of-targeted-cancer-therapy
#18
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Over the past decade, there has been a major shift in chemotherapy from non-specific cytotoxic drugs to molecular targeted drug therapies. As more molecular targeted therapies are developed, new types of cardiovascular toxicities induced by targeted therapies are a growing problem. Cardiotoxicity induced by the human epidermal growth factor receptor-2 inhibitor trastuzumab manifests as decreased left ventricular ejection fraction. In contrast to anthracycline treatment, most cardiac events occur during trastuzumab treatment, but are reversed quickly when treatment is interrupted and cardiac intervention is established...
May 20, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28505354/psychological-distress-in-men-with-prostate-cancer-and-their-partners-before-and-after-cancer-diagnosis-a-longitudinal-study
#19
Akira Oba, Naoki Nakaya, Kumi Saito-Nakaya, Masaru Hasumi, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu
Objective: To examine the relative risk of psychological distress of men with prostate cancer and their partners during the period before and after prostate cancer diagnosis compared with men without prostate cancer and their partners. Methods: The participants reported questionnaires on psychological distress at four time points: before prostate cancer biopsy, and at 1, 3 and 6 months following prostate cancer diagnosis. We performed multiple logistic regression analyses to examine the relative risk of psychological distress...
May 15, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28505345/cardio-oncology-a-multidisciplinary-approach-for-detection-prevention-and-management-of-cardiac-dysfunction-in-cancer-patients
#20
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Cardiac dysfunction that develops during or after completion of cancer therapy is a growing health concern that should be addressed in a multidisciplinary setting. Cardio-oncology is a new discipline that focuses on screening, monitoring and treating cardiovascular disease during and after cancer treatment. A baseline cardiovascular risk assessment is essential. For high-risk patients, a tailored and detailed plan for cardiovascular management throughout treatment and beyond should also be established. Anthracycline and/or trastuzumab-containing chemotherapy and chest-directed radiation therapy are well known cardiotoxic cancer therapies...
May 15, 2017: Japanese Journal of Clinical Oncology
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