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Japanese Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/27908980/phase-2-study-of-eribulin-in-patients-with-previously-treated-advanced-or-metastatic-soft-tissue-sarcoma
#1
Akira Kawai, Nobuhito Araki, Yoichi Naito, Toshifumi Ozaki, Hideshi Sugiura, Yasuo Yazawa, Hideo Morioka, Akihiko Matsumine, Kenichi Saito, Shun Asami, Kazuo Isu
OBJECTIVE: Eribulin, a microtubule dynamics inhibitor, is approved for the treatment of patients with breast cancer and soft tissue sarcoma. We investigated the efficacy and safety of eribulin in Japanese patients with soft tissue sarcoma. METHODS: This open-label, multicenter, nonrandomized, Phase 2 study enrolled Japanese patients with measurable, advanced/metastatic soft tissue sarcoma of high/intermediate grade and ≥1 prior chemotherapy for advanced disease...
December 1, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27908979/secondhand-smoke-exposure-and-risk-of-lung-cancer-in-japan-a-systematic-review-and-meta-analysis-of-epidemiologic-studies
#2
Satoru Shikata, Yousuke Takemura
No abstract text is available yet for this article.
December 1, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27889695/retrospective-observational-study-of-occult-cervical-lymph-node-metastasis-in-t1n0-tongue-cancer
#3
Takayuki Imai, Ikuro Satoh, Ko Matsumoto, Yukinori Asada, Tomoko Yamazaki, Shinkichi Morita, Satoshi Saijo, Jun-Ichi Okubo, Shun Wakamori, Shigeru Saijo, Kazuto Matsuura
OBJECTIVE: Delayed neck metastasis is the most significant prognostic factor for early tongue cancer. The main strategies for controlling cervical lymph nodes in Japan are elective neck dissection or watchful waiting. Elective neck dissection offers significantly better survival, but adversely impacts patient quality of life; consequently, here we investigated how to identify high-risk patients warranting elective neck dissection. METHODS: We retrospectively evaluated 67 patients with T1N0 oral tongue squamous cell carcinoma who underwent primary treatment in our department from April 2001 to March 2015...
November 25, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27889694/extensive-peritoneal-lavage-after-curative-gastrectomy-for-gastric-cancer-expel-study-protocol-of-an-international-multicentre-randomised-controlled-trial
#4
Guowei Kim, Elya Chen, Amy Yl Tay, Jin San Lee, Janelle Ns Phua, Asim Shabbir, Jimmy By So, Bee Choo Tai
Peritoneal recurrence after gastrectomy for gastric cancer is common and the prognosis is dismal. Recent evidence suggests that extensive peritoneal lavage with large volume of normal saline after surgery before abdominal closure can reduce the risk of peritoneal recurrence and improve overall survival. This study aims to evaluate the benefit of extensive intraoperative peritoneal lavage. This is a prospective, open-label, multicentre randomised controlled trial involving 15 international centres in China, Korea, Japan, Malaysia and Singapore...
November 25, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27799281/classification-of-adult-diffuse-gliomas-by-molecular-markers-a-short-review-with-historical-footnote
#5
REVIEW
Ryohei Otani, Takeo Uzuka, Keisuke Ueki
Classification of gliomas, first established by Cushing and Bailey in early 20th century, has been based on histological features that were associated with clinical behavior of the tumor fairly well. However, inter-observer variation in the diagnosis and heterogeneous clinical outcome within a single entity have been problematic in some cases. Accumulation of molecular information of gliomas over the past two to three decades gradually elucidated the mechanism of oncogenesis and progression of gliomas at the molecular level, and it now appears to be possible to classify gliomas by the molecular markers, especially in adult diffuse gliomas that constitute ~25-30% of the primary intracranial tumors...
October 31, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27784752/preoperative-predictors-of-distant-recurrence-in-patients-with-clinical-stage-ia-lung-adenocarcinoma-undergoing-complete-resection
#6
Yuta Ibuki, Yasuhiro Tsutani, Yoshihiro Miyata, Haruhiko Nakayama, Sakae Okumura, Masahiro Yoshimura, Morihito Okada
OBJECTIVE: We aimed to identify patients with clinical Stage IA lung adenocarcinoma who are at high risk for distant recurrence to preoperatively organize treatment strategies. METHODS: We analyzed correlations between preoperative clinical factors and the incidence of distant recurrence in 609 patients with clinical Stage IA lung adenocarcinoma that had been completely resected at four institutions. We excluded 24 patients with only locoregional recurrence and analyzed data from 585 patients...
October 26, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777268/immunoglobulin-g4-related-disease-presenting-as-an-intrapericardial-tumor
#7
Masanori Okada, Seiichiro Sugimoto, Masaomi Yamane, Shinichiro Miyoshi
No abstract text is available yet for this article.
October 24, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777267/incidence-rate-for-prostate-cancer-in-japanese-in-japan-and-in-the-united-states-from-the-cancer-incidence-in-five-continents
#8
Kumiko Saika, Ryoko Machii
No abstract text is available yet for this article.
October 24, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27765814/collaboration-between-eortc-and-jcog-how-to-accelerate-global-clinical-research-partnership
#9
Kozo Kataoka, Kenichi Nakamura, Carmela Caballero, Serge Evrard, Anastassia Negrouk, Manabu Shiozawa, Laurence Collette, Haruhiko Fukuda, Denis Lacombe
The demand for international collaboration in cancer clinical trials has grown stronger to maximize efficiency, avoid duplication of effort and to achieve effective implementation of research results into medical practice. Infrastructures that could facilitate intercontinental collaboration not only between Europe and United States  but also between Europe and Asia are urgently needed. The European Organisation for Research and Treatment of Cancer, one of the major cancer clinical research infrastructure in Europe, initiated collaboration with the Japan Clinical Oncology Group, the largest cancer research cooperative group in Japan...
October 20, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27765813/limited-resection-for-early-stage-non-small-cell-lung-cancer-as-function-preserving-radical-surgery-a-review
#10
Keiju Aokage, Junji Yoshida, Tomoyuki Hishida, Masahiro Tsuboi, Hisashi Saji, Morihito Okada, Kenji Suzuki, Syunichi Watanabe, Hisao Asamura
Since 'radical lobectomy' was reported by Cahan in 1960, the standard surgical care for lung cancer has been lobectomy, in which units of the lobe are excised with their specific regional hilar and mediastinal lymphatics. However, pulmonary function-preserving limited resection for lung cancer has gradually become more prevalent in the late 20th century. In 1995, Ginsberg et al. conducted a randomized controlled trial in which limited resection (segmentectomy and wide-wedge resection) and lobectomy for stage I lung cancer were compared and reported that limited resection should not be applied to healthy patients with clinical stage IA lung cancer...
October 20, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27744326/is-cancer-history-really-an-exclusion-criterion-for-clinical-trial-of-lung-cancer-influence-of-gastrointestinal-tract-cancer-history-on-the-outcomes-of-lung-cancer-surgery
#11
Keiju Aokage, Morihito Okada, Kenji Suzuki, Shogo Nomura, Shigeki Suzuki, Norifumi Tsubokawa, Takahiro Mimae, Aritoshi Hattori, Tomoyuki Hishida, Junji Yoshida, Masahiro Tsuboi
OBJECTIVE: Exclusion of patients with a history of other cancer treatment except in situ situation has been considered to be inevitable for clinical trials investigating survival outcome. However, there have been few reports confirming these influences on surgical outcome of lung cancer patients ever. METHODS: Multi-institutional, individual data from patients with non-small cell lung cancer resected between 2000 and 2013 were collected. The patients were divided into two groups: those with a history of gastrointestinal tract cancer (GI group) and those without any history (non-GI group)...
October 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27744325/evaluation-of-predictors-of-unfavorable-pathological-features-in-men-eligible-for-active-surveillance-using-radical-prostatectomy-specimens-a-multi-institutional-study
#12
Kei Mizuno, Takahiro Inoue, Hidefumi Kinoshita, Toshifumi Yano, Hiroaki Kawanishi, Hideki Kanda, Naoki Terada, Takashi Kobayashi, Tomomi Kamba, Yoshiki Mikami, Taizo Shiraishi, Yoshiko Uemura, Yukihiro Imai, Gen Honjo, Tomoyuki Shirase, Kazuhiro Okumura, Mutsushi Kawakita, Keiji Ogura, Yoshiki Sugimura, Tadashi Matsuda, Osamu Ogawa
OBJECTIVE: Active surveillance has emerged as an alternative to immediate treatment in men with favorable-risk prostate cancer; however, consensus about defining the appropriate candidates is still lacking. To examine the factors predicting unfavorable pathology among active surveillance candidates, we assessed low-risk radical prostatectomy specimens. METHODS: This retrospective study included 1753 men who had undergone radical prostatectomy at six independent institutions in Japan from 2005 to 2011...
October 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27737964/regional-colorectal-cancer-screening-program-using-colonoscopy-on-an-island-a-prospective-nii-jima-study
#13
Kinichi Hotta, Takahisa Matsuda, Yasuo Kakugawa, Hiroaki Ikematsu, Nozomu Kobayashi, Ryoji Kushima, Atsushi Hozawa, Takeshi Nakajima, Taku Sakamoto, Mika Mori, Takahiro Fujii, Yutaka Saito
OBJECTIVE: Colorectal cancer screening program using fecal immunochemical test had been conducted on an isolated island named Nii-jima. However, the participation rate of the program had been approximately 12%, which was lower than average level of Japan. This study aimed to evaluate the participation rate, safety and efficacy of a colorectal cancer screening program using colonoscopy on the island. METHODS: Educational campaigns were actively conducted every month using information bulletins and special propaganda pamphlets...
October 13, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27737963/long-term-single-institute-experience-with-trimodal-bladder-preserving-therapy-with-proton-beam-therapy-for-muscle-invasive-bladder-cancer
#14
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
October 13, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27737962/correlations-of-insulin-like-growth-factor-i-and-insulin-like-growth-factor-i-receptor-with-the-clinicopathological-features-and-prognosis-of-patients-with-colon-cancer
#15
Lu Han, Guo-Feng Zhang, Yue-Hu Cheng, Qi-Cheng Zhao
OBJECTIVE: This study is designed to evaluate the correlations of insulin-like growth factor I (IGF-I) and insulin-like growth factor I receptor (IGF-IR) expressions with the clinicopathological features and prognosis of patients with colon cancer. METHODS: From January 2010 to January 2009, tissue samples were collected from 121 colon cancer patients, 147 with colon adenoma and 63 patients with chronic diarrhea. Real-time quantitative polymerase chain reaction was used to analyze the mRNA expressions of IGF-I and IGF-IR...
October 13, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27733509/postoperative-early-ultrasensitive-prostate-specific-antigen-identifies-patients-at-risk-for-biochemical-recurrence-in-margin-positive-prostate-cancers-a-single-center-study
#16
Koji Hatano, Takuya Okusa, Yu Ishizuya, Yasutomo Nakai, Masashi Nakayama, Ken-Ichi Kakimoto, Kazuo Nishimura
OBJECTIVE: To identify predictors for biochemical recurrence among patients with positive surgical margins (RM1) after radical prostatectomy and to examine the effect of ultrasensitive prostate-specific antigen measured early after prostatectomy on biochemical recurrence. METHODS: We identified 705 patients with prostate cancer who were treated with radical prostatectomy without preoperative hormonal therapy at our institution between 2000 and 2014. The patients with RM1 who had a postoperative prostate-specific antigen <0...
October 12, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27803033/a-single-arm-study-evaluating-bevacizumab-cisplatin-and-paclitaxel-followed-by-single-agent-bevacizumab-in-japanese-patients-with-advanced-cervical-cancer
#17
Toru Sugiyama, Mika Mizuno, Yoichi Aoki, Manabu Sakurai, Tadaaki Nishikawa, Eisuke Ueda, Kosei Tajima, Nobuhiro Takeshima
BACKGROUND: Adding bevacizumab to chemotherapy for recurrent, persistent or metastatic cervical cancer significantly improved overall survival (primary endpoint), progression-free survival and overall response rate in the randomized Phase III GOG-0240 trial. However, data for bevacizumab-containing therapy are scarce in Japanese patients with advanced cervical cancer. METHODS: The primary objective of the single-arm multicenter Phase II JO29569 study was to evaluate the tolerability of paclitaxel (135 mg/m(2) over 24 h or 175 mg/m(2) over 3 h), cisplatin (50 mg/m(2)) and bevacizumab (15 mg/kg), administered every 3 weeks until disease progression or unacceptable toxicity in Japanese patients with stage IVB, persistent or recurrent cervical cancer...
October 7, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27702837/role-of-multimodality-therapy-in-ciiia-n2-non-small-cell-lung-cancer-perspective
#18
Hidehito Horinouchi
A number of promising new approaches for both local and systemic control of locally advanced non-small cell lung cancer have been examined in clinical trials, aimed at improving the patient survival. Development of better systemic therapies by adopting newer agents (such as epidermal growth factor receptor-tyrosine kinase inhibitors and immune checkpoint inhibitors) from advanced non-small cell lung cancer is mandatory. As for radiotherapy, adaptive radiotherapy and proton therapy are under investigation after the RTOG 0617 trial unexpectedly failed to show the efficacy of high-dose radiotherapy for Stage III disease...
October 4, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27702836/the-predictive-value-of-18f-fdg-pet-for-pathological-response-of-primary-tumor-in-patients-with-esophageal-cancer-during-or-after-neoadjuvant-chemoradiotherapy-a-meta-analysis
#19
Lihong Cong, Shikun Wang, Teng Gao, Likuan Hu
OBJECTIVE: We want to review the value of 18-fluoro-deoxy-glucose positron emission tomography for response prediction of primary tumor in patients with esophageal cancer during or after neoadjuvant chemoradiotherapy. METHODS: Studies were searched in Pubmed, Embase and Cochrane Library with specific search strategy. The published articles were included according to the criteria established in advance. The included studies were divided into two groups according to the time of the repeat positron emission tomography: during (Group A) or after neoadjuvant chemoradiotherapy (Group B)...
October 4, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27677664/adjuvant-therapy-after-radical-surgery-for-stage-ib-iib-cervical-adenocarcinoma-with-risk-factors
#20
Toshiyuki Seki, Hiroshi Tanabe, Chie Nagata, Jiro Suzuki, Kayo Suzuki, Hirokuni Takano, Seiji Isonishi, Kazuhiko Ochiai, Satoshi Takakura, Aikou Okamoto
OBJECTIVE: Patients with adeno/adenosquamous carcinoma may have a poorer prognosis than patients with squamous cell carcinoma. Radiotherapy and concurrent chemoradiotherapy are used as adjuvant therapies for cervical cancer, regardless of the histological subtype. The aim of this study was to investigate the prognostic outcome of adjuvant therapy for patients with adeno/adenosquamous carcinoma with pathological risk factors. METHODS: The medical records of 135 patients with stage IB-IIB cervical cancer with squamous cell carcinoma or adeno/adenosquamous carcinoma who underwent primary surgery followed by adjuvant therapy were retrospectively reviewed...
September 27, 2016: Japanese Journal of Clinical Oncology
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