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Japanese Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/28073946/a-randomized-phase-iii-trial-of-comparing-two-dose-fractionations-stereotactic-body-radiotherapy-sbrt-for-medically-inoperable-stage-ia-non-small-cell-lung-cancer-or-small-lung-lesions-clinically-diagnosed-as-primary-lung-cancer-japan-clinical-oncology-group
#1
EDITORIAL
Tomoki Kimura, Yasushi Nagata, Junko Eba, Shuichi Ozawa, Satoshi Ishikura, Taro Shibata, Yoshinori Ito, Masahiro Hiraoka, Yasumasa Nishimura
A randomized Phase III trial commenced in Japan in February 2016. Currently, 42 Gy in four fractions of stereotactic body radiotherapy prescribed at the D95% of the planning target volume, which is considered equal to the commonly used 48 Gy in four fractions at the isocenter using an old dose calculation algorithm, is the standard treatment in Japan for medically inoperable Stage IA non-small cell lung cancer and small lung lesions clinically diagnosed as primary lung cancer. This study aims to examine the superiority of 55 Gy in four fractions over 42 Gy in four fractions...
January 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28073945/surgery-and-imatinib-therapy-for-liver-oligometastasis-of-gist-a-study-of-japanese-study-group-on-gist
#2
Tatsuo Kanda, Toru Masuzawa, Toshihiro Hirai, Osamu Ikawa, Akinori Takagane, Yasuhiro Hata, Hitoshi Ojima, Harutsugu Sodeyama, Izumi Mochizuki, Takashi Ishikawa, Tatsuo Kagimura, Toshirou Nishida
We conducted a multicenter prospective study to clarify the efficacy and safety of surgery and imatinib for liver oligometastasis of gastrointestinal stromal tumors. Eligible gastrointestinal stromal tumor patients were enrolled in the surgery trial or the imatinib trial. Primary endpoints were recurrence-free survival and progression-free survival, respectively. The trials were prematurely terminated due to amendment of guidelines for adjuvant imatinib therapy and low patient accrual. In the surgery trial, all the six patients showed hepatic recurrence: median recurrence-free survival was 145 days (range: 62-1366 days)...
January 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064206/retrospective-analysis-of-survival-in-patients-with-leptomeningeal-carcinomatosis-from-lung-adenocarcinoma-treated-with-erlotinib-and-gefitinib
#3
Jumpei Kashima, Yusuke Okuma, Maki Miwa, Yukio Hosomi
BACKGROUND: Leptomeningeal carcinomatosis is a relatively rare metastatic form of non-small cell lung cancer, which can impact prognosis. There is an increasing need for selecting suitable epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors among those currently included in standard care for EGFR mutation-positive patients. We compared the efficacy of gefitinib and erlotinib in survival of patients with leptomeningeal carcinomatosis. PATIENTS AND METHODS: The medical records of 269 patients who received tyrosine kinase inhibitors at a single center were retrospectively reviewed...
January 6, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064205/incidence-rate-for-gallbladder-cancer-in-japanese-in-japan-and-in-the-united-states-from-the-cancer-incidence-in-five-continents
#4
Kota Katanoda, Megumi Hori
No abstract text is available yet for this article.
January 6, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064204/a-histological-positive-margin-after-surgery-is-correlated-with-high-local-re-recurrence-rate-in-patients-with-recurrent-myxofibrosarcoma
#5
Kazutaka Kikuta, Robert Nakayama, Akihiko Yoshida, Aya Sasaki, Kaori Kameyama, Hirokazu Chuman, Akira Kawai, Masaya Nakamura, Morio Matsumoto, Hideo Morioka
OBJECTIVE: Myxofibrosarcoma has high frequency of local recurrence after surgery. To determine an optimal treatment for recurrent tumors, clinical features of recurrent cases should be characterized. METHODS: We performed a retrospective analysis of 30 patients with recurrent myxofibrosarcoma who underwent surgery between 1999 and 2008. RESULTS: A negative margin after surgery was achieved in only 12 patients (40.0%). The 5-year re-recurrence free-survival rate was 31...
January 6, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064203/predictive-factors-of-gastroduodenal-bleeding-after-postoperative-radiotherapy-in-biliary-tract-cancer
#6
Jieun Lee, Do Hoon Lim, Hee Chul Park, Jeong Il Yu, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo
OBJECTIVE: To identify predictive factors for gastroduodenal bleeding after postoperative radiation therapy in patients with biliary tract cancer. METHODS: We identified 186 patients with biliary tract cancer who completed scheduled postoperative radiation therapy from March 2000 to August 2013. To isolate the effects of radiation on gastroduodenal bleeding, patients with pylorus-preserving pancreaticoduodenectomy, pylorus-resecting pancreaticoduodenectomy or Whipple surgery (n = 67) were excluded from this analysis...
January 6, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28042138/the-efficacy-and-safety-of-docetaxel-based-chemotherapy-combined-with-dexamethasone-1-mg-daily-oral-administration-jmto-pca-10-01-phase-ii-trial
#7
Nobumichi Tanaka, Kazuo Nishimura, Eijiro Okajima, Kenji Ina, Osamu Ogawa, Hirohiko Nagata, Koichiro Akakura, Kiyohide Fujimoto, Momokazu Gotoh, Satoshi Teramukai, Yoshihiko Hirao
OBJECTIVES: Previously, one randomized control trial (TAX327) revealed the efficacy of docetaxel-based chemotherapy combined with prednisone. On the other hand, several studies showed a high prostate specific antigen (PSA) response with low-dose dexamethasone in castration-resistant prostate cancer (CRPC) patients. The objective of this study was to evaluate the efficacy and safety of docetaxel-based chemotherapy combined with dexamethasone in CRPC patients. MATERIALS AND METHODS: This study was a single-arm multi-institutional phase II trial...
January 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28042137/immunogenicity-and-safety-of-human-papillomavirus-hpv-vaccination-in-asian-populations-from-six-countries-a-meta-analysis
#8
Didik Setiawan, Jos Luttjeboer, Koen B Pouwels, Jan C Wilschut, Maarten J Postma
Cervical cancer is a serious public-health problem in Asian countries. Since human papillomavirus (HPV) infection is the main risk factor for cervical cancer, HPV vaccination is considered a promising strategy to prevent cervical cancer. However, comprehensive immunogenicity and safety information for Asian populations is lacking. We searched four electronic databases including PubMed, EMBASE, Cochrane Library, and clinicaltrials.gov. We reviewed selected manuscripts and extracted the pooled relative risk (RR) from immunogenicity and safety information on HPV vaccination among women in Asian countries...
January 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28042136/epidemiology-and-treatment-of-hepatocellular-carcinoma-in-thailand
#9
REVIEW
Soonthorn Chonprasertsuk, Ratha-Korn Vilaichone
Hepatocellular carcinoma (HCC) is the most frequent type of malignant liver tumor in Thailand. The high incidence rate of HCC reflects from chronic HBV infection in this endemic area. Some patients are asymptomatic at presentation whereas many of them presented at advanced stage of HCC with limited treatment options and grave outcome. The Barcelona Clinic Liver Cancer (BCLC) staging system and management allocation for HCC is widely accepted and used in many international guidelines including Thailand. Curative treatment is expected in early stage of HCC while palliative treatment, combination treatment and best supportive care are offered to advanced stage of HCC...
January 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28031357/prevalence-of-lynch-syndrome-and-lynch-like-syndrome-among-patients-with-colorectal-cancer-in-a-japanese-hospital-based-population
#10
Noriyasu Chika, Hidetaka Eguchi, Kensuke Kumamoto, Okihide Suzuki, Keiichiro Ishibashi, Tetsuhiko Tachikawa, Kiwamu Akagi, Jun-Ichi Tamaru, Yasushi Okazaki, Hideyuki Ishida
No abstract text is available yet for this article.
December 27, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28031356/elective-nodal-irradiation-is-not-necessary-in-chemoradiotherapy-for-postoperative-loco-regional-recurrent-esophageal-cancer
#11
Keiichi Jingu, Rei Umezawa, Takaya Yamamoto, Haruo Matsushita, Youjirou Ishikawa, Maiko Kozumi, Masaki Kubozono, Noriyoshi Takahashi, Noriyuki Kadoya, Ken Takeda
PURPOSE: The purposes of the present study were to evaluate prognostic factors for patients with postoperative loco-regional recurrent esophageal cancer treated with chemoradiotherapy by multivariate analysis and to determine which irradiation is better, involved field irradiation or elective nodal irradiation, by matched-pair analysis. METHODS: We reviewed records for 80 patients with postoperative loco-regional recurrent esophageal cancer treated by chemoradiotherapy between 2000 and 2014...
December 27, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28031355/evaluation-of-tumor-burden-after-sequential-molecular-targeted-therapy-in-patients-with-metastatic-renal-cell-carcinoma
#12
Hiroki Ishihara, Tsunenori Kondo, Kazuhiko Yoshida, Kenji Omae, Toshio Takagi, Junpei Iizuka, Hirohito Kobayashi, Kazunari Tanabe
BACKGROUND: To evaluate the effect of tumor burden on survival in patients with metastatic renal cell carcinoma who are administered sequential molecular-targeted therapy. METHODS: A total of 68 patients were recruited. Baseline tumor burden at the time of second-line therapy initiation was calculated according to the Response Evaluation Criteria in Solid Tumors v. 1.1. Patients were divided into two subgroups according to the median tumor burden: greater than the median as the high group, lower than the median as the low group...
December 27, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28003321/collaborative-care-intervention-for-the-perceived-care-needs-of-women-with-breast-cancer-undergoing-adjuvant-therapy-after-surgery-a-feasibility-study
#13
Kanae Momino, Miyashita Mitsunori, Hiroko Yamashita, Tatsuya Toyama, Hiroshi Sugiura, Nobuyasu Yoshimoto, Kei Hirai, Tatsuo Akechi
OBJECTIVE: This study aimed to investigate the feasibility of an intervention program for women with breast cancer undergoing adjuvant anticancer therapy, and determine its preliminary effectiveness in reducing their unmet needs and psychological distress. METHODS: The intervention was based on the collaborative care model, and compromised four domains: identification of unmet needs, problem-solving therapy and behavioral activation supervised by a psychiatrist, psychoeducation and referral to relevant departments...
December 20, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28003320/post-hoc-analysis-of-japanese-patients-from-the-placebo-controlled-prevail-trial-of-enzalutamide-in-patients-with-chemotherapy-naive-metastatic-castration-resistant-prostate-cancer-updated-results
#14
Go Kimura, Takeshi Ueda
A post hoc analysis of interim results from PREVAIL, a Phase III, double-blind, placebo-controlled trial of men with metastatic castration-resistant prostate cancer, demonstrated that the treatment effects, safety and pharmacokinetics of enzalutamide in Japanese patients were generally consistent with those of the overall population. A recent longer term analysis of PREVAIL demonstrated continued benefit of enzalutamide treatment over placebo. Here, we report results from a post hoc analysis of Japanese patients enrolled in PREVAIL at the prespecified number of deaths for the final analysis...
December 20, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27989996/editorial
#15
EDITORIAL
Tadao Kakizoe
No abstract text is available yet for this article.
December 17, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27980085/the-feasibility-and-effectiveness-of-robot-assisted-radical-cystectomy-after-neoadjuvant-chemotherapy-in-patients-with-muscle-invasive-bladder-cancer
#16
Takuya Koie, Chikara Ohyama, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa, Atsushi Yamauchi, Toru Shimazui, Mikinobu Ohtani
OBJECTIVES: The aim of this study was to compare 29 muscle-invasive bladder cancer patients who received neoadjuvant chemotherapy (NAC) followed by immediate robot-assisted radical cystectomy (RARC) with those who underwent minimum-incision endoscopic RC (MIE-RC). METHODS: We retrospectively reviewed the charts of 430 consecutive patients who underwent RC and bilateral pelvic node dissection (PLND) between May 1994 and July 2016. Our study focused on patients with MIBC who had histologically confirmed stage T2-T4aN0M0 urothelial carcinoma of the bladder and received NAC prior to surgery...
December 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27980084/utility-of-rapid-on-site-cytologic-evaluation-during-endobronchial-ultrasound-with-a-guide-sheath-for-peripheral-pulmonary-lesions
#17
Takehiro Izumo, Yuji Matsumoto, Shinji Sasada, Christine Chavez, Toshiyuki Nakai, Takaaki Tsuchida
OBJECTIVE: The utility of rapid on-site evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions is unclear. The aim of this study was to evaluate the role of rapid on-site evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions. METHODS: Consecutive patients who underwent endobronchial ultrasound with a guide sheath for the diagnosis of peripheral pulmonary lesions at our hospital between September 2012 and July 2014 were included in this retrospective study...
December 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27980083/is-cancer-history-really-an-exclusion-criterion-for-clinical-trial-of-lung-cancer-influence-of-gastrointestinal-tract-cancer-history-on-the-outcomes-of-lung-cancer-surgery
#18
Keiju Aokage, Morihito Okada, Kenji Suzuki, Shogo Nomura, Shigeki Suzuki, Norifumi Tsubokawa, Takahiro Mimae, Aritoshi Hattori, Tomoyuki Hishida, Junji Yoshida, Masahiro Tsuboi
No abstract text is available yet for this article.
December 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27980082/a-review-of-prognostic-scores-after-liver-resection-in-hepatocellular-carcinoma-the-mskcc-slicer-and-ssclip-scores
#19
REVIEW
Esther Ern-Hwei Chan, Pierce Kah-Hoe Chow
Predicting prognosis in hepatocellular carcinoma (HCC) aids clinical decision-making and stratifies patient follow-up plans. There are currently three prognostic scores specific to liver resection of HCC published in the literature: the MSKCC, SLICER and SSCLIP scores. In this review, we highlight the methodology employed in the construction of these scores and discuss the strengths and weaknesses of each. Current limitations to prognostic scores include the inability to differentiate between early and late recurrences of HCC, the failure to account for the impact of aetiology of HCC and the assumption that ethnicity has no impact on disease process...
December 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27940489/predictive-factors-of-late-biochemical-recurrence-after-radical-prostatectomy
#20
Takahito Negishi, Kentarou Kuroiwa, Yoshifumi Hori, Toshihisa Tomoda, Hiroshi Uchino, Noriaki Tokuda, Nobuki Furubayashi, Kei Nagase, Hidenori Iwai, Motonobu Nakamura
OBJECTIVE: To assess the characteristics of biochemical recurrence in the late period (>5 years after radical prostatectomy) and the differences in the predictors of biochemical recurrence in different periods, we conducted a multicenter retrospective study. METHODS: We reviewed 478 men who underwent radical prostatectomy for clinically localized prostate cancer. All of the patients were followed up for at least 5 years. The cohort was then divided into three groups; no recurrence group, recurrence <5 years after surgery group and recurrence ≥5 years after surgery group...
December 8, 2016: Japanese Journal of Clinical Oncology
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