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Veterinary Pathology

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https://www.readbyqxmd.com/read/29635994/multifaceted-roles-of-autophagy-in-health-and-disease
#1
Joshua D Webster
No abstract text is available yet for this article.
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29635993/promoting-global-health-through-pathology-initiation-of-the-global-health-pathology-network
#2
Corrie C Brown, Derron A Alves, Sarah M Corner, Tanja S Zabka
No abstract text is available yet for this article.
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29635992/erratum
#3
(no author information available yet)
Pasolini MP, Pagano TB, Costagliola A, et al. Inflammatory Myopathy in Horses With Chronic Piroplasmosis. Vet Path. 2017; 55(1):133-143. (Original DOI: 10.1177/0300985817716262) In volume 55, issue 1, page 133, the tenth author Vincenzo Veneziano was incorrectly listed as Veneziano Veneziano. This has been corrected online.
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29433400/roles-for-autophagy-proteins-in-immunity-and-host-defense
#4
Rachel L Kinsella, Eric M Nehls, Christina L Stallings
There is a clear link between defects in autophagy and the development of autoimmune and chronic inflammatory diseases, raising interest in better understanding the roles of autophagy within the immune system. In addition, autophagy has been implicated in the immune response to infection by pathogenic microbes. As such, there are efforts currently underway to develop modulators of autophagy as a therapeutic strategy for the treatment of the autoimmune, inflammatory, and infectious diseases. In this review, we discuss the numerous roles for autophagy in immunity and how these activities are linked to disease...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29421972/canine-bocavirus-type-2-infection-associated-with-intestinal-lesions
#5
Chutchai Piewbang, Wendy K Jo, Christina Puff, Martin Ludlow, Erhard van der Vries, Wijit Banlunara, Anudep Rungsipipat, Jochen Kruppa, Klaus Jung, Somporn Techangamsuwan, Wolfgang Baumgärtner, Albert D M E Osterhaus
Bocaviruses are small nonenveloped DNA viruses belonging to the Bocaparvovirus genus of the Parvoviridae family and have been linked to both respiratory and enteric disease in humans and animals. To date, 3 bocaviruses, canine bocaviruses 1 to 3 (CBoV-1-3), have been shown to affect dogs with different disease manifestations reported for infected animals. We used next-generation sequencing to identify a novel strain of canine CBoV-2 (CBoV TH-2016) in a litter of puppies that died in Thailand from acute dyspnea and hemoptysis, for which no causal pathogen could be identified in routine assays...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29402208/border-disease-virus-infection-of-bovine-placentas
#6
Miguel Fernández, Ueli Braun, Sandra Frei, Matthias Schweizer, Monika Hilbe
Subsequent to a previous study of border disease virus (BDV) horizontal transmission from a persistently BDV-infected calf to 6 seronegative pregnant heifers, the heifers were slaughtered 60 days after exposure to the infected calf, and their fetuses and placentas were examined. Immunohistochemical examination of fetal organs and placenta showed positive labeling of moderate intensity for pestivirus antigen in 3 of 6 heifers. BDV infection in these 3 animals was confirmed by the detection of BDV RNA in different organs using reverse transcription quantitative polymerase chain reaction...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29402207/congenital-hepatic-fibrosis-in-a-purebred-spanish-horse-foal-pathology-and-genetic-studies-on-pkhd1-gene-mutations
#7
Jéssica Molín, Javier Asín, Arantzazu Vitoria, Arianne Sanz, Marina Gimeno, Antonio Romero, Javier Sánchez, Pedro Pinczowski, Francisco J Vázquez, Clementina Rodellar, Lluís Luján
A 1-month-old Purebred Spanish Horse (PSH) foal presented with progressive hepatic failure culminating in death. Hepatic lesions were consistent with congenital hepatic fibrosis (CHF). Genetic studies in the PKHD1 gene in the affected foal revealed that it was heterozygous for the 2 previously described single-nucleotide polymorphisms (SNPs) linked to CHF in Swiss Franches-Montagnes (SFM) horses. In addition, 2 novel mutations were detected, the foal being homozygous for one of them and heterozygous for the other...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29402205/prostatic-lesions-in-odontocete-cetaceans
#8
Cristian M Suárez-Santana, Eva Sierra, Josue Díaz-Delgado, Daniele Zucca, Yara Bernaldo de Quirós, Raquel Puig-Lozano, Nakita Câmara, Jesús De la Fuente, Antonio Espinosa de Los Monteros, Miguel Rivero, Manuel Arbelo, Antonio Fernández
The prostate is the only accessory male genital gland described in cetaceans. Although few studies describe the gross and histologic anatomy of the prostate in cetaceans, there is no information on pathological findings involving this organ. The prostate glands of 45 cetaceans, including 8 different odontocete species ( n = 44) and 1 mysticete, were evaluated. The main pathologic diagnoses were verminous prostatitis, septic prostatitis, viral prostatitis, benign prostatic hyperplasia, and prostatitis of unknown etiology...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29402204/glomeruloid-microvascular-proliferation-desmoplasia-and-high-proliferative-index-as-potential-indicators-of-high-grade-canine-choroid-plexus-tumors
#9
Luisa Vera Muscatello, Giancarlo Avallone, Fabienne Serra, Torsten Seuberlich, Maria Teresa Mandara, Silvia Sisó, Barbara Brunetti, Anna Oevermann
Choroid plexus tumors (CPT) are intraventricular neoplasms accounting for 10% of all primary central nervous system tumors in dogs. They are frequently classified according to the human WHO classification into choroid plexus papilloma (CPP, grade I), atypical CPP (aCPP, grade II), and choroid plexus carcinoma (CPC, grade III). Histological features observed in canine CPT such as increased vascular density (IVD) and glomeruloid microvascular proliferation (GMVP) are not part of the WHO classification. This multi-centric study aimed to investigate tumor-associated vascular hyperplasia in dogs by determining the prevalence of GMVP and IVD in 52 canine CPT and their association with tumor grade...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29310550/a-review-on-chlamydial-diseases-in-animals-still-a-challenge-for-pathologists
#10
Nicole Borel, Adam Polkinghorne, Andreas Pospischil
Chlamydiae have a worldwide distribution causing a wide range of diseases in human hosts, livestock, and companion animals as well as in wildlife and exotic species. Moreover, they can persist in their hosts as asymptomatic infections for extended periods of time. The introduction of molecular techniques has revolutionized the Chlamydia field by expanding the host range of known chlamydial species but also by discovering new species and even new families of bacteria in the broader order Chlamydiales. The wide range of hosts, diseases, and tissues affected by chlamydiae complicate the diagnosis such that standard diagnostic approaches for these bacteria are rare...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29310549/congenital-short-bowel-syndrome-in-an-adult-dog
#11
Chad S Clancy, Khrista A Jensen, Arnaud J Van Wettere
A 3.5-year-old, neutered male pit bull dog was euthanized following an approximately 1-year history of intractable diarrhea and weight loss of undetermined cause. At necropsy, the dog was emaciated. The ratio of total intestinal length (duodenum to rectum) to crown-to-rump length was 2.5, in contrast to an average of 5.3 (range, 3.7-6.1) in 10 control dogs examined at necropsy. There was diffuse dilation of the intestinal lumen, consistent with congenital intestinal hypoplasia resulting in short-bowel syndrome...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29457567/time-to-standardize-time-to-validate
#12
Don Meuten, John S Munday, Marlene Hauck
No abstract text is available yet for this article.
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29457566/using-genetically-modified-rodent-models-in-drug-development-to-explore-target-physiology-and-potential-drug-effects
#13
Yu Zhong, Donna M Dambach, Jonathan M Maher
No abstract text is available yet for this article.
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29457565/current-status-and-future-perspectives-in-canine-oral-squamous-cell-carcinoma
#14
Lisa A Mestrinho
No abstract text is available yet for this article.
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29338616/systemic-loss-of-c-terminal-src-kinase-expression-elicits-spontaneous-suppurative-inflammation-in-conditional-knockout-mice
#15
Lisa D Berman-Booty, Rukiye Eraslan, Umesh Hanumegowda, Glenn H Cantor, Denise I Bounous, Evan B Janovitz, Beverly K Jones, Olesia Buiakova, Michael Hayward, Susan Wee
C-terminal Src kinase (Csk) is one of the critical negative regulators of the Src family of kinases. The Src family of kinases are nonreceptor tyrosine kinases that regulate inflammation, cell proliferation, motility, and adhesion. To investigate potential histologic lesions associated with systemic loss of Csk gene activity in adult mice, conditional Csk-knockout mice were examined. Cre-mediated systemic excision of Csk induced by tamoxifen treatment resulted in multiorgan inflammation. Specifically, induction of Csk gene excision with three days of tamoxifen treatment resulted in greater than 90% gene excision...
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29338615/assessment-of-canine-mast-cell-tumor-mortality-risk-based-on-clinical-histologic-immunohistochemical-and-molecular-features
#16
Rodrigo S Horta, Gleidice E Lavalle, Lidianne N Monteiro, Mayara C C Souza, Geovanni D Cassali, Roberto B Araújo
Mast cell tumor (MCT) is a frequent cutaneous neoplasm in dogs that is heterogeneous in clinical presentation and biological behavior, with a variable potential for recurrence and metastasis. Accurate prediction of clinical outcomes has been challenging. The study objective was to develop a system for classification of canine MCT according to the mortality risk based on individual assessment of clinical, histologic, immunohistochemical, and molecular features. The study included 149 dogs with a histologic diagnosis of cutaneous or subcutaneous MCT...
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29310551/corrigendum
#17
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29284372/histologic-grade-does-not-predict-outcome-in-dogs-with-appendicular-osteosarcoma-receiving-the-standard-of-care
#18
Courtney R Schott, Laetitia J Tatiersky, Robert A Foster, Geoffrey A Wood
Canine appendicular osteosarcoma is an aggressive bone neoplasm that imposes a short survival time. There are several published histologic grading systems for canine osteosarcoma but no universally accepted system. Location within the skeleton and therapy received are both correlated with survival time, but these factors were not always considered when the prognostic value of published grading systems was determined. Our objective was to compare 2 published histologic grading systems in a population of dogs with appendicular osteosarcoma treated with the standard of care for curative intent...
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29262763/immunohistochemical-characterization-of-canine-oral-papillary-squamous-cell-carcinoma
#19
Tuddow Thaiwong, Dodd G Sledge, Alexandra Collins-Webb, Matti Kiupel
Recently, histologic subtypes of oral squamous cell carcinoma (SCC) corresponding to the human classification scheme have been proposed for dogs. A papillary squamous cell carcinoma subtype is characterized by dominant exophytic architectural growth with limited invasion, a lower metastatic rate, and better overall survival compared with conventional SCC. Whereas most canine oral conventional SCCs are easily diagnosed by histologic examination, the diagnosis of canine oral papillary squamous cell carcinoma (COPSCC) can be challenging since the exophytic portion lacks histologic features of malignancy and appears similar to oral nonviral papillomas...
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29258402/pathology-of-the-emerging-mycobacterium-tuberculosis-complex-pathogen-mycobacterium-mungi-in-the-banded-mongoose-mungos-mungo
#20
Kathleen A Alexander, Peter N Laver, Mark C Williams, Claire E Sanderson, Carly Kanipe, Mitchell V Palmer
Wild banded mongooses ( Mungos mungo) in northeastern Botswana and northwest Zimbabwe are infected with a novel Mycobacterium tuberculosis complex (MTC) pathogen, Mycobacterium mungi. We evaluated gross and histologic lesions in 62 infected mongooses (1999-2017). Many tissues contained multifocal irregular, lymphohistiocytic to granulomatous infiltrates and/or multifocal or coalescing noncaseating to caseating granulomas with variable numbers of intralesional acid-fast bacilli. Over one-third of nasal turbinates examined had submucosal lymphohistiocytic to granulomatous infiltrates, erosion and ulceration of the nasal mucosa, bony remodeling, and nasal distortion...
March 2018: Veterinary Pathology
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