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Clinical Allergy

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https://www.readbyqxmd.com/read/3436030/allergy-in-chronic-haemodialysis-1-double-blind-intravenous-challenge-with-formaldehyde
#1
J Bousquet, J P Rivory, F Maurice, W Skassa-Brociek, P Larrson, S G Johansson, P Florence, F B Michel
Patients undergoing chronic haemodialysis are often exposed to formaldehyde formaldehyde (F) has been reported to cause IgE-mediated anaphylactic shock. Many other patients reported pruritus or anaphylaxis-like symptoms when dialysed with F-sterilized dialysers. Ten patients presenting such symptoms were compared with five control subjects. Intravenous double-blind challenges were performed on six consecutive occasions, with capillary flow dialysers sterilized with or without F. Dialysis was performed by an investigator who was not aware of the sterilization procedure...
November 1987: Clinical Allergy
https://www.readbyqxmd.com/read/3087656/oral-antihistamine-or-nasal-steroid-in-hay-fever-a-double-blind-double-dummy-comparative-study-of-once-daily-oral-astemizole-vs-twice-daily-nasal-beclomethasone-dipropionate
#2
RANDOMIZED CONTROLLED TRIAL
S F Wood
Seventy-four patients with a well documented history of seasonal allergic rhinitis were randomly allocated to receive either astemizole 10 mg orally per day or beclomethasone 100 micrograms in each nostril twice daily on a double-blind double-dummy basis. The patients were studied in a general practice setting and were seen at entry, during the study and at the end of the study by a single observer, the author. Assessment was by diary card incorporating five 10 cm visual analogue scales related to the four symptoms of sneezing, rhinorrhoea, blocked nose and itchy eyes and an overall assessment of hay fever symptoms...
May 1986: Clinical Allergy
https://www.readbyqxmd.com/read/3955800/skin-reactivity-and-specific-ige-levels-in-the-evaluation-of-allergic-sensitivity-to-common-allergens-for-epidemiological-purposes
#3
COMPARATIVE STUDY
P L Paggiaro, E Bacci, D L Amram, O Rossi, D Talini
An investigation was conducted to test the validity of the skin-prick test (SPT) with eleven common allergens (Lofarma series proposed by Italian National Research Council for epidemiological studies) as a method for predicting the presence of specific antibodies in serum. The relationship between SPT, evaluated by two different methods (MWD = mean weal diameter, AHWR = allergen histamine weal ratio), and specific IgE levels (RAST) has been investigated in 101 patients tested consecutively for suspected allergic disease...
January 1986: Clinical Allergy
https://www.readbyqxmd.com/read/3955799/use-of-liquid-nitrogen-in-the-control-of-house-dust-mite-populations
#4
COMPARATIVE STUDY
M J Colloff
Laboratory and field studies on the use of liquid nitrogen as an acaricide, combined with vacuum cleaning, demonstrated this inert freezing agent to be extremely efficient in reducing the number of live mites in mattresses when compared to vacuum cleaning only. Preliminary observations suggest this treatment does no physical damage to mattresses. Any strategy in the control of house dust mites should incorporate procedures both for the reduction of the mite population and the removal of the allergen pool of faecal pellets and dead mites...
January 1986: Clinical Allergy
https://www.readbyqxmd.com/read/3955798/pneumococcus-specific-immunoglobulin-e-in-cigarette-smokers
#5
COMPARATIVE STUDY
J W Bloom, M Halonen, A M Dunn, J L Pinnas, B Burrows
A relationship between elevated serum immunoglobulin E levels and smoking has been demonstrated in epidemiological studies. Allergy skin test data suggest that the excess immunoglobulin E of smokers is not specific for aeroallergens. It is possible that the excess immunoglobulin E is specific for microorganisms that often infect the lower respiratory tract of smokers. To investigate this possibility we utilized a radioallergosorbent test assay for detecting serum immunoglobulin E specific for Streptococcus pneumoniae, an organism commonly isolated from the respiratory tract of smokers with chronic bronchitis...
January 1986: Clinical Allergy
https://www.readbyqxmd.com/read/4075516/gastrointestinal-permeability-in-atopic-and-non-atopic-mothers-assessed-with-different-sized-polyethyleneglycols-peg-400-and-peg-1000
#6
COMPARATIVE STUDY
K Fälth-Magnusson, N I Kjellman, T Sundqvist, K E Magnusson
Gastrointestinal permeability was compared in seventy-one women, forty-six allergic and twenty-five non-allergic according to case history, by measuring the 6-hr urinary recovery after an oral load of different-sized polyethyleneglycols (PEG 400 and PEG 1000). Further classification, atopic and non-atopic, was obtained by skin-prick tests to inhalant and food allergens in sixty-four of the seventy-one mothers. No significant differences were observed between allergic and non-allergic women, neither regarding the maximum recovery nor the recovery ratio between a large and a small molecule...
November 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4075515/storage-mite-allergy-is-common-in-a-farming-population
#7
M van Hage-Hamsten, S G Johansson, S Höglund, P Tüll, A Wirén, O Zetterstrom
The prevalence of storage mite allergy was investigated in an epidemiological study of respiratory symptoms in farmers on Gotland, an island in the Baltic Sea. A questionnaire concerning work-related and chronic symptoms from the airways and eyes was completed by 2578 farmers. A sample of 440 farmers subsequently underwent examination comprising skin-prick tests (animal danders, pollens, moulds and house dust mite), blood sampling for RAST against four storage mites (Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae and Glycyphagus domesticus) and total IgE analyses...
November 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4075514/predictive-value-of-cord-blood-ige-in-the-development-of-atopic-disease-and-role-of-breast-feeding-in-its-prevention
#8
R K Chandra, S Puri, P S Cheema
The predictive value of cord blood IgE in the development of atopic disease was evaluated in a prospective study of two groups of infants. Total serum IgE level was greater than or equal to 0.7 U/ml in 44.3% of the infants with positive family history of atopy and in 16.0% among those with negative family history. The level of cord blood IgE correlated significantly with the subsequent development of atopic disease in both groups. Cord blood IgE higher than 0.7 U/ml was associated with a high risk of development of atopic eczema and wheezing, 52...
November 1985: Clinical Allergy
https://www.readbyqxmd.com/read/3935343/effects-of-verapamil-and-sodium-cromoglycate-on-bronchoconstriction-induced-by-isocapnic-hyperventilation
#9
P Rafferty, R J Fergusson, P M Tweeddale, B A Biggs, I W Grant
Twenty-four patients who were known to develop bronchoconstriction in response to isocapnic hyperventilation (IH) took part in a double-blind, placebo-controlled trial to assess the effects of verapamil (5 mg) and sodium cromoglycate (SCG) 20 mg in the prevention of IH-induced bronchoconstriction. Both drug and placebo were inhaled in dry powder form and responses were assessed by serial measurements of forced expiratory volume in 1 sec (FEV1). Sodium cromoglycate was shown to offer significant protection whereas verapamil powder provoked bronchoconstriction in over 40% of patients and these patients appeared to be those with more marked degrees of bronchial reactivity...
November 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053338/effect-of-cigarette-smoking-on-the-antibody-response-to-inhaled-antigens-and-the-prevalence-of-extrinsic-allergic-alveolitis-among-pigeon-breeders
#10
COMPARATIVE STUDY
C McSharry, S W Banham, G Boyd
There was a reduced prevalence of symptoms of Extrinsic Allergic Alveolitis (EAA) among the cigarette smokers in a survey of 102 volunteer pigeon breeders. These smokers had a significantly lower antibody response against the inhaled antigens associated with the disease; only one of twenty-three smokers (4.3%), but thirty-nine of sixty-five non-smokers (55.4%) had elevated serum IgG antibody levels, despite similar degrees of avian exposure in each group. The appearance of antibody in six of fourteen ex-smokers (42...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053337/optimal-use-of-tube-spacer-aerosols-in-asthmatic-children
#11
S Pedersen
In a double blind cross-over study the bronchodilator response after eight different modes of inhalation of terbutaline from a pressurized aerosol with a tube spacer was assessed in fifteen asthmatic children. Slow inspiratory flow rates (15-30 l/min) were found to be associated with a statistically significant increase in response when compared with flow rates higher than 70 l/min (P less than 0.01). Tilting the head back during the inhalations and a breath-holding pause of 10 sec after the inhalation had no significant effect upon bronchodilation...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053336/effects-of-ketotifen-on-in-vitro-bronchoconstriction
#12
B G Loftus, J F Price, R Heaton, J F Costello
We have studied the effects of Ketotifen [Ke] (10(-4)M and 10(-6)M) on two in vitro models of bronchoconstriction: actively sensitized guinea-pig trachea (GPT), and passively sensitized human bronchial muscle (HBM). Experiments were performed on matched pairs of tissues. Cumulative dose response curves [CDRC] for histamine and acetyl choline were constructed, and repeated after pre-incubation with Ke or saline control. The effect of Ke on maximal antigen induced contractions was also studied. Contraction of GPT by histamine and acetyl choline was inhibited by Ke 10(-4)M, though this effect was not apparent at high doses of acetyl choline...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053335/reaginic-allergy-to-parthenium-pollen-evaluation-by-skin-test-and-rast
#13
COMPARATIVE STUDY
M Rao, O Prakash, P V Subba Rao
The pollen of Parthenium hysterophorus, an alien weed growing wild in India was found to be a potential source of allergic rhinitis. A clinical survey showed that 34% of the patients suffering from rhinitis and 12% suffering from bronchial asthma gave positive skin-prick test reactions to Parthenium pollen antigen extracts. Parthenium-specific IgE was detected in the sera of sixteen out of twenty-four patients suffering from seasonal rhinitis. There was 66% correlation between skin test and RAST.
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053334/allergy-in-the-mediterranean-area-iii-cross-reactivity-among-oleaceae-pollens
#14
COMPARATIVE STUDY
J Bousquet, B Guérin, B Hewitt, S Lim, F B Michel
Pollens of closely related species often share common antigens and allergens although this is not always the case. Four species of Oleaceae pollens commonly found in the Mediterranean area were investigated for cross-reactivity: olive (Olea europaea), ash (Fraxinus exselsior), privet (Ligustrum vulgare) and Phillyrea angustifolia, a common bush. Twenty individual sera of patients allergic to Oleaceae were investigated for specific IgE antibodies against the four species of Oleaceae pollens. The results indicated a high degree of correlation between RAST titres of Oleaceae pollens but three gave a particular emphasis on one species only...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053333/prevalence-and-features-of-asthma-in-a-sample-survey-of-urban-goroka-papua-new-guinea
#15
G K Dowse, D Smith, K J Turner, M P Alpers
This study found a prevalence of asthma of 2.5% in adults and 0.2% in children in Goroka, the major town and administrative centre of the Eastern Highlands Province of Papua New Guinea. The disease features are similar to those found in previous studies in Papua New Guinea: late age of onset and virtual absence of childhood cases; strong association with allergy to house dust mite and high mite-specific IgE levels; and considerable impairment of resting lung function. However, the prevalence is much lower than that recently found in the nearby rural South Fore linguistic group of the Okapa District...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4053332/eosinophils-bronchial-hyperreactivity-and-late-phase-asthmatic-reactions
#16
S R Durham, A B Kay
We have measured airways reactivity (methacholine PC20) and blood eosinophils in eleven asthmatics with allergen-induced late-phase reactions. Before challenge there was a significant (P less than 0.05) inverse correlation between blood eosinophils and the methacholine PC20. After allergen inhalation eosinophil counts were significantly (P less than 0.01) elevated at 24 hr. These increases in blood eosinophil counts were not observed in patients who developed single early responses. The magnitude of the changes in eosinophil counts (24 hr minus pre-challenge values) also correlated with the baseline methacholine PC20 (P less than 0...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/3931936/exposure-of-hay-fever-subjects-to-an-indoor-environmental-grass-pollen-challenge-system
#17
H J Davies
A new indoor nasal allergen challenge system has been developed which allows subjects with hay fever to be exposed to pre-determined concentration of grass pollen grains in the immediate environment. Thirteen subjects were exposed during the winter months to an atmosphere containing approximately 1000 grains/m3 for 30 min. No changes in nasal airway patency or symptoms of nasal congestion were recorded. It was necessary to increase the pollen concentration to approximately 9000 and 35 000 grains/m3 in two subjects and six subjects respectively, before a positive response was recorded...
September 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4028390/asthma-and-the-month-of-birth
#18
T J David, S C Beards
No abstract text is available yet for this article.
July 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4028389/analysis-of-tobacco-leaf-allergens-by-crossed-radioimmunoelectrophoresis
#19
S B Lehrer, M McCants, L Aukrust, J E Salvaggio
The reactivity of eleven 'tobacco smoke sensitive' and eight 'non-sensitive' individuals to tobacco leaf allergens was tested by Crossed Radioimmunoelectrophoresis (CRIE). All nineteen study subjects had IgE antibodies to tobacco leaf antigens as measured by Radioallergosorbent Test (RAST) and seventeen of the nineteen individuals were atopic. Of the thirty-seven tobacco leaf precipitins detected by Cross Immunoelectrophoresis (CIE), three were identified as allergens by CRIE. All nineteen subjects reacted to at least one of the three allergens detected...
July 1985: Clinical Allergy
https://www.readbyqxmd.com/read/4028388/specific-ige-to-food-and-inhalant-allergens-in-intestinal-washings-of-children-affected-by-atopic-eczema
#20
F Marcucci, L G Sensi, G Bizzarri
Serum and rectal total and specific IgE were measured in eleven children with atopic dermatitis and eight with atopic dermatitis and associated wheezing. Specific IgE to food and inhalant allergens in rectal washings were found in fourteen patients. Of the seventy-six allergens which gave positive results, twenty were positive in both serum and intestine, thirty in serum alone and twenty-six in intestines alone. Specific intestinal IgE were confirmed by food challenge in three out of four patients whose skin-prick test and serum RAST were both negative...
July 1985: Clinical Allergy
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