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Coordination Chemistry Reviews

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https://www.readbyqxmd.com/read/27890939/the-metal-face-of-protein-tyrosine-phosphatase-1b
#1
REVIEW
Elisa Bellomo, Kshetrimayum Birla Singh, Alberto Massarotti, Christer Hogstrand, Wolfgang Maret
A new paradigm in metallobiochemistry describes the activation of inactive metalloenzymes by metal ion removal. Protein tyrosine phosphatases (PTPs) do not seem to require a metal ion for enzymatic activity. However, both metal cations and metal anions modulate their enzymatic activity. One binding site is the phosphate binding site at the catalytic cysteine residue. Oxyanions with structural similarity to phosphate, such as vanadate, inhibit the enzyme with nanomolar to micromolar affinities. In addition, zinc ions (Zn(2+)) inhibit with picomolar to nanomolar affinities...
November 15, 2016: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/26744544/recent-advances-in-multinuclear-metal-nitrosyl-complexes
#2
Lijuan Li, Linlin Li
The coordination chemistry of metal nitrosyls has expanded rapidly in the past decades due to major advances of nitric oxide and its metal compounds in biology. This review article highlights advances made in the area of multinuclear metal nitrosyl complexes, including Roussin's salts and their ester derivatives from 2003 to present. The review article focuses on isolated multinuclear metal nitrosyl complexes and is organized into different sections by the number of metal centers and bridging ligands.
January 1, 2016: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/26688591/biological-signaling-by-small-inorganic-molecules
#3
Debashree Basudhar, Lisa A Ridnour, Robert Cheng, Aparna H Kesarwala, Julie Heinecke, David A Wink
Small redox active molecules such as reactive nitrogen and oxygen species and hydrogen sulfide have emerged as important biological mediators that are involved in various physiological and pathophysiological processes. Advancement in understanding of cellular mechanisms that tightly regulate both generation and reactivity of these molecules is central to improved management of various disease states including cancer and cardiovascular dysfunction. Imbalance in the production of redox active molecules can lead to damage of critical cellular components such as cell membranes, proteins and DNA and thus may trigger the onset of disease...
January 1, 2016: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/26688590/recent-developments-in-hydrogen-evolving-molecular-cobalt-ii-polypyridyl-catalysts
#4
N Queyriaux, R T Jane, J Massin, V Artero, M Chavarot-Kerlidou
The search for efficient noble metal-free hydrogen-evolving catalysts is the subject of intense research activity. A new family of molecular cobalt(II)-polypyridyl catalysts has recently emerged. These catalysts prove more robust under reductive conditions than other cobalt-based systems and display high activities under fully aqueous conditions. This review discusses the design, characterization, and evaluation of these catalysts for electrocatalytic and light-driven hydrogen production. Mechanistic considerations are addressed and structure-catalytic activity relationships identified in order to guide the future design of more efficient catalytic systems...
December 1, 2015: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/26339074/the-use-of-polyoxometalates-in-protein-crystallography-an-attempt-to-widen-a-well-known-bottleneck
#5
Aleksandar Bijelic, Annette Rompel
Polyoxometalates (POMs) are discrete polynuclear metal-oxo anions with a fascinating variety of structures and unique chemical and physical properties. Their application in various fields is well covered in the literature, however little information about their usage in protein crystallization is available. This review summarizes the impact of the vast class of POMs on the formation of protein crystals, a well-known (frustrating) bottleneck in macromolecular crystallography, with the associated structure elucidation and a particular emphasis focused on POM's potential as a powerful crystallization additive for future research...
September 1, 2015: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/25729089/control-and-utilization-of-ruthenium-and-rhodium-metal-complex-excited-states-for-photoactivated-cancer-therapy
#6
Jessica D Knoll, Claudia Turro
The use of visible light to produce highly selective and potent drugs through photodynamic therapy (PDT) holds much potential in the treatment of cancer. PDT agents can be designed to follow an O2-dependent mechanism by producing highly reactive species such as (1)O2 and/or an O2 independent mechanism through processes such as excited state electron transfer, covalent binding to DNA or photoinduced drug delivery. Ru(II)-polypyridyl and Rh2(II,II) complexes represent an important class of compounds that can be tailored to exhibit desired photophysical properties and photochemical reactivity by judicious selection of the ligand set...
January 1, 2015: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/25237207/the-structural-basis-of-action-of-vanadyl-vo-2-chelates-in-cells
#7
Marvin W Makinen, Marzieh Salehitazangi
Much emphasis has been given to vanadium compounds as potential therapeutic reagents for the treatment of diabetes mellitus. Thus far, no vanadium compound has proven efficacious for long-term treatment of this disease in humans. Therefore, in review of the research literature, our goal has been to identify properties of vanadium compounds that are likely to favor physiological and biochemical compatibility for further development as therapeutic reagents. We have, therefore, limited our review to those vanadium compounds that have been used in both in vivo experiments with small, laboratory animals and in in vitro studies with primary or cultured cell systems and for which pharmacokinetic and pharmacodynamics results have been reported, including vanadium tissue content, vanadium and ligand lifetime in the bloodstream, structure in solution, and interaction with serum transport proteins...
November 1, 2014: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/25009361/the-coordination-chemistry-and-magnetism-of-some-3d-4f-and-4f-amino-polyalcohol-compounds
#8
Joseph W Sharples, David Collison
Triethanolamine, teaH3, and diethanolamine, RdeaH2, 3d-4f and 4f compounds demonstrate an enormous variety in their structure and bonding. This review examines the synthetic strategies to these molecules and their magnetic properties, whilst trying to assess these ligands' suitability towards new SMMs and magnetic refrigerants.
February 1, 2014: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/23997273/designing-functional-metalloproteins-from-structural-to-catalytic-metal-sites
#9
Melissa L Zastrow, Vincent L Pecoraro
Metalloenzymes efficiently catalyze some of the most important and difficult reactions in nature. For many years, coordination chemists have effectively used small molecule models to understand these systems. More recently, protein design has been shown to be an effective approach for mimicking metal coordination environments. Since the first designed proteins were reported, much success has been seen for incorporating metal sites into proteins and attaining the desired coordination environment but until recently, this has been with a lack of significant catalytic activity...
September 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/24850951/structure-and-function-of-atypically-coordinated-enzymatic-mononuclear-non-heme-fe-ii-centers
#10
Daniela Buongiorno, Grit D Straganz
Mononuclear, non-heme-Fe(II) centers are key structures in O2 metabolism and catalyze an impressive variety of enzymatic reactions. While most are bound via two histidines and a carboxylate, some show a different organization. A short overview of atypically coordinated O2 dependent mononuclear-non-heme-Fe(II) centers is presented here Enzymes with 2-His, 3-His, 3-His-carboxylate and 4-His bound Fe(II) centers are discussed with a focus on their reactivity, metal ion promiscuity and recent progress in the elucidation of their enzymatic mechanisms...
January 15, 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/23525635/x-ray-absorption-near-edge-spectroscopy-in-bioinorganic-chemistry-application-to-m-o2-systems
#11
Ritimukta Sarangi
Metal K-edge X-ray absorption spectroscopy (XAS) has been extensively applied to bioinorganic chemistry to obtain geometric structure information on metalloprotein and biomimetic model complex active sites by analyzing the higher energy extended X-ray absorption fine structure (EXAFS) region of the spectrum. In recent years, focus has been on developing methodologies to interpret the lower energy K-pre-edge and rising-edge regions (XANES) and using it for electronic structure determination in complex bioinorganic systems...
January 15, 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/23471138/co-no-and-o2-as-vibrational-probes-of-heme-protein-interactions
#12
Thomas G Spiro, Alexandra V Soldatova, Gurusamy Balakrishnan
The gaseous XO molecules (X = C, N or O) bind to the heme prosthetic group of heme proteins, and thereby activate or inhibit key biological processes. These events depend on interactions of the surrounding protein with the FeXO adduct, interactions that can be monitored via the frequencies of the Fe-X and X-O bond stretching modes, νFeX and νXO. The frequencies can be determined by vibrational spectroscopy, especially resonance Raman spectroscopy. Backbonding, the donation of Fe dπ electrons to the XO π* orbitals, is a major bonding feature in all the FeXO adducts...
January 15, 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/23470857/ferritins-for-chemistry-and-for-life
#13
Elizabeth C Theil, Rabindra K Behera, Takehiko Tosha
Ferritins, highly symmetrical protein nanocages, are reactors for Fe2+ and dioxygen or hydrogen peroxide that are found in all kingdoms of life and in many different cells of multicellular organisms. They synthesize iron concentrates required for cells to make cofactors of iron proteins (heme, FeS, mono and diiron). The caged ferritin biominerals, Fe2O3•H2O are also antioxidants, acting as sinks for iron and oxidants scavenged from damaged proteins; genetic regulation of ferritin biosynthesis is sensitive to both iron and oxidants...
January 15, 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/24368870/novel-approaches-for-the-accumulation-of-oxygenated-intermediates-to-multi-millimolar-concentrations
#14
Carsten Krebs, Laura M K Dassama, Megan L Matthews, Wei Jiang, John C Price, Victoria Korboukh, Ning Li, J Martin Bollinger
Metalloenzymes that utilize molecular oxygen as a co-substrate catalyze a wide variety of chemically difficult oxidation reactions. Significant insight into the reaction mechanisms of these enzymes can be obtained by the application of a combination of rapid kinetic and spectroscopic methods to the direct structural characterization of intermediate states. A key limitation of this approach is the low aqueous solubility (< 2 mM) of the co-substrate, O2, which undergoes further dilution (typically by one-third or one-half) upon initiation of reactions by rapid-mixing...
January 1, 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/23470920/kinetics-and-thermodynamics-of-formation-and-electron-transfer-reactions-of-cu-o2-and-cu2-o2-complexes
#15
Shunichi Fukuzumi, Kenneth D Karlin
The kinetics and thermodynamics of formation of Cu(II)-superoxo (Cu-O2) complexes by the reaction of Cu(I) complexes with dioxygen (O2) and the reduction of Cu(II)-superoxo complexes to dinuclear Cu-peroxo complexes are discussed. In the former case, electron transfer from a Cu(I) complex to O2 occurs concomitantly with binding of O2 •- to the corresponding Cu(II) species. This is defined as an inner-sphere Cu(II) ion-coupled electron transfer process. Electron transfer from another Cu(I) complex to preformed Cu(II)-superoxo complexes also occurs concomitantly with binding of the the Cu(II)-peroxo species with the Cu(II) species to produce the dinuclear Cu-peroxo (Cu2-O2) complexes...
January 1, 2013: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/25364029/light-driven-water-oxidation-for-solar-fuels
#16
Karin J Young, Lauren A Martini, Rebecca L Milot, Robert C Snoeberger Iii, Victor S Batista, Charles A Schmuttenmaer, Robert H Crabtree, Gary W Brudvig
Light-driven water oxidation is an essential step for conversion of sunlight into storable chemical fuels. Fujishima and Honda reported the first example of photoelectrochemical water oxidation in 1972. In their system, TiO2 was irradiated with ultraviolet light, producing oxygen at the anode and hydrogen at a platinum cathode. Inspired by this system, more recent work has focused on functionalizing nanoporous TiO2 or other semiconductor surfaces with molecular adsorbates, including chromophores and catalysts that absorb visible light and generate electricity (i...
November 1, 2012: Coordination Chemistry Reviews
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