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Ophthalmic Research

Jeremy Tan, Ute Vollmer-Conna, Lien Tat, Minas Coroneo
PURPOSE: The aim of this paper was to investigate the degree of inflammation and dry-eye disease (DED) in recurrent pterygium. METHODS: Fifty-five patients with a history of pterygium excision were divided into 3 groups - Group 1: no recurrence after the first excision; Group 2: recurrence after the first excision; Group 3: no recurrence after the second excision. Dry-eye symptoms and tear production were elicited for each patient. RESULTS: A high prevalence of DED was observed in patients with primary and recurrent pterygium based on self-reported dry-eye symptoms (63...
October 31, 2018: Ophthalmic Research
Jing Feng, Bing Li, Jing Wen, Yanrong Jiang
OBJECTIVE: To evaluate the changes in aqueous concentrations of inflammatory cytokines and fibrosis-related factors, and to detect the expression of vascular endothelial growth factor (VEGF) and proliferating cells in fibrovascular membranes (FVMs) of patients with proliferative diabetic retinopathy (PDR) after injection of intravitreal bevacizumab (IVB). METHODS: Forty-two eyes of 42 patients with PDR, including 28 eyes that received IVB (1.25 mg) 2, 5, and 14 days before pars plana vitrectomy (PPV), and 14 eyes without IVB, were enrolled, in addition to 10 eyes of 10 patients with nondiabetic ocular diseases...
October 31, 2018: Ophthalmic Research
Taneto Tomiyasu, Yoshio Hirano, Norihiro Suzuki, Yuya Esaki, Yusuke Yasuda, Akiyoshi Uemura, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To study the structural and functional changes of retinal ischemia and investigate their association with macular edema (ME) or microaneurysm (MA) formation in eyes with retinal vein occlusion (RVO). METHODS: Sixty eyes of 30 patients (27 eyes with branch [b]RVO, 3 with central RVO, and 30 fellow eyes) were retrospectively reviewed. Optical coherence tomography (OCT), OCT angiography (OCTA), and microperimetry were performed simultaneously to measure retinal thickness and sensitivity...
October 25, 2018: Ophthalmic Research
Yuki Nakamoto, Ryota Takada, Minatsu Tanaka, Fumiko Matsumoto, Keiichi Aomatsu, Kuniko Tachibana, Hiroshi Eguchi, Shunji Kusaka
PURPOSE: This study aimed to evaluate the utility of optical coherence tomography (OCT) in the quantification of eccentric fixation in amblyopic patients. MATERIAL AND METHODS: In this study, 14 amblyopic patients and 10 healthy volunteers were enrolled. Under non-mydriatic conditions, fixation tests were performed directly using a fixation ophthalmoscope and indirectly using spectral-domain OCT. For evaluations using OCT, the distance between the fovea and the fixation point, which was determined by a cross-sectional image, was measured...
October 16, 2018: Ophthalmic Research
Gilda Cennamo, Vittoria Lanni, Rosa Abbate, Nunzio Velotti, Federica Fossataro, Federica Sparnelli, Mario R Romano, Giuseppe de Crecchio, Giovanni Cennamo
AIM: Macular pigment density and microvascular density on optical coherence tomography angiography (OCTA) were measured in a cohort of type 1 diabetes mellitus (T1DM) patients with retinopathy in the attempt to shed light on the pathophysiology of this condition. METHODS: Eighty-two consecutive eyes of 59 patients with diabetic retinopathy examined at the Eye Clinic of the University of Naples Federico II from November 2016 to April 2017 were enrolled in this prospective study...
October 11, 2018: Ophthalmic Research
Takao Hirano, Yuichi Toriyama, Yasuhiro Iesato, Akihiro Ishibazawa, Masahiko Sugimoto, Yoshihiro Takamura, Taiji Nagaoka, Toshinori Murata
PURPOSE: Evaluate the effect of foveal leaking microaneurysms (MAs) on the required number of intravitreal ranibiz-umab (IVR) injections in the treatment of center-involving diabetic macular edema (DME) when treated with focal/grid laser. DESIGN: A pilot study of prospective, nonrandomized, multicenter clinical trial. METHODS: This study enrolled 21 eyes with DME for which pro re nata IVR injections were combined with short-pulse focal/grid laser...
October 10, 2018: Ophthalmic Research
Giovanni Cennamo, Maria Angelica Breve, Nunzio Velotti, Federica Sparnelli, Claudio Iovino, Antonio Farella, Raffaele Liuzzi, Giuseppe de Crecchio, Gilda Cennamo
AIM: The purpose of this paper was to evaluate whether optical coherence tomography angiography (OCT-A) can be used to quantify the vascular changes in radiation maculopathy, and changes in the tumor vasculature in eyes treated with plaque radiotherapy for choroidal melanoma. METHODS: In this prospective study, we evaluated 39 Caucasian patients with choroidal melanoma (39 eyes) treated with ruthenium-106 plaque radiotherapy. The patients underwent complete ophthalmic examination, bulbar echography, and OCT-A before and 1 year after treatment...
August 17, 2018: Ophthalmic Research
Hatem Zayed, Ussama M Abdel Motal, Akila Gopalakrishnan, Chinnayan Ponnuraja, C George Priya Doss, Nasser Rizk, Fatma M Shebl
AIMS: To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. METHODS: We systematically searched 4 different literature databases (PubMed, Science Direct, Web of Science and Embase), from the date of inception until December 2017, to collect all the information about patients with T1D who developed retinopathy complications; for statistical analysis, we used MetaXL to evaluate the pooled prevalence estimate and the subgroup prevalence estimates employing double arcsine transformation and inverse variance heterogeneity models...
July 25, 2018: Ophthalmic Research
Teresa Rolle, Laura Dallorto, Marco Tavassoli, Raffaele Nuzzi
PURPOSE: To evaluate papillary, peripapillary, and macular vasculature with optical coherence tomography angiography in preperimetric (PPG), primary open-angle glaucoma (POAG), and normal eyes, and to assess diagnostic ability and associations among the vasculature and structural damage. METHODS: This was an observational, cross-sectional study. Retinal nerve fiber layer (RNFL), ganglion cell complex thickness, whole-image (wiVD), inside disc (idVD), peripapillary (ppVD), and macular vessel densities were obtained...
June 28, 2018: Ophthalmic Research
Rupert W Strauss, Xiangrong Kong, Millena G Bittencourt, Alexander Ho, Anamika Jha, Etienne M Schönbach, Mohamed I Ahmed, Beatriz Muñoz, Ann-Margret Ervin, Michel Michaelides, David G Birch, José-Alain Sahel, Janet S Sunness, Eberhart Zrenner, Saghar Bagheri, Michael Ip, SriniVas Sadda, Sheila West, Hendrik P N Scholl
PURPOSE: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. METHODS: Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF)...
June 25, 2018: Ophthalmic Research
Christoph Leisser, Stefan Palkovits, Nino Hirnschall, Marlies Ullrich, Julius Hienert, Hannah Zwickl, Stefan Georgiev, Oliver Findl
PURPOSE: Internal limiting membrane (ILM) flap transposition in surgical repair of macular holes represents a new technique offering good anatomical success rates with large macular holes. The aim of the study was to examine microperimetric outcomes 1 year after ILM flap transposition for surgical repair of macular holes. METHODS: Patients with idi-opathic macular holes scheduled for 23-G pars plana vitrectomy with ILM peeling, ILM flap transposition, and SF6 tamponade were examined in a prospective case series...
June 22, 2018: Ophthalmic Research
Qing Peng, Yutong Chen, Rui Hua
AIM: To establish a novel retinal angiography method, red-free angiography (RFA), to investigate retinal changes in age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). METHODS: Following the venous phase of fundus fluorescein angiography (FFA), the detection mode was switched to red-free reflectance to acquire RFA images using the same parameters. RESULTS: RFA showed subretinal fluid, polyps, and outer retinal tubulation, with a higher definition than the FFA and red-free reflectance results...
June 7, 2018: Ophthalmic Research
Philipp Simon Koelbl, Jens Ulrich Werner, Christian Enders, Christian Lingenfelder, Frank H J Koch, Martin Hessling
PURPOSE: Surgical or diagnostic procedures are often accompanied by a short-term increase in intraocular pressure (IOP). A short-term increase in IOP can occur during refractive procedures, vitreoretinal surgery, transillumination, photocoagulation, or cryocoagulation. A porcine eye model was chosen (n = 89) to compile comparable study data and to de termine correlations between the force induced and the resulting intraocular pressure while excluding the effect of surgeons. METHODS: The IOP was measured in the anterior chamber...
May 31, 2018: Ophthalmic Research
Osamu Kotake, Hidetaka Noma, Kanako Yasuda, Ryosuke Motohashi, Hiroshi Goto, Masahiko Shimura
PURPOSE: To investigate dynamic changes in aqueous humor levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and inflammatory factors in patients receiving intravitreal ranibizumab injection (IRI) or intravitreal aflibercept injection (IAI) to treat central retinal vein occlusion (CRVO) with macular edema. METHODS: In 22 CRVO patients scheduled to receive 3 doses of ranibizumab (11 eyes) or aflibercept (11 eyes) at monthly intervals, aqueous samples were collected at the time of intravitreal injection...
May 25, 2018: Ophthalmic Research
Chun Ding, Shengguo Li, Jun Zeng
PURPOSE: The aim of this study was to demonstrate the surgical technique and clinical outcome of autologous neurosensory retinal patch transplantation for recurrent large macular hole (MH)-induced retinal detachment after failed surgery with internal limiting membrane (ILM) removal or transplantation. METHODS: We reviewed 5 patients with recurrent MH-induced retinal detachment after failed surgeries with ILM removal or transplantation who underwent vitrectomy combined with autologous neurosensory retinal patch transplantations and were followed up over 6 months...
May 22, 2018: Ophthalmic Research
Yusuke Yasuda, Yoshio Hirano, Yuya Esaki, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To evaluate the location of microvascular abnormalities using wide-field fluorescein angiography (WFFA) and investigate the impact on visual outcome in eyes with branch retinal vein occlusion (BRVO). METHODS: Forty eyes of 39 patients (24 males and 15 females with an average age of 71 years) were retrospectively reviewed. One patient had BRVO bilaterally. WFFA was performed in all patients to evaluate perfusion status and detect microvascular abnormalities...
May 22, 2018: Ophthalmic Research
Giuseppe Giannaccare, Aldo Vagge, Stefano Sebastiani, Lara E Urbini, Paolo Corazza, Marco Pellegrini, Luciana Carmassi, Fulvio Bergamini, Carlo E Traverso, Emilio C Campos
PURPOSE: The aim of this study was to evaluate the safety and efficacy of ultrasound cyclo-plasty (UCP) for reducing intraocular pressure (IOP) in patients with glaucoma. METHODS: This is a multicentre prospective study conducted in 3 Italian glaucoma centres. UCP was performed by EyeOP1, which delivers ultrasound beams using 6 piezoelectric transducers activated for 4/6 s (first generation) or 8 s (second generation). Primary outcomes were the mean IOP reduction and the rates of success after 1 year...
May 16, 2018: Ophthalmic Research
Huiyuan Hou, Eric Nudleman, Robert N Weinreb
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.
May 3, 2018: Ophthalmic Research
Wen Lin, Guoxing Xu
Autophagy is a lysosomal degradation process that maintains cellular homeostasis by removing dysfunctional organelles and unfolded proteins. Increasing evidence has shown that autophagy proteins are involved in retinal physiology and pathology and that defective autophagy contributes to retinal degeneration. In retinal diseases, autophagy plays a dual role: promoting retinal cell survival and death. Autophagy at a normal level helps retinal cells defend themselves against harmful stress; however, excessive autophagy results in retinal deterioration...
April 25, 2018: Ophthalmic Research
Xiao Na Wang, Qi Sheng You, Qian Li, Yang Li, Yu Mao, Feng Hu, Hui Ying Zhao, Frank F Tsai, Xiao Yan Peng
PURPOSE: To evaluate the vascular anatomy of eyes with Best vitelliform macular dystrophy (BVMD) using optical coherence tomography angiography (OCTA). METHODS: This retrospective case-control study enrolled 11 consecutive BVMD patients and 13 age-matched healthy participants. Both eyes of each participant were imaged using a macular OCTA scan (3 × 3 mm) by 70-kHz 840-nm spectral-domain OCT. The flow signal was calculated using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm...
April 13, 2018: Ophthalmic Research
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