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Ophthalmic Research

Ana Penedones, Francisco Batel Marques
PURPOSE: This systematic review aims to characterize and review the methodology of the systematic reviews reporting ophthalmic adverse drug reactions. METHODS: This systematic review followed the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-analyses guide. MEDLINE and EMBASE databases were searched, by all Ophthalmology journals. All systematic reviews reporting ophthalmic adverse drug reactions in the last decade were included...
July 5, 2018: Ophthalmic Research
Heba A Hassan, Mahmoud M Geniady, Sayed F Abdelwahab, Manal I Abd-Elghany, Hatem A Sarhan, Ahmed A Abdelghany, Mohamed S Kamel, Alejandra E Rodriguez, Jorge L Alio
PURPOSE: To determine the efficacy of eugenol for the treatment of Candida keratitis in an experimental model. METHODS: The in vitro antifungal activity of eugenol and fluconazole was tested against C. albicans strains via the microbroth dilution method. An experimental model of Candida albicans keratitis was used. Rabbits were classified into those that received no treatment (control; group 1) and those that started eugenol treatment immediately (group 2) or after 4 days (group 3) of keratitis induction (n = 12-16 rabbits/group)...
July 3, 2018: Ophthalmic Research
Teresa Rolle, Laura Dallorto, Marco Tavassoli, Raffaele Nuzzi
PURPOSE: To evaluate papillary, peripapillary, and macular vasculature with optical coherence tomography angiography in preperimetric (PPG), primary open-angle glaucoma (POAG), and normal eyes, and to assess diagnostic ability and associations among the vasculature and structural damage. METHODS: This was an observational, cross-sectional study. Retinal nerve fiber layer (RNFL), ganglion cell complex thickness, whole-image (wiVD), inside disc (idVD), peripapillary (ppVD), and macular vessel densities were obtained...
June 28, 2018: Ophthalmic Research
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June 27, 2018: Ophthalmic Research
Rupert W Strauss, Xiangrong Kong, Millena G Bittencourt, Alexander Ho, Anamika Jha, Etienne M Schönbach, Mohamed I Ahmed, Beatriz Muñoz, Ann-Margret Ervin, Michel Michaelides, David G Birch, José-Alain Sahel, Janet S Sunness, Eberhart Zrenner, Saghar Bagheri, Michael Ip, SriniVas Sadda, Sheila West, Hendrik P N Scholl
PURPOSE: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. METHODS: Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF)...
June 25, 2018: Ophthalmic Research
Christoph Leisser, Stefan Palkovits, Nino Hirnschall, Marlies Ullrich, Julius Hienert, Hannah Zwickl, Stefan Georgiev, Oliver Findl
PURPOSE: Internal limiting membrane (ILM) flap transposition in surgical repair of macular holes represents a new technique offering good anatomical success rates with large macular holes. The aim of the study was to examine microperimetric outcomes 1 year after ILM flap transposition for surgical repair of macular holes. METHODS: Patients with idi-opathic macular holes scheduled for 23-G pars plana vitrectomy with ILM peeling, ILM flap transposition, and SF6 tamponade were examined in a prospective case series...
June 22, 2018: Ophthalmic Research
Dario Rusciano, Salvatore Pezzino, Melania Olivieri, Martina Cristaldi, Caterina Gagliano, Gabriella Lupo, Carmelina Daniela Anfuso
Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex (being more frequent among women) and age (increasing with aging). Therefore, specific treatments taking into account the etiology of the disease would be desired. The role of lactoferrin and its functional mimetic lactobionic acid are reported here as a possible remedy for age-related dry eye...
June 19, 2018: Ophthalmic Research
Hyun-Kyung Cho, Min Gyu Lee, Changwon Kee
PURPOSE: This study aimed to investigate the association of the frequency of optic disk hemorrhage (DH) and progression of normal tension glaucoma (NTG) between each group based on the location of the initial retinal nerve fiber layer (RNFL) defect. METHODS: In this retrospective, observational cohort study, 142 NTG patients who underwent more than 5 reliable visual field tests with initial superior hemifield (group 2, n = 51), inferior hemifield (group 1, n = 44), or both hemifield (group 3, n = 47) defects were included...
June 12, 2018: Ophthalmic Research
Ronald Mauricio Sanchez-Avila, Jesus Merayo-Lloves, Maria Laura Fernandez, Luis Alberto Rodriguez-Gutierrez, Nancy Jurado, Francisco Muruzabal, Gorka Orive, Eduardo Anitua
PURPOSE: The aim of this study was to evaluate the use of plasma rich in growth factors (PRGF) eye drops in patients with dry eye disease after laser-assisted in situ keratomileusis (LASIK) surgery. MATERIAL AND METHODS: This is a longitudinal, retrospective, comparative, and descriptive study of 77 eyes of 42 patients with dry eye disease following LASIK surgery. This study was designed to evaluate the efficacy of PRGF treatment compared to conventional therapy (control group)...
June 8, 2018: Ophthalmic Research
Qing Peng, Yutong Chen, Rui Hua
AIM: To establish a novel retinal angiography method, red-free angiography (RFA), to investigate retinal changes in age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). METHODS: Following the venous phase of fundus fluorescein angiography (FFA), the detection mode was switched to red-free reflectance to acquire RFA images using the same parameters. RESULTS: RFA showed subretinal fluid, polyps, and outer retinal tubulation, with a higher definition than the FFA and red-free reflectance results...
June 7, 2018: Ophthalmic Research
Lorena Lam-Franco, Yocanxochitl Perfecto-Avalos, Beatriz E Patiño-Ramírez, Alejandro Rodríguez García
AIMS: The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline. METHODS: After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), lacrimal samples were analyzed using an enzyme-linked immunosorbent assay multiplex. RESULTS: There was a significant difference between baseline IL-1α (37...
June 6, 2018: Ophthalmic Research
Philipp Simon Koelbl, Jens Ulrich Werner, Christian Enders, Christian Lingenfelder, Frank H J Koch, Martin Hessling
PURPOSE: Surgical or diagnostic procedures are often accompanied by a short-term increase in intraocular pressure (IOP). A short-term increase in IOP can occur during refractive procedures, vitreoretinal surgery, transillumination, photocoagulation, or cryocoagulation. A porcine eye model was chosen (n = 89) to compile comparable study data and to de termine correlations between the force induced and the resulting intraocular pressure while excluding the effect of surgeons. METHODS: The IOP was measured in the anterior chamber...
May 31, 2018: Ophthalmic Research
Almutez M Gharaibeh, Virginia Saez, Nerea Garcia, Laurent Bataille, Jorge L Alió
PURPOSE: Studying genipin variable concentrations, treatment durations, and delivery methods as a substance to increase corneal stiffness by inducing corneal collagen cross-linking (CXL). MATERIALS AND METHODS: 100 bovine corneas treated with different genipin concentrations (0.1, 0.5, and 1%) and treatment durations (15 min, 40 min, 2 h, and 3 days) through different delivery methods compared to 10 controls treated with riboflavin/UV. Histology examination, enzymatic digestion with collagenase and thermal differential scanning calorimetry were performed on the different samples...
May 25, 2018: Ophthalmic Research
Osamu Kotake, Hidetaka Noma, Kanako Yasuda, Ryosuke Motohashi, Hiroshi Goto, Masahiko Shimura
PURPOSE: To investigate dynamic changes in aqueous humor levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and inflammatory factors in patients receiving intravitreal ranibizumab injection (IRI) or intravitreal aflibercept injection (IAI) to treat central retinal vein occlusion (CRVO) with macular edema. METHODS: In 22 CRVO patients scheduled to receive 3 doses of ranibizumab (11 eyes) or aflibercept (11 eyes) at monthly intervals, aqueous samples were collected at the time of intravitreal injection...
May 25, 2018: Ophthalmic Research
Lukas Van Melkebeke, João Barbosa-Breda, Marc Huygens, Ingeborg Stalmans
BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking...
May 24, 2018: Ophthalmic Research
Chun Ding, Shengguo Li, Jun Zeng
PURPOSE: The aim of this study was to demonstrate the surgical technique and clinical outcome of autologous neurosensory retinal patch transplantation for recurrent large macular hole (MH)-induced retinal detachment after failed surgery with internal limiting membrane (ILM) removal or transplantation. METHODS: We reviewed 5 patients with recurrent MH-induced retinal detachment after failed surgeries with ILM removal or transplantation who underwent vitrectomy combined with autologous neurosensory retinal patch transplantations and were followed up over 6 months...
May 22, 2018: Ophthalmic Research
Yusuke Yasuda, Yoshio Hirano, Yuya Esaki, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To evaluate the location of microvascular abnormalities using wide-field fluorescein angiography (WFFA) and investigate the impact on visual outcome in eyes with branch retinal vein occlusion (BRVO). METHODS: Forty eyes of 39 patients (24 males and 15 females with an average age of 71 years) were retrospectively reviewed. One patient had BRVO bilaterally. WFFA was performed in all patients to evaluate perfusion status and detect microvascular abnormalities...
May 22, 2018: Ophthalmic Research
Giuseppe Giannaccare, Aldo Vagge, Stefano Sebastiani, Lara E Urbini, Paolo Corazza, Marco Pellegrini, Luciana Carmassi, Fulvio Bergamini, Carlo E Traverso, Emilio C Campos
PURPOSE: The aim of this study was to evaluate the safety and efficacy of ultrasound cyclo-plasty (UCP) for reducing intraocular pressure (IOP) in patients with glaucoma. METHODS: This is a multicentre prospective study conducted in 3 Italian glaucoma centres. UCP was performed by EyeOP1, which delivers ultrasound beams using 6 piezoelectric transducers activated for 4/6 s (first generation) or 8 s (second generation). Primary outcomes were the mean IOP reduction and the rates of success after 1 year...
May 16, 2018: Ophthalmic Research
Huiyuan Hou, Eric Nudleman, Robert N Weinreb
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.
May 3, 2018: Ophthalmic Research
Wen Lin, Guoxing Xu
Autophagy is a lysosomal degradation process that maintains cellular homeostasis by removing dysfunctional organelles and unfolded proteins. Increasing evidence has shown that autophagy proteins are involved in retinal physiology and pathology and that defective autophagy contributes to retinal degeneration. In retinal diseases, autophagy plays a dual role: promoting retinal cell survival and death. Autophagy at a normal level helps retinal cells defend themselves against harmful stress; however, excessive autophagy results in retinal deterioration...
April 25, 2018: Ophthalmic Research
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