journal
MENU ▼
Read by QxMD icon Read
search

Ophthalmic Research

journal
https://www.readbyqxmd.com/read/29768281/ultrasound-cyclo-plasty-in-patients-with-glaucoma-1-year-results-from-a-multicentre-prospective-study
#1
Giuseppe Giannaccare, Aldo Vagge, Stefano Sebastiani, Lara E Urbini, Paolo Corazza, Marco Pellegrini, Luciana Carmassi, Fulvio Bergamini, Carlo E Traverso, Emilio C Campos
PURPOSE: The aim of this study was to evaluate the safety and efficacy of ultrasound cyclo-plasty (UCP) for reducing intraocular pressure (IOP) in patients with glaucoma. METHODS: This is a multicentre prospective study conducted in 3 Italian glaucoma centres. UCP was performed by EyeOP1, which delivers ultrasound beams using 6 piezoelectric transducers activated for 4/6 s (first generation) or 8 s (second generation). Primary outcomes were the mean IOP reduction and the rates of success after 1 year...
May 16, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29723860/animal-models-of-proliferative-vitreoretinopathy-and-their-use-in-pharmaceutical-investigations
#2
Huiyuan Hou, Eric Nudleman, Robert N Weinreb
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.
May 3, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29694961/autophagy-a-role-in-the-apoptosis-survival-inflammation-and-development-of-the-retina
#3
Wen Lin, Guoxing Xu
Autophagy is a lysosomal degradation process that maintains cellular homeostasis by removing dysfunctional organelles and unfolded proteins. Increasing evidence has shown that autophagy proteins are involved in retinal physiology and pathology and that defective autophagy contributes to retinal degeneration. In retinal diseases, autophagy plays a dual role: promoting retinal cell survival and death. Autophagy at a normal level helps retinal cells defend themselves against harmful stress; however, excessive autophagy results in retinal deterioration...
April 25, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29656284/findings-of-optical-coherence-tomography-angiography-in-best-vitelliform-macular-dystrophy
#4
Xiao Na Wang, Qi Sheng You, Qian Li, Yang Li, Yu Mao, Feng Hu, Hui Ying Zhao, Frank F Tsai, Xiao Yan Peng
PURPOSE: To evaluate the vascular anatomy of eyes with Best vitelliform macular dystrophy (BVMD) using optical coherence tomography angiography (OCTA). METHODS: This retrospective case-control study enrolled 11 consecutive BVMD patients and 13 age-matched healthy participants. Both eyes of each participant were imaged using a macular OCTA scan (3 × 3 mm) by 70-kHz 840-nm spectral-domain OCT. The flow signal was calculated using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm...
April 13, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29649796/visual-field-variability-after-gene-therapy-for-leber-s-hereditary-optic-neuropathy
#5
Jia-Jia Yuan, Yong Zhang, Li-Ling Wang, Ming-Shi Cheng, Si-Qi Ma, Qin Gao, Bin Li
PURPOSE: To assess changes in visual field (VF) values after gene therapy for Leber's hereditary optic neuropathy (LHON). METHODS: VF recovery, VF indices, and mean deviation in injected and uninjected eyes, before and after gene therapy, were examined in 2 groups of patients according to disease duration (≤2 years and > 2 years). Nine patients with LHON were treated by monocular intravitreal injection of AAV2-ND4. Finally, 7 patients were considered for subsequent comparisons; the first and second eyes were treated separately...
April 12, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29642065/a-pathogenetic-classification-of-diabetic-macular-edema
#6
Maurizio Parodi Battaglia, Pierluigi Iacono, Marialucia Cascavilla, Ilaria Zucchiatti, Francesco Bandello
PURPOSE: The aim of this study was to define a new pathogenetic classification of diabetic macular edema (DME) and to present the results of its application in common clinical practice. METHODS: One hundred and seventy-seven consecutive patients with center-involving DME, central retinal thickness (CRT) ≥250 µm, were prospectively enrolled. A complete ophthalmological examination included best-corrected visual acuity (BCVA) assessment, fundus photography, and spectral-domain optical coherence tomography (OCT)...
April 11, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29635229/cyclophosphamide-or-rituximab-treatment-of-scleritis-and-uveitis-for-patients-with-granulomatosis-with-polyangiitis
#7
Aseef Ahmed, C Stephen Foster
PURPOSE: Vision-threatening ocular inflammation can be a devastating complication of granulomatosis with polyangiitis (GPA). Here we performed a retrospective observational study to describe the safety and efficacy of treating scleritis and uveitis with either cyclophosphamide or rituximab in GPA. METHODS: A chart review of patients diagnosed with GPA-associated scleritis or uveitis, treated with either cyclophosphamide or rituximab as the final therapy at our clinic, was conducted...
April 10, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29627838/assessment-of-corneal-changes-associated-with-topical-antiglaucoma-therapy-using-in-vivo-confocal-microscopy
#8
Elmira Baghdasaryan, Tudor C Tepelus, Laura A Vickers, Ping Huang, Vikas Chopra, SriniVas R Sadda, Olivia L Lee
PURPOSE: Ocular surface disease (OSD) is highly prevalent in eyes treated with chronic, topical antiglaucoma (A/G) therapy. The purpose of this study was to utilize in vivo confocal microscopy (IVCM) to evaluate the corneal morphology, including characteristics of corneal epithelial cells, presence of epithelial dendritic cells (DCs), and characteristics of subbasal nerve plexus, of eyes under topical A/G therapy versus normal eyes. METHODS: Central corneal images were prospectively captured from 30 eyes of 16 patients under topical A/G therapy (>6 months) and 20 normal control eyes, using IVCM (HRT 3 RCM, Heidelberg, Germany)...
April 7, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29627826/meibomian-gland-dysfunction-in-primary-and-secondary-sj%C3%A3-gren-syndrome
#9
David A Sullivan, Reza Dana, Rose M Sullivan, Kathleen L Krenzer, Afsun Sahin, Beril Arica, Yang Liu, Wendy R Kam, Athena S Papas, Jennifer M Cermak
PURPOSE: We hypothesized that women with primary (pSS) and secondary Sjögren syndrome (sSS; with systemic lupus erythematosus [SLE] or rheumatoid arthritis [RA]) have meibomian gland dysfunction (MGD). We sought to test our hypothesis. METHODS: Subjects with pSS, sSS + SLE, sSS + RA, and non-SS-related MGD were recruited from the Sjögren's Syndrome Foundation or outpatient clinics at Tufts University School of Dental Medicine or Brigham and Women's Hospital. The control population was recruited from the Greater Boston area...
April 6, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29621759/peripheral-retinal-imaging-biomarkers-for-alzheimer-s-disease-a-pilot-study
#10
Lajos Csincsik, Thomas J MacGillivray, Erin Flynn, Enrico Pellegrini, Giorgos Papanastasiou, Neda Barzegar-Befroei, Adrienne Csutak, Alan C Bird, Craig W Ritchie, Tunde Peto, Imre Lengyel
PURPOSE: To examine whether ultra-widefield (UWF) retinal imaging can identify biomarkers for Alzheimer's disease (AD) and its progression. METHODS: Images were taken using a UWF scanning laser ophthalmoscope (Optos P200C AF) to determine phenotypic variations in 59 patients with AD and 48 healthy controls at baseline (BL). All living participants were invited for a follow-up (FU) after 2 years and imaged again (if still able to participate). All participants had blood taken for genotyping at BL...
April 5, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29597206/curcumin-alleviates-diabetic-retinopathy-in-experimental-diabetic-rats
#11
Fang Yang, Jinqiang Yu, Feng Ke, Mei Lan, Dekun Li, Ke Tan, Jiaojiao Ling, Ying Wang, Kaili Wu, Dai Li
PURPOSE: To investigate the potential protective effects of curcumin on the retina in diabetic rats. METHODS: An experimental diabetic rat model was induced by a low dose of streptozotocin combined with a high-energy diet. Rats which had blood glucose levels ≥11.6 mmol/L were used as diabetic rats. The diabetic rats were randomly divided into 3 groups: diabetic rats with no treatment (DM), diabetic rats treated with 100 mg/kg curcumin (DM + Cur 100 mg/kg), and diabetic rats treated with 200 mg/kg curcumin (DM + Cur 200 mg/kg)...
March 29, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29587271/iterative-variance-stabilizing-transformation-denoising-of-spectral-domain-optical-coherence-tomography-images-applied-to-retinoblastoma
#12
Soumia Sid Ahmed, Zoubeida Messali, Florent Poyer, Livia Lumbroso-Le Rouic, Laurence Desjardins, Nathalie Cassoux, Carole D Thomas, Sergio Marco, Stéphanie Lemaitre
BACKGROUND: Due to the presence of speckle Poisson noise, the interpretation of spectral domain-optical coherence tomography (SD-OCT) images frequently requires the use of data averaging to improve the signal-to-noise ratio. This implies long acquisition times and requires patient sedation in some cases. Iterative variance stabilizing transformation (VST) is a possible approach by which to remove speckle Poisson noise on single images. METHODS: We used SD-OCT images of human and murine (LH Beta-Tag mouse model) retinas with and without retinoblastoma acquired with 2 different imaging devices (Bioptigen and Micron IV)...
March 26, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29566387/spectral-domain-optical-coherence-tomography-driven-treat-and-extend-and-pro-re-nata-regimen-in-patients-with-macular-oedema-due-to-retinal-vein-occlusion-24-month-evaluation-and-outcome-predictors
#13
Maria-Magdalena Guichard, Anton R Xavier, Cengiz Türksever, Christian Pruente, Katja Hatz
PURPOSE: To analyse the efficacy and outcome predictors of ranibizumab using a spectral-domain optical coherence tomography (SD-OCT)-driven treat-and-extend regimen (TER) versus SD-OCT-driven pro re nata regimen (PRN) in patients with cystoid macular oedema (CME) due to branch or central retinal vein occlusion (BRVO, CRVO). METHODS: Retrospective, consecutive case series. Evaluation included best corrected visual acuity (BCVA), morphological parameters on SD-OCT, and treatment frequency...
March 22, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29533959/efficacy-and-safety-of-bevacizumab-combined-with-mitomycin-c-or-5-fluorouracil-in-primary-trabeculectomy-a-meta-analysis-of-randomized-clinical-trials
#14
Hung-Ju Chen, Chin Lin, Cho-Hao Lee, Yi-Hao Chen
AIM: The objective of this study was to evaluate the efficacy and safety of bevacizumab combined with antimetabolite as an adjunctive therapy in primary trabeculectomy for glaucoma. MATERIALS AND METHODS: PubMed, Cochrane Library, and EMBASE were searched for relevant randomized controlled trials. Efficacy was evaluated by the postoperative mean intraocular pressure (IOP), complete success, and qualified success rates. Safety was evaluated by postoperative complications and surgical interventions...
2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29533953/tissue-plasminogen-activator-as-an-antiangiogenic-agent-in-experimental-corneal-neovascularization-in-rabbits
#15
Kon-Ichi Arai, Tsutomu Yasukawa, Aki Kato, Ayae Kubota, Hideaki Usui, Noriaki Takase, Soichiro Kuwayama, Yuichiro Ogura
AIMS: Anti-vascular endothelial growth factor agents effectively treat age-related macular degeneration and myopic choroidal neovascularization (CNV). Tissue plasminogen activator (tPA), a fibrinolytic compound, is used as an adjuvant to displace submacular hemorrhage and to treat type 2 CNV. The purpose of this study was to investigate in in vitro and in vivo experiments the antiangiogenic impact of tPA itself. METHODS: The impact of tPA on the proliferation of human umbilical vein endothelial cells (HUVECs) was assessed by an XTT assay [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide]...
2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29510401/subclinical-macular-edema-as-a-predictor-of-progression-to-central-involved-macular-edema-in-type-2-diabetes
#16
Conceição Lobo, Isabel Pires, Dalila Alves, Rajeev Pappuru, Luísa Ribeiro, José Cunha-Vaz
PURPOSE: The aim of this study was to examine the relationship between subclinical diabetic macular edema (SCME) and the development of central-involved macular edema (CIME) in patients with diabetes mellitus type-2 and mild nonproliferative diabetic retinopathy (NPDR), from 2 populations of different ethnicities. METHODS: Two hundred and five patients with diabetes mellitus type-2 and mild NPDR with no prior laser or intravitreal treatment were followed for 2 years or until the development of CIME...
March 6, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29421813/repeatability-and-reproducibility-of-foveal-avascular-zone-area-measurement-on-normal-eyes-by-different-optical-coherence-tomography-angiography-instruments
#17
Elisabetta Pilotto, Luisa Frizziero, Anna Crepaldi, Enrico Della Dora, Davide Deganello, Evelyn Longhin, Enrica Convento, Raffaele Parrozzani, Edoardo Midena
PURPOSE: To compare the foveal avascular zone (FAZ) area measurements produced by different optical coherence tomography angiography (OCTA). METHODS: Healthy enrolled volunteers underwent OCTA using 2 different devices: Spectralis HRA+OCTA (Heidelberg Engineering, Heidelberg, Germany) and RS-3000 Advance (Nidek, Gamagori, Japan). Two graders measured FAZ in both superficial (SCP) and deep (DCP) retinal capillary plexuses. The SCP and DCP en face images were visualized automatically segmenting 2 separate slabs defined by the arbitrary segmentation lines created by the software of each OCT device...
February 8, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29414835/choroidal-thickness-with-swept-source-optical-coherence-tomography-versus-foveal-morphology-in-young-children-with-a-history-of-prematurity
#18
Wadim Bowl, Marianne Bowl, Silke Schweinfurth, Kerstin Holve, Monika Andrassi-Darida, Knut Stieger, Birgit Lorenz
AIM: Comparison of choroidal thickness (CT) and foveal morphology as seen with swept-source optical coherence tomography (SS-OCT) in children with a history of treated or spontaneously regressed retinopathy of prematurity (tROP or srROP) to assess the impact on best-corrected visual acuity (BCVA). METHODS: CT was measured by SS-OCT (DRI-OCT Triton; Topcon, USA) single scans of a 6-mm diameter around the fovea in 17 children with tROP or srROP (4-7 years of age) and compared to 25 controls (age-matched children and adults)...
February 7, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29393247/optical-coherence-tomography-based-angiography-in-retinal-artery-occlusion-in-children
#19
Wojciech Hautz, Joanna Gołębiewska, Agnieszka Czeszyk-Piotrowicz
PURPOSE: To evaluate the role of optical coherence tomography (OCT)-based angiography (OCTA) in the diagnosis and monitoring of pediatric patients with retinal artery occlusion (RAO). MATERIAL AND METHODS: This retrospective study was conducted at the Department of Ophthalmology, The Children's Memorial Health Institute, in Warsaw between March 2015 and May 2016. Every patient underwent a complete ophthalmological examination. The diagnosis of the disease was based on fundus examination and fluorescein angiography (FA)...
January 24, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29339646/automated-screening-for-diabetic-retinopathy-a-systematic-review
#20
Mads Fonager Nørgaard, Jakob Grauslund
PURPOSE: Worldwide ophthalmologists are challenged by the rapid rise in the prevalence of diabetes. Diabetic retinopathy (DR) is the most common complication in diabetes, and possible consequences range from mild visual impairment to blindness. Repetitive screening for DR is cost-effective, but it is also a costly and strenuous affair. Several studies have examined the application of automated image analysis to solve this problem. Large populations are needed to assess the efficacy of such programs, and a standardized and rigorous methodology is important to give an indication of system performance in actual clinical settings...
January 16, 2018: Ophthalmic Research
journal
journal
22675
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"