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Ophthalmic Research

Xiangxi Chen, Xinxing Guo, Xiaoyu Xu, Hui Xiao, Xing Liu
PURPOSE: The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS: In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patient was diagnosed with PACG initially and later with MG after trabeculectomy, and the fellow eyes were diagnosed with PACG, PAC, or PAC suspect. Thirty-seven eyes from 37 PACG patients were recruited as controls...
September 5, 2018: Ophthalmic Research
Giovanni Cennamo, Maria Angelica Breve, Nunzio Velotti, Federica Sparnelli, Claudio Iovino, Antonio Farella, Raffaele Liuzzi, Giuseppe de Crecchio, Gilda Cennamo
AIM: The purpose of this paper was to evaluate whether optical coherence tomography angiography (OCT-A) can be used to quantify the vascular changes in radiation maculopathy, and changes in the tumor vasculature in eyes treated with plaque radiotherapy for choroidal melanoma. METHODS: In this prospective study, we evaluated 39 Caucasian patients with choroidal melanoma (39 eyes) treated with ruthenium-106 plaque radiotherapy. The patients underwent complete ophthalmic examination, bulbar echography, and OCT-A before and 1 year after treatment...
August 17, 2018: Ophthalmic Research
Rupert W Strauss, Beatriz Muñoz, Mohamed I Ahmed, Millena Bittencourt, Etienne M Schönbach, Michel Michaelides, David Birch, Eberhart Zrenner, Ann-Margret Ervin, Peter Charbel Issa, Jun Kong, Yulia Wolfson, Mahmood Shah, Saghar Bagheri, Sheila West, Hendrik P N Scholl
BACKGROUND/AIMS: To describe the design and baseline characteristics of patients enrolled in the multicenter, prospective natural history study of Stargardt disease type 4. METHODS: Fifteen eligible patients aged 6 years and older at baseline, harboring disease-causing variants in the PROM1 gene, and with specified ocular lesions were enrolled. They were examined at baseline using a standard protocol, with 6 monthly follow-up visits for a 2-year period including best-corrected ETDRS visual acuity, spectral-domain optical coherence tomography, fundus autofluorescence (FAF), mesopic and scotopic microperimetry (MP)...
August 15, 2018: Ophthalmic Research
Fabiana D'Esposito, Gilda Cennamo, Giuseppe de Crecchio, Paolo Enrico Maltese, Stefano Cecchin, Matteo Bertelli, Lucia Ziccardi, Paolo Esposito Veneruso, Adriano Magli, Giovanni Cennamo, Maria Francesca Cordeiro
AIM: To characterize by multimodal approach the phenotype of patients from a 3 generations pedigree, affected by autosomal dominant cone-rod dystrophy (CRD), found to carry a novel pathogenic variant in the cone-rod homeobox-containing (CRX) gene. METHODS: Examination of the adult patients included the following tests: visual acuity, multicolour imaging, spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and OCT angiography (OCT-A) recordings...
August 3, 2018: Ophthalmic Research
Hatem Zayed, Ussama M Abdel Motal, Akila Gopalakrishnan, Chinnayan Ponnuraja, C George Priya Doss, Nasser Rizk, Fatma M Shebl
AIMS: To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. METHODS: We systematically searched 4 different literature databases (PubMed, Science Direct, Web of Science and Embase), from the date of inception until December 2017, to collect all the information about patients with T1D who developed retinopathy complications; for statistical analysis, we used MetaXL to evaluate the pooled prevalence estimate and the subgroup prevalence estimates employing double arcsine transformation and inverse variance heterogeneity models...
July 25, 2018: Ophthalmic Research
Teresa Rolle, Laura Dallorto, Marco Tavassoli, Raffaele Nuzzi
PURPOSE: To evaluate papillary, peripapillary, and macular vasculature with optical coherence tomography angiography in preperimetric (PPG), primary open-angle glaucoma (POAG), and normal eyes, and to assess diagnostic ability and associations among the vasculature and structural damage. METHODS: This was an observational, cross-sectional study. Retinal nerve fiber layer (RNFL), ganglion cell complex thickness, whole-image (wiVD), inside disc (idVD), peripapillary (ppVD), and macular vessel densities were obtained...
June 28, 2018: Ophthalmic Research
Rupert W Strauss, Xiangrong Kong, Millena G Bittencourt, Alexander Ho, Anamika Jha, Etienne M Schönbach, Mohamed I Ahmed, Beatriz Muñoz, Ann-Margret Ervin, Michel Michaelides, David G Birch, José-Alain Sahel, Janet S Sunness, Eberhart Zrenner, Saghar Bagheri, Michael Ip, SriniVas Sadda, Sheila West, Hendrik P N Scholl
PURPOSE: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. METHODS: Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF)...
June 25, 2018: Ophthalmic Research
Christoph Leisser, Stefan Palkovits, Nino Hirnschall, Marlies Ullrich, Julius Hienert, Hannah Zwickl, Stefan Georgiev, Oliver Findl
PURPOSE: Internal limiting membrane (ILM) flap transposition in surgical repair of macular holes represents a new technique offering good anatomical success rates with large macular holes. The aim of the study was to examine microperimetric outcomes 1 year after ILM flap transposition for surgical repair of macular holes. METHODS: Patients with idi-opathic macular holes scheduled for 23-G pars plana vitrectomy with ILM peeling, ILM flap transposition, and SF6 tamponade were examined in a prospective case series...
June 22, 2018: Ophthalmic Research
Hyun-Kyung Cho, Min Gyu Lee, Changwon Kee
PURPOSE: This study aimed to investigate the association of the frequency of optic disk hemorrhage (DH) and progression of normal tension glaucoma (NTG) between each group based on the location of the initial retinal nerve fiber layer (RNFL) defect. METHODS: In this retrospective, observational cohort study, 142 NTG patients who underwent more than 5 reliable visual field tests with initial superior hemifield (group 2, n = 51), inferior hemifield (group 1, n = 44), or both hemifield (group 3, n = 47) defects were included...
June 12, 2018: Ophthalmic Research
Qing Peng, Yutong Chen, Rui Hua
AIM: To establish a novel retinal angiography method, red-free angiography (RFA), to investigate retinal changes in age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). METHODS: Following the venous phase of fundus fluorescein angiography (FFA), the detection mode was switched to red-free reflectance to acquire RFA images using the same parameters. RESULTS: RFA showed subretinal fluid, polyps, and outer retinal tubulation, with a higher definition than the FFA and red-free reflectance results...
June 7, 2018: Ophthalmic Research
Philipp Simon Koelbl, Jens Ulrich Werner, Christian Enders, Christian Lingenfelder, Frank H J Koch, Martin Hessling
PURPOSE: Surgical or diagnostic procedures are often accompanied by a short-term increase in intraocular pressure (IOP). A short-term increase in IOP can occur during refractive procedures, vitreoretinal surgery, transillumination, photocoagulation, or cryocoagulation. A porcine eye model was chosen (n = 89) to compile comparable study data and to de termine correlations between the force induced and the resulting intraocular pressure while excluding the effect of surgeons. METHODS: The IOP was measured in the anterior chamber...
May 31, 2018: Ophthalmic Research
Osamu Kotake, Hidetaka Noma, Kanako Yasuda, Ryosuke Motohashi, Hiroshi Goto, Masahiko Shimura
PURPOSE: To investigate dynamic changes in aqueous humor levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and inflammatory factors in patients receiving intravitreal ranibizumab injection (IRI) or intravitreal aflibercept injection (IAI) to treat central retinal vein occlusion (CRVO) with macular edema. METHODS: In 22 CRVO patients scheduled to receive 3 doses of ranibizumab (11 eyes) or aflibercept (11 eyes) at monthly intervals, aqueous samples were collected at the time of intravitreal injection...
May 25, 2018: Ophthalmic Research
Lukas Van Melkebeke, João Barbosa-Breda, Marc Huygens, Ingeborg Stalmans
BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking...
May 24, 2018: Ophthalmic Research
Chun Ding, Shengguo Li, Jun Zeng
PURPOSE: The aim of this study was to demonstrate the surgical technique and clinical outcome of autologous neurosensory retinal patch transplantation for recurrent large macular hole (MH)-induced retinal detachment after failed surgery with internal limiting membrane (ILM) removal or transplantation. METHODS: We reviewed 5 patients with recurrent MH-induced retinal detachment after failed surgeries with ILM removal or transplantation who underwent vitrectomy combined with autologous neurosensory retinal patch transplantations and were followed up over 6 months...
May 22, 2018: Ophthalmic Research
Yusuke Yasuda, Yoshio Hirano, Yuya Esaki, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To evaluate the location of microvascular abnormalities using wide-field fluorescein angiography (WFFA) and investigate the impact on visual outcome in eyes with branch retinal vein occlusion (BRVO). METHODS: Forty eyes of 39 patients (24 males and 15 females with an average age of 71 years) were retrospectively reviewed. One patient had BRVO bilaterally. WFFA was performed in all patients to evaluate perfusion status and detect microvascular abnormalities...
May 22, 2018: Ophthalmic Research
Giuseppe Giannaccare, Aldo Vagge, Stefano Sebastiani, Lara E Urbini, Paolo Corazza, Marco Pellegrini, Luciana Carmassi, Fulvio Bergamini, Carlo E Traverso, Emilio C Campos
PURPOSE: The aim of this study was to evaluate the safety and efficacy of ultrasound cyclo-plasty (UCP) for reducing intraocular pressure (IOP) in patients with glaucoma. METHODS: This is a multicentre prospective study conducted in 3 Italian glaucoma centres. UCP was performed by EyeOP1, which delivers ultrasound beams using 6 piezoelectric transducers activated for 4/6 s (first generation) or 8 s (second generation). Primary outcomes were the mean IOP reduction and the rates of success after 1 year...
May 16, 2018: Ophthalmic Research
Huiyuan Hou, Eric Nudleman, Robert N Weinreb
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.
May 3, 2018: Ophthalmic Research
Wen Lin, Guoxing Xu
Autophagy is a lysosomal degradation process that maintains cellular homeostasis by removing dysfunctional organelles and unfolded proteins. Increasing evidence has shown that autophagy proteins are involved in retinal physiology and pathology and that defective autophagy contributes to retinal degeneration. In retinal diseases, autophagy plays a dual role: promoting retinal cell survival and death. Autophagy at a normal level helps retinal cells defend themselves against harmful stress; however, excessive autophagy results in retinal deterioration...
April 25, 2018: Ophthalmic Research
Xiao Na Wang, Qi Sheng You, Qian Li, Yang Li, Yu Mao, Feng Hu, Hui Ying Zhao, Frank F Tsai, Xiao Yan Peng
PURPOSE: To evaluate the vascular anatomy of eyes with Best vitelliform macular dystrophy (BVMD) using optical coherence tomography angiography (OCTA). METHODS: This retrospective case-control study enrolled 11 consecutive BVMD patients and 13 age-matched healthy participants. Both eyes of each participant were imaged using a macular OCTA scan (3 × 3 mm) by 70-kHz 840-nm spectral-domain OCT. The flow signal was calculated using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm...
April 13, 2018: Ophthalmic Research
Jia-Jia Yuan, Yong Zhang, Li-Ling Wang, Ming-Shi Cheng, Si-Qi Ma, Qin Gao, Bin Li
PURPOSE: To assess changes in visual field (VF) values after gene therapy for Leber's hereditary optic neuropathy (LHON). METHODS: VF recovery, VF indices, and mean deviation in injected and uninjected eyes, before and after gene therapy, were examined in 2 groups of patients according to disease duration (≤2 years and > 2 years). Nine patients with LHON were treated by monocular intravitreal injection of AAV2-ND4. Finally, 7 patients were considered for subsequent comparisons; the first and second eyes were treated separately...
April 12, 2018: Ophthalmic Research
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