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Ophthalmic Research

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December 1, 2016: Ophthalmic Research
Sang-Il Park, Young Pyo Jang
A2E-laden ARPE-19 cells were exposed to a blue light to induce cytotoxicity, in order to investigate the protective effects of various tinted ophthalmic lenses against photo-induced cytotoxicity in human retinal pigment epithelial (RPE) cells laden with A2E, known to be among the etiologies of age-related macular degeneration (AMD). Different-colored tinted lenses with varying levels of tint and different filtering characteristics, such as polarized, blue-cut, and photochromatic lenses, were placed over the cells, and the protective efficacies thereof were evaluated by lactate dehydrogenase assay...
November 24, 2016: Ophthalmic Research
Frank G Holz, Ramin Tadayoni, Stephen Beatty, Alan R Berger, Matteo G Cereda, Philip Hykin, Carel B Hoyng, Kim Wittrup-Jensen, Andreas Altemark, Jonas Nilsson, Kun Kim, Sobha Sivaprasad
OBJECTIVE: AURA was an observational study that monitored visual acuity outcomes following ranibizumab use in neovascular age-related macular degeneration patients over 2 years. The aim of this analysis was to identify factors that were predictive of visual acuity outcomes in AURA. METHODS: The correlation between the baseline characteristics, the use of resources and the visual acuity outcomes in AURA was explored using principal component analysis (PCA) and partial least-squares-discriminant analysis (PLS-DA)...
November 11, 2016: Ophthalmic Research
Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
Shumpei Obata, Masato Fujikawa, Keisuke Iwasaki, Masashi Kakinoki, Osamu Sawada, Yoshitsugu Saishin, Hajime Kawamura, Masahito Ohji
PURPOSE: To investigate anatomic changes in retinal thickness (RT) and functional changes after vitrectomy for idiopathic epiretinal membranes (ERMs) with and without internal limiting membrane (ILM) peeling. METHODS: The medical records of 100 eyes of 96 patients with ERM who underwent vitrectomy and ERM removal were reviewed retrospectively. The RT was measured by optical coherence tomography, and the area was divided into 9 sections. The best-corrected visual acuity (BCVA), 9 RT areas, and incidence rates of recurrent ERM were compared between the groups with and without ILM peeling before the operation and 12 months postoperatively...
October 20, 2016: Ophthalmic Research
Natàlia Vilà, Jacqueline Coblentz, Carlos Moreira-Neto, Vasco Bravo-Filho, Pablo Zoroquiain, Miguel N Burnier
PURPOSE: To determine whether pretreatment of retinal pigmented epithelial (RPE) cells with lutein can affect the response of cells to bevacizumab therapy. METHODS: One human RPE cell line (ARPE-19) was used for all experiments. The cells were treated with lutein in different concentrations (0.01, 0.1, 1, 10, or 100 μg/ml). After 24 h, all plates were treated with bevacizumab (0.25 mg/ml). Media were harvested 24 h later for sandwich ELISA-based angiogenesis arrays...
October 15, 2016: Ophthalmic Research
Ko Un Shin, Su Jeong Song, Jeong Hun Bae, Mi Yeon Lee
AIMS: The aim of this paper was to develop a risk prediction model for the progression of age-related macular degeneration (AMD) in Koreans using systemic and environmental factors. METHODS: The study sample included 10,890 individuals 50 years of age or older; 318 (2.92%) presented with early AMD findings in baseline examinations. Re-examinations were performed in 157 (49.37%) who were followed up for 4.4 years. The multivariate analysis of covariates included demographic and environmental factors...
October 13, 2016: Ophthalmic Research
Cem Ozgonul, Cagri Giray Besirli
Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised patients, may create diagnostic challenges and lead to misdiagnosis and inappropriate treatment. Molecular biology techniques to diagnose ocular toxoplasmosis have been available for many years and are now accessible as standard laboratory tests in many countries...
October 11, 2016: Ophthalmic Research
Pierluigi Iacono, Maurizio Battaglia Parodi, Francesco Bandello
AIM: Evaluation of the proportion of patients affected by subfoveal choroidal neovascularization secondary to age-related macular degeneration who are non-respondent to intravitreal ranibizumab injections (IVRI). METHODS: Patients received 3 monthly IVRI, with monthly retreatments, in accordance with a pro re nata scheme (fluid on optical coherence tomography, leakage on fluorescein angiography, new haemorrhages). Non-responders were classified as follows: functional non-responder (best-corrected visual acuity worsening by a minimum of 2 ETDRS lines); anatomical non-responder (central foveal thickness not decreasing by at least 10% compared with baseline value); complete non-responder (both anatomical and functional non-responder criteria apply)...
October 1, 2016: Ophthalmic Research
Jie Lan, Dapeng Sun, Khatoon Alabdulrasool, Hassan Ebrahim Yusuf, Lu Zhang
BACKGROUND: The aim of this work was to evaluate the narrow anterior chamber angle (ACA) in Chinese patients by anterior segment optical coherence tomography (As-OCT). METHODS: Eighty right eyes of 80 consecutive patients with a shallow peripheral anterior chamber but no peripheral anterior synechia were enrolled in this study. The ACA was observed by noncompression gonioscopy and classified according to the Shaffer grading system. The iridotrabecular contact (ITC) and trabecular-iris angle (T-I angle) were assessed by As-OCT examination...
September 15, 2016: Ophthalmic Research
Asaf Achiron, Ayana Kydyrbaeva, Vitaly Man, Oded Lagstein, Zvia Burgansky, Oren Blumenfeld, Asaf Bar, Elisha Bartov
PURPOSE: Assessing changes in foveal photoreceptor microstructure (FPM) following intravitreal anti-VEGF treatment may serve as a prognostic marker in patients with macular edema (ME). METHODS: Sixteen eyes belonging to newly diagnosed patients with ME were included in this prospective longitudinal study. FPM integrity was evaluated at baseline and at the end of a series of anti-VEGF injections. RESULTS: Treatment led to a significant improvement in mean visual acuity (VA) and central macular thickness...
September 15, 2016: Ophthalmic Research
Inês Dinis Aires, António Francisco Ambrósio, Ana Raquel Santiago
Glaucoma, a leading cause of blindness worldwide, is a degenerative disease characterized by retinal ganglion cell (RGC) loss and optic nerve atrophy. Elevated intraocular pressure (IOP) is a main risk factor for onset and progression of the disease. Since increased IOP is the only modifiable risk factor, relevant models for glaucoma would comprise RGC and optic nerve damage triggered by ocular hypertension. Animal models of glaucoma have greatly contributed to the understanding of the molecular mechanisms of this pathology, and they have also facilitated the development of new pharmacological interventions...
September 13, 2016: Ophthalmic Research
Ghulam Mohammad, Deema Jomar, Mohammad Mairaj Siddiquei, Kaiser Alam, Ahmed M Abu El-Asrar
PURPOSE: The expression of high-mobility group box-1 (HMGB1) and signal transducer and activator of transcription-3 (STAT-3) is upregulated in the diabetic retina. We hypothesized that the activation of STAT-3 is under the control of HMGB1. METHODS: Retinas from 1-month-old diabetic rats and from normal rats intravitreally injected with HMGB1 and human retinal Müller glial cells (MIO-M1) stimulated with HMGB1 or high glucose were studied by Western blot analysis and immunofluorescence...
August 25, 2016: Ophthalmic Research
Qian Xing, Guowei Zhang, Lihua Kang, Jian Wu, Hui Chen, Gaoqin Liu, Rongrong Zhu, Huaijin Guan, Peirong Lu
BACKGROUND: Diabetic retinopathy (DR) is a severe ocular complication of diabetes. Kallistatin has multiple biological functions including anti-inflammation and antiangiogenesis. Our aim was to detect the level of kallistatin in the vitreous of proliferative DR (PDR) and its effect on proliferation, migration, and tube formation of human retinal endothelial cells (HRECs) under high glucose in an in vitro model. METHODS: Vitreous humor samples were obtained through pars plana vitrectomy from 7 nondiabetic patients with idiopathic macular holes or idiopathic preretinal membranes and 10 PDR patients...
August 19, 2016: Ophthalmic Research
Koen Willekens, Sophie Bataillie, Inge Sarens, Sofie Odent, Luìs Abegão Pinto, Evelien Vandewalle, Karel Van Keer, Ingeborg Stalmans
PURPOSE: To compare funduscopic and confocal scanning vertical cup-disc ratio (VCDR) assessments and their respective predictive value for estimating functional glaucomatous damage. METHODS: Data from a single eye of open angle glaucoma patients from the Leuven Eye Study were included: age, gender, intra-ocular pressure, visual acuity, refractive error, visual field mean deviation and pattern standard deviation, funduscopic and HRT III VCDRs as well as mean retinal nerve fibre layer thickness...
August 4, 2016: Ophthalmic Research
Irini Chatziralli, George Theodossiadis, Ioannis Datseris, Efstratios Parikakis, Panagiotis Theodossiadis
PURPOSE: The purpose of this study was to evaluate the anatomical and functional findings in patients with vitreomacular traction (VMT) combined with epiretinal membrane (ERM) in the same eye. METHODS: In this retrospective, cross-sectional study, we studied 65 patients with VMT and ERM. In 36 of them, ERM/VMT had a 'unified' appearance (group x0399;) but in 29, VMT and ERM coexisted without an interrelationship (group x0399;x0399;). All patients were examined with spectral-domain optical coherence tomography (SD-OCT)...
July 16, 2016: Ophthalmic Research
Carlos Alves, Inês Ribeiro, Ana Penedones, Diogo Mendes, Francisco Batel Marques
OBJECTIVES: This meta-analysis aims to evaluate the risk of ophthalmic adverse effects associated with MEK inhibitors. METHODS: A literature search was conducted in PubMed and the Cochrane Library to identify randomized clinical trials (RCTs) which have been designed to evaluate the efficacy and safety of MEK inhibitors. Overall risk of ophthalmic adverse effects, chorioretinopathy, retinal detachment, blurred vision, uveitis, and eye haemorrhage were the assessed outcomes...
July 13, 2016: Ophthalmic Research
Hülya Yazıcı, Gökhan Gürelik, Fulya Yaylacıoğlu Tuncay, Pınar Uyar Göçün
PURPOSE: To examine whether ciliary body transplantation is applicable, the graft is viable and the localization of the graft material affects graft survival. METHODS: Fifteen female New Zealand white rabbits were used. Three of them were used as donors, and a ciliary body graft was prepared from their enucleated eyes. There are two groups in the study according to the localization of the ciliary body graft in the anterior chamber. The graft was placed on the iris surface close to the pupil margin in group 1 and adjacent to the anterior chamber angle in group 2...
July 8, 2016: Ophthalmic Research
Jesús Merayo-Lloves, Ronald M Sanchez-Avila, Ana C Riestra, Eduardo Anitua, Leire Begoña, Gorka Orive, Luis Fernandez-Vega
PURPOSE: To provide preliminary information about the safety and efficacy of plasma rich in growth factors (PRGF) in the treatment of evaporative dry eye (EDE) and analyze the influence of certain variables on treatment outcomes. METHODS: This retrospective study included patients with EDE treated between January 2011 and December 2013. Outcome measures including signs and symptoms of the disease were evaluated before and after treatment. The influence of some of the patient's clinical variables on results was assessed...
July 2016: Ophthalmic Research
Ji-Guo Yu, Zhong-Ming Mei, Ting Ye, Yi-Fan Feng, Fang Zhao, Jun Jia, Xun-An Fu, Yi Xiang
PURPOSE: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS: The Cochrane Library, Medline, and Embase were screened using our key words. Results were carefully reviewed to ensure that the included studies met the inclusion/exclusion criteria, and the quality of the studies was assessed using the Newcastle-Ottawa Scale. All included studies categorized patients with OSAHS into 3 groups (mild, moderate, and severe), and measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness...
July 2016: Ophthalmic Research
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