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Ophthalmic Research

Kiyeun Nam, Hyun Jung Kim, Aeri Yoo
PURPOSE: A meta-analysis was performed to evaluate the safety and efficacy of topical 3% diquafosol in treating patients with dry eye disease (DED). METHODS: Nine qualified randomized controlled trials incorporating 1,467 patients were included. Two of the reviewers selected the studies and independently assessed the risk of bias. The outcome measures were Schirmer score, tear film break-up time (TFBUT), rose bengal staining score, and corneal fluorescein staining score...
January 17, 2019: Ophthalmic Research
Hendrik P N Scholl
No abstract text is available yet for this article.
January 9, 2019: Ophthalmic Research
Rino Frisina, Elisabetta Pilotto, Edoardo Midena
Lamellar macular hole (LMH) is a vitreoretinal disorder characterized by an irregular foveal contour, a break in the inner fovea, dehiscence of the inner foveal retina from the outer retina, and the absence of a full-thickness foveal defect with intact foveal photoreceptors. The pathogenesis is only partially known. The advent of high-resolution optical coherence tomography has allowed distinguishing between two types of epiretinal membrane (ERM) associated with LMH: a conventional ERM (commonly found in macular pucker) and an atypical ERM (known by varied names: dense, epiretinal proliferation, or degenerative)...
January 9, 2019: Ophthalmic Research
Rossella D'Aloisio, Rosa Giglio, Marta Di Nicola, Chiara De Giacinto, Marco Rocco Pastore, Daniele Tognetto, Tunde Peto
BACKGROUND: Digital retinal imaging is the gold standard technique for diabetic retinopathy (DR) and diabetic macular oedema (DME) assessment during DR screening. OBJECTIVES: To evaluate the diagnostic accuracy of digital retinal fundus image (DRFI) analysis in detecting DME using three manual grading systems (MGS) and comparing it with optical coherence tomography (OCT) findings. METHOD: A total of 287 DRFI of 287 eyes were analysed. Non-stereoscopic 45° images were acquired using a Kowa VX-20 camera and were graded according to three MGS: Early Treatment Diabetic Retinopathy Study (ETDRS), International Clinical Diabetic Retinopathy (ICDR), and United Kingdom National Screening Committee (UKNSC)...
December 14, 2018: Ophthalmic Research
Xi Wang, Xiaohang Chen, Longqian Liu
PURPOSE: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. The angle of deviation, success rates, near stereopsis, and surgical effect of BLR were evaluated. Surgical success was defined as postoperative deviations ≤10 prism diopters (PD)...
December 6, 2018: Ophthalmic Research
Pradeep Venkatesh, Brijesh Takkar
Retinal angiomas are rare tumors that develop within the vascular bed of the retina. Their occurrence may be sporadic or as part of the multisystem disorder called von Hippel-Lindau disease. It is well established in literature that retinal angiomas have a natural history of evolving as small aneurysmal dilatations and progressing to vision-threatening retinal detachments. Several approaches to the management of these angiomas have been reported in the literature, but it is difficult to decipher which modality is best suited for which type of angioma...
November 29, 2018: Ophthalmic Research
Bernardete Pessoa, David Afonso Dias, Pedro Baptista, Constança Coelho, João Nuno Melo Beirão, Angelina Meireles
PURPOSE: To evaluate pars plana vitrectomy (PPV) outcomes in cases with tractional diabetic macular edema (tDME). METHODS: We conducted a single-center retrospective study with a follow-up of 12 months. Forty-six eyes with tDME of 38 patients submitted to PPV between 2013 and 2015 were assessed. A standard PPV was performed and surgical outcomes were registered at the 3-, 6-, and 12-month follow-up. RESULTS: The baseline median best corrected visual acuity (BCVA) in ETDRS (Early Treatment Diabetic Retinopathy Study) letters and the median central foveal thickness (CFT) were 43...
November 23, 2018: Ophthalmic Research
Sachin S Thakur, Darshan Shrestha, Ilva D Rupenthal
The use of corneal tissue for ex vivo therapeutic evaluations is limited due to its rapid loss of viability after excision. Optimization of storage conditions may allow prolonged retention of physical tissue properties. In this study, we evaluated how storage in optimized organ culture (OC) medium at 37°C or phosphate-buffered saline (PBS) at 2-8°C impacted physical properties of bovine corneas. Tissue hydration, permeability and histology were monitored at baseline and following 1, 4 and 7 days of storage...
November 22, 2018: Ophthalmic Research
Prisca Loganadane, Bernard Delbosc, Maher Saleh
PURPOSE: To assess the progression of diabetic hard exudates over an 8-week period, using a high-resolution adaptive optics camera. DESIGN: Prospective observational study. METHODS: Five eyes of three patients presenting diabetic maculopathy with hard exudates were studied. An area of clinically visible exudates was imaged sequentially using SD-OCT and high-resolution flood illumination adaptive optics for 2 months, on a weekly basis. A time-lapse video was obtained for each eye studied...
November 22, 2018: Ophthalmic Research
Jeremy Tan, Ute Vollmer-Conna, Lien Tat, Minas Coroneo
PURPOSE: The aim of this paper was to investigate the degree of inflammation and dry-eye disease (DED) in recurrent pterygium. METHODS: Fifty-five patients with a history of pterygium excision were divided into 3 groups - Group 1: no recurrence after the first excision; Group 2: recurrence after the first excision; Group 3: no recurrence after the second excision. Dry-eye symptoms and tear production were elicited for each patient. RESULTS: A high prevalence of DED was observed in patients with primary and recurrent pterygium based on self-reported dry-eye symptoms (63...
October 31, 2018: Ophthalmic Research
Taneto Tomiyasu, Yoshio Hirano, Norihiro Suzuki, Yuya Esaki, Yusuke Yasuda, Akiyoshi Uemura, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To study the structural and functional changes of retinal ischemia and investigate their association with macular edema (ME) or microaneurysm (MA) formation in eyes with retinal vein occlusion (RVO). METHODS: Sixty eyes of 30 patients (27 eyes with branch [b]RVO, 3 with central RVO, and 30 fellow eyes) were retrospectively reviewed. Optical coherence tomography (OCT), OCT angiography (OCTA), and microperimetry were performed simultaneously to measure retinal thickness and sensitivity...
October 25, 2018: Ophthalmic Research
Gilda Cennamo, Vittoria Lanni, Rosa Abbate, Nunzio Velotti, Federica Fossataro, Federica Sparnelli, Mario R Romano, Giuseppe de Crecchio, Giovanni Cennamo
AIM: Macular pigment density and microvascular density on optical coherence tomography angiography (OCTA) were measured in a cohort of type 1 diabetes mellitus (T1DM) patients with retinopathy in the attempt to shed light on the pathophysiology of this condition. METHODS: Eighty-two consecutive eyes of 59 patients with diabetic retinopathy examined at the Eye Clinic of the University of Naples Federico II from November 2016 to April 2017 were enrolled in this prospective study...
October 11, 2018: Ophthalmic Research
Takao Hirano, Yuichi Toriyama, Yasuhiro Iesato, Akihiro Ishibazawa, Masahiko Sugimoto, Yoshihiro Takamura, Taiji Nagaoka, Toshinori Murata
PURPOSE: Evaluate the effect of foveal leaking microaneurysms (MAs) on the required number of intravitreal ranibiz-umab (IVR) injections in the treatment of center-involving diabetic macular edema (DME) when treated with focal/grid laser. DESIGN: A pilot study of prospective, nonrandomized, multicenter clinical trial. METHODS: This study enrolled 21 eyes with DME for which pro re nata IVR injections were combined with short-pulse focal/grid laser...
October 10, 2018: Ophthalmic Research
Hatem Zayed, Ussama M Abdel Motal, Akila Gopalakrishnan, Chinnayan Ponnuraja, C George Priya Doss, Nasser Rizk, Fatma M Shebl
AIMS: To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. METHODS: We systematically searched 4 different literature databases (PubMed, Science Direct, Web of Science and Embase), from the date of inception until December 2017, to collect all the information about patients with T1D who developed retinopathy complications; for statistical analysis, we used MetaXL to evaluate the pooled prevalence estimate and the subgroup prevalence estimates employing double arcsine transformation and inverse variance heterogeneity models...
July 25, 2018: Ophthalmic Research
Teresa Rolle, Laura Dallorto, Marco Tavassoli, Raffaele Nuzzi
PURPOSE: To evaluate papillary, peripapillary, and macular vasculature with optical coherence tomography angiography in preperimetric (PPG), primary open-angle glaucoma (POAG), and normal eyes, and to assess diagnostic ability and associations among the vasculature and structural damage. METHODS: This was an observational, cross-sectional study. Retinal nerve fiber layer (RNFL), ganglion cell complex thickness, whole-image (wiVD), inside disc (idVD), peripapillary (ppVD), and macular vessel densities were obtained...
June 28, 2018: Ophthalmic Research
Rupert W Strauss, Xiangrong Kong, Millena G Bittencourt, Alexander Ho, Anamika Jha, Etienne M Schönbach, Mohamed I Ahmed, Beatriz Muñoz, Ann-Margret Ervin, Michel Michaelides, David G Birch, José-Alain Sahel, Janet S Sunness, Eberhart Zrenner, Saghar Bagheri, Michael Ip, SriniVas Sadda, Sheila West, Hendrik P N Scholl
PURPOSE: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. METHODS: Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF)...
June 25, 2018: Ophthalmic Research
Christoph Leisser, Stefan Palkovits, Nino Hirnschall, Marlies Ullrich, Julius Hienert, Hannah Zwickl, Stefan Georgiev, Oliver Findl
PURPOSE: Internal limiting membrane (ILM) flap transposition in surgical repair of macular holes represents a new technique offering good anatomical success rates with large macular holes. The aim of the study was to examine microperimetric outcomes 1 year after ILM flap transposition for surgical repair of macular holes. METHODS: Patients with idi-opathic macular holes scheduled for 23-G pars plana vitrectomy with ILM peeling, ILM flap transposition, and SF6 tamponade were examined in a prospective case series...
June 22, 2018: Ophthalmic Research
Qing Peng, Yutong Chen, Rui Hua
AIM: To establish a novel retinal angiography method, red-free angiography (RFA), to investigate retinal changes in age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). METHODS: Following the venous phase of fundus fluorescein angiography (FFA), the detection mode was switched to red-free reflectance to acquire RFA images using the same parameters. RESULTS: RFA showed subretinal fluid, polyps, and outer retinal tubulation, with a higher definition than the FFA and red-free reflectance results...
June 7, 2018: Ophthalmic Research
Philipp Simon Koelbl, Jens Ulrich Werner, Christian Enders, Christian Lingenfelder, Frank H J Koch, Martin Hessling
PURPOSE: Surgical or diagnostic procedures are often accompanied by a short-term increase in intraocular pressure (IOP). A short-term increase in IOP can occur during refractive procedures, vitreoretinal surgery, transillumination, photocoagulation, or cryocoagulation. A porcine eye model was chosen (n = 89) to compile comparable study data and to de termine correlations between the force induced and the resulting intraocular pressure while excluding the effect of surgeons. METHODS: The IOP was measured in the anterior chamber...
May 31, 2018: Ophthalmic Research
Osamu Kotake, Hidetaka Noma, Kanako Yasuda, Ryosuke Motohashi, Hiroshi Goto, Masahiko Shimura
PURPOSE: To investigate dynamic changes in aqueous humor levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and inflammatory factors in patients receiving intravitreal ranibizumab injection (IRI) or intravitreal aflibercept injection (IAI) to treat central retinal vein occlusion (CRVO) with macular edema. METHODS: In 22 CRVO patients scheduled to receive 3 doses of ranibizumab (11 eyes) or aflibercept (11 eyes) at monthly intervals, aqueous samples were collected at the time of intravitreal injection...
May 25, 2018: Ophthalmic Research
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