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American Journal of Medicine

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https://www.readbyqxmd.com/read/28647407/external-validation-of-the-simple-null-please-clinical-score-in-predicting-outcome-of-out-of-hospital-cardiac-arrest
#1
Tatjana S Potpara, Miroslav Mihajlovic, Sanja Stankovic, Tanja Jozic, Irena Jozic, Milika R Asanin, Rajai Ahmad, Gregory Y H Lip
BACKGROUND: Rapid clinical decision-making on further management of patients with out-of-hospital cardiac arrest may be challenging. Recently, a 'futility' score (NULL-PLEASE) incorporating multiple adverse resuscitation features (Non-shockable rhythm, Unwitnessed arrest, Long no-flow or Long low-flow period, blood pH <7.2, Lactate >7.0 mmol/l, End-stage chronic kidney disease on dialysis, Age ≥85 years, Still resuscitation and Extra-cardiac cause) has been proposed to help identify out-of-hospital cardiac arrest patients unlikely to survive; however, external independent score validation is lacking...
June 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28647406/unstable-angina-in-the-era-of-cardiac-troponin-assays-with-improved-sensitivity-a-clinical-dilemma
#2
K M Eggers, T Jernberg, B Lindahl
INTRODUCTION: There is an expectation that with the adoption of more sensitive cardiac troponin (cTn) assays, unstable angina would become a rarity. However, recent data from the SWEDEHEART registry demonstrated that 15% of patients admitted with non ST-elevation acute coronary syndrome (NSTE-ACS) still were regarded having unstable angina. We aimed to further investigate the clinical characteristics and outcome of these patients. METHODS: Retrospective registry-based analysis (SWEDEHEART) including 3204 unstable patients, 18,194 non ST-elevation myocardial infarction (NSTEMI) patients and 977 controls without acute cardiovascular disease...
June 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28625409/expectations-of-the-ideal-worker-and-its-influence-on-professional-identity-in-academic-medicine-perspectives-from-a-career-flexibility-educational-intervention
#3
Lydia Pleotis Howell, Laurel A Beckett, Amparo C Villablanca
• Career flexibility policies to support faculty work-life balance are under-utilized due to many perceived barriers. • Reported barriers to policy use increased after an educational intervention, reflecting conflicts with personal and professional identity and team/peer pressure. • Creating a culture that increases work-life flexibility and satisfaction requires addressing expectations for extreme work devotion, perhaps best accomplished by faculty roles models who can re-shape the "hidden curriculum" of medical education and training...
June 15, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28624541/the-high-prevalence-and-clinical-socio-demographic-correlates-of-miscarriages-among-flight-attendants
#4
Bettina Heidecker, Rachel Maureen Spencer, Victoria Hayes, Sarah Hall, Nisha Parikh, Eveline Oestreicher Stock, Rita Redberg
BACKGROUND: There are many occupational health hazards associated with long hours of air travel including cosmic radiation exposure, circadian rhythm disruptions and secondhand smoke exposure prior, for flight attendants who flew prior to smoking bans initiated in the 90s. Previous studies in flight attendants have found increased incidence of breast cancer and melanoma. However, there is little information on the relationship of airline travel and reproductive health in flight attendants...
June 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28623177/delay-in-diagnosis-of-celiac-disease-in-patients-without-gastrointestinal-complaints
#5
Marco A Paez, Anna Maria Gramelspacher, James Sinacore, Laura Winterfield, Mukund Venu
PURPOSE: The purpose of our study is to investigate the delay in diagnosis of patients with biopsy-proven celiac disease in those who present with gastrointestinal complaints vs non-gastrointestinal complaints at our tertiary care center. Celiac disease is an autoimmune disorder which affects approximately 1% of the population worldwide. Celiac disease can have variable clinical presentations characterized by either predominately gastrointestinal symptoms or may present without any gastrointestinal symptom...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28623176/duration-of-dual-anti-platelet-therapy-in-patients-with-an-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-controlled-trials
#6
Chirag Bavishi, Vrinda Trivedi, Mandeep Singh, Edward Katz, Franz H Messerli, Sripal Bangalore
BACKGROUND: The recent AHA/ACC guidelines on duration of dual anti-platelet therapy (DAPT) recommend DAPT for 1 year in patients presenting with an acute coronary syndrome, with a Class IIb recommendation for continuation. We aim to assess the evidence for these recommendations using a meta-analytic approach. METHODS: We searched electronic databases for randomized trials comparing short-term (≤6 months) vs 12 months vs extended (>12 months) DAPT in patients with an acute coronary syndrome undergoing percutaneous coronary intervention...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28623175/elevated-high-density-lipoprotein-cholesterol-is-associated-with-hyponatremia-in-hypertensive-patients
#7
Ariel Israel, Ehud Grossman
BACKGROUND: Recently, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive lowering of systolic blood pressure is beneficial, but is associated with more adverse events. Hyponatremia was notably more frequent in the intensive treatment group. Investigating its risk factors is crucial for preventing this complication. OBJECTIVE: To identify risk factors for hyponatremia in the adult population. METHODS: We investigated the baseline demographic, clinical and laboratory data from the 9,361 participants of SPRINT to identify the best predictors of hyponatremia (serum sodium ≤ 130mEq/L), and adverse events which could be attributed to hyponatremia, using machine learning and multivariable Cox proportional hazards models...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28623174/sex-differences-in-the-management-and-5-year-outcome-of-young-patients-55y-with-acute-coronary-syndromes
#8
Avi Sabbag, Shlomi Matetzky, Avital Porter, Zaza Iakobishvili, Mady Moriel, Donna Zwas, Paul Fefer, Elad Asher, Roy Beigel, Shmuel Gottlieb, Ilan Goldenberg, Amit Segev
BACKGROUND: Young women are usually protected against coronary artery disease due to hormonal and risk-factor profile. Previous studies have suggested poorer outcome in women hospitalized with acute coronary syndrome as compared to men. However, when adjusted to age and other risk factors, this difference does not remain significant. We compared the risk-profile and outcome between young (≤55) women and men admitted with acute coronary syndrome. METHODS: We analyzed clinical characteristics, management strategies, and outcomes of men and women ≤55y enrolled in the biennial Acute Coronary Syndrome Israeli Surveys (ACSIS) between 2000 and 2013...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28623173/outcomes-of-transcatheter-and-surgical-aortic-valve-replacement-in-patients-on-maintenance-dialysis
#9
Fahad Alqahtani, Sami Aljohani, Khaled Boobes, Elad Maor, Assem Sherieh, Charanjit S Rihal, David R Holmes, Mohamad Alkhouli
BACKGROUND: the introduction of transcatheter aortic valve replacement (TAVR) expanded definitive therapy of aortic stenosis to many high-risk patients, but it has not been fully evaluated in the dialysis population. OBJECTIVES: We aimed to evaluate the current trend and in-hospital outcome of Surgical aortic valve replacement (SAVR) and TAVR in the dialysis population. METHODS: Severe aortic stenosis patients on maintenance dialysis who underwent SAVR or TAVR in the Nationwide Inpatient Sample database (NIS) from January 1, 2005, through December 31, 2014, were included in our comparative analysis...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28623172/the-armadillo-factor-lepromatous-leprosy
#10
Laura C Cleary, Smitha Suraj, David Haburchak, Jake E Turrentine
No abstract text is available yet for this article.
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28606799/patterns-of-readmissions-for-three-common-conditions-among-younger-u-s-adults
#11
Devraj Sukul, Shashank S Sinha, Andrew M Ryan, Michael W Sjoding, Scott L Hummel, Brahmajee K Nallamothu
BACKGROUND: Thirty-day readmissions among elderly Medicare patients are an important hospital quality measure. Although plans for employing 30-day readmission measures are under consideration for younger patients, little is known about readmission in younger patients or the relationship between readmissions in younger and elderly patients at the same hospital. METHODS: Using the 2014 Nationwide Readmissions Database, we examined readmission patterns in younger patients (18- to 64-years-old) using hierarchical models to evaluate associations between hospital 30-day risk-standardized readmission rates (RSRRs) in elderly Medicare patients and readmission risk in younger patients with acute myocardial infarction, heart failure, or pneumonia...
June 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28606798/the-coronary-cardiac-care-unit-at-50-years-a-major-advance-in-the-practice-of-hospital-medicine
#12
EDITORIAL
William H Frishman, Joseph S Alpert, Thomas Killip
No abstract text is available yet for this article.
June 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28606797/do-factor-v-leiden-and-prothrombin-g20210a-mutations-predict-recurrent-venous-thromboembolism-in-older-patients
#13
Marie Méan, Andreas Limacher, Odile Stalder, Anne Angelillo-Scherrer, Lorenzo Alberio, Pierre Fontana, Hans-Jürg Beer, Nicolas Rodondi, Bernhard Lämmle, Drahomir Aujesky
BACKGROUND: The value of genetic thrombophilia testing in elderly patients with an unprovoked venous thromboembolism is unclear. We assessed whether the factor V Leiden and the prothrombin G20210A mutation are associated with recurrent venous thromboembolism in elderly patients in a prospective multicenter cohort study. METHODS: We genotyped the factor V Leiden and the prothrombin G20210A mutation in 354 consecutive in- and outpatients aged ≥65 years with a first unprovoked venous thromboembolism from nine Swiss hospitals...
June 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28606796/post-polio-like-syndrome
#14
Shingo Suzuki, Sonoko Misawa, Takahiro Ota, Yu Li, Satoshi Kuwabara, Masatomi Ikusaka
No abstract text is available yet for this article.
June 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28602877/platelet-count-of-zero-a-curious-case-of-thrombocytopenia
#15
Patrick Twohig, Jaclyn Rivington
No abstract text is available yet for this article.
June 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28602876/diagnosing-bilateral-tarsal-tunnel-syndrome
#16
Kohei Morinaga, Taro Shimizu
No abstract text is available yet for this article.
June 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28602875/trench-mouth
#17
Tanay Chaubal, Ranjeet Bapat
No abstract text is available yet for this article.
June 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28602874/intravenous-immunoglobulins-improve-survival-in-monoclonal-gammopathy-associated-systemic-capillary-leak-syndrome
#18
Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Jean-Christophe Lega, Marc Lambert, Sophie Rivière, Antoine Dossier, Marc Ruivard, François Lhote, Gilles Blaison, Laurent Alric, Christian Agard, David Saadoun, Julie Graveleau, Martin Soubrier, Marie-Josée Lucchini-Lecomte, Christine Christides, Annick Bosseray, Hervé Levesque, Jean-François Viallard, Nathalie Tieulie, Pierre-Yves Lovey, Sylvie Le Moal, Béatrice Bibes, Giuseppe Malizia, Pierre Abgueguen, François Lifermann, Jacques Ninet, Pierre-Yves Hatron, Zahir Amoura
BACKGROUND: Monoclonal gammopathy-associated systemic capillary-leak syndrome, also known as Clarkson disease, is a rare condition characterized by recurrent life-threatening episodes of capillary hyper-permeability in the context of a monoclonal gammopathy. This study was conducted to better describe the clinical characteristics, natural history, and long-term outcome of monoclonal gammopathy-associated systemic capillary-leak syndrome. METHODS: We conducted a cohort analysis of all patients included in the European Clarkson disease (EurêClark) registry between January 1997 and March 2016...
June 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28602873/occam-hickam-troponin-and-appropriate-use
#19
EDITORIAL
Gregory D Chapman
No abstract text is available yet for this article.
June 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28602872/coexistent-primary-biliary-cholangitis-with-crest-syndrome-reynold-s-syndrome
#20
Amirali Kiyani, Shannon Ursu
No abstract text is available yet for this article.
June 8, 2017: American Journal of Medicine
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