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Journal of Physiology

Michael Jonathan Thrippleton
No abstract text is available yet for this article.
December 6, 2018: Journal of Physiology
Hong Chen, Yixue Huang, Xiuqin Zhu, Chong Liu, Yangmian Yuan, Hua Su, Chun Zhang, Chengyu Liu, Mingrui Xiong, Yannan Qu, Peng Yun, Ling Zheng, Kun Huang
KEY POINTS: Diabetic kidney disease (DKD) is a major complication of diabetes. We found that UTX, a histone demethylase, was upregulated in the renal mesangial and tubular cells of diabetic mice and DKD patients. In cultured renal mesangial and tubular cells, UTX overexpression promoted palmitic acid-induced elevation of inflammation and DNA damage; while UTX knockdown or GSK-J4 treatment showed the opposite effects. We found that UTX demethylase activity-dependently regulated the transcription of inflammatory genes and apoptosis; moreover, UTX bound with p53 and p53-dependently exacerbated DNA damage...
December 5, 2018: Journal of Physiology
Sébastien Roger
No abstract text is available yet for this article.
December 5, 2018: Journal of Physiology
Abdulrahman Jama, Dengtong Huang, Abdullah Ali A Alshudukhi, Roman Chrast, Hongmei Ren
KEY POINTS: Lipin1 is critical for skeletal muscle development. Lipin1 regulates MyoD and MEF2c expression through PKC/HDAC5 mediated pathway. Inhibition of PKCμ activity suppresses myoblast differentiation through inhibiting MyoD and MEF2c expression. ABSTRACT: Our previous characterization of global lipin1-deficient (fld) mice demonstrated that lipin1 played a novel role in skeletal muscle (SM) regeneration. This study using cell type-specific Myf5-cre;Lipin1fl/fl conditional knockout mice (Lipin1Myf5cKO ) shows that lipin1 is a major determinant of SM development...
December 4, 2018: Journal of Physiology
João D Mattos, Monique O Campos, Marcos P Rocha, Daniel E Mansur, Helena N M Rocha, Vinicius P Garcia, Gabriel Batista, Thiago S Alvares, Gustavo V Oliveira, Mônica V Souza, Rogério L R Videira, Natalia G Rocha, Niels H Secher, Antonio C L Nóbrega, Igor A Fernandes
KEY POINTS: It is unknown whether excessive reactive oxygen species (ROS) production drives the isocapnic hyperoxia (IH)-induced decline in human cerebral blood flow (CBF) via reduced nitric oxide (NO) bioavailability and leads to disruption of the blood-brain barrier (BBB) or neural-parenchymal damage. We then simultaneously quantified CBF, metabolic rate for oxygen (CMRO2 ) and transcerebral exchanges of NO-end products, oxidant, antioxidant, and neural-parenchymal damage markers under IH with intravenous saline and vitamin C infusion...
December 3, 2018: Journal of Physiology
James A Lang, Jahyun Kim, Warren D Franke, Lauro C Vianna
KEY POINTS: Remote ischaemic preconditioning (RIPC), induced by brief bouts of ischaemia followed by reperfusion, confers vascular adaptations that protect against subsequent bouts of ischaemia. However, the effect of RIPC repeated over several days on the human microcirculation is unknown. Using skin as a model, microvascular function was assessed at a control and a NO-inhibited area of skin before, after, and 1 week after administering seven consecutive days of repeated RIPC on the contralateral arm...
December 2, 2018: Journal of Physiology
Christopher M Hearon, Jennifer C Richards, Mathew L Racine, Gary J Luckasen, Dennis G Larson, Frank A Dinenno
KEY POINTS: In humans, the vasodilatory response to skeletal muscle contraction is mediated in part by activation of inwardly rectifying potassium (KIR ) channels. Evidence from animal models suggest that KIR channels serve as electrical amplifiers of endothelium-dependent hyperpolarization (EDH). We found that skeletal muscle contraction amplifies vasodilatation to the endothelium-dependent agonist acetylcholine (ACh), whereas there was no change in the vasodilatory response to sodium nitroprusside, an endothelium-independent nitric oxide donor...
December 1, 2018: Journal of Physiology
Krishna C Penumatsa, Rod R Warburton, Nicholas S Hill, Barry L Fanburg
No abstract text is available yet for this article.
November 29, 2018: Journal of Physiology
Sally H Vitali
No abstract text is available yet for this article.
November 29, 2018: Journal of Physiology
Krishna C Penumatsa, Rod R Warburton, Nicholas S Hill, Barry L Fanburg
No abstract text is available yet for this article.
November 29, 2018: Journal of Physiology
Sally H Vitali
No abstract text is available yet for this article.
November 29, 2018: Journal of Physiology
Moriah Gildart, Michael S Kapiloff, Kimberly L Dodge-Kafka
The ubiquitous Ca2+ /calmodulin-dependent phosphatase calcineurin is a key regulator of pathological cardiac hypertrophy whose therapeutic targeting in heart disease has been elusive due to its role in other essential biologic processes. Calcineurin is targeted to diverse intracellular compartments by association with scaffold proteins, including by multivalent A-kinase anchoring proteins (AKAPs) that bind PKA and other important signaling enzymes determining cardiac myocyte function and phenotype. Calcineurin anchoring by AKAPs confers specificity to calcineurin function in the cardiac myocyte...
November 29, 2018: Journal of Physiology
Anish Engineer, Shawn S Albers, Andrew S Kucey
No abstract text is available yet for this article.
November 28, 2018: Journal of Physiology
Damian Miles Bailey
No abstract text is available yet for this article.
November 28, 2018: Journal of Physiology
Pui W Cheung, Abby Terlouw, Sam Antoon Janssen, Dennis Brown, Richard Bouley
KEY POINTS: Aquaporin-2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA, and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 c-terminus. It is thought that serine 256 is the master regulator of AQP2 trafficking, and its phosphorylation has to precede the change of phosphorylation state of other serine residues. We found that Src inhibition causes serine 256 independent AQP2 membrane trafficking and induces phosphorylation of serine 269 independent of serine 256...
November 28, 2018: Journal of Physiology
Kevin R DeMarco, Slava Bekker, Igor Vorobyov
Ion channels are implicated in many essential physiological events such as electrical signal propagation and cellular communication. The advent of K+ and Na+ ion channel structure determination has facilitated numerous investigations of molecular determinants of their behavior. At the same time, rapid development of computer hardware and molecular simulation methodologies has made computational studies of large biological molecules in all-atom representation tractable. The concurrent evolution of experimental structural biology with biomolecular computer modeling has yielded mechanistic details of fundamental processes unavailable through experiments alone, such as ion conduction and ion channel gating...
November 24, 2018: Journal of Physiology
Helene H Jensen, Gitte A Pedersen, Jeanette J Morgen, Maddy Parsons, Stine F Pedersen, Lene N Nejsum
Exogenous NHE1 expression stimulated collective migration of epithelial cell sheets Stimulation with epidermal growth factor (EGF), a key morphogen, primarily increased migration of the front row of cells, whereas NHE1 increased that of submarginal cell rows, and the two stimuli were additive Accordingly, NHE1 localized not only to the leading edges of leader cells, but also in cryptic lamellipodia in submarginal cell rows NHE1 expression disrupted the morphology of epithelial cell sheets and 3D cysts ABSTRACT: Collective cell migration plays essential roles in embryonic development, in normal epithelial repair processes, and in many diseases including cancer...
November 24, 2018: Journal of Physiology
Lisa M Walter, Knarik Tamanyan, Aidan J Weichard, Margot J Davey, Gillian M Nixon, Rosemary Sc Horne
KEY POINT SUMMARY: Sleep disordered breathing (SDB) affects 4 - 11% of children and is associated with adverse neurocognitive, behavioural and cardiovascular outcomes, including reduced autonomic control. The relationship between heart rate variability (HRV; a measure of autonomic control), and age found in non-snoring control children was absent during sleep in children with SDB. Age significantly predicted increasing cerebral oxygenation during wake in non-snoring control children, whereas during sleep, HRV significantly predicted decreasing cerebral oxygenation...
November 24, 2018: Journal of Physiology
Mark O Bevensee
Autosomal dominant polycystic kidney disease (ADPKD) is a devastating disease that affects millions of people, and often leads to renal failure, kidney dialysis, and transplantation (Ghata & Cowley Jr, 2017).
November 22, 2018: Journal of Physiology
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