journal
MENU ▼
Read by QxMD icon Read
search

Journal of Physiology

journal
https://www.readbyqxmd.com/read/29052230/omecamtiv-mercabil-and-blebbistatin-modulate-cardiac-contractility-by-perturbing-the-regulatory-state-of-the-myosin-filament
#1
Thomas Kampourakis, Xuemeng Zhang, Yin-Biao Sun, Malcolm Irving
Contraction of heart muscle is triggered by a transient rise in intracellular free calcium concentration linked to a change in the structure of the actin-containing thin filaments that allows the head or motor domains of myosin from the thick filaments to bind to them and induce filament sliding. It is becoming increasingly clear that cardiac contractility is also regulated through structural changes in the thick filaments, although the molecular mechanisms underlying thick filament regulation are still relatively poorly understood...
October 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29052221/advance-in-physiologically-based-pharmacokinetic-modelling-from-the-organ-level-to-sub-organ-level-based-on-experimental-data
#2
Zhoumeng Lin
Understanding the pharmacokinetics and target organ dosimetry properties of small molecular drugs and large molecular biologics is essential in the design of proper therapeutic regimens for disease treatments. This article is protected by copyright. All rights reserved.
October 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29052217/the-comings-and-goings-of-the-vagus-and-the-need-to-know-your-neural-fulcrum
#3
Yee-Hsee Hsieh, Stephen J Lewis
No abstract text is available yet for this article.
October 19, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29044528/endomorphins-potentiate-asic-currents-and-enhance-the-lactic-acid-mediated-increase-in-arterial-blood-pressure-effects-amplified-in-hindlimb-ischemia
#4
Mohamed Farrag, Julie K Drobish, Henry L Puhl, Joyce S Kim, Paul B Herold, Marc P Kaufman, Victor Ruiz-Velasco
Chronic muscle ischemia leads to accumulation of lactic acid and other inflammatory mediators with a subsequent drop in interstitial pH. Acid-sensing ion channels (ASICs), expressed in thin muscle afferents, sense the decrease in pH and evoke a pressor reflex known to increase mean arterial pressure. The naturally occurring endomorphins are also released by primary afferents under ischemic conditions. We examined whether high affinity mu opioid receptor (MOR) agonists, endomorphin-1 (E-1) and -2 (E-2), modulate ASIC currents and the lactic acid-mediated pressor reflex...
October 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29034480/antioxidant-therapy-in-a-mouse-model-of-duchenne-muscular-dystrophy-some-promising-results-but-with-a-weighty-caveat
#5
Stewart I Head
Antioxidants have been proposed as potential therapies for a host of cardiac and neuromuscular conditions. This article is protected by copyright. All rights reserved.
October 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29034474/altered-nmda-receptor-evoked-intracellular-ca-2-dynamics-in-magnocellular-neurosecretory-neurons-of-hypertensive-rats
#6
Meng Zhang, Javier E Stern
A growing body of evidence supports an elevated NMDA receptor-mediated glutamate excitatory function in the SON and PVN of hypertensive rats that contributes to neurohumoral activation in this disease. Still, the precise mechanisms underlying altered NMDAR signalling in hypertension remains to be elucidated. In this study, we performed simultaneous electrophysiology and fast confocal Ca(2+) imaging to determine whether an altered NMDAR-mediated changes in intracellular Ca(2+) levels (NMDAR-ΔCa(2+) ) occurred in hypothalamic magnocellular neurosecretory cells (MNCs) in renovascular hypertensive (RVH) rats...
October 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29034468/using-the-common-marmoset-for-neurophysiological-studies-of-neocortical-functions
#7
Tadashi Isa
The common marmoset is a small new world monkey and highlighted as an experimental primate model species to which the genetic engineering techniques have become applicable. This article is protected by copyright. All rights reserved.
October 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29028113/the-role-of-plin-protein-in-healthy-lipid-storage-and-lipid-droplet-expansion
#8
G C Hayward, R K Fenech, A J Yang, B J Baranowski
In skeletal muscle, fatty acids are stored in vesicle-like organelles known as lipid droplets (LDs). The importance of how lipids are stored in skeletal muscle has emerged from studies demonstrating a strong association between muscle lipids and insulin sensitivity. This article is protected by copyright. All rights reserved.
October 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29028112/the-role-of-declining-adaptive-homeostasis-in-ageing
#9
Laura C D Pomatto, Kelvin J A Davies
Adaptive homeostasis is, 'the transient expansion or contraction of the homeostatic range for any given physiological parameter in response to exposure to sub-toxic, non-damaging, signalling molecules or events, or the removal or cessation of such molecules or events (Davies, 2016a)." Adaptive homeostasis enables biological systems to make continuous short-term adjustments for optimal functioning despite ever-changing internal and external environments. Initiation of adaptation in response to an appropriate signal allows organisms to successfully cope with much greater, normally toxic, stresses...
October 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29027203/phylogenetically-persistent-purinergic-modulation-of-central-pattern-generators-for-breathing-in-lamprey-and-mammals
#10
Gregory D Funk
Vertebrate behaviours are produced by neuroglial networks that evolved from a common set of ancestral (homologous) traits, as well as unique specializations that created opportunities for new behaviours and exploitation of novel environments. This article is protected by copyright. All rights reserved.
October 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023798/intrathecal-antibody-distribution-in-the-rat-brain-surface-diffusion-perivascular-transport-and-osmotic-enhancement-of-delivery
#11
Michelle E Pizzo, Daniel J Wolak, Niyanta N Kumar, Eric Brunette, Christina L Brunnquell, Melanie-Jane Hannocks, N Joan Abbott, M Elizabeth Meyerand, Lydia Sorokin, Danica B Stanimirovic, Robert G Thorne
The precise mechanisms governing the central distribution of macromolecules from the cerebrospinal fluid (CSF) to the brain and spinal cord remain poorly understood, despite their importance for physiological processes such as antibody trafficking for central immune surveillance as well as several ongoing intrathecal clinical trials. Here, we clarify how immunoglobulin G (IgG) and smaller single-domain antibodies (sdAb) distribute throughout the whole brain in a size-dependent manner after intrathecal infusion in rats using ex vivo fluorescence and in vivo 3D magnetic resonance imaging...
October 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023793/crosstalk-proposal-proton-permeation-through-hv-1-requires-transient-protonation-of-a-conserved-aspartate-in-the-s1-transmembrane-helix
#12
Thomas E DeCoursey
No abstract text is available yet for this article.
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023792/rebuttal-from-thomas-e-decoursey
#13
Thomas E DeCoursey
No abstract text is available yet for this article.
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023737/oxidative-phosphorylation-regulation-and-role-in-cellular-and-tissue-metabolism
#14
David F Wilson
Oxidative phosphorylation provides most of the ATP that higher animals and plants use to support life and is responsible for setting and maintaining metabolic homeostasis. The pathway incorporates three consecutive near equilibrium steps for moving reducing equivalents between the intramitochondrial [NAD(+) ]/[NADH] pool to molecular oxygen, with irreversible reduction of oxygen to bound peroxide at cytochrome c oxidase determining the net flux. Net flux (oxygen consumption rate) is determined by demand for ATP, with feedback by the energy state ([ATP]/[ADP][Pi]) regulating the pathway...
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023736/an-investigation-of-fetal-behavioural-states-during-maternal-sleep-in-healthy-late-gestation-pregnancy-an-observational-study
#15
Peter R Stone, Wendy Burgess, Jordan McIntyre, Alistair J Gunn, Christopher A Lear, Laura Bennet, Edwin A Mitchell, John M D Thompson
BACKGROUND: Fetal behavioural states (FBS) are measures of fetal wellbeing. Maternal position affects FBS with supine being associated with an increased likelihood of fetal quiescence consistent with the human fetus adapting to a lower oxygen consuming state. A number of studies now confirm the association of sleep position with risk of late intrauterine death. We designed this study to observe the effects of maternal sleep positions overnight in healthy late gestation pregnancy. METHOD: Twenty nine healthy women had continuous fetal ECG recordings overnight...
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023731/physiological-tremor-increases-when-skeletal-muscle-is-shortened-implications-for-fusimotor-control
#16
Kian Jalaleddini, Akira Nagamori, Christopher M Laine, Mahsa A Golkar, Robert E Kearney, Francisco J Valero-Cuevas
The involuntary force fluctuations associated with physiological (as distinct from pathological) tremor are an unavoidable component of human motor control. While the origins of physiological tremor are known to depend on muscle afferentation, it is possible that the mechanical properties of muscle-tendon systems also affect its generation, amplification and maintenance. In this paper, we investigated the dependence of physiological tremor on muscle length in healthy individuals. We measured physiological tremor during tonic, isometric plantarflexion torque at 30% of maximum at three ankle angles...
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023730/crosstalk-opposing-view-proton-transfer-in-hv1-utilizes-a-water-wire-and-does-not-require-transient-protonation-of-a-conserved-aspartate-in-the-s1-transmembrane-helix
#17
Ashley L Bennett, Ian Scott Ramsey
No abstract text is available yet for this article.
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023729/rebuttal-from-ashley-l-bennett-and-ian-scott-ramsey
#18
Ashley L Bennett, Ian Scott Ramsey
No abstract text is available yet for this article.
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023784/plasma-membrane-ca-2-atpase-1-is-required-for-maintaining-atrial-ca-2-homeostasis-and-electrophysiological-stability-in-the-mouse
#19
Yanwen Wang, Claire Wilson, Elizabeth J Cartwright, Ming Lei
To determine the role of PMCA1 in maintaining Ca(2+) homeostasis and electrical stability in the atrium under physiological and stress conditions, mice with a cardiomyocyte-specific deletion of PMCA1 (PMCA1(cko) ) and their control littermates (PMCA1(loxP/loxP) ) were studied at the organ and cellular levels.   At the organ level, the PMCA1(cko) hearts became more susceptible to atrial arrhythmias under rapid programmed electrical stimulation (PES) compared with the PMCA1(loxP/loxP) hearts, and such arrhythmic events became more severe under Ca(2+) overload conditions...
October 10, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29023733/tonic-inhibition-of-brown-adipose-tissue-sympathetic-nerve-activity-via-muscarinic-acetylcholine-receptors-in-the-rostral-raphe-pallidus
#20
Ellen Paula Santos da Conceição, Christopher J Madden, Shaun F Morrison
We sought to determine if body temperature and energy expenditure are influenced by a cholinergic input to neurons in the rostral raphe pallidus (rRPa), the site of sympathetic premotor neurons controlling brown adipose tissue (BAT) thermogenesis. Nanoinjections of the muscarinic acetylcholine receptor (mAChR) receptor agonist, oxotremorine, or the cholinesterase inhibitor, neostigmine (NEOS), in the rRPa of anaesthetized rats decreased cold-evoked BAT sympathetic nerve activity (SNA, nadirs: -72%, and -95%), BAT temperature (TBAT, -0...
October 10, 2017: Journal of Physiology
journal
journal
22668
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"