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Journal of Molecular and Cellular Cardiology

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https://www.readbyqxmd.com/read/29684406/conservation-of-cardiac-l-type-ca-2-channels-and-their-regulation-in-drosophila-a-novel-genetically-pliable-channelopathic-model
#1
Worawan B Limpitikul, Meera C Viswanathan, Brian O'Rourke, David T Yue, Anthony Cammarato
Dysregulation of L-type Ca2+ channels (LTCCs) underlies numerous cardiac pathologies. Understanding their modulation with high fidelity relies on investigating LTCCs in their native environment with intact interacting proteins. Such studies benefit from genetic manipulation of endogenous channels in cardiomyocytes, which often proves cumbersome in mammalian models. Drosophila melanogaster, however, offers a potentially efficient alternative as it possesses a relatively simple heart, is genetically pliable, and expresses well-conserved genes...
April 20, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29680681/hdac-inhibition-helps-post-mi-healing-by-modulating-macrophage-polarization
#2
Denise Kimbrough, Sabina H Wang, Lillianne H Wright, Santhosh K Mani, Harinath Kasiganesan, Mandy La Rue, Qi Cheng, Satish N Nadig, Carl Atkinson, Donald R Menick
AIMS: Following an acute myocardial infarction (MI) the extracellular matrix (ECM) undergoes remodeling in order to prevent dilation of the infarct area and maintain cardiac output. Excessive and prolonged inflammation following an MI exacerbates adverse ventricular remodeling. Macrophages are an integral part of the inflammatory response that contribute to this remodeling. Treatment with histone deacetylase (HDAC) inhibitors preserves LV function and myocardial remodeling in the post-MI heart...
April 19, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29674140/impaired-ca-2-cycling-of-nonischemic-myocytes-contributes-to-sarcomere-dysfunction-early-after-myocardial-infarction
#3
Annette Kronenbitter, Florian Funk, Katarzyna Hackert, Simone Gorreßen, Dennis Glaser, Peter Boknik, Gereon Poschmann, Kai Stühler, Malgorzata Isić, Martina Krüger, Joachim P Schmitt
Changes in the nonischemic remote myocardium of the heart contribute to left ventricular dysfunction after ischemia and reperfusion (I/R). Understanding the underlying mechanisms early after I/R is crucial to improve the adaptation of the viable myocardium to increased mechanical demands. Here, we investigated the role of myocyte Ca2+ handling in the remote myocardium 24 h after 60 min LAD occlusion. Cardiomyocytes isolated from the basal noninfarct-related parts of wild type mouse hearts demonstrated depressed beat-to-beat Ca2+ handling...
April 16, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29660306/ablation-of-toll-like-receptor-4-attenuates-aging-induced-myocardial-remodeling-and-contractile-dysfunction-through-ncori-hdac1-mediated-regulation-of-autophagy
#4
Shuyi Wang, Wei Ge, Carrie Harns, Xianzhong Meng, Yingmei Zhang, Jun Ren
Aging is usually accompanied with overt structural and functional changes as well as suppressed autophagy in the heart although the precise regulatory mechanisms are somewhat unknown. Here we evaluated the role of the innate proinflammatory mediator toll-like receptor 4 (TLR4) in cardiac aging and the underlying mechanism with a focus on autophagy. Cardiac geometry and function were monitored in young or old wild-type (WT) and TLR4 knockout (TLR4-/- ) mice using echocardiography, IonOptix® edge-detection and fura-2 techniques...
April 13, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29654879/anti-oxidant-effect-of-bergamot-polyphenolic-fraction-counteracts-doxorubicin-induced-cardiomyopathy-role-of-autophagy-and-c-kit-pos-cd45-neg-cd31-neg-cardiac-stem-cell-activation
#5
Cristina Carresi, Vincenzo Musolino, Micaela Gliozzi, Jessica Maiuolo, Rocco Mollace, Saverio Nucera, Alessia Maretta, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Ernesto Palma, Francesca Bosco, Caterina Giancotta, Carolina Muscoli, Fabiola Marino, Iolanda Aquila, Daniele Torella, Franco Romeo, Vincenzo Mollace
Doxorubicin (DOXO) is one of the most widely used antineoplastic drugs. Despite its highly beneficial effects against several malignancies, the clinical use of DOXO is often associated to cardiomyopathy that leads to congestive heart failure. Here we investigated the antioxidant and cardioprotective effects of a polyphenol-rich fraction of citrus bergamot (BPF), in DOXO-induced cardiac damage in rats. Moreover, we evaluated the effect of BPF on cardiomyocyte survival and resident endogenous cardiac stem/progenitor cell (eCSC) activation...
April 12, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29654880/neural-bayes-network-predictor-for-inheritable-cardiac-disease-pathogenicity-and-phenotype
#6
Thomas P Burghardt, Katalin Ajtai
The cardiac muscle sarcomere contains multiple proteins contributing to contraction energy transduction and its regulation during a heartbeat. Inheritable heart disease mutants affect most of them but none more frequently than the ventricular myosin motor and cardiac myosin binding protein c (mybpc3). These co-localizing proteins have mybpc3 playing a regulatory role to the energy transducing motor. Residue substitution and functional domain assignment of each mutation in the protein sequence decides, under the direction of a sensible disease model, phenotype and pathogenicity...
April 11, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29653111/a-brain-within-the-heart-a-review-on-the-intracardiac-nervous-system
#7
REVIEW
Isabel Durães Campos, Vitor Pinto, Nuno Sousa, Vitor H Pereira
Cardiac function is under the control of the autonomic nervous system, composed by the parasympathetic and sympathetic divisions, which are finely tuned at different hierarchical levels. While a complex regulation occurs in the central nervous system involving the insular cortex, the amygdala and the hypothalamus, a local cardiac regulation also takes place within the heart, driven by an intracardiac nervous system. This complex system consists of a network of ganglionic plexuses and interconnecting ganglions and axons...
April 10, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29634917/ca-2-handling-remodeling-and-stim1l-orai1-trpc1-trpc4-upregulation-in-monocrotaline-induced-right-ventricular-hypertrophy
#8
Sabourin Jessica, Boet Angèle, Rucker-Martin Catherine, Lambert Mélanie, Gomez Ana-Maria, Benitah Jean-Pierre, Perros Frédéric, Humbert Marc, Antigny Fabrice
BACKGROUND: Right ventricular (RV) function is the most important prognostic factor for pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary vascular resistance induces RV hypertrophy (RVH) and at term RV failure (RVF). However, the molecular mechanisms of RVH and RVF remain understudied. In this study, we gained insights into cytosolic Ca2+ signaling remodeling in ventricular cardiomyocytes during the pathogenesis of severe pulmonary hypertension (PH) induced in rats by monocrotaline (MCT) exposure, and we further identified molecular candidates responsible for this Ca2+ remodeling...
April 7, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29627294/%C3%AE-arrestin-biased-agonism-of-%C3%AE-adrenergic-receptor-regulates-dicer-mediated-microrna-maturation-to-promote-cardioprotective-signaling
#9
Jian-Peng Teoh, Ahmed S Bayoumi, Tatsuya Aonuma, Yanyan Xu, John A Johnson, Huabo Su, Neal L Weintraub, Yaoliang Tang, Il-Man Kim
RATIONALE: MicroRNAs (miRs) are small, non-coding RNAs that function to post-transcriptionally regulate target genes. First transcribed as primary miR transcripts (pri-miRs), they are enzymatically processed by Drosha into premature miRs (pre-miRs) and further cleaved by Dicer into mature miRs. Initially discovered to desensitize β-adrenergic receptor (βAR) signaling, β-arrestins are now well-appreciated to modulate multiple pathways independent of G protein signaling, a concept known as biased signaling...
April 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29627295/deficiency-of-aldose-reductase-exacerbates-early-pressure-overload-induced-cardiac-dysfunction-and-autophagy-in-mice
#10
Shahid P Baba, Deqing Zhang, Mahavir Singh, Sujith Dassanayaka, Zhengzhi Xie, Ganapathy Jagatheesan, Jingjing Zhao, Virginia K Schmidtke, Kenneth R Brittian, Michael L Merchant, Daniel J Conklin, Steven P Jones, Aruni Bhatnagar
Pathological cardiac hypertrophy is associated with the accumulation of lipid peroxidation-derived aldehydes such as 4-hydroxy-trans-2-nonenal (HNE) and acrolein in the heart. These aldehydes are metabolized via several pathways, of which aldose reductase (AR) represents a broad-specificity route for their elimination. We tested the hypothesis that by preventing aldehyde removal, AR deficiency accentuates the pathological effects of transverse aortic constriction (TAC). We found that the levels of AR in the heart were increased in mice subjected to TAC for 2 weeks...
April 5, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29626503/hsf1-deficiency-accelerates-the-transition-from-pressure-overload-induced-cardiac-hypertrophy-to-heart-failure-through-endothelial-mir-195a-3p-mediated-impairment-of-cardiac-angiogenesis
#11
Shijun Wang, Jian Wu, Jieyun You, Hongyu Shi, Xiaoyu Xue, Jiayuan Huang, Lei Xu, Guoliang Jiang, Lingyan Yuan, Xue Gong, Haiyan Luo, Junbo Ge, Zhaoqiang Cui, Yunzeng Zou
Heat shock transcription factor 1 (HSF1) deficiency aggravates cardiac remodeling under pressure overload. However, the mechanism is still unknown. Here we employed microRNA array analysis of the heart tissue of HSF1-knockout (KO) mice to investigate the potential roles of microRNAs in pressure overload-induced cardiac remodeling under HSF-1 deficiency, and the profiles of 478 microRNAs expressed in the heart tissues of adult HSF1-KO mice were determined. We found that the expression of 5 microRNAs was over 2-fold higher expressed in heart tissues of HSF1-KO mice than in those of wild-type (WT) control mice...
April 4, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29625729/corrigendum-to-elevated-20-hete-in-metabolic-syndrome-regulates-arterial-stiffness-and-systolic-hypertension-via-mmp12-activation-j-mol-cell-cardiol-117-2018-88-99
#12
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Jenny Yang, Frank Fan Zhang, Sachindra Raj Joshi, Chastity Bradford, Katherine H Gotlinger, Rachana Maniyar, John R Falck, Spencer Proctor, Michal Laniado Schwartzman, Sachin A Gupte, Petra Rocic
No abstract text is available yet for this article.
April 4, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29614261/the-novel-camkii-inhibitor-gs-680-reduces-diastolic-sr-ca-leak-and-prevents-camkii-dependent-pro-arrhythmic-activity
#13
S Lebek, A Plößl, M Baier, J Mustroph, D Tarnowski, C M Lücht, S Schopka, B Floerchinger, C Schmid, Y Zausig, N Pagratis, B Marchand, D O Koltun, W K Hung, S Ahmadyar, L Belardinelli, L S Maier, S Wagner
RATIONALE: Ca/calmodulin-dependent protein kinase II (CaMKII) was shown to increase diastolic sarcoplasmic reticulum (SR) Ca leak, which can result in delayed afterdepolarizations and triggered arrhythmias. Since increased CaMKII expression and activity has been mechanistically linked to arrhythmias in human heart failure (HF) and atrial fibrillation (AF), specific strategies aimed at CaMKII inhibition may have therapeutic potential. OBJECTIVE: We tested the antiarrhythmic and inotropic effects of a novel selective and ATP-competitive CaMKII inhibitor (GS-680)...
March 31, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29608885/microrna-223-protects-neonatal-rat-cardiomyocytes-and-h9c2-cells-from-hypoxia-induced-apoptosis-and-excessive-autophagy-via-the-akt-mtor-pathway-by-targeting-parp-1
#14
Xiaoxiao Liu, Yunfei Deng, Yifeng Xu, Wei Jin, Hongli Li
Myocardial infarction (MI), characterized by interruption of blood and oxygen to myocardium, is a common yet fatal cardiovascular event that causes progressive damage to myocardial tissue and eventually leads to heart failure. Previous studies have shown increased expression of microRNA-223 (miR-223) in infarcted myocardial tissues of humans and in rat models of MI. However, the role of miR-223 in cell survival during MI has not been elucidated. Thus, we aimed to investigate whether miR-223 participates in the regulation of cardiac ischemia-induced injury and to elucidate the underlying mechanisms of this process...
March 30, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29605530/zinc-improves-mitochondrial-respiratory-function-and-prevents-mitochondrial-ros-generation-at-reperfusion-by-phosphorylating-stat3-at-ser-727
#15
Ge Zhang, Mingwei Sheng, Jiannan Wang, Tianming Teng, Yuemin Sun, Qing Yang, Zhelong Xu
Serine 727 (Ser727 ) phosphorylation of STAT3 plays a role in the regulation of mitochondrial respiration. This study aimed to test if zinc could regulate mitochondrial respiration through phosphorylation of STAT3 at Ser727 in the setting of ischemia/reperfusion in the heart. Under normoxic conditions, treatment of isolated rat hearts with ZnCl2 increased cytosolic STAT3 phosphorylation at Ser727 followed by phospho-STAT3 translocation to mitochondria. In isolated rat hearts subjected to 30 min regional ischemia followed by 20 min of reperfusion, ZnCl2 given 5 min before the onset of reperfusion also increased mitochondrial phospho-STAT3...
March 29, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29604261/afterload-promotes-maturation-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-in-engineered-heart-tissues
#16
Andrea Leonard, Alessandro Bertero, Joseph D Powers, Kevin M Beussman, Shiv Bhandari, Michael Regnier, Charles E Murry, Nathan J Sniadecki
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart repair. However, the immaturity of hiPSC-CMs currently limits their use. Because mechanical loading increases during development and facilitates cardiac maturation, we hypothesized that afterload would promote maturation of EHTs. To test this we developed a system in which EHTs are suspended between a rigid post and a flexible one, whose resistance to contraction can be modulated by applying braces of varying length...
March 28, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29588139/pragmatic-statistical-issues-in-biological-research-introduction-to-special-series
#17
Robert S Danziger, Michael L Berbaum
This is an introduction to a special series so an abstract may not be required (but some verbiage is needed in this space to submit!!).
March 24, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29577873/intermittent-hypoxia-generated-ros-contributes-to-intracellular-zinc-regulation-that-limits-ischemia-reperfusion-injury-in-adult-rat-cardiomyocyte
#18
Chih-Feng Lien, Wen-Sen Lee, I-Chieh Wang, Tsung-I Chen, Tzu-Lin Chen, Kun-Ta Yang
Intermittent hypoxia (IH) has been shown to exert cardioprotective effects against ischemia/reperfusion (I/R) injury through the preservation of ion homeostasis. I/R dramatically elevated cytosolic Zn2+ and caused cardiomyocyte death. However, the role of IH exposure in the relationship between Zn2+ regulation and cardioprotection is still unclear. The aim of the present study was to study whether IH exposure could help in intracellular Zn2+ regulation, hence contributing to cardioprotection against I/R injury...
March 22, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29551391/modelling-the-pathogenesis-of-myotonic-dystrophy-type-1-cardiac-phenotype-through-human-ipsc-derived-cardiomyocytes
#19
Paola Spitalieri, Rosa V Talarico, Silvia Caioli, Michela Murdocca, Annalucia Serafino, Marco Girasole, Simone Dinarelli, Giovanni Longo, Sabina Pucci, Annalisa Botta, Giuseppe Novelli, Cristina Zona, Ruggiero Mango, Federica Sangiuolo
Myotonic Dystrophy type 1 (DM1) is a multisystemic disease, autosomal dominant, caused by a CTG repeat expansion in DMPK gene. We assessed the appropriateness of patient-specific induced pluripotent stem cell-derived cardiomyocytes (CMs) as a model to recapitulate some aspects of the pathogenetic mechanism involving cardiac manifestations in DM1 patients. Once obtained in vitro, CMs have been characterized for their morphology and their functionality. CMs DM1 show intranuclear foci and transcript markers abnormally spliced respect to WT ones, as well as several irregularities in nuclear morphology, probably caused by an unbalanced lamin A/C ratio...
March 15, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29549046/shear-stress-an-essential-driver-of-endothelial-progenitor-cells
#20
REVIEW
Anton G Kutikhin, Maxim Yu Sinitsky, Arseniy E Yuzhalin, Elena A Velikanova
The blood flow through vessels produces a tangential, or shear, stress sensed by their innermost layer (i.e., endothelium) and representing a major hemodynamic force. In humans, endothelial repair and blood vessel formation are mainly performed by circulating endothelial progenitor cells (EPCs) characterized by a considerable expression of vascular endothelial growth factor receptor 2 (VEGFR2), CD34, and CD133, pronounced tube formation activity in vitro, and strong reendothelialization or neovascularization capacity in vivo...
March 13, 2018: Journal of Molecular and Cellular Cardiology
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