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Monatshefte Für Chemie

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https://www.readbyqxmd.com/read/30237621/synthesis-of-2-alkylthio-n-quinazolin-2-yl-benzenesulfonamide-derivatives-anticancer-activity-qsar-studies-and-metabolic-stability
#1
Aneta Pogorzelska, Beata Żołnowska, Jarosław Sławiński, Anna Kawiak, Krzysztof Szafrański, Mariusz Belka, Tomasz Bączek
A new series of 2-alkylthio- N -(quinazolin-2-yl)benzenesulfonamide derivatives have been synthesized and evaluated in vitro for their antiproliferative activity by MTT assay against cancer cell lines HCT-116, MCF-7, and HeLa as well as the NCI-60 human tumor cell lines screen. In NCI screen, three compounds inhibited approximately 50% growth of RPMI-8226 and A549/ATCC cell lines. The mean of IC50 calculated in MTT assays for three tested cell lines was about 45 μM for four compounds. The QSAR allowed finding statistically significant OPLS models for HeLa cell line...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30237620/regiospecific-formation-of-the-nitromethyl-substituted-3-phenyl-4-5-dihydroisoxazole-via-3-2-cycloaddition
#2
Barbara Mirosław, Dmytro Babyuk, Agnieszka Łapczuk-Krygier, Agnieszka Kącka-Zych, Oleg M Demchuk, Radomir Jasiński
5-(Nitromethyl)-3-phenyl-4,5-dihydroisoxazole was obtained as a product of a high-yielding [3 + 2] cycloaddition reaction of in situ-generated benzonitrile N -oxide and 3-nitroprop-1-ene. For the first time, the regiochemistry of this reaction was unambiguously proven by X-ray structural analysis. The quantum-chemical calculation performed at the M06-2X/6-31G(d) (PCM) theoretical level affords a basis for explaining the course of reaction as well as the nature of transition states. Next, further DFT calculations together with spectral data shed light on structural aspects of the product...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30237619/serum-binding-properties-of-isosteric-ruthenium-and-osmium-anticancer-agents-elucidated-by-sec-icp-ms
#3
Matthias H M Klose, Anna Schöberl, Petra Heffeter, Walter Berger, Christian G Hartinger, Gunda Koellensperger, Samuel M Meier-Menches, Bernhard K Keppler
Size-exclusion chromatography-inductively coupled plasma-mass spectrometry (SEC-ICP-MS) was used to study the serum-binding preferences of two metallodrugs with anticancer activities in vivo, namely the organoruthenium compound plecstatin-1 and its isosteric osmium analog. The complexes were administered intraperitoneally into mice bearing a CT-26 tumor. Comparing the total metal content of mouse whole blood and serum underlined that the metallodrugs are mainly located in serum and not in the cellular fraction of the blood samples...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174352/monitoring-of-n-butanol-vapors-biofiltration-process-using-an-electronic-nose-combined-with-calibration-models
#4
Bartosz Szulczyński, Piotr Rybarczyk, Jacek Gębicki
Malodorous odors, by definition, are unpleasant, irritating smells being a mixture of volatile chemical compounds that can be sensed at low concentrations. Due to the increasing problem of odor nuisance associated with odor sensations, and thus the need to remove them from the air, deodorization techniques are commonly used. Biofiltration is one of the methods of reducing odorants in the air stream. In the paper, the possibility of using an electronic nose as an alternative method to gas chromatography for the online monitoring and evaluation of efficiency of the n -butanol vapors biofiltration process in a transient state was investigated...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174351/analytical-and-legislative-challenges-of-sewage-sludge-processing-and-management
#5
Bartłomiej Michał Cieślik, Lesław Świerczek, Piotr Konieczka
This article presents the most popular methods of sewage sludge management and analytical techniques which could be a powerful tool in designing new sewage sludge management methods. Chemical analysis is also described as a vital point at the subsequent stages of technological processes control and sewage sludge quality assessment. It is also an instrument essential to maintaining control of processed sewage sludge introduced to the environment as ready-to-use materials. The sludge management method is conditioned by the compliance with legal acts concerning sludge management...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174350/analysis-of-volatile-fraction-of-sweetie-citrus-maxima-%C3%A3-citrus-paradisi-and-its-parent-fruit-using-proton-transfer-reaction-mass-spectrometry
#6
Anna Różańska, Dorota Sieńska, Tomasz Dymerski, Jacek Namieśnik
The quality of the fruit is affected by several main ingredients and the aroma plays a fundamental role during the selection of fruit by consumers. In the case where several fruit have similar aromas and only one of them has specific health properties, it is very important to find the differences in the volatile organic compounds (VOCs) composition to distinguish these samples. Such situations are often found for hybrid fruit. Sweetie is a hybrid of grapefruit and pummelo. Sweetie fruit is characterized by high antioxidant potential and a positive effect on human health...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174349/novel-analytical-method-for-detection-of-orange-juice-adulteration-based-on-ultra-fast-gas-chromatography
#7
Anna Różańska, Tomasz Dymerski, Jacek Namieśnik
The food authenticity assessment is an increasingly important issue in food quality and safety. The application of an electronic nose based on ultra-fast gas chromatography technique enables rapid analysis of the volatile compounds from food samples. Due to the fact that this technique provides chemical profiling of natural products, it can be a powerful tool for authentication in combination with chemometrics. In this article, a methodology for classification of Not From Concentrate (NFC) juices was presented...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174348/rapid-assessment-of-the-authenticity-of-limequat-fruit-using-the-electronic-nose-and-gas-chromatography-coupled-with-mass-spectrometry
#8
Martyna Lubinska-Szczygeł, Dominika Pudlak, Tomasz Dymerski, Jacek Namieśnik
Citrus fruits are very popular food products. There are many species and varieties of them. There are also documented cases of some citrus fruits causing a severe allergic reaction. Some species of the citrus fruits, especially hybrid ones show a reduced allergenic effect due to the lack of seeds. There is a need for rapid methods for evaluation of citrus' botanical origin. During research, the headspace of three citrus fruits Citrus Aurantifolia, Citrus japonica , and Citrus  ×  floridana was analysed using electronic nose based on ultrafast gas chromatography and gas chromatography with mass spectrometry...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174347/the-use-of-rp-hplc-q-tof-ms-as-a-powerful-tool-for-wastewater-composition-profiling-and-selection-of-water-pollution-marker-specific-to-wastewater-contamination
#9
Dagmara Kempińska, Agata Kot-Wasik
Limited drinking water resources and water pollution are one of the main worldwide problems. To reduce the consumption of fresh water resources, the use of treated wastewater has been proposed. The farmlands have been irrigated with wastewater for centuries, but the composition of used sewage has changed over the years. Recent research has revealed the presence of hundreds of new organic contaminants in many environmental waters, including wastewaters and their receivers. For this reason, wastewater profiling and monitoring are of high importance and urgent need...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174346/complementary-use-of-gcxgc-tof-ms-and-statistics-for-differentiation-of-variety-in-biosolid-samples
#10
Hubert Byliński, Tomasz Dymerski, Jacek Gębicki, Jacek Namieśnik
No abstract text is available yet for this article.
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174345/reliable-calibration-by-nonlinear-standard-addition-method-in-the-presence-of-additive-interference-effects
#11
Marcin Wieczorek, Marek Dębosz, Paweł Świt, Aleksandra Piech, Joanna Kasperek, Paweł Kościelniak
The possibility of adapting the Standard Addition Method (SAM) to calibration in very difficult analytical conditions, namely when there is a need to determine an analyte with the use of nonlinear calibration graph and in the presence of matrix components causing additive interference effect, is investigated. To this aim the SAM in the common version and the Chemical H-point Standard Addition Method (C-HPSAM) realized by the flow injection technique were applied. Specifically, a flow manifold was used for construction of a set of nonlinear calibration graphs in different chemical conditions...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174344/a-new-method-for-real-time-monitoring-of-volatiles-in-frying-fumes-using-proton-transfer-reaction-mass-spectrometry-with-time-of-flight-analyser
#12
Tomasz Majchrzak, Wojciech Wojnowski, Tomasz Dymerski, Jacek Gębicki, Jacek Namieśnik
To safeguard the consumers' well-being, it is necessary to develop novel methods for determination of carcinogens in food, including volatiles generated during frying. The currently used procedures for analysis of volatile fraction of vegetable oils are not based on real-time measurements and thus do not enable the determination of carcinogenic compounds in frying fumes; instead, only the headspace or liquid fraction is sampled. In this article, described is an approach in which proton transfer reaction mass spectrometry with time-of-flight analyser (PTR-TOFMS) was used for real-time monitoring of carcinogenic compounds generated during thermal degradation of rapeseed oil...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30174343/direct-determination-of-cadaverine-in-the-volatile-fraction-of-aerobically-stored-chicken-breast-samples
#13
Wojciech Wojnowski, Justyna Płotka-Wasylka, Kaja Kalinowska, Tomasz Majchrzak, Tomasz Dymerski, Piotr Szweda, Jacek Namieśnik
To supplement the currently used methods for poultry meat shelf life assessment, it might be necessary to develop a technique for rapid headspace analysis of volatiles with no prior sample preparation step. Biogenic amines, in particular cadaverine, are considered meat spoilage indicators. Described in this article are the results of a preliminary investigation of the applicability of proton transfer reaction mass spectrometry in the determination of cadaverine concentration in the volatile fraction of poultry meat samples stored in aerobic conditions...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30100633/synthesis-and-evaluation-of-new-amidrazone-derived-hydrazides-as-a-potential-anti-inflammatory-agents
#14
Renata Paprocka, Małgorzata Wiese-Szadkowska, Anna Helmin-Basa, Liliana Mazur, Jolanta Kutkowska, Jacek Michałkiewicz, Bożena Modzelewska-Banachiewicz, Leszek Pazderski
The series of new hydrazide derivatives were synthesized in reactions of N3 -substituted amidrazones with cyclic anhydrides as potential anti-inflammatory and antibacterial agents. The compounds were characterized by 1 H-13 C two-dimensional NMR techniques, which revealed the presence of two tautomeric forms in DMSO- d 6 solutions, while the molecular structure of one species was confirmed by single-crystal X-ray diffraction. The anti-inflammatory effects of hydrazides on peripheral blood mononuclear cells were experimentally evaluated...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30100632/synthesis-of-unsymmetrical-disulfanes-bearing-1-2-4-triazine-scaffold-and-their-in-vitro-screening-towards-anti-breast-cancer-activity
#15
Danuta Branowska, Justyna Ławecka, Mariusz Sobiczewski, Zbigniew Karczmarzyk, Waldemar Wysocki, Ewa Wolińska, Ewa Olender, Barbara Mirosław, Alicja Perzyna, Anna Bielawska, Krzysztof Bielawski
A new series of 1,2,4-triazine unsymmetrical disulfanes were prepared and evaluated as anticancer activity compounds against MCF-7 human breast cancer cells with some of them acting as low micromolar inhibitors. Evaluation of the cytotoxicity using an MTT assay, the inhibition of [3 H]-thymidine incorporation into DNA demonstrated that these products exhibit cytotoxic effects on breast cancer cells in vitro. The most effective compounds with 59 and 60 µM compared to chlorambucil with 47 µM were disulfanes bearing methyl and methoxy substituent in an aromatic ring...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30100631/adsorption-of-adenine-on-mercury-electrode-in-acetate-buffer-at-ph-5-and-ph-6-and-its-effect-on-electroreduction-of-zinc-ions
#16
Dorota Gugała-Fekner
The measurements of double-layer differential capacitance, zero charge potential, and surface tension at that potential allowed us to examine the adsorption properties of adenine on the mercury surface from the neat buffer solution, i.e., the acetate buffer at pH 5 and pH 6. The systems obtained at such pH values were close to physiological fluids in their characteristics. The adsorption energy and interaction constants were determined using Frumkin isotherm and virial isotherm. It was shown that the adenine molecule is adsorbed on the mercury electrode with its negative pole against the electrode surface...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30100630/umbelliferone-instability-during-an-analysis-involving-its-extraction-process
#17
Andrzej L Dawidowicz, Katarzyna Bernacik, Rafał Typek
Umbelliferone (7-hydroxycoumarin) is one of the most popular compounds of the coumarins family. This compound receives the attention of scientists due to its diverse bioactivities in a number of applications in various therapeutic fields. An interesting aspect of umbelliferone is its structural lability. The enzymatic degradation process of umbelliferone to its hydroxylated (esculetin), glucosylated (skimmin), and methylated (herniarin) derivatives is already known from the literature. In this paper, we describe the possibility of umbelliferone transformation to other derivatives...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/30100629/solution-based-low-temperature-synthesis-of-germanium-nanorods-and-nanowires
#18
Patrik Pertl, Michael S Seifner, Christopher Herzig, Andreas Limbeck, Masiar Sistani, Alois Lugstein, Sven Barth
The Ga-assisted formation of Ge nanorods and nanowires in solution has been demonstrated and a catalytic activity of the Ga seeds was observed. The synthesis of anisotropic single-crystalline Ge nanostructures was achieved at temperatures as low as 170 °C. Gallium not only serves as nucleation seed but is also incorporated in the Ge nanowires in higher concentrations than its thermodynamic solubility limit.
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/29983454/a-practical-guide-for-using-lithium-halocarbenoids-in-homologation-reactions
#19
Serena Monticelli, Marta Rui, Laura Castoldi, Giada Missere, Vittorio Pace
Lithium halocarbenoids are versatile reagents for accomplishing homologation processes. The fast α-elimination they suffer has been considered an important limitation for their extensive use. Herein, we present a series of practical considerations for an effective employment in the homologation of selected carbon electrophiles.
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/29983453/one-pot-synthesis-of-triazines-as-potential-agents-affecting-cell-differentiation
#20
Thomas Linder, Michael Schnürch, Marko D Mihovilovic
This paper outlines the synthesis of a number of structural analogs of 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid which represent compounds with potential cardiogenetic activity. A one-pot protocol was developed for swift functionalization of the 1,3,5-triazine core without the need of isolating intermediates. The developed route starts from readily available 2,4,6-trichloro-1,3,5-triazine, displacing the chlorine atoms sequentially by aryloxy, arylamino, or arylthio moieties to enable access to molecules with three different substituents of this type in good yields...
2018: Monatshefte Für Chemie
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