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Monatshefte Für Chemie

Renata Paprocka, Małgorzata Wiese-Szadkowska, Anna Helmin-Basa, Liliana Mazur, Jolanta Kutkowska, Jacek Michałkiewicz, Bożena Modzelewska-Banachiewicz, Leszek Pazderski
The series of new hydrazide derivatives were synthesized in reactions of N3 -substituted amidrazones with cyclic anhydrides as potential anti-inflammatory and antibacterial agents. The compounds were characterized by 1 H-13 C two-dimensional NMR techniques, which revealed the presence of two tautomeric forms in DMSO- d 6 solutions, while the molecular structure of one species was confirmed by single-crystal X-ray diffraction. The anti-inflammatory effects of hydrazides on peripheral blood mononuclear cells were experimentally evaluated...
2018: Monatshefte Für Chemie
Danuta Branowska, Justyna Ławecka, Mariusz Sobiczewski, Zbigniew Karczmarzyk, Waldemar Wysocki, Ewa Wolińska, Ewa Olender, Barbara Mirosław, Alicja Perzyna, Anna Bielawska, Krzysztof Bielawski
A new series of 1,2,4-triazine unsymmetrical disulfanes were prepared and evaluated as anticancer activity compounds against MCF-7 human breast cancer cells with some of them acting as low micromolar inhibitors. Evaluation of the cytotoxicity using an MTT assay, the inhibition of [3 H]-thymidine incorporation into DNA demonstrated that these products exhibit cytotoxic effects on breast cancer cells in vitro. The most effective compounds with 59 and 60 µM compared to chlorambucil with 47 µM were disulfanes bearing methyl and methoxy substituent in an aromatic ring...
2018: Monatshefte Für Chemie
Dorota Gugała-Fekner
The measurements of double-layer differential capacitance, zero charge potential, and surface tension at that potential allowed us to examine the adsorption properties of adenine on the mercury surface from the neat buffer solution, i.e., the acetate buffer at pH 5 and pH 6. The systems obtained at such pH values were close to physiological fluids in their characteristics. The adsorption energy and interaction constants were determined using Frumkin isotherm and virial isotherm. It was shown that the adenine molecule is adsorbed on the mercury electrode with its negative pole against the electrode surface...
2018: Monatshefte Für Chemie
Andrzej L Dawidowicz, Katarzyna Bernacik, Rafał Typek
Umbelliferone (7-hydroxycoumarin) is one of the most popular compounds of the coumarins family. This compound receives the attention of scientists due to its diverse bioactivities in a number of applications in various therapeutic fields. An interesting aspect of umbelliferone is its structural lability. The enzymatic degradation process of umbelliferone to its hydroxylated (esculetin), glucosylated (skimmin), and methylated (herniarin) derivatives is already known from the literature. In this paper, we describe the possibility of umbelliferone transformation to other derivatives...
2018: Monatshefte Für Chemie
Patrik Pertl, Michael S Seifner, Christopher Herzig, Andreas Limbeck, Masiar Sistani, Alois Lugstein, Sven Barth
The Ga-assisted formation of Ge nanorods and nanowires in solution has been demonstrated and a catalytic activity of the Ga seeds was observed. The synthesis of anisotropic single-crystalline Ge nanostructures was achieved at temperatures as low as 170 °C. Gallium not only serves as nucleation seed but is also incorporated in the Ge nanowires in higher concentrations than its thermodynamic solubility limit.
2018: Monatshefte Für Chemie
Serena Monticelli, Marta Rui, Laura Castoldi, Giada Missere, Vittorio Pace
Lithium halocarbenoids are versatile reagents for accomplishing homologation processes. The fast α-elimination they suffer has been considered an important limitation for their extensive use. Herein, we present a series of practical considerations for an effective employment in the homologation of selected carbon electrophiles.
2018: Monatshefte Für Chemie
Thomas Linder, Michael Schnürch, Marko D Mihovilovic
This paper outlines the synthesis of a number of structural analogs of 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid which represent compounds with potential cardiogenetic activity. A one-pot protocol was developed for swift functionalization of the 1,3,5-triazine core without the need of isolating intermediates. The developed route starts from readily available 2,4,6-trichloro-1,3,5-triazine, displacing the chlorine atoms sequentially by aryloxy, arylamino, or arylthio moieties to enable access to molecules with three different substituents of this type in good yields...
2018: Monatshefte Für Chemie
Joanna Fedorowicz, Jarosław Sączewski
This review is aimed to provide extensive survey of quinolones and fluoroquinolones for a variety of applications ranging from metal complexes and nanoparticle development to hybrid conjugates with therapeutic uses. The review covers the literature from the past 10 years with emphasis placed on new applications and mechanisms of pharmacological action of quinolone derivatives. The following are considered: metal complexes, nanoparticles and nanodrugs, polymers, proteins and peptides, NO donors and analogs, anionic compounds, siderophores, phosphonates, and prodrugs with enhanced lipophilicity, phototherapeutics, fluorescent compounds, triazoles, hybrid drugs, bis-quinolones, and other modifications...
2018: Monatshefte Für Chemie
Piotr Matczak
Theoretical quantum mechanical calculations have been carried out to establish the effect of surface vacancies on the adsorption of Pd and Pb atoms on the defective MgO(100) surface. The investigated defects included neutral, singly and doubly charged O and Mg vacancies on the (100) surface of MgO. These vacancies played the role of Fs n + and Vs n - ( n  = 0, 1, 2) adsorption centers for a single Pd or Pb atom. From the results of calculations, it is clear that the Pd- and Pb-atom adsorption at the Fs n + and Vs n - centers shows different characteristics than at the regular O2- and Mg2+ centers...
2018: Monatshefte Für Chemie
Rafał Frański, Błażej Gierczyk, Łukasz Popenda, Małgorzata Kasperkowiak, Tomasz Pędzinski
A commercially available biliverdin sample was analyzed by means of HPLC/ESI-MS and NMR spectroscopy. It was been found that beside the main IXα 5 Z ,10 Z ,15 Z isomer, the sample contains also the geometric isomer IXα 5 Z ,10 Z ,15 E. It was also found the isomers behave differentially upon "in-source" fragmentation in negative ion mode (in contrast to the their behavior upon "in-source" fragmentation in positive ion mode and to their behavior upon MS/MS fragmentation in both modes): the relative abundances of deprotonated molecules and fragment ions are significantly different for both isomers, which can be used as an analytical tool to differentiate between the isomers...
2018: Monatshefte Für Chemie
Izabela Jendrzejewska, Paweł Zajdel, Ewa Pietrasik, Zoja Barsova, Tomasz Goryczka
X-ray analysis confirmed that in all investigated samples, the active API (acetylsalicylic acid and ascorbic acid) was present. The values of the interplanar distance d hkl for the studied samples are in good accordance with those presented in the ICDD database. The intensities of the diffraction lines depend on the content of the component in the tested preparation. Therefore, different intensities of lines for the APIs were observed in the obtained diffraction patterns. Thermal analysis of the studied substances showed that during the thermal analysis, the following phenomena might occur: dehydration and (or) melting, crystalline transformation...
2018: Monatshefte Für Chemie
Dorota Wójcik-Pastuszka, Anna M Biedrawa, Dorota Haznar-Garbacz, Witold S Musiał
Tablets are often used in splitting process when the appropriated, registered dose is not available on the market or patients exhibit swallowing difficulties caused by the size of the tablet. The aim of the work was to assess the impact of physical division of tablets on the kinetics of in vitro gliclazide release from the intact and divided tablets. Gliclazide was released from prolonged release tablets containing 30 or 60 mg of the drug into a phosphate buffer, pH 7.4 and the amount of the drug in acceptor fluid was determined by UV-Vis spectrophotometry...
2018: Monatshefte Für Chemie
Anna Lisik, Anna Prescha, Levent E Cavlaz, Halina Grajeta, Witold Musiał
The atomic absorption spectrometry (AAS) method is one of the most accessible procedures for ferrous ions testing in various compositions including pharmaceutical preparations. The aim of the study was to develop and partially validate analytical method which could be an excellent alternative to the routine procedure performed within dissolution studies. Electric conductivity is simple, fast, and hassle-free method. The samples during dissolution process were measured using conductivity probe in entire dissolution assessment protocol...
2018: Monatshefte Für Chemie
Nikolaus Guttenberger, Thomas Schlatzer, Mario Leypold, Sebastian Tassoti, Rolf Breinbauer
In this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop new antibiotics via downregulation of phenazine biosynthesis.
2018: Monatshefte Für Chemie
Dennis Svatunek, Christoph Denk, Hannes Mikula
The tetrazine ligation is one of the fastest bioorthogonal ligations and plays a pivotal role in time-critical in vitro and in vivo applications. However, prediction of the reactivity of tetrazines in inverse electron demand Diels-Alder-initiated ligation reactions is not straight-forward. Commonly used tools such as frontier molecular orbital theory only give qualitative and often even wrong results. Applying density functional theory, we have been able to develop a simple computational method for the prediction of the reactivity of aryl/alkyl-substituted tetrazines in inverse electron demand Diels-Alder reactions...
2018: Monatshefte Für Chemie
Mrinmay Mandal, Manuela List, Ian Teasdale, Günther Redhammer, Debashis Chakraborty, Uwe Monkowius
The preparation, structural characterization, luminescence, and catalytic activity of three palladium(II) complexes bearing imino phenoxide ligands are reported. The X-ray studies revealed that the complexes are mononuclear with palladium centres coordinated in a square-planar coordination environment. Two of the complexes are emissive in solution at room temperature. The catalytic activities towards the ring-opening polymerization of rac -lactide ( rac -LA) were tested. Polymers with moderate molecular weights and relatively broad dispersity ( Ð ) were obtained...
2018: Monatshefte Für Chemie
Michael Haas, Sabrina Gonglach, Stefan Müllegger, Wolfgang Schöfberger
We report the chemical synthesis and characterization of the stable 5,15-bis(pentafluorophenyl)-10-(trimethylsilylethynyl)corrole which serves as a precursor for the subsequent in situ sila-Sonogashira-cross-coupling reaction and metalation with copper(II) acetate. Under ambient conditions and a common catalyst system the reaction with 1-iodopyrene occurred within five hours. Due to the direct conjugation of the 18π-electronic system of the corrole macrocycle over the alkynyl group to the pyrene moiety the optical transitions in the Soret (B-) band Q-band region are significantly altered...
2018: Monatshefte Für Chemie
Volkmar Trommer, Fabian Fischer, Marko Hapke
The concise synthesis of a novel chiral diyne substrate for the assembly of chiral naphthylpyridines was described and different conditions for the cobalt-catalyzed co-cyclotrimerization with nitriles investigated. The products are novel naphthylpyridines possessing configurationally stable biaryl axes.
2018: Monatshefte Für Chemie
Miran Lemmerer, Christopher J Teskey, Daniel Kaiser, Nuno Maulide
A regioselective synthesis of pyridines by the addition of malonate anions to pyridine N -oxide derivatives, which have been activated by trifluoromethanesulfonic anhydride, is reported. The reaction selectively affords either 2- or 4-substituted pyridines in good yields.
2018: Monatshefte Für Chemie
Christina Gaunersdorfer, Mario Waser
Sultones, the cyclic esters of hydroxyl sulfonic acids, are a fascinating class of heterocycles and the recent years have witnessed an increasing interest in these molecules, especially in six-ring δ-sultones. The importance of these compounds is either because of their biological properties themselves or due to their versatility as intermediates in more complex target syntheses. Accordingly, the development of new synthesis methods to access δ-sultones is an important and rewarding task which we wish to highlight in this review...
2018: Monatshefte Für Chemie
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