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Behavior Genetics

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https://www.readbyqxmd.com/read/29164405/genetic-variance-in-homophobia-evidence-from-self-and-peer-reports
#1
Alexandra Zapko-Willmes, Christian Kandler
The present twin study combined self- and peer assessments of twins' general homophobia targeting gay men in order to replicate previous behavior genetic findings across different rater perspectives and to disentangle self-rater-specific variance from common variance in self- and peer-reported homophobia (i.e., rater-consistent variance). We hypothesized rater-consistent variance in homophobia to be attributable to genetic and nonshared environmental effects, and self-rater-specific variance to be partially accounted for by genetic influences...
November 21, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29150722/cross-lagged-analysis-of-interplay-between-differential-traits-in-sibling-pairs-validation-and-application-to-parenting-behavior-and-adhd-symptomatology
#2
Arden Moscati, Brad Verhulst, Kevin McKee, Judy Silberg, Lindon Eaves
Understanding the factors that contribute to behavioral traits is a complex task, and partitioning variance into latent genetic and environmental components is a useful beginning, but it should not also be the end. Many constructs are influenced by their contextual milieu, and accounting for background effects (such as gene-environment correlation) is necessary to avoid bias. This study introduces a method for examining the interplay between traits, in a longitudinal design using differential items in sibling pairs...
November 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29150721/adaptive-snp-set-association-testing-in-generalized-linear-mixed-models-with-application-to-family-studies
#3
Jun Young Park, Chong Wu, Saonli Basu, Matt McGue, Wei Pan
In genome-wide association studies (GWAS), it has been increasingly recognized that, as a complementary approach to standard single SNP analyses, it may be beneficial to analyze a group of functionally related SNPs together. Among the existent population-based SNP-set association tests, two adaptive tests, the aSPU test and the aSPUpath test, offer a powerful and general approach at the gene- and pathway-levels by data-adaptively combining the results across multiple SNPs (and genes) such that high statistical power can be maintained across a wide range of scenarios...
November 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29127570/behavior-genetics-association-47th-annual-meeting-abstracts
#4
(no author information available yet)
No abstract text is available yet for this article.
November 11, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29098497/the-impact-of-variation-in-twin-relatedness-on-estimates-of-heritability-and-environmental-influences
#5
Chang Liu, Peter C M Molenaar, Jenae M Neiderhiser
By taking advantage of the natural variation in genetic relatedness among identical (monozygotic: MZ) and fraternal (dizygotic: DZ) twins, twin studies are able to estimate genetic and environmental contributions to complex human behaviors. Recently concerns have been raised about the accuracy of twin studies in light of findings of genetic and epigenetic changes in twins. One of the concerns raised is that MZ twins are not 100% genetically and epigenetically similar because they show variations in their genomes and epigenomes leading to inaccurate estimates of heritability...
November 2, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29098496/partitioning-phenotypic-variance-due-to-parent-of-origin-effects-using-genomic-relatedness-matrices
#6
Charles Laurin, Gabriel Cuellar-Partida, Gibran Hemani, George Davey Smith, Jian Yang, David M Evans
We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals' phased genotypes. Genome-wide SNP data from parent child duos or trios is required to obtain relatedness matrices indexing the parental origin of offspring alleles, as well as offspring phenotype data to partition the trait variation into variance components...
November 2, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29098495/persistent-one-way-walking-in-a-circular-arena-in-drosophila-melanogaster-canton-s-strain
#7
Chengfeng Xiao, Shuang Qiu, R Meldrum Robertson
We describe persistent one-way walking of Drosophila melanogaster in a circular arena. Wild-type Canton-S adult flies walked in one direction, counter-clockwise or clockwise, for minutes, whereas white-eyed mutant [Formula: see text] changed directions frequently. Locomotion in the circular arena could be classified into four components: counter-clockwise walking, clockwise walking, nondirectional walking and pausing. Genetic analysis revealed that while wild-type genetic background was associated with reduced directional change and reduced numbers of one-way (including counter-clockwise and clockwise) and nondirectional walks, the white ([Formula: see text]) locus promoted persistent one-way walking by increasing the maximal duration of one-way episodes...
November 2, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29043520/an-extended-twin-pedigree-study-of-neuroticism-in-the-netherlands-twin-register
#8
Dorret I Boomsma, Quinta Helmer, Harold A Nieuwboer, Jouke Jan Hottenga, Marleen H de Moor, Stéphanie M van den Berg, Gareth E Davies, Jacqueline M Vink, Maarten J Schouten, Conor V Dolan, Gonneke Willemsen, Meike Bartels, Toos C E M van Beijsterveldt, Lannie Ligthart, Eco J de Geus
For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores...
October 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29043519/announcement-of-the-fulker-award-for-a-paper-published-in-behavior-genetics-volume-46-2016
#9
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29043518/referees-for-volume-47
#10
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29043517/awards-presented-at-the-47th-annual-meeting-of-the-behavior-genetics-association-thursday-july-1st-oslo-norway
#11
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29043516/minutes-of-the-annual-business-meeting-of-the-members-of-the-behavior-genetics-association-wednesday-june-30-2017-12-00-1-30%C3%A2-pm-oslo-norway
#12
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29043515/the-2018-international-workshop-on-statistical-genetic-methods-for-human-complex-traits-formerly-the-methodology-of-twin-and-family-studies-introductory-workshop-march-5th-march-9th-2018
#13
https://www.readbyqxmd.com/read/28948422/effects-of-social-attitude-change-on-smoking-heritability
#14
Laura Mezquita, Juan F Sánchez-Romera, Manuel I Ibáñez, José J Morosoli, Lucía Colodro-Conde, Generós Ortet, Juan R Ordoñana
Societal attitudes and norms to female smoking changed in Spain in the mid-twentieth century from a restrictive to a tolerant, and an even pro-smoking, posture, while social attitudes remained stable for males. We explored whether this difference in gender-related social norms influenced the heritability of two tobacco use measures: lifetime smoking and number of years smoking. We used a population-based sample of 2285 twins (mean age = 55.78; SD = 7.45; 58% females) whose adolescence began between the mid-1950s and the early 1980s...
September 25, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28936718/identification-of-candidate-genes-for-generalized-tonic-clonic-seizures-in-noda-epileptic-rat
#15
Takashi Kuramoto, Birger Voigt, Satoshi Nakanishi, Kazuhiro Kitada, Tadashi Nakamura, Kaori Wakamatsu, Minako Yoshihara, Mikita Suyama, Risa Uemura, Miyuu Tanaka, Mitsuru Kuwamura, Saki Shimizu, Yukihiro Ohno, Masashi Sasa, Tadao Serikawa
The Noda epileptic rat (NER) exhibits generalized tonic-clonic seizures (GTCS). A genetic linkage analysis identified two GTCS-associated loci, Ner1 on Chr 1 and Ner3 on Chr 5. The wild-type Ner1 and Ner3 alleles suppressed GTCS when combined in double-locus congenic lines, but not when present in single-locus congenic lines. Global expression analysis revealed that cholecystokinin B receptor (Cckbr) and suppressor of tumorigenicity 5 (St5), which map within Ner1, and PHD finger protein 24 (Phf24), which maps within Ner3, were significantly downregulated in NER...
September 21, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28921187/moderation-of-genetic-influences-on-alcohol-involvement-by-rural-residency-among-adolescents-results-from-the-1962-national-merit-twin-study
#16
Christal N Davis, Shanaliz S Natta, Wendy S Slutske
Adolescents in rural and urban areas may experience different levels of environmental restrictions on alcohol use, with those in rural areas experiencing greater monitoring and less access to alcohol. Such restrictions may limit expression of genetic vulnerability for alcohol use, resulting in a gene-environment interaction (G × E). This phenomenon has previously been reported in Finnish and Minnesota adolescents. The current study used data from 839 same-sex twin pairs from the 1962 National Merit Scholarship Qualifying Test to determine whether the G × E interaction would be evident in this earlier time period...
September 18, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28879499/impaired-dopamine-dependent-locomotory-behavior-of-c-elegans-neuroligin-mutants-depends-on-the-catechol-o-methyltransferase-comt-4
#17
Ángel Rodríguez-Ramos, M Mar Gámez-Del-Estal, Montserrat Porta-de-la-Riva, Julián Cerón, Manuel Ruiz-Rubio
Neurexins and neuroligins are neuronal membrane adhesion molecules that have been involved in neuropsychiatric and neurodevelopmental disorders. The nrx-1 and nlg-1 genes of Caenorhabditis elegans encode NRX-1 and NLG-1, orthologue proteins of human neurexins and neuroligins, respectively. Dopaminergic and serotoninergic signalling control the locomotory rate of the nematode. When well-fed animals are transferred to a plate with food (bacterial lawn), they reduce the locomotory rate. This behavior, which depends on dopamine, is known as basal slowing response (BSR)...
September 6, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28879484/acet-an-r-package-for-estimating-dynamic-heritability-and-comparing-twin-models
#18
Liang He, Janne Pitkäniemi, Karri Silventoinen, Mikko J Sillanpää
Estimating dynamic effects of age on the genetic and environmental variance components in twin studies may contribute to the investigation of gene-environment interactions, and may provide more insights into more accurate and powerful estimation of heritability. Existing parametric models for estimating dynamic variance components suffer from various drawbacks such as limitation of predefined functions. We present ACEt, an R package for fast estimating dynamic variance components and heritability that may change with respect to age or other moderators...
September 6, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28822047/the-quinpirole-hypolocomotive-effects-are-strain-and-route-of-administration-dependent-in-shr-and-sla16-isogenic-rats
#19
R A N Pértile, M E Corvino, R C N Marchette, E Pavesi, J Cavalli, A Ramos, G S Izídio
The SHR and SLA16 inbred strains present behavioral differences in anxiety/emotionality that could be under the influence of dopaminergic neurotransmission. In order to investigate the role of D2 receptors in modulating such differences, an agonist (quinpirole) and an antagonist (haloperidol) of this receptor were administered, either via systemic injection (IP), or microinjected into the ventral area of the hippocampus (vHIP). Quinpirole and haloperidol IP decreased locomotor activity, only in SLA16 rats in the open-field (OF), and in both strains in the elevated plus-maze (EPM)...
September 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28785901/age-at-menarche-and-time-spent-in-education-a-mendelian-randomization-study
#20
D Gill, F Del Greco M, T M Rawson, P Sivakumaran, A Brown, N A Sheehan, C Minelli
Menarche signifies the primary event in female puberty and is associated with changes in self-identity. It is not clear whether earlier puberty causes girls to spend less time in education. Observational studies on this topic are likely to be affected by confounding environmental factors. The Mendelian randomization (MR) approach addresses these issues by using genetic variants (such as single nucleotide polymorphisms, SNPs) as proxies for the risk factor of interest. We use this technique to explore whether there is a causal effect of age at menarche on time spent in education...
September 2017: Behavior Genetics
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