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Behavior Genetics

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https://www.readbyqxmd.com/read/28921187/moderation-of-genetic-influences-on-alcohol-involvement-by-rural-residency-among-adolescents-results-from-the-1962-national-merit-twin-study
#1
Christal N Davis, Shanaliz S Natta, Wendy S Slutske
Adolescents in rural and urban areas may experience different levels of environmental restrictions on alcohol use, with those in rural areas experiencing greater monitoring and less access to alcohol. Such restrictions may limit expression of genetic vulnerability for alcohol use, resulting in a gene-environment interaction (G × E). This phenomenon has previously been reported in Finnish and Minnesota adolescents. The current study used data from 839 same-sex twin pairs from the 1962 National Merit Scholarship Qualifying Test to determine whether the G × E interaction would be evident in this earlier time period...
September 18, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28879499/impaired-dopamine-dependent-locomotory-behavior-of-c-elegans-neuroligin-mutants-depends-on-the-catechol-o-methyltransferase-comt-4
#2
Ángel Rodríguez-Ramos, M Mar Gámez-Del-Estal, Montserrat Porta-de-la-Riva, Julián Cerón, Manuel Ruiz-Rubio
Neurexins and neuroligins are neuronal membrane adhesion molecules that have been involved in neuropsychiatric and neurodevelopmental disorders. The nrx-1 and nlg-1 genes of Caenorhabditis elegans encode NRX-1 and NLG-1, orthologue proteins of human neurexins and neuroligins, respectively. Dopaminergic and serotoninergic signalling control the locomotory rate of the nematode. When well-fed animals are transferred to a plate with food (bacterial lawn), they reduce the locomotory rate. This behavior, which depends on dopamine, is known as basal slowing response (BSR)...
September 6, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28879484/acet-an-r-package-for-estimating-dynamic-heritability-and-comparing-twin-models
#3
Liang He, Janne Pitkäniemi, Karri Silventoinen, Mikko J Sillanpää
Estimating dynamic effects of age on the genetic and environmental variance components in twin studies may contribute to the investigation of gene-environment interactions, and may provide more insights into more accurate and powerful estimation of heritability. Existing parametric models for estimating dynamic variance components suffer from various drawbacks such as limitation of predefined functions. We present ACEt, an R package for fast estimating dynamic variance components and heritability that may change with respect to age or other moderators...
September 6, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28822047/the-quinpirole-hypolocomotive-effects-are-strain-and-route-of-administration-dependent-in-shr-and-sla16-isogenic-rats
#4
R A N Pértile, M E Corvino, R C N Marchette, E Pavesi, J Cavalli, A Ramos, G S Izídio
The SHR and SLA16 inbred strains present behavioral differences in anxiety/emotionality that could be under the influence of dopaminergic neurotransmission. In order to investigate the role of D2 receptors in modulating such differences, an agonist (quinpirole) and an antagonist (haloperidol) of this receptor were administered, either via systemic injection (IP), or microinjected into the ventral area of the hippocampus (vHIP). Quinpirole and haloperidol IP decreased locomotor activity, only in SLA16 rats in the open-field (OF), and in both strains in the elevated plus-maze (EPM)...
August 18, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28785901/age-at-menarche-and-time-spent-in-education-a-mendelian-randomization-study
#5
D Gill, F Del Greco M, T M Rawson, P Sivakumaran, A Brown, N A Sheehan, C Minelli
Menarche signifies the primary event in female puberty and is associated with changes in self-identity. It is not clear whether earlier puberty causes girls to spend less time in education. Observational studies on this topic are likely to be affected by confounding environmental factors. The Mendelian randomization (MR) approach addresses these issues by using genetic variants (such as single nucleotide polymorphisms, SNPs) as proxies for the risk factor of interest. We use this technique to explore whether there is a causal effect of age at menarche on time spent in education...
August 9, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28780665/sum-scores-in-twin-growth-curve-models-practicality-versus-bias
#6
Justin M Luningham, Daniel B McArtor, Meike Bartels, Dorret I Boomsma, Gitta H Lubke
To study behavioral or psychiatric phenotypes, multiple indices of the behavior or disorder are often collected that are thought to best reflect the phenotype. Combining these items into a single score (e.g. a sum score) is a simple and practical approach for modeling such data, but this simplicity can come at a cost in longitudinal studies, where the relevance of individual items often changes as a function of age. Such changes violate the assumptions of longitudinal measurement invariance (MI), and this violation has the potential to obfuscate the interpretation of the results of latent growth models fit to sum scores...
August 5, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28776207/long-term-follow-up-of-cognition-and-mental-health-in-adult-phenylketonuria-a-pku-cobeso-study
#7
Rianne Jahja, Francjan J van Spronsen, Leo M J de Sonneville, Jaap J van der Meere, Annet M Bosch, Carla E M Hollak, M Estela Rubio-Gozalbo, Martijn C G J Brouwers, Floris C Hofstede, Maaike C de Vries, Mirian C H Janssen, Ans T van der Ploeg, Janneke G Langendonk, Stephan C J Huijbregts
Cognitive and mental health problems in individuals with the inherited metabolic disorder phenylketonuria (PKU) have often been associated with metabolic control and its history. For the present study executive functioning (EF) was assessed in 21 PKU patients during childhood (T1, mean age 10.4 years, SD = 2.0) and again in adulthood (T2, mean age 25.8 years, SD = 2.3). At T2 additional assessments of EF in daily life and mental health were performed. Childhood (i.e. 0-12 years) blood phenylalanine was significantly related to cognitive flexibility, executive motor control, EF in daily life and mental health in adulthood (i...
August 3, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28714052/conservation-of-phenotypes-in-the-roman-high-and-low-avoidance-rat-strains-after-embryo-transfer
#8
Cristóbal Río-Álamos, Cristina Gerbolés, Carles Tapias-Espinosa, Daniel Sampedro-Viana, Ignasi Oliveras, Ana Sánchez-González, Toni Cañete, Gloria Blázquez, María Del Mar López, Carlos Baldellou, Pedro J Otaegui, Adolf Tobeña, Alberto Fernández-Teruel
The Roman high- (RHA-I) and low-avoidance (RLA-I) rat strains are bi-directionally bred for their good versus non-acquisition of two-way active avoidance, respectively. They have recently been re-derived through embryo transfer (ET) to Sprague-Dawley females to generate specific pathogen free (SPF) RHA-I/RLA-I rats. Offspring were phenotyped at generations 1 (G1, born from Sprague-Dawley females), 3 and 5 (G3 and G5, born from RHA-I and RLA-I from G2-G4, respectively), and compared with generation 60 from our non-SPF colony...
July 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28714051/contributions-of-genes-and-environment-to-developmental-change-in-alcohol-use
#9
E C Long, B Verhulst, S H Aggen, K S Kendler, N A Gillespie
The precise nature of how genetic and environmental risk factors influence changes in alcohol use (AU) over time has not yet been investigated. Therefore, the aim of the present study is to examine the nature of longitudinal changes in these risk factors to AU from mid-adolescence through young adulthood. Using a large sample of male twins, we compared five developmental models that each makes different predictions regarding the longitudinal changes in genetic and environmental risks for AU. The best-fitting model indicated that genetic influences were consistent with a gradual growth in the liability to AU, whereas unique environmental risk factors were consistent with an accumulation of risks across time...
July 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28711986/single-nucleotide-polymorphisms-associated-with-reading-ability-show-connection-to-socio-economic-outcomes
#10
Michelle Luciano, Saskia P Hagenaars, Simon R Cox, William David Hill, Gail Davies, Sarah E Harris, Ian J Deary, David M Evans, Nicholas G Martin, Margaret J Wright, Timothy C Bates
Impairments in reading and in language have negative consequences on life outcomes, but it is not known to what extent genetic effects influence this association. We constructed polygenic scores for difficulties with language and learning to read from genome-wide data in ~6,600 children, adolescents and young adults, and tested their association with health, socioeconomic outcomes and brain structure measures collected in adults (maximal N = 111,749). Polygenic risk of reading difficulties was associated with reduced income, educational attainment, self-rated health and verbal-numerical reasoning (p < 0...
July 15, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28711985/higher-rates-of-dz-twinning-in-a-twenty-first-century-birth-cohort
#11
Sally Ann Rhea, Robin P Corley, Andrew C Heath, William G Iacono, Michael C Neale, John K Hewitt
The Colorado Twin Registry is a population based registry initiated in 1984 with the involvement of the Colorado Department of Health, Division of Vital Statistics. Recruitment includes birth cohorts several years prior to 1984 and all subsequent years. As part of a recent evaluation of Colorado birth records for the years 2006 through 2008 we became aware of a shifting trend in the proportion of MZ and DZ twins in the Colorado population. Historically (Bulmer 1970 The biology of twinning in man, Clarendon, Oxford) we have expected a 1/3, 1/3, 1/3 ratio of MZ, same-sex DZ and opposite sex DZ twins in Caucasian populations...
July 15, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28551760/genetic-and-environmental-influences-on-longitudinal-trajectories-of-functional-biological-age-comparisons-across-gender
#12
Deborah Finkel, Ola Sternäng, Åke Wahlin
We used an alternate age variable, functional biological age (fBioAge), which was based on performance on functional body measures. The aim was to examine development of fBioAge across the adult life span, and to also examine potential gender differences and genetic and environmental influences on change with age. We used longitudinal data (n = 740; chronological age (ChronAge) range 45-85 at baseline) from the Swedish Adoption/Twin Study of Aging. The rate of increase in fBioAge was twice as fast after ChronAge 75 than before...
July 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28466236/pleiotropic-effects-of-ddt-resistance-on-male-size-and-behaviour
#13
Wayne G Rostant, Jemima Bowyer, Jack Coupland, James Facey, David J Hosken, Nina Wedell
Understanding the evolution and spread of insecticide resistance requires knowing the relative fitness of resistant organisms. In the absence of insecticides, resistance is predicted to be costly. The Drosophila melanogaster DDT resistance allele (DDT-R) is associated with a male mating cost. This could be because resistant males are generally smaller, but DDT-R may also alter courtship behaviours. Here we tested for body size and courtship effects of DDT-R on mating success in competitive and non-competitive mating trials respectively...
July 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28466235/cannabis-and-depression-a-twin-model-approach-to-co-morbidity
#14
M Smolkina, K I Morley, F Rijsdijk, A Agrawal, J E Bergin, E C Nelson, D Statham, N G Martin, M T Lynskey
Cannabis use disorder (CUD) co-occurs with major depressive disorder (MDD) more frequently than would be expected by chance. However, studies to date have not produced a clear understanding of the mechanisms underlying this co-morbidity. Genetically informative studies can add valuable insight to this problem, as they allow the evaluation of competing models of co-morbidity. This study uses data from the Australian Twin Registry to compare 13 co-morbidity twin models initially proposed by Neale and Kendler (Am J Hum Genet 57:935-953, 1995)...
July 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28585192/rsk2-knockout-affects-emotional-behavior-in-the-intellicage
#15
Matthias Fischer, Victoria Cabello, Sandy Popp, Sven Krackow, Leif Hommers, Jürgen Deckert, Klaus-Peter Lesch, Angelika G Schmitt-Böhrer
Ribosomal s6 kinase 2 is a growth factor activated serine/threonine kinase and member of the ERK signaling pathway. Mutations in the Rsk2 gene cause Coffin-Lowry syndrome, a rare syndromic form of intellectual disability. The Rsk2 KO mouse model was shown to have learning and memory defects. We focused on the investigation of the emotional behavioral phenotype of Rsk2 KO mice mainly in the IntelliCage. They exhibited an anti-depressive, sucrose reward seeking phenotype and showed reduced anxiety. Spontaneous activity was increased in some conventional tests...
June 6, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28551761/a-family-based-study-of-the-association-between-labor-induction-and-offspring-attention-deficit-hyperactivity-disorder-and-low-academic-achievement
#16
Kelsey K Wiggs, Martin E Rickert, Sonia Hernandez-Diaz, Brian T Bateman, Catarina Almqvist, Henrik Larsson, Paul Lichtenstein, Anna Sara Oberg, Brian M D'Onofrio
The current study examined associations between labor induction and both (1) offspring attention-deficit hyperactivity disorder (ADHD) diagnosis in a Swedish birth cohort born 1992-2005 (n = 1,085,008) and (2) indices of offspring low academic achievement in a sub-cohort born 1992-1997 (n = 489,196). Associations were examined in the entire sample (i.e., related and unrelated individuals) with adjustment for measured covariates and, in order to account for unmeasured confounders shared within families, within differentially exposed cousins and siblings...
May 27, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28474239/erratum-to-publication-trends-over-55-years-of-behavioral-genetic-research
#17
Ziada Ayorech, Saskia Selzam, Emily Smith-Woolley, Valerie S Knopik, Jenae M Neiderhiser, John C DeFries, Robert Plomin
No abstract text is available yet for this article.
May 4, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28299468/gw-sem-a-statistical-package-to-conduct-genome-wide-structural-equation-modeling
#18
Brad Verhulst, Hermine H Maes, Michael C Neale
Improving the accuracy of phenotyping through the use of advanced psychometric tools will increase the power to find significant associations with genetic variants and expand the range of possible hypotheses that can be tested on a genome-wide scale. Multivariate methods, such as structural equation modeling (SEM), are valuable in the phenotypic analysis of psychiatric and substance use phenotypes, but these methods have not been integrated into standard genome-wide association analyses because fitting a SEM at each single nucleotide polymorphism (SNP) along the genome was hitherto considered to be too computationally demanding...
May 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28238197/phenotypic-and-genetic-relationship-between-bmi-and-drinking-in-a-sample-of-uk-adults
#19
Amanda G Wills, Luke M Evans, Christian Hopfer
The health impairments derived from both alcoholism and obesity are well known. However, reports that relate increased alcohol use with increased measures of obesity have been mixed in their findings, especially with respect to genetic factors that could potentially link these two behaviors. Here, using a large sample of adults from the UK (n ≈ 113,000), we report both the observed and genetic correlations between BMI (kg/m(2)) and two measures of alcohol use: reported quantity (drinks per week) and frequency of use (from never to daily)...
May 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28191586/attention-deficit-hyperactivity-disorder-symptoms-and-low-educational-achievement-evidence-supporting-a-causal-hypothesis
#20
Eveline L de Zeeuw, Catharina E M van Beijsterveldt, Erik A Ehli, Eco J C de Geus, Dorret I Boomsma
Attention Deficit Hyperactivity Disorder (ADHD) and educational achievement are negatively associated in children. Here we test the hypothesis that there is a direct causal effect of ADHD on educational achievement. The causal effect is tested in a genetically sensitive design to exclude the possibility of confounding by a third factor (e.g. genetic pleiotropy) and by comparing educational achievement and secondary school career in children with ADHD who take or do not take methylphenidate. Data on ADHD symptoms, educational achievement and methylphenidate usage were available in a primary school sample of ~10,000 12-year-old twins from the Netherlands Twin Register...
May 2017: Behavior Genetics
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