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Behavior Genetics

Chelsea R Kasten, Yanping Zhang, Ken Mackie, Stephen L Boehm
Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single 10 mg/kg THC dose in the open field. Selection for THC-locomotor sensitivity was moderately heritable, with the greatest estimates of heritability seen in females from the F2 to S3 generations...
March 17, 2018: Behavior Genetics
Sophie van der Sluis, César-Reyer Vroom, Conor V Dolan
No abstract text is available yet for this article.
February 21, 2018: Behavior Genetics
Fazil Aliev, Jessica E Salvatore, Arpana Agrawal, Laura Almasy, Grace Chan, Howard J Edenberg, Victor Hesselbrock, Samuel Kuperman, Jacquelyn Meyers, Danielle M Dick
The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation...
February 21, 2018: Behavior Genetics
Tinca J C Polderman, Baudewijntje P C Kreukels, Michael S Irwig, Lauren Beach, Yee-Ming Chan, Eske M Derks, Isabel Esteva, Jesse Ehrenfeld, Martin Den Heijer, Danielle Posthuma, Lewis Raynor, Amy Tishelman, Lea K Davis
The American Psychological Association defines gender identity as, "A person's deeply-felt, inherent sense of being a boy, a man, or a male; a girl, a woman, or a female; or an alternative gender (e.g., genderqueer, gender nonconforming, gender neutral) that may or may not correspond to a person's sex assigned at birth or to a person's primary or secondary sex characteristics" (American Psychological Association, Am Psychol 70(9):832-864, 2015). Here we review the evidence that gender identity and related socially defined gender constructs are influenced in part by innate factors including genes...
February 19, 2018: Behavior Genetics
Spencer B Huggett, Alexander S Hatoum, John K Hewitt, Michael C Stallings
We investigated the etiological role of genetic and environmental influences for two milestones of tobacco and alcohol use: age of initiation, and speed of progression to dependence (latency). Study participants included 1352 monozygotic and 1422 dizygotic twins (mean age at assessment = 24.31). Earlier ages of initiation significantly increased the likelihood of developing dependence, but were associated with longer dependence latencies for tobacco and alcohol. Latencies to dependence were heritable traits for tobacco (a2 = 0...
February 9, 2018: Behavior Genetics
Yayouk E Willems, Conor V Dolan, Catharina E M van Beijsterveldt, Eveline L de Zeeuw, Dorret I Boomsma, Meike Bartels, Catrin Finkenauer
This study used a theoretically-derived set of items of the Achenbach System of Empirically Based Assessment to develop the Achenbach Self-Control Scale (ASCS) for 7-16 year olds. Using a large dataset of over 20,000 children, who are enrolled in the Netherlands Twin Register, we demonstrated the psychometric properties of the ASCS for parent-, self- and teacher-report by examining internal and criterion validity, and inter-rater and test-retest reliability. We found associations between the ASCS and measures of well-being, educational achievement, and substance use...
February 5, 2018: Behavior Genetics
Soo Hyun Rhee, Naomi P Friedman, Ashley K Smith Watts, Robin P Corley, John K Hewitt, JoAnn Robinson, Carolyn Zahn-Waxler
Lower self-control is a significant correlate or predictor of a wide range of adult outcomes, and this association may be due to more general tendencies toward childhood externalizing problems. The present study examined the association between toddlerhood self-control expressed within a "don't" compliance task (at 14-36 months) and later externalizing problems (parent-reported externalizing problems from age 4 to 12 years, teacher-reported externalizing problems from age 7 to 12 years, and self-reported conduct disorder symptoms at age 17 years) in a longitudinal, genetically informative study...
January 3, 2018: Behavior Genetics
Alexandra Zapko-Willmes, Christian Kandler
The present twin study combined self- and peer assessments of twins' general homophobia targeting gay men in order to replicate previous behavior genetic findings across different rater perspectives and to disentangle self-rater-specific variance from common variance in self- and peer-reported homophobia (i.e., rater-consistent variance). We hypothesized rater-consistent variance in homophobia to be attributable to genetic and nonshared environmental effects, and self-rater-specific variance to be partially accounted for by genetic influences...
January 2018: Behavior Genetics
Jun Young Park, Chong Wu, Saonli Basu, Matt McGue, Wei Pan
In genome-wide association studies (GWAS), it has been increasingly recognized that, as a complementary approach to standard single SNP analyses, it may be beneficial to analyze a group of functionally related SNPs together. Among the existent population-based SNP-set association tests, two adaptive tests, the aSPU test and the aSPUpath test, offer a powerful and general approach at the gene- and pathway-levels by data-adaptively combining the results across multiple SNPs (and genes) such that high statistical power can be maintained across a wide range of scenarios...
January 2018: Behavior Genetics
Dimitri van der Linden, Julie A Schermer, Eveline de Zeeuw, Curtis S Dunkel, Keri A Pekaar, Arnold B Bakker, Philip A Vernon, K V Petrides
A previous meta-analysis (Van der Linden et al., Psychol Bull 143:36-52, 2017) showed that the General Factor of Personality (GFP) overlaps with ability as well as trait emotional intelligence (EI). The correlation between trait EI and the GFP was so high (ρ = 0.88) in that meta-analysis that these two may be considered virtually identical constructs. The present study builds on these findings by examining whether the strong phenotypic correlation between the GFP and trait EI has a genetic component. In a sample of monozygotic and dizygotic twins, the heritability estimates for the GFP and trait EI were 53 and 45%, respectively...
December 20, 2017: Behavior Genetics
Arden Moscati, Brad Verhulst, Kevin McKee, Judy Silberg, Lindon Eaves
Understanding the factors that contribute to behavioral traits is a complex task, and partitioning variance into latent genetic and environmental components is a useful beginning, but it should not also be the end. Many constructs are influenced by their contextual milieu, and accounting for background effects (such as gene-environment correlation) is necessary to avoid bias. This study introduces a method for examining the interplay between traits, in a longitudinal design using differential items in sibling pairs...
November 17, 2017: Behavior Genetics
(no author information available yet)
No abstract text is available yet for this article.
November 11, 2017: Behavior Genetics
Chang Liu, Peter C M Molenaar, Jenae M Neiderhiser
By taking advantage of the natural variation in genetic relatedness among identical (monozygotic: MZ) and fraternal (dizygotic: DZ) twins, twin studies are able to estimate genetic and environmental contributions to complex human behaviors. Recently concerns have been raised about the accuracy of twin studies in light of findings of genetic and epigenetic changes in twins. One of the concerns raised is that MZ twins are not 100% genetically and epigenetically similar because they show variations in their genomes and epigenomes leading to inaccurate estimates of heritability...
November 2, 2017: Behavior Genetics
Charles Laurin, Gabriel Cuellar-Partida, Gibran Hemani, George Davey Smith, Jian Yang, David M Evans
We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals' phased genotypes. Genome-wide SNP data from parent child duos or trios is required to obtain relatedness matrices indexing the parental origin of offspring alleles, as well as offspring phenotype data to partition the trait variation into variance components...
November 2, 2017: Behavior Genetics
Chengfeng Xiao, Shuang Qiu, R Meldrum Robertson
We describe persistent one-way walking of Drosophila melanogaster in a circular arena. Wild-type Canton-S adult flies walked in one direction, counter-clockwise or clockwise, for minutes, whereas white-eyed mutant [Formula: see text] changed directions frequently. Locomotion in the circular arena could be classified into four components: counter-clockwise walking, clockwise walking, nondirectional walking and pausing. Genetic analysis revealed that while wild-type genetic background was associated with reduced directional change and reduced numbers of one-way (including counter-clockwise and clockwise) and nondirectional walks, the white ([Formula: see text]) locus promoted persistent one-way walking by increasing the maximal duration of one-way episodes...
November 2, 2017: Behavior Genetics
Dorret I Boomsma, Quinta Helmer, Harold A Nieuwboer, Jouke Jan Hottenga, Marleen H de Moor, Stéphanie M van den Berg, Gareth E Davies, Jacqueline M Vink, Maarten J Schouten, Conor V Dolan, Gonneke Willemsen, Meike Bartels, Toos C E M van Beijsterveldt, Lannie Ligthart, Eco J de Geus
For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores...
October 17, 2017: Behavior Genetics
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Behavior Genetics
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