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Laboratory Medicine

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https://www.readbyqxmd.com/read/27794527/the-challenges-of-daratumumab-in-transfusion-medicine
#1
REVIEW
Michael F Dizon
The field of transfusion medicine has evolved rapidly in recent years, but the central principle of transfusion is still simple, namely, the antigen-antibody interaction. Daratumumab (DARA), a monoclonal antibody (MoAb), was developed to treat relapsed/refractory multiple myeloma (RRMM). DARA works by targeting the CD38 portion of malignant cells; however, this drug attaches to the red blood cell (RBC) reagents used in blood banks, further complicating the antibody identification work-up. The AABB (formerly known as the American Association of Blood Banks) has issued a memorandum on how blood banks can effectively address panreactivity caused by DARA...
October 28, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27794526/association-of-ucp2-866g-a-polymorphism-with-nonalcoholic-fatty-liver-disease-in-patients-from-north-west-of-iran
#2
Fatemeh Mohseni, Safar Farajnia, Mahdieh Abbasalizad Farhangi, Manouchehr Khoshbaten, Mohammad-Asghari Jafarabadi
OBJECTIVE: To investigate the association of uncoupling protein-2 (UCP2) -866G > A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). METHODS: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G > A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
October 28, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27771620/a-survey-of-knowledge-and-practices-of-transfusion-medicine-among-post-intern-doctors-in-specialized-hospital-in-sri-lanka
#3
Samantha Kumarage, Rahal Fernando, Lanka Gunasekara
BACKGROUND: Knowledge of transfusion medicine is the key element of better transfusion practices. This deficit observed at the blood bank end on daily basis exposing the patients for redundant risk. We assessed the knowledge of transfusion medicine among post intern doctors. OBJECTIVE: To assess the knowledge of transfusion medicine among post intern doctors in working in our hospital. METHODS: Self administrated questionnaire was used. 45 questions of transfusion medicine included in the questioner...
October 22, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27760802/cd127-expression-in-naive-and-memory-t-cells-in-hiv-patients-who-have-undergone-long-term-haart
#4
Wenfang Xu, Jie Li, Yong Wu, Jiankang Zhou, Jianping Zhong, Qiuqiong Lv, Hui Shao, Heping Rao
OBJECTIVE: To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression. METHODS: We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4(+)T < 350/µL, patients with general recovery (CD4(+)T =  350 - ∼600/µL) and patients with good recovery (CD4(+)T > 600/µL)...
October 19, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27744341/opportunities-to-enhance-laboratory-professionals-role-on-the-diagnostic-team
#5
Julie R Taylor, Pamela J Thompson, Jonathan R Genzen, John Hickner, Marisa B Marques
BACKGROUND: The 2015 Institue of Medicine report Improving Diagnosis in Health Care highlighted that diagnostic errors cause patient harm and that improvement in the diagnostic process requires better collaboration among physicians and laboratory professionals. The purpose of this study is to understand why physicians do not contact laboratory professionals when facing diagnostic challenges and identify opportunities for laboratory professionals to become more recognized members of the clinical care team...
October 15, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708176/about-the-journal
#6
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708175/table-of-contents-toc
#7
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708174/cover
#8
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708173/iqcp-guideline-and-helpful-tools-for-implementation
#9
Linda C Bruno
This article will help laboratories understand what changed with external quality control testing, why it changed, who changed it, when the changes became effective, and how these changes affect clinical laboratories. The new Individualized Quality Control Plan (IQCP) option that became effective January 1, 2016, will be explained. Three other quality control changes that took effect January 1, 2016, and dramatically affect quality control requirements for antimicrobial susceptibility testing, identification test systems, and exempt culture media will also be explained...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708172/handling-big-data-in-modern-healthcare
#10
Hassan A Aziz
The constant growth of medical knowledge and the increases in specialization in clinical practice have created a significant need to share and access patient information with speed and efficiency. However, current technology is centered on processing data, rather than gathering information. To realize the potential of modern technology in improving patient health, merely collecting and storing data are insufficient: one must convert these data into information and knowledge. In this article, I present an overview of 2 recent advances in technology and their assimilation into the practice of medicine, in the attempt to make clinical data meaningful and then to learn from aggregated clinical data...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708171/erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708170/prevalence-and-clinical-utility-of-incidental-critical-values-resulting-from-critical-care-laboratory-testing
#12
Caleb V Grieme, Dena R Voss, Karin E Olson, Scott R Davis, Jeff Kulhavy, Matthew D Krasowski
OBJECTIVE: Panels of clinical laboratory testing may generate "incidental" critical values from unordered parameters. Existing regulations do not clearly delineate guidelines for handling incidental critical values. The objective of this study was to examine the patterns and clinical utility of incidental critical values at 2 critical care laboratories within an academic medical center. METHODS: In this retrospective study, the electronic health record and laboratory information system were reviewed for incidental critical results obtained from blood gas analyzer analysis of whole blood specimens between November 2010 and August 2014...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708169/the-need-for-education-in-molecular-immunohematology-a-survey-of-specialists-in-blood-banking
#13
Stephanie N Kinney, Jayanna Slayten, Dan A Waxman
BACKGROUND: Within transfusion medicine, the education of molecular technologies lacks standardization. OBJECTIVE: To address this problem, we surveyed specialist in blood bank technology (SBBT) programs, immunohematology reference laboratories, and SBBT graduates to define its current state. METHODS: An anonymous online survey (SurveyMonkey) was emailed to the 15 American Association of Blood Banks (AABB) SBBT programs, 59 AABB IRLs, and 82 SBBT graduates...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27708168/dna-methylation-of-the-htert-gene-in-breast-cancer-revisited-diagnostic-and-clinical-implications
#14
Shahla Masood, Ehab El-Gabry, Chuhua Zhang, Zhiqiang Wang
BACKGROUND: It is documented that in tumor cell lines, the hTERT gene exhibits prominent methylation at a CpG island rich region about -600 bp upstream of the transcription start site, but mixed or allelically absent around ±150 bp region. Given the potential clinical implications of the findings in breast cancer diagnostics, we set out to investigate if such findings are reproducible on primary surgically resected invasive breast carcinomas. METHODS: The cohort consisted of 50 cases of freshly sampled and formalin-fixed paraffin embedded (FFPE) invasive breast cancers and normal tissue...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27614471/clonal-lymphoproliferations-in-a-patient-with-common-variable-immunodeficiency
#15
Sarah A Williams, Laura E Moench, Fatima Khan, Gregory Vercellotti, Michael A Linden
Common variable immunodeficiency (CVID) comprises a heterogeneous group of disorders of humoral immunity, characterized by marked deficiencies in serum immunoglobulins. Immune dysregulation causes susceptibility to recurrent bacterial infections, as well as autoimmune and lymphoproliferative disorders. Although the lymphoid cells comprising the atypical proliferations are often clonally related, their malignant potential and clinical significance differ from similar lesions in individuals with immunocompetence...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27593170/the-effectiveness-of-temperature-versus-aprotinin-in-maintaining-the-preanalytical-stability-of-adrenocorticotrophin
#16
Hakan Turkon, Burak Toprak, Hulya Yalcin, Ayfer Colak, Nurinnisa Ozturk
OBJECTIVE: To investigate the effect of temperature and protease inhibitor on adrenocorticotrophin (ACTH) stability. METHODS: We collected blood specimens from 10 donors into K3 EDTA (ethylenediaminetetraacetic acid) and K3 EDTA + aprotinin tubes. Plasma specimens were held at room temperature and at 2 °C to 8[Formula: see text] for 0, 2, 4, 8, 24, and 72 hours. ACTH concentrations in 4 storage conditions were compared with repeated-measures analysis of variance (ANOVA) at each time point...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27590349/association-of-dna-methyltransferase-3b-promotor-polymorphism-with-childhood-chronic-immune-thrombocytopenia
#17
Heba M Gouda, Nermine M Kamel, Safa S Meshaal
BACKGROUND: DNA methylation is an epigenetic process that refers to chromatin-based mechanisms in the regulation of gene expression without DNA alternation. It is mediated by DNA methyltransferases (DNMTs). The DNA methyltransferase 3B (DNMT3B) gene contains a C-to-T single nucleotide polymorphism (SNP; rs2424913) in the Promotor region, 149 base pairs from the transcription start site, which is reported to significantly increase the Promotor activity. OBJECTIVE: To investigate the prevalance of rs2424913 single nucleotide polymorphism located in the DNMT3B gene Promotor...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27572874/ethanol-values-during-college-football-season-university-policy-change-and-emergency-department-blood-ethanol-values-from-2006-through-2014
#18
Amelia C Fierro-Fine, Karisa Harland, Hans R House, Matthew D Krasowski
BACKGROUND: Tailgating is popular at many college football games. However, it is known to contribute to binge drinking and alcohol intoxication, which are common public health challenges. OBJECTIVE: To use laboratory data to measure changes in plasma ethanol levels observed in a large state university emergency department after a series of reforms were enacted to reduce binge drinking. METHODS: We performed a retrospective chart review on all serum ethanol levels measured at the University of Iowa Hospitals and Clinics on weekends from 2006 through 2014...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27558515/does-formaldehyde-increase-cell-free-dna-in-maternal-plasma-specimens
#19
Rintu R Jacob, Renu Saxena, Ishwar C Verma
BACKGROUND: There have been conflicting observations reported in the literature regarding the effects of formaldehyde in the recovery of cell free fetal DNA (CFF DNA) from maternal plasma. The aim of the present study was to assess the effect of formaldehyde treatment on circulating cell free DNA. METHODS: We conducted this study using blood specimens collected from 11 pregnant women, each of whom was carrying a male fetus. DYS14 and HBB real time assays were performed to quantify fetal and total circulating cell free DNA from formaldehyde treated and untreated maternal plasma specimens, respectively...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27538924/safe-reduction-of-blood-volume-in-the-blood-gas-laboratory
#20
Phillip R Jensen, Boaz A Markewitz
BACKGROUND: Phlebotomy is a significant cause of iatrogenic anemia in the critical care environment. It is estimated that one-third of all transfusions of packed red blood cells in intensive care units (ICU) result from phlebotomy. The aims of this study were to determine if utilizing the 1mL blood gas syringe for an adult population would impact the rate at which specimens were acceptable for testing and result reporting based on lab specimen rejection criteria; and to compare blood utilization between the 2 different syringes...
November 2016: Laboratory Medicine
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