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European Journal of Clinical Investigation

Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Georgios Georgiopoulos, Eleni Kokkou, Vasiliki Tsigkou, Marina Zaromitidou, Alexis Antonopoulos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G Papavassiliou, Dimitris Tousoulis
BACKGROUND: Arterial stiffness and vascular calcification significantly contribute to coronary atherosclerosis progression. The prognostic value of increased arterial stiffness and vascular calcification in subjects with stable coronary artery disease (CAD) after percutaneous coronary intervention(PCI) is currently under question. MATERIALS AND METHODS: We randomly enrolled 262 patients with stable CAD one month after successful PCI. Carotid femoral pulse wave velocity (PWV) was measured as a well-established index of central aortic stiffness...
January 13, 2018: European Journal of Clinical Investigation
Fabio Rigamonti, Federico Carbone, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Franco Dallegri, François Mach, Stefano Bertolini, Livia Pisciotta
Different cut-off values of serum lipoprotein(a) [Lp(a)] were recently identified in order to better stratify cardiovascular risk categories. Both pathophysiological and prognostic values of Lp(a) remain unclear. Here, the prognostic value of Lp(a) and its correlation with intraplaque features were assessed in patients with severe carotid artery stenosis undergoing endarterectomy (n=180). The cut-off value of 10 mg/dL for serum Lp(a) was selected to predict 24-month follow-up acute coronary syndrome (ACS). In addition, the association between serum Lp(a) and intraplaque lipids, collagen, inflammatory and vascular cells was assessed...
January 11, 2018: European Journal of Clinical Investigation
Penio Kassari, Panagiotis Papaioannou, Antonis Billiris, Haralampos Karanikas, Stergiani Eleftheriou, Eleftherios Thireos, Yannis Manios, George P Chrousos, Evangelia Charmandari
BACKGROUND: Obesity in childhood and adolescence represents a major health problem in our century. In Greece, more than 30-35% of children and adolescents are either overweight or obese. MATERIALS AND METHODS: Using information and communication technologies, we developed a "National Registry for the Prevention and Management of Overweight and Obesity in Childhood and Adolescence" for guidance and training of Pediatricians and General Practitioners. The application supports interoperability with other national infrastructures and multi-layered security spanning preventive, detective and administrative controls...
January 11, 2018: European Journal of Clinical Investigation
C C S Tseng, M M H Huibers, L H Gaykema, E Siera-de Koning, F Z Ramjankhan, A S Maisel, N de Jonge
BACKGROUND: The interleukin-33 (IL-33)/supressor of tumorigenicity 2 (ST2) pathway is suggested to play an important role in fibrosis, remodeling and the progression of heart failure (HF). Increased soluble (sST2) levels are associated with adverse outcome in the average HF population. Less is known about sST2 levels in end-stage HF. Therefore, we studied sST2 levels in end-stage HF and the effect of unloading by left ventricular assist device (LVAD) support on sST2 levels. METHOD AND RESULTS: Serial plasma measurements of sST2 were performed pre-implantation and 1, 3 and 6 months after (LVAD) implantation in 38 patients...
January 11, 2018: European Journal of Clinical Investigation
Cristina Montalbán-Méndez, Alberto Soriano-Maldonado, José Antonio Vargas-Hitos, Luis Manuel Sáez-Urán, Antonio Rosales-Castillo, Pablo Morillas-de-Laguno, Blanca Gavilán-Carrera, Juan Jiménez-Alonso
BACKGROUND: The aim of the present study was twofold: 1) to examine the association of cardiorespiratory fitness with arterial stiffness in women with systemic lupus erythematosus; 2) to assess the potential interaction of cardiorespiratory fitness with age on arterial stiffness in this population. MATERIALS AND METHODS: A total of 49 women with systemic lupus erythematosus (mean age 41.3 [Standard deviation 13.8] years) and clinical stability during the previous 6 months were included in the study...
January 10, 2018: European Journal of Clinical Investigation
Chun-Hung Su, Teng-Fu Tsao, An-Chih Chen, Kai-Wei Chang, Yi-Sun Yang, Kwo-Chang Ueng, Chin-Feng Tsai
BACKGROUND: The CHADS2 and CHA2 DS2 -VASc scores are clinical risk stratification instruments that are used clinically to assess the risk of stroke in patients with atrial fibrillation (AF). The aim of this study was to evaluate whether the pre-stroke CHADS2 and CHA2 DS2 -VASc scores could be useful for predicting infarction severity and long-term outcomes in patients of acute ischemic stroke. MATERIALS AND METHODS: This prospective study included all 1494 patients who had acute ischemic stroke without hemorrhagic transformation which were evidenced with magnetic resonance (MR) imaging during hospitalization...
December 29, 2017: European Journal of Clinical Investigation
Peter C Gøtzsche
In response to my paper, where I call for abolishment of patents and for drug research and development as a public enterprise, Raj asserts that there is an increase in novel drug discoveries. The fact is that even the drug industry laments that drug innovation has dried out, which is why they buy start-up companies. Big pharma doesn't invest in innovative research, as it is far more profitable to have creative marketing and legal departments than creative research divisions, and to develop an endless array of "me too" products...
December 27, 2017: European Journal of Clinical Investigation
Gerard Marshall Raj
First, I would like to congratulate the author for coming up with an innovative patent-less non-private model for the health care system. The author's statements are quite intriguing. However, I do have some queries and comments. The initial paragraph appears to be more cynical - as the novel drug molecules are not really 'new'. This point-of-view of the author could be more balanced and more non-regional (other than France). This article is protected by copyright. All rights reserved.
December 27, 2017: European Journal of Clinical Investigation
Mario Comassi, Eleonora Santini, Chiara Rossi, Edoardo Vitolo, Marta Seghieri, Leonardo Tocchini, Ferdinando Franzoni, Anna Solini
INTRODUCTION: The P2X7 receptor-NLRP3 inflammasome complex (P2X7R-Infl) regulates inflammatory and immune responses. Physical exercise modulates heath shock proteins (Hsps), influencing cytokine levels and oxidative stress; Hsp72 triggers P2X7R-Infl-dependent responses. Subjects and Methods We studied the effect of a single bout of maximal exercise on lymphomonocyte expression of P2X7R, NLRP3, caspase-1, NF-kB and Hsp72 and circulating levels of IL-1β, IL-18 and MCP-1, all modulated by P2X7R-Infl, in healthy sedentary (SED), trained (ATH), endurance (END) male individuals...
December 22, 2017: European Journal of Clinical Investigation
Fatemeh Khosravi Shadmani, Salman Khazaei, Shiva Mansouri Hanis, Kamyar Mansori
We studied the paper entitled 'Complement C3 and fatty liver disease in Rheumatoid arthritis patients: a cross-sectional study' written by Francesco URSINI et al.(1), which was published in European journal of clinical investigation in October 2017. The aim of the study was to evaluate the performance of C3 for prediction of NAFLD in RA patients. The results of this study in logistic regression model showed that only male sex (OR 2·65, 95% CI: 1·08-6·50, P = 0·03), increasing BMI (OR 1·22, 95% CI: 1·02-1·46, P = 0·03) and complement C3 (OR 5·05, 95% CI: 1·06-23·93, P = 0·04) were associated with higher likelihood of being diagnosed with NAFLD...
December 21, 2017: European Journal of Clinical Investigation
Francesco Ursini
We read with great interest the letter by Shadmani et al. regarding our recently published article investigating the correlation between complement C3 and non-alcoholic fatty liver disease (NAFLD) in rheumatoid arthritis (RA) patients [1]. The authors raised some technical issues about the statistical methodology of our work. This article is protected by copyright. All rights reserved.
December 21, 2017: European Journal of Clinical Investigation
Masaru Kato, Tatsuya Atsumi
Recent studies have clarified that pulmonary arterial hypertension associated with connective tissue diseases (CTD-PAH) has some distinctive clinical aspects from other PAH, such as high prevalence, venous and cardiac involvement, less favourable outcome, helpfulness of detection algorithm, response to immunosuppression, pre-PAH conditions in borderline pulmonary arterial pressure and coexistence of interstitial lung disease. In this review, by focusing on these distinctive aspects, we discuss how to provide an efficacious and safe management of CTD-PAH and garner attention to areas where further evidence is desired...
December 15, 2017: European Journal of Clinical Investigation
Peter C Gøtzsche
Our current system for researching, developing, approving, marketing and using drugs is financially and morally unsustainable. I propose an entirely new system where drug research and development will be a public enterprise, with no patents, and defined entirely by the public interest. Drug companies will have a limited role, selling services on a competitive basis to the publicly funded enterprise. This article is protected by copyright. All rights reserved.
December 15, 2017: European Journal of Clinical Investigation
A Picca, G Riezzo, A M S Lezza, C Clemente, V Pesce, A Orlando, G Chimienti, F Russo
BACKGROUND: Celiac disease (CD) is a gluten-sensitive autoimmune disorder. Gluten toxicity encompasses a wide spectrum of target organ functions and pathologies, including the activation of the immune response and triggering of oxidative stress. The aim of this study was to investigate inflammation and the redox balance in patients with active CD, and to evaluate whether alteration of mitochondrial function is involved in the disease status. DESIGN: In this prospective case-control study, blood samples from sixteen adult CD patients and sixteen healthy controls (HC) were investigated for IL-1β, IL-6, and IL-8 plasma concentrations, for serum PON1 arylesterase, total and MnSOD antioxidant enzymes activities, induced TBARs levels, and for lymphocyte mtDNA content...
December 15, 2017: European Journal of Clinical Investigation
Silvia Udali, Annalisa Castagna, Michela Corbella, Andrea Ruzzenente, Sara Moruzzi, Filippo Mazzi, Tommaso Campagnaro, Domenica De Santis, Antonia Franceschi, Patrizia Pattini, Rossella Gottardo, Oliviero Olivieri, Luigi Perbellini, Alfredo Guglielmi, Sang-Woon Choi, Domenico Girelli, Simonetta Friso
BACKGROUND: The liver hormone hepcidin regulates iron homeostasis that is often altered in hepatocellular carcinoma (HCC). Epigenetic phenomena control gene expression through a dynamic fashion, therefore, considering the plasticity of both iron homeostasis and epigenetic mechanisms and their role in liver carcinogenesis, we investigated whether hepcidin gene (HAMP) expression is modulated by DNA methylation thus affecting iron status in human HCC. MATERIALS AND METHODS: Thirty-two patients affected by non-viral HCC were enrolled and their main clinical and biochemical characteristics obtained...
December 13, 2017: European Journal of Clinical Investigation
Lars Lind, Erik Ingelsson, Johan Sundström, Agneta Siegbahn, Erik Lampa
BACKGROUND: DNA methylation changes over life at specific sites in the genome, which can be used to estimate "biological age". The aim of this population-based longitudinal cohort study was to investigate the association between estimated biological age and incident cardiovascular disease (CVD). MATERIALS AND METHODS: Based on formulas published by Hannum et al and Horvath et al, "biological age" was calculated using data from the Illumina 450k Bead Methylation chip in 832 participants free from cardiovascular disease in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (50% women, all aged 70 years at the examination)...
December 12, 2017: European Journal of Clinical Investigation
Benjamin Burggraaf, Deborah F van Breukelen-van der Stoep, Jendé van Zeben, Noelle van der Meulen, Gert-Jan M van de Geijn, Anho Liem, Pedro Valdivielso, José Rioja Villodres, José Ramírez-Bollero, Ellen van der Zwan, Manuel Castro Cabezas
BACKGROUND: Levels of apolipoprotein (apo) B48 may be increased in conditions associated with systemic inflammation and increased cardiovascular disease (CVD) risk like rheumatoid arthritis (RA). We aimed to evaluate apo B48 levels in patients with RA in relation to subclinical atherosclerosis. METHODS: Patients with RA (without CVD) and controls without RA but with high CVD risk (based on the presence of diabetes mellitus or a history of CVD) and healthy controls, were included in this cross-sectional study...
December 12, 2017: European Journal of Clinical Investigation
Oliver Soehnlein
Inflammation is a well-coordinated process in response to tissue injury or infection aimed at restoration of tissue homeostasis. Platelets and neutrophils are typically viewed important in the context of hemostasis and bacterial killing, respectively. However, as these cells are equipped with readily available armory both have received much attention for their importance in shaping the early inflammatory reaction in recent years. While some of these activities are executed individually, both cells join forces during much of their pro-inflammatory activities...
December 11, 2017: European Journal of Clinical Investigation
Jonas W Brinck, Aurélien Thomas, Marie-Claude Brulhart-Meynet, Estelle Lauer, Cecilia Frej, Björn Dahlbäck, Peter Stenvinkel, Richard W James, Miguel A Frias
BACKGROUND: Chronic kidney disease (CKD) exacerbates the risk of death due to cardiovascular disease (CVD). Modifications to blood lipid metabolism which manifest as increases in circulating triglycerides and reductions of high density lipoprotein (HDL)-cholesterol are thought to contribute to increased risk. In CKD patients, higher HDL-cholesterol levels were not associated with reduced mortality risk. Recent research has revealed numerous mechanisms by which HDL could favourably influence CVD risk...
November 27, 2017: European Journal of Clinical Investigation
Kamna Srivastava, Sudhir Chandra, Rajiv Narang, Jagriti Bhatia, Daman Saluja
BACKGROUND: Hypertension is associated with endothelial cell dysfunction. E-selectin, an endothelial cell adhesion molecule is specific for endothelial cell activation. Polymorphism in E-selectin gene has recently been identified among which Leu554Phe E-selectin gene polymorphism is least investigated in essential hypertension. Present study reports the association of E-selectin gene Leu554Phe polymorphism and the expression of E-selectin gene in patients with essential hypertension. MATERIALS AND METHODS: We analyzed the Leu554Phe polymorphism and expression of E-selectin gene in 250 patients with essential hypertension and 250 normal healthy controls...
November 25, 2017: European Journal of Clinical Investigation
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