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European Journal of Clinical Investigation

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https://www.readbyqxmd.com/read/28621798/the-relationship-of-serum-adipokines-with-malnutrition-inflammation-score-in-hemodialysis
#1
Elham Alipoor, Ahmad Esmaillzadeh, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges Sadat Zahed, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND: Protein-energy wasting is a prevalent disorder in hemodialysis. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with recognized lipolytic effects and proposed role in metabolic homeostasis. This study was conducted to investigate the association of ZAG and ATGL concentrations with malnutrition inflammation score (MIS) and metabolic profile of patients with hemodialysis. MATERIALS AND METHODS: Eighty-eight patients under regular hemodialysis divided based on MIS to normal to mild wasting (NMW; n=35) or moderate wasting (MW; n=53) groups...
June 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28555728/platelet-distribution-width-as-the-prognostic-marker-in-coronary-bifurcation-treatment
#2
Adam Kern, Robert J Gil, Krystian Bojko, Ewa Sienkiewicz, Beata Januszko-Giergielewicz, Jerzy Górny, Jacek Bil
INTRODUCTION: Mean platelet volume (MPV) was proved to be a reliable prognostic factor in cardiac patients. However, platelet distribution width (PDW) was disclosed to be more specific marker of platelet reactivity. The aim of study was to evaluate whether baseline PDW value can predict the outcome in patients undergoing percutaneous coronary interventions (PCI) with drug-eluting stent implantation within coronary bifurcation lesions. MATERIAL AND METHODS: It was a two-center observational study, which included patients who underwent PCI within bifurcation lesions between January 2014 and December 2014...
May 28, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28556177/outcome-predictor-in-dilated-cardiomyopathy-or-myocarditis
#3
Friedhelm Kuethe, Marcus Franz, Christian Jung, Christiane Porrmann, Franziska Reinbothe, Peter Schlattmann, Renate Egerer, Gerhard Mall
BACKGROUND: The objective of the present study was to identify parameters of prognostic relevance in patients presenting with chronic left ventricular dysfunction who underwent endomyocardial biopsy. METHODS: 351 consecutive patients (age 47.7±12.6 years, 281 male) with a chronic left ventricular dysfunction were enrolled. Endomyocardial biopsies were analysed by histopathology according to Dallas criteria and immunohistological WHO criteria. Virus genome was detected by polymerase chain reaction...
May 27, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28556061/acetylsalicylic-acid-in-critically-ill-patients-a-cross-sectional-and-a-randomized-trial
#4
Christian Schoergenhofer, Eva-Luise Hobl, Michael Schwameis, Georg Gelbenegger, Thomas Staudinger, Gottfried Heinz, Walter S Speidl, Christian Zauner, Birgit Reiter, Irene Lang, Bernd Jilma
BACKGROUND: Despite decades of clinical use, the pharmacokinetics and the effects of acetylsalicylic acid (ASA) in critically ill patients remain ill-defined. We aimed to investigate the pharmacokinetics and the effects of different ASA formulations during critical illness. DESIGN: A cross-sectional study and a randomized, parallel-group trial were performed. Critically ill patients under chronic oral ASA treatment (100mg enteric-coated) were screened for high "on treatment" platelet reactivity (HTPR) according to arachidonic acid-induced whole blood aggregometry...
May 27, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28542805/downregulation-of-cholesteryl-ester-transfer-protein-by-glucocorticoids-a-randomized-study-on-hdl
#5
Jorien Werumeus Buning, Lidya G Dimova, Frank G Perton, Uwe J F Tietge, André P van Beek, Robin P F Dullaart
BACKGROUND: High density lipoprotein (HDL) cholesterol is not decreased in hypercortisolism despite high triglycerides, which may be ascribed to effects on the cholesteryl ester transfer protein (CETP) pathway. We explored if CETP mRNA expression is modulated by glucocorticoid treatment in vitro. Effects of doubling the hydrocortisone (HCT) replacement dose on plasma CETP activity and HDL characteristics were tested in patients with secondary adrenal insufficiency. MATERIALS AND METHODS: Human THP-1 macrophages were incubated with corticosterone in vitro in the presence or absence of a liver X receptor (LXR) agonist, followed by determination of CETP mRNA levels by quantitative real-time PCR...
May 24, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28517037/serum-phosphate-is-related-to-adiposity-in-healthy-adults
#6
Emma O Billington, Greg D Gamble, Sarah Bristow, Ian R Reid
BACKGROUND: Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations. METHODS: Cross-sectional data from three independent cohorts, consisting of healthy adult males (Male Cohort, n=323) and healthy postmenopausal women (Female Cohort 1, n=185; and Female Cohort 2, n=1471), are reported...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28517024/treatment-of-severe-alcoholic-hepatitis-past-present-and-future
#7
REVIEW
Nicolas Lanthier, Peter Stärkel
Alcoholic hepatitis manifests as a clinical syndrome characterized by recent jaundice and liver function deterioration in an actively drinking patient. The principal cause of alcoholic hepatitis is alcoholic steatohepatitis defined histologically by the coexistence of steatosis, hepatocyte ballooning and satellitosis. While non-severe alcoholic hepatitis usually responds to alcohol abstinence, severe alcoholic hepatitis, identified by Maddrey scoring ≥ 32, has a bad prognosis and is traditionally treated by a 28-day course of prednisone therapy...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28517022/impact-and-management-of-left-ventricular-function-on-the-prognosis-of-takotsubo-syndrome
#8
Ibrahim El-Battrawy, Uzair Ansari, Siegfried Lang, Michael Behnes, Katja Schramm, Christian Fastner, Xiaobo Zhou, Jürgen Kuschyk, Erol Tülümen, Susanne Röger, Martin Borggrefe, Ibrahim Akin
AIMS: Early research has proposed that patients with Takotsubo syndrome (TTS) could have a higher mortality rate than the general population. Our study was conducted to determine the short- and long-term outcome of TTS patients associated with a significantly compromised left ventricular function on hospital admission. METHODS AND RESULTS: Our institutional database constituted a collective of 112 patients diagnosed with TTS between 2003 and 2015. The patients were classified into two groups based on the left ventricular ejection fraction (LVEF), with those presenting with a LVEF >35% on admission categorized into one group (n=65, 58%) and those presenting with LVEF ≤35% (n=47, 42%) categorized into another group...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28425090/determinants-of-the-postpericardiotomy-syndrome-a-systematic-review
#9
REVIEW
Dirk van Osch, Hendrik M Nathoe, Kirolos A Jacob, Pieter A Doevendans, Diederik van Dijk, Willem J Suyker, Jan M Dieleman
BACKGROUND: Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of PPS in adult cardiac surgery patients. MATERIAL AND METHODS: Two independent investigators performed a systematic search in MEDLINE, EMBASE and the Cochrane Central Register...
April 20, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28415155/letter-to-the-editor-regarding-dounousi-e-et%C3%A2-al-intact-fgf23-and-%C3%AE-klotho-during-acute-inflammation-sepsis-in-ckd-patients-eur-j-clin-invest-2016-46-234-41
#10
Axel Schlitt, Urban Sester, Martina Sester, Sarah Seiler-Mussler, Vincent Brandenburg, Elke Schäffner, Gunnar H Heine
With interest we read the recent European Journal of Clinical Investigation paper entitled "Intact FGF23 and α-Klotho during acute inflammation/sepsis in CKD patients" by E. Dounousi and coworkers (1). In their article, the authors analyse the association between acute infection and plasma levels of the phosphaturic hormone fibroblast growth factor 23 (FGF-23). The physiological regulation of FGF-23 is not fully understood so far, and hence novel pathophysiological data are of importance. Particularly the link between FGF23 and inflammation is a growing field...
April 17, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28407234/mediterranean-diet-decreases-adolescent-waist-circumference
#11
Flora Bacopoulou, Georgios Landis, Anastasios Rentoumis, Artemis Tsitsika, Vasiliki Efthymiou
BACKGROUND: To explore the effects of a multicomponent-multilevel school-based educational intervention on the nutritional habits and abdominal obesity indices of a representative adolescent sample. MATERIALS AND METHODS: A representative sample of 1610 adolescents aged 12-17 years in 23 public high schools of three municipalities in the Attica region in Greece participated in a programme funded by the European Union (August 2013-August 2014). Participants underwent dietary assessment with the use of the Mediterranean Diet Quality Index in children and adolescents (KIDMED), blood pressure (BP) assessment and screening for general and abdominal obesity by measuring body mass index, waist circumference (WC) and waist-to-height ratio (WHtR), at baseline and following a 6-month school-based intervention...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28407232/observed-survival-benefit-of-mild-therapeutic-hypothermia-reanalysing-the-circulation-improving-resuscitation-care-trial
#12
Alexander Nürnberger, Harald Herkner, Fritz Sterz, Jan-Aage Olsen, Michael Lozano, Pierre M van Grunsven, E Brooke Lerner, David Persse, Reinhard Malzer, Marc A Brouwer, Mark Westfall, Chris M Souders, David T Travis, Ulrich R Herken, Lars Wik
BACKGROUND: Mild therapeutic hypothermia is argued being beneficial for outcome after cardiac arrest. MATERIALS AND METHODS: Retrospective analysis of Circulation Improving Resuscitation Care (CIRC) trial data to assess if therapeutic cooling to 33 ± 1 °C core temperature had an association with survival. Of 4231 adult, out-of-hospital cardiac arrests of presumed cardiac origin initially enrolled, eligibility criteria for therapeutic hypothermia were met by 1812...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28407216/real-world-stroke-prevention-strategies-in-nonvalvular-atrial-fibrillation-in-patients-with-renal-impairment
#13
Kadir U Mert, Gurbet Ö Mert, Özcan Başaran, Osman Beton, Volkan Dogan, Mehmet Tekinalp, Ahmet Ç Aykan, Ezgi Kalaycıoğlu, Ismail Bolat, Onur Taşar, Özgen Şafak, Macit Kalçık, Mehmet Yaman, Cevat Kırma, Murat Biteker
BACKGROUND: The data regarding stroke prevention strategies in nonvalvular atrial fibrillation (NVAF) are limited especially in patients with renal impairment (RI). We sought to evaluate management dilemmas in patients with concurrent NVAF and RI in RAMSES (ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies inTurkey) study. METHODS: We conducted a prospective, multicenter, nation-wide registry in NVAF patients in outpatient cardiology clinics. All consecutive patients with NVAF were enrolled in RAMSES study (ClinicalTrials...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28382625/smoking-and-obesity-in-systemic-lupus-erythematosus-a-cross-sectional-study
#14
Mathilde Versini, Shmuel Tiosano, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Howard Amital
BACKGROUND: Both smoking and obesity have been demonstrated as risk factors in several autoimmune diseases. Little is known about the relationship between systemic lupus erythematosus (SLE) and both smoking and obesity. OBJECTIVES: To investigate the association between SLE, tobacco consumption and body mass index (BMI). MATERIALS AND METHODS: Using data from the largest Health Maintenance Organization (HMO) in Israel, the Clalit Health Services, we searched for an association between SLE, smoking and obesity...
April 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28380255/comparative-effects-of-the-restriction-method-in-two-large-observational-studies-of-body-mass-index-and-mortality-among-adults
#15
Katherine M Flegal, Barry I Graubard, Sang-Wook Yi
BACKGROUND: A method applied in some large studies of weight and mortality is to begin with a well-defined analytic cohort and use successive restrictions to control for methodologic bias and arrive at final analytic results. MATERIALS AND METHODS: Two observational studies of body mass index and mortality allow a comparative assessment of these restrictions in very large data sets. One was a meta-analysis of individual participant data with a sample size of 8 million...
April 5, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369870/antihyperglycemic-drugs-use-and-new-onset-atrial-fibrillation-in-elderly-patients
#16
Hung-Yi Chen, Fu-Yu Yang, Gwo-Ping Jong, Yi-Sheng Liou
BACKGROUND: Antihyperglycemic drugs have been linked to new-onset atrial fibrillation (NAF). However, the effect of the different classes of antihyperglycemic drugs on the development of NAF in elderly patients has not been well studied. In this study, we investigated the association between different classes of antihyperglycemic drugs and NAF in elderly patients. MATERIALS AND METHODS: This was a nested case-control study performed using the database of National Health Insurance programme in Taiwan...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369858/challenges-in-gluten-free-diet-in-coeliac-disease-prague-consensus
#17
REVIEW
Gabriel Samasca, Aaron Lerner, Anamaria Girbovan, Genel Sur, Iulia Lupan, Peter Makovicky, Torsten Matthias, Hugh J Freeman
BACKGROUND: New treatments in coeliac disease are being vigorously pursued to either replace or facilitate the difficult-tofollow gluten-free diet. DESIGN: The present review intends to summarise the challenges in gluten-free diet adherence during the transitional period, as reflected in the last Prague consensus, published in 2016. RESULTS: The honourable panel members recommended that dietary adherence and the consequences of nonadherence represent key components for discussion in the transitional period setting...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369799/effect-of-dental-pulp-stem-cells-in-mptp-induced-old-aged-mice-model
#18
Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Christopher Simon, Quan Fu Gan, Vui King Vincent-Chong, Vasudevan Mani, Kesavanarayanan Krishnan Selvarajan, Vellayan Subramaniam, Sabri Musa, Noor Hayaty Abu Kasim
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic (DA-ergic) neurons in the substantia nigra (SN) and represented as a huge threat to the geriatric population. Cell replacement therapies (CRTs) have been proposed as a promising strategy to slow down or replace neuronal loss. Among the widely available cell sources, dental pulp stem cells (DPSCs) portray as an attractive source primarily due to their neural crest origin, ease of tissue procurement and less ethical hurdles...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369867/alkaline-phosphatase-and-prognosis-in-patients-with-coronary-artery-disease
#19
Gjin Ndrepepa, Erion Xhepa, Siegmund Braun, Salvatore Cassese, Massimiliano Fusaro, Heribert Schunkert, Adnan Kastrati
BACKGROUND: The evidence on the association between alkaline phosphatase (ALP) and prognosis of patients with coronary artery disease (CAD) is limited. The aim of this study was to assess the association of ALP with the risk of mortality or coronary events in patients with CAD. MATERIALS AND METHODS: The study included 5540 patients with angiography-proven CAD treated with catheter-based coronary revascularization. Baseline ALP measurements were available for analysis in all patients...
March 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28489248/intact-fgf23-and-%C3%AE-klotho-during-acute-inflammation-sepsis-in-ckd-patients
#20
LETTER
Evangelia Dounousi, Claudia Torino, Patrizia Pizzini, Sebastiano Cutrupi, Vincenzo Panuccio, Graziella D'Arrigo, Samar Abd ElHafeez, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
No abstract text is available yet for this article.
June 2017: European Journal of Clinical Investigation
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