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European Journal of Clinical Investigation

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https://www.readbyqxmd.com/read/28906545/adipose-tissue-content-of-saturated-fatty-acids-and-atrial-fibrillation-a-case-cohort-study
#1
Pia Thisted Dinesen, Thomas Andersen Rix, Albert Marni Joensen, Anne Tjønneland, Søren Lundbye-Christensen, Kim Overvad, Erik Berg Schmidt
OBJECTIVES: The aim of the present study was to investigate the association between adipose tissue content of total saturated fatty acids including myristic (C14:0), palmitic (C16:0) and stearic (C18:0) acid, as a measure of exposure to saturated fatty acids and the risk of incident atrial fibrillation. MATERIALS AND METHODS: A total of 57,053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline and this was analysed for saturated fatty acids content by gas chromatography...
September 14, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28881005/relationship-between-family-history-of-type-2-diabetes-and-serum-fgf21
#2
Greggory R Davis, Tiffany Deville, Joshua Guillory, David Bellar, Arnold G Nelson
BACKGROUND: Determining predictive markers for the development of type 2 diabetes (T2D), particularly in young individuals, offers immense potential benefits in preventative medicine. Previous research examining serum fibroblast growth factor 21 (FGF21) in humans has revealed equivocal relationships with clinical markers of metabolic dysfunction. However, it is unknown to what extent, if any, first degree family history of T2D (mother or father of the participant diagnosed with T2D) level affects serum FGF21 levels...
September 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28881000/how-to-survive-the-medical-misinformation-mess
#3
John P A Ioannidis, Michael E Stuart, Shannon Brownlee, Sheri A Strite
Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, missed opportunities for right care and wasted healthcare resources. The Medical Misinformation Mess comprises four key problems. First, much published medical research is not reliable or is of uncertain reliability, offers no benefit to patients, or is not useful to decision makers. Second, most healthcare professionals are not aware of this problem...
September 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28861912/diagnosis-checking-of-statistical-analysis-in-rcts-indexed-in-pubmed
#4
Paul H Lee, Andy C Y Tse
BACKGROUND: Statistical analysis is essential for reporting of the results of randomized controlled trials (RCTs), as well as evaluating their effectiveness. However, the validity of a statistical analysis also depends on whether the assumptions of that analysis are valid. OBJECTIVE: To review all RCTs published in journals indexed in PubMed during December 2014 to provide a complete picture of how RCTs handle assumptions of statistical analysis. METHODS: We reviewed all RCTs published in December 2014 that appeared in journals indexed in PubMed using the Cochrane highly sensitive search strategy...
September 1, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28815569/glucose-dependent-leukocyte-activation-in-familial-hypercholesterolemia
#5
Natasja Koks, Marijke A de Vries, Erwin Birnie, Arash Alipour, Manuel Castro Cabezas
BACKGROUND: Leukocyte activation is an obligatory factor in the development of atherosclerosis. The postprandial situation has been associated to increased leukocyte activation in several disorders, such as type 2 diabetes mellitus and familial combined hyperlipidemia. Our study aim was to evaluate the effect of post-OGTT hyperglycemia on leukocyte activation in patients with familial hypercholesterolemia (FH). MATERIALS AND METHODS: Patients who met the diagnostic criteria for heterozygous FH and healthy volunteers were asked to undergo an oral glucose tolerance test...
August 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28815568/gliptin-therapy-reduces-hepatic-and-myocardial-fat-in-type-2-diabetic-patients-gliptins-and-cardiometabolic-risk
#6
Lana Kosi-Trebotic, Jürgen Harreiter, Marek Chmelik, Anita Thomas, Ivica Just-Kukurova, Siegfried Trattnig, Alexandra Kautzky-Willer
AIMS: Increased hepatic and cardiac fat are common in patients with Type 2 diabetes mellitus (T2DM) and associated with greater risk of liver fibrosis and cardiovascular (CV) events. Sex-specific differences of Dipeptidyl peptidase-four (DPP-4) inhibitor effects on hepatic (HCL) and myocardial fat content (MYCL) have not been evaluated yet. METHODS: 41 T2DM patients received a gliptin add-on therapy when not reaching HbA1c goals under metformin monotherapy. They underwent cardiac and liver magnetic resonance tomography and spectroscopy before and 6 months after therapy initiation...
August 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28804899/coronary-artery-disease-and-risk-of-adverse-cardiac-events-and-stroke
#7
Kevin Kris Warnakula Olesen, Morten Madsen, Gregory Lip, Gro Egholm, Troels Thim, Lisette Okkels Jensen, Bent Raungaard, Jens Cosedis Nielsen, Hans Erik, Henrik Toft Sørensen, Michael Maeng
BACKGROUND: Patients with acute myocardial infarction are at increased risk of ischemic stroke. Previous myocardial infarction is an important part of risk assessment for ischemic stroke. However, there is a lack of information regarding the association between the severity and extent of coronary artery disease and long-term risk of ischemic stroke. MATERIALS AND METHODS: A cohort study of coronary angiographies performed in Western Denmark from January 1, 2003 to December 31, 2012...
August 14, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796366/adrenomedullin-and-galanin-responses-to-orthostasis-in-older-persons
#8
James Broadbent, Johannes Reichmuth, Irhad Trozic, Markus Kneihsl, Andreas Rössler, David A Green, Joel Rodriguez, Helmut Hinghofer-Szalkay, Franz Fazekas, Nandu Goswami
BACKGROUND: Neuroendocrine responses to orthostasis may be critical in the maintenance of mean arterial pressure in healthy individuals. A greater reduction in orthostatic tolerance with age may relate to modulation of hormonal responses such as adrenomedullin and galanin. Thus, we investigated 1) whether adrenomedullin and galanin concentrations increase during orthostatic challenge in older subjects, 2) whether adrenomedullin and galanin concentrations are higher in older females compared with older males when seated and during orthostatic challenge, and 3) whether postural changes in plasma concentrations of galanin are correlated with levels of adrenomedullin in either older females or males...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796316/effects-of-tocilizumab-on-neutrophil-function-and-kinetics
#9
Laurence S C Lok, Neda Farahi, Jatinder K Juss, Chrystalla Loutsios, Chandra K Solanki, A Michael Peters, Francis Donaldson, Benjamin Porter-Brown, Edwin R Chilvers
BACKGROUND: Decreases in circulating neutrophils (polymorphonuclear leukocytes, PMNs) have been reported in patients treated with the anti-interleukin-6 receptor (IL-6R) antibody tocilizumab (TCZ); the mechanism for this is unclear. We hypothesize that TCZ reduces circulating neutrophils by affecting margination and / or bone marrow trafficking without affecting neutrophil function or apoptosis. MATERIALS AND METHODS: 18 healthy subjects were randomized to single intravenous dose of TCZ 8 mg/kg (n = 12) or placebo (n = 6) on day 0...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796313/lean-body-mass-and-creatine-kinase-is-associated-with-reduced-inflammation-in-obesity
#10
Svein I Bekkelund, Rolf Jorde
OBJECTIVE: Obesity is associated with inflammation, but the role of lean mass and creatine kinase (CK) on the inflammatory process is less known. We investigated the associations between lean mass, CK and fat mass upon inflammatory parameters in an overweight and obese adult population. METHODS: Body composition measured with dual-energy X-ray absorptiometry, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), CK and supplementary clinical parameters were measured in 454 overweight and obese individuals...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796299/complement-c3-and-fatty-liver-disease-in-rheumatoid-arthritis-patients-a-cross-sectional-study
#11
Francesco Ursini, Emilio Russo, Daniele Mauro, Ludovico Abenavoli, Giorgio Ammerata, Alfonso Serrao, Rosa Daniela Grembiale, Giovambattista De Sarro, Ignazio Olivieri, Salvatore D'Angelo
BACKGROUND: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of non-alcoholic fatty liver disease (NAFLD) in the general population. Aim of the present study was to evaluate the performance of C3 for prediction of NAFLD in RA patients. MATERIALS AND METHODS: For the present study, consecutive RA patients were recruited. NAFLD was diagnosed according to predefined ultrasonographic (US) criteria. For comparison, the hepatic steatosis index (HSI) was calculated...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796293/il7ra-polymorphisms-are-not-associated-with-aids-progression
#12
Luz María Medrano, José Luis Jiménez, María A Jiménez-Sousa, Amanda Fernández-Rodíguez, Mónica Gutiérrez-Rivas, José María Bellón, José Ramón Blanco, Alexy Inciarte, Mª Ángeles Muñoz-Fernández, Salvador Resino
BACKGROUND: Our aim was to determine whether α-chain of the IL-7 Receptor (IL7RA) polymorphisms (rs10491434, rs6897932, and rs987106) are associated with the clinical pattern of AIDS progression in ART-naïve HIV-infected patients. METHODS: We carried out a cross-sectional study in 673 HIV-infected patients who were classified into three groups according to the clinical pattern of AIDS progression (188 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 151 rapid progressors (RPs))...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796281/changes-in-protein-serum-levels-during-stem-cell-transplantation
#13
Elisabetta Metafuni, Sabrina Giammarco, Daniela Giovanna De Ritis, Monica Rossi, Francesco Corrente, Nicola Piccirillo, Andrea Paolo Bacigalupo, Simona Sica, Patrizia Chiusolo
BACKGROUND: GvHD is one of the major complication after stem cell transplantation affecting transplant-related mortality. Throughout the last years, many serum proteins were been proposed as possible biomarkers for GvHD. AIMS: We studied the trend of five of the most studied serum proteins to evaluate if a correlation exists between proteins concentration and post-HSCT outcomes. MATERIALS AND METHODS: We measured serum concentration of REG3α, ST2, BAFF, CXCL9 and elafin in a cohort of 77 patients submitted to HSCT in our department...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796277/talking-the-talk-but-not-walking-the-walk-rt-qpcr-as-a-paradigm-for-the-lack-of-reproducibility-in-molecular-research
#14
REVIEW
Stephen Bustin, Tania Nolan
Poorly executed and inadequately reported molecular measurement methods are amongst the causes underlying the lack of reproducibility of much biomedical research. Although several high impact factor journals have acknowledged their past failure to scrutinise adequately the technical soundness of manuscripts, there is a perplexing reluctance to implement basic corrective measures. The reverse transcription real time quantitative PCR (RT-qPCR) is probably the most straightforward measurement technique available for RNA quantification and is widely used in research, diagnostic, forensic and biotechnology applications...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28795765/vitamin-d-predictors-in-polycystic-ovary-syndrome-a-meta-analysis
#15
Flora Bacopoulou, Evangelia Kolias, Vasiliki Efthymiou, Constantine N Antonopoulos, Evangelia Charmandari
BACKGROUND: The aim of this meta-analysis was to examine differences and predictors of serum 25-hydroxyvitamin D concentrations in women with polycystic ovary syndrome (PCOS) compared with non-PCOS controls matched for body mass index. MATERIALS AND METHODS: Three databases were searched (2003-2015) to retrieve studies that evaluated serum 25-hydroxyvitamin D in PCOS women and controls. Meta-regression analysis was performed with anthropometric and metabolic/endocrine parameters as covariates...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28783210/monocyte-count-at-onset-predicts-post-stroke-outcomes-during-a-90-day-follow-up
#16
Luca Liberale, Fabrizio Montecucco, Aldo Bonaventura, Ilaria Casetta, Silva Seraceni, Alessandro Trentini, Marina Padroni, Franco Dallegri, Enrico Fainardi, Federico Carbone
BACKGROUND: Acute ischemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing post-stroke recovery. In smokers with AIS inflammation might be further upregulated, increasing ischemia/reperfusion injury. Here, the predictive value of leukocyte and adhesion molecules levels on post-stroke outcomes was investigated. MATERIALS AND METHODS: 89 patients with AIS (n=30 smokers and n=59 non-smokers) were recruited and evaluated 1, 7 and 90 days after the onset to assess stroke severity by the National Institute of Health Stroke Scale (NIHSS) score as well as clinical recovery at 90 day by the modified Rankin Scale (mRS)...
August 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28783209/impact-of-pre-operative-cardiology-consultation-prior-to-intermediate-risk-surgical-procedures
#17
Volkan Dogan, Murat Biteker, Eda Özlek, Bülent Özlek, Özcan Başaran, Birdal Yıldırım, Kadir Kayataş, Oğuzhan Çelik, Marwa Mouline Doğan
BACKGROUND: Patients undergoing noncardiac, nonvascular surgery (NCNVS) are at risk of perioperative cardiovascular events. However, benefits of cardiology consultation (CC) in patients with known or suspected cardiac disease undergoing intermediate-risk NCNVS is unknown. METHODS: The study group included 700 consecutive patients referred for CC before intermediate-risk NCNVS in a tertiary-care teaching hospital. The control group included 1200 age-matched and sex-matched consecutive patients proceeded to the intermediate-risk surgery without preoperative CC during the same period...
August 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28771706/predictive-factors-for-successful-renal-denervation-should-we-use-them-in-clinical-trials
#18
REVIEW
Nicolas Barber-Chamoux, Murray D Esler
Renal denervation is facing various challenges to its initial claimed value in hypertension treatment. Major concerns are the choice of the patients and the technical efficacy of the renal denervation. Different factors have been described as predicting the capacity of renal denervation to decrease blood pressure. These factors are related to the patients, the procedure and the tools to confirm successful neural ablation. Their use in future trials should help to improve renal denervation trials understanding and outcomes...
August 3, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28771692/predialysis-chronic-kidney-disease-correlates-with-increased-risk-of-pyogenic-liver-abscess-a-population-based-cohort-study
#19
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
BACKGROUND/OBJECTIVE: The incidence of pyogenic liver abscess in Taiwan appears to be much higher than that in western countries. However, little is known about the incidence of pyogenic liver abscess among patients with predialysis chronic kidney disease. The objective of this study was to assess the association between predialysis chronic kidney disease and the risk of pyogenic liver abscess in Taiwan. METHODS: This population-based, retrospective, cohort study was conducted to analyze the database of the Taiwan National Health Insurance Program...
August 3, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28746976/glucose-targeted-therapy-for-subjects-with-type-2-diabetes-mellitus-primum-non-nocere
#20
EDITORIAL
Davide Maggi, Caterina Bordone, Lucia Briatore, Valeria Cheli, Luigi Fontana, Chiara Mazzucchelli, Fabrizio Montecucco, Gianfranco Adami, Renzo Cordera
Type 2 Diabetes (T2DM) is a complex disease that is not limited to hyperglycemia. Anti-diabetic treatments aimed at preventing late onset complications and avoiding both hypo- and hyperglycemic events. Unfortunately, recently discovered anti-diabetic drugs only modestly impacted on disease clinical outcome. This article is protected by copyright. All rights reserved.
July 26, 2017: European Journal of Clinical Investigation
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