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European Journal of Clinical Investigation

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https://www.readbyqxmd.com/read/28722189/adam10-modulates-calcitriol-regulated-rage-in-cardiomyocytes
#1
Ting-Wei Lee, Yu-Hsun Kao, Ting-I Lee, Yi-Jen Chen
BACKGROUND: Receptor for advanced glycation end products (RAGE) signaling plays a critical role in the pathogenesis of cardiovascular disease. Calcitriol modulates cardiac RAGE expression. This study explored the mechanisms underlying the effect of calcitriol on RAGE and soluble RAGE (sRAGE) expression in cardiomyocytes. METHODS: Western blot, ELISA, fluorometric assay and PCR analyses were used to evaluate the RAGE, sRAGE, endogenous secretory RAGE (esRAGE), Jun N-terminal kinase (JNK), and a disintegrin and metalloprotease 10 (ADAM10) expression and enzyme activity in HL-1 atrial myocytes without and with calcitriol (10 and 100 nM), nuclear factor-κB (NF-κB) inhibitor (50 μg/mL), or ADAM10 inhibitor (5 μM) incubation for 48 hours...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28722106/anti-inflammatory-effects-of-exercise-role-in-diabetes-and-cardiovascular-disease
#2
REVIEW
Bente Klarlund Pedersen
BACKGROUND: Persistent inflammation is involved in the pathogenesis of chronic diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). AIMS: The aim of this review was to provide the reader with an update of the mechanisms whereby exercise-induced cytokines may impact cardiometabolic diseases. RESULTS: Evidence exists that interleukin (IL)-1β is involved in pancreatic β-cell damage, whereas TNF-α is a key molecule in peripheral insulin resistance...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28722105/hepatic-cxcl16-is-increased-in-gallstone-accompanied-with-liver-injury
#3
Saisai Zhang, Wei Zhang, Lihua Shi, Anqi Xie, Yihui Shao, Yanna Ye, Xuebo Pan, Zhuofeng Lin, Xiaokun Li, Yi Zhang
BACKGROUND AND AIMS: The current study aimed to investigate the relationship between circulating Soluble C-X-C chemokine ligand 16 (CXCL16) levels and clinical characteristics of gallstone. METHODS: 93 subjects including 53 subjects with gallstone, 25 subjects with non-alcoholic fatty liver disease (NAFLD) and 40 control subjects were recruited. All gallstone subjects underwent ultrasounds to confirm the gallstone patients. Serum CXCL16 levels and other clinical and biochemical parameters in all subjects were obtained based on standard clinical examination methods...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28707728/association-of-adenylate-cyclase-associated-protein-1-with-coronary-artery-disease
#4
J Munjas, M Sopić, V Spasojević-Kalimanovksa, D Kalimanovska-Oštrić, K Anđelković, Z Jelić-Ivanović
INTRODUCTION: Adenylate cyclase-associated protein 1 (CAP1) is a recently identified receptor for human resistin. Since resistin has been related to CAD development and progression and CAP1 has never been evaluated in CAD, the aim of this study was to determine its peripheral blood mononuclear cells (PBMCs) mRNA in CAD patients, and resistin plasma concentration, PBMCs resistin and CD36 mRNA,considering resistin's ability to stimulate CD36 expression in vitro METHODS: This case-controlled study included 27 healthy subjects (CG) and 66 patients requiring coronary angiography...
July 14, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28683166/multi-biomarker-analysis-in-patients-with-acute-myocardial-infarction
#5
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, P Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analyzed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n=61; NSTEMI, n=57) compared to controls with excluded coronary artery disease (n=76)...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28683162/an-observational-study-of-microcirculation-in-dialysis-patients-and-kidney-transplant-recipients
#6
Yu Chang Yeh, Anne Chao, Chih-Yaun Lee, Chen-Tse Lee, Chi-Chuan Yeh, Chih-Min Liu, Meng-Kun Tsai
BACKGROUND: Microcirculatory dysfunction contributes to acute and chronic kidney diseases. To the best of our knowledge, no study has compared differences in microcirculation among healthy volunteers, dialysis patients, and kidney transplant recipients. MATERIALS AND METHODS: Sublingual microcirculation was examined using sidestream dark field imaging and was compared among 90 healthy volunteers, 40 dialysis patients, and 40 kidney transplant recipients. The gender effect on microcirculation and the correlations among the microcirculation parameters, age, body mass index, heart rate, and blood pressure were analyzed...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28682461/influence-of-decision-aids-on-oral-anticoagulant-prescribing-among-physicians-a-randomized-trial
#7
Cristian Baicus, Caterina Delcea, Alina Dima, Emilia Oprisan, Ciprian Jurcut, Gheorghe Andrei Dan
BACKGROUND: Oral anticoagulants (OAC) are underused in treatment of atrial fibrillation (AF), with differences in patient and physician preferences. For risk communication, the graphic showing risks on treatment contains all the information, therefore the graphic showing risks without treatment may not be necessary. Here, our objective was to assess whether decision aids require information of risks without treatment and specifically whether presentation of 5-year stroke risk in patients with AF increases use of OACs compared with presentation of 1-year risk and whether decisions on treatment are different when physicians decide their own treatment versus that of the patient...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28678379/a-novel-cluster-of-patients-with-familial-mediterranean-fever-in-southern-italy
#8
Leonilde Bonfrate, Giuseppe Scaccianoce, Giuseppe Palasciano, Eldad Ben-Chetrit, Piero Portincasa
BACKGROUND: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder characterized by recurrent attacks of fever and serositis (peritonitis, pleuritic or synovitis) affecting mainly populations of Mediterranean origin. AIM: To describe a relatively new cluster of FMF subjects from Apulia and Basilicata regions (southern Italy). PATIENTS AND METHODS: Subjects were screened for FMF using the Tel-Hashomer criteria and genetic analysis...
July 5, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28675422/reviving-cochrane-s-contribution-to-evidence-based-medicine-bridging-the-gap-between-evidence-of-efficacy-and-evidence-of-effectiveness-and-cost-effectiveness
#9
Jack E James
Evidence-based medicine (EBM) has been widely adopted as the main means for transforming medical practice informed by individual practitioner experience to that informed by science. Yet, as a movement for comprehensive change, EBM has not been as transformative as had been widely anticipated. Evidence of clinical efficacy is often organized hierarchically with the randomized controlled trial located towards the apex of an imaginary pyramid. This familiar hierarchy of evidence in medical education, practice, and science serves to guide evaluations of the internal validity of randomized controlled trials, thereby establishing the "efficacy" of clinical interventions...
July 4, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28664622/subclinical-atherosclerosis-in-low-framingham-risk-hiv-patients
#10
Rafael León, Sergio Reus, Nicolás López, Irene Portilla, José Sánchez-Payá, Livia Giner, Vicente Boix, Esperanza Merino, Diego Torrús, Óscar Moreno, Joaquín Portilla
BACKGROUND: Pathogenesis of atherosclerosis is complex and differences between HIV-infected patients and general population cannot be completely explained by the higher prevalence of traditional cardiovascular risk factors. We aimed to analyse the association between inflammation and subclinical atherosclerosis in HIV patients with low Framingham risk score. MATERIALS AND METHODS: Case-control study. SETTING: outpatient Infectious Diseases clinic in a university hospital...
June 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28664600/liver-enzymes-are-not-directly-involved-in-atrial-fibrillation-a-prospective-cohort-study
#11
Rudolph Schutte, Peter H Whincup, Olia Papacosta, Lucy T Lennon, Peter W Macfarlane, Goya Wannamethee
BACKGROUND: Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation in men initially free of this heart condition. MATERIALS AND METHODS: We prospectively investigated change (delta) in liver enzymes and new-onset atrial fibrillation in a representative sample of 1428 men aged 60-79 years...
June 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28664568/circulating-microrna-in-patients-with-repaired-tetralogy-of-fallot
#12
Clare Tm Lai, Enders Ko Ng, Pak-Cheong Chow, Ava Kwong, Yiu-Fai Cheung
BACKGROUND: Emerging data suggest that heart-related microRNAs (miRs) may serve as circulating biomarkers of myocardial injury. We aimed to determine the circulating profile of miRs in patients with volume-overloaded right ventricles after repair of tetralogy (TOF). METHODS: A total of 104 TOF patients and 70 controls were recruited. The study was conducted into two phases: I) determination of circulating heart-related miRs described in left heart diseases (miR-1, miR-133a, miR208a, miR-208b and miR423-5p) by quantitative real time-PCR in 49 patients and 30 controls and followed by validation in an independent cohort of 55 patients and 40 controls; II) expression profiling of serum samples from 8 patients and 8 controls, followed by validation...
June 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28657113/high-burden-of-coronary-atherosclerosis-in-patients-with-cirrhosis
#13
Konstantin Kazankov, Kim Munk, Kristian Altern Øvrehus, Jesper Møller Jensen, Cecilie Brøckner Siggaard, Henning Grønbaek, Bjarne Linde Nørgaard, Hendrik Vilstrup
BACKGROUND: Population studies report increased cardiovascular mortality in patients with cirrhosis. Coronary artery disease may be a trait of end-stage liver disease, but whether it is frequent or extensive in cirrhosis in general is unknown. Thus, we aimed to assess the prevalence and extent of coronary artery disease in unselected cirrhosis patients. MATERIALS AND METHODS: Using coronary computed tomography angiography, we investigated 52 patients from all Child-Pugh classes and etiologies of cirrhosis without known cardiac disease for presence and severity of coronary artery disease in a cross-sectional design...
June 28, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28639412/the-role-of-microrna-5196-in-the-pathogenesis-of-systemic-sclerosis
#14
Marzena Ciechomska, Patryk Zarecki, Michal Merdas, Jerzy Swierkot, Ewa Morgiel, Piotr Wiland, Wlodzimierz Maslinski, Katarzyna Bogunia-Kubik
BACKGROUND: Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by tissue fibrosis and immune abnormalities. Recent evidence suggests that activated circulating monocytes from SSc patients play an important role in early stages of SSc pathogenesis due to enhanced expression of tissue inhibitor of metalloproteinases 1 (TIMP-1), IL-8 and reactive oxygen species (ROS) induction. However, the exact factors that contribute to chronic inflammation and subsequently fibrosis progression are still unknown...
June 21, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28621798/the-relationship-of-serum-adipokines-with-malnutrition-inflammation-score-in-hemodialysis
#15
Elham Alipoor, Ahmad Esmaillzadeh, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges Sadat Zahed, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND: Protein-energy wasting is a prevalent disorder in hemodialysis. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with recognized lipolytic effects and proposed role in metabolic homeostasis. This study was conducted to investigate the association of ZAG and ATGL concentrations with malnutrition inflammation score (MIS) and metabolic profile of patients with hemodialysis. MATERIALS AND METHODS: Eighty-eight patients under regular hemodialysis divided based on MIS to normal to mild wasting (NMW; n=35) or moderate wasting (MW; n=53) groups...
June 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28555728/platelet-distribution-width-as-the-prognostic-marker-in-coronary-bifurcation-treatment
#16
Adam Kern, Robert J Gil, Krystian Bojko, Ewa Sienkiewicz, Beata Januszko-Giergielewicz, Jerzy Górny, Jacek Bil
INTRODUCTION: Mean platelet volume (MPV) was proved to be a reliable prognostic factor in cardiac patients. However, platelet distribution width (PDW) was disclosed to be more specific marker of platelet reactivity. The aim of study was to evaluate whether baseline PDW value can predict the outcome in patients undergoing percutaneous coronary interventions (PCI) with drug-eluting stent implantation within coronary bifurcation lesions. MATERIAL AND METHODS: It was a two-center observational study, which included patients who underwent PCI within bifurcation lesions between January 2014 and December 2014...
May 28, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28556177/outcome-predictors-in-dilated-cardiomyopathy-or-myocarditis
#17
Friedhelm Kuethe, Marcus Franz, Christian Jung, Christiane Porrmann, Franziska Reinbothe, Peter Schlattmann, Renate Egerer, Gerhard Mall
BACKGROUND: The objective of this study was to identify parameters of prognostic relevance in patients presenting with chronic left ventricular dysfunction who underwent endomyocardial biopsy. MATERIALS AND METHODS: A total of 351 consecutive patients (age 47·7 ± 12·6 years, 281 male) with a chronic left ventricular dysfunction were enrolled. Endomyocardial biopsies were analysed by histopathology according to Dallas criteria and immunohistological WHO criteria...
May 27, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28556061/acetylsalicylic-acid-in-critically-ill-patients-a-cross-sectional-and-a-randomized-trial
#18
Christian Schoergenhofer, Eva-Luise Hobl, Michael Schwameis, Georg Gelbenegger, Thomas Staudinger, Gottfried Heinz, Walter S Speidl, Christian Zauner, Birgit Reiter, Irene Lang, Bernd Jilma
BACKGROUND: Despite decades of clinical use, the pharmacokinetics and the effects of acetylsalicylic acid (ASA) in critically ill patients remain ill-defined. We aimed to investigate the pharmacokinetics and the effects of different ASA formulations during critical illness. DESIGN: A cross-sectional study and a randomized, parallel-group trial were performed. Critically ill patients under chronic oral ASA treatment (100 mg enteric-coated) were screened for high 'on-treatment' platelet reactivity (HTPR) according to arachidonic acid-induced whole-blood aggregometry...
May 27, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28542805/downregulation-of-cholesteryl-ester-transfer-protein-by-glucocorticoids-a-randomised-study-on-hdl
#19
Jorien Werumeus Buning, Lidya G Dimova, Frank G Perton, Uwe J F Tietge, André P van Beek, Robin P F Dullaart
BACKGROUND: High density lipoprotein (HDL) cholesterol is not decreased in hypercortisolism despite high triglycerides, which may be ascribed to effects on the cholesteryl ester transfer protein (CETP) pathway. We explored if CETP mRNA expression is modulated by glucocorticoid treatment in vitro. Effects of doubling the hydrocortisone (HCT) replacement dose on plasma CETP activity, and HDL characteristics were tested in patients with secondary adrenal insufficiency. MATERIALS AND METHODS: Human THP-1 macrophages were incubated with corticosterone in vitro in the presence or absence of a liver X receptor (LXR) agonist, followed by determination of CETP mRNA levels by quantitative real-time PCR...
May 24, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28517037/serum-phosphate-is-related-to-adiposity-in-healthy-adults
#20
Emma O Billington, Greg D Gamble, Sarah Bristow, Ian R Reid
BACKGROUND: Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations. METHODS: Cross-sectional data from three independent cohorts, consisting of healthy adult males (Male Cohort, n = 323) and healthy postmenopausal women (Female Cohort 1, n = 185; and Female Cohort 2, n = 1471), are reported...
May 18, 2017: European Journal of Clinical Investigation
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