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European Journal of Clinical Investigation

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https://www.readbyqxmd.com/read/28425090/determinants-of-the-post-pericardiotomy-syndrome-a-systematic-review
#1
REVIEW
Dirk van Osch, Hendrik M Nathoe, Kirolos A Jacob, Pieter A Doevendans, Diederik van Dijk, Willem J Suyker, Jan M Dieleman
BACKGROUND: Post Pericardiotomy Syndrome (PPS) is a common complication following cardiac surgery, however the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of PPS in adult cardiac surgery patients. MATERIAL AND METHODS: Two independent investigators performed a systematic search in MEDLINE, EMBASE and the Cochrane Central Register...
April 20, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28415155/letter-to-the-editor-regarding-dounousi-e-et%C3%A2-al-intact-fgf23-and-%C3%AE-klotho-during-acute-inflammation-sepsis-in-ckd-patients-eur-j-clin-invest-2016-46-234-41
#2
Axel Schlitt, Urban Sester, Martina Sester, Sarah Seiler-Mussler, Vincent Brandenburg, Elke Schäffner, Gunnar H Heine
With interest we read the recent European Journal of Clinical Investigation paper entitled "Intact FGF23 and α-Klotho during acute inflammation/sepsis in CKD patients" by E. Dounousi and coworkers (1). In their article, the authors analyse the association between acute infection and plasma levels of the phosphaturic hormone fibroblast growth factor 23 (FGF-23). The physiological regulation of FGF-23 is not fully understood so far, and hence novel pathophysiological data are of importance. Particularly the link between FGF23 and inflammation is a growing field...
April 17, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28407234/mediterranean-diet-decreases-adolescent-waist-circumference
#3
Flora Bacopoulou, Georgios Landis, Anastasios Rentoumis, Artemis Tsitsika, Vasiliki Efthymiou
BACKGROUND: To explore the effects of a multicomponent-multilevel school-based educational intervention on the nutritional habits and abdominal obesity indices of a representative adolescent sample. MATERIALS AND METHODS: A representative sample of 1,610 adolescents aged 12-17 years in 23 public high schools of three municipalities in the Attica region in Greece, participated in a program funded by the European Union (August 2013-August 2014). Participants underwent dietary assessment with the use of the Mediterranean Diet Quality Index in children and adolescents (KIDMED), blood pressure assessment and screening for general and abdominal obesity by measuring body mass index, waist circumference (WC) and waist-to-height ratio (WHtR), at baseline and following a six-month school-based intervention...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28407232/observed-survival-benefit-of-therapeutic-hypothermia-re-analyzing-the-circ-trial
#4
Alexander Nürnberger, Harald Herkner, Fritz Sterz, Jan-Aage Olsen, Michael Lozano, Pierre M van Grunsven, Brooke E Lerner, David Persse, Reinhard Malzer, Marc A Brouwer, Mark Westfall, Chris M Souders, David T Travis, Ulrich R Herken, Lars Wik
BACKGROUND: Mild therapeutic hypothermia is argued being beneficial for outcome after cardiac arrest. MATERIALS AND METHODS: Retrospective analysis of Circulation Improving Resuscitation Care trial data to assess if therapeutic cooling to 33 ±1°C core temperature had an association with survival. Of 4,231 adult out-of-hospital cardiac arrests of presumed cardiac origin initially enrolled, eligibility criteria for therapeutic hypothermia were met by 1,812. Logistic regression was undertaken in a stepwise fashion to account for the impact on outcome of each significant difference and for the variable of interest between the groups...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28407216/real-world-stroke-prevention-strategies-in-nonvalvular-atrial-fibrillation-in-patients-with-renal-impairment
#5
Kadir Uğur Mert, Gurbet Özge Mert, Özcan Başaran, Osman Beton, Volkan Dogan, Mehmet Tekinalp, Ahmet Çağrı Aykan, Ezgi Kalaycıoğlu, Ismail Bolat, Onur Taşar, Özgen Şafak, Macit Kalçık, Mehmet Yaman, Cevat Kırma, Murat Biteker
BACKGROUND: The data regarding stroke prevention strategies in non-valvular atrial fibrillation (NVAF) is limited especially in patients with renal impairment (RI). We sought to evaluate management dilemmas in patients with concurrent NVAF and RI in RAMSES (ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies inTurkey) study. METHODS: We conducted a prospective, multicenter, nation-wide registry in NVAF patients in outpatient cardiology clinics. All consecutive patients with nonvalvular atrial fibrillation were enrolled in RAMSES Study (ClinicalTrials...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28382625/smoking-and-obesity-in-systemic-lupus-erythematosus-a-cross-sectional-study
#6
Versini Mathilde, Shmuel Tiosano, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Howard Amital
BACKGROUND: Both smoking and obesity have been demonstrated as risk factors in several autoimmune diseases. Little is known about the relationship between systemic lupus erythematosus (SLE) and both smoking and obesity. OBJECTIVES: To investigate the association between SLE, tobacco consumption and body mass index (BMI). MATERIALS AND METHODS: Using data from the largest Health Maintenance Organization (HMO) in Israel, the Clalit Health Services, we searched for an association between SLE, smoking and obesity...
April 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28380255/comparative-effects-of-the-restriction-method-in-two-large-observational-studies-of-body-mass-index-and-mortality-among-adults
#7
Katherine M Flegal, Barry I Graubard, Sang-Wook Yi
BACKGROUND: A method applied in some large studies of weight and mortality is to begin with a well-defined analytic cohort and use successive restrictions in order to control for methodologic bias and arrive at final analytic results. MATERIALS AND METHODS: Two observational studies of body mass index and mortality allow a comparative assessment of these restrictions in very large data sets. One was a meta-analysis of individual participant data with a sample size of 8 million...
April 5, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369870/antihyperglycemic-drugs-use-and-new-onset-atrial-fibrillation-in-elderly-patients
#8
Hung-Yi Chen, Fu-Yu Yang, Gwo-Ping Jong, Yi-Sheng Liou
BACKGROUND: Antihyperglycemic drugs have been linked to new-onset atrial fibrillation (NAF). However, the effect of the different classes of antihyperglycemic drugs on the development of NAF in elderly patients has not been well studied. In this study, we investigated the association between different classes of antihyperglycemic drugs and NAF in elderly patients. MATERIAL AND METHODS: This was a nested case-control study performed using the database of National Health Insurance Program in Taiwan...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369858/challenges-in-gluten-free-diet-in-coeliac-disease-prague-consensus
#9
REVIEW
Gabriel Samasca, Aaron Lerner, Anamaria Girbovan, Genel Sur, Iulia Lupan, Peter Makovicky, Torsten Matthias, Hugh J Freeman
BACKGROUND: New treatments in coeliac disease are being vigorously pursued to either replace or facilitate the difficult-tofollow gluten-free diet. DESIGN: The present review intends to summarise the challenges in gluten-free diet adherence during the transitional period, as reflected in the last Prague consensus, published in 2016. RESULTS: The honourable panel members recommended that dietary adherence and the consequences of nonadherence represent key components for discussion in the transitional period setting...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369799/effect-of-dental-pulp-stem-cells-in-mptp-induced-old-aged-mice-model
#10
Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Christopher Simon, Quan Fu Gan, Vui King Vincent-Chong, Vasudevan Mani, Kesavanarayanan Krishnan Selvarajan, Vellayan Subramaniam, Sabri Musa, Noor Hayaty Abu Kasim
Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic (DA-ergic) neurons in the substantia nigra (SN) and represent as a huge threat to the geriatric population. Cell-replacement therapies (CRTs) have been proposed as a promising strategy to slow down or replace neuronal loss. Among the widely available cell sources, dental pulp stem cells (DPSCs) portray as an attractive source primarily due to their neural crest origin, ease of tissue procurement and less ethical hurdles MATERIALS AND METHODS: We first demonstrated the in vitro differentiation ability of DPSCs towards DA-ergic-like cells before evaluating their neuro-protection/neuro-restoration capacities in MPTP-induced mice...
March 30, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28369867/alkaline-phosphatase-and-prognosis-in-patients-with-coronary-artery-disease
#11
Gjin Ndrepepa, Erion Xhepa, Siegmund Braun, Salvatore Cassese, Massimiliano Fusaro, Heribert Schunkert, Adnan Kastrati
BACKGROUND: The evidence on the association between alkaline phosphatase (ALP) and prognosis of patients with coronary artery disease (CAD) is limited. The aim of this study was to assess the association of ALP with the risk of mortality or coronary events in patients with CAD. MATERIALS AND METHODS: The study included 5540 patients with angiography-proven CAD treated with catheter-based coronary revascularization. Baseline ALP measurements were available for analysis in all patients...
March 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28299775/accuracy-of-adrenal-imaging-and-adrenal-venous-sampling-in-diagnosing-unilateral-primary-aldosteronism
#12
Roland Ladurner, Sandra Sommerey, Stefan Buechner, Anna Dietz, Christoph Degenhart, Klaus Hallfeldt, Julia Gallwas
INTRODUCTION: The correct differentiation between unilateral and bilateral adrenal involvement in patients with primary aldosteronism (PA) is of utmost importance to justify surgical treatment. The aim of this study was to determine the accuracy of adrenal imaging compared to adrenal venous sampling (AVS), histopathology and postoperative outcome. METHODS: The data of all patients with unequivocal AVS who underwent unilateral laparoscopic adrenalectomy for primary aldosteronism between May 2004 and April 2015 were entered in this retrospective study...
March 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28295229/nutrient-patterns-and-their-relationship-with-general-and-central-obesity-in-us-adults
#13
Mohsen Mazidi, Andre Pascal Kengne
BACKGROUND: Despite growing evidence on the associations between nutrient patterns and obesity, very few studies have examined the association between patterns of nutrient intake and obesity. OBJECTIVE: To identify major nutrient patterns in U.S. adults and investigate their association with general and central obesity. METHODS: National Health and Nutrition Examination Survey (NHANES) participants from 2005 to 2012 were included. General obesity was defined as body mass index ≥30 kg/m2, and central obesity as a waist circumference >102 cm for men and >88 cm for women...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28295225/the-association-between-systemic-lupus-erythematosus-and-valvular-heart-disease-an-extensive-data-analysis
#14
Abdulla Watad, Shmuel Tiosano, Noam Grysman, Doron Comaneshter, Arnon D Cohen, Yehuda Shoenfeld, Howard Amital
BACKGROUND: Association between antiphospholipid syndrome in systemic lupus erythematosus (SLE) and valvular heart disease (VHD) is well reported, but relatively few studies have been carried out to establish the linkage between VHD and SLE itself. We aimed to investigate link between VHD and SLE and to evaluate the association of diverse factors with VHD among these patients in a large-scale population-based study. MATERIALS AND METHODS: We used the databases of the largest state-mandated health service organization in Israel...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28294315/predictors-of-incident-obesity-phenotype-in-non-obese-healthy-adults
#15
Anita Eftekharzadeh, Golaleh Asghari, Sara Serahati, Farhad Hosseinpanah, Ali Azizi, Maryam Barzin, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: Despite their different cardiovascular consequences, little is known about predictors of metabolically healthy (MHO) and metabolically unhealthy (MUHO) obesity. This cohort study was designed to address this question in participants of the Tehran Lipid and Glucose Study. MATERIALS AND METHODS: Employing the Joint Interim Statement (JIS) metabolic syndrome criteria to define MHO/MUHO phenotypes, non-obese, otherwise healthy individuals, aged >20 years (n= 3489) were recruited and followed up for a median of 13...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28276576/delta-amino-levulinic-acid-dehydratase-gene-and-essential-tremor
#16
José A G Agúndez, Elena García-Martín, Hortensia Alonso-Navarro, Pedro Ayuso, Gara Esguevillas, Julián Benito-León, Sara Ortega-Cubero, Pau Pastor, Tomás López-Alburquerque, Félix Javier Jiménez-Jiménez
BACKGROUND/OBJECTIVE: Several reports found a relationship between increased serum lead levels and the risk for essential tremor (ET), especially in carriers of the minor allele of the single nucleotide polymorphism (SNP) rs1800435 in the aminolevulinate dehydratase (ALAD) gene, which is involved in the synthesis of heme groups. Our group reported decreased risk for ET in carriers of the minor alleles of the rs2071746 and rs1051308 SNPs in the heme-oxygenases 1 and 2 (HMOX1 and HMOX2), respectively, involved in heme metabolism...
March 9, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28226412/rage-polymorphisms-and-oxidative-stress-levels-in-hashimoto-s-thyroiditis
#17
Maria Giannakou, Katerina Saltiki, Emily Mantzou, Eleni Loukari, Georgios Philippou, Konstantinos Terzidis, Kiriaki Lili, Charalampos Stavrianos, Miltiades Kyprianou, Maria Alevizaki
BACKGROUND: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of this study was to investigate the possible role of two common RAGE polymorphisms (-429T>C, -374T>A) in Hashimoto's thyroiditis; in parallel, we studied oxidative stress levels. MATERIALS AND METHODS: A total of 300 consecutive euthyroid women were examined and classified into three groups: Hashimoto's thyroiditis with treatment (n = 96), Hashimoto's thyroiditis without treatment (n = 109) and controls (n = 95)...
February 22, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28186337/impaired-intestinal-cholecystokinin-secretion-a-fascinating-but-overlooked-link-between-coeliac-disease-and-cholesterol-gallstone-disease
#18
REVIEW
Helen H Wang, Min Liu, Xiaodan Li, Piero Portincasa, David Q-H Wang
BACKGROUND: Coeliac disease is a chronic, small intestinal, immune-mediated enteropathy caused by a permanent intolerance to dietary gluten in genetically predisposed individuals. Clinical studies have found that intestinal cholecystokinin secretion and gallbladder emptying in response to a fatty meal are impaired before coeliac patients start the gluten-free diet (GFD). DESIGN: However, it was never really appreciated whether coeliac disease is associated with gallstones because there were very few studies investigating the mechanism underlying the impact of coeliac disease on the pathogenesis of gallstones...
April 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28177528/correlation-of-platelet-to-lymphocyte-ratio-and-neutrophil-to-lymphocyte-ratio-with-thrombolysis-in-myocardial-infarction-frame-count-in-st-segment-elevation-myocardial-infarction
#19
Hossein Vakili, Mahin Shirazi, Mahsa Charkhkar, Isa Khaheshi, Mehdi Memaryan, Mohammadreza Naderian
BACKGROUND: Impaired coronary artery reflow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated with postintervention adverse effects. Thus, finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been introduced. In this study, we aimed to investigate correlation of PLR and NLR with thrombolysis in myocardial infarction (TIMI) frame count...
April 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28177519/methionine-35-sulphoxide-reduces-toxicity-of-a%C3%AE-in-red-blood-cell
#20
Cristiana Carelli-Alinovi, Francesco Misiti
BACKGROUND: The oxidation of methionine residue in position 35 of Ab to sulphoxide (Ab-sulphoxide) has the ability to deeply modify wild-type Ab 1-42 (Ab) neurotoxic action. Our previous studies suggest that in nucleated cells, lower toxicity of Ab-sulphoxide might result not from structural alteration, but from elevation of methionine sulphoxide reductase A (MsrA) activity and mRNA levels. DESIGN: On this basis, we hypothesised that red blood cell (RBC), a cell devoid almost completely of MsrA activity, shares with nucleated cells an antioxidant system induced by methionine 35 sulphoxide, responsible for the lower toxicity of Ab-sulphoxide in RBC...
April 2017: European Journal of Clinical Investigation
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