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European Journal of Clinical Investigation

Rocco Maurizio Zagari, Stefano Rabitti, Leonardo Henry Eusebi, Franco Bazzoli
BACKGROUND: Helicobacter pylori infection is still frequent in the community and all infected subjects should be offered an eradication therapy. Nowdays physicians have to face the challenge of antibiotic resistance in treating Helicobacter pylori infected individuals. AIM: This review provides an overview of current international guidelines and reports recent evidence from systematic reviews and clinical trials on the treatment of Helicobacter pylori infection, and should help physicians to better treat their patients...
November 16, 2017: European Journal of Clinical Investigation
Sinan Kardeş, Mine Karagülle, İlker Durak, Aslıhan Avcı, Müfit Zeki Karagülle
BACKGROUND: Few studies examining the association between oxidative stress and clinical parameters or disease activity in rheumatoid arthritis (RA) patients are available. Therefore, the objective of this study was to test whether oxidative stress has any association with clinical parameters and disease activity in patients with RA. MATERIALS AND METHODS: In this post hoc cross-sectional study, 45 RA patients treated with traditional disease-modifying antirheumatic drugs (DMARDs) ± low-dose glucocorticoids ± non-steroidal analgesics for at least 3 months were analyzed...
November 16, 2017: European Journal of Clinical Investigation
Luca Liberale, Fabrizio Montecucco, Aldo Bonaventura
In November 2017, the Council of the European Society of Clinical Investigation (ESCI) evaluated all basic research articles published in the European Journal of Clinical Investigation (EJCI) from November 2016 to October 2017. In the final selection round, five articles of outstanding quality have been selected based on their scientific impact, quality, and novelty [1-5]. Among finalists, the article by Jorien Werumeus Buning and Lidya G. Dimova et al. entitled "Downregulation of cholesteryl ester transfer protein by glucocorticoids: a randomized study on HDL" obtained the highest consideration by the ESCI Council and has been judged as the Best Basic Research Article published in EJCI [5]...
November 13, 2017: European Journal of Clinical Investigation
Federico Carbone, Fabrizio Montecucco, Fabio Rigamonti
As already done in the past three years, the Council of the European Society of Clinical Investigation (ESCI) will award at the next Scientific Meeting in Barcelona (May 30(th) -Juin 1(st) 2018) the best clinical research article published in the European Journal of Clinical Investigation (EJCI) from November 2016 to October 2017. In the final selection round, five clinical articles were selected based on their outstanding scientific value [1-5]. Among those finalists, the article by Caironi and co-workers obtained the highest consideration and was selected as the winner of the 2018 ESCI Award for the Best EJCI Basic Research Article [3]...
November 13, 2017: European Journal of Clinical Investigation
Yen-Yu Lu, Wen-Shiann Wu, Yung-Kuo Lin, Chen-Chuan Cheng, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia, and pulmonary veins (PVs) play a critical role in triggering AF. Angiotensin (Ang)-(1-7) regulates calcium (Ca(2+) ) homeostasis and also plays a critical role in cardiovascular pathophysiology. However, the role of Ang-(1-7) in PV arrhythmogenesis remains unclear. MATERIALS AND METHODS: Conventional microelectrodes, whole-cell patch-clamp, and the Fluo-3 fluorimetric ratio technique were used to record ionic currents and intracellular Ca(2+) in isolated rabbit PV preparations, and in single isolated PV cardiomyocytes, before and after administration of Ang-(1-7)...
November 12, 2017: European Journal of Clinical Investigation
Petrus J W Naudé, Doortje W Dekens, Ulrich L M Eisel, Izaak den Daas, Peter P De Deyn
BACKGROUND: Neutrophil Gelatinase-Associated Lipocalin (NGAL) is an inflammatory protein with gaining increasing interest for its use as marker in blood and cerebrospinal fluid (CSF) for several chronic diseases. Its biochemical properties make it an attractive marker. However, changes in blood and CSF NGAL concentrations during the diurnal rhythm in the elderly are unknown. This information is important for its optimal use as marker in studies with older people. METHODS: Serial paired plasma and CSF samples were obtained from 8 healthy elderly males over a 30 hour period...
October 30, 2017: European Journal of Clinical Investigation
Sit-Yee Kwok, Susanna So-Shan Yeung, Vivian Wing-Yi Li, Yiu-Fai Cheung
BACKGROUND: Emerging data suggest impaired biventricular function in adults late after repair of ventricular septal defect (VSD). We assessed and compared right (RV) and left ventricular (LV) mechanics in adolescents and adults after surgical closure of doubly committed subarterial and perimembranous VSDs. METHODS: A total of 75 subjects were studied: 29 patients after subarterial VSD repair (group I), 17 patients after perimembranous VSD repair (group II) and 29 age-matched controls (group III)...
October 30, 2017: European Journal of Clinical Investigation
Michele Correale, Lucia Tricarico, Armando Ferraretti, Ilenia Monaco, Morena Concilio, Giuseppina Padovano, Gianfranco Acanfora, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: Right heart catheterization (RHC) is usually required to confirm the diagnosis of pulmonary artery hypertension (PAH). As an invasive test, RHC may be associated with possible complications; so, non-invasive parameters able to predict PAH at RHC would be extremely useful. AIM: To ascertain possible correlations between cardiopulmonary exercise testing (CPET) and hemodynamic parameters at RHC indicative of PH. METHODS: Thirty-six consecutive outpatients with suspect of PAH underwent CPET and RHC; the intercept of ventilation (VEint) on the VE vs...
October 30, 2017: European Journal of Clinical Investigation
Yair Molad
We hereby respond to the Letter to the Editor of Gkougkourelas et al. with respect to their concern about the comparability of blood value of soluble TREM-1 in healthy control samples found in our studies [1, 2]. Indeed, we're aware of the inconsistent results of sTREM-1 level found in 2 different control groups. This is explained by the different commercial ELISA kits we've used (DuoSet R&D Systems Inc., Minneapolis, USA and Abcam, Cambridge, MA, USA, respectively). This article is protected by copyright...
October 19, 2017: European Journal of Clinical Investigation
I Gkougkourelas, K Tselios, P Boura
Soluble Triggering Receptor Expressed on Myelocytes 1 (sTREM-1) is a promising innate immunity biomarker that may be able to differentiate infectious from aseptic (non-infectious) systemic inflammation. Ambiguous results on its discriminative value have been reported by different studies. In addition, controversy still exists regarding its reference values in normal individuals, further impeding solid conclusions. This article is protected by copyright. All rights reserved.
October 19, 2017: European Journal of Clinical Investigation
Frank Lloyd Dini, Erberto Carluccio, Fabrizio Montecucco, Gian Marco Rosa, Paolo Fontanive
BACKGROUND: Chronic heart failure (HF) is a relevant and growing public health problem. Although the prognosis has recently improved, it remains a lethal disease, with a mortality that equals or exceeds that of many malignancies. Furthermore, chronic HF is costly, representing a large and growing drain on healthcare resources. METHODS: This narrative review is based on the material searched for and obtained via PubMed up to May 2017. The search terms we used were: "heart failure, echocardiography, natriuretic peptides" in combination with "treatment, biomarkers, guidelines"...
October 16, 2017: European Journal of Clinical Investigation
Jun-Jun Yeh, Cheng-Li Lin, Wu-Huei Hsu
BACKGROUND: We conducted a cohort study to determine the relationship between enterovirus (EV) infection and asthma. MATERIALS AND METHODS: From the National Health Insurance Research Database of Taiwan, we identified patients who received a new diagnosis of asthma and concurrent treatment between January 2000 and December 2011 (EV cohort: n = 208,213; non-EV cohort: n = 208,213). Cox proportional hazards regression analysis was performed to determine and compare the adjusted hazard ratios (aHRs) of asthma between these 2 cohorts...
October 15, 2017: European Journal of Clinical Investigation
Sophie Mavrogeni, Antigoni Papavasiliou, Katerina Giannakopoulou, George Markousis-Mavrogenis, Maria Roser Pons, Evangelos Karanasios, Ioannis Nikas, George Papadopoulos, Genovefa Kolovou, George P Chrousos
Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by progressive, irreversible loss of cardiac and skeletal muscular function. Muscular enlargement in DMD is attributed to oedema, due to the increased cytoplasmic Na+ concentration. The aim in this review is to present the current experience and emphasize the role of cardiovascular magnetic resonance (CMR) in the diagnosis of this condition. DMD patients' survival depends on ventilatory assistance, as respiratory muscle dysfunction was the most common cause of death in the past...
October 13, 2017: European Journal of Clinical Investigation
Konstantinos Z Vardakas, Kyriakos K Trigkidis, Katerina N Apiranthiti, Matthew E Falagas
SCOPE: To study the factors associated with mortality in hospitalized patients with community acquired pneumonia (CAP) treated with monotherapy or combination therapy. METHODS: PubMed and Scopus were searched. Patients receiving macrolides, β-lactams and fluoroquinolones, as monotherapy or in combination were included. Meta-analyses and meta-regressions were performed. RESULTS: Fifty four studies were included. Monotherapy was not associated with higher mortality than combination (RR 1...
October 13, 2017: European Journal of Clinical Investigation
Sophie Mavrogeni, Roser Pons, Ioannis Nikas, George Papadopoulos, Dimitrios A Verganelakis, Genovefa Kolovou, George P Chrousos
Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by progressive and irreversible loss of muscular function. As muscular disease progresses, the repair mechanisms cannot compensate for cellular damage, leading inevitably to necrosis and progressive replacement by fibrous and fatty tissue. Cardiomyopathy and respiratory failure are the main causes of death in DMD. In addition to the well-described muscle and heart disease, cognitive dysfunction affects around 30% of DMD boys. Myocardial fibrosis, assessed by late gadolinium enhancement (LGE), using cardiovascular magnetic resonance imaging (CMR), is an early marker of heart involvement in both DMD patients and female carriers...
October 5, 2017: European Journal of Clinical Investigation
Eray Eroglu, Hilmi U Unal, Aydin Guclu, Ismail Kocyigit, Murat Karaman, Mutlu Saglam, Mustafa Gezer, Ahmet Tas, Gokmen Zararsiz, Tayfun Eyileten, İbrahim Aydin, Yusuf Oguz, Ozkan Gungor, Mahmut I Yilmaz
BACKGROUND: Profilin-1 is a ubiquitous, actin-binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin-1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1-5 CKD. MATERIALS AND METHODS: Serum concentrations of profilin-1 levels were determined by enzyme-linked immunosorbent assay...
October 5, 2017: European Journal of Clinical Investigation
Tianwei Qian, Xinxin Li, Mengya Zhao, Xun Xu
BACKGROUND: Combined treatment with intravitreal anti-vascular endothelial growth factor (anti-VEGF) and verteporfin photodynamic therapy (PDT) is widely used for patients with polypoidal choroidal vasculopathy (PCV), although clinical evidence regarding the therapeutic efficacy and safety of such treatment remains lacking. DESIGN/METHODS: We performed a meta-analysis of previously reported studies comparing combination treatment, PDT monotherapy, and anti-VEGF monotherapy...
October 5, 2017: European Journal of Clinical Investigation
John P A Ioannidis
Greece has undergone a distressing crisis that has taken a heavy toll, devaluing lives of individuals and functions of society at large. Besides the economic meltdown, there has been an even worse crisis of values. The country currently occupies a low rank in the WHO Happiness Index (1) (99(th) in 2016 and 87(th) in 2017), not so much because of worsening ranking in healthy life expectancy (still ranked 24(th) in the world in 2017) or even wealth (still ranked 44(th) in GDP per capita), but because of mediocre ranking in social support (ranked 80(th) ) and extremely low rankings in freedom to make life choices (ranked 150(th) among 155 countries), generosity (ranked 155(th) , i...
October 5, 2017: European Journal of Clinical Investigation
Pia Thisted Dinesen, Thomas Andersen Rix, Albert Marni Joensen, Anne Tjønneland, Søren Lundbye-Christensen, Kim Overvad, Erik Berg Schmidt
OBJECTIVES: The aim of the present study was to investigate the association between adipose tissue content of total saturated fatty acids including myristic (C14:0), palmitic (C16:0) and stearic (C18:0) acid, as a measure of exposure to saturated fatty acids and the risk of incident atrial fibrillation. MATERIALS AND METHODS: A total of 57,053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline and this was analysed for saturated fatty acids content by gas chromatography...
September 14, 2017: European Journal of Clinical Investigation
Greggory R Davis, Tiffany Deville, Joshua Guillory, David Bellar, Arnold G Nelson
BACKGROUND: Determining predictive markers for the development of type 2 diabetes (T2D), particularly in young individuals, offers immense potential benefits in preventative medicine. Previous research examining serum fibroblast growth factor 21 (FGF21) in humans has revealed equivocal relationships with clinical markers of metabolic dysfunction. However, it is unknown to what extent, if any, first-degree family history of T2D (mother or father of the participant diagnosed with T2D) level affects serum FGF21 levels...
September 7, 2017: European Journal of Clinical Investigation
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