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European Journal of Clinical Investigation

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https://www.readbyqxmd.com/read/28299775/accuracy-of-adrenal-imaging-and-adrenal-venous-sampling-in-diagnosing-unilateral-primary-aldosteronism
#1
Roland Ladurner, Sandra Sommerey, Stefan Buechner, Anna Dietz, Christoph Degenhart, Klaus Hallfeldt, Julia Gallwas
INTRODUCTION: The correct differentiation between unilateral and bilateral adrenal involvement in patients with primary aldosteronism (PA) is of utmost importance to justify surgical treatment. The aim of this study was to determine the accuracy of adrenal imaging compared to adrenal venous sampling (AVS), histopathology and postoperative outcome. METHODS: The data of all patients with unequivocal AVS who underwent unilateral laparoscopic adrenalectomy for primary aldosteronism between May 2004 and April 2015 were entered in this retrospective study...
March 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28295229/nutrient-patterns-and-their-relationship-with-general-and-central-obesity-in-us-adults
#2
Mohsen Mazidi, Andre Pascal Kengne
BACKGROUND: Despite growing evidence on the associations between nutrient patterns and obesity, very few studies have examined the association between patterns of nutrient intake and obesity. OBJECTIVE: To identify major nutrient patterns in U.S. adults and investigate their association with general and central obesity. METHODS: National Health and Nutrition Examination Survey (NHANES) participants from 2005 to 2012 were included. General obesity was defined as body mass index ≥30 kg/m2, and central obesity as a waist circumference >102 cm for men and >88 cm for women...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28295225/the-association-between-sle-and-valvular-heart-disease-an-extensive-data-analysis
#3
Abdulla Watad, Shmuel Tiosano, Noam Grysman, Doron Comaneshter, Arnon D Cohen, Yehuda Shoenfeld, Howard Amital
BACKGROUND: Association between anti-phospholipid syndrome (APS) in systemic lupus erythematosus (SLE) and valvular heart disease (VHD) is well reported, but relatively few studies have been done to establish the linkage between VHD and SLE itself. OBJECTIVES: To investigate the link between VHD and SLE and to evaluate the association of diverse factors with VHD among these patients in a large-scale population-based study. METHODS: We used the databases of the largest state-mandated health service organization in Israel...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28294315/predictors-of-incident-obesity-phenotype-in-non-obese-healthy-adults
#4
Anita Eftekharzadeh, Golaleh Asghari, Sara Serahati, Farhad Hosseinpanah, Ali Azizi, Maryam Barzin, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: Despite their different cardiovascular consequences, little is known about predictors of metabolically healthy (MHO) and metabolically unhealthy (MUHO) obesity. This cohort study was designed to address this question in participants of the Tehran Lipid and Glucose Study. MATERIALS AND METHODS: Employing the Joint Interim Statement (JIS) metabolic syndrome criteria to define MHO/MUHO phenotypes, non-obese, otherwise healthy individuals, aged >20 years (n= 3489) were recruited and followed up for a median of 13...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28276576/delta-amino-levulinic-acid-dehydratase-gene-and-essential-tremor
#5
José A G Agúndez, Elena García-Martín, Hortensia Alonso-Navarro, Pedro Ayuso, Gara Esguevillas, Julián Benito-León, Sara Ortega-Cubero, Pau Pastor, Tomás López-Alburquerque, Félix Javier Jiménez-Jiménez
BACKGROUND/OBJECTIVE: Several reports found a relationship between increased serum lead levels and the risk for essential tremor (ET), especially in carriers of the minor allele of the single nucleotide polymorphism (SNP) rs1800435 in the aminolevulinate dehydratase (ALAD) gene, which is involved in the synthesis of heme groups. Our group reported decreased risk for ET in carriers of the minor alleles of the rs2071746 and rs1051308 SNPs in the heme-oxygenases 1 and 2 (HMOX1 and HMOX2), respectively, involved in heme metabolism...
March 9, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28226412/rage-polymorphisms-and-oxidative-stress-levels-in-hashimoto-s-thyroiditis
#6
Maria Giannakou, Katerina Saltiki, Emily Mantzou, Eleni Loukari, Georgios Philippou, Konstantinos Terzidis, Kiriaki Lili, Charalampos Stavrianos, Miltiades Kyprianou, Maria Alevizaki
BACKGROUND: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of this study was to investigate the possible role of two common RAGE polymorphisms (-429T>C, -374T>A) in Hashimoto's thyroiditis; in parallel, we studied oxidative stress levels. MATERIALS AND METHODS: A total of 300 consecutive euthyroid women were examined and classified into three groups: Hashimoto's thyroiditis with treatment (n = 96), Hashimoto's thyroiditis without treatment (n = 109) and controls (n = 95)...
February 22, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28186337/impaired-intestinal-cholecystokinin-secretion-a-fascinating-but-overlooked-link-between-celiac-disease-and-cholesterol-gallstone-disease
#7
REVIEW
Helen H Wang, Min Liu, Xiaodan Li, Piero Portincasa, David Q-H Wang
BACKGROUND: Celiac disease is a chronic, small intestinal, immune-mediated enteropathy caused by a permanent intolerance to dietary gluten in genetically predisposed individuals. Clinical studies have found that intestinal cholecystokinin secretion and gallbladder emptying in response to a fatty meal are impaired before celiac patients start the gluten-free diet (GFD). DESIGN: However, it was never really appreciated whether celiac disease is associated with gallstones because there were very few studies investigating the mechanism underlying the impact of celiac disease on the pathogenesis of gallstones...
February 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28177528/correlation-of-platelet-to-lymphocyte-ratio-plr-and-neutrophil-to-lymphocyte-ratio-nlr-with-timi-frame-count-in-stemi
#8
Hossein Vakili, Mahin Shirazi, Mahsa Charkhkar, Isa Khaheshi, Mehdi Memaryan, Mohammadreza Naderian
BACKGROUND: Impaired coronary artery reflow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated with post-intervention adverse effects. Thus finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, Platelet-to -Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) have been introduced. In the present study, we aimed to investigate correlation of PLR and NLR with Thrombolysis In Myocardial Infarction (TIMI) frame count...
February 8, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28177519/methionine-35-sulfoxide-reduces-toxicity-of-a%C3%AE-in-red-blood-cell
#9
Cristiana Carelli-Alinovi, Francesco Misiti
The oxidation of Methionine residue in position 35 of Aβ to sulfoxide (Aβ-sulfoxide) has the ability to deeply modify wild type Aβ 1-42 (Aβ) neurotoxic action. Our previous studies suggest that in nucleated cells lower toxicity of Aβ-sulfoxide might result not from structural alteration, but from elevation of Methionine sulfoxide reductase A (MsrA) activity and mRNA levels. On these basis, we hypothesised that red blood cell (RBC), a cell devoid almost completely of MsrA activity, share with nucleated cells an antioxidant system induced by methionine 35 sulfoxide, responsible for the lower toxicity of Aβ-sulfoxide in RBC...
February 8, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28156006/applicability-of-extracellular-vesicles-in-clinical-studies
#10
Domen Vozel, Bojana Uršič, Judita Lea Krek, Roman Štukelj, Veronika Kralj-Iglič
BACKGROUND: Extracellular vesicles (EVs) are submicron cellular fragments that mediate intercellular communication. EVs have in the last decade attracted major interest as biomarkers or platforms for biomarkers of health and disease. To better understand the reasons why despite great expectations and considerable effort, EV-based methods have not yet been introduced into clinical practice, we present a systematic analysis of published results of clinical studies. MATERIALS AND METHODS: Clinical studies on populations of body fluid samples, published from 2010 to including 2015, applying centrifugation of fluid human samples with centrifuge accelerations up to about 25 000 g and flow cytometry for detection of EVs were analysed with respect to statistical significance (p), statistical power (P), clinical significance (CS), defined as the difference between the means divided by the sum of standard deviations, and size of the populations (Nmin ), defined as the number of samples in the smaller group...
February 3, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28155994/pancreatic-stone-protein-and-soluble-cd25-for-infection-and-sepsis-in-an-emergency-department
#11
Luis García de Guadiana-Romualdo, Mario Berger, Enrique Jiménez-Santos, Sergio Rebollo-Acebes, Roberto Jiménez-Sánchez, Patricia Esteban-Torrella, Ana Hernando-Holgado, Alejandro Ortín-Freire, María Dolores Albaladejo-Otón
BACKGROUND: Infection is a common problem in Emergency Departments (ED) and is associated with high mortality, morbidity and costs. Identifying infection in ED patients can be challenging. Biomarkers can facilitate its diagnosis, enabling an early management and improving outcomes. In the critical care setting, two emerging biomarkers, pancreatic stone protein (PSP) and soluble CD25 (sCD25), have demonstrated to be useful for diagnosis of sepsis. We aimed to assess the diagnostic value of these biomarkers, in comparison to procalcitonin (PCT), for infection and sepsis in an ED population with suspected infection...
February 3, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28144944/erythrocyte-bound-apolipoprotein-b-in-atherosclerosis-and-mortality
#12
Marijke A de Vries, Selvetta S van Santen, Boudewijn Klop, Noëlle van der Meulen, Marjolein van Vliet, Gert-Jan M van de Geijn, Ellen M van der Zwan-van Beek, Erwin Birnie, Anho H Liem, Wouter W de Herder, Manuel Castro Cabezas
BACKGROUND: The binding of apolipoprotein (apo) B-containing lipoproteins to circulating erythrocytes (ery-apoB) is associated with a decreased prevalence of atherosclerosis. In this study, we evaluated ery-apoB as a possible prognostic factor in cardiovascular events and all-cause mortality, in a prospective cohort study. MATERIALS AND METHODS: Ery-apoB was measured by flow cytometry in subjects with and without cardiovascular disease (CVD). The primary endpoint was the cardiovascular event rate...
February 1, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28103386/paraoxonase-1-activity-is-related-to-trichinella-spiralis-induced-hepatitis-in-rats
#13
Ayman Samir Farid, Eman Mohamed Fath, Shogo Mido, Nariaki Nonaka, Yoichiro Horii
BACKGROUND: Little is known about the potential adverse effects of a chronic zoonotic nematode Trichinella spiralis infection on hepatic inflammation and its relationship to paraoxonase (PON)-1 and butyrylcholinesterase (BuChE) activities. Therefore, we aimed to examine the effects of T. spiralis infection on hepatic synthesis of PON1. METHODS: Wistar rats were infected with 2500 first-stage larvae (L1) of T. spiralis, and serum PON1 and BuChE activities were evaluated...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28102901/risk-of-arrhythmic-death-in-ischemic-heart-disease-a-prospective-controlled-observer-blind-risk-stratification-over-10%C3%A2-years
#14
Thomas Pezawas, André Diedrich, David Robertson, Robert Winker, Bernhard Richter, Li Wang, Herwig Schmidinger
BACKGROUND: Risk of arrhythmic death is considered highest in ischemic heart disease with severe left ventricular ejection fraction (LVEF) reduction. Non-invasive testing should improve decision-making of prophylactic defibrillator (ICD) implantation. DESIGN: We enrolled 120 patients with ischemic heart disease and LVEF < 50% and 30 control subjects without ischemic heart disease and normal LVEF. An initial assessment, a second assessment after 3 years and a final follow-up comprised of pharmacological baroreflex testing (BRS), short-term spectral [low-frequency (LF) to high-frequency (HF) ratio] and long-term time-domain analysis of heart rate variability (SDNN), exercise Microvolt T-wave alternans (MTWA) and others...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28102898/a-composite-autonomic-index-as-unitary-metric-for-heart-rate-variability-a-proof-of-concept
#15
Roberto Sala, Mara Malacarne, Nadia Solaro, Massimo Pagani, Daniela Lucini
BACKGROUND: This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from heart rate variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting. MATERIALS AND METHODS: Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n = 1593, age 39 ± 13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28075490/soluble-transferrin-receptor-and-risk-of-type-2-diabetes-in-the-obese-and-nonobese
#16
José C Fernández-Cao, Victoria Arija, Núria Aranda, Josep Basora, Javier Diez-Espino, Ramón Estruch, Montse Fitó, Dolores Corella, Jordi Salas-Salvadó
BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. DESIGN: A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www...
January 11, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28074555/paediatric-stress-from-neuroendocrinology-to-contemporary-disorders
#17
REVIEW
Stavroula Stavrou, Nicolas C Nicolaides, Elena Critselis, Christina Darviri, Evangelia Charmandari, George P Chrousos
BACKGROUND: Stress is defined as a state of threatened or perceived as threatened homeostasis. A broad spectrum of extrinsic or intrinsic, real or perceived stressful stimuli, called 'stressors', activates a highly conserved system, the 'stress system', which adjusts homeostasis through central and peripheral neuroendocrine responses. Inadequate, excessive or prolonged adaptive responses to stress may underlie the pathogenesis of several disease states prevalent in modern societies. The development and severity of these conditions primarily depend on the genetic vulnerability of the individual, the exposure to adverse environmental factors and the timing of the stressful event(s), given that prenatal life, infancy, childhood and adolescence are critical periods characterized by increased vulnerability to stressors...
January 11, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28042671/monte-carlo-decision-curve-analysis-using-aggregate-data
#18
Iztok Hozo, Athanasios Tsalatsanis, Benjamin Djulbegovic
BACKGROUND: Decision curve analysis (DCA) is an increasingly used method for evaluating diagnostic tests and predictive models but its application requires individual patient data. The Monte Carlo (MC) method can be used to simulate probabilities and outcomes of individual patients and offers an attractive option for application of DCA. METHODS: We constructed a MC decision model to simulate individual probabilities of outcomes of interest. These probabilities were contrasted against the threshold probability at which a decision-maker is indifferent between key management strategies: treat all, treat none, or use predictive model to guide treatment...
January 2, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28036122/soluble-st2-predicts-1-year-outcome-in-patients-undergoing-transcatheter-aortic-valve-implantation-tavi
#19
Bernhard Wernly, Michael Lichtenauer, Peter Jirak, Sarah Eder, Christian Reiter, Jürgen Kammler, Alexander Kypta, Christian Jung, Uta C Hoppe, Ulf Landmesser, Hans-Reiner Figulla, Alexander Lauten
INTRODUCTION: Soluble ST2 (sST2) has been introduced as a novel biomarker in patients suffering from heart failure for risk stratification. In this study we sought to investigate whether sST2 is useful for risk stratification and prediction of mortality in patients undergoing transcatheter aortic valve implantation (TAVI). MATERIALS AND METHODS: 274 patients undergoing TAVI were included in this study (149 female; age 80.50±0.51 years; EUROSCORE 25±1; STS Score 3...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28036121/study-of-the-anti-jcv-antibody-levels-in-a-spanish-multiple-sclerosis-cohort
#20
María I Dominguez-Mozo, Macarena Rus, Jose L Santiago, Guillermo Izquierdo, Ignacio Casanova, Victoria Galan, M Angel Garcia-Martinez, Ana M Arias-Leal, Marta García-Montojo, Silvia Pérez-Pérez, Rafael Arroyo, Roberto Alvarez-Lafuente
One of the risk factor to develop progressive multifocal leukoencephalopathy (PML) among natalizumab-treated patients is the presence and high levels of anti-JCV antibodies. Our purpose was to test the association of different clinical and demographic variables with the presence and levels of anti-JCV antibodies in a Spanish cohort of multiple sclerosis (MS) patients during natalizumab treatment MATERIALS AND METHODS: All MS patients from two hospitals with at least one measure of the anti-JCV antibodies levels (2011-2014) were recruited, among them two PML cases...
December 30, 2016: European Journal of Clinical Investigation
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