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Atherosclerosis

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https://www.readbyqxmd.com/read/28438319/do-we-really-need-another-individual-coronary-plaque-characterization-measurement
#1
EDITORIAL
Nishant R Shah, Michael K Cheezum, Sadako Motoyama, Yiannis S Chatzizisis
No abstract text is available yet for this article.
April 15, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28434555/phase-2-clinical-trials-with-k-877-pemafibrate-a-promising-selective-ppar-%C3%AE-modulator-for-treatment-of-combined-dyslipidemia
#2
EDITORIAL
Germán Camejo
No abstract text is available yet for this article.
April 15, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28412650/comparative-effects-of-cholesteryl-ester-transfer-protein-inhibition-statin-or-ezetimibe-on-lipid-factors-the-accentuate-trial
#3
Stephen J Nicholls, Kausik K Ray, Christie M Ballantyne, Lauren A Beacham, Debra L Miller, Giacomo Ruotolo, Steven E Nissen, Jeffrey S Riesmeyer
BACKGROUND AND AIMS: The optimal approaches to management of patients treated with moderate statin doses on lipid parameters are unknown. The ACCENTUATE study aimed to compare the effects of adding the cholesteryl ester transfer protein inhibitor (CETP) evacetrapib, ezetimibe or increasing statin dose in atorvastatin-treated high-vascular risk patients on lipid parameters. METHODS: 366 patients with atherosclerotic cardiovascular disease (ASCVD) and/or diabetes were treated with atorvastatin 40 mg/day for 28 days prior to randomization to atorvastatin 40 mg plus evacetrapib 130 mg, atorvastatin 80 mg, atorvastatin 40 mg plus ezetimibe 10 mg or atorvastatin 40 mg plus placebo, daily for 90 days at 64 centers in the United States...
April 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28411951/reply-to-considerations-about-prevalence-of-hypertension-and-hypertension-phenotypes-by-age-and-gender-among-schoolchildren-in-greece-the-healthy-growth-study
#4
LETTER
Kalliopi Karatzi, Athanase D Protogerou, George Moschonis, Christiana Tsirimiagou, Odysseas Androutsos, George P Chrousos, Christos Lionis, Yannis Manios
No abstract text is available yet for this article.
April 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28416256/youth-psychological-distress-and-intermediary-markers-of-risk-for-cvd-the-emerging-field-of-pediatric-psychocardiology
#5
EDITORIAL
Lisa S Olive
No abstract text is available yet for this article.
April 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28400053/proprotein-convertase-furin-pcsk3-and-atherosclerosis-new-insights-and-potential-therapeutic-targets
#6
REVIEW
Kun Ren, Ting Jiang, Xi-Long Zheng, Guo-Jun Zhao
Furin, a member of the mammalian proprotein convertases family, can promote the proteolytic maturation of proproteins. It is known that furin is predominantly present in certain cell types of human atherosclerotic lesions and neointima in animal models, including vascular smooth muscle cells, endothelial cells and mononuclear inflammatory cells. Evidence suggests that furin participates in the initiation and progression of atherosclerosis through regulation of lipid and cholesterol metabolism, inflammatory response, blood pressure and the formation of atherosclerotic lesions...
April 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28411494/fibroblast-growth-factor-23-as-a-predictor-of-cardiovascular-and-all-cause-mortality-in-prospective-studies
#7
Zhexue Qin, Xi Liu, Mingbao Song, Quan Zhou, Jie Yu, Baoshang Zhou, Yazhou Wu, Yongming He, Lan Huang
BACKGROUND AND AIMS: The prognostic value of fibroblast growth factor 23 (FGF23) for mortality remains controversial. We performed a meta-analysis of cohort studies to examine the controversial relationship between FGF23 and mortality. METHODS: PubMed, EMBASE, the Cochrane Library databases and reference bibliographies were searched through September 2016 to identify prospective cohort studies with relative risks (RRs) and 95% confidence intervals (CIs) for FGF23 and mortality...
April 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28396038/severe-reduction-of-blood-lysosomal-acid-lipase-activity-in-cryptogenic-cirrhosis-a-nationwide-multicentre-cohort-study
#8
Francesco Angelico, Stefano Ginanni Corradini, Daniele Pastori, Silvia Fargion, Anna Ludovica Fracanzani, Mario Angelico, Luigi Bolondi, Giulia Tozzi, Pietro Luigi Pujatti, Giancarlo Labbadia, Gino Roberto Corazza, Maurizio Averna, Francesco Perticone, Giuseppe Croce, Marcello Persico, Tommaso Bucci, Francesco Baratta, Licia Polimeni, Maria Del Ben, Francesco Violi
BACKGROUND AND AIMS: Blood lysosomal acid lipase (LAL) is reduced in non-alcoholic steatohepatitis, which is the major cause of cryptogenic cirrhosis (CC); few data on LAL activity in CC do exist. We investigated LAL activity in a cohort of patients with liver cirrhosis. METHODS: This is a multicentre cohort study including 274 patients with liver cirrhosis of different aetiology from 19 centres of Internal Medicine, Gastroenterology and Hepatology distributed throughout Italy...
March 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28390656/sequelae-of-cardiovascular-risk-factors-similarities-and-differences
#9
EDITORIAL
Johann Auer, Lisa Auer
No abstract text is available yet for this article.
March 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28390655/effect-of-spontaneous-changes-in-dietary-components-and-lipoprotein-a-levels-data-from-the-brisighella-heart-study
#10
LETTER
Federica Fogacci, Arrigo F G Cicero, Sergio D'Addato, Marina Giovannini, Claudio Borghi
No abstract text is available yet for this article.
March 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28389015/current-challenges-on-circulating-progenitor-cells-could-their-number-predict-oncoming-diseases
#11
EDITORIAL
Giuseppe Mandraffino, Valentina Cairo, Antonino Saitta
No abstract text is available yet for this article.
March 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28437675/whole-blood-sequencing-reveals-circulating-microrna-associations-with-high-risk-traits-in-non-st-segment-elevation-acute-coronary-syndrome
#12
Alice Wang, Lydia Coulter Kwee, Elizabeth Grass, Megan L Neely, Simon G Gregory, Keith A A Fox, Paul W Armstrong, Harvey D White, E Magnus Ohman, Matthew T Roe, Svati H Shah, Mark Y Chan
BACKGROUND AND AIMS: Although circulating microRNA (miRNAs) have emerged as biomarkers predicting mortality in acute coronary syndrome (ACS), more data are needed to understand these mechanisms. Mapping miRNAs to high-risk traits may identify miRNAs involved in pathways conferring risk for poor outcome in ACS. We aim to investigate the relationship between circulating miRNAs and high-risk traits in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: Whole-genome miRNA sequencing was performed on RNA extracted from whole blood of 199 patients with NSTE-ACS...
March 30, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28385392/metabolically-healthy-obesity-and-the-risk-for-subclinical-atherosclerosis
#13
Tae Jun Kim, Hee-Young Shin, Yoosoo Chang, Mira Kang, Jaehwan Jee, Yoon-Ho Choi, Hyeon Seon Ahn, Soo Hyun Ahn, Hee Jung Son, Seungho Ryu
BACKGROUND AND AIMS: Although obesity and metabolic abnormalities are known risk factors for cardiovascular disease, the risk of cardiovascular disease among obese individuals without obesity-related metabolic abnormalities, referred to as metabolically healthy obese (MHO), remains unclear. We examined the association between body mass index categories and the development of subclinical carotid atherosclerosis in a cohort of metabolically healthy individuals. METHODS: We conducted a cohort study of 6453 men without subclinical carotid atherosclerosis or metabolic abnormalities at baseline, who underwent repeated health check-up examinations that included carotid ultrasound...
March 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28365003/carotid-intima-media-thickness-is-associated-with-media-rather-than-intima-thickness
#14
LETTER
Amanda V Sardeli, Arthur F Gáspari, Guilherme de Rossi, Giovana V de Souza, Thiago M F de Souza, Cláudia R Cavaglieri, José R Matos-Souza, Wilson Nadruz, Mara P T Chacon-Mikahil
No abstract text is available yet for this article.
March 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28410749/efficacy-and-safety-of-k-877-a-novel-selective-peroxisome-proliferator-activated-receptor-%C3%AE-modulator-spparm%C3%AE-in-combination-with-statin-treatment-two-randomised-double-blind-placebo-controlled-clinical-trials-in-patients-with-dyslipidaemia
#15
Hidenori Arai, Shizuya Yamashita, Koutaro Yokote, Eiichi Araki, Hideki Suganami, Shun Ishibashi
BACKGROUND AND AIMS: Substantial residual cardiovascular risks remain despite intensive statin treatment. Residual risks with high triglyceride and low high-density lipoprotein cholesterol are not the primary targets of statins. K-877 (pemafibrate) demonstrated robust efficacy on triglycerides and high-density lipoprotein cholesterol and a good safety profile as a monotherapy. The aim of these studies was to evaluate the efficacy and safety of K-877 add-on therapy to treat residual hypertriglyceridaemia during statin treatment...
March 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28372787/considerations-about-prevalence-of-hypertension-and-hypertension-phenotypes-by-age-and-gender-among-schoolchildren-in-greece-the-healthy-growth-study
#16
LETTER
Pier Paolo Bassareo, Giovanni Mercuro
No abstract text is available yet for this article.
March 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28372786/clinical-application-of-effective-atomic-number-for-classifying-non-calcified-coronary-plaques-by-dual-energy-computed-tomography
#17
Shun Nakajima, Hiroyuki Ito, Tetsuya Mitsuhashi, Yutaka Kubo, Kazuhiro Matsui, Isao Tanaka, Rika Fukui, Hisako Omori, Takashi Nakaoka, Hiroshi Sakura, Eiko Ueno, Haruhiko Machida
BACKGROUND AND AIMS: Coronary computed tomography (CT) angiography allows non-invasive classification of non-calcified coronary plaques (NCCPs) based on Hounsfield unit (HU) values. This methodology, however, is somewhat limited for reliable classification of NCCPs. Therefore, we evaluated the effective atomic number (EAN) for classifying NCCPs by single-source dual-energy CT with fast tube voltage switching (SSDECT). METHODS: We prospectively enrolled 18 patients undergoing both SSDECT and intravascular ultrasonography (IVUS)...
March 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28363516/vascular-disease-in-cocaine-addiction
#18
REVIEW
Keren Bachi, Venkatesh Mani, Devi Jeyachandran, Zahi A Fayad, Rita Z Goldstein, Nelly Alia-Klein
Cocaine, a powerful vasoconstrictor, induces immune responses including cytokine elevations. Chronic cocaine use is associated with functional brain impairments potentially mediated by vascular pathology. Although the Crack-Cocaine epidemic has declined, its vascular consequences are increasingly becoming evident among individuals with cocaine use disorder of that period, now aging. Paradoxically, during the period when prevention efforts could make a difference, this population receives psychosocial treatment at best...
March 14, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28298251/impact-of-psychological-health-on-peripheral-endothelial-function-and-the-hpa-axis-activity-in-healthy-adolescents
#19
Yun Chen, Walter Osika, Frida Dangardt, Peter Friberg
BACKGROUND AND AIMS: The development of adolescence psychological health over a 3-year period and its relationship to peripheral endothelial function and the hypothalamic-pituitary-adrenal (HPA)-axis activity were examined in a cohort of healthy adolescents in a longitudinal study. METHODS: A total of 162 adolescents (94 females) participated in both baseline (mean age 14.5 ± 1 years) and three-year follow-up studies. Psychological health was evaluated by self-report using the Beck Youth Inventories of Emotional and Social Impairment and the psychosomatic problem scale...
March 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28347473/a-systematic-review-investigating-the-association-of-micrornas-with-human-abdominal-aortic-aneurysms
#20
Vikram Iyer, Sophie Rowbotham, Erik Biros, John Bingley, Jonathan Golledge
BACKGROUND AND AIMS: There is increasing interest in identifying novel methods for abdominal aortic aneurysm (AAA) diagnosis. Non-coding RNA molecules such as microRNAs (miRNAs) are stable within the circulation and may serve as biomarkers for AAA. This systematic review aimed to identify miRNAs associated with a diagnosis of human AAA based on currently published original research. METHODS: A systematic search of the MEDLINE and EMBASE databases identified studies assessing miRNA expression in abdominal aortic tissue or circulating blood from human AAA cases compared to non-aneurysmal controls...
March 8, 2017: Atherosclerosis
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