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Atherosclerosis

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https://www.readbyqxmd.com/read/28214425/favorable-cardiovascular-risk-factor-profile-is-associated-with-lower-healthcare-expenditure-and-resource-utilization-among-adults-with-diabetes-mellitus-free-of-established-cardiovascular-disease-2012-medical-expenditure-panel-survey-meps
#1
David I Feldman, Javier Valero-Elizondo, Joseph A Salami, Jamal S Rana, Oluseye Ogunmoroti, Chukwuemeka U Osondu, Erica S Spatz, Salim S Virani, Ron Blankstein, Michael J Blaha, Emir Veledar, Khurram Nasir
BACKGROUND AND AIMS: Given the prevalence and economic burden of diabetes mellitus (DM), we studied the impact of a favorable cardiovascular risk factor (CRF) profile on healthcare expenditures and resource utilization among individuals without cardiovascular disease (CVD), by DM status. METHODS: 25,317 participants were categorized into 3 mutually-exclusive strata: "Poor", "Average" and "Optimal" CRF profiles (≥4, 2-3, 0-1 CRF, respectively). Two-part econometric models were utilized to study cost data...
February 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28214424/association-between-plaque-characteristics-and-the-amount-of-debris-captured-by-a-filter-type-distal-protection-device-in-patients-with-acute-coronary-syndrome
#2
Katsuhide Kitagawa, Tetsuya Amano, Tadayuki Uetani, Hideki Ishii, Takahiro Okumura, Susumu Suzuki, Hiroaki Takashima, Akiyoshi Kurita, Hirohiko Ando, Tatsuaki Matsubara, Toyoaki Murohara
BACKGROUND AND AIMS: Disruption of atherosclerotic plaque and distal embolism often cause peri-procedural myocardial injury during percutaneous coronary intervention (PCI). In the present study, we evaluate the association between the characteristics of the target lesion and the amount of debris captured by the filter-type distal protection device. METHODS: We enrolled 120 consecutive patients with acute coronary syndrome, who underwent coronary stent implantation with a filter-type distal protection device after integrated backscatter intravascular ultrasound (IB-IVUS) analysis...
February 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28213199/cardiovascular-risk-in-different-obesity-phenotypes-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#3
Bita Mirzaei, Hengameh Abdi, Sara Serahati, Maryam Barzin, Mahtab Niroomand, Fereidoun Azizi, Farhad Hosseinpanah
BACKGROUND AND AIMS: Considering the inconsistent data available on cardiovascular (CV) risk of different obesity phenotypes, the aim of this study was to investigate the development of cardiovascular disease (CVD) in different obesity phenotypes over a median follow-up of 12 years. METHODS: In this large population-based cohort, 7842 participants (44.8% men), aged ≥ 30 years, were enrolled. Participants were divided into six phenotypes based on body mass index and metabolic status...
February 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28192729/absence-of-association-between-gallstone-and-coronary-artery-calcification
#4
Chang Hee Kwon, Jung Gyu Kang, Hyun Jong Lee, Nan Hee Kim, Joo-Wook Sung, EunSun Cheong, Ki-Chul Sung
BACKGROUND AND AIMS: Gallstone has been suggested to be associated with cardiovascular disease (CVD). Coronary artery calcification (CAC) is an excellent value to predict future CVD. The aim of this study was to evaluate the association between gallstone and CAC. METHODS: Data were analyzed from an occupational cohort of 46,893 subjects (37,557 men and 9336 women) between 2011 and 2014. Participants with cancer or CVD histories or missing data at baseline were excluded from the study...
February 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28189039/low-dose-prednisolone-and-insulin-sensitivity-differentially-affect-arterial-stiffness-and-endothelial-function-an-open-interventional-and-cross-sectional-study
#5
Carolyn J Petersons, Brenda L Mangelsdorf, Anne Poljak, Malcolm D Smith, Jerry R Greenfield, Campbell H Thompson, Morton G Burt
BACKGROUND AND AIMS: Glucocorticoids could impair vascular function directly, or indirectly by reducing insulin sensitivity. The aim of this study was to determine the direct and indirect effects of acute and chronic low dose prednisolone on arterial stiffness and endothelial function. METHODS: Twelve subjects with inflammatory arthritis, who had not taken oral glucocorticoids for ≥6 months, and 12 subjects with inflammatory arthritis, taking chronic (>6 months) low dose (6...
January 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28162236/sr-bi-as-target-in-atherosclerosis-and-cardiovascular-disease-a-comprehensive-appraisal-of-the-cellular-functions-of-sr-bi-in-physiology-and-disease
#6
REVIEW
Menno Hoekstra
High-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein species due to its role in reverse cholesterol transport. HDL delivers cholesterol esters to the liver through selective uptake by scavenger receptor class B type I (SR-BI). In line with the protective role for HDL in the context of cardiovascular disease, studies in mice and recently also in humans have shown that a disruption of normal SR-BI function predisposes subjects to the development of atherosclerotic lesions and cardiovascular disease...
January 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28216252/calcification-of-the-splenic-iliac-and-breast-arteries-and-risk-of-all-cause-and-cardiovascular-mortality
#7
Eva J E Hendriks, Joline W J Beulens, Pim A de Jong, Yvonne T van der Schouw, Wei-Ning Sun, C Michael Wright, Michael H Criqui, Matthew A Allison, Joachim H Ix
BACKGROUND AND AIMS: CVD risks associated with coronary artery calcification (CAC) and aortic calcification (AC) are well known, but less is known about other calcified arteries. We aimed to assess the associations of arterial calcification in the breast, splenic, and internal and external iliac arteries with CVD risk factors and mortality. METHODS: We conducted a case-cohort study nested in a cohort of 5196 individuals who self-referred or were referred by a health care provider for whole body computed tomography (CT), including a random subcohort (n = 395) and total and CVD mortality cases (n = 298 and n = 90), who died during a median follow-up of 9...
January 30, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28196336/regression-of-atherosclerosis-with-apple-procyanidins-by-activating-the-atp-binding-cassette-subfamily-a-member-1-in-a-rabbit-model
#8
Liang Wang, Toshio Fumoto, Saeko Masumoto, Toshihiko Shoji, Tomisato Miura, Masato Naraoka, Naoya Matsuda, Tadaatsu Imaizumi, Hiroki Ohkuma
BACKGROUND AND AIMS: Apple polyphenol contains abundant procyanidins, which have been associated with an anti-atherosclerosis and cholesterol-lowering effect. The aim of this study was to investigate whether apple procyanidins (APCs) feature therapeutic efficacy in terms of regressing atherosclerosis and whether this efficacy is due to mechanisms other than a cholesterol-lowering effect. METHODS: After eight weeks on an atherogenic diet, rabbits were given a normal diet for another eight weeks to normalize the increased serum lipids level...
January 27, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28189040/an-anti-%C3%AE-v%C3%AE-3-antibody-inhibits-coronary-artery-atherosclerosis-in-diabetic-pigs
#9
L A Maile, W H Busby, G Xi, K P Gollahan, W Flowers, N Gafbacik, S Gafbacik, K Stewart, E P Merricks, T C Nichols, D A Bellinger, D R Clemmons
BACKGROUND AND AIMS: Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (VSMC) to secrete ligands that bind to the αVβ3 integrin, a receptor that regulates VSMC proliferation and migration. This study determined whether an antibody that had previously been shown to block αVβ3 activation and to inhibit VSMC proliferation and migration in vitro, inhibited the development of atherosclerosis in diabetic pigs. METHODS: Twenty diabetic pigs were maintained on a high fat diet for 22 weeks...
January 27, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28159319/invasive-or-not-invasive-is-the-question
#10
EDITORIAL
Jacques D Barth
No abstract text is available yet for this article.
January 26, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28167353/genetic-risk-analysis-of-coronary-artery-disease-in-pakistani-subjects-using-a-genetic-risk-score-of-21-variants
#11
Saleem Ullah Shahid, Shabana, Jackie A Cooper, Katherine E Beaney, Kawah Li, Abdul Rehman, Steve E Humphries
BACKGROUND AND AIMS: Conventional coronary artery disease (CAD) risk factors like age, gender, blood lipids, hypertension and smoking have been the basis of CAD risk prediction algorithms, but provide only modest discrimination. Genetic risk score (GRS) may provide improved discrimination over and above conventional risk factors. Here we analyzed the genetic risk of CAD in subjects from Pakistan, using a GRS of 21 variants in 18 genes and examined whether the GRS is associated with blood lipid levels...
January 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28122675/beware-of-calcium-but-respect-the-narrowing
#12
EDITORIAL
Sorin J Brener
No abstract text is available yet for this article.
January 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28167355/development-of-a-new-bioactivatable-fluorescent-probe-for-quantification-of-apolipoprotein-a-i-proteolytic-degradation-in%C3%A2-vitro-and-in%C3%A2-vivo
#13
Foued Maafi, Baoqiang Li, Catherine Gebhard, Mathieu R Brodeur, Walid Nachar, Louis Villeneuve, Frédéric Lesage, David Rhainds, Eric Rhéaume, Jean-Claude Tardif
BACKGROUND AND AIMS: The potential benefits of high-density lipoproteins (HDL) against atherosclerosis are attributed to its major protein component, apolipoprotein A-I (apoA-I). Most of the apoA-I in the vascular wall appears to be in its lipid-poor form. The latter, however, is subjected to degradation by proteases localized in atherosclerotic plaques, which, in turn, has been shown to negatively impact its atheroprotective functions. Here, we report the development and in vivo use of a bioactivatable near-infrared full-length apoA-I-Cy5...
January 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28161097/prevalence-of-hypertension-and-hypertension-phenotypes-by-age-and-gender-among-schoolchildren-in-greece-the-healthy-growth-study
#14
Kalliopi Karatzi, Athanase D Protogerou, George Moschonis, Christiana Tsirimiagou, Odysseas Androutsos, George P Chrousos, Christos Lionis, Yannis Manios
BACKGROUND AND AIMS: Childhood hypertension is a constantly increasing health problem. Data regarding its prevalence and particularly the prevalence of its phenotypes in the Greek population are limited; therefore, the aim of the study was to determine them in a large sample of Greek children. METHODS: A sample of 2655 schoolchildren (9-13 years) participated in the Healthy Growth Study, i.e. a cross-sectional epidemiologic study conducted in 77 primary schools in four large regions in Greece...
January 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28159321/calcification-of-the-aortic-wall-indicates-risk-but-not-beyond-current-clinically-used-risk-factors-assessment
#15
EDITORIAL
Raimund Erbel, Sofia Churzidse
No abstract text is available yet for this article.
January 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28159320/reply-to-endothelial-progenitor-cell-release-is-usually-considered-a-beneficial-effect-problems-in-interpreting-the-acute-effects-of-e-cigarette-use
#16
LETTER
Lukasz Antoniewicz, Anna Kiessling, Fariborz Mobarrez, Magnus Lundbäck
No abstract text is available yet for this article.
January 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28182996/vital-roles-of-age-and-metabolic-syndrome-associated-risk-factors-in-sex-specific-arterial-stiffness-across-nearly-lifelong-ages-possible-implication-of-menopause-and-andropause
#17
Sung-Sheng Tsai, Yu-Sheng Lin, Jaw-Shan Hwang, Pao-Hsien Chu
BACKGROUND AND AIMS: Postmenopausal status is correlated with increased metabolic syndrome (MetS) and cardiovascular risks. However, the vital roles of age and MetS-associated risk factors in sex-specific arterial stiffness remain unclear. METHODS: In this population-based cross-sectional study of the general population, we enrolled in our Health Examination Program 9812 adult participants who were measured for brachial-ankle pulse wave velocity (baPWV) to assess arterial stiffness...
January 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28131045/inflammatory-gene-expression-in-whole-blood-cells-after-epa-vs-dha-supplementation-results-from-the-compared-study
#18
Cécile Vors, Janie Allaire, Johanne Marin, Marie-Claude Lépine, Amélie Charest, André Tchernof, Patrick Couture, Benoît Lamarche
BACKGROUND AND AIMS: Whether EPA and DHA exert similar anti-inflammatory effects through modulation of gene expression in immune cells remains unclear. The aim of the study was to compare the impact of EPA and DHA supplementation on inflammatory gene expression in subjects at risk for cardiometabolic diseases. METHODS: In this randomized double-blind crossover trial, 154 men and women with abdominal obesity and low-grade inflammation were subjected to three 10-wk supplementation phases: 1) EPA (2...
January 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28167354/coronary-atherosclerosis-and-dilation-in-hyper-ige-syndrome-patients-depiction-by-magnetic-resonance-vessel-wall-imaging-and-pathological-correlation
#19
Khaled Z Abd-Elmoniem, Nadine Ramos, Saami K Yazdani, Ahmed M Ghanem, Steven M Holland, Alexandra F Freeman, Ahmed M Gharib
BACKGROUND AND AIMS: Autosomal dominant hyper-IgE (AD-HIES) is a primary immunodeficiency caused by mutations in STAT3. Elevated levels of IgE, an ineffective immune response, connective tissue abnormalities, and coronary arterial dilation and tortuosity characterize AD-HIES. To date, coronary artery evaluation in AD-HIES patients has been limited to lumenography measurements. Direct in vivo coronary vessel wall (VW) imaging may allow for better interrogation of coronary vessel abnormalities...
January 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28129889/sarcopenia-but-not-excess-weight-or-increased-caloric-intake-is-associated-with-coronary-subclinical-atherosclerosis-in-the-very-elderly
#20
Alessandra M Campos, Filipe A Moura, Simone N Santos, Wladimir M Freitas, Andrei C Sposito
BACKGROUND AND AIMS: Excess weight is a widespread condition related to increased risk of coronary heart disease (CHD). Sarcopenia is a catabolic pathway common of the aging process and also associated with CHD. In the elderly, both changes occur concurrently and it remains unclear the relative contribution on CHD risk. We aimed to investigate whether sarcopenia, excess weight, or both are associated with subclinical atherosclerosis and/or endothelial dysfunction in very elderly individuals...
January 18, 2017: Atherosclerosis
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