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Atherosclerosis

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https://www.readbyqxmd.com/read/30340109/pregnancy-associated-plasma-protein-a-in-atherosclerosis-molecular-marker-mechanistic-insight-and-therapeutic-target
#1
REVIEW
Xiao-Hua Yu, Lin-Hao He, Jia-Hui Gao, Da-Wei Zhang, Xi-Long Zheng, Chao-Ke Tang
Pregnancy-associated plasma protein-A (PAPP-A), a member of the metzincin metalloproteinase superfamily, can enhance local insulin-like growth factor (IGF) bioavailability through proteolytic cleavage of three IGF binding proteins. In patients with coronary atherosclerosis disease (CAD), elevated PAPP-A levels are significantly associated with a higher risk of cardiovascular events. Accumulating evidence indicates that this protease exerts a proatherogenic effect by altering a variety of pathological processes involved in atherosclerosis, including lipid accumulation, vascular inflammation, endothelial dysfunction, vascular smooth muscle cell proliferation and migration, plaque stability, and thrombus formation...
October 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30340764/potential-epigenetic-therapeutics-for-atherosclerosis-treatment
#2
REVIEW
Ioana Nicorescu, Geesje M Dallinga, Menno P J de Winther, Erik S G Stroes, Mahnoush Bahjat
Notwithstanding the intense efforts into the understanding and prevention of cardiovascular disease (CVD), its complex pathology remains the leading cause of mortality worldwide. The pivotal role of epigenetic changes in the control of gene expression has been profiled in several diseases, such as cancer and inflammatory disorders. In the last decade, increasing evidence has also linked aberrant epigenetic modulation as a contributor to CVD development. Differential profiles of DNA methylation, histone methylation and acetylation have consistently been observed in tissues and cells (comprising the aortic lesions, vascular endothelium and monocytes) from patients with CVD...
October 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30305237/corrigendum-to-proteoglycan-4-regulates-macrophage-function-without-altering-atherosclerotic-lesion-formation-in-a-murine-bone-marrow-specific-deletion-model-atherosclerosis-274-july-2018-120-127
#3
Joya E Nahon, Menno Hoekstra, Stefan R Havik, Peter J Van Santbrink, Geesje M Dallinga-Thie, Jan-Albert Kuivenhoven, Janine J Geerling, Miranda Van Eck
No abstract text is available yet for this article.
October 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30327129/thoracic-adipose-tissue-density-as-a-novel-marker-of-increased-cardiovascular-risk
#4
EDITORIAL
Amir A Mahabadi, Tienush Rassaf
No abstract text is available yet for this article.
October 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30326405/hyperuricemia-and-endothelial-function-from-molecular-background-to-clinical-perspectives
#5
REVIEW
Tatsuya Maruhashi, Ichiro Hisatome, Yasuki Kihara, Yukihito Higashi
Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans. In the process of purine metabolism, reactive oxygen species, including superoxide, are generated concomitantly with uric acid production, which may deteriorate endothelial function through the reaction of superoxide with nitric oxide (NO), leading to decreased NO bioavailability and increased production of peroxynitrite, a reactive oxidant. Therefore, xanthine oxidase may be a therapeutic target in the treatment of endothelial dysfunction...
October 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30301567/corrigendum-to-vascular-brain-derived-neurotrophic-factor-pathway-in-rats-with-adjuvant-induced-arthritis-effect-of-anti-rheumatic-drugs-atherosclerosis-274-july-2018-77-85
#6
Martin Pedard, Aurore Quirie, Perle Totoson, Frank Verhoeven, Philippe Garnier, Anne Tessier, Ce'line Demougeot, Christine Marie
No abstract text is available yet for this article.
October 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30340108/hdl-is-essential-for-atherosclerotic-lesion-regression-in-apoe-knockout-mice-by-bone-marrow-apoe-reconstitution
#7
Ronald J van der Sluis, Robin A F Verwilligen, Zsuzsanna Lendvai, Robbert Wever, Menno Hoekstra, Miranda Van Eck
BACKGROUND AND AIMS: Although studies in mice have suggested that lesion regression is feasible, the underlying mechanisms remain largely unknown. Here we determined the impact of high-density lipoprotein (HDL) on atherosclerosis regression outcome. METHODS: Atherosclerotic lesion dynamics were studied upon bone marrow transplantation-mediated re-introduction of apolipoprotein E (Apoe) in Apoe knockout mice. Probucol was used to pharmacologically deplete HDL. RESULTS: Restoration of Apoe function was associated with an initial growth of atherosclerotic lesions and parallel decrease in lesional macrophage foam cell content (47 ± 4% at 4 weeks versus 72 ± 2% at baseline: p < 0...
October 4, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30312930/the-prognostic-value-of-interleukin-6-in-multiple-chronic-diseases-and-all-cause-death-the-multi-ethnic-study-of-atherosclerosis-mesa
#8
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30336307/next-generation-microrna-sequencing-to-identify-coronary-artery-disease-patients-at-risk-of-recurrent-myocardial-infarction
#9
Sri H Kanuri, Joseph Ipe, Kameel Kassab, Hongyu Gao, Yunlong Liu, Todd C Skaar, Rolf P Kreutz
BACKGROUND AND AIMS: Variation in micro-RNA (miRNA) levels in blood has been associated with alterations of physiological functions of the cardiovascular system. Circulating miRNA have the potential to become reliable biomarkers for risk stratification and early detection of cardiovascular events. Recurrent thrombotic events in patients with established coronary artery disease (CAD) demonstrate the need for personalized approaches to secondary prevention, especially in light of recent novel treatment approaches...
October 3, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30312929/detecting-familial-hypercholesterolemia-earlier-in-life-by-actively-searching-for-affected-children-the-decopin-project
#10
Daiana Ibarretxe, Cèlia Rodríguez-Borjabad, Albert Feliu, José Ángel Bilbao, Lluís Masana, Núria Plana
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is underdiagnosed in children. We assessed a combination of two screening methods. The first method was to detect hypercholesteraemic children and then study the parents (Ch-P pathway), and the second one was to study the offspring of FH-affected parents (P-Ch pathway). METHODS: In the Ch-P path, primary care paediatricians were asked to include lipid profiling or, at least, total cholesterol (TC) and then lipid profiling if TC was higher than 5...
October 1, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30316538/long-intergenic-noncoding-rnas-in-cardiovascular-diseases-challenges-and-strategies-for-physiological-studies-and-translation
#11
REVIEW
Xuan Zhang, Daniel Y Li, Muredach P Reilly
Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as important mediators of many biological processes relevant to human pathophysiologies, including cardiovascular diseases. In vitro studies have provided important knowledge of cellular functions and mechanisms for an increasing number of lincRNAs. Dysregulated lncRNAs have been associated with cell fate programming and development, vascular diseases, atherosclerosis, dyslipidemia and metabolic syndrome, and cardiac pathological hypertrophy...
September 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30340110/the-atheroprotective-role-of-lipoxin-a-4-prevents-oxldl-induced-apoptotic-signaling-in-macrophages-via-jnk-pathway
#12
Jingting Mai, Wenhao Liu, YongBiao Fang, Shujuan Zhang, Qiong Qiu, Ying Yang, Xiaoqiao Wang, TuCheng Huang, HaiFeng Zhang, Yong Xie, Maohuan Lin, YangXin Chen, Jingfeng Wang
BACKGROUND AND AIMS: We examined whether the inflammation resolution mediator lipoxin A4 (LXA4 ) inhibits foam cell formation and oxidized low-density lipoprotein (oxLDL)-induced apoptotic signaling in macrophages and the role of circulating/local LXA4 biosynthesis in atherogenesis. METHODS: LXA4 levels were measured by enzyme-linked immunosorbent assay. Dil-oxLDL and Dil-acLDL binding to and uptake by macrophages were evaluated by flow cytometry. Apoptosis was evaluated by TUNEL and Annexin V/PI assays...
September 28, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30300788/ctrp5-promotes-transcytosis-and-oxidative-modification-of-low-density-lipoprotein-and-the-development-of-atherosclerosis
#13
Chang Li, Jia Wei Chen, Zhu Hui Liu, Ying Shen, Feng Hua Ding, Gang Gu, Jun Liu, Jia Pei Qiu, Jie Gao, Rui Yan Zhang, Wei Feng Shen, Xiao Qun Wang, Lin Lu
BACKGROUND AND AIMS: Increased transcytosis of low-density lipoprotein (LDL) across the endothelium and oxidation of LDL deposited within the subendothelial space are crucial early events in atherogenesis. C1q/TNF-related protein (CTRP) 5 is a novel secreted glycoprotein and its biological functions are largely undefined. METHODS: Expression of CTRP5 was analyzed in sera and atherosclerotic plaques of patients with coronary artery disease (CAD). The role of CTRP5 in atherogenesis was investigated in vitro and in vivo...
September 28, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30296724/sex-specific-trajectories-of-measures-of-cardiovascular-health-during-childhood-and-adolescence-a-prospective-cohort-study
#14
Linda M O'Keeffe, Andrew J Simpkin, Kate Tilling, Emma L Anderson, Alun D Hughes, Debbie A Lawlor, Abigail Fraser, Laura D Howe
BACKGROUND AND AIMS: Sex differences in measures of cardiovascular health in adults are well documented. However, the sex-specific aetiology of cardiovascular health across childhood and adolescence is poorly understood. METHODS: We examined sex differences in trajectories of 11 measures of cardiovascular health from birth to 18 years, in a contemporary birth cohort study in England (N participants per outcomes: 662-13,985, N repeated measures per outcome: 1,831-112,768)...
September 27, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30287049/reply-to-replicability-of-exercise-programs-following-bariatric-surgery
#15
LETTER
Charlotte Røn Stolberg, Lene Hymøller Mundbjerg, Peter Funch-Jensen, Bibi Gram, Else-Marie Bladbjerg, Claus Bogh Juhl
No abstract text is available yet for this article.
September 27, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30290963/epigenetic-processing-in-cardiometabolic-disease
#16
REVIEW
Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, Francesco Paneni
Albeit a consistent body of evidence supports the notion that genes influence cardiometabolic features and outcomes, the "non-genetic regulation" of this process is gaining increasing attention. Plastic chemical changes of DNA/histone complexes - known as epigenetic changes - critically determine gene activity by rapidly modifying chromatin accessibility to transcription factors. In this review, we describe the emerging role of chromatin modifications as fine tuners of gene transcription in adipogenesis, insulin resistance, macrophage polarization, immuno-metabolism, endothelial dysfunction and metabolic cardiomyopathy...
September 26, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30278356/cetp-inhibition-statins-and-diabetes
#17
REVIEW
Philip J Barter, Blake J Cochran, Kerry-Anne Rye
Type 2 diabetes is a causal risk factor for the development of atherosclerotic cardiovascular disease (ASCVD). While treatment with a statin reduces the risk of having an ASCVD event in all people, including those with type-2 diabetes, statin treatment also increases the likelihood of new onset diabetes when given to those with risk factors for developing diabetes. Treatment with the cholesteryl ester transfer protein (CETP) inhibitor, anacetrapib, reduces the risk of having a coronary event over and above that achieved with a statin...
September 26, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30278990/hypercholesterolemia-impairs-megakaryopoiesis-and-platelet-production-in-scavenger-receptor-bi-knockout-mice
#18
Amber B Ouweneel, Menno Hoekstra, Ezra J van der Wel, Frank H Schaftenaar, Olga S C Snip, Jasmin Hassan, Suzanne J A Korporaal, Miranda Van Eck
BACKGROUND AND AIMS: Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency may also influence platelet production at the level of its precursor cell in the bone marrow, the megakaryocyte. METHODS: In this study, we compared megakaryopoiesis and platelet production in SR-BI knockout and wild-type mice...
September 22, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30278358/cold-shock-y-box-binding-protein-1-acetylation-status-in-monocytes-is-associated-with-systemic-inflammation-and-vascular-damage
#19
Lara Ewert, Anja Fischer, Sabine Brandt, Florian G Scurt, Lars Philipsen, Andreas J Müller, Matthias Girndt, Ana C Zenclussen, Jonathan A Lindquist, Xenia Gorny, Peter R Mertens
BACKGROUND AND AIMS: In dialysis patients, vascular morbidities are highly prevalent and linked to leukocyte extravasation, especially of polarized monocytes. Experimental data demonstrate that phenotypic changes in monocytes require Y-box binding protein-1 (YB-1) upregulation. METHODS: We determined YB-1 expression in circulating and vessel-invading monocytes from healthy controls and dialysis patients to correlate results with intima plaque formation and systemic inflammation...
September 22, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30253877/erratum-to-ankle-brachial-index-and-cognitive-function-among-hispanics-latinos-results-from-the-hispanic-community-health-study-study-of-latinos-atherosclerosis-271-april-2018-61-69
#20
Wassim Tarraf, Michael H Criqui, Matthew A Allison, Clinton B Wright, Myriam Fornage, Martha Daviglus, Robert C Kaplan, Sonia Davis, Alan S Conceicao, Hector M González
No abstract text is available yet for this article.
September 22, 2018: Atherosclerosis
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