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Michael France, Alan Rees, Dev Datta, Gilbert Thompson, Nigel Capps, Gordon Ferns, Uma Ramaswami, Mary Seed, Dermot Neely, Robert Cramb, Carol Shoulders, Mahmoud Barbir, Alison Pottle, Ruth Eatough, Steven Martin, Graham Bayly, Bill Simpson, Julian Halcox, Ray Edwards, Linda Main, Jules Payne, Handrean Soran
This consensus statement addresses the current three main modalities of treatment of homozygous familial hypercholesterolaemia (HoFH): pharmacotherapy, lipoprotein (Lp) apheresis and liver transplantation. HoFH may cause very premature atheromatous arterial disease and death, despite treatment with Lp apheresis combined with statin, ezetimibe and bile acid sequestrants. Two new classes of drug, effective in lowering cholesterol in HoFH, are now licensed in the United Kingdom. Lomitapide is restricted to use in HoFH but, may cause fatty liver and is very expensive...
November 5, 2016: Atherosclerosis
Roberto Scicali, Philippe Giral, Antonio Gallo, Antonino Di Pino, Agata Maria Rabuazzo, Francesco Purrello, Philippe Cluzel, Alban Redheuil, Eric Bruckert, David Rosenbaum
BACKGROUND AND AIMS: Prediabetes is associated with an increased risk of developing diabetes and cardiovascular disease. Our objective was to examine the cardiovascular (CV) risk profile of non-diabetic patients with and without prediabetes according to HbA1c, using macroangiopathic imaging biomarkers. METHODS: Our population consisted of 272 non diabetic patients aged between 40 and 70 years, with a normal fasting plasma glucose (FPG <5.6 mmol/L) and at least 1 CV risk factor...
November 4, 2016: Atherosclerosis
Ken Harada, Toyoaki Murohara
No abstract text is available yet for this article.
November 3, 2016: Atherosclerosis
Anxin Wang, Ruixuan Jiang, Zhaoping Su, Jiaokun Jia, Ning Zhang, Jianwei Wu, Shengyun Chen, Xingquan Zhao
BACKGROUND AND AIMS: Given the recognized links between atherosclerosis and cognitive impairment, the aim of this study was to examine the association between the ankle-brachial index (ABI) and cognitive impairment in a cross-sectional setting of a Chinese population. METHODS: Participants (n = 3,048, aged ≥40 years, 1727 men and 1321 women) were recruited from the ongoing community-based Asymptomatic Polyvascular Abnormalities Community Study. ABI was measured and a low ABI was defined as <0...
November 3, 2016: Atherosclerosis
Rine Nakanishi, Indre Ceponiene, Kazuhiro Osawa, Yanting Luo, Mitsuru Kanisawa, Nichelle Megowan, Negin Nezarat, Sina Rahmani, Alexander Broersen, Pieter H Kitslaar, Christopher Dailing, Matthew J Budoff
BACKGROUND AND AIMS: We aimed at investigating whether diabetes is associated with progression in coronary plaque components. METHODS: We identified 142 study subjects undergoing serial coronary computed tomography angiography. The resulting propensity score was applied 1:1 to match diabetic patients to non-diabetic patients for clinical risk factors, prior coronary stenting, coronary artery calcium (CAC) score and the serial scan interval, resulting in the 71 diabetes and 71 non-diabetes patients...
November 3, 2016: Atherosclerosis
Miguel Hueso, Laura De Ramon, Estanislao Navarro, Elia Ripoll, Josep M Cruzado, Josep M Grinyo, Joan Torras
BACKGROUND AND AIMS: CD40/CD40L signaling exerts a critical role in the development of atherosclerosis, and microRNAs (miRNAs) are key regulators in vascular inflammation and plaque formation. In this work, we investigated mRNA/miRNA expression during progression of atherosclerotic lesions through CD40 silencing. METHODS: We silenced CD40 with a specific siRNA in ApoE(-/-) mice and compared expression of mRNA/miRNA in ascending aorta with scrambled treated mice...
November 2, 2016: Atherosclerosis
Antonino Tuttolomondo, Alessandra Casuccio, Vittoriano Della Corte, Carlo Maida, Rosaria Pecoraro, Domenico Di Raimondo, Valerio Vassallo, Irene Simonetta, Valentina Arnao, Antonio Pinto
BACKGROUND AND AIMS: Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endothelial dysfunction indexes in patients with acute ischemic stroke and the relationship between endothelial dysfunction indexes and arterial stiffness markers and stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification...
October 29, 2016: Atherosclerosis
Wessel W Fuijkschot, Martine C Morrison, Rianne van der Linden, Paul A J Krijnen, Ilse P A Zethof, Lars F H Theyse, Robert Kleemann, Hans W M Niessen, Yvo M Smulders
BACKGROUND AND AIMS: Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement. The acuteness of this increased risk suggests abrupt enhancement in plaque vulnerability, which may be related to intra-plaque inflammation, thinner fibrous cap and/or necrotic core expansion. We hypothesized that acute systemic inflammation following major orthopedic surgery induces such changes...
October 28, 2016: Atherosclerosis
Johanna M Gostner, Dietmar Fuchs
No abstract text is available yet for this article.
October 27, 2016: Atherosclerosis
Hans J Trampisch, Henrik Rudolf, Stefan Lange
No abstract text is available yet for this article.
October 27, 2016: Atherosclerosis
J David Spence
No abstract text is available yet for this article.
October 27, 2016: Atherosclerosis
Alejandro Gugliucci
No abstract text is available yet for this article.
October 26, 2016: Atherosclerosis
Vincenzo Marottoli, Antonio Ciampa, Luig Iannaccone, Vincenzo Brancaccio, Paul R J Ames
No abstract text is available yet for this article.
October 26, 2016: Atherosclerosis
Christian Heiss
No abstract text is available yet for this article.
October 26, 2016: Atherosclerosis
Fernanda Carla Ferreira de Brito
No abstract text is available yet for this article.
October 26, 2016: Atherosclerosis
Saskia Haitjema, Steven T W van Haelst, Jean-Paul P M de Vries, Frans L Moll, Hester M den Ruijter, Gert J de Borst, Gerard Pasterkamp
BACKGROUND AND AIMS: Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis with an increasing incidence worldwide. The disease is still associated with high morbidity and mortality risks. Previous research in carotid arteries indicates that atherosclerotic plaque characteristics have stabilized over time in patients considered for surgery. It is currently unknown whether this time-dependent stabilization occurs in ilio-femoral arteries as well. Our objective was to analyze whether local ilio-femoral atherosclerotic plaque characteristics have changed over time...
October 25, 2016: Atherosclerosis
Herman J Kempen, Monica Gomaraschi, Sara Simonelli, Laura Calabresi, Matthijs Moerland, James Otvos, Elias Jeyarajah, David Kallend, Peter L J Wijngaard
BACKGROUND AND AIMS: Effects of single ascending doses of MDCO-216 on plasma lipid and lipoprotein levels were assessed in human healthy volunteers and in patients with stable coronary artery disease (CAD). METHODS: MDCO-216 was infused at a single dose of 5, 10, 20, 30 or 40 mg/kg over 2 h and blood was collected at 2, 4, 8, 24, 48, 168 and 720 h after start of infusion (ASOI). Lipoprotein lipids were assessed by FLPC and by 1H NMR. RESULTS: Plasma concentrations of free cholesterol (FC) displayed a rapid and dose-dependent rise, peaking at 8 h, but remaining above baseline until 48 h ASOI, whereas levels of esterified cholesterol (CE) increased at lower doses but not at higher doses, and even decreased below baseline at the highest dose...
October 24, 2016: Atherosclerosis
Antonino Tuttolomondo, Riccardo Di Sciacca, Domenico Di Raimondo, Antonia Serio, Gisella D'Aguanno, Antonio Pinto, Giuseppe Licata
No abstract text is available yet for this article.
October 23, 2016: Atherosclerosis
Kai-Yin Li, Lei Zheng, Qian Wang, Yan-Wei Hu
Microvesicles are formed under many circumstances, especially in atheromatous plaques. Erythrocyte-derived microvesicles (ErMVs) have been proved to promote atherosclerosis by promoting hypercoagulation, mediating inflammation and inducing cell adhesion. Several clinical studies have reported potential roles of ErMVs in cardiovascular disease diagnosis, but the current understanding of ErMVs remains insufficient. In this paper, we will review current research on the formation and degradation of ErMVs and the possible effects of ErMVs in atherosclerosis, discuss potential clinical applications in cardiovascular disease, and hope to raise awareness of the relation with atherosclerosis...
October 22, 2016: Atherosclerosis
Mike L J Jeurissen, Sofie M A Walenbergh, Tom Houben, Marion J J Gijbels, Jieyi Li, Tim Hendrikx, Yvonne Oligschlaeger, Patrick J van Gorp, Christoph J Binder, Marjo M P C Donners, Ronit Shiri-Sverdlov
BACKGROUND AND AIMS: Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifically between the oxidized type of LDL (oxLDL) and atherosclerotic lesion formation. Further observations revealed that these atherosclerotic lesions displayed enlarged, lipid-loaded lysosomes...
October 20, 2016: Atherosclerosis
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