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Christie M Ballantyne, Maciej Banach, G B John Mancini, Norman E Lepor, Jeffrey C Hanselman, Xin Zhao, Lawrence A Leiter
BACKGROUND AND AIMS: Patients with hyperlipidemia who are unable to tolerate optimal statin therapy are at increased cardiovascular risk due to ongoing elevations in low-density lipoprotein cholesterol (LDL-C). The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid when added to background lipid-modifying therapy in patients with a history of statin intolerance who require additional LDL-C lowering. METHODS: This phase 3, multicenter, randomized, double-blind, placebo-controlled study enrolled patients with a history of statin intolerance and an LDL-C ≥100 mg/dL while on stable lipid-modifying therapy...
June 12, 2018: Atherosclerosis
Lisanne L Blauw, Zhuang Li, Sander S Rensen, Jan Willem M Greve, Aswin Verhoeven, Rico J Derks, Martin Giera, Yanan Wang, Patrick C N Rensen
BACKGROUND AND AIMS: We recently showed that plasma cholesteryl ester transfer protein (CETP) is mainly derived from VSIG4-positive Kupffer cells. Activation of these cells by the bacterial endotoxin lipopolysaccharide (LPS) strongly decreases CETP expression. As Kupffer cell activation plays a detrimental role in the progression of non-alcoholic fatty liver disease (NAFLD), we aimed to study if metabolic liver inflammation is also associated with a decrease in hepatic and circulating CETP...
June 7, 2018: Atherosclerosis
Hokuto Arase, Shunsuke Yamada, Ryusuke Yotsueda, Masatomo Taniguchi, Hisako Yoshida, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono
BACKGROUND AND AIMS: The modified creatinine (Cr) index, calculated by age, sex, pre-dialysis serum Cr levels, and Kt/V for urea, reflects skeletal muscle mass in patients on hemodialysis. Whether the modified Cr index is associated with cardiovascular events and all-cause mortality remains unknown. METHODS: A total of 3027 patients registered in the Q-Cohort Study, a multicenter, prospective study of patients on hemodialysis in Japan, were analyzed. The main outcomes were cardiovascular events and all-cause mortality...
June 2, 2018: Atherosclerosis
Annette E Neele, Marion J J Gijbels, Saskia van der Velden, Marten A Hoeksema, Marieke C S Boshuizen, Koen H M Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P P A van Roomen, Annelie Shami, Johannes H M Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P J de Winther
BACKGROUND AND AIMS: Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells. We previously reported that the epigenetic enzyme Kdm6b (also known as Jmjd3) controls the pro-fibrotic transcriptional profile of peritoneal foam cells. Given the importance of these cells in atherosclerosis, we now studied the effect of myeloid Kdm6b on disease progression...
June 1, 2018: Atherosclerosis
Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Victor Aboyans, Akira Yamashina
BACKGROUND AND AIMS: The ankle-brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. METHODS: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality...
May 31, 2018: Atherosclerosis
Nieves López-Laguna, Miguel A Martínez-González, Estefania Toledo, Nancy Babio, José V Sorlí, Emilio Ros, Miguel Ángel Muñoz, Ramon Estruch, José Lapetra, Carlos Muñoz-Bravo, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, José I González, Montse Fitó, Josep Basora, Fernando Arós, Miguel Ruiz-Canela
BACKGROUND AND AIMS: The PREDIMED (PREvención con DIeta MEDiterránea) is a multicentre trial analyzed as a prospective cohort study. A total of 7122 participants (aged 55-80 years) at high risk of cardiovascular disease in the PREDIMED trial were recruited in 11 centres in Spain. The prevalence of subjects with type 2 diabetes was 50%. Our objective was to determine the contribution of lifestyle factors to the development of peripheral artery disease (PAD). METHODS: Incident clinical PAD in relation to a healthy lifestyle 5-point score defined as adherence to a Mediterranean diet (MedDiet), moderate alcohol intake, regular physical activity, normal weight (BMI<25) and non-smoking was measured...
May 31, 2018: Atherosclerosis
Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Sachiko Nishimoto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Masataka Sata
BACKGROUND AND AIMS: Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient (apoe-/- ) mice. METHODS: Eight-week-old male apoe-/- mice were fed a western-type diet (WTD) supplemented with 0...
May 31, 2018: Atherosclerosis
G B John Mancini, William E Boden, Maria M Brooks, Helen Vlachos, Bernard R Chaitman, Robert Frye, Vera Bittner, Pamela M Hartigan, Gilles R Dagenais
BACKGROUND AND AIMS: The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed. METHODS: We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T2DM randomized to optimal medical therapy [OMT], percutaneous coronary intervention [PCI] + OMT, or coronary artery bypass grafting [CABG] + OMT...
May 31, 2018: Atherosclerosis
Bastian Balcer, Iryna Dykun, Thomas Schlosser, Michael Forsting, Tienush Rassaf, Amir A Mahabadi
BACKGROUND AND AIMS: We aimed to determine the association of pericoronary adipose tissue (PCAT) volume and attenuation with culprit lesions in the underlying coronary segment in patients with acute myocardial infarction. METHODS: In patients with myocardial infarction, PCAT volume and attenuation surrounding the following segments were manually traced from non-contrast CT imaging: LM, proximal and mid-segment of LAD, RCA, and LCX. PCAT volume and attenuation surrounding culprit and non-culprit lesions were compared...
May 25, 2018: Atherosclerosis
Hanfei Tang, Mengjiao Zhu, Gefei Zhao, Weiguo Fu, Zhenyu Shi, Yong Ding, Xiao Tang, Daqiao Guo
BACKGROUND AND AIMS: Carotid atherosclerotic plaque is one of the main sources of ischemic stroke, and endothelial-to-mesenchymal transition (EndMT) is a major feature of atherosclerosis. Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) activation, stimulated by high glucose, plays an important role in EndMT, and circadian locomotor output cycles protein kaput (Clock) deficiency leads to hyperglycemia and enhanced atherosclerosis in ClockΔ19/Δ19 apolipoprotein E (ApoE)-/- mice...
May 24, 2018: Atherosclerosis
Ki-Chul Sung, Mi Yeon Lee, Young-Hwan Kim, Ji-Hye Huh, Jang-Young Kim, Sarah H Wild, Christopher D Byrne
BACKGROUND AND AIMS: Obesity is frequently associated with non-alcoholic fatty liver disease (NAFLD), insulin resistance (IR), inflammation and metabolic syndrome (MetS), all of which increase the risk of type 2 diabetes (T2DM). However, the role of these risk factors in mediating the effect of obesity remains unclear. We investigated the association between obesity and T2DM in the absence and presence of NAFLD, IR, inflammation and MetS components. METHODS: 29,836 obese subjects without diabetes were studied in a Korean health screening program...
May 24, 2018: Atherosclerosis
Ananthi Rajamoorthi, Richard G Lee, Ángel Baldán
BACKGROUND AND AIMS: Obesity, hepatosteatosis, and hypertriglyceridemia are components of the metabolic syndrome and independent risk factors for cardiovascular disease. The lipid droplet-associated protein CIDEC (cell death-inducing DFFA-like effector C), known in mice as FSP27 (fat-specific protein 27), plays a key role in maintaining triacylglyceride (TAG) homeostasis in adipose tissue and liver, and controls circulating TAG levels in mice. Importantly, mutations and SNPs in CIDEC are associated with dyslipidemia and altered metabolic function in humans...
May 24, 2018: Atherosclerosis
Yume Imahori, David A Leon
No abstract text is available yet for this article.
May 24, 2018: Atherosclerosis
Milton Fabian Suárez-Ortegón, Eduardo Ensaldo-Carrasco, Ting Shi, Stela McLachlan, José Manuel Fernández-Real, Sarah H Wild
BACKGROUND AND AIMS: Mechanisms for the association between iron stores and risk factors for diabetes and cardiovascular disease, such as metabolic syndrome (MetS) and its components, are still not clear. We evaluated the associations between ferritin levels, MetS and its individual components, and potential role of confounding, in a meta-analysis. METHODS: We searched articles in MEDLINE and EMBASE until February 14th, 2018. There were two approaches: meta-analysis of 1) cross-sectional and longitudinal studies and 2) only cross-sectional studies...
May 23, 2018: Atherosclerosis
Daniel E Venegas-Pino, Andrew Lagrotteria, Pei-Wen Wang, Jaiya Morphet, Cassaundra Clapdorp, Yuanyuan Shi, Geoff H Werstuck
BACKGROUND AND AIMS: Diabetic patients with no history of cardiac infarction have a prevalence of coronary atherosclerosis and a risk of heart attack equivalent to euglycemic patients who have coronary atherosclerosis and have suffered a prior myocardial infarction. Although several murine models of diabetes have been established, none of these show indications of cardiac events. In an attempt to establish a diabetic mouse model with coronary atherosclerosis and myocardial injury, we have fed hyperglycemic ApoE-/- :Ins2+/Akita mice a western diet to enhance the dyslipidemic phenotype...
May 23, 2018: Atherosclerosis
Mehmet Eyuboglu
No abstract text is available yet for this article.
May 23, 2018: Atherosclerosis
Elisa Waldmann, Anja Vogt, Alexander Crispin, Julia Altenhofer, Ina Riks, Klaus Georg Parhofer
No abstract text is available yet for this article.
May 22, 2018: Atherosclerosis
Jun Shu, Gaetano Santulli
No abstract text is available yet for this article.
May 22, 2018: Atherosclerosis
Aiko Shimokado, Yoshiki Matsuo, Takashi Kubo, Tsuyoshi Nishiguchi, Akira Taruya, Ikuko Teraguchi, Yasutsugu Shiono, Makoto Orii, Takashi Tanimoto, Takashi Yamano, Yasushi Ino, Takeshi Hozumi, Atsushi Tanaka, Yasuteru Muragaki, Takashi Akasaka
BACKGROUND AND AIMS: The aim of this study was to assess agreement between optical coherence tomography (OCT) and histopathology for healed coronary plaques (HCPs) in human coronary arteries ex vivo, and to evaluate the prevalence and characteristics of HCPs in vivo. METHODS: Ex vivo OCT images were co-registered with histopathology in 144 cross-sections with ≥50% stenosis. Of these, 30 randomly selected pairs were employed to define morphological features of OCT for HCPs (OCT-derived HCPs); the remaining 114 pairs were used to evaluate the accuracy of OCT in detecting histologically-defined HCPs...
May 21, 2018: Atherosclerosis
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