journal
MENU ▼
Read by QxMD icon Read
search

Atherosclerosis

journal
https://www.readbyqxmd.com/read/29432935/uric-acid-is-associated-with-long-term-adverse-cardiovascular-outcomes-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#1
Maximilian Tscharre, Robert Herman, Miklos Rohla, Christina Hauser, Serdar Farhan, Matthias K Freynhofer, Kurt Huber, Thomas W Weiss
BACKGROUND AND AIMS: Evidence links uric acid (UA) with the promotion of cardiovascular disease. We assessed the prognostic value of UA on long-term major adverse outcomes (MACE) in patients with acute coronary syndrome (ACS), undergoing percutaneous coronary intervention (PCI). METHODS: As primary endpoint, we assessed the association of UA (continuous and dichotomized) with MACE, including cardiovascular death, myocardial infarction (MI) and stroke, using Cox regression and propensity matching...
February 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29432933/arterial-stiffening-and-thickening-in-patients-with-pseudoxanthoma-elasticum
#2
Guido Kranenburg, Frank L J Visseren, Gert Jan de Borst, Pim A de Jong, Wilko Spiering
BACKGROUND AND AIMS: Patients with pseudoxanthoma elasticum (PXE), a monogenetic calcification disease, are at high vascular risk. Although the precise arterial phenotype remains unestablished, it is hypothesized that PXE predominantly affects the medial arterial layer leading to arterial stiffening. We aimed to test this hypothesis by measuring arterial wall characteristics in PXE and comparisons with the general population and diabetes mellitus type 2 (DM2), a condition typically associated with mixed intimal and medial arterial disease...
February 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29448980/determination-of-the-optimal-cut-off-value-of-serum-uric-acid-concentration-in-patients-with-acute-coronary-syndrome
#3
LETTER
Zulkif Tanriverdi, Feyzullah Besli, Fatih Gungoren, İbrahim Halil Altiparmak, Asuman Bicer Yesilay
No abstract text is available yet for this article.
February 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29425961/risk-of-acute-coronary-syndrome-and-peripheral-arterial-disease-in-chronic-liver-disease-and-cirrhosis-a-nationwide-population-based-study
#4
Shih-Yi Lin, Cheng-Li Lin, Cheng-Chieh Lin, I-Kuan Wang, Wu-Huei Hsu, Chia-Hung Kao
BACKGROUND & AIMS: Until now, no study has investigated the risks of acute coronary syndrome (ACS) and peripheral arterial disease (PAD) in cirrhosis. METHODS: In this study, 57,214 patients diagnosed with cirrhosis between 2000 and 2010 were identified from the Taiwan National Health Insurance claims data. Each patient was randomly selected and frequency-matched with an individual without cirrhosis by age, sex, and index year. RESULTS: The overall incidence rates of ACS and PAD were 2...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407892/the-impact-of-myocardial-bridge-on-coronary-artery-spasm-and-long-term-clinical-outcomes-in-patients-without-significant-atherosclerotic-stenosis
#5
Purumeh Nam, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND AND AIMS: Myocardial bridge (MB) and coronary artery spasm (CAS) can induce a sustained chest pain, acute coronary syndrome (ACS) and even sudden cardiac death. The aim of this study is to evaluate the relationship between MB and CAS and its impact on long-term clinical outcomes. METHODS: A total of 812 patients with MB without significant coronary artery disease (CAD), who underwent acetylcholine (ACH) provocation test, were enrolled. Significant CAS was defined as ≥70% temporary narrowing by ACH test, and MB was defined as the characteristic phasic systolic compression of the coronary artery with a decrease of more than 30% in diameter on the angiogram after intracoronary nitroglycerin infusion...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407883/vasodilator-response-to-galvanic-current-stimulation-of-the-skin-accurately-detects-acetylsalicylic-acid-intake-a-study-in-400-vascular-patients
#6
Anne-Sophie Florczak, Samir Henni, Isabelle Signolet, Jean-François Hamel, Anne Humeau-Heurtier, Pascal Rousseau, Pierre Abraham
BACKGROUND AND AIMS: The first cause of low-dose acetylsalicylic-acid (ASA) inefficacy is poor adherence to treatment. No non-invasive technique is available to assess ASA intake. Current-induced vasodilation (CIV) was found abolished in healthy volunteers after low-dose ASA intake. We tested clinical characteristics, treatments, and comorbid conditions influencing CIV amplitude in vascular patients. METHODS: CIV was tested in 400 patients (277 males and 123 females, aged 65...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407881/combination-of-biomarkers-of-vascular-calcification-and-stweak-to-predict-cardiovascular-events-in-chronic-kidney-disease
#7
Milica Bozic, Nerea Méndez-Barbero, Carmen Gutiérrez-Muñoz, Angels Betriu, Jesús Egido, Elvira Fernández, Jose L Martín-Ventura, Jose M Valdivielso, Luis M Blanco-Colio
BACKGROUND AND AIMS: Vascular calcification (VC) and atherosclerosis are associated with an increased cardiovascular morbimortality in chronic kidney disease (CKD). Osteoprotegerin (OPG) and osteopontin (OPN) are involved in both VC and CKD. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) has been related to cardiovascular disease. We hypothesized that OPG, OPN and sTWEAK levels may be associated with a higher prevalence of cardiovascular outcomes in patients with CKD...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407880/the-protective-effect-of-resveratrol-on-vascular-aging-by-modulation-of-the-renin-angiotensin-system
#8
Eun Nim Kim, Min Young Kim, Ji Hee Lim, Yaeni Kim, Seok Joon Shin, Cheol Whee Park, Yong-Soo Kim, Yoon Sik Chang, Hye Eun Yoon, Bum Soon Choi
BACKGROUND AND AIMS: This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS: Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and the expression of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), and anti-oxidative enzymes was measured in thoracic aortas of 24-month-old mice...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407878/association-of-carotid-atherosclerosis-and-stiffness-with-abdominal-aortic-aneurysm-the-atherosclerosis-risk-in-communities-aric-study
#9
Lu Yao, Aaron R Folsom, Alvaro Alonso, Pamela L Lutsey, James S Pankow, Weihua Guan, Susan Cheng, Frank A Lederle, Weihong Tang
BACKGROUND AND AIMS: Individuals with atherosclerosis and stiffness often have increased abdominal aortic diameters, but prospective evidence linking them to the risk of abdominal aortic aneurysm (AAA) is limited. METHODS: We prospectively examined the relationship of carotid atherosclerosis and stiffness with future risk of AAA in ARIC. At Visits 1 (1987-89) or 2 (1990-1992), we assessed carotid atherosclerosis (represented by greater carotid intima-media thickness [cIMT] or presence of atherosclerotic plaque) and lower carotid distensibility (reflected by a higher carotid Beta Index)...
February 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407877/association-of-cholesterol-efflux-capacity-with-plasmalogen-levels-of-high-density-lipoprotein-a-cross-sectional-study-in-chronic-kidney-disease-patients
#10
Ryouta Maeba, Ken-Ichiro Kojima, Michito Nagura, Aya Komori, Megumi Nishimukai, Tomoki Okazaki, Shunya Uchida
BACKGROUND AND AIM: Current research suggests that dysfunctional high-density lipoprotein (HDL) with low cholesterol efflux capacity may accelerate atherosclerosis, particularly in chronic kidney disease (CKD). We previously reported that serum levels of plasmalogens closely correlated with HDL concentration, and could serve as a novel biomarker for atherosclerosis. In the present study, we analyzed the association of cholesterol efflux capacity of HDL with clinical and biochemical parameters, including plasmalogens, in CKD patients...
February 1, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29432934/alpha-1-antitrypsin-deficiency-from-the-lung-to-the-heart
#11
Ivan Curjuric, Medea Imboden, Robert Bettschart, Seraina Caviezel, Julia Dratva, Marco Pons, Thomas Rothe, Arno Schmidt-Trucksäss, Daiana Stolz, Gian Andri Thun, Arnold von Eckardstein, Florian Kronenberg, Ilaria Ferrarotti, Nicole M Probst-Hensch
BACKGROUND AND AIMS: Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational dust and fumes, genetic A1AT deficiency can cause chronic obstructive pulmonary disease, a condition with elevated cardiovascular risk. The effects of A1AT deficiency on cardiovascular risk have hardly been studied today. METHODS: Using data from 2614 adults from the population-based SAPALDIA cohort, we tested associations of serum A1AT and SERPINA1 mutations with carotid intima-media thickness (CIMT, measured by B-mode ultrasonography) or self-reported arterial hypertension or cardiovascular disease in multiple regression models using a Mendelian Randomization like analysis design...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29425960/quercetin-decreases-the-activity-of-matrix-metalloproteinase-2-and-ameliorates-vascular-remodeling-in-renovascular-hypertension
#12
Sherliane C Pereira, Juliana M Parente, Vanessa A Belo, Atlante S Mendes, Natália A Gonzaga, Gabriel T do Vale, Carla S Ceron, José Eduardo Tanus-Santos, Carlos R Tirapelli, Michele M Castro
BACKGROUND AND AIMS: Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling. METHODS: Male two-kidney one-clip (2K1C) hypertensive Wistar rats and controls were treated with quercetin (10 mg/kg/day) or its vehicle for three weeks by gavage...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407894/low-sleep-quality-is-associated-with-progression-of-arterial-stiffness-in-patients-with-cardiovascular-risk-factors-hscaa-study
#13
Manabu Kadoya, Masafumi Kurajoh, Miki Kakutani-Hatayama, Akiko Morimoto, Akio Miyoshi, Kae Kosaka-Hamamoto, Takuhito Shoji, Yuji Moriwaki, Masaaki Inaba, Hidenori Koyama
BACKGROUND AND AIMS: Improvement in sleep quality is considered to be a viable target for prevention and treatment of cardiovascular diseases. To gain insight into its underlying mechanisms, we evaluated the significance of objectively measured sleep quality in patients with regard to progression of arterial stiffness over a 3-year follow-up period. METHODS: This prospective cohort study included 306 serial patients registered in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) study...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407893/atherosclerotic-intracranial-internal-carotid-artery-calcification-and-intravenous-thrombolytic-therapy-for-acute-ischemic-stroke
#14
Rahsan Gocmen, Ethem Murat Arsava, Kader Karli Oguz, Mehmet Akif Topcuoglu
BACKGROUND AND AIMS: Intracranial internal carotid artery calcification (IICAC) is a frequent and readily available finding in acute stroke patients treated with intravenous (IV) tissue plasminogen activator (tPA). We aimed to investigate the effects of IICAC subtype (medial and intimal) on the response to IV tPA. METHODS: In this retrospective study, 91 (57% female, age 69 ± 13 years) consecutive acute anterior circulation stroke patients treated with IV tPA were included...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407891/fluid-shear-stress-regulates-the-expression-of-lectin-like-oxidized-low-density-lipoprotein-receptor-1-via-klf2-ap-1-pathway-depending-on-its-intensity-and-pattern-in-endothelial-cells
#15
Ji Yoon Lee, Jihwa Chung, Kyoung Hwa Kim, Shung Hyun An, Minsuk Kim, Junbeom Park, Kihwan Kwon
BACKGROUND AND AIMS: Vascular endothelial cells (ECs) are exposed to fluid shear stress (FSS), which modulates vascular pathophysiology. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is crucial in endothelial dysfunction and atherosclerosis. We elucidated the mechanism regulating LOX-1 expression in ECs by FSS. METHODS: Human umbilical vein endothelial cells were exposed to laminar shear stress (LSS) of indicated intensities using a unidirectional steady flow, or to oscillatory shear stress (OSS) using a bidirectional disturbed flow...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407882/the-cost-effectiveness-of-screening-strategies-for-familial-hypercholesterolaemia-in-poland
#16
Aleksandra Pelczarska, Michał Jakubczyk, Joanna Jakubiak-Lasocka, Maciej Banach, Małgorzata Myśliwiec, Marcin Gruchała, Maciej Niewada
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) elevates the cholesterol level and increases the risk of coronary events and death. Early detection and treatment reduce this risk. We aimed to determine the cost-effectiveness of FH screening in Poland in children, first job takers, and after an acute coronary syndrome (ACS) event, each followed by a cascade screening in the relatives of the positively-diagnosed subjects. METHODS: A decision tree was constructed to model the diagnosis process...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407879/lipoprotein-profile-assessed-by-2d-1h-nmr-and-subclinical-atherosclerosis-in-children-with-familial-hypercholesterolaemia
#17
Cèlia Rodríguez-Borjabad, Daiana Ibarretxe, Josefa Girona, Raimon Ferré, Albert Feliu, Núria Amigó, Eugenio Guijarro, Luis Masana, Núria Plana
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is underdiagnosed in children. In addition to lipid concentrations, lipoprotein particle quantity and quality could influence cardiovascular risk. We aimed to perform a comprehensive plasma lipid study, including lipoprotein particle number and size assessment by two-dimensional nuclear magnetic resonance (2D-1H-NMR), in children with FH compared to non-affected children and to evaluate the clinical value of these factors as subclinical atherosclerosis biomarkers...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29402404/prognostic-value-of-supar-and-hs-crp-on-cardiovascular-disease
#18
Marie Zöga Diederichsen, Søren Zöga Diederichsen, Hans Mickley, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Kent Lodberg Christensen, Michael Hecht Olsen, Axel Diederichsen, Mette Hjortdal Grønhøj
BACKGROUND AND AIMS: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. METHODS: A population sample of 1179 subjects, free of CV disease was included...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407890/selective-inhibition-of-endothelial-nf-%C3%AE%C2%BAb-signaling-attenuates-chronic-intermittent-hypoxia-induced-atherosclerosis-in-mice
#19
Dongmei Song, Guoqiang Fang, Sun-Zhong Mao, Xiaobing Ye, Gang Liu, Edmund J Miller, Harly Greenberg, Shu Fang Liu
BACKGROUND AND AIMS: Chronic intermittent hypoxia (CIH) exposure causes atherosclerosis, although the underlying mechanisms are poorly understood. This study defines the role of endothelial intrinsic NF-κB signaling in the atherogenic response to CIH. METHODS: We created ApoE-ECI-κBmt mice that are deficient in the apolipoprotein E gene (ApoE-/-) and overexpress an I-κBα mutant (I-κBmt) selectively in endothelial cells. ApoE-/- and ApoE-ECI-κBmt mice were fed a normal chow diet (NCD) or high cholesterol diet (HCD) and exposed to sham or CIH, and atherosclerotic lesions were quantified...
January 30, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407889/microrna-24-aggravates-atherosclerosis-by-inhibiting-selective-lipid-uptake-from-hdl-cholesterol-via-the-post-transcriptional-repression-of-scavenger-receptor-class-b-type-i
#20
Kun Ren, Xiao Zhu, Zhi Zheng, Zhong-Cheng Mo, Xiao-Shan Peng, Yong-Zhi Zeng, Han-Xiao Ou, Qing-Hai Zhang, Hui-Zhou Qi, Guo-Jun Zhao, Guang-Hui Yi
BACKGROUND AND AIMS: Liver scavenger receptor class B type I (SR-BI) exerts atheroprotective effects through selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C). Low hepatic SR-BI expression leads to high HDL-C levels in the circulation and an increased risk of atherosclerosis. Furthermore, macrophage SR-BI mediates bidirectional cholesterol flux and may protect against atherogenesis. Previous studies have revealed that miR-24 is closely related to cardiovascular disease (CVD) progression...
January 30, 2018: Atherosclerosis
journal
journal
22445
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"