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Schizophrenia Bulletin

Lénie J Torregrossa, Matthew A Snodgress, Seok Jin Hong, Heathman S Nichols, Enrico Glerean, Lauri Nummenmaa, Sohee Park
Objective: Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feature of schizophrenia (SZ) is characterized by the presence of bodily self-disturbances and social-emotional deficits, we hypothesized that embodiment of emotion would be disrupted in SZ...
December 14, 2018: Schizophrenia Bulletin
Gregory P Strauss, Anthony O Ahmed, Jared W Young, Brian Kirkpatrick
No abstract text is available yet for this article.
December 12, 2018: Schizophrenia Bulletin
Jessica C Bird, Robin Evans, Felicity Waite, Bao S Loe, Daniel Freeman
Background: Adolescence can be a challenging time, characterized by self-consciousness, heightened regard for peer acceptance, and fear of rejection. Interpersonal concerns are amplified by unpredictable social interactions, both online and offline. This developmental and social context is potentially conducive to the emergence of paranoia. However, research on paranoia during adolescence is scarce. Method: Our aim was to examine the prevalence, structure, and probabilistic causal mechanisms of adolescent paranoia...
December 10, 2018: Schizophrenia Bulletin
Matilda Azis, Gregory P Strauss, Elaine Walker, William Revelle, Richard Zinbarg, Vijay Mittal
Background: Negative symptoms occur early in the clinical high risk (CHR) state and indicate increased risk of conversion to psychotic disorder and poor functional outcome. However, while the negative symptom domain has shown to be parsimoniously explained by a 2-factor construct in schizophrenia, there has yet to be an established factor structure of negative symptoms in CHR. Methods: 214 individuals meeting the Structured Interview for Psychosis-Risk Syndromes (SIPS) criteria for CHR were recruited through 3 active research programs in the United States...
December 8, 2018: Schizophrenia Bulletin
Xiaofen Zong, Maolin Hu, Spiro P Pantazatos, J John Mann, Gaohua Wang, Yanhui Liao, Zhong-Chun Liu, Wei Liao, Tao Yao, Zongchang Li, Ying He, Luxian Lv, Deen Sang, Jinsong Tang, Huafu Chen, Junjie Zheng, Xiaogang Chen
Respective changes in functional and anatomical connectivities of default mode network (DMN) after antipsychotic treatment have been reported. However, alterations in structure-function coupling after treatment remain unknown. We performed diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging in 42 drug-naive first-episode schizophrenia patients (FESP) both at baseline and after 8-weeks risperidone monotherapy, and in 38 healthy volunteers. Independent component analysis was used to assess voxel-wise DMN synchrony...
December 2, 2018: Schizophrenia Bulletin
Pei-Chi Tu, Ya Mei Bai, Cheng-Ta Li, Mu-Hong Chen, Wei-Chen Lin, Wan-Chen Chang, Tung-Ping Su
Background: Recent genetic and imaging analyses of large datasets suggested that common biological substrates exist across psychiatric diagnoses. Functional connectivity (FC) abnormalities of thalamocortical circuits were consistently found in patients with schizophrenia but have been less studied in other major psychiatric disorders. This study aimed to examine thalamocortical FC in 4 major psychiatric disorders to identify the common connectivity abnormalities across major psychiatric disorders...
December 1, 2018: Schizophrenia Bulletin
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2018: Schizophrenia Bulletin
Jason A Jepson
No abstract text is available yet for this article.
November 28, 2018: Schizophrenia Bulletin
Jason A Jepson
No abstract text is available yet for this article.
November 28, 2018: Schizophrenia Bulletin
Georgia Koppe, Sinan Guloksuz, Ulrich Reininghaus, Daniel Durstewitz
The rapid rise and now widespread distribution of handheld and wearable devices, such as smartphones, fitness trackers, or smartwatches, has opened a new universe of possibilities for monitoring emotion and cognition in everyday-life context, and for applying experience- and context-specific interventions in psychosis. These devices are equipped with multiple sensors, recording channels, and app-based opportunities for assessment using experience sampling methodology (ESM), which enables to collect vast amounts of temporally highly resolved and ecologically valid personal data from various domains in daily life...
November 28, 2018: Schizophrenia Bulletin
Vijay A Mittal, Sebastian Walther
No abstract text is available yet for this article.
November 28, 2018: Schizophrenia Bulletin
Tudi Gozé, Marcin Moskalewicz, Michael A Schwartz, Jean Naudin, Jean-Arthur Micoulaud-Franchi, Michel Cermolacce
The "Praecox Feeling" (PF) is a classical concept referring to a characteristic feeling of bizarreness experienced by a psychiatrist while encountering a person with schizophrenia. Although the PF used to be considered a core symptom of the schizophrenia spectrum, it fell into disuse since the spread of operationalized diagnostic methods (Diagnostic and Statistical Manual of Mental Disorders/International Classification of Diseases systems). In contemporary research on schizophrenia, it remains largely unaddressed...
November 23, 2018: Schizophrenia Bulletin
Tao Tan, Wei Wang, Jamal Williams, Kaijie Ma, Qing Cao, Zhen Yan
A combination of genetic and environmental risk factors has been considered as the pathogenic cause for mental disorders including schizophrenia. Here, we sought to find out whether the abnormality of the dopamine system, coupled with the exposure to modest stress, is sufficient to trigger the manifestation of schizophrenia-like behaviors. We found that exposing dopamine D4 receptor knockout (D4KO) mice with 1-week restraint stress (2 h/d) induced significant deficits in sensorimotor gating, cognitive processes, social engagement, as well as the elevated exploratory behaviors, which are reminiscent to schizophrenia phenotypes...
November 22, 2018: Schizophrenia Bulletin
Faith Dickerson, Lorraine Jones-Brando, Glen Ford, Giulio Genovese, Cassie Stallings, Andrea Origoni, Colm O'Dushlaine, Emily Katsafanas, Kevin Sweeney, Sunil Khushalani, Robert Yolken
Background: Epstein-Barr virus (EBV) is a highly prevalent human herpesvirus capable of infecting the central nervous system and establishing persistent infection. Methods: We employed solid phase immunoassay techniques to measure immunoglobulin G (IgG) class antibodies to EBV virions and defined proteins in 432 individuals with schizophrenia and 311 individuals without a history of a psychiatric disorder. Western blot testing was performed to document reactivity to specific EBV proteins...
November 20, 2018: Schizophrenia Bulletin
Enda M Byrne, Manuel A R Ferreira, Angli Xue, Sara Lindström, Xia Jiang, Jian Yang, Douglas F Easton, Naomi R Wray, Georgia Chenevix-Trench
Observational epidemiological studies have found an association between schizophrenia and breast cancer, but it is not known if the relationship is a causal one. We used summary statistics from very large genome-wide association studies of schizophrenia (n = 40675 cases and 64643 controls) and breast cancer (n = 122977 cases and 105974 controls) to investigate whether there is evidence that the association is partly due to shared genetic risk factors and whether there is evidence of a causal relationship. Using LD-score regression, we found that there is a small but significant genetic correlation (rG) between the 2 disorders (rG = 0...
November 19, 2018: Schizophrenia Bulletin
Toby Pillinger, Emanuele F Osimo, Stefan Brugger, Valeria Mondelli, Robert A McCutcheon, Oliver D Howes
Immune parameters are elevated in psychosis, but it is unclear whether alterations are homogenous across patients or heterogeneity exists, consistent with the hypothesis that immune alterations are specific to a subgroup of patients. To address this, we examine whether antipsychotic-naïve first-episode psychosis patients exhibit greater variability in blood cytokines, C-reactive protein, and white cell counts compared with controls, and if group mean differences persist after adjusting for skewed data and potential confounds...
November 8, 2018: Schizophrenia Bulletin
Umair Akram
No abstract text is available yet for this article.
November 5, 2018: Schizophrenia Bulletin
Paul Hutton, Francesca Di Rienzo, Douglas Turkington, Helen Spencer, Peter Taylor
Between 5% and 10% of people with psychosis will die by suicide, a rate which is 20-75 times higher than the general population. This risk is even greater in those not taking antipsychotic medication. We examined whether negative appraisals of psychotic experiences and negative metacognitive beliefs about losing mental control mediated a relationship between psychotic symptoms and suicidal ideation in this group. Participants were diagnosed with schizophrenia spectrum disorders, antipsychotic-free for 6 months at baseline, and were participating in an 18-month randomized controlled trial of cognitive therapy vs treatment as usual...
November 2, 2018: Schizophrenia Bulletin
Andreas Heinz, Graham K Murray, Florian Schlagenhauf, Philipp Sterzer, Anthony A Grace, James A Waltz
Psychotic experiences may be understood as altered information processing due to aberrant neural computations. A prominent example of such neural computations is the computation of prediction errors (PEs), which signal the difference between expected and experienced events. Among other areas showing PE coding, hippocampal-prefrontal-striatal neurocircuits play a prominent role in information processing. Dysregulation of dopaminergic signaling, often secondary to psychosocial stress, is thought to interfere with the processing of biologically important events (such as reward prediction errors) and result in the aberrant attribution of salience to irrelevant sensory stimuli and internal representations...
November 2, 2018: Schizophrenia Bulletin
Abigail C Wright, Geoff Davies, David Fowler, Kathryn E Greenwood
Background: Self-defining memories (SDMs) are vivid personal memories, related to narrative identity. Individuals with schizophrenia report less specific, more negative, and extract less meaning from these memories compared to control groups. SDMs have been shown to be predicted by neurocognition, associated with metacognition, and linked to goal outcomes in healthy controls. As neurocognition and metacognition are known predictors of poor functioning in psychosis, SDMs may also be a predictor...
November 2, 2018: Schizophrenia Bulletin
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