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Schizophrenia Bulletin

Christian Núñez, Christian Stephan-Otto, Judith Usall, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Laura Pina-Camacho, Eduard Vieta, Josefina Castro-Fornieles, Roberto Rodriguez-Jimenez, Anna Butjosa, Joost Janssen, Bibiana Cabrera, Mara Parellada, Miquel Bernardo
Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated...
August 10, 2018: Schizophrenia Bulletin
May-May Meijer
No abstract text is available yet for this article.
August 10, 2018: Schizophrenia Bulletin
Lindsay D Oliver, John D Haltigan, James M Gold, George Foussias, Pamela DeRosse, Robert W Buchanan, Anil K Malhotra, Aristotle N Voineskos
Background: Schizophrenia spectrum disorders (SSDs) often feature social cognitive deficits. However, little work has focused on the factor structure of social cognition, and results have been inconsistent in schizophrenia. This study aimed to elucidate the factor structure of social cognition across people with SSDs and healthy controls. It was hypothesized that a 2-factor model, including lower-level "simulation" and higher-level "mentalizing" factors, would demonstrate the best fit across participants...
August 10, 2018: Schizophrenia Bulletin
Yu-Han Chen, Breannan Howell, J Christopher Edgar, Mingxiong Huang, Peter Kochunov, Michael A Hunter, Cassandra Wootton, Brett Y Lu, Juan Bustillo, Joseph R Sadek, Gregory A Miller, José M Cañive
Background: Auditory encoding abnormalities, gray-matter loss, and cognitive deficits are all candidate schizophrenia (SZ) endophenotypes. This study evaluated associations between and heritability of auditory network attributes (function and structure) and attention in healthy controls (HC), SZ patients, and unaffected relatives (UR). Methods: Whole-brain maps of M100 auditory activity from magnetoencephalography recordings, cortical thickness (CT), and a measure of attention were obtained from 70 HC, 69 SZ patients, and 35 UR...
August 7, 2018: Schizophrenia Bulletin
Michelle N Servaas, Claire Kos, Nicolás Gravel, Remco J Renken, Jan-Bernard C Marsman, Marie-José van Tol, André Aleman
The aim of this study was to investigate whether apathy in schizophrenia is associated with rigidity in behavior and brain functioning. To this end, we studied associations between variability in dynamic functional connectivity (DFC) in relevant functional brain networks, apathy, and variability in physical activity in schizophrenia. Thirty-one patients with schizophrenia, scoring high on apathy, were included and wore an actigraph. Activity variability was calculated on the activity counts using the root of the Mean Squared Successive Difference (MSSD)...
July 24, 2018: Schizophrenia Bulletin
(no author information available yet)
No abstract text is available yet for this article.
July 16, 2018: Schizophrenia Bulletin
Michele Poletti, Eva Gebhardt, Marianne N Kvande, Judith Ford, Andrea Raballo
The motor system in its manifold articulations is receiving increasing clinical and research attention. This is because motor impairments constitute a central, expressive component of the mental state examination and a key transdiagnostic feature indexing disease severity. Furthermore, within the schizophrenia spectrum, the integration of neurophysiological, developmental, and phenomenological perspectives suggests that motor impairment is not simply a generic, extrinsic proxy of an altered neurodevelopment, but might be more intimately related to psychotic risk...
July 11, 2018: Schizophrenia Bulletin
May-May Meijer, Femke Meijer
No abstract text is available yet for this article.
July 9, 2018: Schizophrenia Bulletin
Neeraj Tandon, Rajiv Tandon
No abstract text is available yet for this article.
July 9, 2018: Schizophrenia Bulletin
Anna L Moon, Niels Haan, Lawrence S Wilkinson, Kerrie L Thomas, Jeremy Hall
Large-scale genome-wide association studies have consistently shown that genetic variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit alpha1C, increases risk for psychiatric disorders. CACNA1C encodes the Cav1.2 subunit of voltage-gated calcium channels, which themselves have been functionally implicated in a broad spectrum of neuropsychiatric syndromes. Research has concentrated on uncovering the underlying biological mechanisms that could be responsible for this increased risk. This review presents an overview of recent findings regarding Cacna1c variation in animal models, particularly focusing on behavioral phenotypes associated with neurodevelopmental disorders such as cognition, anxiety and depressive phenotypes, and fear conditioning...
July 4, 2018: Schizophrenia Bulletin
(no author information available yet)
No abstract text is available yet for this article.
July 3, 2018: Schizophrenia Bulletin
Aisling O'Neill, Andrea Mechelli, Sagnik Bhattacharyya
Objective: Increasingly, studies have identified abnormalities in the functional connectivity (FC) of large-scale neural networks in early psychosis, but the findings thus far have been inconclusive. Therefore, the aim of this study was to identify robust alterations in FC of the default mode (DMN), salience (SN), and central executive networks (CEN), in patients with first-episode psychosis (FEP) using a meta-analytic approach. Methods: Included studies were required to be resting-state, seed-to-whole brain, FC neuroimaging studies, comparing FEP patients to healthy controls (HC), with seeds within the boundaries of the region-of-interest networks...
July 3, 2018: Schizophrenia Bulletin
Jason A Jepson
No abstract text is available yet for this article.
July 2, 2018: Schizophrenia Bulletin
Myrto T Samara, Adriani Nikolakopoulou, Georgia Salanti, Stefan Leucht
Objective: An important clinical question is how many patients with acute schizophrenia do not respond to antipsychotics despite being treated for adequate time and with an effective dose. However, up to date, the exact extent of the phenomenon remains unclear. Methods: We calculated the nonresponse and nonremission percentages using individual patient data from 16 randomized controlled trials (RCTs). Six thousand two hundred twenty-one patients were assigned to one antipsychotic (amisulpride, flupenthixol, haloperidol, olanzapine, quetiapine, risperidone, or ziprasidone) at an adequate dose; the response was assessed at 4-6 weeks...
July 2, 2018: Schizophrenia Bulletin
Caroline Wüsten, Björn Schlier, Edo S Jaya, Eduardo Fonseca-Pedrero, Emmanuelle Peters, Hélène Verdoux, Todd S Woodward, Tim B Ziermans, Tania M Lincoln
Psychotic experiences (PEs) are common in the general population but do not necessarily reflect a risk status if they occur in relative isolation or are not distressing. Emerging evidence suggests that PEs might be experienced as more benign for individuals from collectivistic low- and middle-income countries (LAMIC) compared with individualistic high-income countries (HIC). The aim of this study was to determine whether: (1) self-reported PEs are less distressing in community samples from LAMIC than from HIC; (2) the network of PEs is significantly less connected in a sample from LAMIC than from HIC...
June 30, 2018: Schizophrenia Bulletin
(no author information available yet)
No abstract text is available yet for this article.
June 28, 2018: Schizophrenia Bulletin
George K Lewis
There is evidence that many diseases are accompanied by immunological perturbations and even when the perturbations are not directly pathogenic, they can provide correlative signatures of pathology that can be useful diagnostically. For example, the neuromuscular disease, multiple sclerosis, has a pathophysiology that is immunologically mediated, evinced by the use of increasingly sophisticated immunosuppression therapy and by animal studies in which many of the symptoms can be reproduced by breaking immunological tolerance to myelin basic protein...
June 27, 2018: Schizophrenia Bulletin
Sugai Liang, Yinfei Li, Zhong Zhang, Xiangzhen Kong, Qiang Wang, Wei Deng, Xiaojing Li, Liansheng Zhao, Mingli Li, Yajing Meng, Feng Huang, Xiaohong Ma, Xin-Min Li, Andrew J Greenshaw, Junming Shao, Tao Li
Recent neuroanatomical pattern recognition studies have shown some promises for developing an objective neuroimaging-based classification related to schizophrenia. This study explored the feasibility of reliably identifying schizophrenia using single and multimodal multivariate neuroimaging features. Multiple brain measures including regional gray matter (GM) volume, cortical thickness, gyrification, fractional anisotropy (FA), and mean diffusivity (MD) were extracted using fully automated procedures. We used Gradient Boosting Decision Tree to identify the most frequently selected features of each set of neuroanatomical metric and fused multimodal measures...
June 27, 2018: Schizophrenia Bulletin
Qiang Wang, Jie Zhang, Zhaowen Liu, Tim J Crow, Kai Zhang, Mingli Li, Liansheng Zhao, Xiaojing Li, Wei Deng, Wanjun Guo, Xiaohong Ma, Wei Cheng, Liang Ma, Lin Wan, Guangming Lu, Zhening Liu, Jijun Wang, Jianfeng Feng, Tao Li
Schizophrenia is genetic in origin and associated with a fecundity disadvantage. The deficits in schizophrenia have been attributed to variation related to the human capacity for language or brain laterality. How sex influences the relative connectivity of the 2 hemispheres is a route to understanding these 2 functions. Using resting-state functional magnetic resonance imaging (fMRI) we searched for sex- and hemisphere-specific changes in whole-brain functional-connectivity in multi-site datasets (altogether 672 subjects including 286 patients, all right-handed) in the first-episode schizophrenia (illness duration ≤ 1 year, mostly drug naive) and in chronic stages of schizophrenia (illness duration > 1 year), respectively...
June 25, 2018: Schizophrenia Bulletin
(no author information available yet)
No abstract text is available yet for this article.
June 25, 2018: Schizophrenia Bulletin
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