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Stroke; a Journal of Cerebral Circulation

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https://www.readbyqxmd.com/read/29789396/patient-reported-outcome-measures-proms-for-acute-stroke-rationale-methods-and-future-directions
#1
REVIEW
Mathew Reeves, Lynda Lisabeth, Linda Williams, Irene Katzan, Moira Kapral, Anne Deutsch, Janet Prvu-Bettger
No abstract text is available yet for this article.
May 22, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29789395/blood-pressure-attained-analysis-of-atach-2-trial
#2
Adnan I Qureshi, Yuko Y Palesch, Lydia D Foster, William G Barsan, Joshua N Goldstein, Daniel F Hanley, Chung Y Hsu, Claudia S Moy, Mushtaq H Qureshi, Robert Silbergleit, Jose I Suarez, Kazunori Toyoda, Haruko Yamamoto
BACKGROUND AND PURPOSE: We compared the rates of death or disability, defined by modified Rankin Scale score of 4 to 6, at 3 months in patients with intracerebral hemorrhage according to post-treatment systolic blood pressure (SBP)-attained status. METHODS: We divided 1000 subjects with SBP ≥180 mm Hg who were randomized within 4.5 hours of symptom onset as follows: SBP <140 mm Hg achieved or not achieved within 2 hours; subjects in whom SBP <140 mm Hg was achieved within 2 hours were further divided: SBP <140 mm Hg for 21 to 22 hours (reduced and maintained) or SBP was ≥140 mm Hg for at least 2 hours during the period between 2 and 24 hours (reduced but not maintained)...
May 22, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29789394/joining-a-multicenter-clinical-trial
#3
REVIEW
Zixiao Li, Janet Prvu Bettger, Liping Liu, Yongjun Wang
No abstract text is available yet for this article.
May 22, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29789393/long-term-outcomes-in-patients-aged-%C3%A2-70-years-with-intravenous-glyburide-from-the-phase-ii-games-rp-study-of-large-hemispheric-infarction-an-exploratory-analysis
#4
Kevin N Sheth, Nils H Petersen, Ken Cheung, Jordan J Elm, Holly E Hinson, Bradley J Molyneaux, Lauren A Beslow, Gordon K Sze, J Marc Simard, W Taylor Kimberly
BACKGROUND AND PURPOSE: We aimed to determine whether subjects aged ≤70 years who were treated with intravenous glyburide (RP-1127; BIIB093; glibenclamide) would have better long-term outcomes than those who received placebo. METHODS: GAMES-RP (Glyburide Advantage in Malignant Edema and Stroke-Remedy Pharmaceuticals) was a prospective, double-blind, randomized, placebo-controlled phase 2 clinical trial. Eighty-six participants, aged 18 to 80 years, who presented to 18 centers with large hemispheric infarction (baseline diffusion-weighted imaging volumes, 82-300 cm3 ) randomized within 10 hours of symptom onset were enrolled...
May 22, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29786566/clinical-performance-measures-for-adults-hospitalized-with-intracerebral-hemorrhage-performance-measures-for-healthcare-professionals-from-the-american-heart-association-american-stroke-association
#5
REVIEW
J Claude Hemphill, Opeolu M Adeoye, David N Alexander, Anne W Alexandrov, Sepideh Amin-Hanjani, Mary Cushman, Mary G George, Peter D LeRoux, Stephan A Mayer, Adnan I Qureshi, Jeffrey L Saver, Lee H Schwamm, Kevin N Sheth, David Tirschwell
No abstract text is available yet for this article.
May 21, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29777016/clinical-utility-of-electronic-alberta-stroke-program-early-computed-tomography-score-software-in-the-enchanted-trial-database
#6
Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I Lindley, John Chalmers, Craig S Anderson
BACKGROUND AND PURPOSE: Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke. METHODS: All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded...
May 18, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29769241/multivessel-occlusion-in-patients-subjected-to-thrombectomy-prevalence-associated-factors-and-clinical-implications
#7
Johannes Kaesmacher, Pascal J Mosimann, Mattia Giarrusso, Marwan El-Koussy, Felix Zibold, Eike Piechowiak, Tomas Dobrocky, Raphael Meier, Simon Jung, Sebastian Bellwald, Marcel Arnold, Pasquale Mordasini, Urs Fischer, Jan Gralla
BACKGROUND AND PURPOSE: Patients with embolic large-vessel occlusion may present with additional coincidental acute occlusions within or distant from the involved territory, referred to as multivessel occlusion (MVO). Purpose of this study was to assess prevalence of MVO, associated factors, and clinical relevance in patients undergoing endovascular stroke treatment. METHODS: Image data of consecutive endovascular candidates (n=720) with direct access to angiography were extracted from a prospective registry...
May 16, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29760278/imaging-endophenotypes-of-stroke-as-a-target-for-genetic-studies
#8
REVIEW
Xueqiu Jian, Myriam Fornage
No abstract text is available yet for this article.
May 14, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29760277/patent-foramen-ovale-closure-versus-medical-therapy-for-cryptogenic-ischemic-stroke-a-topical-review
#9
REVIEW
Jeffrey L Saver, Heinrich P Mattle, David Thaler
No abstract text is available yet for this article.
May 14, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29760276/early-blood-brain-barrier-disruption-in-ischemic-stroke-initiates-multifocally-around-capillaries-venules
#10
Angelika Hoffmann, Tassilo Dege, Reiner Kunze, Anne-Sophie Ernst, Holger Lorenz, Laura-Inés Böhler, Thomas Korff, Hugo H Marti, Sabine Heiland, Martin Bendszus, Xavier Helluy, Mirko Pham
BACKGROUND AND PURPOSE: Detection and localization of the early phase of blood-brain barrier disruption (BBBD) in vivo during cerebral ischemia/reperfusion injury remain a major challenge but may be a relevant outcome parameter in stroke. METHODS: We studied early BBBD in mice after transient middle cerebral artery occlusion by multimodal, high-field (9.4T) in vivo magnetic resonance imaging, including the contrast agent gadofluorineM as an albumin-binding tracer...
May 14, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29760275/targeting-reperfusion-injury-in-the-age-of-mechanical-thrombectomy
#11
REVIEW
Atsushi Mizuma, Je Sung You, Midori A Yenari
No abstract text is available yet for this article.
May 14, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29752348/genetic-study-of-white-matter-integrity-in-uk-biobank-n-8448-and-the-overlap-with-stroke-depression-and-dementia
#12
Loes C A Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain novel insights in the disease mechanism underlying cerebral small vessel disease. The aim was to identify common variants associated with microstructural integrity of the white matter and to elucidate the relationships of white matter structural integrity with stroke, major depressive disorder, and Alzheimer disease...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29752347/synergistic-effects-of-enriched-environment-and-task-specific-reach-training-on-poststroke-recovery-of-motor-function
#13
Matthew Strider Jeffers, Dale Corbett
BACKGROUND AND PURPOSE: Reach training in concert with environmental enrichment provides functional benefits after experimental stroke in rats. The present study extended these findings by assessing whether intensive task-specific reach training or enrichment initiated alone would provide similar functional benefit. Additionally, we investigated whether the 70% recovery rule, or a combined model of initial poststroke impairment, cortical infarct volume, and rehabilitation intensity, could predict recovery in the single-pellet task, as previously found for the Montoya staircase...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29748424/intravenous-recombinant-tissue-type-plasminogen-activator-influence-on-outcome-in-anterior-circulation-ischemic-stroke-treated-by-mechanical-thrombectomy
#14
Marc Ferrigno, Nicolas Bricout, Didier Leys, Laurent Estrade, Charlotte Cordonnier, Thomas Personnic, Maeva Kyheng, Hilde Henon
BACKGROUND AND PURPOSE: Intravenous thrombolysis (IVT) followed by mechanical thrombectomy (MT) improves functional outcome in patients with ischemic stroke related to proximal-vessel occlusion in the anterior circulation. Whether MT alone is as effective as IVT/MT remains controversial. We aimed at evaluating the influence of IVT in patients with large anterior circulation artery occlusion treated with MT. METHODS: We did a prospective observational cohort study in patients with stroke related to large anterior circulation artery occlusion treated by MT who were admitted to Lille University Hospital, Lille, France...
May 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29748423/role-of-myeloid-lineage-cell-autophagy-in-ischemic-brain-injury
#15
Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, Masaaki Korai, Fumiaki Shikata, Atsushi Kuwabara, Xiaoxing Xiong, Caleb Rutledge, Rona G Giffard, Tomoki Hashimoto
BACKGROUND AND PURPOSE: Inflammatory cells play a significant role in secondary injury after ischemic stroke. Recent studies have suggested that a lack of autophagy in myeloid cells causes augmented proinflammatory cytokine release and prolonged inflammation after tissue injury. In this study, we investigated the roles of myeloid cell autophagy in ischemic brain injury. METHODS: Focal cerebral ischemia was induced via transient middle cerebral artery occlusion in mice with autophagy-deficient myeloid lineage cells (Atg5flox/flox LysMCre+) and in their littermate controls (Atg5flox/flox)...
May 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29748422/antiplatelet-treatment-after-transient-ischemic-attack-and-ischemic-stroke-in-patients-with-cerebral-microbleeds-in-2-large-cohorts-and-an-updated-systematic-review
#16
Kui Kai Lau, Caroline E Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Küker, Henry Ka Fung Mak, Peter M Rothwell
BACKGROUND AND PURPOSE: In patients with transient ischemic attack/ischemic stroke, microbleed burden predicts intracerebral hemorrhage (ICH), and ischemic stroke, but implications for antiplatelet treatment are uncertain. Previous cohort studies have had insufficient follow-up to assess the time course of risks, have not stratified risks by antithrombotic use, and have not reported extracranial bleeds or functional outcome of ICH versus ischemic stroke. METHODS: In 2 independent prospective cohorts with transient ischemic attack/ischemic stroke (Oxford Vascular Study/mainly white; University of Hong Kong/mainly Chinese), antiplatelet treatment was started routinely irrespective of microbleed burden...
May 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29748421/in-the-era-of-thrombectomy-let-us-also-protect-the-majority-of-patients-with-stroke-who-only-require-medical-treatment
#17
Enrique C Leira, Sean I Savitz
No abstract text is available yet for this article.
May 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29739917/magnetic-resonance-imaging-selection-for-endovascular-stroke-therapy-workflow-in-the-goliath-trial
#18
Claus Z Simonsen, Albert J Yoo, Mads Rasmussen, Kristina E Sørensen, Thabele Leslie-Mazwi, Grethe Andersen, Leif H Sørensen
BACKGROUND AND PURPOSE: The GOLIATH trial (General or Local Anesthesia in Intra-Arterial Therapy) compared infarct growth and outcome in patients undergoing endovascular therapy under either general anesthesia or conscious sedation. Magnetic resonance imaging was performed before and after the procedure to study infarct growth. In this post hoc analysis of GOLIATH, we aimed to characterize the workflow of patients undergoing magnetic resonance imaging selection before endovascular therapy...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29739916/secondary-stroke-prevention-in-atrial-fibrillation-new-insights-into-an-old-problem
#19
EDITORIAL
M Edip Gurol
No abstract text is available yet for this article.
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29739915/cost-effectiveness-of-left-atrial-appendage-closure-with-the-watchman-device-compared-with-warfarin-or-non-vitamin-k-antagonist-oral-anticoagulants-for-secondary-prevention-in-nonvalvular-atrial-fibrillation
#20
Vivek Y Reddy, Ronald L Akehurst, Stacey L Amorosi, Meghan B Gavaghan, Deanna S Hertz, David R Holmes
BACKGROUND AND PURPOSE: Once a patient with atrial fibrillation experiences an embolic event, the risk of a recurrent event increases 2.6-fold. New treatments have emerged as viable treatment alternatives to warfarin for stroke risk reduction in secondary prevention populations. This analysis sought to assess the cost-effectiveness of left atrial appendage closure (LAAC) compared with warfarin and the non-vitamin K antagonist oral anticoagulants dabigatran 150 mg, apixaban and rivaroxaban in the prevention of stroke in nonvalvular atrial fibrillation patients with a prior stroke or transient ischemic attack...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
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