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Stroke; a Journal of Cerebral Circulation

Kui Kai Lau, Peter M Rothwell
No abstract text is available yet for this article.
September 2018: Stroke; a Journal of Cerebral Circulation
Diana Aguiar de Sousa, Lia Lucas Neto, Patrícia Canhão, José M Ferro
BACKGROUND AND PURPOSE: The role of recanalization of the occluded dural sinus or vein in the outcome of patients with cerebral venous thrombosis (CVT) is not established. We aimed to systematically review, in patients with CVT, (1) the recanalization rate and its association with (2) clinical outcome and (3) CVT recurrence. METHODS: Systematic search in MEDLINE (Medical Literature Analysis and Retrieval System Online), Cochrane Library, and (inception to September 2017)...
July 18, 2018: Stroke; a Journal of Cerebral Circulation
Michael D Hill, Patrik Michel
No abstract text is available yet for this article.
July 17, 2018: Stroke; a Journal of Cerebral Circulation
Dar Dowlatshahi, Richard H Swartz, Luciana Catanese
No abstract text is available yet for this article.
July 17, 2018: Stroke; a Journal of Cerebral Circulation
Isaac García-Yébenes, Alicia García-Culebras, Carolina Peña-Martínez, David Fernández-López, Jaime Díaz-Guzmán, Pilar Negredo, Carlos Avendaño, Mar Castellanos, Teresa Gasull, Antoni Dávalos, María A Moro, Ignacio Lizasoain
BACKGROUND AND PURPOSE: Recanalization with tPA (tissue-type plasminogen activator) is the only pharmacological therapy available for patients with ischemic stroke. However, the percentage of patients who may receive this therapy is limited by the risk of hemorrhagic transformation (HT)-the main complication of ischemic stroke. Our aim is to establish whether iron overload affects HT risk, to identify mechanisms that could help to select patients and to prevent this devastating complication...
July 17, 2018: Stroke; a Journal of Cerebral Circulation
Adam de Havenon, Jennifer J Majersik, Gregory Stoddard, Ka-Ho Wong, J Scott McNally, A Gordon Smith, Natalia S Rost, David L Tirschwell
BACKGROUND AND PURPOSE: Increased systolic blood pressure variability (BPV) is associated with worse outcome after acute ischemic stroke and may also have a negative impact after intracerebral hemorrhage. We sought to determine whether increased BPV was detrimental in the ATACH-2 (Antihypertensive Treatment of Acute Cerebral Hemorrhage II) trial. METHODS: The primary outcome of our study was a 3-month follow-up modified Rankin Scale of 3 to 6, and the secondary outcome was a utility-weighted modified Rankin Scale...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Sergi Martinez-Ramirez, Sanneke van Rooden, Andreas Charidimou, Anna Maria van Opstal, Marieke Wermer, M Edip Gurol, Gisela Terwindt, Jeroen van der Grond, Steven M Greenberg, Mark van Buchem, Anand Viswanathan
BACKGROUND AND PURPOSE: Magnetic resonance imaging visible perivascular spaces in the centrum semiovale (CSO-PVS) have been associated with cerebral amyloid angiopathy (CAA).We aimed to further confirm this link by evaluating CSO-PVS volume in pathologically-demonstrated sporadic and genetically-demonstrated hereditary forms of the disease. METHODS: We studied a retrospective hospital-based cohort consisting of 63 individuals aged >55 having brain magnetic resonance imaging and pathological assessment of CAA (mean age, 73...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
BACKGROUND AND PURPOSE: Although older age is one of the most important risk factor for stroke in atrial fibrillation (AF), the appropriate age threshold (eg, CHA2 DS2 -VASc score [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65-74 years, female], 1 point for age 65-74 years, 2 points for age ≥75 years) for increased risk is controversial because actual age thresholds may differ between countries and ethnic groups...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Beom Joon Kim, Yong-Jin Cho, Keun-Sik Hong, Jun Lee, Joon-Tae Kim, Kang Ho Choi, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Wook-Joo Kim, Dong-Ick Shin, Min-Ju Yeo, Sung Il Sohn, Jeong-Ho Hong, Ji Sung Lee, Juneyoung Lee, Moon-Ku Han, Philip B Gorelick, Hee-Joon Bae
BACKGROUND AND PURPOSE: Blood pressure dynamics in patients with acute ischemic stroke may serve as an important modifiable and prognostic factor. METHODS: A total of 8376 patients with acute ischemic stroke were studied from a prospective multicenter registry. Patients were eligible if they had been admitted within 24 hours of symptom onset and had ≥5 systolic blood pressure (SBP) measurements during the first 24 hours of hospitalization. SBP trajectory groups in the first 24 hours were identified using the TRAJ procedure in SAS software with delta-Bayesian Information Criterion and prespecified modeling parameters...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Toshiya Ishihara, Shoichiro Sato, Toshiyuki Uehara, Tomoyuki Ohara, Mikito Hayakawa, Kazumi Kimura, Yasushi Okada, Yasuhiro Hasegawa, Norio Tanahashi, Akifumi Suzuki, Jyoji Nakagawara, Kazumasa Arii, Shinji Nagahiro, Kuniaki Ogasawara, Shinichiro Uchiyama, Masayasu Matsumoto, Koji Iihara, Kazunori Toyoda, Kazuo Minematsu
BACKGROUND AND PURPOSE: Patients with transient ischemic attack (TIA) occasionally show nonfocal symptoms, such as unconsciousness, amnesia, and unsteadiness. The purpose of this study was to clarify the characteristics and prognosis of patients with TIA with nonfocal symptoms, using data from the PROMISE-TIA (Prospective Multicenter Registry to Identify Subsequent Cardiovascular Events After Transient Ischemic Attack). METHODS: Patients with TIA within 7 days of onset were consecutively enrolled in the Japanese nationwide registry...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Darian R Esfahani, Dilip Pandey, Xinjian Du, Linda Rose-Finnell, Fady T Charbel, Colin P Derdeyn, Sepideh Amin-Hanjani
BACKGROUND AND PURPOSE: The VERiTAS (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke) study demonstrated posterior circulation distal flow status, determined by quantitative magnetic resonance angiography, is a robust predictor of vertebrobasilar stroke risk in patients with symptomatic atherosclerotic vertebrobasilar disease. Flow-compromised high-risk patients may benefit from flow-restoring endovascular procedures, such as submaximal angioplasty. In this study, we examine the cost-effectiveness of quantitative magnetic resonance angiography screening to identify patients who may benefit from submaximal angioplasty to restore vertebrobasilar flow...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Eline J Volkers, Ale Algra, L Jaap Kappelle, Olav Jansen, George Howard, Jeroen Hendrikse, Alison Halliday, John Gregson, Gustav Fraedrich, Hans-Henning Eckstein, David Calvet, Richard Bulbulia, Martin M Brown, Jean-Pierre Becquemin, Peter A Ringleb, Jean-Louis Mas, Leo H Bonati, Thomas G Brott, Jacoba P Greving
BACKGROUND AND PURPOSE: Prediction models may help physicians to stratify patients with high and low risk for periprocedural complications or long-term stroke risk after carotid artery stenting or carotid endarterectomy. We aimed to evaluate external performance of previously published prediction models for short- and long-term outcome after carotid revascularization in patients with symptomatic carotid artery stenosis. METHODS: From a literature review, we selected all prediction models that used only readily available patient characteristics known before procedure initiation...
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Lars Frost, Søren Paaske Johnsen
No abstract text is available yet for this article.
July 16, 2018: Stroke; a Journal of Cerebral Circulation
Xueqiu Jian, Claudia L Satizabal, Albert V Smith, Katharina Wittfeld, Joshua C Bis, Jennifer A Smith, Fang-Chi Hsu, Kwangsik Nho, Edith Hofer, Saskia P Hagenaars, Paul A Nyquist, Aniket Mishra, Hieab H H Adams, Shuo Li, Alexander Teumer, Wei Zhao, Barry I Freedman, Yasaman Saba, Lisa R Yanek, Ganesh Chauhan, Mark A van Buchem, Mary Cushman, Natalie A Royle, R Nick Bryan, Wiro J Niessen, Beverly G Windham, Anita L DeStefano, Mohamad Habes, Susan R Heckbert, Nicholette D Palmer, Cora E Lewis, Gudny Eiriksdottir, Pauline Maillard, Rasika A Mathias, Georg Homuth, Maria Del C Valdés-Hernández, Jasmin Divers, Alexa S Beiser, Sönke Langner, Kenneth M Rice, Mark E Bastin, Qiong Yang, Joseph A Maldjian, John M Starr, Stephen Sidney, Shannon L Risacher, André G Uitterlinden, Vilmundur G Gudnason, Matthias Nauck, Jerome I Rotter, Pamela J Schreiner, Eric Boerwinkle, Cornelia M van Duijn, Bernard Mazoyer, Bettina von Sarnowski, Rebecca F Gottesman, Daniel Levy, Sigurdur Sigurdsson, Meike W Vernooij, Stephen T Turner, Reinhold Schmidt, Joanna M Wardlaw, Bruce M Psaty, Thomas H Mosley, Charles S DeCarli, Andrew J Saykin, Donald W Bowden, Diane M Becker, Ian J Deary, Helena Schmidt, Sharon L R Kardia, M Arfan Ikram, Stéphanie Debette, Hans J Grabe, W T Longstreth, Sudha Seshadri, Lenore J Launer, Myriam Fornage
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) on brain magnetic resonance imaging are typical signs of cerebral small vessel disease and may indicate various preclinical, age-related neurological disorders, such as stroke. Though WMH are highly heritable, known common variants explain a small proportion of the WMH variance. The contribution of low-frequency/rare coding variants to WMH burden has not been explored. METHODS: In the discovery sample we recruited 20 719 stroke/dementia-free adults from 13 population-based cohort studies within the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, among which 17 790 were of European ancestry and 2929 of African ancestry...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Nitin Goyal, Georgios Tsivgoulis, Jason J Chang, Konark Malhotra, Abhi Pandhi, Muhammad F Ishfaq, Diana Alsbrook, Adam S Arthur, Lucas Elijovich, Andrei V Alexandrov
BACKGROUND AND PURPOSE: The purpose of this study is to evaluate the relationship between neutrophil-to-lymphocyte ratio (NLR) at admission with safety and efficacy outcomes in acute stroke patients with large vessel occlusion after mechanical thrombectomy. METHODS: Consecutive large vessel occlusion patients treated with mechanical thrombectomy during a 4-year period were evaluated. Outcome measures included symptomatic intracranial hemorrhage, 3-month mortality, successful reperfusion (modified Thrombolysis in Cerebral Infarction score of 2b/3), and 3-month functional independence (modified Rankin Scale scores of 0-2)...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Li Xiong, Anne-Katrin Giese, Marco Pasi, Andreas Charidimou, Susanne van Veluw, Anand Viswanathan
No abstract text is available yet for this article.
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Ching-Jen Chen, Dale Ding, Hideyuki Kano, David Mathieu, Douglas Kondziolka, Caleb Feliciano, Rafael Rodriguez-Mercado, Inga S Grills, Gene Barnett, L Dade Lunsford, Jason P Sheehan
BACKGROUND AND PURPOSE: The aim of this international, multicenter, retrospective matched cohort study is to directly compare the outcomes after stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVM) in pediatric versus adult patients. METHODS: We performed a retrospective review of patients with AVM who underwent SRS at 8 institutions participating in the International Gamma Knife Research Foundation from 1987 to 2014. Patients were categorized into pediatric (<18 years of age) and adult (≥18 years of age) cohorts and matched in a 1:1 ratio using propensity scores...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Gerrit M Grosse, Pablo Bascuñana, Walter J Schulz-Schaeffer, Omke E Teebken, Mathias Wilhelmi, Hans Worthmann, Tobias L Ross, Hans-Jürgen Wester, Saskia Kropf, Thorsten Derlin, Frank M Bengel, Jens P Bankstahl, Karin Weissenborn
BACKGROUND AND PURPOSE: This pilot study aims to demonstrate the feasibility of targeting molecular characteristics of high-risk atherosclerotic plaque in symptomatic and asymptomatic carotid stenosis (CS), that is, upregulation of the translocator protein (TSPO) and the chemokine receptor type 4 (CXCR4), by means of molecular imaging. METHODS: In a translational setting, specimens of carotid plaques of patients with symptomatic and asymptomatic CS obtained by carotid endarterectomy were analyzed for the presence of TSPO and CXCR4 by autoradiography, using the positron emission tomography tracers 18 F-GE180 and 68 Ga-Pentixafor and evaluated by histopathology...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Kazutaka Uchida, Shinichi Yoshimura, Nagayasu Hiyama, Yoshiharu Oki, Tsuyoshi Matsumoto, Ryo Tokuda, Ikuya Yamaura, Shin Saito, Masataka Takeuchi, Keigo Shigeta, Hayato Araki, Takeshi Morimoto
BACKGROUND AND PURPOSE: Endovascular therapy is effective against acute cerebral large vessel occlusion (LVO). However, many patients do not receive such interventions because of the lack of timely identification of the type of stroke. If the types of stroke (any stroke, LVO, intracranial hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) were to be predicted at the prehospital stage, better access to appropriate interventions would be possible. Japan Urgent Stroke Triage (JUST) score was clinical prediction rule to classify suspected patients of acute stroke into different types at the prehospital stage...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
Masayuki Gekka, Takeo Abumiya, Teruyuki Komatsu, Ryosuke Funaki, Kota Kurisu, Daisuke Shimbo, Masato Kawabori, Toshiya Osanai, Naoki Nakayama, Ken Kazumata, Kiyohiro Houkin
BACKGROUND AND PURPOSE: A hemoglobin-albumin cluster, 1 core of hemoglobin covalently bound with 3 shell albumins, designated as HemoAct was developed as a hemoglobin-based oxygen carrier. We aim to investigate neuroprotection by HemoAct in transient cerebral ischemia and elucidate its underlying mechanisms. METHODS: Male rats were subjected to 2-hour transient middle cerebral artery occlusion and were then administered HemoAct transarterially at the onset of reperfusion...
July 10, 2018: Stroke; a Journal of Cerebral Circulation
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