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Folia Biologica (Praha)

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https://www.readbyqxmd.com/read/28805561/kcnj11-and-kcnq1-gene-polymorphisms-are-not-associated-with-post-transplant-diabetes-mellitus-in-kidney-allograft-recipients-treated-with-tacrolimus
#1
E Dabrowska-Zamojcin, M Tarnowski, M Szydlowski, M Romanowski, V Dziedziejko, K Safranow, L Domanski, A Pawlik
Post-transplant diabetes mellitus (PTDM) is a metabolic disorder occurring after solid organ transplantation during the therapy with calcineurin inhibitors. ATP-sensitive potassium channels KCNJ11 and KCNQ1 play an important role in the regulation of insulin secretion by β cells and development of diabetes mellitus. Numerous studies have confirmed the association between KCNJ11 and KCNQ1 gene polymorphisms and type 2 diabetes. The aim of this study was to examine the association between KCNJ11 and KCNQ1 gene polymorphisms and posttransplant diabetes mellitus in kidney allograft recipients treated with tacrolimus...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28805560/glycation-of-matrix-proteins-in-the-artery-inhibits-migration-of-smooth-muscle-cells-from-the-media-to-the-intima
#2
A Kuzan, O Michel, A Gamian
Formation and growth of atherosclerotic plaques have serious clinical consequences. One mechanism that occurs during atherogenesis is migration of smooth muscle cells from the middle layer of the artery to the intima, where they proliferate and are transformed into foam cells. This degenerative process is accompanied by glycation, by which proteins are modified and change the biomechanical and biochemical properties. The aim of the study was to determine whether glycation of collagen and elastin building the walls of blood vessels alters the adhesion and rate of myocyte migration...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28805559/effect-of-stress-on-the-expression-of-galanin-receptors-in-rat-heart
#3
J Šípková, P Šída, N Kaspříková, I Kramáriková, S Hynie, V Klenerová
Neuropeptide galanin, galanin-like peptide and galanin receptors 1, 2 and 3 are a crucial part of the so-called galaninergic system. Our previous studies have shown the possible role of this system in mood modulation, especially regarding stress. So far, the galanin receptors have been found in different tissues including brain and heart. Our study deals with changes in expression of galanin receptor subtypes in the heart of Wistar rats exposed to three different types of stress. Galanin receptor subtypes were determined in fluorescently labelled samples using specific primary antibodies, and all sections were analysed in an immunofluorescent microscope and microphotographs...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28805558/oxytocin-modulates-expression-of-neuron-and-glial-markers-in-the-rat-hippocampus
#4
T Havránek, Z Lešťanová, B Mravec, V Štrbák, J Bakoš, Z Bačová
Neuropeptides including oxytocin belong to the group of factors that may play a role in the control of neuronal cell survival, proliferation and differentiation. The aim of the present study was to investigate potential contribution of oxytocin to neuronal differentiation by measuring gene and protein expression of specific neuron and glial markers in the brain. Neonatal and adult oxytocin administration was used to reveal developmental and/or acute effects of oxytocin in Wistar rats. Gene and protein expression of neuron-specific enolase (NSE) in the hippocampus was increased in 21-day and 2-month old rats in response to neonatal oxytocin administration...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28805557/microglia-physiological-functions-revealed-through-morphological-profiles
#5
K Cho, G-E Choi
Microglia play key immunological roles in the central nervous system. Upon activation, resident microglial cells transform from a ramified form to an amoeboid form and acquire the ability to phagocytose and release pro-inflammatory cytokines. Here, we review microglial phenotypes that contribute to their functional roles in the central nervous system with the emphasis on their molecular profiles. Deeper understanding of the functions performed by microglia in physiological and pathological conditions can promote investigation of microglia activities in brain injury or disease and facilitate development of new treatment approaches...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28557709/influence-of-cytochrome-p450-abc-and-slc-gene-polymorphisms-on-imatinib-therapy-outcome-of-patients-with-gastrointestinal-stromal-tumours-gist
#6
K Wasielewski, B Wasag, A Wozniak, J Pikiel, A Kowalik, C Osuch, E Bylina, J A Siedlecki, P Rutkowski, J Limon
The efficacy of imatinib-based therapy depends on the proteins involved in its metabolism and transportation. Therefore, the aim of our study was to investigate the possible correlation of selected P450, ABC and SLC polymorphic variants and the outcome of imatinib therapy. A total of 101 patients with advanced, KIT/PDGFRA(+) GIST treated with imatinib were enrolled to the study. DNA was extracted from peripheral blood samples and genotypes were determined by PCR-RFLP and direct sequencing. Deviation from the Hardy-Weinberg equilibrium was only observed for rs2740574...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28557708/spontaneously-hypertensive-rat-chromosome-2-with-mutant-connexin-50-triggers-divergent-effects-on-metabolic-syndrome-components
#7
O Šeda, D Křenová, L Šedová, L Kazdová, M Krupková, B Chylíková, F Liška, V Křen
Metabolic syndrome is a frequent condition with multifactorial aetiology. Previous studies indicated the presence of genetic determinants of metabolic syndrome components on rat chromosome 2 (RNO2) and syntenic regions of the human genome. Our aim was to further explore these findings using novel rat models. We derived the BN-Dca and BN-Lx.Dca congenic strains by introgression of a limited RNO2 region from a spontaneously hypertensive rat strain carrying a mutation in the Gja8 gene (SHR-Dca, dominant cataract) into the genomic background of Brown Norway strain and congenic strain BN-Lx, respectively...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28557707/novel-mutation-t273r-in-thyroid-hormone-receptor-%C3%AE-gene-provides-further-insight-into-cryptic-negative-regulation-by-thyroid-hormone
#8
F Kaššák, V Hána, V Saudek, M Kostrouchová
Production of thyroid hormone is precisely regulated in a negative feed-back mechanism that depends critically on thyroid hormone receptor β (TRβ). This mechanism decreases production of thyrotropin- releasing hormone (TRH) and thyrotropin (TSH) in the hypothalamus and pituitary gland in response to high levels of circulating thyroid hormones (TH). Despite the wealth of accumulated knowledge, it is still not clear how exactly this negative regulation is executed. The syndrome of resistance to thyroid hormone (RTH), in which the levels of TH are not properly sensed, represents naturally occurring situations in which molecular components of this regulation are displayed and may be uncovered...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28557706/downregulation-of-p68-rna-helicase-ddx5-activates-a-survival-pathway-involving-mtor-and-mdm2-signals
#9
M Kokolo, M Bach-Elias
The DEAD box p68 RNA helicase (DDX5) is required to manipulate RNA structures implicated in mRNA/rRNA processing and transcript export, and acts as a co-activator for a range of transcription factors. Previous research has indicated that p68 RNA helicase may also be important in tumour development. Wild-type HeLa and stable HeLa (clone 13) cell cultures containing RNAi-mediated depletion of p68 RNA helicase induced by doxycycline (DOX) were used to study how the p68 RNA helicase affects the mTOR cell signalling pathway...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28557705/moringa-olifeira-lam-stimulates-activation-of-the-insulin-dependent-akt-pathway-antidiabetic-effect-in-a-diet-induced-obesity-dio-mouse-model
#10
E S Attakpa, M M Sangaré, G J Béhanzin, J-M Ategbo, B Seri, N A Khan
We investigated the antidiabetic effect of Moringa olifeira Lam. in a diet-induced obesity (DIO) mouse model. Six mice were randomly selected as normal controls. Moringa olifeira Lam. leaf extract at a dose of 200, 400 or 600 mg/kg body weight, glibenclamide (Glib) at the dose of 10 mg/kg (positive control) and distilled water at 10 ml/kg (control group) were administered orally by gastric intubation, and each group consisted of six mice. Insulinsensitive tissues (liver, skeletal muscle) were collected to investigate antidiabetic effects and examine the plant's molecular mechanisms...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28557704/putative-effects-of-sex-hormones-on-urinary-tract-infection
#11
T Brachtlová, R Gardlík, L Tóthová
Urinary tract infections affect mostly females. The infection and possible consequent ascent of bacteria is enhanced by various risk factors. Sex hormones regulate gene transcription implicated in immune cell development and maturation, in regulation of immune responses and immune signalling pathways. Limited knowledge is available; however, recent findings underline the importance of understanding the interactions between sex hormones and urinary tract infection to diminish the occurrence of complications related to this infection...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28374673/the-influence-of-sodium-fluoride-on-the-growth-of-ameloblasts-and-kidney-proximal-tubular-cells
#12
S Wahluyo, K Ismiyatin, B Purwanto, I S Mukono
Fluoride has toxic potential particularly for teeth, bones, and kidney. This study was aimed to investigate the NaF exposure effects on the growth of ameloblasts and kidney proximal tubular cells. Adult male healthy rats were used as experiment models, divided into control and NaF-induced groups. The expression of amelogenin, Bcl-2, and caspase-3 were significantly different in the control and NaF-induced group (P < 0.05). There was no correlation among these proteins in the control group but significant correlation in the NaF-induced group (r = 0...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28374672/a-mutation-of-the-prdm9-mouse-hybrid-sterility-gene-carried-by-a-transgene
#13
O Mihola, Z Trachtulec
PRDM9 is a protein with histone-3-methyltransferase activity, which specifies the sites of meiotic recombination in mammals. Deficiency of the Prdm9 gene in the laboratory mouse results in complete arrest of the meiotic prophase of both sexes. Moreover, the combination of certain PRDM9 alleles from different mouse subspecies causes hybrid sterility, e.g., the male-specific meiotic arrest found in the (PWD/Ph × C57BL/6J)F1 animals. The fertility of all these mice can be rescued using a Prdm9-containing transgene...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28374671/gelatinases-a-and-b-and-antioxidant-enzyme-activity-in-the-early-phase-of-acute-myocardial-infarction
#14
K Gopcevic, B Rovcanin, D Kekic, D Milasinovic, G Kocic, I Stojanovic
Oxidative stress plays important roles in the pathophysiology of acute myocardial infarction (AMI). The aim of this study was to investigate the correlation of the oxidative stress status and matrix metalloproteinase activity in AMI patients in comparison to controls. This study included 136 subjects: 68 patients with AMI (42 males/26 females; mean age 58.5 ± 10.5 years) and 68 controls (37 males/29 females; mean age 60.2 ± 12.4 years). Gelatinases A and B were assayed using gelatin zymography, enzyme activities were obtained spectrophotometrically...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28374670/the-effect-of-ibuprofen-on-cytokine-production-by-mononuclear-cells-from-schizophrenic-patients
#15
H Bessler, D Cohen-Terica, M Djaldetti, P Sirota
The existence of a restrained inflammatory state in schizophrenic individuals posed the question whether anti-inflammatory drugs may exert antipsychotic effects. Therefore, the effect of ibuprofen (IB) on cytokine production by human peripheral blood mononuclear cells (PBMC) from schizophrenic patients was examined and compared to that of healthy subjects. PBMC from 25 schizophrenic patients and 24 healthy volunteers were incubated for 24 h with lipopolysaccharide (LPS) in the absence or presence of various concentrations of IB...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28374669/dynamics-of-lamins-b-and-a-c-and-nucleoporin-nup160-during-meiotic-maturation-in-mouse-oocytes
#16
V Nikolova, S Delimitreva, I Chakarova, R Zhivkova, V Hadzhinesheva, M Markova
This study was aimed at elucidating the fate of three important nuclear envelope components - lamins B and A/C and nucleoporin Nup160, during meiotic maturation of mouse oocytes. These proteins were localized by epifluorescence and confocal microscopy using specific antibodies in oocytes at different stages from prophase I (germinal vesicle) to metaphase II. In immature germinal vesicle oocytes, all three proteins were detected at the nuclear periphery. In metaphase I and metaphase II, lamin B co-localized with the meiotic spindle, lamin A/C was found in a diffuse halo surrounding the spindle and to a lesser degree throughout the cytoplasm, and Nup160 was concentrated to the spindle poles...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28374668/morphometric-and-densitometric-analysis-of-heterochromatin-during-cell-differentiation-using-the-leukaemic-granulocytic-lineage-as-a-convenient-model
#17
K Smetana, D Mikulenková, H Klamová
Granulocytic early progenitors and terminally differentiated - mature granulocytes with segmented nuclei were studied using computer-assisted diameter and heterochromatin optical image densitometry to provide more information on the nuclear size and heterochromatin condensation state. Bone marrow smears of patients suffering from chronic myeloid leukaemia untreated as well as treated with "specific" anti-leukaemic therapy with imatinib mesylate are a convenient model for such study because they possess a satisfactory number of cells for diameter and optical density measurements...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28189150/evaluation-of-epidermal-neural-crest-stem-cells-in-organotypic-spinal-cord-slice-culture-platform
#18
S Pandamooz, M S Salehi, M Nabiuni, L Dargahi, M Pourghasem
Among various strategies employed for spinal cord injury, stem cell therapy is a potential treatment. So far, a variety of stem cells have been evaluated in animal models and humans with spinal cord injury, and epidermal neural crest stem cells represent one of the attractive types in this area. Although these multipotent stem cells have been assessed in several spinal cord injury models by independent laboratories, extensive work remains to be done to ascertain whether these cells can safely improve the outcome following human spinal cord injury...
2016: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28189149/comparison-of-plasma-osteopontin-levels-between-patients-with-borderline-ovarian-tumours-and-serous-ovarian-carcinoma
#19
COMPARATIVE STUDY
J H Živný, S Leahomschi, P Klener, J Živný, M Haluzík, D Cibula
Osteopontin (OPN) is a novel biomarker of various cancers including ovarian carcinoma. OPN is a promising adjunct to a major biomarker of ovarian cancer, CA125, in diagnosis, differential diagnosis and prognosis. The aim of our study was to measure the plasma level of OPN and CA125 in patients with borderline ovarian tumours (BOTs), serous ovarian carcinoma, and controls to determine its potential role in the differential diagnosis between serous ovarian carcinoma and BOT. The plasma samples of 66 women were analysed using Luminex technology, designed to simultaneously measure multiple specific protein targets...
2016: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28189148/anxiety-and-hyperlocomotion-induced-by-chronic-unpredictable-mild-stress-can-be-moderated-with-melatonin-treatment
#20
N Spasojevic, B Stefanovic, P Jovanovic, S Dronjak
Preclinical studies have shown that melatonin exercised antidepressant-like and anxiolyticlike effects in animal models of anxiety. The aim of the present study was to correlate the changes in behaviour induced by melatonin treatment with the activity of the dopaminergic system in the hippocampus of Wistar rats exposed to chronic, unpredictable, mild stress (CUMS). Male Wistar rats, 11 weeks old, were subjected to chronic stress for 28 successive days. Separate groups of control and stressed rats were intraperitoneally injected daily either with melatonin (10 mg/kg/day, i...
2016: Folia Biologica (Praha)
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