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Indian Journal of Experimental Biology

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https://www.readbyqxmd.com/read/30084568/effect-of-ethanolic-extract-of-cyperus-rotundus-l-against-isoprenaline-induced-cardiotoxicity
#1
Sadiya Khwaja, Tarique Mahmood, Hefazat H Siddiqui
Interruption of blood supply to the heart results in acute myocardial infarction (AMI), and further damages the heart muscles. Available drugs for the treatment MI have one or other side effects, and there is a need for development of better alternative drugs from herbal sources. Here, we evaluated cardioprotective effect of Cyperus rotundus on isoprenaline- induced myocardial infarction. Thirty five Wistar rats, aged 60-100 days with body wt. 150-200 g, pretreated with ethanolic extract of Cyperus rotundus L...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084567/effect-of-ethanolic-extract-of-zingiber-officinale-roscoe-on-central-nervous-system-activity-in-mice
#2
Pradeep Kumar Sharma, Vijender Singh, Mohammad Ali, Sokindra Kumar
Zingiber officinale Roscoe, commonly known as ginger, is a traditional herb used to treat various disorders. In this study, we evaluated potential pharmacological effects of ethanolic extracts of Z. Officinale with respect to central nervous system (CNS) activity in mice. Role of ethanolic extract of ginger on CNS activity in mice was studied using models of elevated plus maze test, barbiturate-induced sleeping time, tail suspension test, hot-plate and tail-flick test. Ginger extract was administered to mice at single doses of 50 and 200 mg/kg, perorally while diazepam (1 mg/kg), morphine (5 mg/kg) and imipramine (30 mg/kg) intraperitoneally were used as standard drugs...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084566/immunostimulatory-and-growth-promoting-potential-of-tinospora-cordifolia-thunb-miers-on-fingerlings-of-amur-carp
#3
Anita, Maneesh Kumar Dubey, Akansha Khati, R S Chauhan
The enhancement of immunity of fish through application of natural immunostimulants would help in minimizing the risk of occurrence of diseases in aquaculture. The present study was designed to evaluate the growth promoting and immunostimulatory effect of Guduchi, Tinospora cordifolia (Thunb.) Miers ex Hook F. leaf powder in fingerlings of Amur carp (Cyprinus carpio haeYnatopterus Martens). The fingerlings were divided into four treatment groups, Ti, T2, T₃ and T₄. Experimental diets were prepared by mixing rice bran, deoiled mustard cake, soybean meal and vitamin mineral mixture...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084565/carissa-congesta-wight-and-benincasa-hispida-thunb-cogn-as-budding-immunomodulatory-agents
#4
Hemant Devidas Une, Gaurav Mahesh Doshi
Carissa congesta and Benincasa hispida are well-known medicinally important plants associated with diabetes, inflammation, protozal infections and cancer. Here, we emphasized up on the immunomodulatory potential of these plants as the source of lupeol, P-sitosterol and ursolic acid. Petroleum ether extracts of C. congesta roots and B. hispida seeds were subjected to acute toxicity studies. They were screened for its immunomodulatory prospective in rats by Haemagglutination Antibody (HA) titre and Delayed-Type Hypersensitivity (DTH) response using Sheep Red Blood Cells (SRBCs of-0...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084564/neurospora-sp-sr8-a-novel-phosphate-solubiliser-from-rhizosphere-soil-of-sorghum-in-kachchh-gujarat-india
#5
Seema B Sharma, Riyaz Z Sayyed, Mahesh Sonawane, Mrugesh H Trivedi, Gobi A Thivakaran
Phosphorus (P) is abundant in soils in both inorganic and organic forms; nevertheless, it is unavailable to plants due to its fixation. Phosphate solubilising microorganisms including fungi play a pivotal role in making P available for plants by the process of solubilisation and mineralisation. Among the fungi that solubilize phosphate, the genera Aspergillus and Penicillium are the most representative although strains of Trichoderma and Rhizoctonia solani have also been reported as P solubilizers. Here, we report Neurospora discreta strain SR8 (NCCS Pune accession No...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084563/optimization-of-growth-conditions-and-medium-composition-for-improved-conidiation-of-newly-isolated-beauveria-bassiana-strains
#6
Sushant Dhar, Vikas Jindal, V K Gupta
Beauveria bassiana is an entomopathogenic fungus with high potential in controlling insect pests. In this study, we propose optimum cultural conditions and culture media for better growth of various B. bassiana strains. B. bassiana strains achieved their maximum growth during optimal incubation period of seven days. The optimum pH and temperature for maximal growth of B. bassiana strains was found to be 6-7 and 25-30⁰C, respectively. All the tested carbon and nitrogen sources supported growth and development of the B...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084562/maturation-timing-and-fetal-bovine-serum-concentration-for-developmental-potential-of-sheep-oocytes-in-vitro
#7
Ashish Mishra, P S P Gupta, V Sejian, I J Reddy, J P Ravindra
The success of in vitro embryo production (IVEP) in animals has improved over time, employing a variety of culture media. Here, we assessed the maturation timing and developmental potential of sheep oocytes in vitro at different concentrations of fetal bovine serum (FBS): Cumulus oocyte complexes (COCs) were aspirated from follicles (2-6 mm) of sheep ovaries collected from local slaughter house. COCs were randomly divided into two groups and matured at 38.5'C, 5% CO2 for 24 h (Group I) and 27 h (Group II). Oocytes cultured for 27 h showed significantly (P <0...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/30084561/breast-cancer-role-of-igf-1-and-igfbp-3-expression-in-prognostication
#8
Apexa Raval, Sunil Trivedi
Deregulation of Insulin like growth factors (IGF) is an>important determinant of breast carcinogenesis. Circulatory IGF-1 (potent breast mitogen) and IGFBP-3 (its regulator) are exteisively evaluated; few studies report transcript copy numbers.(CN) from ex-vivo samples. This study from 106 patients evaluated mRNA expression (qRT-PCR CN) of IGF-1 and IGFBP-3 for prognostic and predictive utility from tumor, adjacent normal tissues (ANT) and lymph nodes. The differences in.IGF-1 and IGFBP-3 mRNA levels (CN/μg RNA) were juxtaposed to clinical and pathologic variables and survival...
October 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699727/assessment-of-prophylactic-effect-of-senna-auriculata-l-roxb-leaves-on-alcohol-induced-pancreatitis-in-rat-model
#9
Gaurav Gupta, Suman Bala Sharma, Richa Gupta, Shipra Gupta, Usha Rani Singh
Aqueous leaf extract of Senna auriculata (L.) Roxb. syn. Cassia auriculata (SLEx) is known to possess potential antidiabetic and antioxidant properties. Based on the known correlation between exocrine pancreatic function and endocrine secretary capacity, here, we studied the prophylactic effect of the SLEx on alcohol induced pancreatitis in rats. To induce chronic pancreatitis, the rats were fed with unsaturated fat i.e. corn oil (2.5 mL/kg) along with high dose of ethanol (10.2 g/kg) for 4 wk, and was increased 0...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699726/in-vitro-digestibility-study-of-some-plant-protein-sources-as-aquafeed-for-carps-labeo-rohita-and-cyprinus-carpio-using-ph-stat-method
#10
Jai Gopal Sharma, Ashok Kumar, Deepak Saini, Nawang Lendup Targay, Bronson Kumar Khangembam, Rina Chakrabarti
Aquaculture, as a promising food industry, is expected to meet the demand for quality food from the increasing human population. As the diet is critical for feeding farm fish, such a faster growth in the industry is destined to create stress in the fishmeal market to supply diets to the tune. In this context, here, we studied the protein content of 20 plant ingredients, including aquatic weeds, cereals, pulses and oil-cakes using micro-Kjeldahl method and evaluated in vitro digestibility of these ingredients for rohu Labeo rohita and common carp Cyprinus carpio using pH-Stat method...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699725/evaluation-of-candidate-reference-genes-for-quantitative-expression-studies-in-asian-seabass-lates-calcarifer-during-ontogenesis-and-in-tissues-of-healthy-and-infected-fishes
#11
Anutosh Paria, Jie Dong, P P Suresh Babu, M Makesh, Aparna Chaudhari, A R Thirunavukkarasu, C S Purushothaman, K V Rajendran
Quantitative real-time PCR (qRT-PCR), used to determine the gene expression profile, is an important tool in functional genomic research, including fishes. To obtain more robust and meaningful result, the best possible normalization of the data is of utmost significance. In the present study, we have evaluated the potential of five commonly used housekeeping genes i.e., elongation factor 1-α (EF1A), β-Actin (ACTB), 18S ribosomal RNA (18S), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-2-Microglobulin (B2M) in normal physiological conditions, developmental stages and in response to bacterial infection in Asian seabass, Lates calcarifer (Bloch), an important food fish cultured in the Asia-Pacific region...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699724/toxicity-of-bacillus-thuringiensis-cry2ab-and-the-inheritance-of-cry2ab-resistance-in-the-pink-bollworm-pectinophora-gossypiella-saunders
#12
P A Malthankar, G T Gujar
Though the insecticidal crystal (Cry) proteins produced by Bacillus thuringiensis (Bt) are effective against insect pests, evolution of resistance remains an issue of great concern. Here, we explored the ability of pink bollworm, Pectinophora gossypiella (Lepidoptera: Gelechiidae), a key pest of cotton, to evolve resistance to Cry2Ab and characterized it in terms of inheritance. Sixteen day bioassay of Bt Cry2Ab toxin against 5-day old pink bollworm larvae showed median lethal concentration (LC(50)) ranging 0...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699723/fermentation-isolation-purification-and-characterization-of-an-antitubercular-antibiotic-from-streptomyces-luridus-mtcc-4402
#13
S Anuradha, K Shravan Kumar, S Bhama, V Kishan
Tuberculosis, caused by Mycobacterium tuberculosis, continues to be a serious public health problem around the world, and it urges the need for development of new antitubercular drugs. An antibiotic producing strain, Streptomyces luridus (MTCC 4402) was earlier isolated from soil by our group. In this work, the phylogenic status was established by 16S rRNA gene sequence analysis. The strain was found to be active against clinically resistant strains. The culture was grown in shake flasks in a medium containing cornsteep liquor, glucose, CaCO(3), soyabean meal and starch...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699722/antinociceptive-anti-inflammatory-and-antiarthritic-activities-of-bungarus-fasciatus-venom-in-experimental-animal-models
#14
Susmita Ghosh, Partha Pratim Saha, Subir C Dasgupta, Antony Gomes
Pain and inflammation are intimately associated with rheumatoid arthritis, a growing bone-joint related problem of the modern society. Though several therapeutic managements are available for arthritis, their side effects not only limit their use, but also advocate the quest for natural therapies. In this study, we explored the antinociceptive, anti-inflammatory and antiarthritic activities of Bungarus fasciatus venom (BFV) in experimental animal models. Rheumatoid arthritis was induced by Freund’s complete adjuvant (FCA) in male Wistar albino rats...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699721/comparison-of-pre-and-post-ischemic-treatment-of-telmisartan-and-nimodipine-combination-in-experimentally-induced-cerebral-ischemia
#15
(no author information available yet)
Time dependent intervention plays a crucial role in preventing neurodegeneration after ischemic insult. The intensity of excitotoxicity is greater in the secondary reperfusion phase (2-4 h) compared to the primary occlusion phase (2 h), which could be attributed to secondary elevation of excitatory amino acids (EAA) in cerebral ischemia. In the present study, we tried to assess the neuroprotective effects of telmisartan and nimodipine (TM-NM) combination on the secondary reperfusion phase. The drug treatments were made immediately after reperfusion and their effects were compared with pre-treatment...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699720/in-vitro-cytotoxic-activity-evaluation-of-phenytoin-derivatives-against-human-leukemia-cells
#16
Katarzyna Śladowska, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Lidia Mazur
Hydantoin derivatives, including phenytoin (5,5-diphenylhydantoin), have recently gained attention as they possess a variety of important biochemical and pharmacological properties. Nevertheless, available information on anticancer activity of hydantoin derivatives is still scarce. Here, we evaluated possible antileukemic potential of four phenytoin analogs, namely: methyl 2-(2,4-dioxo-5,5-diphenylimidazolidin-3-yl)propanoate (1), methyl 2-(1-(3-bromopropyl)-2,4-dioxo-5,5-diphenylimidazolidin-3-yl)propanoate (2), 1-(3-bromopropyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione (3) and 1-(3-bromobutyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione (4)...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28577518/development-of-transgenic-pigeonpea-cajanus-cajan-l-millsp-overexpressing-citrate-synthase-gene-for-high-phosphorus-uptake
#17
Aftab Aftab Hussain, I S Pavithra, Rohini Sreevathsa, K N Nataraja, Naveen Babu
Plants have developed several adaptive strategies to enhance the availability and uptake of phosphorus (P) from the soil under conditions of P deficiency. Exudation of organic acids like citrate is one of the important strategies. In this study, we developed transgenic pigeonpea (Cajanus cajan) over-expressing Dacus carota citrate synthase (DcCs) gene to increase the synthesis and exudation of citrate. Transgenic plants were generated through agro bacterium mediated in-planta transformation technique. Integration and expression of the transgene was confirmed by genomic Southern and RT-PCR analysis...
August 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28577517/genotoxicity-in-lead-treated-human-lymphocytes-evaluated-by-micronucleus-and-comet-assays
#18
Ankita J Shah, B C Lakkad, Mandava V Rao
Lead (Pb) which plays a significant role in modern industry is related to a broad range of physiological, biochemical, behavioural and genetical dysfunctions. Its exposure leads to an increased frequency of genetic aberrations in humans. Hence, this study was designed to assess the genotoxic effect of lead acetate at three dosage levels (10, 25 and 50 µg/mL) by employing: the Cytokinesis Block Micronucleus (CBMN) assay and the Comet assay in Peripheral Blood Lymphocyte Cultures. The results of this study revealed an increased level of DNA damage among treated groups...
August 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28577516/improvement-of-bacillus-strains-by-mutation-for-overproduction-of-exopolygalacturonases
#19
Hira Muzzamal, Zakia Latif
Pectinases, produced by microorganisms, have wide range application in food industry, textile processing, paper making, coffee and tea fermentation, etc. It accounts for 10% of the global industrial enzymes produced. The most important and widely used commercial pectinase polygalacturonase is produced by alkalophilic strains of Bacillus sp. and Streptomyces sp. Here, we explored 29 bacterial strains isolated from rotten mango samples for polygalacturonase production and selected 16 strains through preliminary screening by well-plate method for enzyme activity...
August 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28577515/glycoside-hydrolase-production-by-aspergillus-terreus-cm20-using-mixture-design-approach-for-enhanced-enzymatic-saccharification-of-alkali-pretreated-paddy-straw
#20
M Saritha, Rameshwar Tiwari, Surender Singh, Pawan K S Nain, Sarika Rana, Anurup Adak, Anju Arora, Lata Nain
A successful lignocellulosic ethanol production process needs to address the technological impediments such as cost-competitiveness and sustainability of the process. Effective biomass utilization requires a repertoire of enzymes including various accessory enzymes. Developing an enzyme preparation with defined hydrolytic activities can circumvent the need for supplementing cellulases with accessory enzymes for enhanced hydrolysis. With this objective, mixture design approach was used in the present study to enhance glycoside hydrolase production of a fungal isolate, Aspergillus terreus CM20, by determining the proportion of different lignocellulosic components as enzyme inducers in the culture medium...
August 2016: Indian Journal of Experimental Biology
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