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Chemico-biological Interactions

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https://www.readbyqxmd.com/read/28342890/vasodilatory-effect-of-nitroglycerin-in-japanese-subjects-with-different-aldehyde-dehydrogenase-2-aldh2-genotypes
#1
Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Kazuya Yonezawa
The functional genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) influences the enzymatic activities of its wild type (Glu504 encoded by ALDH2*1) and mutant type (Lys504 encoded by ALDH2*2) proteins. The enzymatic activities of mutant-type ALDH2 are limited compared with those of the wild type. ALDH2 has been suggested as a critical factor for nitroglycerin-mediated vasodilation by some human studies and in vitro studies. Currently, there is no research on direct observations of the vasodilatory effect of nitroglycerin sublingual tablets, which is the generally used dosage form...
March 23, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28342889/heteromeric-complexes-of-aldo-keto-reductase-auxiliary-kv%C3%AE-subunits-akr6a-regulate-sarcolemmal-localization-of-kv1-5-in-coronary-arterial-myocytes
#2
Matthew A Nystoriak, Deqing Zhang, Ganapathy Jagatheesan, Aruni Bhatnagar
Redox-sensitive potassium channels consisting of the voltage-gated K(+) (KV) channel pore subunit KV1.5 regulate resting membrane potential and thereby contractility of vascular smooth muscle cells. Members of the KV1 family associate with cytosolic auxiliary β subunits, which are members of the aldo-keto reductase (AKR) superfamily (AKR6A subfamily). The Kvβ subunits have been proposed to regulate Kv1 gating via pyridine nucleotide cofactor binding. However, the molecular identity of KVβ subunits that associate with native KV1...
March 22, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28342888/effect-of-exogenous-tgf-%C3%AE-1-on-the-cadmium-induced-nephrotoxicity-by-inhibiting-apoptosis-of-proximal-tubular-cells-through-pi3k-akt-mtor-signaling-pathway
#3
Minyi Huang, Li Su, Limin Yang, Liangliang Zhu, Zhaowen Liu, Renyan Duan
Heavy metal polluted soils have been a serious problem for the global ecological balance and people's health. Cadmium (Cd), one of the heavy metals, could induce apoptosis of proximal tubular cells in many experimental models and lead to damage the human kidney. Here, we reported a potent chemokine TGF-β1 which could ameliorate cadmium-induced nephrotoxicity. Interestingly, western blotting and TUNEL staining assays indicated that PI3K-AKT-mTOR signaling pathway was involved in the protective mechanism of TGF-β1 in vitro and in vivo...
March 22, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28322779/semisynthetic-oleanane-triterpenoids-inhibit-migration-and-invasion-of-human-breast-cancer-cells-through-downregulated-expression-of-the-itgb1-ptk2-pxn-pathway
#4
Natalia Lisiak, Anna Paszel-Jaworska, Ewa Totoń, Błażej Rubiś, Martyna Pakuła, Barbara Bednarczyk-Cwynar, Lucjusz Zaprutko, Maria Rybczyńska
This paper reports a study on the role of two synthetic derivatives of oleanolic acid (OA), HIMOXOL and Br-HIMOLID, in the regulation of cell migration and invasion and the underlying molecular mechanisms of breast cancer cells. The effect of the compounds on four breast cancer cell lines (MCF7, MDA-MB-231, MDA-MB-468, and T-47D) and also on noncancerous breast cells, MCF-12A, was reported. The compounds had no effect on the migration of MCF-12A cells. However, both the derivatives revealed a higher cytotoxicity than the maternal compound OA, and in sub-cytotoxic concentrations, they decreased the migration of MCF7, MDA-MB-231, and MDA-MB-468 breast cancer cells and also the invasion of MCF7 and MDA-MB-231 cells; although, the derivatives had no effect on the migration and invasion of T-47D cells...
March 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28322778/down-regulation-of-cyclin-dependent-kinase-4-and-mapk-through-estrogen-receptor-mediated-cell-cycle-arrest-in-human-breast-cancer-induced-by-gold-nanoparticle-tagged-toxin-protein-nkct1
#5
Tanmoy Bhowmik, Antony Gomes
AIM: The aim of this study was to determine whether gold nanoparticles conjugated cytotoxic protein NKCT1 (GNP-NKCT1) acted through the estrogen receptor mediated pathway in MCF-7 cells and to establish the MAPK and PI3k/Akt signal transduction pathway. METHODS: Apoptosis was done by flow cytometry. BrdU incorporation and nuclear proliferating antigen was measured by flow cytometry. Wound healing assay along with matrigel chamber invasion and migration was done...
March 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28322781/characterization-of-akr1b16-a-novel-mouse-aldo-keto-reductase
#6
Joan Giménez-Dejoz, Susanne Weber, Oleg A Barski, Gabriele Möller, Jerzy Adamski, Xavier Parés, Sergio Porté, Jaume Farrés
Aldo-keto reductases (AKRs) are distributed in three families and multiple subfamilies in mammals. The mouse Akr1b3 gene is clearly orthologous to human AKR1B1, both coding for aldose reductase, and their gene products show similar tissue distribution, regulation by osmotic stress and kinetic properties. In contrast, no unambiguous orthologs of human AKR1B10 and AKR1B15.1 have been identified in rodents. Although two more AKRs, AKR1B7 and AKR1B8, have been identified and characterized in mouse, none of them seems to exhibit properties similar to the human AKRs...
March 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28322780/reductive-metabolism-of-tiaprofenic-acid-by-the-human-liver-and-recombinant-carbonyl-reducing-enzymes
#7
Petra Malátková, Adam Skarka, Kateřina Musilová, Vladimír Wsól
Tiaprofenic acid is a widely used anti-inflammatory drug; however, the reductive metabolism of tiaprofenic acid is not yet well understood. Here, we compared the reduction of tiaprofenic acid in microsomes and cytosol from the human liver. The microsomes exhibited lower Km value toward tiaprofenic acid than the cytosol (Km = 164 ± 18 μM vs. 569 ± 74 μM, respectively), whereas the cytosol showed higher specific activity during reduction than the microsomes (Vmax = 728 ± 52 pmol mg of protein(-1)·min(-1) vs...
March 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28284660/itraq-based-quantitative-proteomics-discovering-potential-serum-biomarkers-in-locoweed-poisoned-rabbits
#8
Jifeng Jiao, Shuai Wang, Ruishi Zhang, Zhiyan Ma, Guofeng Du, Xiaolu Chen, Dayong Tao, Jinxiang Zhao
Locoism threatens the sustainable development of animal husbandry in areas around the world with intensified desertification, especially in the western United States, western China, Canada, and Mexico, among other countries. This study was conducted to discover potential serum biomarkers in locoweed-poisoned rabbits and lay a foundation for early diagnosis of locoism. We performed iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS), comparing locoweed-poisoned rabbits and healthy controls...
March 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28284659/diuretic-natriuretic-and-potassium-sparing-effect-of-nothofagin-isolated-from-leandra-dasytricha-a-gray-cogn-leaves-in-normotensive-and-hypertensive-rats
#9
Camila Leandra Bueno de Almeida, Thaise Boeing, Lincon Bordignon Somensi, Viviane Miranda Bispo Steimbach, Luísa Mota da Silva, Sérgio Faloni de Andrade, Franco Delle Monache, Valdir Cechinel-Filho, Priscila de Souza
Active constituents from natural origin have long been used for the treatment of patients suffering from cardiovascular and renal diseases. This study therefore aimed to investigate the diuretic and natriuretic properties of nothofagin, a dihydrochalcone isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats. Male Wistar normotensive rats were orally treated with vehicle (1 ml/kg); hydrochlorothiazide (HCTZ; 25 mg/kg); ethyl acetate fraction from L. dasytricha (EALD; 3-30 mg/kg) and nothofagin (NOT; 0...
March 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28283413/solasodine-inhibits-invasion-of-human-lung-cancer-cell-through-downregulation-of-mir-21-and-mmps-expression
#10
Kun-Hung Shen, Jui-Hsiang Hung, Chia-Wei Chang, Yu-Ting Weng, Ming-Jiuan Wu, Pin-Shern Chen
Solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant (Solanum melongena), was found to inhibit proliferation in various tumor cells. However, the effect of solasodine on cancer cell metastasis remains unclear. This study investigates the suppression mechanism of solasodine on motility of human lung cancer cell A549 in vitro. Results show that solasodine reduces viability of A549 cells. Treatment with non-toxic doses of solasodine suppresses markedly cell invasion. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), as well as tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2...
March 7, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28274720/functional-analysis-of-a-novel-repressor-luxr-in-comamonas-testosteroni
#11
Ye Ji, Tianyuan Pan, Yang Zhang, Guangming Xiong, Yuanhua Yu
Comamonas testosteroni (C. testosteroni) ATCC11996 is a gram negative bacterium which can use steroid as a carbon and energy source. 3,17β-hydroxysteroid dehydrogenase (3,17β-HSD) is a key enzyme for the degradation of steroid hormones in C. testosteroni. The LuxR regulation family is a group of regulatory proteins which play important role in gram negative bacterium. The luxr gene is located on 58 kb upstream of 3,17β-HSD gene with the opposite transcription orientation in the chromosomal DNA of C. testosteroni...
March 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28274719/kinetic-features-of-carbonyl-reductase-1-acting-on-glutathionylated-aldehydes
#12
Roberta Moschini, Rossella Rotondo, Giovanni Renzone, Francesco Balestri, Mario Cappiello, Andrea Scaloni, Umberto Mura, Antonella Del-Corso
The attempt to evaluate the human carbonyl reductase 1 (CBR1) activity on 3-glutathionylated-4-hydroxyalkanals through the classical spectrophotometric assay, in which NADPH oxidation is monitored at 340 nm, failed. This was due to the ability of the enzyme to catalyze the reduction of the free aldehyde form and at the same time the oxidation of the hemiacetal structure of this class of substrates, thus leading to the occurrence of a disproportion reaction sustained by a redox recycle of the pyridine cofactor...
March 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28263721/hepatoprotective-effect-of-7-hydroxycoumarin-against-methyl-glyoxal-toxicity-via-activation-of-nrf2
#13
Dan Li, Na Wang, Jingdong Zhang, Shuren Ma, Zhuangzhuang Zhao, Elizabeth M Ellis
Methyl glyoxal (MG), a major precursor of advanced glycation end-products, has been identified as significant in the progression of several diseases including aging, diabetes and neurodegenerative diseases as well as causing hepatic damages. 7-hydroxycoumarin (7-HC), a natural-occurring derivative of coumarin from fruits and plants, has been reported to exert antioxidant and free radical-scavenging properties, protecting cells from aldehydes and oxidants. In this study, the ability of 7-HC to protect human HepG2 cells against MG-induced toxicity and oxidative stress was investigated...
March 2, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28263720/simvastatin-down-regulates-differential-genetic-profiles-produced-by-organochlorine-mixtures-in-primary-breast-cell-hmec
#14
Javier Rivero, Luis Alberto Henríquez-Hernández, Luis D Boada, Jose Pestano, Octavio P Luzardo, María Camacho, Manuel Zumbado, Pilar F Valerón
Women all over the world are exposed to an unavoidable contamination by organochlorine pesticides and other chemical pollutants. Many of them are considered as xenoestrogens and have been associated with the development and progression of breast cancer. We have demonstrated that the most prevalent pesticide mixtures found in healthy women and in women diagnosed with breast cancer modulates the gene expression in human epithelial mammary cells. Statins are well-known cholesterol-depleting agents acting as inhibitors of cholesterol synthesis...
March 2, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28259689/modulation-of-neuro-inflammatory-condition-acetylcholinesterase-and-antioxidant-levels-by-genistein-attenuates-diabetes-associated-cognitive-decline-in-mice
#15
Mithun Singh Rajput, Purnima Dey Sarkar
The association of diabetes and cognitive decline may indicate that high sugar level might be a risk factor for Alzheimer's disease. A collective term 'diabetes associated cognitive decline' (DACD) has been coined for the patients with type 2 diabetes mellitus showing decline in their cognitive function, especially weak episodic memory, cognitive inflexibility and poor psychomotor performance leading towards Alzheimer's disease. However, at present, no specific treatment exists for the prevention and/or treatment of DACD...
March 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28257955/sex-hormones-reduce-nnk-detoxification-through-inhibition-of-short-chain-dehydrogenases-reductases-and-aldo-keto-reductases-in-vitro
#16
Claudia Stapelfeld, Edmund Maser
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, nicotine-derived nitrosamine ketone) is classified as carcinogenic to humans (IARC, Group 1) and considered to play the most important role in tobacco-related lung carcinogenesis. Detoxification of NNK through carbonyl reduction is catalyzed by members of the AKR- and the SDR-superfamilies which include AKR1B10, AKR1C1, AKR1C2, AKR1C4, 11β-HSD1 and CBR1...
February 28, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28257954/effects-of-tetrahydroberberine-and-tetrahydropalmatine-on-hepatic-cytochrome-p450-expression-and-their-toxicity-in-mice
#17
Dujun Wang, Kai Wang, Danjuan Sui, Zhen Ouyang, Haiyu Xu, Yuan Wei
The aim of this study was to investigate the effects of tetrahydroberberine (THB) and tetrahydropalmatine (THP) on the expression of mouse liver cytochrome P450s, and evaluate their liver toxicity in mice. Real-time polymerase chain reaction (PCR) and western blot analyses were used to analyze the expression of major P450 isoforms. Liver toxicity was evaluated by measuring serum biochemical parameters and performing histopathological analysis. The real-time PCR results showed that THB induced Cyp1a2 (1.66 ± 0...
February 28, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28257953/zinc-related-actions-of-sublethal-levels-of-benzalkonium-chloride-potentiation-of-benzalkonium-cytotoxicity-by-zinc
#18
Tsuyoshi Mitani, Ahmed Ibrahim Elhossany Elmarhomy, Luvsandorj Dulamjav, Enkhtumur Anu, Shohei Saitoh, Shiro Ishida, Yasuo Oyama
Benzalkonium chloride (BZK) is a common preservative used in pharmaceutical and personal care products. ZnCl2 was recently reported to significantly potentiate the cytotoxicity of some biocidal compounds. In the present study, therefore, we compared the cytotoxic potency of BZK and then further studied the Zn(2+)-related actions of the most cytotoxic agent among BZK, using flow cytometric techniques with appropriate fluorescent probes in rat thymocytes. Cytotoxicity of benzylcetyldimethylammonium (BZK-C16) was more potent that those of benzyldodecyldimethylammonium and benzyldimethyltetradecylammonium...
February 28, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28254523/transcriptomic-analysis-and-plasma-metabolomics-in-aldh16a1-null-mice-reveals-a-potential-role-of-aldh16a1-in-renal-function
#19
Georgia Charkoftaki, Ying Chen, Ming Han, Monica Sandoval, Xiaoqing Yu, Hongyu Zhao, David J Orlicky, David C Thompson, Vasilis Vasiliou
ALDH16A1 is a novel member of the ALDH superfamily that is enzymatically-inactive and highly expressed in the kidney. Recent studies identified an association between a rare missense single nucleotide variant (SNV) in the ALDH16A1 gene and elevated serum uric acid levels and gout. The present study explores the mechanisms by which ALDH16A1 influences uric acid homeostasis in the kidney. We generated and validated a mouse line with global disruption of the Aldh16a1 gene through gene targeting and performed RNA-seq analyses in the kidney of wild-type (WT) and Aldh16a1 knockout (KO) mice, along with plasma metabolomics...
February 28, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28254521/biological-evaluation-of-a-halogenated-triterpenoid-2%C3%AE-bromo-dihydrobelulonic-acid-as-inhibitor-of-human-topoisomerase-ii%C3%AE-and-hela-cell-proliferation
#20
Shilpi Ghosh, Swagata Mukhopadhyay, Mrinmoy Sarkar, Amitava Mandal, Vaskar Das, Anoop Kumar, Biplab Giri
BACKGROUND: The pentacyclic lupane-type (6-6-6-6-5 type) triterpenoid, Betulinic acid (BA) is a potent inhibitor of topoisomerases and is of immense interest as anticancer drugs. However, the compound being highly lipophilic, has limited in vivo uptake capacity. BA derivatives with halogen substituent at C-2 have improved membrane permeability and cytotoxicity against cancer cells. AIM: The halogenated triterpenoid, 2α-bromo-dihydrobetulonic acid (B1) was synthesized from betulinic acid (BA) isolated from Bischofia javanica...
February 28, 2017: Chemico-biological Interactions
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