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Chemico-biological Interactions

Tzu-Chin Wu, Shu-Ting Chan, Chih-Ning Chang, Pei-Syuan Yu, Cheng-Hung Chuang, Shu-Lan Yeh
Nickel exposure promotes the invasive potential of human lung cancer cells. Polyphenols such as quercetin, curcumin, chrysin, apigenin, and luteolin, present in many plant foods may suppress the development of cancers. However, whether these compounds inhibit the promoting effects of Nickel on cancer cell invasion and migration as well as the possible mechanisms are unclear. In the present study, we first showed that quercetin, curcumin, chrysin, apigenin, and luteolin at 5 μM, significantly suppressed the promoting effects of NiCl2 (Ni) on migration and invasion in H1975 and A549 human lung cancer cells...
July 14, 2018: Chemico-biological Interactions
Jing-Wen Zhao, Chao-Yang Zheng, Hong Wei, Da-Wei Wang, Wei Zhu
The herbs with sulfur-fumigation may induce chemical transformation thus causing harmful effects on patients. In the current study, the difference of physicochemical property from sulfur-fumigated Smilax glabra Roxb. polysaccharides (SSGRP) and non-fumigated Smilax glabra Roxb. polysaccharides (NSGRP) were characterized and compared, such as external appearance, dissolvability, extraction yield, glucose content, inorganic elements analysis, UV and IR scanning spectrum. Additionally, the immunotoxicity and mechanisms of SSGRP and NSGRP on immune response of murine abdominal RAW264...
July 13, 2018: Chemico-biological Interactions
Gabriela Meireles, Michiel A Daam, Ana Letícia Madeira Sanches, Maria V B Zanoni, Amadeu M V M Soares, Carlos Gravato, Danielle P de Oliveira
Dyes have been used for more than twenty thousand years in textile, pharmaceutical, food, cosmetic, and photographic industries, among others. Despite their importance in these applications, dyes can be toxic and resistant to many degradation processes used in wastewater treatment plants. Although a large number of dyes have been released in the environments in high amounts, studies into the environmental toxicity of these substances are still scarce. The aim of this study was to evaluate the potential toxic effects of textile dyes Disperse Red 60, Disperse Red 73 and Disperse Red 78 in zebrafish early life stages...
July 10, 2018: Chemico-biological Interactions
Moshe Goldsmith, Yacov Ashani
Recent years have seen an increasing number of incidence, in which organophosphate nerve agents (OPNAs) have been used against civilians with devastating outcomes. Current medical countermeasures against OPNA intoxications are aimed at mitigating their symptoms, but are unable to effectively prevent them. In addition, they may fail to prevent the onset of a cholinergic crisis in the brain and its secondary toxic manifestations. The need for improved medical countermeasures has led to the development of bioscavengers; proteins and enzymes that may prevent intoxication by binding and inactivating OPNAs before they can reach their target organs...
July 7, 2018: Chemico-biological Interactions
Peter Takac, Martin Kello, Martina Bago Pilatova, Zuzana Kudlickova, Maria Vilkova, Pavlina Slepcikova, Peter Petik, Jan Mojzis
In the present study, we investigated antiproliferative activity of seven newly synthesized chalcone derivatives. Among tested compounds, (2 E)-3-(acridin-9-yl)-1-(2,6-dimethoxyphenyl)prop-2-en-1-one (1C) was the most potent with IC50  = 4.1 μmol/L in human colorectal HCT116 cells and was selected for further studies. Inhibition of cell proliferation was associated with cell cycle arrest in G2/M phase and dysregulation of α, α1 and β5 tubulins. Moreover, 1C caused disruption of the mitochondrial membrane potential and increased number of cells with sub G0/G1 DNA content which is considered as marker of apoptosis...
July 5, 2018: Chemico-biological Interactions
Marina Ricci, Marta Miola, Cristina Multari, Ester Borroni, Rosa Angela Canuto, Noemi Congiusta, Enrica Vernè, Antonia Follenzi, Giuliana Muzio
Breast cancer chemotherapy can cause side effects due to nonspecific drug delivery, low solubility and fast metabolism of drugs used in conventional therapy. Moreover, the therapeutic effect of the drugs is often reduced by the strengthening of chemoresistance, which occurs via a variety of mechanisms. Different strategies have been developed to reduce multidrug resistance (MDR)-associated gene expressions including the use of surfactants and polymers. In this study superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with conjugated linoleic acid (CLA) reduced the number and viability of cells in comparison with both untreated cells or cells treated with SPIONs alone...
July 3, 2018: Chemico-biological Interactions
Rania R Abdеlaziz, Mohammеd Kh Еlmahdy, Ghada M Suddеk
Asthma is a common airways inflammatory disease. This study provides evidence on the efficacy of flavocoxid against ovalbumin (OVA)-induced allergic airways inflammation in a mouse model of asthma. Airway inflammation was induced by intrapеritonеal injection of 10 mg ovalbumin (OVA) on day zero and day 7 followed by OVA challenge starting from 14th day to 16th day. Beclomethasone; a standard anti-inflammatory agent was selected as a drug in asthma. Flavocoxid (20 mg/kg, i. p.) was administered on day zero till 16th day followed by OVA challenge...
July 2, 2018: Chemico-biological Interactions
Andjelika Kalezic, Biljana Macanovic, Eliana Garalejic, Aleksandra Korac, Vesna Otasevic, Bato Korac
Nitric oxide (NO) is a signaling molecule responsible for initiation of molecular events that influence sperm functionality in a concentration-dependent manner. It is still not fully understood how seminal plasma NO contributes to sperm pathologies. The aim of this study was to elucidate whether and how NO is implicated in etiology of different sperm abnormalities. To this end we determine NO, nitrite and 3-nitrotyrosine (3-NT) content in seminal plasma of infertile men with specific pathologies (terato-, oligoterato- and oligoasthenoteratospermia) and relate it to infertile normospermic samples...
July 2, 2018: Chemico-biological Interactions
Mengzhao Zhang, Hongxia Du, Zhixin Huang, Pu Zhang, Yangyang Yue, Weiyi Wang, Wei Liu, Jin Zeng, Jianbin Ma, Guanqiu Chen, Xinyang Wang, Jinhai Fan
BACKGROUND: Thymoquinone (TQ), the major active compound isolated from black seed oil (Nigella sativa), has been reported to exhibit anti-inflammatory and anticancer abilities. However, the exact molecular mechanism underlying the anticancer effect of TQ is still poorly understood, especially in regard to TQ's effect on endoplasmic reticulum stress-mediated apoptosis. METHODS: The cytotoxicity of TQ on T24 and 253J bladder cancer cells was analyzed by MTT assay, colony formation assay and Annexin V-FITC/PI staining, while SV-HUC-1, the SV-40 immortalized human uroepithelial cell line, was used as a normal control...
July 2, 2018: Chemico-biological Interactions
L C Cruz, A Ecker, N R Rodrigues, I K Martins, T Posser, F E Maciel, M A Vargas, N V Barbosa, J L Franco
We conducted an investigation to evaluate the effects of Brazilian Pampa biome honey and its major phenolic compounds on the development of an erected wings posture phenotype and related mitochondrial aspects induced by Hypoxia/Reoxygenation (H/R) in Drosophila melanogaster. Flies were pre-treated for 3 days with a 10% honey solution and different concentrations of caffeic acid and ρ-coumaric acid and then submitted to hypoxia for 3 h. We observed that after reoxygenation, some flies acquired an erected wings posture and that this feature may be related to mortality...
June 28, 2018: Chemico-biological Interactions
Deniz Ozkan Vardar, Sevtap Aydin, Ibrahim Hocaoglu, Funda Havva Yagci Acar, Nursen Basaran
Quantum dots (QDs) are highly promising nanomaterials in bioimaging system because of their bright fluorescence, broad UV excitation, narrow emission band, and high photostability. Recently, there is a great activity on Ag2 S quantum dots for both imaging and drug/gene delivery due to the potential of having a better cytocompatability and near infrared luminescence. 2-Mercaptopropionic acid (2 MP A)-coated silver sulfide (Ag2 S) QDs were reported as the most luminescent, stable, anionic Ag2 S QDs in the literature...
June 26, 2018: Chemico-biological Interactions
Artur Christian Garcia da Silva, Adrienny Rodrigues Chialchia, Renato Ivan de Ávila, Marize Campos Valadares
Eye toxicity is a mandatory parameter in human risk and safety evaluation for products including chemicals, pesticides, medicines and cosmetics. Historically, this endpoint has been evaluated using the Draize rabbit eye test, an in vivo model that was never formally validated. Due to advances in scientific knowledge, economic and ethical issues, non-animal methods based on mechanisms of toxicity are being developed and validated for increasing the capability of these models to predict eye toxicity. In this study, the Cytometric Bead Array (CBA) and ELISA assays were used to evaluate the inflammatory cytokine profile produced by HaCaT human keratinocytes after exposure to chemicals with different UN GHS eye toxicity classifications, aiming to stablish a correlation between inflammatory endpoints and eye toxicity (damage/irritation) potential...
June 25, 2018: Chemico-biological Interactions
Jorge Willian Franco de Barros, Cibele Dos Santos Borges, Gabriela Missassi, Tainá Louise Pacheco, Wilma De Grava Kempinas
Therapy with betamethasone, a synthetic glucocorticoid, is used in cases of preterm birth risk, in order to promote fetal lung maturation, and decrease neonatal mortality and morbidity. However, late reproductive disorders related to the prenatal exposure to this compound have been reported by our Laboratory, in both male and female rats. Thus, the present study aimed to evaluate the impact of betamethasone on postnatal reproductive development, during pre-puberty, of male offspring exposed in utero to this synthetic glucocorticoid...
June 25, 2018: Chemico-biological Interactions
Elaine Maria de Souza-Fagundes, Johannes Delp, PedroH D M Prazeres, Lucas Bonfim Marques, Arturene Maria Lino Carmo, Pedro Henrique Fazza Stroppa, Nicolas Glanzmann, Jaffar Kisitu, Dàvid Szamosvàri, Thomas Böttcher, Marcel Leist, Adilson David da Silva
Triazoles are interesting templates for novel chemotherapeutic drugs. We synthesized here 17 1,3,4-substituted-1,2,3-triazoles that differed in their 1'-substituent (variable alkyl chain lengths C3-C12), the 3'-substituent (no substituent, -methyl or -propyl) or the salt form obtained. Several of the compounds were cytotoxic (μM range) for tumor cells (HL-60, JURKAT, MCF-7, HCT-116), and when the effect was compared to non-transformed cells (Vero), selectivity ratios of up to 23-fold were obtained. To estimate the liability of these potential drug candidates for triggering neurotoxicity, we used the LUHMES cell-based NeuriTox assay...
June 23, 2018: Chemico-biological Interactions
Shimaa M Elshazly, Dalia M Abd El Motteleb, Islam A A E-H Ibrahim
Stress induced gastric ulcer is a serious health problem in diabetic patients. Some studies reported that hesperidin (HDN), a citrus bioflavonoid, can bind to and stimulate peroxisome proliferator-activator receptor-gamma (PPAR-γ) which may mediate its antidiabetic, anti-inflammatory and anti-oxidant effects. This work aims to study the possible protective effect of HDN against stress induced gastric ulcer in diabetic rats as well as the possible involvement of PPARγ in this effect. Type 2 diabetes was induced using streptozotocin and nicotinamide...
June 23, 2018: Chemico-biological Interactions
Qi Cheng, Yong-Wen Li, Cheng-Fang Yang, Yu-Juan Zhong, He He, Fang-Chan Zhu, Li Li
Methyl ferulic acid (MFA) is a biologically active monomer extracted and purified from the Chinese herbal medicine Securidaca inappendiculata hasskarl. The previously studies showed that MFA improved acute liver injury induced by ethanol. However, the effect of MFA on ethanol-induced hepatic steatosis in alcoholic liver disease (ALD) still remains unclear. The current study was aimed at elucidating the effect of MFA on alcohol-induced hepatic steatosis and the underlying mechanisms. Human hepatocyte L-02 cells exposed to 200 mM ethanol for 24 h to simulate alcoholic steatosis in vitro...
June 22, 2018: Chemico-biological Interactions
Gisele Augusto Rodrigues de Oliveira, Daniela Morais Leme, Joaquín de Lapuente, Lara Barroso Brito, Constança Porredón, Laís de Brito Rodrigues, Natália Brull, Joan Txu Serret, Miquel Borràs, Geonildo Rodrigo Disner, Marta Margarete Cestari, Danielle Palma de Oliveira
The textile dyeing industry is one of the main sectors contributing to environmental pollution, due to the generation of large amounts of wastewater loaded with dyes (ca. 2-50% of the initial amount of dyes used in the dye baths is lost), causing severe impacts on human health and the environment. In this context, an ecotoxicity testing battery was used to assess the acute toxicity and genotoxicity of the textile dyes Direct Black 38 (DB38; azo dye) and Reactive Blue 15 (RB15; copper phthalocyanine dye) on different trophic levels...
June 21, 2018: Chemico-biological Interactions
Xiaoyan Hao, Li Zhang, Xin Zheng, Wansong Zong, Chunguang Liu
More and more composite nano-photocatalysts were developed by doping, modifying and coupling, which expanded its application but resulted in pollution due to the unrecyclability. Composite photocatalyst TiO2 /WO3 /GO, as a model, was evaluated by exploring the molecular mechanism of TiO2 /WO3 /GO-induced activity changes of catalase (CAT) and superoxide dismutase (SOD). Results showed that TiO2 /WO3 /GO could lead to conformational and functional changes of CAT and SOD. The activity of both CAT and SOD increased depending on the exposure dose of TiO2 /WO3 /GO...
June 21, 2018: Chemico-biological Interactions
Umit Yasar
No abstract text is available yet for this article.
June 20, 2018: Chemico-biological Interactions
Lilian Cristina Pereira, Luiz Felipe Cabral Miranda, Mariana Furio Franco-Bernardes, Maria Julia Tasso, Filipe Valente Duarte, Ana Teresa Inácio Varela, Anabela Pinto Rolo, Carlos Manuel Marques Palmeira, Daniel Junqueira Dorta
Brominated flame retardants are used in consumer goods to increase product resistance to fire and/or high temperatures. Polybrominated diphenyl ethers (PBDEs) are the most commonly employed class of brominated flame retardants because they are inexpensive and can effectively prevent flame from spreading. PBDEs are persistent, can bioaccumulate, are transported over long distances, and display toxicity. However, their toxic mechanisms of action have not been well established. Because mitochondria are recognized as the main energy-producing cell organelle and play a vital role in cellular function maintenance, here we apply mitochondria as an experimental model to evaluate the toxic effects of the PBDE congener BDE-153 (Hexa-BDE) at concentrations ranging from 0...
June 20, 2018: Chemico-biological Interactions
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