journal
MENU ▼
Read by QxMD icon Read
search

Chemico-biological Interactions

journal
https://www.readbyqxmd.com/read/27923645/evaluation-of-antioxidant-activity-of-phenolic-fractions-from-the-leaves-and-petals-of-dandelion-in-human-plasma-treated-with-h2o2-and-h2o2-fe
#1
Dariusz Jędrejek, Bogdan Kontek, Bernadetta Lis, Anna Stochmal, Beata Olas
Taraxacum officinale (dandelion) is a widespread perennial of the Asteraceae family. Dandelion is a rich source of different bioactive compounds, including phenolic compounds, terpenes, carbohydrates, proteins, fatty acids, vitamin and minerals. However, the content of phenolics in tested extracts by various authors was not always well described. Dandelion is also a commonly available food with a long history of human use and as such poses little risk of harm. In this study, we focused on four different phenolic fractions from leaves and petals of dandelion, which might be of great interest...
December 3, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27923644/s-and-n-alkylating-agents-diminish-the-fluorescence-of-fluorescent-dye-stained-dna
#2
Robert Giesche, Harald John, Kai Kehe, Annette Schmidt, Tanja Popp, Frank Balzuweit, Horst Thiermann, Thomas Gudermann, Dirk Steinritz
Sulfur mustard (SM), a chemical warfare agent, causes DNA alkylation, which is believed to be the main cause of its toxicity. SM DNA adducts are commonly used to verify exposure to this vesicant. However, the required analytical state-of-the-art mass-spectrometry methods are complex, use delicate instruments, are not mobile, and require laboratory infrastructure that is most likely not available in conflict zones. Attempts have thus been made to develop rapid detection methods that can be used in the field...
December 3, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27923643/anthraquinone-derivative-exerted-hormetic-effect-on-the-apoptosis-in-oxygen-glucose-deprivation-induced-pc12-cells-via-erk-and-akt-activated-nrf2-ho-1-signaling-pathway
#3
Lu Liu, Weiwei Huang, Jianhong Wang, Huiling Song, Juan Cen, Biansheng Ji
There were accumulated evidences that agents may attenuate neurological disorders through a hormetic effect. This study was designed to investigate hormetic effect of BME on the oxygen-glucose deprivation (OGD)-induced mitochondrial apoptosis in NGF-differentiated PC12 cells. The effect of BME on the intracellular reactive oxygen species (iROS) formation and pro-survival signals mediated by ERK and Akt as well as transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) pathways was also determined...
December 3, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27916511/liqustri-lucidi-fructus-inhibits-hepatic-injury-and-functions-as-an-antioxidant-by-activation-of-amp-activated-protein-kinase-in-vivo-and-in-vitro
#4
Hye Lim Seo, Su Youn Baek, Eun Hye Lee, Ju-Hee Lee, Seul-Gi Lee, Kwang-Youn Kim, Mi Hee Jang, Min-Hui Park, Joung-Hee Kim, Keun-Jun Kim, Hyeong Sik Lee, Soon-Cheol Ahn, Jong Rok Lee, Sook Jahr Park, Sang Chan Kim, Young Woo Kim
Medicinal herbs are used to treat or prevent various diseases, and function to regulate protective mechanisms as nutraceuticals. Fructus Ligustri lucidi is the fruit of Ligustrum lucidum and has been used for its tonic effects on the liver. This study was designed to examine the effects of Fructus Ligustri lucidi water extract (FLL) against severe oxidative stress and mitochondrial impairment in vivo and in vitro and to elucidate its cellular mechanisms of action. Treatment of HepG2 cells with arachidonic acid (AA) + iron successfully induced oxidative stress and apoptosis, as indicated by depletion of glutathione, formation of ROS, increases in mitochondrial membrane permeability (MMP), and altered expression of apoptosis-related proteins, such as procaspase-3 and Bcl-xL...
December 1, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27913138/compared-in-vivo-efficiency-of-nanoemulsions-unloaded-and-loaded-with-calixarene-and-soapy-water-in-the-treatment-of-superficial-wounds-contaminated-by-uranium
#5
Sophie Grivès, Guillaume Phan, Céline Bouvier-Capely, David Suhard, François Rebière, Michelle Agarande, Elias Fattal
No emergency decontamination treatment is currently available in the case of radiological skin contamination by uranium compounds. First responders in the workplace or during an industrial nuclear accident must be able to treat internal contamination through skin. For this purpose, a calixarene nanoemulsion was developed for the treatment of intact skin or superficial wounds contaminated by uranium, and the decontamination efficiency of this nanoemulsion was investigated in vitro and ex vivo. The present work addresses the in vivo decontamination efficiency of this nanoemulsion, using a rat model...
November 29, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27908776/3-geranyl-mono-substituted-chalcone-xanthoangelovl-induces-apoptosis-in-human-leukemia-k562%C3%A2-cells-via-activation-of-mitochondrial-pathway
#6
Yuou Teng, Lixin Wang, Huan Liu, Yuan Yuan, Qian Zhang, Meng Wu, Luyao Wang, Haomeng Wang, Zhen Liu, Peng Yu
3'-Geranyl-mono-substituted chalcone Xanthoangelol (1b), a chalcone derivative, was previously reported to show selective cytotoxicity against human chronic myelogenous leukemia K562 cells with a half-maximal inhibitory concentration (IC50) of 3.98 μM. In the present study, we investigated the molecular mechanism underlying the cytotoxicity of 1b in K562 cells. Treatment with compound 1b caused K562 cells to adopt a typical apoptotic morphology. Flow cytometric analysis also confirmed the presence of an apoptotic cell population following treatment of Annexin-V-FITC and propidium iodide (PI) double-labeled K562 cells with 1b...
November 29, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27908777/mdr-alcohol-dehydrogenases
#7
Hans Jörnvall
Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding structural, functional and evolutionary properties. They can be traced backwards in at least six stages of development, to essentially the origin of cellular life, and have been monitored in a long series of biannual meetings on "Carbonyl Metabolism". In between each of these meetings, a roughly three-fold increase in known totals of MDR databank entries has been apparent, bringing the total now of known MDR-ADH entries to approaching half a million forms...
November 28, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27899290/didymin-induces-apoptosis-through-mitochondrial-dysfunction-and-up-regulation-of-rkip-in-human-hepatoma-cells
#8
Jinbin Wei, Quanfang Huang, Facheng Bai, Jun Lin, Jinlan Nie, Shengjuan Lu, Chunyuang Lu, Renbin Huang, Zhongpeng Lu, Xing Lin
In the present study, a flavonoid was isolated from Origanum vulgare and identified as didymin. The effect and mechanism of O. vulgare didymin (OVD) on human HepG2 liver carcinoma cell was then assessed. Our results showed that OVD strongly inhibited the viability, clonogenicity and migration of HepG2 cells. OVD significantly induced apoptosis and induced cell cycle arrest at G2/M phase by regulating cyclin B1, cyclin D1 and CDK4. The anti-proliferative and pro-apoptotic effects were associated with changes in the Bcl-2/Bax ratio and induction of caspase-mediated apoptosis...
November 27, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27899289/protective-propensity-of-bacoside-a-and-bromelain-on-renal-cholinesterases-%C3%AE-aminobutyric-acid-and-serotonin-level-of-mus-musculus-intoxicated-with-dichlorvos
#9
Sonam Agarwal, Bharti Chaudhary, Renu Bist
Current study established a protective action of bacoside A and bromelain against the toxic effects of dichlorvos in kidneys of mice. Experimental design included five groups. The first group was control. Mice of groups II, III and IV were administered doses of dichlorvos, bromelain and bacoside A respectively. In group V, mice were treated with both the antioxidants (bacoside A and bromelain) and dichlorvos. After 21 days of exposure of different doses, levels of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), γ-aminobutyric acid (GABA) and serotonin were measured in renal tissues...
November 27, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27894855/galloylquinic-acid-derivatives-from-copaifera-langsdorffii-leaves-display-gastroprotective-activity
#10
Erick V S Motta, Marivane Lemos, Juliana C Costa, Vilmar C Banderó-Filho, Astrid Sasse, Helen Sheridan, Jairo K Bastos
Nine new methylated galloylquinic acids were isolated from an aqueous fraction of Copaifera langsdorffii (Fabaceae-Caesalpinioideae) leaf hydroalcoholic extract (3-8, 11, 12, and 14), along with three known methylated galloylquinic acids (1, 2, and 15) and four galloylquinic acids (9, 10, 13, and 16). These compounds were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. They were further tested in a gastroprotection assay (Ethanol-HCl induced ulcer model in mice), in which all of them significantly reduced the total lesion area, and increased the cure ratio in comparison with pantoprazole...
November 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27889497/in%C3%A2-vivo-effect-of-borneol-on-rat-hepatic-cyp2b-expression-and-activity
#11
Jing-Ya Chen, Xiang-Tao Huang, Jun-Jun Wang, Yong Chen
CYP2B subfamily accounts for 2-10% of total hepatic CYP450 enzymes and participate in the metabolism of around 8% of clinical drugs. Borneol has been widely used in traditional Chinese medicine for thousands of years. There are many studies about borneol-induced promoting penetration role for a number of drugs through various physiologic barriers, whereas there is no report involved the effect of borneol on hepatic CYP2B. The present work studied the in vivo effect of borneol on the expression and activity of rat hepatic CYP2B...
November 23, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27887929/anti-vascular-inflammatory-effects-of-pentacyclic-triterpenoids-from-astilbe-rivularis-in%C3%A2-vitro-and-in%C3%A2-vivo
#12
Hyejin Kang, Sae-Kwang Ku, Jongdoo Kim, Jiwoo Chung, Sang Chan Kim, Wei Zhou, MinKyun Na, Jong-Sup Bae
Sepsis is a systemic inflammatory condition resulting from bacterial infections. It is associated with high mortality rates, and its therapeutic options are limited. Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix protein that functions as a mediator of experimental sepsis. C-27-carboxylated pentacyclic triterpenoids are specifically found in species of the genus Astilbe, and show several biological effects. Given the anti-inflammatory effects of pentacyclic triterpenoids, we investigated the effects of 3β-trans-p-coumaroyloxy-olean-12-en-27-oic acid (1) and 6β-hydroxy-3-oxoolean-12-en-27-oic acid (2) on TGFBIp-mediated vascular inflammatory responses...
November 22, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27887928/degradation-of-paraoxon-vx-chemical-agent-simulant-and-bacteria-by-magnesium-oxide-depends-on-the-crystalline-structure-of-magnesium-oxide
#13
A Sellik, T Pollet, L Ouvry, S Briançon, H Fessi, D J Hartmann, F N R Renaud
In this work, our goal was to study the capability of a single metallic oxide to neutralize a chemical agent and to exhibit an antibacterial effect. We tested two types of magnesium oxides, MgO. The first MgO sample tested, which commercial data size characteristic was -325 mesh (MgO-1) destroyed in 3 h, 89.7% of paraoxon and 93.2% of 4-nitrophenol, the first degradation product. The second MgO sample, which commercial data size was <50 nm (MgO-2) neutralized in the same time, 19.5% of paraoxon and 10...
November 22, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27876602/genistein-attenuates-d-galn-induced-liver-fibrosis-chronic-liver-damage-in-rats-by-blocking-the-tgf-%C3%AE-smad-signaling-pathways
#14
Ajaz Ahmad Ganai, Mohammad Husain
BACKGROUND AND AIM: Genistein is a major isoflavonoid abundantly found in soy. Earlier genistein has been reported to possess protective effect against a multitude of disorders including cancer. Previously we demonstrated the protective effects of Genistein in d-Galactosamine (D-GalN) induced fulminant hepatic failure (FHF) in rats. In present study, we evaluated the hepatoprotective activity of Genistein in rat model of chronic liver damage and liver fibrosis. METHODS: Liver fibrosis was induced by intraperitoneal injection of D-GalN (250 mg/kg BW) twice a week for 12 weeks...
November 19, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27876601/bioapplications-of-graphene-constructed-functional-nanomaterials
#15
REVIEW
Arif Gulzar, Piaoping Yang, Fei He, Jiating Xu, Dan Yang, Liangge Xu, Mohammad Omar Jan
Graphene has distinctive mechanical, electronic, and optical properties, which researchers have applied to develop innovative electronic materials including transparent conductors and ultrafast transistors. Lately, the understanding of various chemical properties of graphene has expedited its application in high-performance devices that generate and store energy. Graphene is now increasing its terrain outside electronic and chemical applications toward biomedical areas such as precise bio sensing through graphene-quenched fluorescence, graphene-enhanced cell differentiation and growth, and graphene-assisted laser desorption/ionization for mass spectrometry...
November 19, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27871899/balkan-endemic-nephropathy-still-continuing-enigma-risk-assessment-and-underestimated-hazard-of-joint-mycotoxin-exposure-of-animals-or-humans
#16
REVIEW
Stoycho D Stoev
The spreading of mycotoxic nephropathy in animals/humans was studied. The possible etiological causes provoking this nephropathy were carefully reviewed and analyzed. The natural content of the most frequent nephrotoxic mycotoxins in target feedstuffs/foods were investigated, in addition to their significance for development of renal damages in endemic areas. An estimation of the level of exposure of humans to the nephrotoxic mycotoxin, ochratoxin A (OTA), is made. The possible synergism or additive effects between some target mycotoxins in the development of nephropathy is also covered...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27871898/the-cannabinoid-beta-caryophyllene-bcp-induces-neuritogenesis-in-pc12-cells-by-a-cannabinoid-receptor-independent-mechanism
#17
Neife Aparecida Guinaim Santos, Nádia Maria Martins, Flávia Malvestio Sisti, Laís Silva Fernandes, Rafaela Scalco Ferreira, Osvaldo de Freitas, Antônio Cardozo Santos
Beta-caryophyllene (BCP) is a phytocannabinoid whose neuroprotective activity has been mainly associated with selective activation of cannabinoid-type-2 (CB2) receptors, inhibition of microglial activation and decrease of inflammation. Here, we addressed the potential of BCP to induce neuritogenesis in PC12 cells, a model system for primary neuronal cells that express trkA receptors, respond to NGF and do not express CB2 receptors. We demonstrated that BCP increases the survival and activates the NGF-specific receptor trkA in NGF-deprived PC12 cells, without increasing the expression of NGF itself...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27871897/sauchinone-exerts-anticancer-effects-by-targeting-ampk-signaling-in-hepatocellular-carcinoma-cells
#18
Young Woo Kim, Eun Jeong Jang, Chang-Hyun Kim, Ju-Hee Lee
Sauchinone is a pharmacologically active compound isolated from Saururus chinensis, which has been used as a traditional Oriental medicine to treat fever, jaundice, and various inflammatory diseases. In this study, we investigated the effect of sauchinone against hepatocellular carcinoma (HCC) and sought to elucidate the mechanism involved. Cell viability was measured by an MTT assay. Cell cycle distributions and the mitochondrial membrane potential were analyzed using flow cytometry. Cell death was analyzed by annexin V assay, 4',6-diamidino-2-phenylindole staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27871896/gastroprotective-and-ulcer-healing-effects-of-hydroethanolic-extract-of-leaves-of-caryocar-coriaceum-mechanisms-involved-in-the-gastroprotective-activity
#19
Luis Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Valterlucio Santos Sales, Severino Denicio Gonçalves de Souza, Antonia Thassya Lucas Dos Santos, Larissa Rolim de Oliveira, Marta Regina Kerntopf, Thais Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans-Júnior, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes
This work aimed to determine the chemical fingerprint of hydroethanolic extract of leaves of Caryocar coriaceum (HELCC) and the gastroprotective activity. The chemical fingerprint of HELCC was analyzed by HPLC-DAD, to quantify total phenols and flavonoids were carried out by Folin-Ciocalteu reagent and aluminum chloride assay, while in vitro antioxidant activity was evaluated by the DPPH method. The methods used to determine pharmacological activity were: gastroprotective screening test in classical models of induced acute and chronic gastric lesions and physical barrier test...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27871895/protective-effect-of-lycopene-on-fluoride-induced-ameloblasts-apoptosis-and-dental-fluorosis-through-oxidative-stress-mediated-caspase-pathways
#20
Weishan Li, Binghua Jiang, Xianglin Cao, Yongjiang Xie, Ting Huang
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by orally administration for 5 weeks; ameloblasts were treated with NaF (5 mM) and/or LYC (2 μM) for 6 h. We found that the concentrations of fluoride, malondialdehyde (MDA) and reactive oxygen species (ROS), gene expressions and activities of Caspase-9 and Caspase-3, and the gene expressions of Bax were significantly decreased, while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated rats group; concentrations of MDA and ROS, gene expressions and activities of Caspase-9 and Caspase-3, and the gene expression of Bax, and ameloblasts apoptosis rate were significantly decreased, while the activities of SOD and GPX, the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated ameloblasts group...
November 18, 2016: Chemico-biological Interactions
journal
journal
22326
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"