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Chemico-biological Interactions

Mehdi Nematbakhsh
No abstract text is available yet for this article.
September 14, 2018: Chemico-biological Interactions
Dongdong Sun, Feng Zhang, Jie Qian, Weixing Shen, Huisen Fan, Jiani Tan, Liu Li, Changliang Xu, Ye Yang, Haibo Cheng
Angiogenesis is fundamental for solid tumor growth and metastasis, and anti-angiogenic therapy has been an important therapeutic option for cancer treatment. Colorectal cancer (CRC) represents the fourth leading cause of cancer-related death worldwide. The current studies were aimed at investigating the anti-angiogenic effects of the natural compound 4'-hydroxywogonin (4'-HW) on CRC-related angiogenesis. Human CRC cell line SW620 cells and normal human intestinal epithelial HIEC cells were cultured and treated with interleukin-6 to mimic the tumor inflammatory microenvironment...
September 12, 2018: Chemico-biological Interactions
Kwang Sik Suh, Suk Chon, Woon-Won Jung, Eun Mi Choi
Methylglyoxal (MG) is a reactive dicarbonyl compound produced by glycolytic processing, which has been identified as a precursor of advanced glycation end products. Elevated MG levels in patients with diabetes are believed to contribute to diabetic complications, including bone defects. The objective of this study was to evaluate the effect of MG on RANKL-induced osteoclast differentiation in RAW264.7 cells, a murine macrophage cell line. RAW264.7 cells were cultured in medium containing 50 ng/mL RANKL and different concentrations of MG...
September 12, 2018: Chemico-biological Interactions
Marloes Ja Joosen, Steven D Klaassen, Elwin Verheij, Tomas van Groningen, Alex S Cornelissen, Mario H Skiadopoulos, Laura Cochrane, Jeff D Shearer
The efficacy and pharmacokinetics of the aqueous co-formulation contents of the TROBIGARD™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated in guinea pigs instrumented with brain and heart electrodes for electroencephalogram (EEG) and electrocardiogram (ECG). Sarin challenge doses were chosen to reflect exposure subclasses with sublethal (moderate to severe clinical signs) and lethal consequences...
September 11, 2018: Chemico-biological Interactions
Sakine Shirvalilou, Samideh Khoei, Sepideh Khoee, Nida Jamali Raoufi, Mohammad Reza Karimi, Ali Shakeri-Zadeh
To overcome the obstacles inflicted by the BBB in Glioblastoma multiforme (GBM) we investigated the use of Multifunctional nanoparticles that designed with a Nano-graphene oxide (NGO) sheet functionalized with magnetic poly (lactic-co-glycolic acid) (PLGA) and was used for glioma targeting delivery of radiosensitizing 5-iodo-2-deoxyuridine (IUdR). In vitro biocompatibility of nanocomposite has been studied by the MTT assay. In vivo efficacy of magnetic targeting on the amount and selectivity of magnetic nanoparticles accumulation in glioma-bearing rats under an external magnetic field (EMF) density of 0...
August 28, 2018: Chemico-biological Interactions
Wei Sheng, Zhi-Cai Zhang, De-Yao Shi, Bai-Chuan Wang, Qiang Wu, Zeng-Wu Shao, Shu-Hua Yang, Tong-Chuan He, Jian-Xiang Liu
BACKGROUD/AIMS: Abnormal activation of the Wnt/β-catenin signaling, which may be antagonized by the members of secreted frizzled-related proteins family (SFRPs), is implicated in tumor occurrence and development. However, the function of SFRP5 relating to Wnt/β-catenin pathway in chondrosarcoma is not clear yet. This study was undertaken to investigate the potential role of SFRP5 promoter methylation in chondrosarcoma metastasis and invasion through activating canonical Wnt signaling pathway...
August 18, 2018: Chemico-biological Interactions
Yujie Zhong, Chengni Jin, Xiaorui Wang, Xuan Li, Jiahui Han, Wei Xue, Peng Wu, Xiaoli Peng, Xiaodong Xia
Apigenin (API) is a kind of important flavonoid present in temperate and tropical fruit and vegetables, especially the celery. It exerts anticancer, anti-bacterial, anti-viral, anti-inflammatory, anti-oxidation properties. In the present study, the mechanism of protective action of apigenin on 3-chloro-1, 2-propanediol (3-MCPD)-induced renal injury was investigated in rat. Sprague-Dawley (SD) rats were divided into five groups: control group (ultrapure water treated), CMC group (sodium carboxymethylcellulose treated), 3-MCPD treatment group (30 mg/kg body weight/day), 3-MCPD plus API co-treatment group (20, 40 mg/kg body weight/day)...
August 11, 2018: Chemico-biological Interactions
Nandita Dasgupta, Shivendu Ranjan, Debasish Mishra, Chidambaram Ramalingam
Silver nanoparticles (AgNPs) are being commercialized in a number of consumer products including food and cosmetics where there is a direct exposure of AgNPs to human body. An extensive toxicological evaluation is necessary to understand the mechanism for its safe use, since the toxicity effect varies greatly with the synthesis protocol followed. In this study, we report the detailed toxicological analysis of AgNPs fabricated by thermal co-reduction approach. Our study was analysed in human colon cancer cell line (HCT 116) and the IC50 was calculated as 28...
July 27, 2018: Chemico-biological Interactions
Wided N Missaoui, Robert D Arnold, Brian S Cummings
The field of nanotechnology has grown exponentially during the last few decades, due in part to the use of nanoparticles in many manufacturing processes, as well as their potential as clinical agents for treatment of diseases and for drug delivery. This has created several new avenues by which humans can be exposed to nanoparticles. Unfortunately, investigations assessing the toxicological impacts of nanoparticles (i.e. nanotoxicity), as well as their possible risks to human health and the environment, have not kept pace with the rapid rise in their use...
July 23, 2018: Chemico-biological Interactions
Rahul S Kalhapure, Jwala Renukuntla
A new generation of the more effective polymeric micelle and nanoparticle drug delivery systems evolved due to the emergence of stimuli-responsive polymers. Among various stimuli, pH and temperature are most widely studied for enhanced drug release at the site of action. Researchers are focusing on dual (pH and temperature) responsive polymeric micelles and nanoparticles for controlled and enhanced drug release at the site of action. These dual responsive systems are mainly evaluated for cancer therapy as certain malignancies can cause a slight increase in temperature and decrease in extracellular pH around the tumor site...
July 20, 2018: Chemico-biological Interactions
Shibing Su, Anbu Karani Adikesavan, Anil K Jaiswal
This article has been retracted: please see Elsevier Policy on Article Withdrawal ( This article has been retracted at the request of the Office of Integrity of the University of Maryland due to data entered in Fig 3 of the publication that were not supported by raw data, in addition to the fact that the statistical evaluations were adultered.
October 1, 2018: Chemico-biological Interactions
Virginia Rubio, Ana I García-Pérez, Angel Herráez, José C Diez
Esculetin (6,7-dihydrocoumarin) and the flavonoid quercetin (3,5,7,3',4' pentahydroxyflavone) are compounds that could change the balance of redox homeostasis. NB4 leukemia cells were treated with 25 μM quercetin for 24 h and with esculetin at either 100 or 500 μM for different times. Quercetin increased the levels of pro-inflammatory NFkB p65 in the nucleus correspondingly reducing them in the cytosol. The levels of NFkB p65 decreased in the nucleus at high esculetin concentration treatments for long times (19 h), concomitantly increasing the levels of anti-inflammatory NFkB p50 in the nucleus...
October 1, 2018: Chemico-biological Interactions
Shawgi Hago Almugadam, Alessandro Trentini, Martina Maritati, Carlo Contini, Gianluca Rugna, Tiziana Bellini, Maria Cristina Manfrinato, Franco Dallocchio, Stefania Hanau
6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. It is converted by a NAD(P)+ glycohydrolase to 6-aminoNAD and 6-aminoNADP, causing the accumulation of PPP intermediates, due to their inability to participate in redox reactions. Some parasites like Plasmodium falciparum and Coccidia are highly sensitive but not all cell types showed a strong responsiveness to 6AN, probably due to the different targeted pathway...
October 1, 2018: Chemico-biological Interactions
Kwang-Youn Kim, Kwang-Il Park, Seul Gi Lee, Su Youn Baek, Eun Hye Lee, Sang Chan Kim, Sang-Hun Kim, Sul-Gi Park, Sun-Nyoung Yu, Tae Woo Oh, Joung-Hee Kim, Keuk-Jun Kim, Soon-Cheol Ahn, Young Woo Kim
Deoxypodophyllotoxin (DPT) is a naturally occurring flavolignan in Anthriscus sylvestris known as cow parsley or wild chervil, and has been reported to have inhibitory effects against several pathological processes including cancer, inflammation and infection. Here, we report the effects of DPT in the fatty liver induced by high fat diet in vivo as well as its regulatory mechanism related with the transcription factor for lipogenic genes such as sterol regulatory element binding protein-1c (SREBP-1c) in vitro...
October 1, 2018: Chemico-biological Interactions
Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Hee-Yun Kim, Sungwei Hong, Hyeong-Jin Kim, Min-Sun Yoo, Hyung-Min Kim, Hyun-Ja Jeong
Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently affects about 30% of people worldwide. β-eudesmol has various beneficial effects, including anti-cancer and anti-allergic activities. However, the effects of β-eudesmol on AR have not yet been clarified; thus, we investigated the effects of β-eudesmol in an ovalbumin-induced AR animal model using enzyme-linked immunosorbent assay, histamine assay, Western blotting, and hematoxylin and eosin staining methods...
October 1, 2018: Chemico-biological Interactions
Sreenivasulu Dasari, Muni Swamy Ganjayi, Prabhakar Yellanurkonda, Sreenivasulu Basha, Balaji Meriga
Glutathione S-transferases (GSTs), the versatile phase II biotransformation enzymes, metabolize and detoxify a wide variety of toxic chemical compounds like carcinogens, chemotherapeutic drugs, environmental pollutants and oxidative stress products. GSTs are currently of great interest in drug discovery, nanotechnology and biotechnology because of their involvement in many major cellular processes. GSTs, which are either homo or hetero dimeric proteins mediate catalytic binding between glutathione (GSH) and an array of either endogenous or exogenous toxic compounds to form a highly soluble detoxified complex which is then eliminated...
October 1, 2018: Chemico-biological Interactions
Meric A Altinoz, Ayhan Bilir, İlhan Elmaci
BACKGROUND: PPAR-δ is a transcription factor which has crucial roles in stimulating oligodendroglial differentiation and myelination and its activation was also shown to differentiate malignant C6 glioma cells into oligodendrocytes. OBJECTIVE: One of the ligands of PPAR-δ is erucic acid (EA), an edible omega-9 fatty acid consumed more by Asian populations and exists highly in Chinese womens milk. There exist epidemiological evidence that pediatric brain tumor incidence is among the lowest in the Chinese population...
October 1, 2018: Chemico-biological Interactions
Hye Jin Cheon, Sang-Hyeon Nam, Jin-Kyung Kim
Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments are associated with poor tolerability and insufficient therapeutic efficacy, prompting the need for alternative therapeutic approaches. Recent advances suggest promising interventions based on a number of phytochemicals. Herein, we explored the beneficial effects of tussilagone, a major component of Tussilago farfara, in mice subjected to acute colitis induced by dextran sulfate sodium (DSS)...
October 1, 2018: Chemico-biological Interactions
Laila Ahmed Eissa, Hany Ibrahim Kenawy, Amro El-Karef, Nehal Mohsen Elsherbiny, Kholoud Alaa El-Mihi
Berberine (BBR) is an isoquinoline alkaloid extracted from the roots, rhizomes and stems of coptis. Liver fibrosis is a worldwide health problem with no established therapy until now. The aim of our study is to investigate the efficacy of BBR on hepatic fibrosis induced in rats and to uncover other mechanisms. Rats were injected with thioacetamide (TAA) (200 mg/kg, i.p) twice per week for 6 weeks to induce fibrosis. Treated groups were gavaged with BBR (50 mg/kg/day, p.o) simultaneously with TAA injection...
October 1, 2018: Chemico-biological Interactions
Nagah E Edrees, Azza A A Galal, Aliaa R Abdel Monaem, Rasha R Beheiry, Mohamed M M Metwally
Colistin is an effective antibiotic against multidrug-resistant (MDR) gram-negative bacterial infections; however, nephrotoxic and neurotoxic effects are fundamental dose-limiting factors for this treatment. This study was conducted to assess the potential protective effects of curcumin, a phenolic constituent of turmeric, against colistin-induced nephrotoxicity and neurotoxicity, and the possible mechanisms underlying any effect. Twenty-four adult male albino rats were randomly classified into 4 equal groups; the control group (orally received saline solution), the curcumin-treated group (orally administered 200 mg curcumin/kg/day), the colistin-treated group (IP administered 300,000 IU colistin/kg/day) and the concurrent group (orally received 200 mg curcumin/kg/day concurrently with colistin injection); all rats were treated for 6 successive days...
October 1, 2018: Chemico-biological Interactions
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