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Chemico-biological Interactions

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https://www.readbyqxmd.com/read/28526264/celecoxib-aggravates-cardiac-apoptosis-in-l-name-induced-pressure-overload-model-in-rats-immunohistochemical-determination-of-cardiac-caspase-3-mcl-1-bax-and-bcl-2
#1
Sarah M Mosaad, Sawsan A Zaitone, Abdelazim Ibrahim, Amani A El-Baz, Dina M Abo-Elmatty, Yasser M Moustafa
The mechanism of celecoxib cardiovascular adverse events was earlier investigated; yet in-depth investigations are needed to assess the involvement of its pro-apoptotic effect throughout this process. An in-vivo chronic rat model of pressure overload employing Nʷ-nitro-l-arginine methyl ester (L-NAME) was tested at different time intervals to ensure the occurrence of persistent myocardial apoptosis along with pressure overload. Seven groups of male Wistar rats were assigned as (i) distilled water; (ii-iv) L-NAME (60 mg/kg) for 6, 12 or 16 weeks; (v-vii) L-NAME [16 weeks] + celecoxib (25, 50 or 100 mg/kg), from week 13 to week 16...
May 16, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28526263/n-stearoyl-l-tyrosine-inhibits-the-cell-senescence-and-apoptosis-induced-by-h2o2-in-hek293-tau-cells-via-the-cb2-receptor
#2
Yue Hu, Kai-Yi Zhou, Ze-Jian Wang, Yang Lu, Ming Yin
Although considerable energy and money have been spent trying to inhibit Aβ production and its related metabolic enzyme activities, there are still no drug treatments available to cure even slow for Alzheimer's disease. Therefore, tau protein has been focused recently as the new target for the treatment of Alzheimer's disease. The transfected human embryonic kidney 293 (HEK 293) cells with or without Tau 411 plasmid were used to evaluate the effect of tau protein on cell viability. H2O2 was added to simulate microenvironment of oxidative stress (OS) during aging...
May 16, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28512001/low-dose-inflammatory-potential-of-silica-particles-in-human-derived-thp-1-macrophage-cell-culture-studies-mechanism-and-effects-of-particle-size-and-iron
#3
Premshekharan Gayatri, Hongqiao Zhang, Kennedy Nguyen, Henry Jay Forman, Valerie Jean Leppert
Silica and iron are major constituents in ambient particulate matter, and iron is a common impurity in many engineered nanomaterials. The purpose of this work was to determine the pro-inflammatory and other biological effects and mechanism of particle size and iron presence under low dose, non-cytotoxic conditions that are likely to approximate actual exposure levels, in contrast with higher dose studies in which cytotoxicity occurs. Specifically, human-derived THP-1 macrophages were exposed to 1 μg/ml of pristine and iron-coated 50 nm and 2 μm engineered silica nanoparticles...
May 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28506553/inhibition-of-12-15-lo-ameliorates-cvb3-induced-myocarditis-by-activating-nrf2
#4
Feng Ai, Jiayong Zheng, Yanwei Zhang, Taibing Fan
Cardiac 12/15-lipoxygenase (12/15-LO) was reported to be markedly up-regulated and involved in the development of heart failure. Nuclear factor E2-related factor 2 (Nrf2) plays anti-inflammatory and anti-oxidation roles in response to oxidative stress. However, the role of 12/15-LO in viral myocarditis (VMC) and its underlying molecular mechanism have not yet been elucidated. Here, we demonstrated that 12/15-LO was up-regulated and Nrf2 was down-regulated in coxsackievirus B3 (CVB3)-infected mice and cardiac myocytes...
May 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28506552/the-natural-terthiophene-%C3%AE-terthienylmethanol-induces-s-phase-cell-cycle-arrest-of-human-ovarian-cancer-cells-via-the-generation-of-ros-stress
#5
Umma Hafsa Preya, Kyung-Tae Lee, Nam-Jung Kim, Jung-Yun Lee, Dae Sik Jang, Jung-Hye Choi
Ovarian cancer is the most lethal gynecological malignancy worldwide. Thiophenes such as terthiophene have been shown to have anti-tumor effects on several cancer cell lines, including ovarian cancer cells. However, the underlying mechanisms behind the anti-proliferative effect of thiophenes are poorly understood. In this study, we investigated the molecular mechanisms underlying the anti-proliferative effect of α-terthienylmethanol, a terthiophene isolated from Eclipta prostrata (False Daisy), on human ovarian cancer cells...
May 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28499986/n-acetylcysteine-treatment-attenuates-the-cognitive-impairment-and-synaptic-plasticity-loss-induced-by-streptozotocin
#6
Michael da Costa, Jamile Bernardi, Lidiane Costa, Tiago Fiuza, Ricardo Brandão, Maria F Ribeiro, Joana D Amaral, Cecília M P Rodrigues, Maria E Pereira
Alzheimer's disease (AD) is a neurodegenerative disorder pathologically characterized by severe neuronal and glial structural changes and progressive cognitive decline. N-acetylcysteine (NAC) is a well-known pharmacological agent with pro-neurogenic properties and neuroprotective effects. In this study, we evaluated NAC protective effects on cognitive impairment and associated pathological markers in a streptozotocin (STZ)-induced sporadic dementia of AD type mice model. Animals were divided into six groups: I) Sham, II) NAC, III) physostigmine (PHY), IV) STZ, V) NAC + STZ and VI) PHY + NAC...
May 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28495429/superoxide-hydrogen-peroxide-genetic-imbalance-modulates-differentially-the-oxidative-metabolism-on-human-peripheral-blood-mononuclear-cells-exposed-to-seleno-l-methionine
#7
Karen Lilian Schott, Charles Elias Assmann, Fernanda Barbisan, Verônica Farina Azzolin, Beatriz Bonadiman, Marta Maria Medeiros Frescura Duarte, Alencar Kolinski Machado, Ivana Beatrice Mânica da Cruz
Superoxide-hydrogen peroxide (S-HP) imbalance genetically caused by a gene polymorphism in the human manganese superoxide dismutase enzyme (Val16Ala-MnSOD) is associated with several dysfunctions and diseases. Into mitochondria, MnSOD catalyses superoxide radical producing hydrogen peroxide and oxygen. Ala-MnSOD genotype presents a high MnSOD efficiency and generates the highest H2O2 concentrations that has been associated with the risk of several cancer types. Cellular selenoenzymes glutathione peroxidase and thioredoxin reductase (TrxR) as well as catalase (CAT) are essential to H2O2 removal produced in excess in cells...
May 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28483572/early-energy-metabolism-related-molecular-events-in-skeletal-muscle-of-diabetic-rats-the-effects-of-l-arginine-and-sod-mimic
#8
Ana Stancic, Milos Filipovic, Ivana Ivanovic-Burmazovic, Sava Masovic, Aleksandra Jankovic, Vesna Otasevic, Aleksandra Korac, Biljana Buzadzic, Bato Korac
Considering the vital role of skeletal muscle in control of whole-body metabolism and the severity of long-term diabetic complications, we aimed to reveal the molecular pattern of early diabetes-related skeletal muscle phenotype in terms of energy metabolism, focusing on regulatory mechanisms, and the possibility to improve it using two redox modulators, l-arginine and superoxide dismutase (SOD) mimic. Alloxan-induced diabetic rats (120 mg/kg) were treated with l-arginine or the highly specific SOD mimic, M40403, for 7 days...
May 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28483571/sinigrin-attenuates-the-progression-of-atherosclerosis-in-apoe-mice-fed-a-high-cholesterol-diet-potentially-by-inhibiting-vcam-1-expression
#9
Yeon Jeong Jang, Bongkyun Park, Hee-Weon Lee, Hye Jin Park, Hyun Jung Koo, Byung Oh Kim, Eun-Hwa Sohn, Sung Hee Um, Suhkneung Pyo
Atherosclerosis is a complex inflammatory disease associated with elevated levels of atherogenic molecules for leukocyte recruitment. Sinigrin (2-propenylglucosinolate) is found mainly in broccoli, brussels sprouts, and black mustard seeds. Recently, sinigrin has received attention for its role in disease prevention and health promotion. In this study, we examined the effect of sinigrin on development of atherosclerosis in ApoE(-/-) mice and the expression of adhesion molecules in vascular smooth muscle cells (VSMCs)...
May 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28479099/protective-effect-of-chlorogenic-acid-against-methotrexate-induced-oxidative-stress-inflammation-and-apoptosis-in-rat-liver-an-experimental-approach
#10
Nemat Ali, Summya Rashid, Sana Nafees, Syed Kazim Hasan, Ayaz Shahid, Ferial Majed, Sarwat Sultana
Methotrexate (MTX) is a drug which is used to treat different types of cancers but hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant naturally occurring polyphenols in the human diet. Here, we assessed the effect of CGA against MTX-induced hepatotoxicity and investigated the underlying possible mechanisms in Wistar Rats. Rats were pre-treated with CGA (50 or 100 mg kg/b.w) and administered a single dose of MTX (20 mg/kg, b.w.). MTX caused hepatotoxicity as evidenced by significant increase in serum toxicity markers, histopathological changes...
May 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28479098/synthesis-cytotoxicity-and-antifungal-activity-of-5-nitro-thiophene-thiosemicarbazones-derivatives
#11
Luiz Nascimento de Araújo Neto, Maria do Carmo Alves de Lima, Jamerson Ferreira de Oliveira, Edson Rubhens de Souza, Maria Daniela Silva Buonafina, Mayara Nunes Vitor Anjos, Fábio André Brayner, Luiz Carlos Alves, Rejane Pereira Neves, Francisco Jaime Bezerra Mendonça-Junior
In the present work, twelve N-substituted 2-(5-nitro-thiophene)-thiosemicarbazones derivatives (L1-12) were synthesized, characterized and their cytotoxic and antifungal activity in vitro were evaluated against Candida sp., and Cryptococcus neoformans. The probable mechanisms of action have been investigated in cell walls (Sorbitol 0.8 M) and in the binding to ergosterol in the fungal membrane. Additionally, ultrastructural study by Scanning Electron Microscopy was performed. All compounds were obtained in good yield and their chemical structures were characterized on basis of their physico-chemical and Nuclear Magnetic Resonance - NMR, Spectrophotometric Absorption in the Infrared - IR and High-resolution Mass Spectrometry - HRMS data...
May 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28477960/in%C3%A2-vitro-and-in%C3%A2-vivo-anticancer-activity-of-posterior-salivary-gland-toxin-from-the-cuttlefish-sepia-pharaonis-ehrenberg-1831
#12
Ramachandran Karthik, Venkatesan Manigandan, Kesavarao Kumar Ebenezar, R Vijayashree, Ramachandran Saravanan
Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. The cytostatic potentials of the PSG toxin was determined by the lymphocyte migration inhibition assay. The PSG toxin (50 μg/ml) effectively inhibited the migration of lymphocytes across the agarose gel matrix under the presence of lipopolysaccharide mitogen...
May 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28476604/oak-kombucha-protects-against-oxidative-stress-and-inflammatory-processes
#13
B D Vázquez-Cabral, M Larrosa-Pérez, J A Gallegos-Infante, M R Moreno-Jiménez, R F González-Laredo, J G Rutiaga-Quiñones, C I Gamboa-Gómez, N E Rocha-Guzmán
Black tea infusion is the common substrate for preparing kombucha; however other sources such as oak leaves infusions can be used for the same purpose. Almost any white oak species have been used for medicinal applications by some ethnic groups in Mexico and could be also suitable for preparing kombucha analogues from oak (KAO). The objective of this research was to investigate the antioxidant activity and anti-inflammatory effects of KAO by examining its modulation ability on macrophage-derived TNF-alpha and IL-6...
May 3, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28465020/salidroside-attenuates-colistin-induced-neurotoxicity-in-rsc96-schwann-cells-through-pi3k-akt-pathway
#14
Ziyin Lu, Guozheng Jiang, Ying Chen, Jian Wang, Ishfaq Muhammad, Ling Zhang, Rui Wang, Fangping Liu, Rui Li, Feng Qian, Jichang Li
Neurotoxicity is a key dose-limiting factor for colistin therapy. This study aimed to investigate the protective effect of Salidroside on colistin-induced neurotoxicity in RSC96 Schwann cells and the underlying mechanisms. After Salidroside (12.5, 25, 50 μg/mL) treatment for 2 h, the cells were cultured with 250 μg/mL colistin for 24 h. In order to investigate the role of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, the cells were pre-treated with LY294002 (12.5 μmol/L, a specific inhibitor of PI3K phosphorylation) for 1 h before Salidroside (50 μg/mL) treatment, then were co-cultured with colistin (250 μg/mL) for 24 h...
April 29, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28460884/enhanced-therapeutic-benefit-of-quercetin-loaded-phytosome-nanoparticles-in-ovariectomized-rats
#15
Abeer I Abd El-Fattah, Mohamed M Fathy, Zeinab Y Ali, Abd El-Rahman A El-Garawany, Ehsan K Mohamed
Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally. To improve its bioavailability, we prepared quercetin-loaded phytosome nanoparticles (QP) using the thin film hydration method. The prepared nano-formulations were characterized using different techniques. Transmission electron microscopy revealed the homogeneously spherical, well and uniformly dispersed, nano-sized nature of QP. Dynamic light scattering measurements of QP (70 ± 7.44 nm) also confirmed this...
April 29, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28457857/bone-marrow-mesenchymal-stem-cells-repair-cadmium-induced-rat-testis-injury-by-inhibiting-mitochondrial-apoptosis
#16
Yong-Jie Wang, Jun Yan, Xiao-Li Zou, Ke-Jun Guo, Yue Zhao, Chun-Yang Meng, Fei Yin, Li Guo
Cadmium is a highly toxic metal with widespread exposure to people that can cause tissue injuries that lack effective treatment. The aim of this project was to uncover whether bone marrow mesenchymal stem cells (BMSCs) can repair cadmium-induced rat testis injury and to explore the role of mitochondrial apoptosis in this process. To this end, 21 adult male Wistar rats were randomly divided into control, model and therapy groups, 7 each, and were administered 0, 0.4 and 0.4 mg/kg body weight CdCl2 saline solution, respectively, by intraperitoneal injection 5 times per week for 5 weeks...
April 27, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28456544/gastroprotective-effect-of-gamma-aminobutyric-acid-on-ethanol-induced-gastric-mucosal-injury
#17
Min Xie, Haihong Chen, Shaoping Nie, Wei Tong, Junyi Yin, Mingyong Xie
The present study aimed to investigate the gastroprotective effect of gamma-aminobutyric acid (GABA) on ethanol-induced gastric mucosal injury and gastric epithelial cells injury. Rats were divided into control group, vehicle group and GABA-treated group (10, 20 and 40 mg/kg/day). After GABA ingestion for 14 days, rats except the control group were given 1 mL pure ethanol by oral gavage in order to induce acute gastric mucosal lesion. The human gastric epithelial cell line GES-1 was incubated with GABA (100, 200 and 400 μM) for 24 h, followed by treatment with 8% ethanol for 3 h to induce cell injury...
April 26, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28456543/subchronic-toxicity-of-low-dose-propoxur-permethrin-and-their-combination-on-the-redox-status-of-rat-liver
#18
Pan Wang, Ming-Yuan Xu, Yu-Jie Liang, Hui-Ping Wang, Ying-Jian Sun, Ding-Xin Long, Yi-Jun Wu
Carbamates and pyrethroids are widely used pesticides. However, their joint toxicity at low doses with long-term exposure remains unknown. Therefore, we investigated the subchronic joint hepatotoxicity of the two representative pesticides within these two classes, i.e., propoxur (PR) and permethrin (PE) in rats. The male Wistar rats were orally treated with three different doses of PR, PE and their mixtures for 90 consecutive days. Liver weight, serum clinical chemistry parameters and histopathological changes were measured to access the hepatotoxicity...
April 26, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28455230/mangiferin-attenuates-blast-induced-traumatic-brain-injury-via-inhibiting-nlrp3-inflammasome
#19
Kaihua Fan, Jie Ma, Wenjing Xiao, Jingmin Chen, Juan Wu, Jiandong Ren, Jun Hou, Yonghe Hu, Jianwen Gu, Botao Yu
There is growing evidence that Mangiferin possess therapeutic benefit during neuroinflammation on various brain injury models due to its anti-inflammatory properties. It is reported that inflammatory plays a crucial role in the pathogenesis of secondary injury induced by the blast-induced traumatic brain injury (bTBI). However, the role of mangiferin in bTBI is yet to be studied. In our study, the potential effect of mangiferin in the duration of bTBI was examined first. Fortunately, the amelioration of cerebral cortex damage was found in rats suffering bTBI after mangiferin administration...
April 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28450041/investigating-the-potential-of-oxymatrine-as-a-psoriasis-therapy
#20
Qian Chen, Hui Zhou, Yinxue Yang, Mingwei Chi, Nan Xie, Hong Zhang, Xingwang Deng, David Leavesley, Huijuan Shi, Yan Xie
Psoriasis vulgaris is a chronic inflammatory skin disease, stubbornly intractable, with substantial consequences for patient physical and mental welfare. Approaches currently available to treat psoriasis are not satisfactory due to undesirable side-effects or expense. Psoriasis is characterized by hyperproliferation and inflammation. Oxymatrine, an active component extracted from Sophora flavescens, has been demonstrated to possess anti-proliferation, anti-inflammatory, anti-tumorigenic, immune regulation and pro-apoptotic properties...
April 25, 2017: Chemico-biological Interactions
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