journal
https://read.qxmd.com/read/38522565/astragalus-polysaccharides-ameliorates-experimental-colitis-by-regulating-memory-b-cells-metabolism
#1
JOURNAL ARTICLE
Yifei Deng, Lizhao Song, Jiaqi Huang, Wen Zhou, Yali Liu, Xiuyun Lu, Haimei Zhao, Duanyong Liu
It is well-established that the reduced Memory B cells (MBCs) play an important role in the pathogenesis of ulcerative colitis (UC), rendering them a potential therapeutic target for UC intervention. Astragalus polysaccharide (APS), a primary active constituent derived from the classic traditional Chinese medicine Astragalus membranaceus (AM), has been used for centuries in the treatment of UC in both human and animal subjects due to its renowned immunomodulatory properties. However, it is unknown whether APS can regulate MBCs to alleviate experimental colitis...
March 22, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38522564/morusin-inhibits-breast-cancer-induced-osteolysis-by-decreasing-phosphatidylinositol-3-kinase-pi3k-mtor-signalling
#2
JOURNAL ARTICLE
Long Zhang, Weibin Li, Xiaohui Chen, Dongmin Cao, Siyuan You, Fan Shi, Zhengqiong Luo, Hongyu Li, Xiangchen Zeng, Yabin Song, Na Li, Yoshie Akimoto, Gang Rui, Yu Chen, Zuoxing Wu, Ren Xu
Bone metastases caused by breast cancer pose a major challenge to the successful treatment of breast cancer patients. Many researchers have suggested that herbal medicines are extremely effective at preventing and treating cancer-associated osteolysis. Previous studies have revealed that Morusin (MOR) is cytotoxic to many cancer cells ex vivo. Nevertheless, how MOR contributes to osteolysis induced by breast cancer is still unknown, and the potential mechanism of action against osteolysis is worthy of further study...
March 22, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38522563/fluorescence-study-of-the-interaction-between-albumin-and-layered-double-hydroxides
#3
JOURNAL ARTICLE
Cecilia Vasti, Corina Marengo-Viada, Carla E Giacomelli, Ricardo Rojas
Layered double hydroxides nanoparticles (LDH-NP) are increasingly studied for biomedical applications. Nevertheless, their interaction with biomolecules such as proteins needs further exploration for an effective application. In this work, the adsorption of bovine serum albumin (BSA) on LDH-NP and the conformation changes of the protein upon adsorption were characterized using fluorescence spectroscopy. First, the quenching of tryptophan residues of BSA by chloride-intercalated LDH-NP was explored and the BSA adsorption capacity of LDH-NP were determined...
March 22, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38521455/from-gains-to-gaps-how-selective-androgen-receptor-modulator-sarm-yk11-impact-hippocampal-function-in-silico-in-vivo-and-ex-vivo-perspectives
#4
JOURNAL ARTICLE
Mustafa Munir Mustafa Dahleh, Vandreza Cardoso Bortolotto, Silvana Peterini Boeira, Hecson Jesser Segat, Gustavo Petri Guerra, Marina Prigol
Selective Androgen Receptor Modulators (SARMs), particularly (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic-acid-methyl-ester (YK11), are increasingly popular among athletes seeking enhanced performance. Serving as an Androgen Receptor (AR) agonist, YK11 stimulates muscle growth while inhibiting myostatin. Our study delved into the impact of YK11 on the rat hippocampus, analyzing potential alterations in neurochemical mechanisms and investigating its synergistic effects with exercise (EXE), based on the strong relationship between SARM users and regular exercise...
March 21, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38518852/thiazolyl-isatin-derivatives-synthesis-in-silico-studies-in-vitro-biological-profile-against-breast-cancer-cells-mrna-expression-p-gp-modulation-and-interactions-of-akt2-and-vim-proteins
#5
JOURNAL ARTICLE
Luiz Alberto Barros Freitas, Carolina Souza, Beatriz Silva Lima, Denise Duarte, Paulo André Teixeira de Moraes Gomes, Camila Gabriela Costa Ramos, Valécia de Cássia Mendonça Costa, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Carlos Alberto de Simone, Mafalda Videira, Ana Cristina Lima Leite
The literature reports that thiazole and isatin nuclei present a range of biological activities, with an emphasis on anticancer activity. Therefore, our proposal was to make a series of compounds using the molecular hybridization strategy, which has been used by our research group, producing hybrid molecules containing the thiazole and isatin nuclei. After structural planning and synthesis, the compounds were characterized and evaluated in vitro against breast cancer cell lines (T-47D, MCF-7 and MDA-MB-231) and against normal cells (PBMC)...
March 20, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38518851/selenium-binding-protein-1-protects-renal-tubular-epithelial-cells-from-ferroptosis-by-upregulating-glutathione-peroxidase-4
#6
JOURNAL ARTICLE
Weihao Zhao, David J Nikolic-Paterson, Ke Li, Yan Li, Yinhong Wang, Xianghui Chen, Zhaoyang Duan, Yuzhan Zhang, Pengfei Liu, Shemin Lu, Rongguo Fu, Lifang Tian
Ferroptosis is a form of programmed cell death involved in various types of acute kidney injury (AKI). It is characterized by inactivation of the selenoprotein, glutathione peroxidase 4 (GPX4), and upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4). Since urinary selenium binding protein 1 (SBP1/SELENBP1) is a potential biomarker for AKI, this study investigated whether SBP1 plays a role in AKI. First, we showed that SBP1 is expressed in proximal tubular cells in normal human kidney, but is significant downregulated in cases of AKI in association with reduced GPX4 expression and increased ACSL4 expression...
March 20, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38513930/oleanolic-acid-promotes-liver-regeneration-after-partial-hepatectomy-via-regulating-pregnane-x-receptor-signaling-pathway-in-mice
#7
JOURNAL ARTICLE
Shaofei Song, Hong Peng, Yuan Li, Tingting Zhao, Renjie Cao, Lei Zheng, Min Huang, Yiming Jiang
Liver regeneration after liver tumor resection or liver transplantation is crucial, the remaining liver frequently fails to regenerate in some patients. Oleanolic acid (OA), a pentacyclic triterpenoid compound which has been shown to protect against various liver diseases. However, the effect of OA on liver regeneration after partial hepatectomy (PHx) is still unclear. In this study, the results showed that OA (50 mg/kg, twice daily) treatment induced liver mass restoration and increased the liver-to-body weight ratio of mice following PHx...
March 19, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38513929/activation-of-alpha-7-nicotinic-acetylcholine-receptor-by-tropisetron-mitigates-3-nitropropionic-acid-induced-huntington-s-disease-in-rats-role-of-pi3k-akt-and-jak2-nf-%C3%AE%C2%BAb-signaling-pathways
#8
JOURNAL ARTICLE
Mostafa A Rabie, Ahmed T Ghoneim, Mohamed I Fahmy, Mohammed F El-Yamany, Rabab H Sayed
Huntington's disease (HD) is an inheritable autosomal-dominant disorder that targets mainly the striatum. 3-Nitropropionic acid (3-NP) induces obvious deleterious behavioral, neurochemical, and histological effects similar to the symptoms of HD. Our study aimed to examine the neuroprotective activity of tropisetron, an alpha-7 neuronal nicotinic acetylcholine receptor (α-7nAChR) agonist, against neurotoxic events associated with 3-NP-induced HD in rats. Forty-eight rats were randomly allocated into four groups...
March 19, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38493911/crabp2-reduces-the-sensitivity-of-olaparib-in-ovarian-cancer-by-downregulating-caspase-8-and-decreasing-the-production-of-reactive-oxygen-species
#9
JOURNAL ARTICLE
Shuangshuang Zeng, Zhijie Xu, Yuanhong Liu, Shangjun Zhou, Yuanliang Yan
Poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors, such as Olaparib, have been pivotal in treating BRCA-deficient ovarian cancer. However, their efficacy is limited in over 40% of BRCA-deficient patients, with acquired resistance posing new clinical challenges. To address this, we employed bioinformatics methods to identify key genes impacting Olaparib sensitivity in ovarian cancer. Through comprehensive analysis of public databases including GEO, CPTAC, Kaplan Meier Plotter, and CCLE, we identified CRABP2 as significantly upregulated at both mRNA and protein levels in ovarian cancer, correlating with poor prognosis and decreased Olaparib sensitivity...
March 15, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38493910/uncharged-mono-and-bisoximes-in-search-of-a-zwitterion-to-countermeasure-organophosphorus-intoxication
#10
JOURNAL ARTICLE
Lukas Gorecki, Aneta Markova, Vendula Hepnarova, Natalie Zivna, Lucie Junova, Martina Hrabinova, Jiri Janousek, Tereza Kobrlova, Lukas Prchal, Daniel Jun, Ondrej Soukup, Gabriele Horn, Franz Worek, Jan Marek, Jan Korabecny
The current study imposes a new class of organophosphorus (OP)-inhibited cholinesterase reactivators by conceptualizing a family of asymmetric bisoximes with various reactivating scaffolds. Several novel nucleophilic warheads were investigated, putting forward 29 novel reactivating options, by evaluating their nucleophilicity and ability to directly decompose OP compounds. Adopting the so-called zwitterionic strategy, 17 mono-oxime and nine bisoxime reactivators were discovered with major emphasis on the bifunctional-moiety approach...
March 15, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38492842/aucubin-produces-anti-osteoporotic-effects-under-mechanical-stretch-stress-and-orthodontic-tooth-movement
#11
JOURNAL ARTICLE
Jiamiao Huang, Huan Jiang, Haoyu Wang, Qing Xue, Min Hu, Yutong Li
Aucubin (AU), an iridoid glycoside extracted from Eucommia ulmoides, exerts anti-osteoporotic effects by promoting osteogenesis, as reported in previous studies. Here, we investigated the effects of AU under mechanical stretch stress. MC3T3-E1 cells were treated with dexamethasone (DEX) in vitro and subjected to mechanical stretch stress to establish an osteoporotic orthodontic force cell model. AU treatment increased the mRNA and protein expressions of BMP2, OPN, RUNX2, COL-1 and other osteogenic differentiation factors in MC3T3-E1 cells...
March 14, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38490643/quercetin-attenuates-cisplatin-induced-mitochondrial-apoptosis-via-pi3k-akt-mediated-inhibition-of-oxidative-stress-in-pericytes-and-improves-the-blood-labyrinth-barrier-permeability
#12
JOURNAL ARTICLE
Tian-Lan Huang, Wen-Jun Jiang, Zan Zhou, Tian-Feng Shi, Miao Yu, Meng Yu, Jun-Qiang Si, Yan-Ping Wang, Li Li
Cisplatin (CDDP) is broadly employed to treat different cancers, whereas there are no drugs approved by the Food and Drug Administration (FDA) for preventing its side effects, including ototoxicity. Quercetin (QU) is a widely available natural flavonoid compound with anti-tumor and antioxidant properties. The research was designed to explore the protective effects of QU on CDDP-induced ototoxicity and its underlying mechanisms in male C57BL/6 J mice and primary cultured pericytes (PCs). Hearing changes, morphological changes of stria vascularis, blood labyrinth barrier (BLB) permeability and expression of apoptotic proteins were observed in vivo by using the auditory brainstem response (ABR) test, HE staining, Evans blue staining, immunohistochemistry, western blotting, etc...
March 13, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38484827/toxicity-of-minoxidil-comprehensive-in-silico-prediction-of-main-toxicity-endpoints-acute-toxicity-irritation-of-skin-and-eye-genetic-toxicity-health-effect-cardiotoxicity-and-endocrine-system-disruption
#13
JOURNAL ARTICLE
Adrian Frydrych, Kamil Jurowski
This article focusses on elucidating the toxicological profile of minoxidil, a widely used pharmacological agent for alopecia, through the application of in silico methods (Percepta ACD/Labs software). This research is driven by the need to understand key toxicological endpoints: acute toxicity, skin and eye irritation, genetic toxicity, cardiotoxicity, disruption of the endocrine system, and estimation of various health effects due to the lack of experimental data for this drug. These parameters are critically evaluated to meet the stringent requirements of the pharmaceutical industry's safety assessments...
March 12, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38484826/aldo-keto-reductase-7a2-protects-against-atorvastatin-induced-hepatotoxicity-via-nrf2-activation
#14
JOURNAL ARTICLE
Dan Li, Jiajin Chen, Fei Zhou, Wenhe Zhang, Hongyu Chen
Atorvastatin (ATO), as a cholesterol-lowering drug, was the world's best-selling drug in the early 2000s. However, ATO overdose-induced liver or muscle injury is a threat to many patients, which restricts its application. Previous studies suggest that ATO overdose is accompanied with ROS accumulation and increased lipid peroxidation, which are the leading causes of ATO-induced liver damage. This study is, therefore, carried out to investigate the roles of anti-oxidant pathways and enzymes in protection against ATO-induced hepatotoxicity...
March 12, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38484825/rosamultin-ameliorates-radiation-injury-via-promoting-dna-injury-repair-and-suppressing-oxidative-stress-in-vitro-and-in-vivo
#15
JOURNAL ARTICLE
Ning Liu, Mengxin Niu, Saiyan Luo, Lijuan Lv, Xiaoxiao Quan, Chang Wang, Zhiyun Meng, Jingquan Yuan, Qiongming Xu, Yanli Liu
Radiotherapy remains the preferred treatment option for cancer patients with the advantages of broad indications and significant therapeutic effects. However, ionizing radiation can also damage normal tissues. Unfortunately, there are few anti-radiation damage drugs available on the market for radiotherapy patients. Our previous study showed that rosamultin had antioxidant and hepatoprotective activities. However, its anti-radiation activity has not been evaluated. Irradiating small intestinal epithelial cells and mice with whole-body X-rays radiation were used to evaluate the in vitro and in vivo effects of rosamultin, respectively...
March 12, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38479716/design-synthesis-and-mechanism-study-of-coumarin-sulfonamide-derivatives-as-carbonic-anhydrase-ix-inhibitors-with-anticancer-activity
#16
JOURNAL ARTICLE
Qianqian Lv, Jing Zhang, Jianghong Cai, Lexian Chen, Jiajie Liang, Tianwan Zhang, Jiahui Lin, Ruiyao Chen, Zhiling Zhang, Peiting Guo, Yue Hong, Lingxue Pan, Hong Ji
In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are original were designed and synthesized. Cytotoxicity assay indicated that most of these derivatives exhibited moderated to good potency against A549 cells. Among them, compound 8q showed potent inhibition against the four tested cancer cell lines, especially A549 cells with IC50 value of 6.01 ± 0.81 μM, and much lower cytotoxicity on the normal cells was observed compared to the reference compounds...
March 11, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38479715/the-mechanism-of-anthracene-degradation-by-tryptophan-2-3-dioxygenase-t23d-in-comamonas-testosterone
#17
JOURNAL ARTICLE
Miao Xu, Xiao Yang, Jinyuan Zhang, Dong Liu, Chuanzhi Zhang, Ming Wu, Elshan Musazade, Edmund Maser, Guangming Xiong, Liquan Guo
It is well known that anthracene is a persistent organic pollutant. Among the four natural polycyclic aromatic hydrocarbons (PAHs) degrading strains, Comamonas testosterone (CT1) was selected as the strain with the highest degradation efficiency. In the present study, prokaryotic transcriptome analysis of CT1 revealed an increase in a gene that encodes tryptophane-2,3-dioxygenase (T23D) in the anthracene and erythromycin groups compared to CK. Compared to the wild-type CT1 strain, anthracene degradation by the CtT23D knockout mutant (CT-M1) was significantly reduced...
March 11, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38479714/new-ca-2-based-anticancer-nanomaterials-trigger-multiple-cell-death-targeting-ca-2-homeostasis-for-cancer-therapy
#18
REVIEW
Junjie Liu, Yimin Xie, Jun Ma, Hezhen Chu
Calcium ion (Ca2+ ) is a necessary element for human and Ca2+ homeostasis plays important roles in various cellular process and functions. Recent reaches have targeted on inducing Ca2+ overload (both intracellular and transcellular) for tumor therapy. With the development of nanotechnology, nanoplatform-mediated Ca2+ overload has been safe theranostic model for cancer therapy, and defined a special calcium overload-induced tumor cell death as "calcicoptosis". However, the underlying mechanism of calcicoptosis in cancer cells remains further identification...
March 11, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38471628/protective-role-of-forsythoside-b-in-kawasaki-disease-induced-cardiac-injury-inhibition-of-pyroptosis-via-the-sirt1-nf-%C3%AE%C2%BAb-p65-signaling-pathway
#19
JOURNAL ARTICLE
Yitong Yang, Nisha Wang, Zhenyi Wang, Miaomiao Zhao, Luping Chen, Zhaoling Shi
Kawasaki disease (KD), an acute exanthematous febrile pediatric illness involving systemic non-specific inflammatory reactions in small- and medium-sized arteries, poses a significant risk of coronary artery and myocardial inflammatory injury. Developing new KD treatments with improved safety and fewer side-effects is highly desirable. Forsythoside B (FTS-B), extracted from the Forsythia suspensa plant, exerts anti-inflammatory activity by inhibiting NF-κB, which is regulated by SIRT1, the reduced expression of which is strongly associated with cardiovascular disease...
March 10, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38467339/a-systematic-review-on-understanding-the-mechanistic-pathways-and-clinical-aspects-of-natural-cdk-inhibitors-on-cancer-progression-unlocking-cellular-and-biochemical-mechanisms
#20
REVIEW
Andleeb Asghar, Tahir Ali Chohan, Umair Khurshid, Hammad Saleem, Mian Waqar Mustafa, Anjum Khursheed, Ahmed Alafnan, Rahila Batul, Mohammed Khaled Bin Break, Khaled Almansour, Sirajudheen Anwar
Cell division, differentiation, and controlled cell death are all regulated by phosphorylation, a key biological function. This mechanism is controlled by a variety of enzymes, with cyclin-dependent kinases (CDKs) being particularly important in phosphorylating proteins at serine and threonine sites. CDKs, which contain 20 unique components, serve an important role in regulating vital physiological functions such as cell cycle progression and gene transcription. Methodologically, an extensive literature search was performed using reputable databases such as PubMed, Google Scholar, Scopus, and Web of Science...
March 9, 2024: Chemico-biological Interactions
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