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Chemico-biological Interactions

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https://www.readbyqxmd.com/read/29339219/caffeine-supplemented-diet-modulates-oxidative-stress-markers-and-improves-locomotor-behavior-in-the-lobster-cockroach-nauphoeta-cinerea
#1
Cícera Simoni da Silva, Rita de Cássia Gonçalves de Lima, Olusola Olalekan Elekofehinti, Yetunde Ogunbolude, Antonia Eliene Duarte, João Batista Teixeira Rocha, Irwin Rose Alencar de Menezes, Luiz Marivando Barros, Appolinaire Tsopmo, Kiven Erique Lukong, Jean Paul Kamdem
The effects of caffeine supplementation is well documented in conventional animal models, however the effects in the lobster cockroaches Nauphoeta cinerea have not been reported. Thus, we aimed to investigate the locomotor behavior and biochemical endpoints in the head of the nymphs of N. cinerea following 60 days exposure to food supplemented with 0, 0.5, 1.0, 2.5, 5.0 and 10.0 mg of caffeine/g of diet. The analysis of the locomotor behavior using the video-tracking software, Any-maze, for 12 min revealed that caffeine supplementation caused significant behavioral improvement...
January 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29339218/protective-effect-of-patchoulene-epoxide-against-ethanol-induced-gastric-ulcer-in-rats-influence-on-oxidative-stress-inflammation-and-apoptosis
#2
Jiali Liang, Yaoxing Dou, Xue Wu, Huilin Li, Jiazhen Wu, Qionghui Huang, Dandan Luo, Tiegang Yi, Yuhong Liu, Ziren Su, Jianping Chen
Patchoulene epoxide (PAO), a tricyclic sesquiterpene isolated from the long-strored patchouli oil, has been demonstrated the anti-inflammatory activity in vivo based on our previous study. However, the gastroprotective effect of PAO still remains unknown. Therefore, in the present study, ethanol-induced gastric ulcer in rats was carried out to evaluate the anti-ulcerogenic activity of PAO and to elucidate the potential mechanisms that involved. According to our results, macroscopic examination revealed that pre-treatment with PAO signficantly reduced ethanol-induced gastric ulcer areas as compared with the vehicle group, which was also supported by histological evaluation...
January 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29339217/effects-of-rutin-on-the-physicochemical-properties-of-skin-fibroblasts-membrane-disruption-following-uv-radiation
#3
Izabela Dobrzyńska, Agnieszka Gęgotek, Ewelina Gajko, Elżbieta Skrzydlewska, Zbigniew A Figaszewski
Human skin provides the body's first line of defense against physical and environmental assaults. This study sought to determine how rutin affects the membrane electrical properties, sialic acid content, and lipid peroxidation levels of fibroblast membranes after disruption by ultraviolet (UV) radiation. Changes in cell function may affect the basal electrical surface properties of cell membranes, and changes can be detected by electrokinetic measurements. The charge density of the fibroblast membrane surface was measured as a function of pH...
January 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29336987/the-in-vitro-radiosensitizer-potential-of-resveratrol-on-mcf-7-breast-cancer-cells
#4
Isabel Cristina da Costa Araldi, Fernando Primitivo Romero Bordin, Francine Carla Cadoná, Fernanda Barbisan, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Tadeu Baumhardt, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte, Liliane de Freitas Bauermann
Radiation therapy is commonly applied in breast cancer (BC) patients. However, radioresistance and side effects are limiting factors of this practice. Therefore, studying substances that can enhance the radiation effect and, at the same time, protect normal cells is very relevant. Thus, the aim of this work was to assess the radiosensitizer effect of resveratrol (RV) on BC cells (MCF-7). A high cytotoxic and antiproliferative effect was observed in the treatment with 10 μM of RV + 3 Gy ionizing radiation (IR)...
January 11, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29331654/in-vitro-and-in-vivo-metabolic-activation-of-rhein-and-characterization-of-glutathione-conjugates-derived-from-rhein
#5
Yang Xu, Xu Mao, Boyang Qin, Ying Peng, Jiang Zheng
Rhein (RH), 4,5-dihydroxyanthrauinone-2-carboxylic acid, is found in rhubarb (Dahuang), a traditional herbal medicine. RH has reportedly demonstrated multiple pharmacologic properties. Previous studies have also shown that RH induced hepatotoxicity, but the mechanisms of the adverse effect remain unknown. The major objective of the present study was to study the metabolic pathways of RH in order to identify potential reactive metabolites. One mono-hydroxylation metabolite (M1) was detected in urine and bile of rats given RH...
January 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29331653/gallic-acid-attenuates-type-i-diabetic-nephropathy-in-rats
#6
Mayuresh Sudamrao Garud, Yogesh Anant Kulkarni
Literatures suggest that TGF-β1 have a central role in the progression of diabetic nephropathy and its down regulation can improve the disease condition. Oxidative stress, generation of advanced glycation end products and activation of renin angiotensin system are the connecting links between hyperglycemia and TGF-β1 over expression. Gallic acid is a phytochemical having wide range of biological activities. Gallic acid is reported to have antioxidant and advanced glycation inhibitory activity. It has also shown inhibitory effects on angiotensin converting enzyme...
January 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29331652/salinomycin-induces-primary-chicken-cardiomyocytes-death-via-mitochondria-mediated-apoptosis
#7
Xiuge Gao, Yani Zheng, Xiangchun Ruan, Hui Ji, Lin Peng, Dawei Guo, Shanxiang Jiang
Salinomycin, as a polyether ionophore antibiotic, is extensively used as a feed additive against coccidiosis in poultry and as a growth promoter of ruminants worldwide. Owing to its narrow therapeutic index, numerous intoxication have been reported in target/non-target animals by overdosage, misuse or drug interactions as well as human who consumed salinomycin accidently. Salinomycin-induced cardiotoxicity in chicken and non-target animals is considered as a major contributor to animal death. In the current study, we aim to elucidate the underlying mechanism of its myocardial toxicity using primary chicken myocardial cell as an in vitro model...
January 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29331651/activation-of-p62-keap1-nrf2-antioxidant-pathway-in-the-early-stage-of-acetaminophen-induced-acute-liver-injury-in-mice
#8
Zhenyu Shen, Yu Wang, Zhenhui Su, Ruirui Kou, Keqin Xie, Fuyong Song
Acetaminophen (APAP) overdose can cause severe liver failure even death. Nearly half of drug-induced liver injury is attributed to APAP in the US and many European countries. Oxidative stress has been validated as a critical event involved in APAP-induced liver failure. p62/SQSTM1, a selective autophagy adaptor protein, is reported to regulate Nrf2-ARE antioxidant pathway in response to oxidative stress. However, the exact role of p62-keap1-Nrf2 antioxidant pathway in APAP-induced hepatotoxicity remains unknown...
January 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29329665/bioactivation-of-1-chloro-2-hydroxy-3-butene-an-in-vitro-metabolite-of-1-3-butadiene-by-rat-liver-microsomes
#9
Ye Wang, Ying-Xin Yu, Yang Luan, Jing An, Dong-Guang Yin, Xin-Yu Zhang
1-Chloro-2-hydroxy-3-butene (CHB) is an in vitro metabolite of 1,3-butadiene, a rodent/human carcinogen. To search for an approach detecting CHB in vivo, it is vital to obtain a full understanding of CHB metabolism. Previously, we demonstrated that CHB was bioactivated to 1-chloro-3-buten-2-one (CBO) by alcohol dehydrogenase. However, CHB metabolism by cytochrome P450s has not been reported. Thus, in the present study, CHB metabolism by rat liver microsomes was investigated. The results showed that CHB was converted to 1-chloro-3,4-epoxy-2-butanol (CEB) and CBO...
January 9, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29325850/interaction-of-dna-with-water-soluble-complex-of-nickle-and-formation-of-dna-cross-links
#10
Maryam Nejat Dehkordi, Bjorn Akerman
Interaction of double stranded DNA with bulky and hydrophobic Salen type Schiff base complex: [N, N' Bis [3- tert-butyl-5-[triphenyl-phosphonium - methyl] - salicylidene] 1,2 ethylene-diamine nickel(III) acetate (refer to Ni Salen complex) was extensively investigated using the spectroscopic techniques and gel electrophoresis. Absorption titration experiment showed the hypochromic effect and the significant red shift of the complex absorption. In competition experiments with ethidium bromide (EB), Ni Salen complex exhibited non-competitive binding at high concentrations...
January 8, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29325849/coagonist-of-glp-1-and-glucagon-decreases-liver-inflammation-and-atherosclerosis-in-dyslipidemic-condition
#11
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Dhreerendra Pandey, Hiren Patel, Ramchandra Ranvir, Shekhar Kadam, Dipam Patel, Rajesh Bahekar, Mukul Jain
Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and hepatic lipids, independent of its anorexic effects. Here, we investigated the role of coagonist of GLP-1 and glucagon receptors in complications of diet-induced dyslipidemia in hamsters and humanized double transgenic mice. Hamsters fed on high fat high cholesterol diet were treated for 8 weeks with coagonist of GLP-1 and glucagon receptors (75 and 150 μg/kg)...
January 8, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29317251/organoselenium-group-is-critical-for-antioxidant-activity-of-7-chloro-4-phenylselenyl-quinoline
#12
Ane G Vogt, Guilherme T Voss, Renata L de Oliveira, Jaini J Paltian, Luis F B Duarte, Diego Alves, Cristiano R Jesse, Silvane S Roman, Juliano A Roehrs, Ethel A Wilhelm, Cristiane Luchese
The quinolone compounds have been reported for many biological properties, especially as potent antioxidants. This study investigated the antioxidant effect of 7-chloro-4-phenylselenyl-quinoline (PSQ), a quinolone derivative with organoselenium group, against oxidative stress induced by sodium nitroprusside (SNP) in brains of mice. A second objective was to verify the importance of phenylselenyl group presents at position 4 of the quinoline structure to antioxidant effect of compound. So, it was compared the antioxidant effect of PSQ with a quinoline without organoseleniun group (7-chloroquinoline [QN])...
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29317250/arctigenin-protects-against-ultraviolet-a-induced-damage-to-stemness-through-inhibition-of-the-nf-%C3%AE%C2%BAb-mapk-pathway
#13
See-Hyoung Park, Jae Youl Cho, Sae Woong Oh, Mingyeong Kang, Seung Eun Lee, Ju Ah Yoo, Kwangseon Jung, Jienny Lee, Sang Yeol Lee, Jongsung Lee
The stemness of stem cells is negatively affected by ultraviolet A (UVA) irradiation. This study was performed to examine the effects of arctigenin on UVA-irradiation-induced damage to the stemness of human mesenchymal stem cells (hMSCs) derived from adipose tissue. The mechanisms of action of arctigenin were also investigated. A BrdU-incorporation assay demonstrated that arctigenin attenuated the UVA-induced reduction of the cellular proliferative potential. Arctigenin also increased the UVA-induced reduction in stemness of hMSCs by upregulating stemness-related genes such as SOX2, OCT4, and NANOG...
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29317249/mechanisms-of-2-3-7-8-tetrachlorodibenzo-p-dioxin-induced-cardiovascular-toxicity-an-overview
#14
REVIEW
Mahdieh Sadat Mohsenzadeh, Bamdad Riahi Zanjani, Gholamreza Karimi
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of TCDD cardiovascular toxicity consist of oxidative stress, growth factor modulation, and ionic current alteration. It is indicated that the rodent cardiovascular system is a target for TCDD cardiomyopathy. Here, our understanding of TCDD cardiovascular toxicity is reviewed.
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29291386/nifuroxazide-a-stat3-inhibitor-mitigates-inflammatory-burden-and-protects-against-diabetes-induced-nephropathy-in-rats
#15
Eman Said, Sawsan A Zaitone, Mohamed Eldosoky, Nehal M Elsherbiny
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. Moreover,it is amongst the most common causes of end-stage renal failure. Inflammation is a crucial player in both development and progression of DN. JAK2/STA3 is a pleotropic cascade reported to regulate diverse inflammatory events. Previous studies reported involvement of JAK2/STA3 signal transduction pathway in diabetes-associated renal injury. In the current study, the inhibitory effect of nifuroxazide (25 mg/kg/day, orally) against inflammatory condition associating diabetic kidney progression in rats was evaluated...
December 29, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29289488/protective-effects-of-zingerone-on-lipopolysaccharide-induced-hepatic-failure-through-the-modulation-of-inflammatory-pathways
#16
Wonhwa Lee, Mi-Hye Hwang, Yuri Lee, Jong-Sup Bae
The aim of this study was to investigate the effects of zingerone (ZGR) on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate underlying mechanisms. ZGR is a phenolic alkanone isolated from ginger, and has potential health benefits. Mice were treated intravenously with ZGR at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by ZGR...
December 28, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29277637/synthesis-and-characterisation-of-arsenic-nanoparticles-and-its-interaction-with-dna-and-cytotoxic-potential-on-breast-cancer-cells
#17
A Subastri, V Arun, Preeti Sharma, E Preedia Babu, A Suyavaran, S Nithyananthan, Ghedeir M Alshammari, B Aristatile, V Dharuman, C Thirunavukkarasu
Therapeutic applications of arsenic trioxide (ATO) are limited due to their severe adverse effects. However, nanoparticles of ATO might possess inimitable biologic effects based on their structure and size which differ from their parent molecules. Based on this conception, AsNPs were synthesized from ATO and comparatively analysed for their interaction mechanism with DNA using spectroscopic & electrochemical techniques. Finally, anti-proliferative activity was assessed against different breast cancer cells (MDA-MB-231 & MCF-7) and normal non-cancerous cells (HEK-293)...
December 22, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29275087/gas-chromatography-mass-spectrometry-metabolomic-study-of-lipopolysaccharides-toxicity-on-rat-basophilic-leukemia-cells
#18
Fangchao Cui, Pei Zhu, Jian Ji, Ivana Blaženović, Morteza Gholami, Yinzhi Zhang, Xiulan Sun
Lipopolysaccharide (LPS) can lead to uncontrollable cytokine production, fatal sepsis syndrome and depression/multiple organ failure, as pathophysiologic demonstration. Various toxic effects of LPS have been extensively reported, mainly on the toxicity of LPS in cellular level, macrophages or tumor cells, etc. This work aimed on the impact of LPS on mast cell metabolism, which focused on LPS-induced cellular metabolic profiles. Gas chromatography-mass spectrometry (GC-MS) based metabolomics strategy was implemented for the endo-metabolites detection in rat basophilic leukemia (RBL-2H3) cells, treated with 10 μg/mL LPS for 24 h, along with multiple time-dose tests of cells viability/apoptosis...
December 21, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29274324/apoptosis-induction-and-inhibition-of-hela-cell-proliferation-by-alpha-naphthoflavone-and-resveratrol-are-aryl-hydrocarbon-receptor-independent
#19
Alegre Flores-Pérez, Guillermo Elizondo
Human papilloma viruses 16 and 18 express E6 and E7 oncoproteins. E6 activates and redirects E6-associated protein (E6AP), an E3 ubiquitin ligase. E6AP interacts with Ube2l3, an E2 ubiquitin conjugating enzyme protein (also known as UbcH7), to promote p53 ubiquitination and degradation by the 26S proteasome. Therefore, blocking E6-mediated p53 degradation might be an alternative treatment for cervical cancer. In addition, activation of the aryl hydrocarbon receptor (AHR) induces Ube2l3 expression, resulting in p53 ubiquitination and degradation...
December 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29273567/1-hydroxy-3-e-4-piperazine-diium-but-2-enyloxy-9-10-anthraquinone-ditrifluoroactate-induced-autophagic-cell-death-in-human-pc3-cells
#20
A-Mei Huang, Kai-Wei Lin, Wei-Hong Lin, Li-Hung Wu, Hao-Chun Chang, Chujun Ni, Danny Ling Wang, Hsue-Yin Hsu, Chun-Li Su, Chiaho Shih
The autophagy of human prostate cancer cells (PC3 cells) induced by a new anthraquinone derivative, 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate (PA) was investigated, and the relationship between autophagy and reactive oxygen species (ROS) generation was studied. The results indicated that PA induced PC3 cell death in a time- and dose-dependent manner, could inhibit PC3 cell growth by G1 phase cell cycle arrest and corresponding decrease in the G2/M cell population and induced S-phase arrest accompanied by a significant decrease G2/M and G1 phase numbers after PC3 cells treated with PA for 48 h, and increased the accumulation of autophagolysosomes and microtubule-associated protein LC3-ll, a marker of autophagy...
December 19, 2017: Chemico-biological Interactions
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