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Hormones and Behavior

Ann Z Bauer, David Kriebel, Martha R Herbert, Carl-Gustaf Bornehag, Shanna H Swan
BACKGROUND: The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. OBJECTIVES: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. METHODS: Relevant sources were identified through a key word search of multiple databases (Medline, CINAHL, OVID and TOXNET) in September 2016...
January 13, 2018: Hormones and Behavior
Shu-Chen Chu, Pei-Ni Chen, Jeng-Rung Chen, Ching-Han Yu, Yih-Shou Hsieh, Dong-Yih Kuo
Leptin is an adipose tissue hormone which plays an important role in regulating energy homeostasis. Amphetamine (AMPH) is a drug of appetite suppressant, which exerts its effect by decreasing the expression of hypothalamic neuropeptide Y (NPY) and increasing that of cocaine- and amphetamine-regulated transcript (CART). This study investigated whether leptin, the leptin receptor (LepRb) and the signal transducer and activator of transcription-3 (STAT3) were involved in NPY/CART-mediated appetite suppression in AMPH-treated rats...
January 4, 2018: Hormones and Behavior
Veronika Engert, Amy M Ragsdale, Tania Singer
In laboratory environments individuals may display empathic cortisol stress responses merely from observing another experience psychosocial stress. Moreover, within couples, women synchronize their own to their partners' cortisol release. We investigated whether a woman's tendency to experience such cortisol stress resonance in a controlled laboratory task is associated with the degree to which her and her partner's diurnal cortisol levels covary in a naturalistic environment. Such habitual cortisol covariation may be a pathway via which close relationships influence health outcomes...
January 4, 2018: Hormones and Behavior
Michael B Hennessy, W Tang Watanasriyakul, Brittany C Price, Alexander S Bertke, Patricia A Schiml
In the guinea pig, the presence of the mother buffers hypothalamic-pituitary-adrenal (HPA) responses of her young during exposure to a novel environment, and can do so even if she is anesthetized. In contrast, under comparable conditions other conspecifics (siblings, other adult females) are less effective or ineffective in doing so. However, we recently observed that an unfamiliar adult male reduced plasma cortisol elevations and increased Fos in the prefrontal cortex of preweaning pups exposed to a novel enclosure for 120min...
January 4, 2018: Hormones and Behavior
Ricardo P Vaz, Armando Cardoso, Paula Serrão, Pedro A Pereira, M Dulce Madeira
A recent study reported that the integrity of the nucleus of the lateral olfactory tract (nLOT) is required for normal olfaction and for the display of odor-driven behaviors that are critical for species survival and reproduction. In addition to being bi-directionally connected with a key element of the neural circuitry that mediates stress response, the basolateral nucleus of the amygdala, the nLOT is a potential target for glucocorticoids as its cells express glucocorticoid receptors. Herein, we have addressed this hypothesis by exploring, first, if chronic variable stress (CVS) disrupts odor detection and discrimination, and innate olfactory-driven behaviors, namely predator avoidance, sexual behavior and aggression in male rats...
January 4, 2018: Hormones and Behavior
Elisa R Hilderbrand, Amy W Lasek
Alcohol use disorder (AUD) manifests differently in men and women, but little is known about sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β-estradiol (E2) regulates voluntary ethanol consumption in female rodents. However, the role of E2 as a regulator of ethanol reward has not been investigated. In this study, we tested for the effects of E2 and agonists selective for the classical estrogen receptors, ERα and ERβ, on ethanol reward in ovariectomized (OVX) mice using the conditioned place preference (CPP) test...
January 3, 2018: Hormones and Behavior
Jacques Balthazart, Elena Choleris, Luke Remage-Healey
This brief commentary reviews key steps in the history of endocrinology that have resulted in important conceptual shifts. Our understanding of the "Fast Effects of Steroids" has now made substantial progress, including the major concept that steroids act rapidly on a variety of physiological and behavioral responses, via mechanisms that are too fast to be fully accounted for by classical receptor-dependent regulation of gene transcription. Several so-called 'non-classical' mechanisms have been identified and include binding to membrane receptors and regulating non genomic signaling cascades...
January 3, 2018: Hormones and Behavior
Stephanie F Thompson, Maureen Zalewski, Cara J Kiff, Liliana J Lengua
This study examined state-trait models of diurnal cortisol (morning level and diurnal slope), and whether income, cumulative risk and parenting behaviors predicted variance in trait and state levels of cortisol. The sample of 306 mothers and their preschool children included 29% families at or near poverty, 27% families below the median income, and the remaining families at middle and upper income. Diurnal cortisol, income, cumulative risk, and parenting were measured at 4 time points, once every 9months, starting when children were 36-40months...
January 3, 2018: Hormones and Behavior
Nia Fogelman, Turhan Canli
Given the high prevalence of early life stress (ELS) and the potential physiological dysregulation such experiences can lead to, this meta-analysis tested the relationship between ELS and cortisol. Search terms related to ELS and cortisol were entered in to PsycINFO and PubMed. Effect sizes were extracted for four outcomes variables: cortisol awakening response (CAR), baseline cortisol (cortisol at one time point), non-stressed cortisol over time (cortisol captured at two or more time points), and cortisol reactivity to an acute stressor...
December 28, 2017: Hormones and Behavior
Kathryn L G Russart, Danielle Huk, Randy J Nelson, Lawrence S Kirschner
Alterations in circulating thyroid hormone concentrations are associated with several psychological and behavioral disorders. In humans, behavioral disorders such as anxiety, depression, and attention-deficit hyperactivity disorder can be associated with thyroid disease. The Tpo-Cre;Prkar1aflox/flox;Epac1-/- (R1A-Epac1KO) mice, originally bred to investigate the role of exchange protein directly activated by cAMP (Epac1) in follicular thyroid cancer, displayed self-mutilating and aggressive behaviors during casual observation...
December 28, 2017: Hormones and Behavior
Michaela Pfundmair, Anne Rimpel, Korrina Duffy, Clarissa Zwarg
Previous research has shown an inconsistent pattern of how oxytocin (OT) affects the distinction between self and others: whereas one line of studies has revealed that OT blurs the self-other distinction, other studies have not. In an attempt to solve these inconsistencies, we hypothesized that OT blurs the boundary between self and other implicitly but not explicitly. To test this assumption, we used two experimental approaches. After participants intranasally self-administered OT or placebo, they were eye-tracked while conducting a prediction task (Study 1) or they were video-recorded while conducting a distraction task with a human counterpart (Study 2)...
December 28, 2017: Hormones and Behavior
Alex S Kowalczyk, Randy F Davila, Brian C Trainor
Male parental care is an important social behavior for several mammalian species. Psychosocial stress is usually found to inhibit maternal behavior, but effects on paternal behavior have been less consistent. We tested the effects of social defeat stress on pair bond formation and paternal behavior in the monogamous California mouse (Peromyscus californicus). Social defeat reduced time spent in a chamber with a stranger female during a partner preference test conducted 24h after pairing, but increased latency to the first litter...
December 28, 2017: Hormones and Behavior
Julia Loshchagina, Arseny Tsvey, Sergey Naidenko
During spring and autumn migrations, birds undergo a suite of physiological and behavioral adaptations known as migratory disposition. The position of migratory seasons within the annual cycle and specifics of environmental conditions in each season could lead to formation of specific regulatory mechanisms of spring and autumn migratory disposition. However, this topic remains largely unstudied. Here we compared corticosterone (CORT) concentration (baseline and stress-induced) in European robins (Erithacus rubecula) captured during seven consecutive migratory seasons on the Courish Spit in the Baltic Sea; >650 plasma samples were analyzed in total...
December 27, 2017: Hormones and Behavior
Xiao-Ming Xu, Qing-Sheng Chi, Jing Cao, Zhi-Jun Zhao
Aggression can benefit individuals by enhancing their dominance and thereby their ability to acquire and retain resources that increase survival or fitness. Engaging in aggressive behavior costs energy and how animals manage their energy budget to accommodate aggression remains unclear. We conducted three experiments to examine changes in physiological, behavioral and hormonal markers indicative of energy budget in male striped hamsters subject to resident-intruder aggression tests. Body temperature, metabolic rate and serum corticosterone levels significantly increased in resident hamsters immediately after the introduction of intruders...
December 27, 2017: Hormones and Behavior
Kristina O Smiley, Elizabeth Adkins-Regan
Parental care is a widespread phenomenon observed in many diverse taxa. Neuroendocrine systems have long been thought to play an important role in stimulating the onset of parental behavior. In most birds with altricial young, circulating prolactin (PRL) levels are low during non-breeding times and significantly increase during late incubation and early post-hatch chick care. Because of this pattern, PRL has been suggested to be involved in the initiation of parental care in birds, but rarely has this hypothesis been causally tested...
December 26, 2017: Hormones and Behavior
Christopher Harshaw, Joseph K Leffel, Jeffrey R Alberts
Oxytocin is a social and reproductive hormone that also plays critical roles in a range of homeostatic processes, including thermoregulation. Here, we examine the role of oxytocin (OT) as a mediator of brown adipose tissue (BAT) thermogenesis, cold-induced huddling, and positive thermotaxis in eight-day-old (PD8) OT 'knock out' (OTKO) mouse pups. We tested OTKO and wildtype (WT) pups in single- and mixed-genotype groups of six, exposing these to a period of ambient warmth (~35°C) followed by a period of cold (~21...
December 22, 2017: Hormones and Behavior
Jennifer Merritt, Matthew Davis, Cecilia Jalabert, Timothy Libecap, Donald Williams, Kiran Soma, Donna Maney
No abstract text is available yet for this article.
December 22, 2017: Hormones and Behavior
Grant M Ostrander, R Nathan Pipitone, Melanie L Shoup-Knox
Both men and women find female voices more attractive at higher fertility times in the menstrual cycle, suggesting the voice is a cue to fertility and/or hormonal status. Preference for fertile females' voices provides males with an obvious reproduction advantage, however the advantage for female listeners is less clear. One possibility is that attention to the fertility status of potential rivals may enable women to enhance their own reproductive strategies through intrasexual competition. If so, the response to having high fertility voices should include hormonal changes that promote competitive behavior...
December 22, 2017: Hormones and Behavior
R Domínguez-Ordóñez, M García-Juárez, F J Lima-Hernández, P Gómora-Arrati, E Domínguez-Salazar, J D Blaustein, A M Etgen, O González-Flores
The present study assessed the participation of membrane G-protein coupled estrogen receptor 1 (GPER-1) and gonadotropin releasing hormone 1 (GnRH-1) receptor in the display of lordosis induced by intracerebroventricular (icv) administration of G1, a GPER-1 agonist, and by unesterified 17β-estradiol (free E2). In addition, we assessed the participation of both estrogen and progestin receptors in the lordosis behavior induced by G1 in ovariectomized (OVX), E2-benzoate (EB)-primed rats. In Experiment 1, icv injection of G1 induced lordosis behavior at 120 and 240min...
December 18, 2017: Hormones and Behavior
Christina M Estrada, Valentina Ghisays, Elizabeth T Nguyen, Jody L Caldwell, Joshua Streicher, Matia B Solomon
Declining estradiol (E2), as occurs during menopause, increases risk for obesity and psychopathology (i.e., depression, anxiety). E2 modulates mood and energy homeostasis via binding to estrogen receptors (ER) in the brain. The often comorbid and bidirectional relationship between mood and metabolic disorders suggests shared hormonal and/or brain networks. The medial amygdala (MeA) is abundant in ERs and regulates mood, endocrine, and metabolic stress responses; therefore we tested the hypothesis that E2 in the MeA mitigates emotional and metabolic dysfunction in a rodent model of surgical menopause...
December 14, 2017: Hormones and Behavior
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