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Biological Psychiatry

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https://www.readbyqxmd.com/read/28359566/increased-plasma-beta-secretase-1-may-predict-conversion-to-alzheimer-s-disease-dementia-in-individuals-with-mild-cognitive-impairment
#1
Yong Shen, Haibo Wang, Qiying Sun, Hailan Yao, Andrew P Keegan, Mike Mullan, Jeffrey Wilson, Simone Lista, Thomas Leyhe, Christoph Laske, Dan Rujescu, Allan Levey, Anders Wallin, Kaj Blennow, Rena Li, Harald Hampel
BACKGROUND: Increased beta-secretase 1 (BACE1) activity has consistently been detected in brain tissue and cerebrospinal fluid of subjects with mild cognitive impairment (MCI) and probable Alzheimer's disease (AD) compared with control subjects. The collection of cerebrospinal fluid by lumbar puncture is invasive. We sought to identify the presence of plasma BACE1 activity and determine potential alterations in subjects with MCI with clinical follow-up examinations for 3 years using patients with diagnosed probable AD dementia compared with healthy control subjects...
March 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28410627/polyunsaturated-fatty-acids-in-perinatal-depression-a-systematic-review-and-meta-analysis
#2
Pao-Yen Lin, Cheng-Ho Chang, Mary Foong-Fong Chong, Helen Chen, Kuan-Pin Su
BACKGROUND: Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are promising antidepressant treatments for perinatal depression (PND) because of supporting evidence from clinical trials, the advantage in safety, and their anti-inflammatory and neuroplastic effects. Although several observational studies have shown n-3 PUFA deficits in women with PND, the results of individual PUFAs from different studies were inconsistent. METHODS: This systematic review and meta-analysis aims to compare the levels of PUFA indices, including eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, total n-3, total n-6, and the n-6/n-3 ratio between women with PND and healthy control subjects...
March 9, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28392081/increased-extra-axial-cerebrospinal-fluid-in-high-risk-infants-who-later-develop-autism
#3
Mark D Shen, Sun Hyung Kim, Robert C McKinstry, Hongbin Gu, Heather C Hazlett, Christine W Nordahl, Robert W Emerson, Dennis Shaw, Jed T Elison, Meghan R Swanson, Vladimir S Fonov, Guido Gerig, Stephen R Dager, Kelly N Botteron, Sarah Paterson, Robert T Schultz, Alan C Evans, Annette M Estes, Lonnie Zwaigenbaum, Martin A Styner, David G Amaral, Joseph Piven, J Piven, H C Hazlett, C Chappell, S Dager, A Estes, D Shaw, K Botteron, R McKinstry, J Constantino, J Pruett, R Schultz, L Zwaigenbaum, J Elison, A C Evans, D L Collins, G B Pike, V Fonov, P Kostopoulos, S Das, G Gerig, M Styner, H Gu
BACKGROUND: We previously reported that infants who developed autism spectrum disorder (ASD) had increased cerebrospinal fluid (CSF) in the subarachnoid space (i.e., extra-axial CSF) from 6 to 24 months of age. We attempted to confirm and extend this finding in a larger independent sample. METHODS: A longitudinal magnetic resonance imaging study of infants at risk for ASD was carried out on 343 infants, who underwent neuroimaging at 6, 12, and 24 months. Of these infants, 221 were at high risk for ASD because of an older sibling with ASD, and 122 were at low risk with no family history of ASD...
March 6, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28395871/a-circadian-genomic-signature-common-to-ketamine-and-sleep-deprivation-in-the-anterior-cingulate-cortex
#4
Ricardo Orozco-Solis, Emilie Montellier, Lorena Aguilar-Arnal, Shogo Sato, Marquis P Vawter, Blynn G Bunney, William E Bunney, Paolo Sassone-Corsi
BACKGROUND: Conventional antidepressants usually require several weeks to achieve a full clinical response in patients with major depressive disorder, an illness associated with dysregulated circadian rhythms and a high incidence of suicidality. Two rapid-acting antidepressant strategies, low-dose ketamine (KT) and sleep deprivation (SD) therapies, dramatically reduce depressive symptoms within 24 hours in a subset of major depressive disorder patients. However, it is unknown whether they exert their actions through shared regulatory mechanisms...
March 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28390647/brain-derived-neurotrophic-factor-in-the-mesolimbic-reward-circuitry-mediates-nociception-in-chronic-neuropathic-pain
#5
Hongxing Zhang, Yi-Ling Qian, Chen Li, Di Liu, Lei Wang, Xiao-Yi Wang, Mei-Jun Liu, He Liu, Song Zhang, Xiao-Yun Guo, Jun-Xia Yang, Hai-Lei Ding, Ja Wook Koo, Ezekiell Mouzon, Karl Deisseroth, Eric J Nestler, Venetia Zachariou, Ming-Hu Han, Jun-Li Cao
BACKGROUND: The mesolimbic reward system plays a critical role in modulating nociception; however, its underlying molecular, cellular, and neural circuitry mechanisms remain unknown. METHODS: Chronic constrictive injury (CCI) of the sciatic nerve was used to model neuropathic pain. Projection-specific in vitro recordings in mouse brain slices and in vivo recordings from anesthetized animals were used to measure firing of dopaminergic neurons in the ventral tegmental area (VTA)...
March 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28388995/brain-mechanisms-underlying-reactive-aggression-in-borderline-personality-disorder-sex-matters
#6
Sabine C Herpertz, Krisztina Nagy, Kai Ueltzhöffer, Ruth Schmitt, Falk Mancke, Christian Schmahl, Katja Bertsch
BACKGROUND: Aggression in borderline personality disorder (BPD) is thought to be mediated through emotion dysregulation via high trait anger. Until now, data comparing anger and aggression in female and male patients with BPD have been widely missing on the behavioral and particularly the brain levels. METHODS: Thirty-three female and 23 male patients with BPD and 30 healthy women and 26 healthy men participated in this functional magnetic resonance imaging study...
March 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28385279/-i-do-not-do-it-made-volition-in-insular-cortex-atrophy
#7
LETTER
Sayantanava Mitra, Seshadri Sekhar Chatterjee, Anjana Rao Kavoor, Vivek Chail
No abstract text is available yet for this article.
February 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28392082/neglect-as-a-violation-of-species-expectant-experience-neurodevelopmental-consequences
#8
REVIEW
Katie A McLaughlin, Margaret A Sheridan, Charles A Nelson
The human brain requires a wide variety of experiences and environmental inputs in order to develop normally. Children who are neglected by caregivers or raised in institutional environments are deprived of numerous types of species-expectant environmental experiences. In this review, we articulate a model of how the absence of cognitive stimulation and sensory, motor, linguistic, and social experiences common among children raised in deprived early environments constrains early forms of learning, producing long-term deficits in complex cognitive function and associative learning...
February 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28242013/targeting-the-microbiota-gut-brain-axis-prebiotics-have-anxiolytic-and-antidepressant-like-effects-and-reverse-the-impact-of-chronic-stress-in-mice
#9
Aurelijus Burokas, Silvia Arboleya, Rachel D Moloney, Veronica L Peterson, Kiera Murphy, Gerard Clarke, Catherine Stanton, Timothy G Dinan, John F Cryan
BACKGROUND: The realization that the microbiota-gut-brain axis plays a critical role in health and disease, including neuropsychiatric disorders, is rapidly advancing. Nurturing a beneficial gut microbiome with prebiotics, such as fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS), is an appealing but underinvestigated microbiota manipulation. Here we tested whether chronic prebiotic treatment modifies behavior across domains relevant to anxiety, depression, cognition, stress response, and social behavior...
February 24, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28359565/deficits-in-neurite-density-underlie-white-matter-structure-abnormalities-in-first-episode-psychosis
#10
Charlotte L Rae, Geoff Davies, Sarah N Garfinkel, Matt C Gabel, Nicholas G Dowell, Mara Cercignani, Anil K Seth, Kathryn E Greenwood, Nick Medford, Hugo D Critchley
BACKGROUND: Structural abnormalities across multiple white matter tracts are recognized in people with early psychosis, consistent with dysconnectivity as a neuropathological account of symptom expression. We applied advanced neuroimaging techniques to characterize microstructural white matter abnormalities for a deeper understanding of the developmental etiology of psychosis. METHODS: Thirty-five first-episode psychosis patients, and 19 healthy controls, participated in a quantitative neuroimaging study using neurite orientation dispersion and density imaging, a multishell diffusion-weighted magnetic resonance imaging technique that distinguishes white matter fiber arrangement and geometry from changes in neurite density...
February 17, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28359564/cingulate-overexpression-of-mitogen-activated-protein-kinase-phosphatase-1-as-a-key-factor-for-depression
#11
Florent Barthas, Muris Humo, Ralf Gilsbach, Elisabeth Waltisperger, Meltem Karatas, Samuel Leman, Lutz Hein, Catherine Belzung, Anne-Laurence Boutillier, Michel Barrot, Ipek Yalcin
BACKGROUND: Depression is frequently associated with chronic pain or chronic stress. Among cortical areas, the anterior cingulate cortex (ACC, areas 24a and 24b) appears to be important for mood disorders and constitutes a neuroanatomical substrate for investigating the underlying molecular mechanisms. The current work aimed at identifying ACC molecular factors subserving depression. METHODS: Anxiodepressive-like behaviors in C57BL/6J male mice were induced by neuropathic pain, unpredictable chronic mild stress, and optogenetic ACC stimulation and were evaluated using novelty suppressed feeding, splash, and forced swim tests...
February 14, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28364943/amygdala-lesions-reduce-anxiety-like-behavior-in-a-human-benzodiazepine-sensitive-approach-avoidance-conflict-test
#12
Christoph W Korn, Johanna Vunder, Júlia Miró, Lluís Fuentemilla, Rene Hurlemann, Dominik R Bach
BACKGROUND: Rodent approach-avoidance conflict tests are common preclinical models of human anxiety disorder. Their translational validity mainly rests on the observation that anxiolytic drugs reduce rodent anxiety-like behavior. Here, we capitalized on a recently developed approach-avoidance conflict computer game to investigate the impact of benzodiazepines and of amygdala lesions on putative human anxiety-like behavior. In successive epochs of this game, participants collect monetary tokens on a spatial grid while under threat of virtual predation...
February 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28347488/targeted-interneuron-depletion-in-the-dorsal-striatum-produces-autism-like-behavioral-abnormalities-in-male-but-not-female-mice
#13
Maximiliano Rapanelli, Luciana Romina Frick, Meiyu Xu, Stephanie Mary Groman, Kantiya Jindachomthong, Nobuaki Tamamaki, Chiyoko Tanahira, Jane Rebecca Taylor, Christopher Pittenger
BACKGROUND: Interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (FSIs) and the large cholinergic interneurons (CINs), are affected in patients with TS and in preclinical models of both ASD and TS. METHODS: To test the causal importance of these neuronal abnormalities, we recapitulated them in vivo in developmentally normal mice using a combination transgenic-viral strategy for targeted toxin-mediated ablation...
February 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28343697/modeling-avoidance-in-mood-and-anxiety-disorders-using-reinforcement-learning
#14
Anahit Mkrtchian, Jessica Aylward, Peter Dayan, Jonathan P Roiser, Oliver J Robinson
BACKGROUND: Serious and debilitating symptoms of anxiety are the most common mental health problem worldwide, accounting for around 5% of all adult years lived with disability in the developed world. Avoidance behavior-avoiding social situations for fear of embarrassment, for instance-is a core feature of such anxiety. However, as for many other psychiatric symptoms the biological mechanisms underlying avoidance remain unclear. METHODS: Reinforcement learning models provide formal and testable characterizations of the mechanisms of decision making; here, we examine avoidance in these terms...
February 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28267988/left-right-asymmetry-of-maturation-rates-in-human-embryonic-neural-development
#15
Carolien G F de Kovel, Steven Lisgo, Guy Karlebach, Jia Ju, Gang Cheng, Simon E Fisher, Clyde Francks
BACKGROUND: Left-right asymmetry is a fundamental organizing feature of the human brain, and neuropsychiatric disorders such as schizophrenia sometimes involve alterations of brain asymmetry. As early as 8 weeks postconception, the majority of human fetuses move their right arms more than their left arms, but because nerve fiber tracts are still descending from the forebrain at this stage, spinal-muscular asymmetries are likely to play an important developmental role. METHODS: We used RNA sequencing to measure gene expression levels in the left and right spinal cords, and the left and right hindbrains, of 18 postmortem human embryos aged 4 to 8 weeks postconception...
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28318491/late-life-depression-hippocampal-volumes-and-hypothalamic-pituitary-adrenal-axis-regulation-a-systematic-review-and-meta-analysis
#16
Mirjam I Geerlings, Lotte Gerritsen
BACKGROUND: We systematically reviewed and meta-analyzed the association of late-life depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of cortisol levels with HCV, including subgroup analyses of depression characteristics and methodological aspects. METHODS: We searched PubMed and Embase for original studies that examined the cross-sectional relationship between LLD and HCV or TBV, and 46 studies fulfilled the inclusion criteria. Standardized mean differences (Hedges' g) between LLD and control subjects were calculated from crude or adjusted brain volumes using random effects...
January 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28314439/reversing-the-atypical-valuation-of-drug-and-nondrug-rewards-in-smokers-using-multimodal-neuroimaging
#17
Travis E Baker, Paul Lesperance, Alan Tucholka, Stephane Potvin, Kevin Larcher, Yu Zhang, Didier Jutras-Aswad, Patricia Conrod
BACKGROUND: Chronic substance use can disrupt the reward function of the anterior cingulate cortex (ACC), biasing the ACC to favor goal-directed behaviors that converge on drug use. Here we used multimodal neuroimaging methods to ask whether modulating reward-related signaling in the ACC can reverse the atypical valuation of nondrug and drug rewards in abstinent smokers. METHODS: We first recorded functional magnetic resonance imaging data from 20 moderately dependent cigarette smokers (mean age = 25 years; no history of neuropsychiatric disorders), following an overnight period of abstinence, to identify regions of the left dorsal lateral prefrontal cortex associated with the anticipation of drug-related rewards (cigarette puff)...
January 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28256214/opposing-effects-on-nav1-2-function-underlie-differences-between-scn2a-variants-observed-in-individuals-with-autism-spectrum-disorder-or-infantile-seizures
#18
Roy Ben-Shalom, Caroline M Keeshen, Kiara N Berrios, Joon Y An, Stephan J Sanders, Kevin J Bender
BACKGROUND: Variants in the SCN2A gene that disrupt the encoded neuronal sodium channel NaV1.2 are important risk factors for autism spectrum disorder (ASD), developmental delay, and infantile seizures. Variants observed in infantile seizures are predominantly missense, leading to a gain of function and increased neuronal excitability. How variants associated with ASD affect NaV1.2 function and neuronal excitability are unclear. METHODS: We examined the properties of 11 ASD-associated SCN2A variants in heterologous expression systems using whole-cell voltage-clamp electrophysiology and immunohistochemistry...
January 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28391806/role-of-cyfip2-in-binge-eating
#19
Jian Feng
No abstract text is available yet for this article.
May 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28391805/eat-to-live-or-live-to-eat-the-neurobiology-of-appetite-regulation
#20
Kathryn R Kinasz, David A Ross, Joseph J Cooper
No abstract text is available yet for this article.
May 1, 2017: Biological Psychiatry
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