journal
MENU ▼
Read by QxMD icon Read
search

Biological Psychiatry

journal
https://www.readbyqxmd.com/read/28063469/how-can-global-alteration-of-excitation-inhibition-balance-lead-to-the-local-dysfunctions-that-underlie-schizophrenia
#1
Alan Anticevic, John Lisman
No abstract text is available yet for this article.
January 4, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28087128/intranasal-oxytocin-to-prevent-posttraumatic-stress-disorder-symptoms-a-randomized-controlled-trial-in-emergency-department-patients
#2
Mirjam van Zuiden, Jessie L Frijling, Laura Nawijn, Saskia B J Koch, J Carel Goslings, Jan S Luitse, Tessa H Biesheuvel, Adriaan Honig, Dick J Veltman, Miranda Olff
BACKGROUND: There are currently few preventive interventions available for posttraumatic stress disorder (PTSD). Intranasal oxytocin administration early after trauma may prevent PTSD, because oxytocin administration was previously found to beneficially impact PTSD vulnerability factors, including neural fear responsiveness, peripheral stress reactivity, and socioemotional functioning. Therefore, we investigated the effects of intranasal oxytocin administration early after trauma on subsequent clinician-rated PTSD symptoms...
December 8, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28073491/gray-matter-neuritic-microstructure-deficits-in-schizophrenia-and-bipolar-disorder
#3
Arash Nazeri, Benoit H Mulsant, Tarek K Rajji, Melissa L Levesque, Jon Pipitone, Laura Stefanik, Saba Shahab, Tina Roostaei, Anne L Wheeler, Sofia Chavez, Aristotle N Voineskos
BACKGROUND: Postmortem studies have demonstrated considerable dendritic pathologies among persons with schizophrenia and to some extent among those with bipolar I disorder. Modeling gray matter (GM) microstructural properties is now possible with a recently proposed diffusion-weighted magnetic resonance imaging modeling technique: neurite orientation dispersion and density imaging. This technique may bridge the gap between neuroimaging and histopathological findings. METHODS: We performed an extended series of multishell diffusion-weighted imaging and other structural imaging series using 3T magnetic resonance imaging...
December 8, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28049566/an-analysis-of-two-genome-wide-association-meta-analyses-identifies-a-new-locus-for-broad-depression-phenotype
#4
Nese Direk, Stephanie Williams, Jennifer A Smith, Stephan Ripke, Tracy Air, Azmeraw T Amare, Najaf Amin, Bernhard T Baune, David A Bennett, Douglas H R Blackwood, Dorret Boomsma, Gerome Breen, Henriette N Buttenschøn, Enda M Byrne, Anders D Børglum, Enrique Castelao, Sven Cichon, Toni-Kim Clarke, Marilyn C Cornelis, Udo Dannlowski, Philip L De Jager, Ayse Demirkan, Enrico Domenici, Cornelia M van Duijn, Erin C Dunn, Johan G Eriksson, Tonu Esko, Jessica D Faul, Luigi Ferrucci, Myriam Fornage, Eco de Geus, Michael Gill, Scott D Gordon, Hans Jörgen Grabe, Gerard van Grootheest, Steven P Hamilton, Catharina A Hartman, Andrew C Heath, Karin Hek, Albert Hofman, Georg Homuth, Carsten Horn, Jouke Jan Hottenga, Sharon L R Kardia, Stefan Kloiber, Karestan Koenen, Zoltán Kutalik, Karl-Heinz Ladwig, Jari Lahti, Douglas F Levinson, Cathryn M Lewis, Glyn Lewis, Qingqin S Li, David J Llewellyn, Susanne Lucae, Kathryn L Lunetta, Donald J MacIntyre, Pamela Madden, Nicholas G Martin, Andrew M McIntosh, Andres Metspalu, Yuri Milaneschi, Grant W Montgomery, Ole Mors, Thomas H Mosley, Joanne M Murabito, Bertram Müller-Myhsok, Markus M Nöthen, Dale R Nyholt, Michael C O'Donovan, Brenda W Penninx, Michele L Pergadia, Roy Perlis, James B Potash, Martin Preisig, Shaun M Purcell, Jorge A Quiroz, Katri Räikkönen, John P Rice, Marcella Rietschel, Margarita Rivera, Thomas G Schulze, Jianxin Shi, Stanley Shyn, Grant C Sinnamon, Johannes H Smit, Jordan W Smoller, Harold Snieder, Toshiko Tanaka, Katherine E Tansey, Alexander Teumer, Rudolf Uher, Daniel Umbricht, Sandra Van der Auwera, Erin B Ware, David R Weir, Myrna M Weissman, Gonneke Willemsen, Jingyun Yang, Wei Zhao, Henning Tiemeier, Patrick F Sullivan
BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder. METHODS: We analyzed two prior studies of 70,017 participants of European ancestry from general and clinical populations in the discovery stage...
December 8, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28017300/acute-frequency-dependent-hypomania-induced-by-ventral-subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease-a-case-report
#5
LETTER
Katherine Wilson Scangos, Kiarash Shahlaie
No abstract text is available yet for this article.
December 7, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28010876/central-ghrelin-resistance-permits-the-overconsolidation-of-fear-memory
#6
Elia S Harmatz, Lauren Stone, Seh Hong Lim, Graham Lee, Anna McGrath, Barbara Gisabella, Xiaoyu Peng, Eliza Kosoy, Junmei Yao, Elizabeth Liu, Nuno J Machado, Veronica S Weiner, Warren Slocum, Rodrigo A Cunha, Ki A Goosens
BACKGROUND: There are many contradictory findings about the role of the hormone ghrelin in aversive processing, with studies suggesting that ghrelin signaling can both inhibit and enhance aversion. Here, we characterize and reconcile the paradoxical role of ghrelin in the acquisition of fearful memories. METHODS: We used enzyme-linked immunosorbent assay to measure endogenous acyl-ghrelin and corticosterone at time points surrounding auditory fear learning. We used pharmacological (systemic and intra-amygdala) manipulations of ghrelin signaling and examined several aversive and appetitive behaviors...
November 29, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27876357/building-a-new-field-of-computational-psychiatry
#7
Michael Moutoussis, Eran Eldar, Raymond J Dolan
No abstract text is available yet for this article.
November 19, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27836100/clinical-advances-from-a-computational-approach-to-anxiety
#8
Daniel S Pine
No abstract text is available yet for this article.
November 7, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27939396/a-role-for-peroxisome-proliferator-activated-receptor-gamma-coactivator-1%C3%AE-in-nucleus-accumbens-neuron-subtypes-in-cocaine-action
#9
Ramesh Chandra, Michel Engeln, T Chase Francis, Prasad Konkalmatt, Dipal Patel, Mary Kay Lobo
BACKGROUND: Molecules critically involved in cocaine behavioral plasticity are known to regulate and interact with peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). In addition, the PGC-1α promoter has binding sites for early growth response 3 (Egr3), which plays a dynamic role in cocaine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 (D1-MSN) versus D2 (D2-MSN). However, the role of PGC-1α in NAc in cocaine action is unknown...
October 28, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27914629/cytoplasmic-fmr1-interacting-protein-2-is-a-major-genetic-factor-underlying-binge-eating
#10
Stacey L Kirkpatrick, Lisa R Goldberg, Neema Yazdani, R Keith Babbs, Jiayi Wu, Eric R Reed, David F Jenkins, Amanda F Bolgioni, Kelsey I Landaverde, Kimberly P Luttik, Karen S Mitchell, Vivek Kumar, W Evan Johnson, Megan K Mulligan, Pietro Cottone, Camron D Bryant
BACKGROUND: Eating disorders are lethal and heritable; however, the underlying genetic factors are unknown. Binge eating is a highly heritable trait associated with eating disorders that is comorbid with mood and substance use disorders. Therefore, understanding its genetic basis will inform therapeutic development that could improve several comorbid neuropsychiatric conditions. METHODS: We assessed binge eating in closely related C57BL/6 mouse substrains and in an F2 cross to identify quantitative trait loci associated with binge eating...
October 25, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27931744/learning-from-one-s-mistakes-a-dual-role-for-the-rostromedial-tegmental-nucleus-in-the-encoding-and-expression-of-punished-reward-seeking
#11
Peter J Vento, Nathan W Burnham, Courtney S Rowley, Thomas C Jhou
BACKGROUND: Psychiatric disorders such as addiction and mania are marked by persistent reward seeking despite highly negative or aversive outcomes, but the neural mechanisms underlying this aberrant decision making are unknown. The recently identified rostromedial tegmental nucleus (RMTg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections to midbrain dopamine neurons, leading to the hypothesis that the RMTg provides a brake to reward signaling in response to aversive costs...
October 21, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27832841/new-concepts-in-dopamine-d2-receptor-biased-signaling-and-implications-for-schizophrenia-therapy
#12
REVIEW
Nikhil M Urs, Sean M Peterson, Marc G Caron
The dopamine D2 receptor (D2R) is a G protein-coupled receptor that is a common target for antipsychotic drugs. Antagonism of D2R signaling in the striatum is thought to be the primary mode of action of antipsychotic drugs in alleviating psychotic symptoms. However, antipsychotic drugs are not clinically effective at reversing cortical-related symptoms, such as cognitive deficits in schizophrenia. While the exact mechanistic underpinnings of these cognitive deficits are largely unknown, deficits in cortical dopamine function likely play a contributing role...
October 19, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28024708/fearing-the-mother-s-virus-the-lasting-consequences-of-prenatal-immune-activation-on-the-epigenome-and-brain-function
#13
Marija Kundakovic
No abstract text is available yet for this article.
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28024707/oxytocin-and-the-social-brain
#14
Sarah K Fineberg, David A Ross
No abstract text is available yet for this article.
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28024706/neurochemicals-drawing-the-line-between-love-and-hate
#15
Nicholas J Hobbs, Ashlyn Swift-Gallant, Cynthia L Jordan, S Marc Breedlove
No abstract text is available yet for this article.
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28024705/common-variation-in-the-gtf2i-gene-a-promising-neurogenetic-mechanism-for-affiliative-drive-and-social-anxiety
#16
Janina I Schweiger, Andreas Meyer-Lindenberg
No abstract text is available yet for this article.
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28024704/protocadherins-and-the-social-brain
#17
Nien-Pei Tsai, Kimberly M Huber
No abstract text is available yet for this article.
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27769567/genome-wide-dna-methylation-changes-in-a-mouse-model-of-infection-mediated-neurodevelopmental-disorders
#18
Juliet Richetto, Renaud Massart, Ulrike Weber-Stadlbauer, Moshe Szyf, Marco A Riva, Urs Meyer
BACKGROUND: Prenatal exposure to infectious or inflammatory insults increases the risk of neurodevelopmental disorders. Using a well-established mouse model of prenatal viral-like immune activation, we examined whether this pathological association involves genome-wide DNA methylation differences at single nucleotide resolution. METHODS: Prenatal immune activation was induced by maternal treatment with the viral mimetic polyriboinosinic-polyribocytidylic acid in middle or late gestation...
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27639500/impaired-communication-between-the-motor-and-somatosensory-homunculus-is-associated-with-poor-manual-dexterity-in-autism-spectrum-disorder
#19
Abigail Thompson, Declan Murphy, Flavio Dell'Acqua, Christine Ecker, Grainne McAlonan, Henrietta Howells, Simon Baron-Cohen, Meng-Chuan Lai, Michael V Lombardo
BACKGROUND: Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these connections has not been directly investigated in humans. This study aimed to investigate, for the first time, the role of the S1-M1 connections in healthy subjects in vivo and whether microstructural alterations are associated with motor impairment in ASD...
February 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27587266/severe-intellectual-disability-and-enhanced-gamma-aminobutyric-acidergic-synaptogenesis-in-a-novel-model-of-rare-rasopathies
#20
Alessandro Papale, Raffaele d'Isa, Elisabetta Menna, Milica Cerovic, Nicola Solari, Neil Hardingham, Marco Cambiaghi, Marco Cursi, Mariano Barbacid, Letizia Leocani, Stefania Fasano, Michela Matteoli, Riccardo Brambilla
BACKGROUND: Dysregulation of Ras-extracellular signal-related kinase (ERK) signaling gives rise to RASopathies, a class of neurodevelopmental syndromes associated with intellectual disability. Recently, much attention has been directed at models bearing mild forms of RASopathies whose behavioral impairments can be attenuated by inhibiting the Ras-ERK cascade in the adult. Little is known about the brain mechanisms in severe forms of these disorders. METHODS: We performed an extensive characterization of a new brain-specific model of severe forms of RASopathies, the KRAS(12V) mutant mouse...
February 1, 2017: Biological Psychiatry
journal
journal
22234
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"