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Biological Psychiatry

Alice Poisson, Nicolas Chatron, Audrey Labalme, Marianne Till, Emmanuel Broussolle, Damien Sanlaville, Caroline Demily, Gaetan Lesca
No abstract text is available yet for this article.
August 24, 2018: Biological Psychiatry
Ajay Manhapra, Elizabeth Ralevski, Ismene L Petrakis
No abstract text is available yet for this article.
August 24, 2018: Biological Psychiatry
Colleen A Hanlon, Noah S Philip, Rebecca B Price, Warren K Bickel, Jonathan Downar
No abstract text is available yet for this article.
August 17, 2018: Biological Psychiatry
Yan Jouroukhin, Xiaolei Zhu, Alexey V Shevelkin, Yuto Hasegawa, Bagrat Abazyan, Atsushi Saito, Jonathan Pevsner, Atsushi Kamiya, Mikhail V Pletnikov
BACKGROUND: Although several studies have linked adolescent cannabis use to long-term cognitive dysfunction, there are negative reports as well. The fact that not all users develop cognitive impairment suggests a genetic vulnerability to adverse effects of cannabis, which are attributed to action of Δ9-tetrahydrocannabinol (Δ9 -THC), a cannabis constituent and partial agonist of brain cannabinoid receptor 1. As both neurons and glial cells express cannabinoid receptor 1, genetic vulnerability could influence Δ9 -THC-induced signaling in a cell type-specific manner...
August 16, 2018: Biological Psychiatry
Koen Bolhuis, Ryan L Muetzel, Argyris Stringaris, James J Hudziak, Vincent W V Jaddoe, Manon H J Hillegers, Tonya White, Steven A Kushner, Henning Tiemeier
BACKGROUND: Studies of white matter connectivity in children with disruptive behavior have yielded inconsistent results, possibly owing to the trait's heterogeneity, which comprises diverse symptoms like physical aggression, irritability, and delinquency. This study examined associations of global and specific white matter connectivity with childhood disruptive behavior problems, while accounting for their complex multidimensionality. METHODS: In a large cross-sectional population-based study of 10-year-old preadolescents (n = 2567), we assessed four previously described empirically derived dimensions of disruptive behavior problems using the Child Behavior Checklist: physical aggression, irritability, disobedient behavior, and delinquent behavior...
August 14, 2018: Biological Psychiatry
Eleanor J Cole, Peter G Enticott, Lindsay M Oberman, M Frampton Gwynette, Manuel F Casanova, Scott L J Jackson, Ali Jannati, James C McPartland, Adam J Naples, Nicolaas A J Puts
No abstract text is available yet for this article.
August 10, 2018: Biological Psychiatry
Joseph R Whittaker, Sonya F Foley, Edward Ackling, Kevin Murphy, Xavier Caseras
BACKGROUND: Alterations in functional connectivity between the nucleus accumbens (NAcc) and frontal cortices have been previously associated with the presence of psychiatric syndromes, including bipolar disorder (BD). Whether these alterations are a consequence or a risk factor for mental disorders remains unresolved. METHODS: This study included 35 patients with BD, 30 nonaffected siblings of patients with BD, and 23 healthy control subjects to probe functional connectivity at rest between NAcc and the rest of the brain in a cross-sectional design...
August 7, 2018: Biological Psychiatry
Morgan H James, Colin M Stopper, Benjamin A Zimmer, Nikki E Koll, Hannah E Bowrey, Gary Aston-Jones
BACKGROUND: The orexin (hypocretin) system is important for reward-driven motivation but has not been implicated in the expression of a multiphenotype addicted state. METHODS: Rats were assessed for economic demand for cocaine before and after 14 days of short access, long access, or intermittent access (IntA) to cocaine. Rats were also assessed for a number of other DSM-5-relevant addiction criteria following differential access conditions. Orexin system function was assessed by quantification of numbers and activity of orexin cells, pharmacological blockade of the orexin-1 receptor, and subregion-specific knockdown of orexin cell populations...
August 7, 2018: Biological Psychiatry
Kaustubh Supekar, Weidong Cai, Rajeev Krishnadas, Lena Palaniyappan, Vinod Menon
BACKGROUND: Schizophrenia is a highly disabling psychiatric disorder characterized by a range of positive "psychosis" symptoms. However, the neurobiology of psychosis and associated systems-level disruptions in the brain remain poorly understood. Here, we test an aberrant saliency model of psychosis, which posits that dysregulated dynamic cross-network interactions among the salience network (SN), central executive network, and default mode network contribute to positive symptoms in patients with schizophrenia...
August 1, 2018: Biological Psychiatry
Lilah Toker, Burak Ogan Mancarci, Shreejoy Tripathy, Paul Pavlidis
BACKGROUND: High-throughput expression analyses of postmortem brain tissue have been widely used to study bipolar disorder and schizophrenia. However, despite the extensive efforts, no consensus has emerged as to the functional interpretation of the findings. We hypothesized that incorporating information on cell type-specific expression would provide new insights. METHODS: We reanalyzed 15 publicly available bulk tissue expression datasets on schizophrenia and bipolar disorder, representing various brain regions from eight different cohorts of subjects (unique subjects: 332 control, 129 bipolar disorder, 341 schizophrenia)...
July 21, 2018: Biological Psychiatry
Craig T Werner, Rathipriya Viswanathan, Jennifer A Martin, Pedro H Gobira, Swarup Mitra, Shruthi A Thomas, Zi-Jun Wang, Jian-Feng Liu, Andrew F Stewart, Rachael L Neve, Jun-Xu Li, Amy M Gancarz, David M Dietz
BACKGROUND: Substance use disorder is a neurobiological disease characterized by episodes of relapse despite periods of withdrawal. It is thought that neuroadaptations in discrete brain areas of the reward pathway, including the nucleus accumbens, underlie these aberrant behaviors. The ubiquitin-proteasome system degrades proteins and has been shown to be involved in cocaine-induced plasticity, but the role of E3 ubiquitin ligases, which conjugate ubiquitin to substrates, is unknown. Here, we examined E3 ubiquitin-protein ligase SMURF1 (SMURF1) in neuroadaptations and relapse behavior during withdrawal following cocaine self-administration...
July 21, 2018: Biological Psychiatry
Jussi Hirvonen, Paolo Zanotti-Fregonara, David A Gorelick, Chul Hyoung Lyoo, Denise Rallis-Frutos, Cheryl Morse, Sami S Zoghbi, Victor W Pike, Nora D Volkow, Marilyn A Huestis, Robert B Innis
BACKGROUND: Previous studies showed reduction of brain cannabinoid CB1 receptors in adults with cannabis and alcohol use disorders. Preclinical data suggest that these receptors also contribute to nicotine reward and dependence. Tobacco smoking may confound clinical studies of psychiatric disorders because many patients with such disorders smoke tobacco. Whether human subjects who smoke tobacco but are otherwise healthy have altered CB1 receptor binding in brain is unknown. METHODS: We measured CB1 receptors in brains of 18 healthy men who smoke tobacco (frequent chronic cigarette smokers), and 28 healthy men who do not smoke tobacco, using positron emission tomography and [18 F]FMPEP-d2 , a radioligand for CB1 receptors...
July 21, 2018: Biological Psychiatry
Annika Forsingdal, Trine Nygaard Jørgensen, Line Olsen, Thomas Werge, Michael Didriksen, Jacob Nielsen
The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal models. Together with absence of a clear underlying pathology and understanding of what causes schizophrenia, this has hindered development of informative animal models. However, recent large-scale genomic studies have identified copy number variants (CNVs) that confer high risk of schizophrenia and have opened a new avenue for generation of relevant animal models. Eight recurrent CNVs have reproducibly been shown to increase the risk of schizophrenia by severalfold: 22q11...
July 12, 2018: Biological Psychiatry
Sonja Stojanovski, Daniel Felsky, Joseph D Viviano, Saba Shahab, Rutwik Bangali, Christie L Burton, Gabriel A Devenyi, Lauren J O'Donnell, Peter Szatmari, M Mallar Chakravarty, Stephanie Ameis, Russell Schachar, Aristotle N Voineskos, Anne L Wheeler
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a major sequela of traumatic brain injury (TBI) in youths. The objective of this study was to examine whether ADHD symptoms are differentially associated with genetic risk and brain structure in youths with and without a history of TBI. METHODS: Medical history, ADHD symptoms, genetic data, and neuroimaging data were obtained from a community sample of youths. ADHD symptom severity was compared between those with and without TBI (TBI n = 418, no TBI n = 3193)...
July 12, 2018: Biological Psychiatry
Sameer Jauhar, Mattia Veronese, Matthew M Nour, Maria Rogdaki, Pamela Hathway, Sridhar Natesan, Federico Turkheimer, James Stone, Alice Egerton, Philip McGuire, Shitij Kapur, Oliver D Howes
BACKGROUND: Elevated striatal dopamine synthesis capacity has been implicated in the etiology and antipsychotic response in psychotic illness. The effects of antipsychotic medication on dopamine synthesis capacity are poorly understood, and no prospective studies have examined this question in a solely first-episode psychosis sample. Furthermore, it is unknown whether antipsychotic efficacy is linked to reductions in dopamine synthesis capacity. We conducted a prospective [18 F]-dihydroxyphenyl-L-alanine positron emission tomography study in antipsychotic naïve/free people with first-episode psychosis commencing antipsychotic treatment...
July 11, 2018: Biological Psychiatry
Alice M Graham, Jerod M Rasmussen, Sonja Entringer, Elizabeth Ben Ward, Marc D Rudolph, John H Gilmore, Martin Styner, Pathik D Wadhwa, Damien A Fair, Claudia Buss
BACKGROUND: Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and psychiatric disorders. Research examining maternal cortisol concentrations across pregnancy and offspring neurodevelopment proximal to birth is needed to advance understanding in this area and lead to insight into the etiology of these disorders. METHODS: Participants were 70 adult women recruited during early pregnancy and their infants born after 34 weeks gestation...
July 7, 2018: Biological Psychiatry
Jun-Yu Zhang, Tao-Hui Liu, Ye He, Han-Qing Pan, Wen-Hua Zhang, Xiao-Ping Yin, Xiao-Li Tian, Bao-Ming Li, Xiao-Dong Wang, Andrew Holmes, Ti-Fei Yuan, Bing-Xing Pan
BACKGROUND: Chronic stress exposure increases the risk of developing various neuropsychiatric illnesses. The behavioral sequelae of stress correlate with dendritic hypertrophy and glutamate-related synaptic remodeling at basolateral amygdala projection neurons (BLA PNs). Yet, though BLA PNs are functionally heterogeneous with diverse corticolimbic targets, it remains unclear whether stress differentially impacts specific output circuits. METHODS: Confocal imaging was used to reconstruct the morphology of mouse BLA PNs with the aid of retrograde tracing and biocytin staining...
July 5, 2018: Biological Psychiatry
Karen L Lindsay, Claudia Buss, Pathik D Wadhwa, Sonja Entringer
Growing evidence supports an important role for the intrauterine environment in shaping fetal development and subsequent child health and disease risk. The fetal brain is particularly plastic, whereby even subtle changes in structure and function produced by in utero conditions can have long-term implications. Based on the consideration that conditions related to energy substrate and likelihood of survival to reproductive age are particularly salient drivers of fetal programming, maternal nutrition and stress represent the most commonly, but independently, studied factors in this context...
July 4, 2018: Biological Psychiatry
Edward H Patzelt, Wouter Kool, Alexander J Millner, Samuel J Gershman
BACKGROUND: Human decision making exhibits a mixture of model-based and model-free control. Recent evidence indicates that arbitration between these two modes of control ("metacontrol") is based on their relative costs and benefits. While model-based control may increase accuracy, it requires greater computational resources, so people invoke model-based control only when potential rewards exceed those of model-free control. We used a sequential decision task, while concurrently manipulating performance incentives, to ask if symptoms and traits of psychopathology decrease or increase model-based control in response to incentives...
July 2, 2018: Biological Psychiatry
Alexis E Cullen, Scarlett Holmes, Thomas A Pollak, Graham Blackman, Dan W Joyce, Matthew J Kempton, Robin M Murray, Philip McGuire, Valeria Mondelli
BACKGROUND: A relationship between non-neurological autoimmune (NNAI) disorders and psychosis has been widely reported but not yet subjected to meta-analysis. We conducted the first meta-analysis examining the association between NNAI disorders and psychosis and investigated the effect of 1) temporality (as determined by study design), 2) psychiatric diagnosis, and 3) specific autoimmune disorders. METHODS: Major databases were searched for articles published until April 2018; 31 studies, comprising data for >25 million individuals, were eligible...
June 28, 2018: Biological Psychiatry
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