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Biological Psychiatry

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https://www.readbyqxmd.com/read/28918940/biological-psychiatry-a-new-approach-to-reviews
#1
EDITORIAL
John H Krystal
No abstract text is available yet for this article.
September 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28917609/contribution-to-mentorship-and-promoting-women-in-science
#2
Cindy L Ehlers, Michele L Pergadia, Astrid K Stoker, Styliani Vlachou
No abstract text is available yet for this article.
September 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28935211/sustained-molecular-pathology-across-episodes-and-remission-in-major-depressive-disorder
#3
Enzo Scifo, Mohan Pabba, Fenika Kapadia, Tianzhou Ma, David A Lewis, George C Tseng, Etienne Sibille
BACKGROUND: Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from life-long recurring episodes of increasing severity, reduced therapeutic response, and shorter remission periods, suggesting the presence of a persistent and potentially progressive pathology. METHODS: Subgenual anterior cingulate cortex postmortem samples from four MDD cohorts (single episode, n = 20; single episode in remission, n = 15; recurrent episode, n = 20; and recurrent episode in remission, n = 15), and one control cohort (n = 20) were analyzed by mass spectrometry-based proteomics (n = 3630 proteins) combined with statistical analyses...
August 18, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28939116/elevated-translocator-protein-in-anterior-cingulate-in-major-depression-and-a-role-for-inflammation-in-suicidal-thinking-a-positron-emission-tomography-study
#4
Sophie E Holmes, Rainer Hinz, Silke Conen, Catherine J Gregory, Julian C Matthews, Jose M Anton-Rodriguez, Alexander Gerhard, Peter S Talbot
BACKGROUND: Major depressive disorder is associated with raised peripheral inflammatory markers. Mounting evidence also suggests that inflammation is involved in suicidal behavior. However, the involvement of inflammation in the brains of individuals with depression, and its association with suicidal ideation, needs further clarification. Translocator protein (TSPO), which is upregulated in activated glia (predominantly microglia), can be measured as an indication of neuroinflammation in vivo using positron emission tomography and TSPO-specific radioligands...
August 12, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28916387/the-ptsd-psychopharmacology-working-group-two%C3%A2-suggestions
#5
LETTER
Ripu D Jindal
No abstract text is available yet for this article.
August 12, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28918941/modulation-of-%C3%AE-and-%C3%AE-secretases-as-early-prevention-against-alzheimer-s-disease
#6
REVIEW
Iryna Voytyuk, Bart De Strooper, Lucía Chávez-Gutiérrez
The genetic evidence implicating amyloid-β in the initial stage of Alzheimer's disease is unequivocal. However, the long biochemical and cellular prodromal phases of the disease suggest that dementia is the result of a series of molecular and cellular cascades whose nature and connections remain unknown. Therefore, it is unlikely that treatments directed at amyloid-β will have major clinical effects in the later stages of the disease. We discuss the two major candidate therapeutic targets to lower amyloid-β in a preventive mode, i...
August 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28886760/network-mechanisms-of-clinical-response-to%C3%A2-transcranial-magnetic-stimulation-in-posttraumatic-stress-disorder-and-major-depressive-disorder
#7
Noah S Philip, Jennifer Barredo, Mascha van 't Wout-Frank, Audrey R Tyrka, Lawrence H Price, Linda L Carpenter
BACKGROUND: Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study to evaluate TMS-associated changes in connectivity in patients with comorbid posttraumatic stress disorder and MDD. METHODS: Resting-state functional connectivity magnetic resonance imaging was acquired before and after TMS therapy in 33 adult outpatients in a prospective open trial...
August 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28941549/the-corticostriatal-adenosine-a2a-receptor-controls-maintenance-and-retrieval-of-spatial%C3%A2-working-memory
#8
Zhihui Li, Xingjun Chen, Tao Wang, Ying Gao, Fei Li, Long Chen, Jin Xue, Yan He, Yan Li, Wei Guo, Wu Zheng, Liping Zhang, Fenfen Ye, Xiangpeng Ren, Yue Feng, Piu Chan, Jiang-Fan Chen
BACKGROUND: Working memory (WM) taps into multiple executive processes including encoding, maintenance, and retrieval of information, but the molecular and circuit modulation of these WM processes remains undefined due to the lack of methods to control G protein-coupled receptor signaling with temporal resolution of seconds. METHODS: By coupling optogenetic control of the adenosine A2A receptor (A2AR) signaling, the Cre-loxP-mediated focal A2AR knockdown with a delayed non-match-to-place (DNMTP) task, we investigated the effect of optogenetic activation and focal knockdown of A2ARs in the dorsomedial striatum (n = 8 to 14 per group) and medial prefrontal cortex (n = 16 to 22 per group) on distinct executive processes of spatial WM...
August 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28882316/death-from-opioid-overdose-after-deep-brain-stimulation-a-case-report
#9
LETTER
Chencheng Zhang, Yuhua Huang, Fangchen Zheng, Kristina Zeljic, Jun Pan, Bomin Sun
No abstract text is available yet for this article.
August 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28888327/vicarious-social-defeat-stress-induces-depression-related-outcomes-in-female-mice
#10
Sergio D Iñiguez, Francisco J Flores-Ramirez, Lace M Riggs, Jason B Alipio, Israel Garcia-Carachure, Mirella A Hernandez, David O Sanchez, Mary Kay Lobo, Peter A Serrano, Stephen H Braren, Samuel A Castillo
BACKGROUND: Stress is a prevailing risk factor for mood-related illnesses, wherein women represent the majority of those affected by major depression. Despite the growing literature suggesting that affective disorders can arise after a traumatic event is vicariously experienced, this relationship remains understudied in female subjects at the preclinical level. Thus, the objective of the current investigation was to examine whether exposure to emotional and/or psychological stress (ES) mediates depression-related outcomes in female mice...
July 29, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28893381/the-association-between-prenatal-stress-and%C3%A2-externalizing-symptoms-in-childhood-evidence-from-the-avon-longitudinal-study-of%C3%A2-parents-and-children
#11
Nathalie MacKinnon, Mila Kingsbury, Liam Mahedy, Jonathan Evans, Ian Colman
BACKGROUND: It has been suggested that prenatal maternal stress may increase the risk of childhood externalizing disorders, yet no large cohort study has investigated this association across a large range of acute stressors. Our objective was to estimate the association between prenatal stressful events and risk of offspring conduct disorder and hyperactivity. METHODS: We used data from 10,184 mother-offspring pairs from the United Kingdom-based Avon Longitudinal Study of Parents and Children...
July 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28886759/epigenetic-regulation-of-the-kappa-opioid-receptor-by-child-abuse
#12
Pierre-Eric Lutz, Jeffrey A Gross, Sabine K Dhir, Gilles Maussion, Jennie Yang, Alexandre Bramoulle, Michael J Meaney, Gustavo Turecki
BACKGROUND: Experiences of abuse and neglect during childhood are major predictors of the emergence of depressive and suicidal behaviors throughout life. The underlying biological mechanisms, however, remain poorly understood. Here, we focused on the opioid system as a potential brain substrate mediating these effects. METHODS: Postmortem samples from three brain structures regulating social bonds and emotions were analyzed. Groups were constituted of depressed individuals who died by suicide, with or without a history of severe child abuse, and of psychiatrically healthy control subjects...
July 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28911901/structural-brain-abnormalities-of-attention-deficit-hyperactivity-disorder-with-oppositional-defiant-disorder
#13
Siri D S Noordermeer, Marjolein Luman, Corina U Greven, Kim Veroude, Stephen V Faraone, Catharina A Hartman, Pieter J Hoekstra, Barbara Franke, Jan K Buitelaar, Dirk J Heslenfeld, Jaap Oosterlaan
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with structural abnormalities in total gray matter, basal ganglia, and cerebellum. Findings of structural abnormalities in frontal and temporal lobes, amygdala, and insula are less consistent. Remarkably, the impact of comorbid oppositional defiant disorder (ODD) (comorbidity rates up to 60%) on these neuroanatomical differences is scarcely studied, while ODD (in combination with conduct disorder) has been associated with structural abnormalities of the frontal lobe, amygdala, and insula...
July 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28882317/persistent-increase-in-microglial-rage-contributes-to-chronic-stress-induced-priming-of-depressive-like-behavior
#14
Tina C Franklin, Eric S Wohleb, Yi Zhang, Manoela Fogaça, Brendan Hare, Ronald S Duman
BACKGROUND: Chronic stress-induced inflammatory responses occur in part via danger-associated molecular pattern (DAMP) molecules, such as high mobility group box 1 protein (HMGB1), but the receptor(s) underlying DAMP signaling have not been identified. METHODS: Microglia morphology and DAMP signaling in enriched rat hippocampal microglia were examined during the development and expression of chronic unpredictable stress (CUS)-induced behavioral deficits, including long-term, persistent changes after CUS...
July 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28842114/intergenerational-effect-of-maternal-exposure-to-childhood-maltreatment-on-newborn-brain-anatomy
#15
Nora K Moog, Sonja Entringer, Jerod M Rasmussen, Martin Styner, John H Gilmore, Norbert Kathmann, Christine M Heim, Pathik D Wadhwa, Claudia Buss
BACKGROUND: Childhood maltreatment (CM) confers deleterious long-term consequences, and growing evidence suggests some of these effects may be transmitted across generations. We examined the intergenerational effect of maternal CM exposure on child brain structure and also addressed the hypothesis that this effect may start during the child's intrauterine period of life. METHODS: A prospective longitudinal study was conducted in a clinical convenience sample of 80 mother-child dyads...
July 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28823710/no-evidence-that-schizophrenia-candidate-genes-are-more-associated-with-schizophrenia-than-noncandidate-genes
#16
Emma C Johnson, Richard Border, Whitney E Melroy-Greif, Christiaan A de Leeuw, Marissa A Ehringer, Matthew C Keller
BACKGROUND: A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other variants within those candidate genes that demonstrated genome-wide significant associations with schizophrenia. As such, it is possible that variants within historic schizophrenia candidate genes are associated with schizophrenia at levels above those expected by chance, even if the most-studied specific polymorphisms are not...
July 13, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28838559/late-life-depression-cortisol-and-the-hippocampus-on-the-need-to-consider-depressive-hippocampal-and-pharmacological-complexities
#17
LETTER
Renzo Bianchi, Eric Laurent
No abstract text is available yet for this article.
July 12, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28838558/reply-to-late-life-depression-cortisol-and-the-hippocampus-on-the-need-to-consider-depressive-hippocampal-and-pharmacological-complexities
#18
LETTER
Mirjam I Geerlings, Lotte Gerritsen
No abstract text is available yet for this article.
July 12, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28823711/positive-allosteric-modulation-of-cannabinoid-receptor-type-1-suppresses-pathological-pain-without-producing-tolerance-or-dependence
#19
Richard A Slivicki, Zhili Xu, Pushkar M Kulkarni, Roger G Pertwee, Ken Mackie, Ganesh A Thakur, Andrea G Hohmann
BACKGROUND: Activation of cannabinoid CB1 receptors suppresses pathological pain but also produces unwanted central side effects. We hypothesized that a positive allosteric modulator of CB1 signaling would suppress inflammatory and neuropathic pain without producing cannabimimetic effects or physical dependence. We also asked whether a CB1 positive allosteric modulator would synergize with inhibitors of endocannabinoid deactivation and/or an orthosteric cannabinoid agonist. METHODS: GAT211, a novel CB1 positive allosteric modulator, was evaluated for antinociceptive efficacy and tolerance in models of neuropathic and/or inflammatory pain...
July 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28778658/susceptibility-and-resilience-to-posttraumatic-stress-disorder-like-behaviors-in-inbred-mice
#20
Stephanie E Sillivan, Nadine F Joseph, Sarah Jamieson, Michelle L King, Itzamarie Chévere-Torres, Illeana Fuentes, Gleb P Shumyatsky, Alicia F Brantley, Gavin Rumbaugh, Courtney A Miller
BACKGROUND: The limited neurobiological understanding of posttraumatic stress disorder (PTSD) has been partially attributed to the need for improved animal models. Stress-enhanced fear learning (SEFL) in rodents recapitulates many PTSD-associated behaviors, including stress-susceptible and stress-resilient subgroups in outbred rats. Identification of subgroups requires additional behavioral phenotyping, a confound to mechanistic studies. METHODS: We employed a SEFL paradigm in inbred male and female C57BL/6 mice that combines acute stress with fear conditioning to precipitate traumatic-like memories...
July 8, 2017: Biological Psychiatry
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