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Journal of Membrane Biology

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https://www.readbyqxmd.com/read/28434115/interaction-of-selected-phenylpropenes-with-dipalmitoylphosphatidylcholine-membrane-and-their-relevance-to-antibacterial-activity
#1
Riham Gharib, Amal Najjar, Lizette Auezova, Catherine Charcosset, Hélène Greige-Gerges
The effect of structurally closely related phenylpropenes (PPs), estragole, anethole, eugenol, and isoeugenol, on the fluidity of dipalmitoyl phosphatidyl choline (DPPC) liposome membrane was investigated by DSC, Raman, and fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH). Liposomes were prepared by thin-film hydration method at various DPPC:PP molar ratios. The DPH anisotropy measurements of blank and PP-loaded liposomes were performed at 28, 41, and 50 °C, which correspond, respectively, to gel phase, main transition temperature of DPPC, and liquid phase...
April 22, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28417145/relationship-in-pacemaker-neurons-between-the-long-term-correlations-of-membrane-voltage-fluctuations-and-the-corresponding-duration-of-the-inter-spike-interval
#2
Alberto Seseña Rubfiaro, José Rafael Godínez, Juan Carlos Echeverría
Several studies of the behavior in the voltage and frequency fluctuations of the neural electrical activity have been performed. Here, we explored the particular association between behavior of the voltage fluctuations in the inter-spike segment (VFIS) and the inter-spike intervals (ISI) of F1 pacemaker neurons from H. aspersa, by disturbing the intracellular calcium handling with cadmium and caffeine. The scaling exponent α of the VFIS, as provided by detrended fluctuations analysis, in conjunction with the corresponding duration of ISI to estimate the determination coefficient R (2) (48-50 intervals per neuron, N = 5) were all evaluated...
April 17, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28386629/an-in-vitro-study-of-the-antioxidant-and-antihemolytic-properties-of-buddleja-globosa-matico
#3
Mario Suwalsky, José Duguet, Hernán Speisky
The antioxidant and antihemolytic properties contained in the leaves of Buddleja globosa (B. globosa), also known as "Matico," were determined. Aqueous extracts of leaves were assayed in human erythrocytes and molecular models of its membrane. The latter were bilayers built-up of lipids located in the outer and inner leaflets of the erythrocyte membrane. Observations by scanning electron microscopy showed that the extract altered the morphology of erythrocytes inducing the formation of crenated echinocytes...
April 6, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28280854/deficiency-in-sperm-egg-protein-interaction-as-a-major-cause-of-fertilization-failure
#4
REVIEW
Soudabeh Sabetian, Mohd Shahir Shamsir
Complete elucidation of fertilization process at molecular level is one of the unresolved challenges in sexual reproduction studies, and understanding the molecular mechanism is crucial in overcoming difficulties in infertility and unsuccessful in vitro fertilization. Sperm-oocyte interaction is one of the most remarkable events in fertilization process, and deficiency in protein-protein interactions which mediate this interaction is a major cause of unexplained infertility. Due to detection of how the various defects of sperm-oocyte interaction can affect fertilization failure, different experimental methods have been applied...
March 9, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28251264/calcium-induced-mitochondrial-permeability-transitions-parameters-of-ca-2-ion-interactions-with-mitochondria-and-effects-of-oxidative-agents
#5
Nina G Golovach, Vitali T Cheshchevik, Elena A Lapshina, Tatsiana V Ilyich, Ilya B Zavodnik
We evaluated the parameters of Ca(2+)-induced mitochondrial permeability transition (MPT) pore formations, Ca(2+) binding constants, stoichiometry, energy of activation, and the effect of oxidative agents, tert-butyl hydroperoxide (tBHP), and hypochlorous acid (HOCl), on Ca(2+) -mediated process in rat liver mitochondria. From the Hill plot of the dependence of MPT rate on Ca(2+) concentration, we determined the order of interaction of Ca(2+) ions with the mitochondrial sites, n = 3, and the apparent Kd = 60 ± 12 µM...
March 1, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28238117/membrane-permeabilization-of-pathogenic-yeast-in-alternating-sub-microsecond-electromagnetic-fields-in-combination-with-conventional-electroporation
#6
Vitalij Novickij, Eglė Lastauskienė, Jurgita Švedienė, Audrius Grainys, Gediminas Staigvila, Algimantas Paškevičius, Irutė Girkontaitė, Auksė Zinkevičienė, Svetlana Markovskaja, Jurij Novickij
Recently, a novel contactless treatment method based on high-power pulsed electromagnetic fields (PEMF) was proposed, which results in cell membrane permeabilization effects similar to electroporation. In this work, a new PEMF generator based on multi-stage Marx circuit topology, which is capable of delivering 3.3 T, 0.19 kV/cm sub-microsecond pulses was used to permeabilize pathogenic yeast Candida albicans separately and in combination with conventional square wave electroporation (8-17 kV/cm, 100 μs)...
February 25, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28229180/erratum-to-high-resolution-structure-of-a-membrane-protein-transferred-from-amphipol-to-a-lipidic-mesophase
#7
V Polovinkin, I Gushchin, M Sintsov, E Round, T Balandin, P Chervakov, V Shevchenko, P Utrobin, A Popov, V Borshchevskiy, A Mishin, A Kuklin, D Willbold, V Chupin, J-L Popot, V Gordeliy
No abstract text is available yet for this article.
February 22, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28224174/spectroscopic-polarographic-and-microcalorimetric-studies-on-mitochondrial-dysfunction-induced-by-ethanol
#8
Long Ma, Jia-Xin Dong, Can Wu, Xue-Yi Li, Jing Chen, Hong Zhang, Yi Liu
Liver mitochondria are involved in several important life processes; mitochondrial dysfunction and disorders are implicated in several human diseases. Alcohol permeates all tissues of the body and exerts some intrinsic hepatotoxicity. In this work, our results demonstrated that ethanol caused a series of mitochondria permeability transition pore (MPTP) opening factors such as mitochondrial swelling, increased permeability of H(+) and K(+), collapsed membrane potential, and increased membrane fluidity. Furthermore, mitochondrial ultrastructure alternation observed clearly by transmission electron microscopy and the release of Cytochrome c could explain the MPTP opening from another aspect...
February 21, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28214974/interaction-of-scots-pine-defensin-with-model-membrane-by-coarse-grained-molecular-dynamics
#9
Elena Ermakova, Yuriy Zuev
Plant defensins are a part of the innate immune system of plants that acts against a broad range of pathogens. Many plant defensins, including pine defensins, show strong antifungal activity that is associated with their ability to penetrate into the fungal cell membrane. However, the exact molecular mechanism of their action remains poorly defined. To obtain insight into the mechanism of protein-membrane interaction, we applied a coarse-grained molecular dynamics simulation to study the interaction of pine defensin with two model membranes: the first consisted of zwitterion-neutral POPC molecules and the second was composed of combined anionic POPG and POPC...
February 18, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28204840/inhibition-of-the-innate-immune-receptors-for-foreign-dna-sensing-improves-transfection-efficiency-of-gene-electrotransfer-in-melanoma-b16f10-cells
#10
Masa Bosnjak, Urska Kamensek, Gregor Sersa, Danijela Stolfa, Jaka Lavrencak, Maja Cemazar
Gene electrotransfer upregulate DNA pattern recognition receptors or DNA sensors, which are part of the innate immune system. In this study, we tested if addition of the cocktail of innate immune system inhibitors to the cells during gene electrotransfer (GET) can increase transfection efficiency and cell survival. The results indicate that this cocktail can decrease cytosolic DNA sensors expression after GET, and consequently increase cell survival and transfection efficiency in B16 cells, but only in highly metastatic B16F10 subtype...
February 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28160046/eag1-voltage-dependent-potassium-channels-structure-electrophysiological-characteristics-and-function-in-cancer
#11
REVIEW
Xuzhao Wang, Yafei Chen, Yuhong Zhang, Shuai Guo, Li Mo, Hailong An, Yong Zhan
Eag1 (ether-à-go-go-1), a member of the voltage-dependent potassium channel family, is expressed mainly in the brain, and at low levels in placenta, testis, and adrenal gland, and only transiently in myoblasts. Recently, several studies have suggested that Eag1 is selectively expressed in various tumor tissues. Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis. Therefore, it has become a new molecular target for tumor diagnosis, prognosis evaluation, and tumor-targeted therapy...
February 3, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28243693/effect-of-cooling-on-cell-volume-and-viability-after-nanoelectroporation
#12
Claudia Muratori, Andrei G Pakhomov, Olga N Pakhomova
Electric pulses of nanosecond duration (nsEP) are emerging as a new modality for tissue ablation. Plasma membrane permeabilization by nsEP may cause osmotic imbalance, water uptake, cell swelling, and eventual membrane rupture. The present study was aimed to increase the cytotoxicity of nsEP by fostering water uptake and cell swelling. This aim was accomplished by lowering temperature after nsEP application, which delayed the membrane resealing and/or suppressed the cell volume mechanisms. The cell diameter in U-937 monocytes exposed to a train of 50, 300-ns pulses (100 Hz, 7 kV/cm) at room temperature and then incubated on ice for 30 min increased by 5...
April 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28239748/%C3%AE-synuclein-s-uniquely-long-amphipathic-helix-enhances-its-membrane-binding-and-remodeling-capacity
#13
Anthony R Braun, Michael M Lacy, Vanessa C Ducas, Elizabeth Rhoades, Jonathan N Sachs
α-Synuclein is the primary protein found in Lewy bodies, the protein and lipid aggregates associated with Parkinson's disease and Lewy body dementia. The protein folds into a uniquely long amphipathic α-helix (AH) when bound to a membrane, and at high enough concentrations, it induces large-scale remodeling of membranes (tubulation and vesiculation). By engineering a less hydrophobic variant of α-Synuclein, we previously showed that the energy associated with binding of α-Synuclein's AH correlates with the extent of membrane remodeling (Braun et al...
April 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28116481/a-new-spectral-approach-on-steady-state-concentration-of-species-in-porous-catalysts-using-wavelets
#14
M Mahalakshmi, G Hariharan
In this paper, a mathematical model of steady-state reaction-diffusion (RD) model for estimating the concentration of species is discussed. We have applied a new wavelet-based operational matrix of derivative method to obtain the approximate solutions for nonlinear RDEs. The proposed method is a powerful and easy-to-use analytical tool for linear and nonlinear problems. Some illustrative examples are given to validate our results with exact solutions. Satisfactory agreement with the exact solution is noticed...
January 23, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28083649/reassessment-of-glut7-and-glut9-as-putative-fructose-and-glucose-transporters
#15
Karolin Ebert, Maren Ludwig, Kerstin Elisabeth Geillinger, Gina Catalina Schoberth, Jasmin Essenwanger, Jürgen Stolz, Hannelore Daniel, Heiko Witt
Although increased dietary fructose consumption is associated with metabolic impairments, the mechanisms and regulation of intestinal fructose absorption are poorly understood. GLUT5 is considered to be the main intestinal fructose transporter. Other GLUT family members, such as GLUT7 and GLUT9 are also expressed in the intestine and were shown to transport fructose and glucose. A conserved isoleucine-containing motif (NXI) was proposed to be essential for fructose transport capacity of GLUT7 and GLUT9 but also of GLUT2 and GLUT5...
January 12, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28025687/characterisation-of-the%C3%A2-daacs%C3%A2-family-escherichia-coli-glutamate-aspartate-proton-symporter-gltp-using-computational-chemical-biochemical-and-biophysical-methods
#16
Moazur Rahman, Fouzia Ismat, Li Jiao, Jocelyn M Baldwin, David J Sharples, Stephen A Baldwin, Simon G Patching
Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins. A range of computational, chemical, biochemical and biophysical methods characterised evolutionary relationships, structural features, substrate binding affinities and transport kinetics of wild-type and mutant forms of GltP. Sequence alignments and phylogenetic analysis revealed close homologies of GltP with human glutamate transporters involved in neurotransmission, neutral amino acid transporters and with the archaeal aspartate transporter GltPh...
December 26, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27933338/progress-in-research-and-application-of-hiv-1-tat-derived-cell-penetrating-peptide
#17
REVIEW
Le Zou, Qilin Peng, Ping Wang, Boting Zhou
Human immunodeficiency virus type I (HIV-1) transactivator of transcription (TAT) is encoded by HIV-1. It is a peptide rich in basic amino acids and belongs to the protein transduction domain family. It has been found that HIV-1 TAT and its core peptide segment TAT47-57 play an important role in promoting the cellular uptake of coupled bioactive macromolecules, such as peptides, proteins, oligonucleotides, and drug molecules. HIV-1 TAT can also significantly increase the soluble expression of extrinsic proteins...
December 8, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27913823/mathematical-models-suggest-facilitated-fatty-acids-crossing-of-the-luminal-membrane-in-the-cardiac-muscle
#18
Efrath Barta
Long-chain fatty acids cross a few membranes on their way from the capillary blood to the cardiomyocyte cytosol, where they are utilized as an essential source of energy. Details of the transport mechanism across those membranes remained elusive despite decades of laboratory and theoretical work. Here we inspect several optional scenarios for the crossing of the luminal membrane of the endothelial cell, the first barrier that should be crossed: a passive diffusion, facilitation by receptors for albumin and facilitation by fatty acids transporters...
December 3, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27812737/iafp-ense-an-ensemble-classifier-for-identifying-antifreeze-protein-by-incorporating-grey-model-and-pssm-into-pseaac
#19
Xuan Xiao, Mengjuan Hui, Zi Liu
Antifreeze proteins (AFPs), known as thermal hysteresis proteins, are ice-binding proteins. AFPs have been found in many fields such as in vertebrates, invertebrates, plants, bacteria, and fungi. Although the function of AFPs is common, the sequences and structures of them show a high degree of diversity. AFPs can be adsorbed in ice crystal surface and inhibit the growth of ice crystals in solution. However, the interaction between AFPs and ice crystal is not completely known for human beings. It is vitally significant to propose an automated means as a high-throughput tool to timely identify the AFPs...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27803961/the-effect-of-benzyl-alcohol-on-the-dielectric-structure-of-lipid-bilayers
#20
Hadeel Alobeedallah, Bruce Cornell, Hans Coster
Molecularly tethered lipid bilayer membranes were constructed on a commercially available chemically modified gold substrate. This is a new and promising product that has allowed the construction of very robust lipid bilayers. Very high resolution electrical impedance spectroscopy (EIS) was used to determine the dielectric structure of the lipid bilayers and associated interfaces. The EIS data were modelled in terms of the dielectric substructure using purpose developed software. The hydrophobic region, where the lipid tails are located, was revealed by the EIS in the frequency range of (1-100) Hz and its thickness was calculated from the capacitance of this region and found to be approximately 3-4 nm...
December 2016: Journal of Membrane Biology
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