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Journal of Membrane Biology

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https://www.readbyqxmd.com/read/29147828/a-reliable-spectral-method-to-reaction-diffusion-equations-in-entrapped-cell-photobioreactor-packed-with-gel-granules-using-chebyshev-wavelets
#1
M Salai Mathi Selvi, G Hariharan, K Kannan
A mathematical model of a reaction-diffusion within an entrapped-cell photobioreactor packed with gel granules containing immobilized photosynthetic bacterial cells is discussed. A theoretical model is based on a system of coupled nonlinear reaction-diffusion equations. In this research work, we have developed an efficient wavelet-based spectral approach for solving the proposed model. Analytical expressions for the concentration of substrate and product are established for all values of reaction-diffusion parameters using second kind Chebyshev wavelet method...
November 17, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29143077/calcein-release-from-cells-in-vitro-via-reversible-and-irreversible-electroporation
#2
Violeta Rajeckaitė, Baltramiejus Jakštys, Arnas Rafanavičius, Martynas Maciulevičius, Milda Jakutavičiūtė, Saulius Šatkauskas
The aim of this study was to investigate the dependence of calcein extraction and cell viability on the parameters of pulsed electric field (PEF). Two different approaches concerning PEF parameters were investigated: (1) extraction efficiency and cell viability dependence on pulse number, exploiting 1200 V/cm 100 µs duration high voltage (HV) electric pulses and (2) extraction efficiency and cell viability dependence on the pulses with different duration (44-400 µs) and electric field strength (600-1800 V/cm) that result in the same amount of electric field energy delivered to Chinese hamster ovary cells...
November 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29127488/the-influence-of-synthesis-parameters-on-vertically-aligned-cnt-sheets-empirical-modeling-and-process-optimization-using-response-surface-methodology
#3
Seyed Mohsen Hosseini, Vahid Pirouzfar, Hamed Azami
In the present work, vertically aligned carbon nanotube (VA-CNT) sheets were synthesized via pyrolysis of polybenzimidazole (PBI)-Kapton inside the pores of anodized aluminum oxide (AAO). The synthesized VA-CNT sheets were then evaluated for the desalination of salty water. The results indicated that the VA-CNT sheets were effective for application as an adsorbent for desalination of salty water due to their high adsorption capacity, with no loss of CNTs in the treated water. This study explored the impact of operating time and temperature on liquid adsorption performance through optimization and modeling methods...
November 10, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29127487/towards-a-unified-understanding-of-lithium-action-in-basic-biology-and-its-significance-for-applied-biology
#4
REVIEW
Eric Jakobsson, Orlando Argüello-Miranda, See-Wing Chiu, Zeeshan Fazal, James Kruczek, Santiago Nunez-Corrales, Sagar Pandit, Laura Pritchet
Lithium has literally been everywhere forever, since it is one of the three elements created in the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from place to place, and has varied widely in specific regions over evolutionary and geologic time. The biological effects of lithium are many and varied. Based on experiments in which animals are deprived of lithium, lithium is an essential nutrient. At the other extreme, at lithium ingestion sufficient to raise blood concentration significantly over 1 mM/, lithium is acutely toxic...
November 10, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29127486/crosstalk-of-nanosystems-induced-extracellular-vesicles-as-promising-tools-in-biomedical-applications
#5
REVIEW
Gamaleldin I Harisa, Mohamed M Badran, Fars K Alanazi, Sabry M Attia
Hybrid vesicles are considered as a bridge between natural nanosystems (NNSs) and artificial nanosystems (ANSs). NNSs are extracellular vesicles (EVs), membranous, bio-formed endogenously, which act as endogenous cargoes, and reflecting cellular dynamics. EVs have cellular tropism, permeate tight junctions, and are non-immunogenic. EVs are used as tools in the development of diagnostic and therapeutic agents. ANSs can induce biogenesis of hybrid vesicles as promising smart diagnostic agents, and innovative drug cargoes...
November 10, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29098331/essential-two-component-systems-regulating-cell-envelope-functions-opportunities-for-novel-antibiotic-therapies
#6
Silvia T Cardona, Matthew Choy, Andrew M Hogan
Novel therapies are urgently needed to alleviate the current crisis of multiple drug-resistant infections. The bacterial signal transduction mechanisms, known as two-component systems (TCSs), are ideal targets of novel inhibitory molecules. Highly restricted to the bacterial world, TCSs control a diverse set of cellular functions, namely virulence, response to cell envelope stress, and drug efflux. Impaired regulation of any of these aspects could affect the susceptibility of bacterial pathogens to antibiotics, which highlights the potential of TCS as targets of antibiotic adjuvant therapies...
November 2, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29098330/mycobacterial-membrane-proteins-qcrb-and-atpe-roles-in-energetics-antibiotic-targets-and-associated-mechanisms-of-resistance
#7
Luke Bown, Santosh K Srivastava, Brandon M Piercey, Clarissa K McIsaac, Kapil Tahlan
Infections caused by mycobacteria are difficult to treat due to their inherent physiology, cellular structure, and intracellular lifestyle. Mycobacterium tuberculosis is a pathogen of global concern as it causes tuberculosis (TB) in humans, which requires 6-9 months of chemotherapy. The situation is further exacerbated in the case of infections caused by drug-resistant strains, which necessitate the prolonged use of agents associated with increased host toxicities. Great effort has been invested into the development of new agents for the treatment of drug-resistant infections, in addition to novel strategies to reduce treatment time...
November 2, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29094194/permeabilizing-phospholipid-bilayers-with-non-normal-electric-fields
#8
F Castellani, J Teissié, P T Vernier
Since 2003, molecular dynamics simulations of lipid bilayers have provided valuable insights into the mechanisms underlying electropermeabilization (electroporation)-an electric field-induced increase in the permeability of biological membranes. The convention in these studies has been to apply the electric field normal to the plane of the membrane. In a typical electroporation application, however, where the electric field is reasonably uniform and unidirectional, the field is perpendicular to the membrane only at a few locations-for spherical cells only at the poles of the cells along the axis defined by the direction of the electric field...
November 1, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29063141/cmpx-affects-virulence-in-pseudomonas-aeruginosa-through-the-gac-rsm-signaling-pathway-and-by-modulating-c-di-gmp-levels
#9
Anjali Y Bhagirath, Deepti Somayajula, Yanqi Li, Kangmin Duan
Pseudomonas aeruginosa is an ubiquitous organism which is able to infect and colonize many types of hosts including humans. Colonization of P. aeruginosa in chronic infections leads to the formation of biofilms, which are difficult to eradicate. P. aeruginosa is capable of regulating its virulence factors in response to external environment triggers and its signaling mechanism involves two-component regulatory systems and small molecules such as bis-(3'-5')-cyclic dimeric guanosine monophosphate. PA1611-RetS-GacS/A-RsmA/Y/Z is a key regulatory pathway in P...
October 23, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29063140/biocide-selective-tolc-independent-efflux-pumps-in-enterobacteriaceae
#10
Carmine J Slipski, George G Zhanel, Denice C Bay
Bacterial resistance to biocides used as antiseptics, dyes, and disinfectants is a growing concern in food preparation, agricultural, consumer manufacturing, and health care industries, particularly among Gram-negative Enterobacteriaceae, some of the most common community and healthcare-acquired bacterial pathogens. Biocide resistance is frequently associated with antimicrobial cross-resistance leading to reduced activity and efficacy of both antimicrobials and antiseptics. Multidrug resistant efflux pumps represent an important biocide resistance mechanism in Enterobacteriaceae...
October 23, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28993850/expression-of-collagenase-is-regulated-by-the-vars-vara-two-component-regulatory-system-in-vibrio-alginolyticus
#11
Takehiko Mima, Kazuyoshi Gotoh, Yumiko Yamamoto, Keiko Maeda, Taku Shirakawa, Shunsuke Matsui, Yumi Murata, Takaki Koide, Hiroshi Tokumitsu, Osamu Matsushita
Vibrio alginolyticus is an opportunistic pathogen in both humans and marine animals. Collagenase encoded by colA is considered to be one of the virulence factors. Expression of colA is regulated by multiple environmental factors, e.g., temperature, growth phase, and substrate. To elucidate the mechanism of regulation of colA expression, transposon mutagenesis was performed. VarS, a sensor histidine kinase of the two-component regulatory system, was demonstrated to regulate the expression of colA. VarA, a cognate response regulator of VarS, was also identified and shown to be involved in the regulation of colA expression...
October 9, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28988287/kinetic-measurements-of-di-and-tripeptide-and-peptidomimetic-drug-transport-in-different-kidney-regions-using-the-fluorescent-membrane-potential-sensitive-dye-dis-c3-3
#12
Othman A Alghamdi, Nicola King, Graham L Jones, Pierre D J Moens
Tri- and dipeptides are transported in the kidney by PEPT1 and PEPT2 isoforms. The aim of this study was to investigate differences in transport kinetics between renal brush border (BBMV) and outer medulla (OMMV) membrane vesicles (where PEPT1 and PEPT2 are sequentially available) for a range of di- and tripeptides and peptidomimetic drugs. This was accomplished through the use of the potential-sensitive fluorescent dye 3,3'-dipropylthiacarbocyanine iodide [DiS-C3-(3)]. BBMV and OMMV were prepared from the rat kidney using standard techniques...
October 7, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28975384/the-two-operon-coded-abc-transporter-complex-fpvwxyzcdef-is-required-for-pseudomonas-aeruginosa-growth-and-virulence-under-iron-limiting-conditions
#13
Lang Gao, Zisheng Guo, Yue Wang, Yulu Wang, Kerong Wang, Bo Li, Lixin Shen
Iron is essential for all organisms. Bacteria have devolved sophisticated systems to maintain intracellular iron homeostasis. FpvCDEF(PA2407-2410) has been reported as an ABC transporter involved in pyoverdine-Fe uptake which does not affect growth under iron-limiting condition, when it is deleted in PAO1. In this study, we proved that fpvCDEF and fpvWXYZ(PA2403-2406) constituted an ABC transporter complex containing two operons: fpvWXYZCDE and fpvF. The operon fpvWXYZCDE was regulated by iron negatively and the single gene operon fpvF was constitutively expressed...
October 3, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28914342/quantification-of-the-intracellular-life-time-of-water-molecules-to-measure-transport-rates-of-human-aquaglyceroporins
#14
Madelene Palmgren, Malin Hernebring, Stefanie Eriksson, Karin Elbing, Cecilia Geijer, Samo Lasič, Peter Dahl, Jesper S Hansen, Daniel Topgaard, Karin Lindkvist-Petersson
Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the yeast Pichia pastoris, where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins...
September 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28894900/interaction-between-luteinizing-hormone-releasing-hormone-and-gm1-doped-cholesterol-sphingomyelin-vesicles-a-spectroscopic-study
#15
Zarrin Shahzadi, Chaitali Mukhopadhyay
Understanding the role of neural membrane in translocation and action of neurohormone is of great importance. Luteinizing hormone-releasing hormone (LHRH) is a neuropeptide hormone and it acts as a final signaling molecule by stimulating the synthesis of LH and FSH to maintain reproduction in all vertebrates. The receptors of LHRH are found in breast tumors and pituitary gland in the brain. Moreover, neural plasma membrane is also found to contain specific binding site for LHRH. The mechanism by which LHRH binds to membrane before it binds to the receptors is a very critical step and can have a profound impact upon the translation of peptide across the membrane...
September 11, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28866739/effect-of-sodium-chloride-on-surface-associated-motility-of-acinetobacter-baumannii-and-the-role-of-aders-two-component-system
#16
P Malaka De Silva, Ayush Kumar
Acinetobacter baumannii is an important bacterial pathogen whose resistance to antibiotics is a growing concern worldwide. Among a wide array of resistance mechanisms displayed by A. baumannii, energy-dependent efflux of antibiotics by proteins belonging the resistance-nodulation-division family serves as an important one. AdeABC pump has been shown to be active in various clinical isolates. Regulation of this pump is controlled by the AdeRS two-component system. In this study, we show that the AdeRS system, in addition to modulating A...
September 2, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28852815/mycobacterium-tuberculosis-major-facilitator-superfamily-transporters
#17
REVIEW
Ping Li, Yinzhong Gu, Jiang Li, Longxiang Xie, Xue Li, Jianping Xie
The cell membrane or biofilm serve as permeable barrier for xenobiotics to maintain the homeostasis of cells or bacterial community. Transport systems are essential for the uptake of nutrients and substances necessary for biofilm formation, efflux of deleterious compounds, as well as communication between cells and environment. Major facilitator superfamily (MFS) represents the largest secondary transporter family and is responsible for the transport of a broad spectrum of substrates with diverse physiochemical properties by utilizing the energy stored in electrochemical gradient across the membrane...
August 29, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28887642/evaluation-of-the-functional-capacity-of-nk-cells-of-melanoma-patients-in-an-in-vitro-model-of-nk-cell-contact-with-k562-and-femx-tumor-cell-lines
#18
Gordana Konjevic, Ana Vuletic, Katarina Mirjacic Martinovic, Ana Krivokuca, Radmila Jankovic, Nada Babovic
NK cells of metastatic melanoma (MM) patients display impaired function, making them incapable to mount an effective antitumor response. In this study, we evaluated immunophenotypic characteristics and functional capacity of CD3(-)CD16(+) NK cells of MM patients in an in vitro model based on NK cell contact with an NK sensitive, K562, and a tumor-specific, melanoma FemX tumor cell line. Although our results indicate similar NK cell antitumor cytotoxic potential of MM patients in contact with both cell lines based on the expression of CD107a degranulation marker, there is a discrepancy in NK cell IFNγ production, as it is not significantly induced by FemX tumor cells, found to be, contrary to K562, HLA class I positive...
October 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28871398/effect-of-pulsed-electric-fields-pef-on-accumulation-of-magnesium-in-lactobacillus-rhamnosus-b-442-cells
#19
Małgorzata Góral, Urszula Pankiewicz
The aim of this study was to determine the effect of pulsed electric fields (PEF) on accumulation of magnesium ions in Lactobacillus rhamnosus B 442 cells. Under optimized conditions, this is, on 15 min exposure of the 20 h grown culture to PEF of the 2.0 kV/cm and 20 µs pulse width at concentration 400 μg Mg(2+)/mL medium, accumulation of magnesium in the biomass reached maximum 4.28 mg/g d.m. Optimization of PEF parameters caused an increase of magnesium concentration in the cells by 220% in comparison to the control not treated with PEF...
October 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28861595/oxysterols-versus-cholesterol-in-model-neuronal-membrane-i-the-case-of-7-ketocholesterol-the-langmuir-monolayer-study
#20
Anita Wnętrzak, Katarzyna Makyła-Juzak, Anna Filiczkowska, Waldemar Kulig, Patrycja Dynarowicz-Łątka
Oxysterols are products of cholesterol oxidation. They can be formed endogenously (in both enzymatic and non-enzymatic reactions) as well as exogenously (delivered with food). Recent studies clearly demonstrate cytotoxic properties of these compounds, being mainly due to their incorporation into natural lipid bilayers. This process can influence mechanical and physicochemical properties of biomembrane-mainly by modifying the interactions between its components, which may result in the disruption of proper functioning of cell membrane and could lead to its degradation...
October 2017: Journal of Membrane Biology
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