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Journal of Membrane Biology

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https://www.readbyqxmd.com/read/28229180/erratum-to-high-resolution-structure-of-a-membrane-protein-transferred-from-amphipol-to-a-lipidic-mesophase
#1
V Polovinkin, I Gushchin, M Sintsov, E Round, T Balandin, P Chervakov, V Shevchenko, P Utrobin, A Popov, V Borshchevskiy, A Mishin, A Kuklin, D Willbold, V Chupin, J-L Popot, V Gordeliy
No abstract text is available yet for this article.
February 22, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28224174/spectroscopic-polarographic-and-microcalorimetric-studies-on-mitochondrial-dysfunction-induced-by-ethanol
#2
Long Ma, Jia-Xin Dong, Can Wu, Xue-Yi Li, Jing Chen, Hong Zhang, Yi Liu
Liver mitochondria are involved in several important life processes; mitochondrial dysfunction and disorders are implicated in several human diseases. Alcohol permeates all tissues of the body and exerts some intrinsic hepatotoxicity. In this work, our results demonstrated that ethanol caused a series of mitochondria permeability transition pore (MPTP) opening factors such as mitochondrial swelling, increased permeability of H(+) and K(+), collapsed membrane potential, and increased membrane fluidity. Furthermore, mitochondrial ultrastructure alternation observed clearly by transmission electron microscopy and the release of Cytochrome c could explain the MPTP opening from another aspect...
February 21, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28214974/interaction-of-scots-pine-defensin-with-model-membrane-by-coarse-grained-molecular-dynamics
#3
Elena Ermakova, Yuriy Zuev
Plant defensins are a part of the innate immune system of plants that acts against a broad range of pathogens. Many plant defensins, including pine defensins, show strong antifungal activity that is associated with their ability to penetrate into the fungal cell membrane. However, the exact molecular mechanism of their action remains poorly defined. To obtain insight into the mechanism of protein-membrane interaction, we applied a coarse-grained molecular dynamics simulation to study the interaction of pine defensin with two model membranes: the first consisted of zwitterion-neutral POPC molecules and the second was composed of combined anionic POPG and POPC...
February 18, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28204840/inhibition-of-the-innate-immune-receptors-for-foreign-dna-sensing-improves-transfection-efficiency-of-gene-electrotransfer-in-melanoma-b16f10-cells
#4
Masa Bosnjak, Urska Kamensek, Gregor Sersa, Danijela Stolfa, Jaka Lavrencak, Maja Cemazar
Gene electrotransfer upregulate DNA pattern recognition receptors or DNA sensors, which are part of the innate immune system. In this study, we tested if addition of the cocktail of innate immune system inhibitors to the cells during gene electrotransfer (GET) can increase transfection efficiency and cell survival. The results indicate that this cocktail can decrease cytosolic DNA sensors expression after GET, and consequently increase cell survival and transfection efficiency in B16 cells, but only in highly metastatic B16F10 subtype...
February 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28160046/eag1-voltage-dependent-potassium-channels-structure-electrophysiological-characteristics-and-function-in-cancer
#5
REVIEW
Xuzhao Wang, Yafei Chen, Yuhong Zhang, Shuai Guo, Li Mo, Hailong An, Yong Zhan
Eag1 (ether-à-go-go-1), a member of the voltage-dependent potassium channel family, is expressed mainly in the brain, and at low levels in placenta, testis, and adrenal gland, and only transiently in myoblasts. Recently, several studies have suggested that Eag1 is selectively expressed in various tumor tissues. Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis. Therefore, it has become a new molecular target for tumor diagnosis, prognosis evaluation, and tumor-targeted therapy...
February 3, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28116481/a-new-spectral-approach-on-steady-state-concentration-of-species-in-porous-catalysts-using-wavelets
#6
M Mahalakshmi, G Hariharan
In this paper, a mathematical model of steady-state reaction-diffusion (RD) model for estimating the concentration of species is discussed. We have applied a new wavelet-based operational matrix of derivative method to obtain the approximate solutions for nonlinear RDEs. The proposed method is a powerful and easy-to-use analytical tool for linear and nonlinear problems. Some illustrative examples are given to validate our results with exact solutions. Satisfactory agreement with the exact solution is noticed...
January 23, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28083649/reassessment-of-glut7-and-glut9-as-putative-fructose-and-glucose-transporters
#7
Karolin Ebert, Maren Ludwig, Kerstin Elisabeth Geillinger, Gina Catalina Schoberth, Jasmin Essenwanger, Jürgen Stolz, Hannelore Daniel, Heiko Witt
Although increased dietary fructose consumption is associated with metabolic impairments, the mechanisms and regulation of intestinal fructose absorption are poorly understood. GLUT5 is considered to be the main intestinal fructose transporter. Other GLUT family members, such as GLUT7 and GLUT9 are also expressed in the intestine and were shown to transport fructose and glucose. A conserved isoleucine-containing motif (NXI) was proposed to be essential for fructose transport capacity of GLUT7 and GLUT9 but also of GLUT2 and GLUT5...
January 12, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28025687/characterisation-of-the%C3%A2-daacs%C3%A2-family-escherichia-coli-glutamate-aspartate-proton-symporter-gltp-using-computational-chemical-biochemical-and-biophysical-methods
#8
Moazur Rahman, Fouzia Ismat, Li Jiao, Jocelyn M Baldwin, David J Sharples, Stephen A Baldwin, Simon G Patching
Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins. A range of computational, chemical, biochemical and biophysical methods characterised evolutionary relationships, structural features, substrate binding affinities and transport kinetics of wild-type and mutant forms of GltP. Sequence alignments and phylogenetic analysis revealed close homologies of GltP with human glutamate transporters involved in neurotransmission, neutral amino acid transporters and with the archaeal aspartate transporter GltPh...
December 26, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27933338/progress-in-research-and-application-of-hiv-1-tat-derived-cell-penetrating-peptide
#9
REVIEW
Le Zou, Qilin Peng, Ping Wang, Boting Zhou
Human immunodeficiency virus type I (HIV-1) transactivator of transcription (TAT) is encoded by HIV-1. It is a peptide rich in basic amino acids and belongs to the protein transduction domain family. It has been found that HIV-1 TAT and its core peptide segment TAT47-57 play an important role in promoting the cellular uptake of coupled bioactive macromolecules, such as peptides, proteins, oligonucleotides, and drug molecules. HIV-1 TAT can also significantly increase the soluble expression of extrinsic proteins...
December 8, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27913823/mathematical-models-suggest-facilitated-fatty-acids-crossing-of-the-luminal-membrane-in-the-cardiac-muscle
#10
Efrath Barta
Long-chain fatty acids cross a few membranes on their way from the capillary blood to the cardiomyocyte cytosol, where they are utilized as an essential source of energy. Details of the transport mechanism across those membranes remained elusive despite decades of laboratory and theoretical work. Here we inspect several optional scenarios for the crossing of the luminal membrane of the endothelial cell, the first barrier that should be crossed: a passive diffusion, facilitation by receptors for albumin and facilitation by fatty acids transporters...
December 3, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27904934/part-2-analytical-expressions-of-concentrations-of-glucose-oxygen-and-gluconic-acid-in-a-composite-membrane-for-closed-loop-insulin-delivery-for-the-non-steady-state-conditions
#11
N Mehala, L Rajendran, V Meena
A mathematical model developed by Abdekhodaie and Wu (J Membr Sci 335:21-31, 2009), which describes a dynamic process involving an enzymatic reaction and diffusion of reactants and product inside glucose-sensitive composite membrane has been discussed. This theoretical model depicts a system of non-linear non-steady state reaction diffusion equations. These equations have been solved using new approach of homotopy perturbation method and analytical solutions pertaining to the concentrations of glucose, oxygen, and gluconic acid are derived...
November 30, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27812737/iafp-ense-an-ensemble-classifier-for-identifying-antifreeze-protein-by-incorporating-grey-model-and-pssm-into-pseaac
#12
Xuan Xiao, Mengjuan Hui, Zi Liu
Antifreeze proteins (AFPs), known as thermal hysteresis proteins, are ice-binding proteins. AFPs have been found in many fields such as in vertebrates, invertebrates, plants, bacteria, and fungi. Although the function of AFPs is common, the sequences and structures of them show a high degree of diversity. AFPs can be adsorbed in ice crystal surface and inhibit the growth of ice crystals in solution. However, the interaction between AFPs and ice crystal is not completely known for human beings. It is vitally significant to propose an automated means as a high-throughput tool to timely identify the AFPs...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27803961/the-effect-of-benzyl-alcohol-on-the-dielectric-structure-of-lipid-bilayers
#13
Hadeel Alobeedallah, Bruce Cornell, Hans Coster
Molecularly tethered lipid bilayer membranes were constructed on a commercially available chemically modified gold substrate. This is a new and promising product that has allowed the construction of very robust lipid bilayers. Very high resolution electrical impedance spectroscopy (EIS) was used to determine the dielectric structure of the lipid bilayers and associated interfaces. The EIS data were modelled in terms of the dielectric substructure using purpose developed software. The hydrophobic region, where the lipid tails are located, was revealed by the EIS in the frequency range of (1-100) Hz and its thickness was calculated from the capacitance of this region and found to be approximately 3-4 nm...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27738716/effects-of-thimerosal-on-lipid-bilayers-and-human-erythrocytes-an-in-vitro-study
#14
Mario Suwalsky, Pablo Zambrano, María José Gallardo, Fernando Villena, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka
Thimerosal (THI, ethyl-mercury thiosalicylate) is added to vaccines as a preservative; as a consequence, infants may have been exposed to bolus doses of Hg that collectively added up to nominally 200 µg Hg during the first 6 months of life. While several studies report an association between THI-containing vaccines and neurological disorders, other studies do not support the causal relation between THI and autism. With the purpose to understand the molecular mechanisms of the toxic effect of THI it was assayed on human red cells and in bilayers built-up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), classes of phospholipids found in the outer and inner monolayers of the human erythrocyte membrane, respectively...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27730256/silk-pva-hybrid-nanofibrous-scaffolds-for-enhanced-primary-human-meniscal-cell-proliferation
#15
Mamatha M Pillai, J Gopinathan, B Indumathi, Y R Manjoosha, K Santosh Sahanand, B K Dinakar Rai, R Selvakumar, Amitava Bhattacharyya
In this study, silk fibroin nanofibrous scaffolds were developed to investigate the attachment and proliferation of primary human meniscal cells. Silk fibroin (SF)-polyvinyl alcohol (PVA) blended electrospun nanofibrous scaffolds with different blend ratios (2:1, 3:1, and 4:1) were prepared. Morphology of the scaffolds was characterized using atomic force microscopy (AFM). The hybrid nanofibrous mats were crosslinked using 25 % (v/v) glutaraldehyde vapor. In degradation study, the crosslinked nanofiber showed slow degradation of 20 % on weight after 35 days of incubation in simulated body fluid (SBF)...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27638176/a-characeae-cells-plasma-membrane-as-a-model-for-selection-of-bioactive-compounds-and-drugs-interaction-of-hamlet-like-complexes-with-ion-channels-of-chara-corallina-cells-plasmalemma
#16
Anatoly Kataev, Olga Zherelova, Valery Grishchenko
Interaction of a HAMLET-like La-OA cytotoxic complex (human α-lactalbumin-oleic acid) and its constituents with the excitable plasmalemma of giant Chara corallina cells was investigated. The voltage-clamp technique was used to study Ca(2+) and Cl(-) transient currents in the plasmalemma of intact cells. The action of the complex and OA on the target cell membrane has a dose-dependent character. It was found that the La-OA complex has an inhibiting effect on Ca(2+) current across the plasmalemma, while α-lactalbumin alone does not affect the electrophysiological characteristics of the cellular membrane...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27619206/lps-induced-macrophage-activation-and-plasma-membrane-fluidity-changes-are-inhibited-under-oxidative-stress
#17
Carlos de la Haba, Antoni Morros, Paz Martínez, José R Palacio
Macrophage activation is essential for a correct and efficient response of innate immunity. During oxidative stress membrane receptors and/or membrane lipid dynamics can be altered, leading to dysfunctional cell responses. Our aim is to analyze membrane fluidity modifications and cell function under oxidative stress in LPS-activated macrophages. Membrane fluidity of individual living THP-1 macrophages was evaluated by the technique two-photon microscopy. LPS-activated macrophage function was determined by TNFα secretion...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27592116/local-anesthetics-affect-gramicidin-a-channels-via-membrane-electrostatic-potentials
#18
Svetlana S Efimova, Anastasiia A Zakharova, Ludmila V Schagina, Olga S Ostroumova
The effects of local anesthetics (LAs), including aminoamides and aminoesters, on the characteristics of single gramicidin A (GA) channels in 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayers were studied. Aminoamides, namely lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), and bupivacaine (BPV), reduced the conductance of GA channels. Aminoesters influenced the current fluctuations induced by GA differently; procaine (PC) did not affect the fluctuations, whereas tetracaine (TTC) distinctly reduced the conductance of single GA channels...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27586664/connexin-hemichannels-methods-for-dye-uptake-and-leakage
#19
REVIEW
Ross G Johnson, Hung C Le, Kristen Evenson, Shelby W Loberg, Tori M Myslajek, Andrea Prabhu, Ann-Marie Manley, Colette O'Shea, Haiying Grunenwald, Madelaine Haddican, Patrick M Fitzgerald, Timothy Robinson, Bruno A Cisterna, Juan C Sáez, Tai-Feng Liu, Dale W Laird, Judson D Sheridan
It is now clear that connexin-based, gap junction "hemichannels" in an undocked state are capable of opening and connecting cytoplasm to the extracellular milieu. Varied studies also suggest that such channel activity plays a vital role in diverse cell processes and abnormal hemichannel activity contributes to pathogenesis. To pursue fundamental questions in this area, investigators require methods for studying hemichannel permeability and dynamics that are quantitative, sensitive, versatile, and available to most cellular and molecular laboratories...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27568391/antioxidant-capacity-of-gallic-acid-in-vitro-assayed-on-human-erythrocytes
#20
Mario Suwalsky, José Colina, María José Gallardo, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Marcela Manrique-Moreno, Benjamín Sepúlveda
Gallic acid (GA) is a polyphenol present in many plants. This study was aimed to investigate the molecular interaction of GA with the human erythrocyte membrane and to determine its antioxidant capacity. The molecular interaction with the membrane of human red cells and the antioxidant property was assayed on both human red cells and molecular models of its membrane. Observations by optical, scanning electron, and defocusing microscopy demonstrated that GA is capable to convert red cells from their normal biconcave shape to crenated echinocytes...
December 2016: Journal of Membrane Biology
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