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American Journal of Cardiology

Berhe W Sahle, Alice J Owen, Lindon M H Wing, Lawrence J Beilin, Mark R Nelson, Garry L R Jennings, Christopher M Reid
Although a high level of alcohol consumption is associated with cardiomyopathy, the benefit or risk of moderate alcohol consumption on incident heart failure (HF) is unknown. This study examined the association between alcohol consumption and risk for HF in older adults with hypertension. The study analyzed data from a cohort of 6,083 participants aged 65 to 84 years at baseline (1995 to 2001) followed for a median of 10.8 years during and after the Second Australian National Blood Pressure Study. Frequency and amount of alcohol consumption were self-reported at baseline and during the clinical trial...
August 11, 2018: American Journal of Cardiology
Nathaniel A Erskine, Barbara Gandek, Hoang V Tran, Hawa Abu, David D McManus, Catarina I Kiefe, Robert J Goldberg
Little is known about how barriers to healthcare access affect health-related quality of life (HRQOL) after an acute coronary syndrome (ACS). In a large cohort of ACS survivors from 6 medical centers in Massachusetts and Georgia enrolled from 2011 to 2013, patients were classified as having any financial barriers, no usual source of care (USOC), or transportation barriers to healthcare based on their questionnaire survey responses. The principal study outcomes included clinically meaningful declines in generic physical and mental HRQOL and in disease-specific HRQOL from 1 to 6 months posthospital discharge...
August 11, 2018: American Journal of Cardiology
André R Durães, Yasmin de S L Bitar, Maria Luiza G Lima, Caroline C Santos, Igor S Schonhofen, José Admirço L Filho, Leonardo Roever
Rivaroxaban has previously been tested in experimental and animal models with encouraging results. We prospectively selected seven patients between May 2017 and January 2018 who underwent isolated mitral valve replacement with a mechanical prosthesis and had unstable INR control at least 3 months after surgery. An intervention of rivaroxaban 15 mg was then administered twice daily for a period of 90 days. No patient presented intracardiac thrombus, reversible ischemic neurological deficit, ischemic or hemorrhagic stroke, and hospitalization or death during 3 months of follow-up...
August 8, 2018: American Journal of Cardiology
Jeroen Vendrik, Martijn S van Mourik, Floortje van Kesteren, Marieke J Henstra, Jan J Piek, Jose P S Henriques, Joanna J Wykrzykowska, Robbert J de Winter, M Marije Vis, Karel T Koch, Jan Baan
No abstract text is available yet for this article.
August 6, 2018: American Journal of Cardiology
Christopher J Broyd, Vasileios Panoulas, Wala Mattar, Mohammed Akhtar, Eliana Shekarchi-Khanghahi, Adam Ioannou, Shahzad G Raja, Mark Mason, Shelley Rahman-Haley, Evangelos Skondras, Miles Dalby, Thomas F Luscher, Tito Kabir
Balloon aortic valvuloplasty has a role in a select group of patients with severe aortic stenosis. Identifying those appropriate patients who will benefit most is key. Given previous evidence demonstrating that histologically the intervention involves a physical disrupting of the cusp's calcium we hypothesized that the quantity of calcium seen at CT will influence outcome. We examined our cohort of patients who had undergone balloon aortic valvuloplasty and CT-quantified aortic valve calcium (AVC) between July 2011 and April 2014...
August 4, 2018: American Journal of Cardiology
Raphae S Barlas, Yoon K Loke, Mamas A Mamas, Joao H Bettencourt-Silva, Isobel Ford, Allan B Clark, Kristian M Bowles, Anthony K Metcalf, John F Potter, Phyo K Myint
The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectively collected data from the Norfolk and Norwich University Hospital Stroke Register. The sample population consisted of 3,572 participants (mean age 74.96 ± 12.67) with ischemic stroke, who were consecutively admitted between 2003 and 2015. Patients were placed on one of three antiplatelet regimens at hospital discharge; aspirin monotherapy, aspirin plus dipyridamole and clopidogrel...
July 30, 2018: American Journal of Cardiology
Amedeo Anselmi, Annamaria Dachille, Vincent Auffret, Majid Harmouche, Antoine Roisne, Marc Bedossa, Hervé Le Breton, Jean-Philippe Verhoye
Minimized length of hospitalization (LoS) and lower risk of hospitalization-related complications are key requirements in the treatment of aortic valve disease, mainly in the elderly candidates. Our objective was to evaluate evolution of LoS after surgical (SAVR) or transcatheter aortic valve implantation (TAVI) and its predictors. We enrolled 1,849 elderly (aged >75) patients receiving SAVR or TAVI from 2009 to 2016. In the surgical cohort (n = 1,006) the mean LoS slightly decreased from 13.81 ± 9.27 days (2009) to 10...
July 20, 2018: American Journal of Cardiology
Gbolahan O Ogunbayo, Richard Charnigo, Yousef Darrat, Jignesh Shah, Ripa Patel, John Suffredini, William Wilson, Kevin Parrott, Nathan Kusterer, Luigi Di Biase, Andrea Natale, Gustavo Morales, Claude S Elayi
Catheter ablation (CA) is an effective treatment for ventricular arrhythmias (VA), with a potential for complications. The presence of structural heart disease (SHD) is associated with a higher complication rate although there is no data comparing CA of VA between patients with SHD and those without. We aimed to compare trends, morbidity, and mortality associated with real world practice of CA for VA (ventricular tachycardia and premature ventricular contraction) based on the presence of SHD. Using weighted sampling in the National Inpatient Sample database, we collected and compared characteristics and outcomes of patients with or without SHD that underwent CA of VA...
July 19, 2018: American Journal of Cardiology
Golnaz Sadjadieh, Thomas Engstrøm, Dan Eik Høfsten, Steffen Helqvist, Lars Køber, Frants Pedersen, Peter Nørkjær Laursen, Hedvig Bille Andersson, Lars Nepper-Christensen, Peter Clemmensen, Rikke Sørensen, Erik Jørgensen, Kari Saunamäki, Hans-Henrik Tilsted, Henning Kelbæk, Lene Holmvang
Most studies reporting bleedings in patients with ST-segment elevation myocardial infarction (STEMI) are reports from clinical trials, which may be unrepresentative of incidences in real-life. In this study, we investigated 1-year bleeding and mortality incidences in an unselected STEMI population, and compared participants with nonparticipants of a randomized all-comer clinical trial (The Third DANish Study of Optimal Acute Treatment of Patients with STEMI (DANAMI-3)). Hospital charts were read and bleedings classified according to thrombolysis in myocardial infarction (TIMI) and Bleeding Academic Research Consortium (BARC) criteria in 2,490 consecutive STEMI patients who underwent primary percutaneous coronary intervention in a single, large, and tertiary heart center...
July 19, 2018: American Journal of Cardiology
Lara C Kovell, Mays T Ali, Allison G Hays, Thomas S Metkus, Jose A Madrazo, Mary C Corretti, Susan A Mayer, Theodore P Abraham, Edward P Shapiro, Monica Mukherjee
Echocardiography is the foundation for diagnostic cardiac testing, allowing for direct identification and management of various conditions. Point-of-care ultrasound (POCUS) has emerged as an invaluable tool for bedside diagnosis and management. The objective of this review is to address the current use and clinical applicability of POCUS to identify, triage, and manage a wide spectrum of cardiac conditions. POCUS can change diagnosis and management decisions of various cardiovascular conditions in a range of settings...
July 19, 2018: American Journal of Cardiology
Maithri Siriwardena, Akshay Bagai, Diego Delgado, Heather J Ross, Evelyn Rozenblyum, Harry Rakowski, Anna Woo, Paaladinesh Thavendiranathan
Hypertrophic cardiomyopathy (HC) is a heterogenous disease with a variable clinical course. Predictors of long-term adverse cardiovascular events are needed. Our objectives were to determine the long-term prognostic value of a single and serial point of care (POC) B-type natriuretic-peptide (BNP) measurements in HC. One hundred and eleven ambulatory patients with HC (mean age 53 ± 16 years) were prospectively recruited over a 2-year period (2004 to 2006). A clinical assessment, comprehensive echocardiogram, and a POC BNP level was obtained at baseline and at a 1- to 2-year follow-up...
July 19, 2018: American Journal of Cardiology
Emre Aslanger, Özlem Yıldırımtürk, Emrah Bozbeyoğlu, Barış Şimşek, Can Yücel Karabay, Ayça Türer Cabbar, Ömer Kozan, Muzaffer Değertekin
Benign variant (BV) ST-segment elevation (STE) is present in anterior chest leads in most individuals and may cause diagnostic confusion in patients presenting with chest pain. Recently, 2 regression formulas were proposed for differentiation of BV-STE from anterior ST-elevation myocardial infarction (MI) on the electrocardiogram, computation of which is heavily device-dependent. We hypothesized that a simpler visual-assessment-based formula, namely (R-wave amplitude in lead V4 + QRS amplitude in V2) - (QT interval in millimeters + STE60 in V3), will be noninferior to these formulas...
July 19, 2018: American Journal of Cardiology
Getu Teressa, Mengru Zhang, Philip Lavenburg, Gregg Cantor, Pamela Noack, Jie Yang, Michael Goyfman, Eric J Feldmann, Javed Butler, Michael Poon
Although the majority of acute chest pain patients are diagnosed with noncardiac chest pain after noninvasive testing, identifying these low-risk patients before testing is challenging. The objective of this study was to validate the coronary artery disease (CAD) consortium models for predicting obstructive CAD and 30-day major adverse cardiovascular events (MACE) in acute chest pain patients considered for coronary computed tomography angiogram, as well as to determine the pretest probability threshold that identifies low-risk patients with <1% MACE...
July 17, 2018: American Journal of Cardiology
Douglas Y Mah, Lynn A Sleeper, Jane E Crosson, Richard J Czosek, Barry A Love, Brian W McCrindle, Laura Muiño-Mosquera, Aaron K Olson, Thomas A Pilcher, Elif Seda Selamet Tierney, Maully J Shah, Stephanie B Wechsler, Luciana T Young, Ronald V Lacro
Patients with the Marfan syndrome (MFS) are at risk for sudden death. The contribution of arrhythmias is unclear. This study examines the prevalence of arrhythmias in children with the MFS and their relation to clinical and/or echocardiographic factors. Data from the Pediatric Heart Network randomized trial of atenolol versus losartan in MFS were analyzed (6 months to 25 years old, aortic root diameter z-score > 3.0, no previous aortic surgery and/or dissection). Baseline 24-hour ambulatory electrocardiographic monitoring was performed...
July 17, 2018: American Journal of Cardiology
Ethan J Rowin, Barry J Maron, Aalap Chokshi, Muhil Kannappan, Knarik Arkun, Wendy Wang, Hassan Rastegar, Martin S Maron
Hypertrophic cardiomyopathy (HC) has historically been characterized as a disease of substantial left ventricular hypertrophy, often associated with dynamic left ventricular outflow tract obstruction. However, we have recently encountered patients with subaortic obstruction and only minimal basal septal thickness, raising important management implications. Thereby, we sought to characterize the natural history and treatment strategies for this under-recognized subgroup of HC patients with dynamic obstruction...
July 17, 2018: American Journal of Cardiology
Maximilian Spieker, Katharina Hellhammer, Jens Spießhöfer, Stratis Katsianos, Jan Balzer, Tobias Zeus, Patrick Horn, Malte Kelm, Ralf Westenfeld
Both pre-existing atrial fibrillation (AF) and mitral valve pressure gradients (MVPG) created by MitraClip implantation have demonstrated predictive power for unfavorable outcomes. Therefore, we aimed to assess the impact of MVPG following MitraClip on outcomes in patients with and without AF. A total of 200 patients who underwent MitraClip implantation in our institution were enrolled. Echocardiography was obtained before and after the procedure. The primary endpoint of the study was all-cause mortality 1-year after MitraClip implantation...
July 17, 2018: American Journal of Cardiology
Hisato Takagi, Yosuke Hari, Norikazu Kawai, Tomo Ando
We performed a meta-analysis of currently available studies assessing prognostic value of psoas-muscle area (PMA) on mortality in patients who underwent transcatheter aortic valve implantation (TAVI). MEDLINE and EMBASE were searched through May 2018 to identify studies reporting ≥1-year all-cause mortality in PMA-stratified TAVI patients. A hazard ratio of follow-up (including early) mortality for "lowest-quantile" versus "higher-quantiles" PMA was extracted from each study. Study-specific estimates were combined in the random-effects model...
July 17, 2018: American Journal of Cardiology
Anna Vachaparampil Mathew, Joyce Yu, Yanhong Guo, Jaeman Byun, Y Eugene Chen, Lu Wang, Mochuan Liu, Robert L Bard, Masako Morishita, Wei Huang, Jianping Li, Jack R Harkema, Sanjay Rajagopalan, Subramaniam Pennathur, Robert D Brook
Fine particulate matter (PM2.5 ) air pollution and environmental temperatures influence cardiovascular morbidity and mortality. Recent evidence suggests that several air pollutants can promote dyslipidemia; however, the impact of ambient PM2.5 and temperature on high-density lipoprotein (HDL) function remains unclear. We hypothesized that daily exposures to higher levels of ambient PM2.5 and colder outdoor temperatures would impair HDL functionality. Lipoproteins, serum cholesterol efflux capacity (CEC), and HDL oxidation markers were measured twice in 50 healthy adults (age 32...
July 10, 2018: American Journal of Cardiology
Eleonora Avenatti, Stephen H Little, Colin M Barker, Sherif F Nagueh
Left atrial (LA) reverse remodeling occurs after transcatheter mitral valve repair, but additional data are needed about changes in LA function. Changes in LA stiffness in patients undergoing MitraClip implantation were evaluated. Baseline, procedural, and 30-day follow-up clinical and imaging data of patients undergoing MitraClip were reviewed. LA operating chamber stiffness was calculated as the ratio of systolic change in LA pressure to LA systolic strain and to stroke volume. Matched preprocedure and postprocedure LA strain analyses were performed in 35 patients, 21 with primary and 14 with functional mitral regurgitation (MR)...
July 5, 2018: American Journal of Cardiology
Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli
Stroke is one of the most feared complications of aortic valve replacement. Although the outcomes of transcatheter aortic valve implantation (TAVI) improved substantially over time, concerns remained about a potentially higher incidence of stroke with TAVI compared with surgical replacement (SAVR). However, comparative data are sparse. We performed a meta-analysis comparing the incidence of stroke among patients undergoing TAVI versus SAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studies and 6 randomized trials) were analyzed...
July 5, 2018: American Journal of Cardiology
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