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American Journal of Cardiology

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https://www.readbyqxmd.com/read/29448977/corrigendum-to-effects-of-rg7652-a-monoclonal-antibody-against-pcsk9-on-low-density-lipoprotein-cholesterol-ldl-c-ldl-c-subfractions-and-inflammatory-biomarkers-in-patients-at-high-risk-of-or-with-established-coronary-heart-disease-from-the-phase-2-equator
#1
Amos Baruch, Sofia Mosesova, John D Davis, Nageshwar Budha, Alexandr Vilimovskij, Robert Kahn, Kun Peng, Kyra J Cowan, Laura Pascasio Harris, Thomas Gelzleichter, Josh Lehrer, John C Davis, Whittemore G Tingley
No abstract text is available yet for this article.
February 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29402421/relation-of-bleeding-events-to-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-treated-by-percutaneous-coronary-intervention-a-danami-3-substudy
#2
Golnaz Sadjadieh, Thomas Engstrøm, Steffen Helqvist, Dan Eik Høfsten, Lars Køber, Frants Pedersen, Peter Nørkjær Laursen, Lars Nepper-Christensen, Peter Clemmensen, Ole Kristian Møller-Helgestad, Rikke Sørensen, Jan Ravkilde, Christian Juhl Terkelsen, Erik Jørgensen, Kari Saunamäki, Hans-Henrik Tilsted, Henning Kelbæk, Lene Holmvang
Bleeding events in relation to treatment of ST-segment elevation myocardial infarction (STEMI) have previously been associated with mortality. In this study, we investigated the incidence and prognosis of, and variables associated with serious bleedings within 30 days after primary percutaneous coronary intervention in patients from The Third Danish Study of Optimal Acute Treatment of Patients with ST-Segment Elevation Myocardial Infarction (DANAMI-3) (n = 2,217). Hospital charts were read within 30 days postadmission to assess bleeding events using thrombolysis in myocardial infarction (TIMI) and Bleeding Academic Research Consortium criteria...
January 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29402419/meta-analysis-of-genotype-guided-versus-standard-dosing-of-vitamin-k-antagonists
#3
REVIEW
Babikir Kheiri, Ahmed Abdalla, Tarek Haykal, Mohammed Osman, Sahar Ahmed, Mustafa Hassan, Ghassan Bachuwa
Vitamin K antagonist (VKA) is a commonly prescribed anticoagulant with a narrow therapeutic window. Genetic polymorphisms account for high VKA dosage variability. Hence, we performed an updated meta-analysis of all randomized clinical trials (RCTs) comparing genotype-guided VKA versus standard dosing algorithms. We conducted a systematic search of electronic databases from inception to October 2017 for all RCTs. The primary outcome was the percentage of time in therapeutic range (TTR). Secondary outcomes were international normalized ratio >4, major and all bleeding events, thromboembolism, adverse and serious adverse events, and all-cause mortality...
January 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29422352/clinical-frailty-as-an-outcome-predictor-after-transcatheter-aortic-valve-implantation
#4
Toby Rogers, M Chadi Alraies, Homam Moussa Pacha, Elizabeth Bond, Kyle D Buchanan, Arie Steinvil, Jiaxiang Gai, Rebecca Torguson, Itsik Ben-Dor, Lowell F Satler, Ron Waksman
Society of Thoracic Surgeons (STS) score and frailty index are calculated routinely as part of transcatheter aortic valve implantation (TAVI) assessment to determine procedure risk. We aim to evaluate the incremental improvement of STS risk score using frailty status in predicting short- and long-term outcome after TAVI. Study population included 544 consecutive TAVI patients who completed full frailty assessment and STS score calculation before the procedure. Frailty is defined by the presence of any 3 of the following 5 criteria: algorithm-defined grip strength and 15-foot walking tests, body mass index < 20 kg/m2, Katz activity of daily living ≤ 4/6, serum albumin < 3...
January 11, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29415808/procedural-outcome-and-midterm-survival-of-lower-risk-transfemoral-transcatheter-aortic-valve-implantation-patients-treated-with-the-sapien-xt-or-sapien-3-device
#5
Jeroen Vendrik, Floortje van Kesteren, Martijn S van Mourik, Jan J Piek, Jan G Tijssen, Jose P S Henriques, Joanna J Wykrzykowska, Rob J de Winter, Antoine H G Driessen, Abdullah Kaya, M Marije Vis, Karel T Koch, Jan Baan
Over the years increasing experience and technical device improvements in transcatheter aortic valve implantation (TAVI) have led to treatment of patients with lower surgical risks. Specifically for this population, device performance and longer term outcome are of great importance. In this single center, we performed a retrospective analysis of 515 consecutive patients with low- to intermediate surgical risk (STS-PROM ≤8), who underwent transfemoral TAVI between January 2009 and February 2017 with the SXT and ES3 prostheses, and we assessed procedural outcome and procedural and 3-year survival...
January 11, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29448978/effect-of-gender-on-unplanned-readmissions-after-percutaneous-coronary-intervention-from-the-nationwide-readmissions-database
#6
Chun Shing Kwok, Jessica Potts, Martha Gulati, Mirvat Alasnag, Muhammad Rashid, Ahmad Shoaib, Muhammad Ayyaz Ul Haq, Rodrigo Bagur, Mamas Andreas Mamas
Women who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared with men, but it is unknown whether gender affects early unplanned rehospitalization. We analyzed 832,753 patients who underwent PCI from 2013 to 2014 in the Nationwide Readmissions Database. We compared gender differences in incidences, predictors, causes, and cost of unplanned 30-day readmissions and examined the effect of co-morbidity. A total of 832,753 men and women who survived the index PCI and were not admitted for a planned readmission were included in the analysis...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397885/relation-of-age-and-health-related-quality-of-life-to-invasive-versus-ischemia-guided-management-of-patients-with-non-st-elevation-myocardial-infarction
#7
Krishna K Patel, Suzanne V Arnold, Philip G Jones, Mohammed Qintar, Karen P Alexander, John A Spertus
In older patients with non-ST-elevation myocardial infarction, an initial invasive strategy reduces cardiovascular events compared with an ischemia-guided approach; however its association with health status outcomes is unknown. Among patients with non-ST-elevation myocardial infarction from 2 multicenter US acute myocardial infarction (AMI) registries, health status was assessed at baseline and at 1, 6, and 12 months after AMI using the Seattle Angina Questionnaire (SAQ) and the 12-item Short-Form Health Survey (SF-12)...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397880/meta-analysis-comparing-frequency-of-overweight-versus-normal-weight-in-patients-with-new-onset-heart-failure
#8
REVIEW
Chayakrit Krittanawong, Anusith Tunhasiriwet, Zhen Wang, HongJu Zhang, Larry J Prokop, Sakkarin Chirapongsathorn, Tao Sun, Takeshi Kitai, W H Wilson Tang
Association between obesity and new-onset heart failure (HF) has repeatedly been established. Less is known about the risk of overweight with the development of HF. The aim of this systematic review and meta-analysis was to explore the association between overweight, obesity, and the incidence of new-onset HF. In this study, we systematically searched MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials from database inception through June 2017...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397106/comparison-of-baseline-characteristics-and-outcomes-in-men-versus-women-with-aortic-stenosis-undergoing-transcatheter-aortic-valve-implantation
#9
Anna Sannino, Molly Szerlip, Katherine Harrington, Gabriele G Schiattarella, Paul A Grayburn
Female gender has been linked to increased risk of adverse events after surgical aortic valve replacement; however, the evidence regarding the role of gender differences on clinical outcomes in patients who underwent transcatheter aortic valve implantation (TAVI) is still debated. This retrospective study included 910 consecutive patients with severe, symptomatic aortic stenosis who underwent TAVI in 2 institutions from January 2012 to July 2016. The primary end point was all-cause mortality at 1 year after TAVI in women versus men...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397104/impact-of-selective-aspiration-thrombectomy-on-mortality-in-patients-with-st-segment-elevation-myocardial-infarction
#10
Istvan Hizoh, Gyongyver Banhegyi, Dominika Domokos, Zalan Gulyas, Laszlo Major, Robert Gabor Kiss
Although routine aspiration thrombectomy (AT) is not recommended by the current American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions guideline, for selected cases, a class IIb indication is given because of lack of data. We studied the impact of selective AT on mortality in patients with ST-segment elevation myocardial infarction using a prospective registry. We analyzed data of 1,255 patients, of whom 535 underwent AT based on operator's decision...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29394999/pharmacologic-treatment-of-patients-with-myocardial-ischemia-with-no-obstructive-coronary-artery-disease
#11
REVIEW
Ricky D Turgeon, Glen J Pearson, Michelle M Graham
Half of women and 1/3 of men with angina and ischemia on stress testing have ischemia with no obstructive coronary artery disease (INOCA). These patients have quality of life (QoL) impairment comparable with patients with obstructive coronary artery disease. Clinicians generally treat INOCA with traditional antianginal agents despite previous studies demonstrating variable response to these medications. We performed a systematic review to evaluate the efficacy and safety of available pharmacologic therapies for INOCA...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29433731/relation-of-increased-epicardial-fat-after-fontan-palliation-to-cardiac-output-and-systemic-ventricular-ejection-fraction
#12
Adam M Lubert, Jimmy C Lu, Albert P Rocchini, Mark D Norris, Sunkyung Yu, Prachi P Agarwal, Maryam Ghadimi Mahani, Adam L Dorfman
Epicardial fat produces multiple proinflammatory cytokines and is associated with adverse cardiovascular events. Inflammation and resultant endothelial dysfunction may play a role in progressive myocardial dysfunction among adults with single ventricle physiology after Fontan palliation, but the potential impact of increased epicardial fat volume (EFV) has not been studied. This study sought to determine if there is greater EFV in Fontan patients compared with a group of repaired tetralogy of Fallot (rTOF) patients...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29428249/computed-tomography-perfusion-aids-in-the-prognostication-of-comatose-postcardiac-arrest-patients
#13
Jai Jai Shiva Shankar, Brandie Stewart-Perrin, Ata-Ur-Rehman Quraishi, Iqbal Bata, Robert Vandorpe
Early assessment of the potential for neurologic recovery in comatose cardiac arrest patients (CCAP) has been a challenge despite significant evolution in management and imaging techniques. The purpose of study was to determine if the use of computed tomography perfusion (CTP) in CCAPs is feasible and if this technique can predict the likelihood that CCAPs will have a devastating outcome at hospital discharge. We prospectively enrolled 10 newly admitted comatose adults who had an out-of-hospital cardiac arrest and were treated with standard therapeutic hypothermia protocols...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397881/incidence-predictors-and-impact-on-six-month-mortality-of-three-different-definitions-of-contrast-induced-acute-kidney-injury-after-coronary-angiography
#14
Benoit Guillon, Fiona Ecarnot, Charles Marcucci, Didier Ducloux, Marion Chatot, Marc Badoz, Benjamin Bonnet, Romain Chopard, Pierre Frey, Nicolas Meneveau, François Schiele
We assessed incidence, predictors, and impact on 6-month mortality of contrast-induced acute kidney injury (CI-AKI) after coronary angiography with or without percutaneous coronary intervention in patients with acute coronary syndrome (ACS), according to 3 different CI-AKI definitions. Serum creatinine (sCr) was assessed at baseline and 48 to 72 hours after procedure to classify patients into 3 CI-AKI groups: Group 1: increase in sCR ≥25% over baseline but absolute increase <0.5 mg/dl; Group 2: absolute increase ≥0...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397105/effect-of-electrophysiology-assessment-on-mortality-and-hospitalizations-in-patients-with-new-onset-atrial-fibrillation
#15
Sheldon M Singh, Lauren Webster, Feng Qiu, Peter C Austin, Dennis T Ko, Jack V Tu, Harindra C Wijeysundera
Few patients with atrial fibrillation (AF) receive care by cardiac electrophysiologists. Although previous work has highlighted differential care for patients with AF treated by electrophysiologists, it is unclear whether this is associated with improved clinical outcomes. This retrospective population-level propensity score-matched cohort study included patients aged 20 to 80 years with new-onset AF presenting to an emergency department (ED) in Ontario, Canada, between 2010 and 2012. Patients were followed until March 31, 2015...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29395001/effect-of-antiplatelet-therapy-on-cardiac-outcomes-in-patients-with-acute-coronary-syndrome
#16
LETTER
Zulkif Tanriverdi, Feyzullah Besli, Fatih Gungoren, İbrahim Halil Altiparmak
No abstract text is available yet for this article.
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29329826/gender-differences-in-presentation-treatment-and-in-hospital-outcome-of-patients-admitted-with-heart-failure-complicated-by-atrial-fibrillation-from-the-get-with-the-guidelines-heart-failure-gwtg-hf-registry
#17
Mitra Daneshvar, Nayan Desai, John Andriulli, Matthew Ortman, Eben Eno, Krystal Hunter, Andrea M Russo
Almost 25% of patients with heart failure (HF) have coexisting atrial fibrillation (AF), the latter of which may increase morbidity and mortality. Despite the high prevalence of HF with concomitant AF, this subgroup of patients remains understudied. This study examines gender differences in presentation, treatment and in-hospital outcome of patients with HF and AF. The Get With the Guidelines-Heart Failure (GWTG-HF) database enrolled 6,496 patients with HF who presented to Cooper University Hospital from 2005 to 2012...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29402420/effect-of-optimization-of-medical-treatment-on-long-term-survival-of-patients-with-heart-failure-after-implantable-cardioverter-defibrillator-and-cardiac-resynchronization-device-implantation-from-the-french-national-egb-database
#18
Grégoire Massoullié, Chenaf Chouki, Aurélien Mulliez, Patrick Rossignol, Sylvain Ploux, Bruno Pereira, Adrien Reuillard, Fréderic Jean, Marius Andronache, Alain Eschalier, Pascal Motreff, Guillaume Clerfond, Pierre Bordachar, Nicolas Authier, Romain Eschalier
Prognosis of heart failure with reduced ejection fraction (HFrEF) is improved by drug optimization according to guidelines; however, little is known regarding such optimization in HFrEF patients with an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT). This study aimed to describe implementation of this optimized strategy and its impact in patients implanted with an ICD/CRT. Using a 1/97th representative sample of the French national health-care insurance system claims database, a retrospective cohort study was conducted including HFrEF patients implanted with ICD or CRT between January 2009 and December 2014...
January 3, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29402422/comparison-of-outcomes-and-costs-associated-with-aspirin%C3%A2-%C3%A2-%C3%A2-clopidogrel-after-coronary-artery-bypass-grafting
#19
Ramin Ebrahimi, Sandeep Gupta, Brendan M Carr, Muath Bishawi, Faisal G Bakaeen, G Hossein Almassi, Joseph Collins, Frederick L Grover, Jacquelyn A Quin, Todd H Wagner, A Laurie W Shroyer, Brack Hattler
Optimal antiplatelet therapy after coronary artery bypass graft (CABG) surgery remains controversial. This study evaluated the role of dual antiplatelet therapy using aspirin and clopidogrel (DAPT) versus antiplatelet therapy using aspirin only (ASA) on post-CABG clinical outcomes and costs. In the Department of Veterans Affairs Randomized On/Off Bypass (ROOBY) trial, clopidogrel use after CABG was prospectively collected beginning in year 2 of this study to include 1,525 of the 2,203 original ROOBY patients who received aspirin after CABG...
January 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29402418/description-of-a-method-to-obtain-complete-one-year-follow-up-in-the-society-of-thoracic-surgeons-american-college-of-cardiology-transcatheter-valve-therapy-registry
#20
Jordan Wooley, Holly Neatherlin, Cecile Mahoney, John J Squiers, Deborah Tabachnick, Mitta Suresh, Eleanor Huff, Sukhdeep S Basra, J Michael DiMaio, David L Brown, Michael J Mack, Elizabeth M Holper
The Centers for Medicare and Medicaid Services National Coverage Determination requires centers performing transcatheter aortic valve implantation (TAVI) to report clinical outcomes up to 1 year. Many sites encounter challenges in obtaining complete 1-year follow-up. We report our process to address this challenge. A multidisciplinary process involving clinical personnel, data and quality managers, and research coordinators was initiated to collect TAVI data at baseline, 30 days, and 1 year. This process included (1) planned clinical follow-up of all patients at 30 days and 1 year; (2) query of health-care system-wide integrated data warehouse (IDW) to ascertain last date of clinical contact within the system for all patients; (3) online obituary search, cross-referencing for unique patient identifiers to determine if mortality occurred in remaining unknown patients; and (4) phone calls to remaining unknown patients or patients' families...
January 2, 2018: American Journal of Cardiology
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