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American Journal of Cardiology

Anat Berkovitch, Arwa Younis, Yoni Grossman, Shlomo Segev, Shaye Kivity, Yechezkel Sidi, Roy Beinart, Ilan Goldenberg, Elad Maor
Clinical and experimental data support a critical role for inflammation in cardiovascular disease. The purpose of the current study was to examine the relation between an inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and incident atrial fibrillation (AF) in asymptomatic adults. We investigated 21,118 self-referred men and women who were annually screened in a tertiary medical center. All subjects were free of AF at baseline and had their serum NLR calculated at the first annual visit. Subjects were divided into 2 groups based on their baseline NLR: Low (<2...
November 7, 2018: American Journal of Cardiology
Aakash Bavishi, Travis Howard, Jooho P Kim, Brent Hiramoto, Jacob B Pierce, Parrykumar Mendapara, Jonathan Alhalel, Han-Wei Wu, Nina Srdanovich, Neil J Stone
Previous studies assessing healthcare provider compliance to the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines indicate a significant underuse of statin therapy at appropriate intensity. However, data are limited in primary prevention patients. Our study aimed to evaluate the impact of the 2013 ACC/AHA guidelines through a retrospective analysis of primary prevention patients presenting with first time acute coronary syndrome (ACS). We retrospectively calculated the 10-year predicted Atherosclerotic Cardiovascular Disease (10yASCVD) risk in 1,265 patients ages 40 to 75 who presented with ACS and no previous ASCVD...
November 7, 2018: American Journal of Cardiology
Haqeel A Jamil, Sajeel A Mohammed, John Gierula, Maria F Paton, Judith E Lowry, Richard M Cubbon, Mark T Kearney, Klaus K A Witte
Symptomatic sustained ventricular tachycardia is a life threatening arrhythmia requiring prompt treatment. However, the risk associated with asymptomatic nonsustained ventricular tachycardia (NSVT) detected on routine permanent pacemaker (PPM) interrogation in patients with known cardiac conduction disease is unknown. Our aim is to determine if asymptomatic NSVT detected on PPM interrogation is associated with increased mortality. As part of a prospective observational cohort study, 582 patients with long-term pacemakers were recruited at a tertiary cardiac centre, and followed for 4 ± 1...
November 7, 2018: American Journal of Cardiology
Jonathon P Fanning, Louise E See Hoe, Margaret R Passmore, Adrian G Barnett, Nchafatso G Obonyo, Jonathan E Millar, Allan J Wesley, Jacky Y Suen, John F Fraser
Magnetic resonance imaging (MRI) studies have consistently identified a high incidence of silent brain infarction (SBI) after cardiac intervention. The frequent occurrence, objective measurement and clinical sequelae of SBI have seen interest in their detection for both research and clinical purposes. However, MRI is expensive, time-consuming, unsafe in acutely-ill patients, and not always available, limiting its use as a routine screening tool. For this purpose, a blood biomarker of SBI would be the "Holy Grail...
November 6, 2018: American Journal of Cardiology
Christina Ronai, Sunil J Ghelani, Audrey C Marshall, David M Harrild, Kimberlee Gauvreau, Steven D Colan, David W Brown
Transient left ventricular (LV) dysfunction occurs in some infants born with critical pulmonary stenosis (PS) or membranous pulmonary atresia with intact ventricular septum (PAIVS) after pulmonary valve (PV) balloon dilation (BD). The cause for this is not well understood. We sought to characterize this LV dysfunction by investigating regional differences in this cohort using myocardial strain imaging. Patients who underwent neonatal (<2 weeks age) PV BD for critical PS or PAIVS from Jan, 2007 to March, 2014 with echocardiographic images suitable for strain analysis were identified; infants with ≥moderate post-BD LV dysfunction (ejection fraction <40%, n = 8) were matched 1:1 with controls who underwent PV BD but did not develop LV dysfunction...
November 6, 2018: American Journal of Cardiology
James McKinney, Jane Velghe, Johanna Fee, Saul Isserow, Jonathan A Drezner
Current definitions of an athlete range from loosely defined to overly restrictive, rely on qualitative subjective descriptors, and fail to capture the majority of physically active patients. To improve the understanding between exercise and health metrics a more standardized and granular classification of exercising patients is required. We propose a simplified algorithm to categorize and define exercising patients based on the: (1) intent of exercise, (2) volume of exercise (hours/week), and (3) level of competition...
November 6, 2018: American Journal of Cardiology
Jian Liang Tan, Hee Kong Fong, Edo Y Birati, Yuchi Han
Clinical and subclinical cardiac sarcoidosis (CS) remains diagnostically challenging as the sensitivity and specificity of the diagnostic modalities are limited. The Japanese Ministry of Health and Welfare criteria and the Heart Rhythm Society expert consensus statement on CS are the most common guidelines used to diagnose CS. However, they are mostly based on expert opinions and lack clinical trial validation. The emergence and increase use of newer imaging modalities such as cardiac magnetic resonance and positron emission tomography may give valuable information for accurate diagnosis and assessment of treatment response in CS patient...
November 6, 2018: American Journal of Cardiology
Justin McNair Canada, Antonio Abbate, Rebecca Collen, Hayley Billingsley, Leo Francis Buckley, Salvatore Carbone, Cory Ross Trankle, Michael Ola Idowu, Dinesh Kadariya, Benjamin Van Tassell, Arun Jayant Sanyal, Mohammad Shadab Siddiqui
The purpose of this study was to determine the relation between liver histology, exercise tolerance, and diastolic function in patients with nonalcoholic fatty liver disease (NAFLD). Myocardial remodeling and diastolic dysfunction have been associated with NAFLD. However, its physiological impact and relationship to the histological severity of NAFLD is not known. Cardiopulmonary exercise testing and stress echocardiography was performed in subjects with biopsy-confirmed NAFLD. Maximal aerobic exercise capacity (peak oxygen consumption [VO2 ]) was related to diastolic function (mitral annulus Doppler velocity e' and ratio of early diastolic filling pressure [E] to e' [E/e']) at rest and peak exercise...
November 6, 2018: American Journal of Cardiology
Serge Korjian, Yazan Daaboul, François Laliberté, Qi Zhao, Roxana Mehran, Christoph Bode, Jonathan Halperin, Freek W A Verheugt, Gregory Y H Lip, Marc Cohen, Eric D Peterson, Keith A A Fox, C Michael Gibson, Duane S Pinto
The PIONEER AF-PCI trial demonstrated that in atrial fibrillation patients who underwent intracoronary stenting, either rivaroxaban 15 mg daily plus P2Y12 inhibitor monotherapy (Group 1) or 2.5 mg rivaroxaban twice daily plus dual antiplatelet therapy (DAPT) (Group 2) was associated with fewer recurrent hospitalizations, primarily for bleeding and cardiovascular events, compared with standard-of-care vitamin K antagonist and DAPT (Group 3). Associated costs are unknown. This study estimates costs associated with rivaroxaban strategies compared with vitamin K antagonist and DAPT...
November 6, 2018: American Journal of Cardiology
Jorge Nuche, José-Manuel Montero Cabezas, Carmen Jiménez López-Guarch, Maite Velázquez Martín, Sergio Alonso Charterina, Yolanda Revilla Ostolaza, Fernando Arribas Ynsaurriaga, Pilar Escribano Subías
Detection of pulmonary artery aneurysms (PAA) in pulmonary arterial hypertension (PAH) is increasing. We sought to determine the frequency of PAA in a PAH cohort, variables related to its development and its prognostic impact. We conducted a retrospective analysis of PAH patients who underwent a computed tomography or magnetic resonance. PAA was defined as a pulmonary artery >40 mm. Baseline, echocardiographic, and hemodynamic findings at PAH diagnosis were compared. Freedom from death or lung transplant was estimated by Kaplan-Meier method and compared by log-rank test...
November 6, 2018: American Journal of Cardiology
Yosuke Negishi, Akihito Tanaka, Hideki Ishii, Kensuke Takagi, Yosuke Inoue, Yusuke Uemura, Norio Umemoto, Naoyuki Yoshioka, Itsuro Morishima, Hiroshi Asano, Masato Watarai, Naoki Shibata, Susumu Suzuki, Toyoaki Murohara
The incidence of contrast-induced nephropathy (CIN) increases with the progression of renal dysfunction. Recent reports have shown that percutaneous coronary intervention (PCI) can be safely performed even in patients with advanced renal dysfunction by appropriate CIN-prevention strategies. However, data are limited regarding the occurrence and prognostic influence of CIN in patients with advanced renal dysfunction. We examined the data obtained from 323 consecutive patients with advanced renal dysfunction (eGFR <30 ml/min/1...
November 6, 2018: American Journal of Cardiology
Jennifer Mancio, Diana Azevedo, Mariana Fragao-Marques, Ines Falcao-Pires, Adelino Leite-Moreira, Nuno Lunet, Ricardo Fontes-Carvalho, Nuno Bettencourt
Many studies have explored the hypothesis that epicardial adipose tissue (EAT) accumulation adversely affects cardiac remodeling. We assessed, through a systematic review and meta-analysis, whether EAT is linked to left atrial (LA) and left ventricular (LV) structure and function, irrespective of global or abdominal visceral adiposity. We searched MEDLINE, Scopus, and Web of Science for studies evaluating the association of EAT volume quantified by computed tomography with cardiac morphology and function. We used DerSimonian and Laird random-effects models to summarize the adjusted-effect of 10 ml variation of EAT on LA size, LV mass, LV diastolic and systolic functions parameters, and presence of diastolic dysfunction...
November 6, 2018: American Journal of Cardiology
Claire Bouleti, Martin Flamant, Brigitte Escoubet, Florence Arnoult, Olivier Milleron, Emmanuelle Vidal-Petiot, Maud Langeois, Phalla Ou, François Vrtovsnik, Guillaume Jondeau
In recent years, simple renal cysts have been associated with an increased risk of aortic aneurysms. There is little data regarding aortic dilation in patients with autosomal dominant polycystic kidney disease (ADPKD). The aim of this study was to compare Sinuses of Valsalva (SoV) and tubular ascending aorta diameters in ADPKD patients with matched controls. From 2008 to 2016, 61 consecutive ADPKD patients who had an echocardiogram performed in our institution were matched 1:1 with controls for sex, age, blood pressure, and β-blocker therapy use...
November 6, 2018: American Journal of Cardiology
Muthiah Vaduganathan, William B White, David M Charytan, David A Morrow, Yuyin Liu, Faiez Zannad, Christopher P Cannon, George L Bakris
A deeper understanding of the interplay between the renal axis and cardiovascular (CV) disease is needed in type 2 diabetes mellitus (T2DM). We aimed to explore the prognostic value of a comprehensive panel of renal biomarkers in patients with T2DM at high CV risk. We evaluated the prognostic performance of both serum (Cystatin C) and urine renal biomarkers (neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 protein, and indices of urinary protein excretion) in 5,380 patients with T2DM and recent acute coronary syndromes in the EXAMINE trial...
November 6, 2018: American Journal of Cardiology
Rami Doukky, Gabriel Improvola, Michael J Shih, Briana T Costello, Juan M Munoz-Pena, Yasmeen Golzar, Bosko Margeta, Charlotte J Bai
Although echocardiography is usually diagnostic of cardiac tamponade, it may not be readily available at the point-of-care. We sought to develop and validate a measurement of respirophasic variation in the amplitude of pulse oximetry plethysmographic waveforms as a diagnostic tool for cardiac tamponade. Pulse oximetry plethysmographic waveforms were recorded, and the ratio of maximum-to-minimum measured amplitude of these waveforms from one respiratory cycle was calculated by blinded observers. Ratios from 3 consecutive respiratory cycles were then averaged to derive an "oximetry paradoxus" ratio...
November 6, 2018: American Journal of Cardiology
Aleksandr Voskoboinik, Benedict T Costello, Andre La Gerche, Sandeep Prabhu, Geoff Wong, Michael D Flannery, Chrishan Nalliah, Hariharan Sugumar, Fabian Springer, Jonathan M Kalman, Andrew J Taylor, Peter M Kistler
Light-to-moderate regular alcohol consumption has been associated with reduced mortality, heart failure, and sudden death, with a well described "U-shaped" relationship. We sought to determine whether markers of diffuse ventricular fibrosis as assessed by cardiac magnetic resonance imaging (CMR) T1 mapping differ between nondrinkers and regular drinkers. We prospectively recruited 165 participants to undergo 3T CMR ventricular T1 mapping which included 120 regular light-to-moderate drinkers (7 to 28 standard drinks per week for >12 months) and 45 age and gender-matched nondrinking controls (1 standard drink ∼12 g alcohol)...
November 6, 2018: American Journal of Cardiology
Jifu Jin, Su Chi Chang, Bo Shen, Jiarui Xu, Wuhua Jiang, Yimei Wang, Yamin Zhuang, Chunsheng Wang, Jie Teng, Xiaoqiang Ding
High estimated pulmonary artery systolic pressure (ePASP) has been established as a detrimental predictor for adverse outcomes in patients with chronic kidney disease. However, the relation between preoperative high ePASP and the development of cardiac surgery associated acute kidney injury (CSA-AKI) has not been validated. We performed a retrospective cohort study of adult patients who underwent valve surgery in 2015 at Zhongshan Hospital, Fudan University. Right ventricular systolic pressure, a surrogate for pulmonary systolic pressure, was estimated in the study group of 1056 patients by preoperative echocardiography...
November 6, 2018: American Journal of Cardiology
Saraschandra Vallabhajosyula, Shilpkumar Arora, Ankit Sakhuja, Sopan Lahewala, Varun Kumar, Ghanshyam P S Shantha, Alexander C Egbe, John M Stulak, Bernard J Gersh, Rajiv Gulati, Charanjit S Rihal, Abhiram Prasad, Abhishek J Deshmukh
Postcardiac surgery cardiogenic shock (PCCS) is seen in 2% to 6% of patients who undergo cardiac surgery. There are limited large-scale data on the use of mechanical circulatory support (MCS) in these patients. This study sought to evaluate the in-hospital mortality, trends, and resource utilization for PCCS admissions with and without MCS. A retrospective cohort of PCCS between 2005 and 2014 with and without the use of temporary MCS was identified from the National Inpatient Sample. Admissions for permanent MCS and heart transplant were excluded...
November 6, 2018: American Journal of Cardiology
Joon Chul Jung, Myoung-Jin Jang, Ho Young Hwang
Although current guidelines recommend mitral valve repair (MVr) over mitral valve replacement (MVR) for patients with mitral regurgitation (MR), it is unclear if it should be also recommended in elderly patients with limited life expectancy. This study was conducted to compare the results of MVr with those of MVR to determine the optimal treatment option for patients with degenerative MR, particularly according to the patient's age. A literature search of 5 electronic databases was performed. The primary outcome was all-cause mortality...
November 6, 2018: American Journal of Cardiology
Kamleshun Ramphul, Stephanie G Mejias, Jyotsnav Joynauth
No abstract text is available yet for this article.
November 2, 2018: American Journal of Cardiology
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