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Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme

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https://www.readbyqxmd.com/read/30453336/correction-intervention-strategies-into-glycoprotein-hormone-receptors-for-modulating-mal-function-with-special-emphasis-on-the-tsh-receptor
#1
Gerd Krause, Patrick Marcinkowski
No abstract text is available yet for this article.
November 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30408832/serum-vitamin-d-binding-protein-level-associated-with-metabolic-cardiovascular-risk-factors-in-women-with-the-polycystic-ovary-syndrome
#2
Justyna Kuliczkowska-Plaksej, Renato Pasquali, Andrzej Milewicz, Felicja Lwow, Diana Jedrzejuk, Marek Bolanowski
The objective of the study was to measure the levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) and assess their relationships with cardiovascular risk factors in women with the polycystic ovary syndrome (PCOS). A group of 267 women, aged 20-35 years (24.7 ± 4.9): 167 with PCOS and 100 healthy women were divided according to body mass index. Biochemical and hormonal parameters were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA...
November 8, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30406628/metabolic-syndrome-as-a-predictor-of-adrenal-functional-status-a-discriminant-multivariate-analysis-versus-logistic-regression-analysis
#3
Charalampos Tsentidis, Andreas Bampilis, Vasiliki Ntova, Dimitrios Fragkos, Christos Panos, Christina Limniati, Georgia Kassi
Patients harboring adrenal tumors are characterized by higher prevalence of metabolic syndrome (MetS) components and a higher incidence of cardiovascular complications, especially in cases of subclinical or overt hormonal hypersecretion. Early detection and referral of those patients in tertiary centers could prevent unfavorable outcomes. In this cross-sectional, retrospective study, we evaluated 111 consecutive patients with adrenal incidentalomas and 14 patients with known hypersecretory adrenal lesions (autonomous cortisol secretion, primary aldosteronism, and pheochromocytoma), who were investigated in our clinic...
November 7, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30396220/central-tolerance-mechanisms-to-tshr-in-graves-disease-contributions-to-understand-the-genetic-association
#4
Ricardo Pujol-Borrell, Daniel Álvarez-Sierra, Dolores Jaraquemada, Ana Marín-Sánchez, Roger Colobran
In the last 3 years, the association of thyrotropin receptor gene (TSHR) variations to Graves' disease (GD) has been confirmed. It is now well established that a 30 Kb region of intron 1 of the TSHR gene is linked to GD predisposition. Elucidating the mechanism(s) by which these polymorphisms confer susceptibility is difficult but would constitute an important advance in endocrine autoimmunity in general. Two hypotheses, both postulating TSHR gene regulatory mechanisms, are discussed. One postulates differential level of expression in the thymus, involving central tolerance...
November 5, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30396219/braf-v600e-and-retinoic-acid-in-radioiodine-refractory-papillary-thyroid-cancer
#5
Jan Benedikt Groener, Debora Gelen, Carolin Mogler, Esther Herpel, Csaba Toth, Zoltan Kender, Marco Peichl, Sabine Haufe, Uwe Haberkorn, Alba Sulaj, Johanna Zemva, Stefan Kopf, Peter Paul Nawroth, Maik Brune, Gottfried Rudofsky
Radioiodine refractoriness in differentiated thyroid cancer remains an unsolved therapeutic problem. Response to retinoids might depend on specific genetic markers. In this retrospective analysis, associations between BRAF V600E and clinical outcomes after redifferentiation with retinoic acid (RA) and radioiodine therapy (RIT) were investigated. Thirteen patients with radioiodine-refractory (RAI-R) papillary thyroid cancer (PTC) were treated with 13-cis-RA followed by iodine-131 treatment at the Department of Endocrinology, Heidelberg University Hospital, Heidelberg, Germany...
November 5, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30366347/intervention-strategies-into-glycoprotein-hormone-receptors-for-modulating-mal-function-with-special-emphasis-on-the-tsh-receptor
#6
Gerd Krause, Patrick Marcinkowski
The thyrotropin receptor (TSHR), the lutropin- (LHR), and the follicotropin receptor (FSHR) belong to glycoprotein hormone receptors (GPHR), a subgroup of the class A G-protein coupled receptors. In this review, the unique features of GPHR have been taken into account for their pharmacological interventions: i) The respective hormone and stimulating or blocking antibodies are binding on the large ectodomain that is ii) via a hinge region, containing iii) an internal tethered agonist linked to the transmembrane domain...
October 26, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30360003/thyroid-peroxidase-as-an-autoantigen-in-hashimoto-s-disease-structure-function-and-antigenicity
#7
Daniel E Williams, Sarah N Le, Marlena Godlewska, David E Hoke, Ashley M Buckle
Human thyroid peroxidase (TPO), is an important enzyme responsible for the biosynthesis of thyroid hormones and is a major autoantigen in autoimmune thyroid diseases (AITDs) such as the destructive Hashimoto's thyroiditis. Although the structure of TPO has yet to be determined, its extracellular domain consists of three regions that exhibit a high degree of sequence similarity to domains of known three-dimensional structure: the myeloperoxidase (MPO)-like domain, complement control protein (CCP)-like domain, and epidermal growth factor (EGF)-like domain...
October 25, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30357776/reflections-on-thyroid-autoimmunity-a-personal-overview-from-the-past-into-the-future
#8
Basil Rapoport, Sandra M McLachlan
After investigating thyroid autoimmunity for more than 40 years, we present a personal perspective on the field. Despite effective therapies for Graves' hyperthyroidism and Hashimoto's thyroiditis, cures are elusive. Novel forms of therapy are being developed, such as small molecule inhibitors of the TSH receptor (TSHR), but cure will require immunotherapy. This goal requires advances in understanding the pathogenesis of thyroid autoimmunity, the 'keys' for which are the thyroid antigens themselves. Presently, however, greater investigative focus is on non-thyroid specific immune cell types and molecules...
October 24, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30340234/the-relationship-between-bone-mineral-density-and-type-2-diabetes-in-obese-children-and-adolescents-at-the-time-of-initial-diagnosis
#9
Hae Sang Lee, Jong Seo Yoon, Kyu Jung Park, Jung Sub Lim, Jin Soon Hwang
Long-term effects of type 2 diabetes mellitus (T2D) on bone health remain unclear. The objective of this study was to assess the possible association of bone mineral density (BMD) at multiple sites with T2D after correcting for several potential confounders such as age, sex, Tanner stage, and BMI known to affect BMD in adolescents with newly developed T2D. In this cross-sectional study, 17 children and adolescents with T2D and 59 age, sex, and BMI-matched controls were included. All subjects underwent dual-energy X-ray absorptiometry to measure regional and whole-body composition with Lunar Prodigy at the time of initial diagnosis...
October 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30286486/current-and-future-treatments-for-graves-disease-and-graves-ophthalmopathy
#10
Anupam Kotwal, Marius Stan
The course and pathogenesis of Graves' disease and Graves' ophthalmopathy are interdependent, influencing each other's therapeutic choices. Multiple factors including geographic location, access to medical services, patient and physician preferences influence the management of these conditions. Graves' disease is classically managed with one of three treatment options - antithyroid drugs, radioactive iodine, and thyroidectomy. In recent years, there has been a shift towards antithyroid drugs, including long term therapy with these agents, given the advantage of avoiding hypothyroidism and the apparent safety of this approach...
October 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30286485/thyrotropin-receptor-blocking-antibodies
#11
Tanja Diana, Paul D Olivo, George J Kahaly
Autoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) may mimic or block the action of TSH or be functionally neutral. Measurement of anti-TSHR-Ab can be done either via competitive-binding immunoassays or with functional cell-based bioassays. Antibody-binding assays do not assess anti-TSHR-Ab functionality, but rather measure the concentration of total anti-TSHR binding activity. In contrast, functional cell-based bioassays indicate whether anti-TSHR-Ab have stimulatory or blocking activity...
October 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30286483/the-effect-of-magnesium-and-vitamin-e-co-supplementation-on-glycemic-control-and-markers-of-cardio-metabolic-risk-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#12
Mehri Jamilian, Niloufar Kazemi Sabzevar, Zatollah Asemi
Data on the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk of patients with polycystic ovary syndrome (PCOS) were collected. This investigation was conducted to evaluate the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. This randomized, double-blind, placebo-controlled trial was carried out on 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to receive 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n=30 each group) for 12 weeks...
October 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30273935/the-3pas-an-update-on-the-association-of-pheochromocytomas-paragangliomas-and-pituitary-tumors
#13
Paraskevi Xekouki, Ana Brennand, Ben Whitelaw, Karel Pacak, Constantine A Stratakis
Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PHEO/PGL) are rare tumors. Although they may co-exist by coincidence, there is mounting evidence that genes predisposing in PHEO/PGL development, may play a role in pituitary tumorigenesis. In 2012, we described a GH-secreting PA caused by an SDHD mutation in a patient with familial PGLs and found loss of heterozygosity at the SDHD locus in the pituitary tumor, along with increased hypoxia-inducible factor 1α (HIF-1α) levels. Additional patients with PAs and SDHx defects have since been reported...
October 1, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30273934/noninvasive-liver-fibrosis-tests-in-patients-with-nonalcoholic-fatty-liver-disease-an-external-validation-cohort
#14
Stergios A Polyzos, Aristidis Slavakis, Georgios Koumerkeridis, Panagiotis Katsinelos, Jannis Kountouras
The main aim of this study was the comparative evaluation of nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS), fibrosis 4 index (FIB-4), AST-to-Platelet Ratio Index (APRI), and enhanced liver fibrosis (ELF) test in distinguishing none/early (F0/F1) from significant/advanced (F2/F3) fibrosis in NAFLD patients, thereby providing an external validation cohort. Thirty-one patients with biopsy-proven NAFLD and 10 matched controls without NAFLD were prospectively enrolled. Serum hyaluronic acid (HA), aminoterminal propeptide of type III procollagen (PIIINP), tissue inhibitor of metallo-proteinases (TIMP)-1, and biochemical tests were measured...
October 1, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30227459/catecholamine-induced-cardiomyopathy-in-pheochromocytoma-how-to-manage-a-rare-complication-in-a-rare-disease
#15
Jenn Rachelle U Santos, Alessandra Brofferio, Bruna Viana, Karel Pacak
Pheochromocytomas and paragangliomas (PHEOs) are rare neuroendocrine tumors. Clinical manifestations include different cardiovascular signs and symptoms, which are related to excessive secretion of catecholamines. Catecholamine-induced cardiomyopathy in PHEO (CICMPP) is a rare but dreaded complication of PHEO. Once patient is diagnosed with this condition, the prognosis is worse and a surgical risk is much higher than expected. This article focuses on how catecholamines affect the heart and the pathophysiologic mechanism of CICMPP...
September 18, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30142639/an-update-on-the-histology-of-pheochromocytomas-how-does-it-relate-to-genetics
#16
Lindsey Oudijk, José Gaal, Karen Koopman, Ronald R de Krijger
Pheochromocytomas are rare neuroendocrine tumors of the adrenal gland, whereas any extra-adrenal tumor with similar histology is designated as paraganglioma. These tumors have a very high rate of germline mutations in a large number of genes, up to 35% to 40%, frequently predisposing for other tumors as well. Therefore, they represent a phenomenal challenge for treating physicians. This review focuses on pheochromocytomas only, with special attention to gross and microscopic clues to the diagnosis of genetic syndromes, including the role of succinate dehydrogenase subunit A and subunit B immunohistochemistry as surrogate markers for genetic analysis in the field of succinate dehydrogenase subunit gene mutations...
August 24, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30452070/correction-the-effects-of-melatonin-supplementation-on-glycemic-control-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Amin Doosti-Irani, Vahidreza Ostadmohammadi, Naghmeh Mirhosseini, Mohammad Ali Mansournia, Russel J Reiter, Maryam Kashanian, Maryam Rahimi, Maryamalsadat Razavi, Zatollah Asemi
No abstract text is available yet for this article.
November 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30396211/levothyroxine-therapy-achieves-physiological-ft3-ft4-ratios-at-higher-than-normal-tsh-levels-a-novel-justification-for-t3-supplementation
#18
David Strich, Cherut Chay, Gilad Karavani, Shalom Edri, David Gillis
In euthyroidism, as thyroid Stimulating hormone (TSH) levels increase, the free triiodothyronine (FT3) to free thyroxine (FT4) ratio increases. The aim of this study was to assess if beyond the euthyroid range of TSH levels FT3/FT4 ratio continues to increase and if levothyroxine treatment reduces this ratio, possibly through TSH suppression. This cross sectional retrospective study included a total of 77 832 patients [age 22.76±15.17 years (4 days to 112 years)] evaluated and treated in community clinics between January 2009 and September 2013...
November 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30396210/association-between-plasma-concentration-of-klotho-protein-osteocalcin-leptin-adiponectin-and-bone-mineral-density-in-patients-with-chronic-kidney-disease
#19
Małgorzata Marchelek-Mysliwiec, Magda Wisniewska, Monika Nowosiad-Magda, Krzysztof Safranow, Ewa Kwiatkowska, Bolesław Banach, Barbara Dołegowska, Katarzyna Dołegowska, Joanna Stepniewska, Leszek Domanski, Andrzej Pawlik, Kazimierz Ciechanowski
Patients with early-stage chronic kidney disease (CKD) are susceptible to changes in metabolic processes. Partial loss of kidney function leads to homoeostatic disturbances in bone and fatty tissue. The aim of this study was to investigate the association between plasma concentrations of Klotho protein, FGF23, leptin, adiponectin, osteocalcin, and bone mineral density (BMD) in patients with CKD in the pre-dialysis period. The study involved 52 patients with CKD and 23 patients with no kidney disease. In both groups, BMD, body mass index and serum or plasma concentrations of lipids, glucose, creatinine, calcium, phosphorus, parathormone, leptin, adiponectin, osteocalcin, Klotho, and FGF23 were measured...
November 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30396209/normocalcemic-primary-hyperparathyroidism-a-comparison-with-the-hypercalcemic-form-in-a-tertiary-referral-population
#20
Jan Pierreux, Bert Bravenboer
Normocalcemic primary hyperparathyroidism (NPHPT) is a formally recognized variant of primary hyperparathyroidism (PHPT), characterized by normal total and ionized serum calcium concentrations and elevated parathyroid hormone (PTH) levels, in the absence of secondary causes for hyperparathyroidism. NPHPT has been studied previously, but data are limited and confounded. We aimed to compare the clinical and biochemical data of normocalcemic and hypercalcemic subjects in a hospital-based population.We retrospectively analysed the medical records of 131 subjects diagnosed with PHPT at the university hospital Brussels (UZ Brussel) between January 1st 2007 and December 31st 2016, including 25 normocalcemic and 106 hypercalcemic subjects...
November 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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