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Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme

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https://www.readbyqxmd.com/read/30227459/catecholamine-induced-cardiomyopathy-in-pheochromocytoma-how-to-manage-a-rare-complication-in-a-rare-disease
#1
Jenn Rachelle U Santos, Alessandra Brofferio, Bruna Viana, Karel Pacak
Pheochromocytomas and paragangliomas (PHEOs) are rare neuroendocrine tumors. Clinical manifestations include different cardiovascular signs and symptoms, which are related to excessive secretion of catecholamines. Catecholamine-induced cardiomyopathy in PHEO (CICMPP) is a rare but dreaded complication of PHEO. Once patient is diagnosed with this condition, the prognosis is worse and a surgical risk is much higher than expected. This article focuses on how catecholamines affect the heart and the pathophysiologic mechanism of CICMPP...
September 18, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30223288/the-roles-of-il-10-gene-polymorphisms-in-diabetes-mellitus-and-their-associated-complications-a-meta-analysis
#2
Yi Shu, Youping Chen, Haizhao Luo, Huixian Li, Jielong Tang, Yunyi Liang, Weiqiang Liang
The roles of interleukin-10 (IL-10) gene polymorphisms in diabetes mellitus (DM) have been intensively analyzed earlier, but the results of these studies were conflicting. Hence, we performed this study to better assess the relationship between IL-10 genetic variations and DM. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess correlations between IL-10 polymorphisms and DM. A total of 32 studies were finally included in our analyses...
September 17, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30223287/effects-of-parathyroidectomy-on-plasma-ipth-and-1-84-pth-levels-in-patients-with-stage-5-chronic-kidney-disease
#3
Chen Huimin, Cui Ying, Xing Changying, Zha Xiaoming, Zhang Yan, Wang Qingting, Ma Haoyang, Zhang Lina, Zeng Ming, Yang Guang, Lv Xiaolin, Yogendranath Purrunsing, Wang Ningning
Currently, the second-generation intact parathyroid hormone (iPTH) assay is commonly used for measuring PTH levels. The iPTH assay detects both full-length (1-84)PTH and (7-84)PTH fragments, which have antagonistic effects on (1-84)PTH in bones and kidneys. The third-generation PTH assay is specific for (1-84)PTH. This study examined the features of different PTH fragments in stage 5 chronic kidney disease (CKD) and the effects of parathyroidectomy (PTX) on the above markers in severe secondary hyperparathyroidism (SHPT) patients...
September 17, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30216941/higher-hba1c-measurement-quality-standards-are-needed-for-follow-up-and-diagnosis-experience-and-analyses-from-germany
#4
Lutz Heinemann, Patricia Kaiser, Guido Freckmann, Denis Grote-Koska, Wolfgang Kerner, Rüdiger Landgraf, Ludwig Merker, Ulrich A Müller, Dirk Müller-Wieland, Johannes Roth, Michael Spannagl, Henri Wallaschofski, Matthias Nauck
Measurement of HbA1c is an essential laboratory measure for the follow-up and therapy decision-making in patients with diabetes. HbA1c is one of the measurands in laboratory medicine that have to be successfully checked according to the criteria of the guidelines of the German Medical Association (Rili-BAEK) in external quality assurance using the reference method value concept, when applied in patient care. The allowed deviation of ±18% in external quality assessment (EQA) and ± 10% in internal quality control has been ultimately met by virtually all the different manufacturers and methods...
September 14, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30142639/an-update-on-the-histology-of-pheochromocytomas-how-does-it-relate-to-genetics
#5
Lindsey Oudijk, José Gaal, Karen Koopman, Ronald R de Krijger
Pheochromocytomas are rare neuroendocrine tumors of the adrenal gland, whereas any extra-adrenal tumor with similar histology is designated as paraganglioma. These tumors have a very high rate of germline mutations in a large number of genes, up to 35% to 40%, frequently predisposing for other tumors as well. Therefore, they represent a phenomenal challenge for treating physicians. This review focuses on pheochromocytomas only, with special attention to gross and microscopic clues to the diagnosis of genetic syndromes, including the role of succinate dehydrogenase subunit A and subunit B immunohistochemistry as surrogate markers for genetic analysis in the field of succinate dehydrogenase subunit gene mutations...
August 24, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30107619/gut-microbiome-in-balb-c-and-c57bl-6j-mice-undergoing-experimental-thyroid-autoimmunity-associate-with-differences-in-immunological-responses-and-thyroid-function
#6
Sajad Moshkelgosha, Giulia Masetti, Utta Berchner-Pfannschmidt, Hedda Luise Verhasselt, Mareike Horstmann, Salvador Diaz-Cano, Alistair Noble, Barbel Edelman, Danila Covelli, Sue Plummer, Julian R Marchesi, Marian Ludgate, Filippo Biscarini, Anja Eckstein, J Paul Banga
Experimental models of hyperthyroid Graves' disease (GD) and Graves' orbitopathy (GO) are efficiently developed by genetic immunisation by electroporation with human thyrotropin hormone receptor (hTSHR) A-subunit plasmid in female BALB/c (H-2d) mice. We investigated susceptibility in C57BL/6 J (H-2b) animals to allow studies on disease mechanisms in transgenic and immune response gene knock-out mice. Higher numbers of female C57BL/6 J were positive for pathogenic thyroid stimulating antibodies, but induced hyperthyroidism remained at a low frequency compared to BALB/c animals...
August 14, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30096720/mechanistic-pathways-of-selenium-in-the-treatment-of-graves-disease-and-graves-orbitopathy
#7
Michele Marinò, Giovanna Rotondo Dottore, Marenza Leo, Claudio Marcocci
Based on the role of oxidative stress in the pathogenesis of Graves' hyperthyroidism and Graves' orbitopathy, the use of the antioxidant agent selenium has been proposed and several studies on the subject have been conducted, both in vitro and in vivo. Whereas a true benefit related to the use of selenium in patients with Graves' hyperthyroidism has been questioned, its use in patients with mild Graves' orbitopathy is generally believed to be beneficial because of which selenium has entered in the clinical practice for this eye condition...
August 10, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30081426/thyroid-autoimmunity-and-thyroid-cancer-the-pathogenic-connection-a-2018-update
#8
Yuji Nagayama
The association between thyroid cancer and thyroid autoimmunity has long been suggested, but remains to be elucidated for several decades. Here the data on this issue are updated by summarizing relevant papers published between 2012 and early 2018. Although numerous papers demonstrated the significant increase in the prevalence of thyroid autoimmunity (positive intrathyroidal lymphocyte infiltration and/or anti-thyroglobulin/thyroid peroxidase antibodies) in patients with thyroid cancers as compared to those with benign nodules, and also the significant increase in the prevalence of papillary thyroid cancer (PTC) in patients with thyroid autoimmunity as compared to those without, there are some crucial biases that should be taken into account for their interpretation...
August 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30060287/correction-severe-vitamin-d3-deficiency-in-the-majority-of-patients-with-diabetic-foot-ulcers
#9
Joachim Feldkamp, Karsten Jungheim, Matthias Schott, Beatrix Jacobs, Michael Roden
No abstract text is available yet for this article.
July 30, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30241106/correction-higher-hba1c-measurement-quality-standards-are-needed-for-follow-up-and-diagnosis-experience-and-analyses-from-germany
#10
Lutz Heinemann, Patricia Kaiser, Guido Freckmann, Denis Grote-Koska, Wolfgang Kerner, Rüdiger Landgraf, Ludwig Merker, Ulrich A Müller, Dirk Müller-Wieland, Johannes Roth, Michael Spannagl, Henri Wallaschofski, Matthias Nauck
No abstract text is available yet for this article.
October 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30184563/panhypopituitarism-without-gh-replacement-about-insulin-sensitivity-crp-levels-and-metabolic-syndrome
#11
Alejandro Rosell Castillo, Denise Engelbrecht Zantut-Wittmann, Arnaldo Moura Neto, Rodrigo Menezes Jales, Heraldo Mendes Garmes
A complete deficiency of anterior pituitary hormones from several etiologies characterizes Panhypopituitarism (PH). Despite advances in treatment, patients with PH maintain high rates of morbidity and mortality, a reason to investigate some insulin sensitivity, metabolic and inflammatory parameters that could be related to the increase of these indicators. This was a cross-sectional study comprising 41 PH patients under hormonal replacement, except for growth hormone, and 37 individuals in a control group (CG) with similar age, gender and body mass index (BMI)...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30184562/mets-risk-score-a-clear-scoring-model-to-predict-a-3-year-risk-for-metabolic-syndrome
#12
Tian-Tian Zou, Yu-Jie Zhou, Xiao-Dong Zhou, Wen-Yue Liu, Sven Van Poucke, Wen-Jun Wu, Ji-Na Zheng, Xue-Mei Gu, Dong-Chu Zhang, Ming-Hua Zheng, Xiao-Yan Pan
Although several risk factors for metabolic syndrome (MetS) have been reported, there are few clinical scores that predict its incidence. Therefore, we created and validated a risk score for prediction of 3-year risk for MetS. Three-year follow-up data of 4395 initially MetS-free subjects, enrolled for an annual physical examination from Wenzhou Medical Center were analyzed. Subjects at enrollment were randomly divided into the training and the validation cohort. Univariate and multivariate logistic regression models were employed for model development...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30184561/determinants-of-visfatin-nampt-serum-concentration-and-its-leukocyte-expression-in-hyperthyroidism
#13
Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Michał Kloska, Agata Czarnywojtek, Jerzy Sowiński, Bartłomiej Budny, Kosma Woliński, Katarzyna Ziemnicka, Dorota Mańkowska-Wierzbicka, Marek Ruchała
We aimed to analyze the potential influence of thyroid autoimmunity on visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients. This is a single-center, cross-sectional study with consecutive enrollment. All patients with newly diagnosed overt hyperthyroidism in a course of Graves' disease or toxic nodular goiter were included in the study. They underwent physical examination, laboratory investigation, body composition analysis, and thyroid ultrasound. NAMPT mRNA leukocyte expressions were measured using RT-qPCR...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30142638/prostaglandin-e2-activates-nlrp3-inflammasome-in-endothelial-cells-to-promote-diabetic-retinopathy
#14
Yixin Wang, Jianxin Tao, Yong Yao
Proliferative diabetic retinopathy (PDR) is the leading cause of blindness and accounts for approximately 12% of all new cases of blindness. Prostaglandin E2 (PGE2 ) and nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes have been long considered to be associated with PDR. Levels of pro-inflammatory mediators were examined by Enzyme-linked immunosorbent assay (ELISA) measurements. PGE2 levels were analyzed by using the Prostaglandin E2 Monoclonal EIA Kit...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30119135/differential-expression-of-micrornas-and-mir-206-mediated-downregulation-of-bdnf-expression-in-the-rat-fetal-brain-following-maternal-hypothyroidism
#15
Qian Xing, Zhongyan Shan, Yun Gao, Jingyuan Mao, Xiu Liu, Jiashu Yu, Huakun Sun, Chenling Fan, Hong Wang, Hongmei Zhang, Weiping Teng
To investigate the mechanism responsible for the neurological alterations, miRNA expression profile and brain-derived neurotrophic factor (BDNF) were evaluated in brain tissues of fetal or neonatal rats and from maternal rats with hypothyroidism. Ninety female Wistar rats were divided into a control and a hypothyroid group, which were mated. Brain samples of the offspring were obtained at maternal embryonic day (E) E13 and E17 as well as postnatal day (P) P0 and P7, and the hippocampus and cortex were separated at P7...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30081425/effect-of-testosterone-synthesis-and-conversion-on-serum-testosterone-levels-in-obese-men
#16
Xiaolin Xu, Lei Wang, Dandan Luo, Meijie Zhang, Shuhong Chen, Yupeng Wang, Dongmei Zheng, Li Feng, Ling Gao, Chunxiao Yu, Qingbo Guan
Obesity is associated with decreased testosterone levels in males. Testosterone is synthesized by testosterone synthetic enzymes, which are stimulated by luteinizing hormone (LH). Testosterone can also be converted to estradiol via the aromatase. The objective of this study was to examine the factors related to testosterone synthesis and conversion, and to systematically evaluate the key processes that influence testosterone levels in male obesity. Three hundred and two male subjects (aged 25-45 years old) were divided according to BMI into normal weight (18...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30001567/effect-of-prolonged-fasting-duration-on-50-gram-oral-glucose-challenge-test-in-the-diagnosis-of-gestational-diabetes-mellitus
#17
Necati Hancerliogullari, Hatice Kansu Celik, Burcu Kisa Karakaya, Aytekin Tokmak, Yasemin Tasci, Salim Erkaya, Yaprak Engin-Ustun, A Seval Ozgu-Erdinc
The aim of this study was to investigate the association between fasting duration before screening with 50 g glucose challenge test (GCT) and the test outcome. For this cross-sectional study, we enrolled 508 low-risk pregnant women who underwent 50 g GCT between the 24 and 28 weeks of gestation. We excluded women with pregestational diabetes, multiple gestations or a history of gestational diabetes mellitus (GDM), and macrosomia. We evaluated fasting durations, GCT results, and demographic features. A significant positive correlation was found between fasting duration and 50 g GCT values (r=0...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29959763/childhood-craniopharyngioma-a-22-year-challenging-follow-up-in-a-single-center
#18
Patrícia Débora Cavalcanti Tosta-Hernandez, Adriana Aparecida Siviero-Miachon, Nasjla Saba da Silva, Andrea Cappellano, Marcelo de Medeiros Pinheiro, Angela Maria Spinola-Castro
Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30081408/increased-numbers-of-circulating-tumor-cells-in-thyroid-cancer-patients
#19
Margret Ehlers, Stephanie Allelein, Franziska Schwarz, Hubertus Hautzel, Anne Kuebart, Mathias Schmidt, Matthias Haase, Till Dringenberg, Matthias Schott
Circulating tumor cells (CTCs) have been shown to be a valuable prognostic marker for different solid cancers. Within the present study we quantified CTCs in thyroid cancer (TC) patients. Special focus was given to disease-free PTC patients with undetectable serum thyroglobulin (Tg) levels. Altogether, 67 TC patients (33 papillary, 20 follicular, 14 medullary) were included in the study. CTC numbers, which were normalized to 3.3×105 peripheral blood mononuclear cells, were correlated with clinical outcome...
August 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30081407/ultrasonography-classification-of-the-american-thyroid-association-for-predicting-malignancy-in-thyroid-nodules-1cm-with-indeterminate-cytology-a-prospective-study
#20
Tiara Grossi Rocha, Pedro Weslley Rosario, Alexandre Lemos Silva, Maurício Buzelin Nunes, Tulio Henrique Silva, Pedro Henrique Lopes de Oliveira, Maria Regina Calsolari
The objective of this prospective study was to evaluate the ultrasonography classification of the American Thyroid Association (ATA) for predicting malignancy in thyroid nodules >1 cm with indication for fine-needle aspiration (FNA) whose cytology was indeterminate. Additionally, the combination of the ATA classification with Doppler analysis was evaluated. All patients with thyroid nodules >1 cm were eligible. Each nodule was assigned to one of the ATA categories. Exclusively or predominantly intranodular vascularity was considered suspicious...
August 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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