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Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme

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https://www.readbyqxmd.com/read/30001567/effect-of-prolonged-fasting-duration-on-50-gram-oral-glucose-challenge-test-in-the-diagnosis-of-gestational-diabetes-mellitus
#1
Necati Hancerliogullari, Hatice Kansu Celik, Burcu Kisa Karakaya, Aytekin Tokmak, Yasemin Tasci, Salim Erkaya, Yaprak Engin-Ustun, A Seval Ozgu-Erdinc
The aim of this study was to investigate the association between fasting duration before screening with 50 g glucose challenge test (GCT) and the test outcome. For this cross-sectional study, we enrolled 508 low-risk pregnant women who underwent 50 g GCT between the 24 and 28 weeks of gestation. We excluded women with pregestational diabetes, multiple gestations or a history of gestational diabetes mellitus (GDM), and macrosomia. We evaluated fasting durations, GCT results, and demographic features. A significant positive correlation was found between fasting duration and 50 g GCT values (r=0...
July 12, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30001566/altered-glucose-uptake-in-muscle-visceral-adipose-tissue-and-brain-predict-whole-body-insulin-resistance-and-may-contribute-to-the-development-of-type-2-diabetes-a-combined-pet-mr-study
#2
Gretha J Boersma, Emil Johansson, Maria J Pereira, Kerstin Heurling, Stanko Skrtic, Joey Lau, Petros Katsogiannos, Grigorios Panagiotou, Mark Lubberink, Joel Kullberg, Håkan Ahlström, Jan W Eriksson
We assessed glucose uptake in different tissues in type 2 diabetes (T2D), prediabetes, and control subjects to elucidate its impact in the development of whole-body insulin resistance and T2D. Thirteen T2D, 12 prediabetes, and 10 control subjects, matched for age and BMI, underwent OGTT and abdominal subcutaneous adipose tissue (SAT) biopsies. Integrated whole-body 18 F-FDG PET and MRI were performed during a hyperinsulinemic euglycemic clamp to asses glucose uptake rate (MRglu) in several tissues. MRglu in skeletal muscle, SAT, visceral adipose tissue (VAT), and liver was significantly reduced in T2D subjects and correlated positively with M-values (r=0...
July 12, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29975973/severe-vitamin-d3-deficiency-in-the-majority-of-patients-with-diabetic-foot-ulcers
#3
Joachim Feldkamp, Karsten Jungheim, Matthias Schott, Beatrix Jacobs, Michael Roden
Diabetic foot ulcers are a severe complication in patients with diabetes mellitus. Vitamin D is associated with impaired β-cell function and insulin resistance, and is necessary for wound healing and bone metabolism. We measured the serum concentrations of 25-hydroxyvitamin D3 in 104 patients (63 inpatients, 41 outpatients) with diabetic foot ulcers and compared them to 99 healthy humans (control) and 103 patients with diabetes mellitus type 2 without diabetic foot ulcers. Calcium, creatinine, and parathyroid hormone were measured in patients with diabetic foot ulcers...
July 5, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29959763/childhood-craniopharyngioma-a-22-year-challenging-follow-up-in-a-single-center
#4
Patrícia Débora Cavalcanti Tosta-Hernandez, Adriana Aparecida Siviero-Miachon, Nasjla Saba da Silva, Andrea Cappellano, Marcelo de Medeiros Pinheiro, Angela Maria Spinola-Castro
Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models...
June 29, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29954010/high-serum-fractalkine-is-associated-with-lower-trabecular-bone-score-in-premenopausal-women-with-graves-disease
#5
Martin Kužma, Peter Vaňuga, Neil Binkley, Ivana Ságová, Dušan Pávai, Pavel Blažíček, Zuzana Kužmová, Peter Jackuliak, Anton Vaňuga, Zdenko Killinger, Juraj Payer
Chemokine CX3CL1 (fractalkine) may be an important factor linking thyroid status and bone remodeling, through tetrac, a derivative of thyroxine. This study explores the relationship between serum fractalkine levels and parameters of thyroid status and bone in premenopausal women with Graves' disease (GD) in comparison to healthy controls. This cross-sectional study included three premenopausal female groups: active GD; cured GD, and healthy age-, gender-, and BMI-matched controls. Measurement of serum fractalkine levels (Quantikine® ELISA), total amino-terminal peptide of procollagen type 1 (P1NP), CTx, thyroid hormones, BMD and trabecular bone score (TBS) were performed in all study subjects...
June 28, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29895076/a-risk-score-model-for-evaluation-and-management-of-patients-with-thyroid-nodules
#6
Yongwen Zhang, Fanrong Meng, Lianqing Hong, Lanfang Chu
The study is aimed to establish a simplified and practical tool for analyzing thyroid nodules. A novel risk score model was designed, risk factors including patient history, patient characteristics, physical examination, symptoms of compression, thyroid function, ultrasonography (US) of thyroid and cervical lymph nodes were evaluated and classified into high risk factors, intermediate risk factors, and low risk factors. A total of 243 thyroid nodules in 162 patients were assessed with risk score system and Thyroid Imaging-Reporting and Data System (TI-RADS)...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29895075/psychological-symptoms-and-well-being-after-treatment-for-primary-aldosteronism
#7
Marieke S Velema, Jannie M Terlouw, Aline H de Nooijer, Marjan D Nijkamp, Nele Jacobs, Jaap Deinum
Primary aldosteronism (PA) is an increasingly identified cause of secondary hypertension. PA can be caused by an aldosterone-producing adenoma or by bilateral adrenal hyperplasia, generally treated by adrenalectomy or mineralocorticoid receptor antagonists, respectively. Recent studies suggest that PA is associated with more psychological symptoms and lower levels of well-being. The purpose of this study was to investigate the associations between subtype of PA and psychological symptoms and well-being after specific treatment...
June 12, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29895074/relation-of-rankl-and-opg-levels-with-bone-resorption-in-patients-with-acromegaly-and-prolactinoma
#8
Firuzan Firat Ozer, Selcuk Dagdelen, Tomris Erbas
The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and acromegaly. Thirty-one patients with acromegaly, 28 patients with prolactinoma, and 33 healthy individuals were included in the study. Serum concentrations of RANKL, OPG, bone alkaline phosphatase (bone ALP), osteocalcin (OC), C-terminal telopeptide of type 1 collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP) and urine deoxypyridinoline (DPD) levels were detected and bone mineral density (BMD) was measured...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29719878/increasing-body-mass-index-predicts-rapid-decline-in-renal-function-a-5-year-retrospective-study
#9
Xiaojing Ma, Chengyin Zhang, Hong Su, Xiaojie Gong, Xianglei Kong
While obesity is a recognized risk factor for chronic kidney disease, it remains unclear whether change in body mass index (ΔBMI ) is independently associated with decline in renal function (evaluated by the change in estimated glomerular filtration rate, ΔeGFR) over time. Accordingly, to help clarify this we conducted a retrospective study to measure the association of ΔBMI with decline in renal function in Chinese adult population. A total of 4007 adults (aged 45.3±13.7 years, 68.6% male) without chronic kidney disease at baseline were enrolled between 2008 and 2013...
May 2, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29991086/diabetes-mellitus-and-autoimmune-hepatitis-demographical-and-clinical-description-of-a-relatively-rare-phenotype
#10
Gideon de Sousa, Nicole Prinz, Marianne Becker, Renate Dürr, Uta Faller, Dagmar Meraner, Nicolai Heise, Illa Engelmann, Herbert Bruckmayer, Dagobert Wiemann, Maria Fritsch, Bernd Stratmann, Reinhard W Holl
We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. A total of 139 patients with diabetes and AIH were analyzed and compared to 437 728 patients with diabetes without AIH. The prevalence of AIH in patients with T1DM (44.8/100 000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6/100 000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29991085/could-lipid-profile-be-used-as-a-marker-of-autonomous-cortisol-secretion-in-patients-with-adrenal-incidentalomas
#11
Gesthimani Mintziori, Thomas Georgiou, Panagiotis Anagnostis, Fotini Adamidou, Zoe Efstathiadou, Athanasios Panagiotou, Marina Kita
Adrenal incidentalomas (AIs) have been associated with an increased risk of metabolic syndrome and dyslipidemia, though evidence regarding the latter is limited. Lipid abnormalities in patients with AIs have been associated with subclinical hypercortisolism. The current study aims to test whether lipid profile in patients with AIs predicts "autonomous cortisol secretion" (ACS). Patients with AIs found on either computerized tomography (CT) or magnetic resonance imaging (MRI), were included in a prospective cohort study...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29991084/thyroid-autoantibodies-do-not-impair-the-ovarian-reserve-in-euthyroid-infertile-women-a-cross-sectional-study
#12
Satoko Osuka, Akira Iwase, Maki Goto, Sachiko Takikawa, Tomoko Nakamura, Tomohiko Murase, Nao Kato, Tomomi Kotani, Fumitaka Kikkawa
Patients with primary ovarian insufficiency (POI) have a high prevalence of thyroid autoimmune disorders. However, the extent of the contribution of thyroid autoantibodies or elevated thyroid-stimulating hormone (TSH) levels to decreased ovarian reserve is unclear. Therefore, we evaluated the serum levels of anti-Müllerian hormone (AMH) and thyroid autoantibodies [antithyroperoxidase antibody (TPOAb), and antithyroglobulin antibody (TgAb)] in euthyroid infertile women. One hundred and fifty-three women with normal menstrual cycles were recruited for this retrospective study...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29991083/correlation-between-resistin-level-and-metabolic-syndrome-component-a-review
#13
Mostafa Mostafazadeh, Sanya Haiaty, Ali Rastqar, Mahtab Keshvari
Metabolic syndrome (MetS) has a collection of some abnormal and pathological conditions that cause many critical diseases. Resistin is one of the possible candidates for these pathologies but there are not enough data to prove if resistin has positive, neutral, or negative effects on one or some components of MetS. This review summarizes data about comparing the effects and contribution of resistin in initiation and progression of MetS components and also its different actions between human and other mammalians...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29991082/association-of-serum-leptin-with-all-cause-and-disease-specific-mortality-a-meta-analysis-of-prospective-observational-studies
#14
Hamed Kord-Varkaneh, Somaye Fatahi, Shahab Alizadeh, Ehsan Ghaedi, Sakineh Shab-Bidar
Leptin levels may affect mortality through its link to inflammation and obesity. However, data are inconclusive. This meta-analysis was performed to investigate the association of leptin with mortality. The PubMed, Scopus, Google scholar, and reference lists of the included studies were searched for all published prospective observational studies that described the associations of serum leptin and mortality up to August 2017. Two reviewers independently assessed all potentially relevant studies for inclusion and methodological quality using standardized abstraction forms...
July 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883975/short-term-and-long-term-effects-of-bisphenol-a-bpa-exposure-during-breastfeeding-on-the-biochemical-and-endocrine-profiles-in-rats
#15
Ana P Santos-Silva, Egberto Gaspar de Moura, Cintia R Pinheiro, Elaine Oliveira, Patricia Cristina Lisboa
Neonates can be exposed to bisphenol A (BPA) through placenta and milk, and BPA is associated with disorders such as precocious puberty and obesity. We evaluated the effects of BPA exposure during breastfeeding on the biochemical and endocrine profiles in young and adult rat progeny. From postnatal day (PND) 3 to 15 dams were divided into low-dose BPA treatment [50 μg/kg/day s.c. (BPA-LD)], high-dose BPA treatment [5 mg/kg/day s.c. (BPA-HD)], and Control (vehicle) groups. Milk was collected at PND15 and 21, which represents the end of exposure and 6 days after withdrawal, respectively...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883974/cardiovascular-effects-of-stress-during-acutely-increased-free-fatty-acids-in-a-randomized-double-blind-cross-over-study-in-humans
#16
Safoura Sheikh Rezaei, Brigitte Litschauer, Gazaleh Gouya, Sabina Baumgartner-Parzer, Thomas Stulnig, Michael Wolzt
Increased free fatty acids stimulate sympathetic nervous system activity, impair endothelium-dependent vasodilation, and increase regional blood flow. The aim of this study was to assess if fatty acids acutely elevated by infusion of intralipid/heparin affect cardiovascular reactivity employing two stressors eliciting either a cardiac (Stroop test) or vascular (Cold Face test) dominated pressor response. Two stress tasks were performed in 20 healthy subjects (10 women, 10 men) before and during a 180-min intralipid/heparin or saline infusion as placebo on alternate trial days in a randomized crossover study design...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883973/associations-of-estrogen-receptor-alpha-gene-polymorphisms-with-type-2-diabetes-mellitus-and-metabolic-syndrome-a-systematic-review-and-meta-analysis
#17
Jiajia Yang, Renfang Han, Mengya Chen, Yaping Yuan, Xingxing Hu, Yubo Ma, Meng Wu, Xu Zhang, Mengmeng Wang, Shanqun Jiang, Faming Pan
The associations between PvuII (T>C) and XbaI (A>G) polymorphisms of estrogen receptor alpha (ESR1) gene with type 2 diabetes mellitus (T2DM) or metabolic syndrome (MetS) are reported in many studies, but the results are inconsistent. This present work aims to assess the associations by performing a comprehensive meta-analysis. Relevant studies were searched through several databases. The pooled odd ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of PvuII and XbaI polymorphisms with the risk of T2DM and MetS by using the STATA 14...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883972/correlation-between-the-responses-to-growth-hormone-gh-treatment-during-childhood-and-adulthood-in-a-monocentric-cohort-of-gh-deficient-patients
#18
Sarah Thilmany, Leila Mchirgui, Chloé Brunelle, Véronique Beauloye, Dominique Maiter, Orsalia Alexopoulou
Our aim was to analyze a cohort of patients with childhood-onset growth hormone deficiency (GHD) to evaluate if there is some correlation between the response to GH treatment during childhood and adulthood, respectively. This was an observational retrospective monocentric cohort study of 47 patients treated with GH during childhood and adulthood. Changes in growth parameters during childhood were compared with the increase of IGF-I z-score and other indexes of GH response (body composition, lipid profile) after 1 year of treatment in adulthood...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883971/an-overview-of-fgf19-and-fgf21-the-therapeutic-role-in-the-treatment-of-the-metabolic-disorders-and-obesity
#19
Nasim Babaknejad, Hashem Nayeri, Roohullah Hemmati, Somaye Bahrami, Ahmad Esmaillzadeh
Fibroblast growth factors (FGFs) are responsible for the regulation of a wide range of biological functions, among which cellular proliferation, survival, migration, and differentiation could be pointed out. FGF19 controls the enterohepatic bile acid/cholesterol system, and FGF21 modulates fatty acid/glucose metabolism. Obesity, type 2 diabetes, coronary artery disease, and cancer, all can alter FGF21 circulating concentrations. In contrast to FGF21, metabolic diseases exhibit reduced serum FGF19 levels. Accordingly, FGF19 and FGF21 play important roles in regulating glucose and lipid metabolism...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883970/the-effects-of-vitamin-d-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-in-diabetic-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Mohammad Ali Mansournia, Vahidreza Ostadmohammadi, Amin Doosti-Irani, Majid Ghayour-Mobarhan, Gordon Ferns, Hossein Akbari, Amir Ghaderi, Hamid Reza Talari, Zatollah Asemi
In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI)...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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