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Pathology

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https://www.readbyqxmd.com/read/28427753/prognostic-markers-in-oropharyngeal-squamous-cell-carcinoma-focus-on-cd70-and-tumour-infiltrating-lymphocytes
#1
Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Karen Zwaenepoel, Philippe Deron, Fréderic Duprez, Sylvie Rottey, Liesbeth Ferdinande
We evaluated the expression of CD70 as biomarker for prognosis in patients with oropharyngeal squamous cell carcinoma (OSCC). We also examined the prognostic value of tumour infiltrating lymphocytes (TILs) in our study cohort. Formalin fixed, paraffin embedded tissue originating from the oropharynx of 78 patients was immunohistochemically stained for CD70, CD3, CD8 and FoxP3. Expression of CD70, CD3, CD8, FoxP3 and HPV status was correlated with clinicopathological characteristics. Overall survival (OS) was determined by a log-rank (Mantel-Cox) test whereas the Cox proportional hazard model was used for multivariate analysis...
April 17, 2017: Pathology
https://www.readbyqxmd.com/read/28302324/corrigendum-to-kasem-k-gopalan-v-saremi-n-olveda-d-pillai-s-salajegheh-a-petcu-e-leung-m-lam-aky-enhancing-pathology-learning-experience-of-medical-students-using-multiple-advanced-learning-and-teaching-strategies-pathology-2016-48-supplement-1-s57
#2
https://www.readbyqxmd.com/read/28285720/absence-of-gnas-and-braf-mutations-but-presence-of-kras-mutation-in-urachal-adenocarcinoma
#3
LETTER
Jen-Fan Hang, Chin-Chen Pan
No abstract text is available yet for this article.
March 9, 2017: Pathology
https://www.readbyqxmd.com/read/28279476/missed-detection-of-an-avian-influenza-a-h7n9-virus-by-the-luminex-xtag-respiratory-viral-panel-fast-version-2
#4
LETTER
Chun Kiat Lee, Lily-Lily Chiu, Tze Ping Loh, Evelyn Siew-Chuan Koay
No abstract text is available yet for this article.
March 6, 2017: Pathology
https://www.readbyqxmd.com/read/28274666/trophoblastic-regression-of-amnion-implications-for-amnion-transplants
#5
LETTER
T Y Khong
No abstract text is available yet for this article.
March 6, 2017: Pathology
https://www.readbyqxmd.com/read/28274669/response-to-comparison-of-infliximab-drug-measurement-across-three-commercially-available-elisa-kits
#6
LETTER
D Nagore, N Rapún, I Antón, J Harper, A Martínez
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274667/response-to-comparison-of-infliximab-drug-measurement-across-three-commercially-available-elisa-kits-author-reply
#7
LETTER
Catherine Mei-Ling Toong, Monique Wei Meng Lee, Susan Connor, Watson Ng
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274665/introduction-of-a-rapid-diagnostic-dengue-ns1-antigen-igm-igg-combination-assay-associated-with-a-reduced-inpatient-length-of-stay
#8
LETTER
Johanna K Mayer, Kevin Freeman, Robert W Baird
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28267996/primary-hyperparathyroidism-manifesting-with-pancytopenia
#9
LETTER
Jessica Opie, Fierdoz Omar, Hsin-Chi Huang, Laurence Sandler, Ian Ross
No abstract text is available yet for this article.
March 4, 2017: Pathology
https://www.readbyqxmd.com/read/28249686/malignant-adenomyoepithelioma-of-the-breast
#10
LETTER
Martin Jones, Julie Fletcher
No abstract text is available yet for this article.
February 26, 2017: Pathology
https://www.readbyqxmd.com/read/28245936/metastatic-primary-peritoneal-malignant-mesothelioma-mimicking-primary-diffuse-gastric-carcinoma-a-rare-encounter-in-gastric-biopsy
#11
LETTER
Yanling Yang, Dimuth Gunawardane, David Moffat, Christopher Carter
No abstract text is available yet for this article.
February 25, 2017: Pathology
https://www.readbyqxmd.com/read/28291548/the-role-of-interleukin-17a-in-the-pathogenesis-of-kidney-diseases
#12
REVIEW
Charlotte Cortvrindt, Reinhart Speeckaert, Alena Moerman, Joris R Delanghe, Marijn M Speeckaert
Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4(+)αβ T cells, γδ T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases...
April 2017: Pathology
https://www.readbyqxmd.com/read/28279477/the-evolution-of-differentiated-thyroid-cancer
#13
REVIEW
Sylvia L Asa
Differentiated thyroid tumours of follicular cell derivation have traditionally been classified based on architecture, cytology, or both. The features that distinguish the various entities are controversial and diagnostic criteria are inconsistent and often irreproducible. The complexity of classification schemes has not been substantiated by molecular profiling. In this review, a simplistic approach to the diagnosis of well differentiated thyroid neoplasia is provided to challenge the dogma. The proposed classification matches the molecular profiles of these lesions and simplifies the criteria for diagnosis...
April 2017: Pathology
https://www.readbyqxmd.com/read/28274671/second-opinion-oral-pathology-referrals-in-new-zealand
#14
B Seo, H M Hussaini, A M Rich
Referral for a second opinion is an important aspect of pathology practice, which reduces the rate of diagnostic error and ensures consistency with diagnoses. The Oral Pathology Centre (OPC) is the only specialist oral diagnostic centre in New Zealand. OPC provides diagnostic services to dentists and dental specialists throughout New Zealand and acts as a referral centre for second opinions for oral pathology specimens that have been sent to anatomical pathologists. The aim of this study was to review second opinion referral cases sent to the OPC over a 15-year period and to assess the levels of concordance between the original and final diagnoses...
April 2017: Pathology
https://www.readbyqxmd.com/read/28274670/detection-of-copy-number-variations-in-melanocytic-lesions-utilising-array-based-comparative-genomic-hybridisation
#15
Nima Mesbah Ardakani, Carla Thomas, Cleo Robinson, Kym Mina, Nathan Tobias Harvey, Benhur Amanuel, Benjamin Andrew Wood
Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and utility of array-based comparative genomic hybridisation (aCGH) to assess CNVs in melanocytic lesions. DNA was extracted from formalin fixed, paraffin embedded (FFPE) sections of unambiguous naevi (n=19) and melanomas (n=19)...
April 2017: Pathology
https://www.readbyqxmd.com/read/28274668/diagnostic-problems-in-spitzoid-neoplasms
#16
LETTER
Carmelo Urso
No abstract text is available yet for this article.
April 2017: Pathology
https://www.readbyqxmd.com/read/28267995/enteroliths-and-multiple-neuroendocrine-tumours-in-a-meckel-s-diverticulum
#17
LETTER
Tony Dill, Ella Sugo, Brendan McManus
No abstract text is available yet for this article.
April 2017: Pathology
https://www.readbyqxmd.com/read/28259358/prognostic-significance-of-lymphatic-vascular-and-perineural-invasion-for-bladder-cancer-patients-treated-by-radical-cystectomy
#18
Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A Boorjian, R Jeffrey Karnes, R Houston Thompson, Prabin Thapa, Robert F Tarrell, Loren P Herrera Hernandez, Rafael E Jimenez, John C Cheville
In radical cystectomy specimens with bladder cancer, lymphatic and vascular invasion are often reported as 'angiolymphatic' or 'lymphovascular' invasion, terms that combine the findings of tumour within simple endothelial-lined lymphatic spaces and tumour within muscle-lined blood vessels. It is unclear if these patterns of invasion have different prognostic significance. In addition, there are conflicting data regarding the significance of lymphatic, vascular and perineural invasion in patients with bladder cancer...
April 2017: Pathology
https://www.readbyqxmd.com/read/28256213/update-on-molecular-findings-in-rhabdomyosarcoma
#19
REVIEW
Dina El Demellawy, Jean McGowan-Jordan, Joseph de Nanassy, Elizaveta Chernetsova, Ahmed Nasr
Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour in children and adolescents. Histologically RMS resembles developing fetal striated skeletal muscle. RMS is stratified into different histological subtypes which appear to influence management plans and patient outcome. Importantly, molecular classification of RMS seems to more accurately capture the true biology and clinical course and prognosis of RMS to guide therapeutic decisions. The identification of PAX-FOXO1 fusion status in RMS is one of the most important updates in the risk stratification of RMS...
April 2017: Pathology
https://www.readbyqxmd.com/read/28238418/foxa1-is-expressed-in-ovarian-mucinous-neoplasms
#20
Georgia Karpathiou, Melany Venet, Mousa Mobarki, Fabien Forest, Celine Chauleur, Michel Peoc'h
FOXA1 is a transcription factor essential for the binding and action of other transcription factors on the chromatin. It is the major regulator of endoderm differentiation. It has important roles in breast, prostate and endometrial cancer. It has never been studied in ovarian tumours. The aim of this study was to investigate its expression in ovarian epithelial neoplasms. A total of 195 primary ovarian epithelial borderline or malignant tumours were immunohistochemically studied for the expression of FOXA1...
April 2017: Pathology
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