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Pathology

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https://www.readbyqxmd.com/read/29678480/gram-negative-anaerobe-susceptibility-testing-in-clinical-isolates-using-sensititre-and-etest-methods
#1
C Hughes, C Ashhurst-Smith, J K Ferguson
Gram negative anaerobic organisms are important pathogens in a range of clinical infections, and susceptibility testing is not commonly performed in the microbiology laboratory. We performed anaerobic susceptibility testing on 70 clinically relevant Gram negative anaerobes isolated from routine cultures in a busy diagnostic laboratory which were identified by MALDI-TOF mass spectrometry (MALDI-TOF MS). The susceptibility testing was performed by two methods: Sensititre trays (ThermoFisher Scientific) against 15 different antibiotics, and Etests (bioMérieux) against five clinically relevant antibiotics (metronidazole, piperacillin-tazobactam, amoxicillin-clavulanate, meropenem and clindamycin)...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29678479/hit-or-miss-a-comprehensive-contemporary-investigation-of-laboratory-tests-for-heparin-induced-thrombocytopenia
#2
Emmanuel J Favaloro, Georgia McCaughan, Soma Mohammed, Kun Kan Edwin Lau, Rosalie Gemmell, Lauren Cavanaugh, Dea Donikian, Mayuko Kondo, Timothy Brighton, Leonardo Pasalic
Heparin induced thrombocytopenia (HIT) is a rare but potentially fatal complication of heparin therapy, which in a proportion of patients causes platelet activation and thrombosis. Initial clinical assessment of the likelihood of HIT is facilitated by laboratory testing to confirm or exclude HIT. This prospective investigation was performed over an 18-month period, and has involved testing of over 300 test samples from over 100 consecutive patients. Clinical assessment by 4T score was supplemented by laboratory tests that comprised both immunological [lateral flow ('STiC'), chemiluminescence (AcuStar; HIT-IgG(PF4-H) ), ELISA (Asserachrom HPIA IgG)] and functional assays [SRA, platelet aggregation using whole blood ('Multiplate') and platelet rich plasma ('LTA')]...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29678478/immunohistochemical-cd271-expression-correlates-with-melanoma-progress-in-a-case-control-study
#3
Patricia Switten Nielsen, Rikke Riber-Hansen, Torben Steiniche
Putative cancer stem cell (CSC) markers have arisen from melanoma mouse and in vitro models, but their expression in paraffin embedded patient samples relative to clinical outcome remains largely unexplored. Rather than cells of the tumour bulk, conceivably, CSC drive tumour progression. Accordingly, complete eradication may prevent melanoma relapse. Because elevated tumour-cell proliferation is an established indicator of aggressive disease, this study aimed to investigate the correlation between melanoma recurrence and proliferation of putative CSC that express CD271, CD166, or CD20...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29665965/anatomical-pathology-is-at-a-crossroads
#4
EDITORIAL
Thomas James Flotte, Debra Ann Bell
No abstract text is available yet for this article.
April 14, 2018: Pathology
https://www.readbyqxmd.com/read/29631726/impact-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-the-bethesda-system-for-reporting-thyroid-cytopathology-a-multi-institutional-study-in-five-asian-countries
#5
Andrey Bychkov, Somboon Keelawat, Shipra Agarwal, Deepali Jain, Chan Kwon Jung, SoonWon Hong, Chiung-Ru Lai, Shinya Satoh, Kennichi Kakudo
Several Western studies showed that the recent introduction of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) significantly decreased risk of malignancy for cytological diagnostic categories. We aimed to determine the impact of NIFTP on risk of malignancy within a cohort of thyroid nodules from Asian countries, and to compare distribution of diagnostic categories between NIFTP and invasive encapsulated follicular variant of papillary thyroid carcinoma (eFV-PTC). Consecutive thyroid fine-needle aspirates from six institutions were retrospectively analysed...
April 6, 2018: Pathology
https://www.readbyqxmd.com/read/29625709/digital-pathology-quo-vadis
#6
EDITORIAL
Eric F Glassy
No abstract text is available yet for this article.
April 3, 2018: Pathology
https://www.readbyqxmd.com/read/29551390/routine-susceptibility-testing-for-candida-albicans-isolated-from-blood-stream-infections
#7
LETTER
Saugata Choudhury
No abstract text is available yet for this article.
March 16, 2018: Pathology
https://www.readbyqxmd.com/read/29506751/braf-gene-rearrangements-can-be-identified-by-fish-studies-in-pancreatic-acinar-cell-carcinoma
#8
LETTER
Angela Chou, Yoomee Kim, Jaswinder S Samra, Marina Pajic, Anthony J Gill
No abstract text is available yet for this article.
March 2, 2018: Pathology
https://www.readbyqxmd.com/read/29506750/response-to-high-grade-squamous-intraepithelial-lesion-hsil-of-the-cervix-with-bizarre-cytological-appearances-pleomorphic-hsil-author-reply
#9
LETTER
https://www.readbyqxmd.com/read/29499872/antifungal-susceptibility-testing-in-australasian-clinical-laboratories-we-must-improve-our-performance
#10
EDITORIAL
Sarah E Kidd, Catriona L Halliday, Arthur J Morris, Sharon C-A Chen
No abstract text is available yet for this article.
February 27, 2018: Pathology
https://www.readbyqxmd.com/read/29499871/combined-ovarian-serous-cystadenoma-and-thecoma
#11
LETTER
Mudiwa Muronda, Peter Russell
No abstract text is available yet for this article.
February 27, 2018: Pathology
https://www.readbyqxmd.com/read/29496201/localised-lymphoedema-forming-a-papillated-lesion-on-the-scalp
#12
LETTER
Jasmin Dvorah Korbl, Jonathan Chan, Benjamin Andrew Wood, Nathan Tobias Harvey
No abstract text is available yet for this article.
February 26, 2018: Pathology
https://www.readbyqxmd.com/read/29496200/-why-don-t-they-ever-call-expectations-of-clinicians-and-pathologists-regarding-the-communication-of-critical-diagnoses-in-dermatopathology
#13
Jasmin Dvorah Korbl, Benjamin Andrew Wood, Nathan Tobias Harvey
Certain diagnoses in dermatopathology have significant implications for patient management and on occasion appropriate clinical care may be facilitated by a phone call from the reporting dermatopathologist to the referring doctor. Whether this is appropriate depends on a number of factors. The concept of 'critical diagnoses' is now well established in surgical pathology, having evolved from critical value policies in clinical pathology and haematology. However, only limited attempts have been made to assess perceptions among different clinical groups...
February 26, 2018: Pathology
https://www.readbyqxmd.com/read/29490872/pigmented-paget-s-disease-of-the-nipple-mistaken-for-melanoma-in-situ-a-diagnostic-pitfall-for-the-unwary
#14
LETTER
Annalisa Solinas, Annabelle Mahar, Wendy A Cooper, John F Thompson, Andrew J Spillane, Richard A Scolyer
No abstract text is available yet for this article.
February 26, 2018: Pathology
https://www.readbyqxmd.com/read/29490871/response-to-high-grade-squamous-intraepithelial-lesion-hsil-of-the-cervix-with-bizarre-cytological-appearances-pleomorphic-hsil
#15
LETTER
Ondrej Ondič, Reza Alaghehbandan
No abstract text is available yet for this article.
February 25, 2018: Pathology
https://www.readbyqxmd.com/read/29486963/indolent-t-lymphoblastic-proliferation-associated-with-low-grade-follicular-dendritic-cell-sarcoma-and-castleman-disease
#16
LETTER
Andrés E Quesada, Ken H Young, L Jeffrey Medeiros, Beenu Thakral
No abstract text is available yet for this article.
February 24, 2018: Pathology
https://www.readbyqxmd.com/read/29478693/incidental-single-organ-vasculitis-of-the-appendix
#17
LETTER
Norman J Carr
No abstract text is available yet for this article.
February 22, 2018: Pathology
https://www.readbyqxmd.com/read/29478692/inflammatory-myofibroblastic-tumours-of-the-head-and-neck
#18
LETTER
Harini Narayanappa, Tsu-Hui Hubert Low, Ana Cristina Vargas Calderon, Christina Selinger, Ruta Gupta
No abstract text is available yet for this article.
February 22, 2018: Pathology
https://www.readbyqxmd.com/read/29477276/real-world-experience-of-brafv600e-mutation-specific-immunohistochemistry-in-colorectal-carcinoma
#19
LETTER
Jessica Reagh, Adele Clarkson, Martyn Bullock, Phillip Shepherd, Anthony J Gill
No abstract text is available yet for this article.
February 21, 2018: Pathology
https://www.readbyqxmd.com/read/29455870/detection-and-incidence-of-bordetella-holmesii-in-respiratory-specimens-from-patients-with-pertussis-like-symptoms-in-new-south-wales-australia
#20
Winkie Fong, Verlaine Timms, Nadine Holmes, Vitali Sintchenko
Bordetella pertussis, the aetiological agent of whooping cough is routinely diagnosed by polymerase chain reaction (PCR) directed at IS481, an insertion sequence target also found in Bordetella holmesii. Recent reports have suggested that B. holmesii infections can be misdiagnosed as pertussis, which can have a significant impact on public health surveillance. This study investigated the presence of B. holmesii in B. pertussis positive clinical samples, in order to determine the incidence of B. holmesii. Clinical cases of pertussis diagnosed by IS481-specific PCR between October 2008 and March 2016 in New South Wales were included...
February 15, 2018: Pathology
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