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Pathology

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https://www.readbyqxmd.com/read/28302324/corrigendum-to-kasem-k-gopalan-v-saremi-n-olveda-d-pillai-s-salajegheh-a-petcu-e-leung-m-lam-aky-enhancing-pathology-learning-experience-of-medical-students-using-multiple-advanced-learning-and-teaching-strategies-pathology-2016-48-supplement-1-s57
#1
https://www.readbyqxmd.com/read/28291548/the-role-of-interleukin-17a-in-the-pathogenesis-of-kidney-diseases
#2
REVIEW
Charlotte Cortvrindt, Reinhart Speeckaert, Alena Moerman, Joris R Delanghe, Marijn M Speeckaert
Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4(+)αβ T cells, γδ T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases...
March 10, 2017: Pathology
https://www.readbyqxmd.com/read/28285720/absence-of-gnas-and-braf-mutations-but-presence-of-kras-mutation-in-urachal-adenocarcinoma
#3
LETTER
Jen-Fan Hang, Chin-Chen Pan
No abstract text is available yet for this article.
March 9, 2017: Pathology
https://www.readbyqxmd.com/read/28279477/the-evolution-of-differentiated-thyroid-cancer
#4
Sylvia L Asa
Differentiated thyroid tumours of follicular cell derivation have traditionally been classified based on architecture, cytology, or both. The features that distinguish the various entities are controversial and diagnostic criteria are inconsistent and often irreproducible. The complexity of classification schemes has not been substantiated by molecular profiling. In this review, a simplistic approach to the diagnosis of well differentiated thyroid neoplasia is provided to challenge the dogma. The proposed classification matches the molecular profiles of these lesions and simplifies the criteria for diagnosis...
March 6, 2017: Pathology
https://www.readbyqxmd.com/read/28279476/missed-detection-of-an-avian-influenza-a-h7n9-virus-by-the-luminex-xtag-respiratory-viral-panel-fast-version-2
#5
LETTER
Chun Kiat Lee, Lily-Lily Chiu, Tze Ping Loh, Evelyn Siew-Chuan Koay
No abstract text is available yet for this article.
March 6, 2017: Pathology
https://www.readbyqxmd.com/read/28274666/trophoblastic-regression-of-amnion-implications-for-amnion-transplants
#6
LETTER
T Y Khong
No abstract text is available yet for this article.
March 6, 2017: Pathology
https://www.readbyqxmd.com/read/28274671/second-opinion-oral-pathology-referrals-in-new-zealand
#7
B Seo, H M Hussaini, A M Rich
Referral for a second opinion is an important aspect of pathology practice, which reduces the rate of diagnostic error and ensures consistency with diagnoses. The Oral Pathology Centre (OPC) is the only specialist oral diagnostic centre in New Zealand. OPC provides diagnostic services to dentists and dental specialists throughout New Zealand and acts as a referral centre for second opinions for oral pathology specimens that have been sent to anatomical pathologists. The aim of this study was to review second opinion referral cases sent to the OPC over a 15-year period and to assess the levels of concordance between the original and final diagnoses...
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274670/detection-of-copy-number-variations-in-melanocytic-lesions-utilising-array-based-comparative-genomic-hybridisation
#8
Nima Mesbah Ardakani, Carla Thomas, Cleo Robinson, Kym Mina, Nathan Tobias Harvey, Benhur Amanuel, Benjamin Andrew Wood
Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and utility of array-based comparative genomic hybridisation (aCGH) to assess CNVs in melanocytic lesions. DNA was extracted from formalin fixed, paraffin embedded (FFPE) sections of unambiguous naevi (n=19) and melanomas (n=19)...
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274669/response-to-comparison-of-infliximab-drug-measurement-across-three-commercially-available-elisa-kits
#9
LETTER
D Nagore, N Rapún, I Antón, J Harper, A Martínez
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274668/diagnostic-problems-in-spitzoid-neoplasms
#10
LETTER
Carmelo Urso
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274667/response-to-comparison-of-infliximab-drug-measurement-across-three-commercially-available-elisa-kits-author-reply
#11
LETTER
Catherine Mei-Ling Toong, Monique Wei Meng Lee, Susan Connor, Watson Ng
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28274665/introduction-of-a-rapid-diagnostic-dengue-ns1-antigen-igm-igg-combination-assay-associated-with-a-reduced-inpatient-length-of-stay
#12
LETTER
Johanna K Mayer, Kevin Freeman, Robert W Baird
No abstract text is available yet for this article.
March 5, 2017: Pathology
https://www.readbyqxmd.com/read/28267996/primary-hyperparathyroidism-manifesting-with-pancytopenia
#13
LETTER
Jessica Opie, Fierdoz Omar, Hsin-Chi Huang, Laurence Sandler, Ian Ross
No abstract text is available yet for this article.
March 4, 2017: Pathology
https://www.readbyqxmd.com/read/28267995/enteroliths-and-multiple-neuroendocrine-tumours-in-a-meckel-s-diverticulum
#14
LETTER
Tony Dill, Ella Sugo, Brendan McManus
No abstract text is available yet for this article.
March 4, 2017: Pathology
https://www.readbyqxmd.com/read/28259358/prognostic-significance-of-lymphatic-vascular-and-perineural-invasion-for-bladder-cancer-patients-treated-by-radical-cystectomy
#15
Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A Boorjian, R Jeffrey Karnes, R Houston Thompson, Prabin Thapa, Robert F Tarrell, Loren P Herrera Hernandez, Rafael E Jimenez, John C Cheville
In radical cystectomy specimens with bladder cancer, lymphatic and vascular invasion are often reported as 'angiolymphatic' or 'lymphovascular' invasion, terms that combine the findings of tumour within simple endothelial-lined lymphatic spaces and tumour within muscle-lined blood vessels. It is unclear if these patterns of invasion have different prognostic significance. In addition, there are conflicting data regarding the significance of lymphatic, vascular and perineural invasion in patients with bladder cancer...
March 1, 2017: Pathology
https://www.readbyqxmd.com/read/28256213/update-on-molecular-findings-in-rhabdomyosarcoma
#16
Dina El Demellawy, Jean McGowan-Jordan, Joseph de Nanassy, Elizaveta Chernetsova, Ahmed Nasr
Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour in children and adolescence. Histologically RMS resembles developing fetal striated skeletal muscle. RMS is stratified into different histological subtypes which appear to influence management plans and patients outcome. Importantly, molecular classification of RMS seems to more accurately capture the true biology and clinical course and prognosis of RMS to guide therapeutic decisions. The identification of PAX-FOXO1 fusion status in RMS is one of the most important updates in the risk stratification of RMS...
February 27, 2017: Pathology
https://www.readbyqxmd.com/read/28249686/malignant-adenomyoepithelioma-of-the-breast
#17
LETTER
Martin Jones, Julie Fletcher
No abstract text is available yet for this article.
February 26, 2017: Pathology
https://www.readbyqxmd.com/read/28245936/metastatic-primary-peritoneal-malignant-mesothelioma-mimicking-primary-diffuse-gastric-carcinoma-a-rare-encounter-in-gastric-biopsy
#18
LETTER
Yanling Yang, Dimuth Gunawardane, David Moffat, Christopher Carter
No abstract text is available yet for this article.
February 25, 2017: Pathology
https://www.readbyqxmd.com/read/28238418/foxa1-is-expressed-in-ovarian-mucinous-neoplasms
#19
Georgia Karpathiou, Melany Venet, Mousa Mobarki, Fabien Forest, Celine Chauleur, Michel Peoc'h
FOXA1 is a transcription factor essential for the binding and action of other transcription factors on the chromatin. It is the major regulator of endoderm differentiation. It has important roles in breast, prostate and endometrial cancer. It has never been studied in ovarian tumours. The aim of this study was to investigate its expression in ovarian epithelial neoplasms. A total of 195 primary ovarian epithelial borderline or malignant tumours were immunohistochemically studied for the expression of FOXA1...
February 23, 2017: Pathology
https://www.readbyqxmd.com/read/28238417/enhanced-expression-of-programmed-cell-death-1-pd-1-protein-in-benign-vascular-anomalies
#20
Clarissa N Amaya, Frank H Wians, Brad A Bryan, Alireza Torabi
Programmed cell death 1 (PD-1) and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the United States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for treatment of non-small cell lung carcinoma and recently has approved anti-PD-L1 blocker for treatment of metastatic urothelial cell carcinoma. However, the role that the immune system might have on benign tumours including vascular anomalies has received less attention...
February 23, 2017: Pathology
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