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Pathology

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https://www.readbyqxmd.com/read/28822554/malignant-solitary-fibrous-tumour-of-the-kidney-with-lymph-node-and-liver-metastases-beware-of-stat6-expression-in-dedifferentiated-liposarcoma-with-a-solitary-fibrous-tumour-like-morphology
#1
LETTER
https://www.readbyqxmd.com/read/28818465/girdin-protein-expression-is-associated-with-poor-prognosis-in-patients-with-invasive-breast-cancer
#2
Jong-Sun Choi, Kyung Hee Kim, Ensel Oh, Young Kee Shin, Jinwon Seo, Seok-Hyung Kim, Sarah Park, Yoon-La Choi
Girdin is an actin-binding Akt substrate that is an integral component of the PI3K/Akt signalling pathway. However, the clinicopathological significance of Girdin expression in breast cancer has not been clarified. The purpose of this study was to characterise the clinicopathological implication of Girdin expression in breast cancer. Immunohistochemistry-based protein expression analyses of 892 human breast cancer tissues showed that Girdin was expressed in 289 (32.4%) cases. Girdin expression was significantly associated with larger tumour size, frequent lymph node invasion, advanced cancer stage, and expression of oestrogen and progesterone receptors...
August 14, 2017: Pathology
https://www.readbyqxmd.com/read/28811084/low-tumour-cell-content-in-a-lung-tumour-bank-implications-for-molecular-characterisation
#3
Felicia Goh, Edwina E Duhig, Belinda E Clarke, Elizabeth McCaul, Linda Passmore, Deborah Courtney, Morgan Windsor, Rishendren Naidoo, Louise Franz, Kylie Parsonson, Ian A Yang, Rayleen V Bowman, Kwun M Fong
Lung cancer encompasses multiple malignant epithelial tumour types, each with specific targetable, potentially actionable mutations, such that precision management mandates accurate tumour typing. Molecular characterisation studies require high tumour cell content and low necrosis content, yet lung cancers are frequently a heterogeneous mixture of tumour and stromal cells. We hypothesised that there may be systematic differences in tumour cell content according to histological subtype, and that this may have implications for tumour banks as a resource for comprehensive molecular characterisation studies in lung cancer...
August 12, 2017: Pathology
https://www.readbyqxmd.com/read/28811083/phenotypic-chlorhexidine-and-triclosan-susceptibility-in-clinical-staphylococcus-aureus-isolates-in-australia
#4
C Hughes, J Ferguson
Antiseptics such as chlorhexidine gluconate and triclosan are widely used in healthcare settings for both skin antisepsis and decolonisation of Staphylococcus aureus. We determined the minimum inhibitory concentration (MIC) of 198 methicillin susceptible and resistant Staphylococcus aureus clinical isolates to both chlorhexidine and triclosan using an agar dilution method. Of these, 10% (19/198) showed a raised MIC to chlorhexidine and 3% (6/198) showed an elevated MIC to triclosan. The multilocus sequence type (MLST) of each isolate was predicted using a binary method, and although ST93-MRSA-IV was the most common, ST22-MRSA-IV was shown to have statistically higher chlorhexidine MIC values compared with non ST22-MRSA-IV isolates (z = -8...
August 12, 2017: Pathology
https://www.readbyqxmd.com/read/28811082/correlation-between-molecular-analysis-diagnosis-according-to-the-2015-who-classification-of-unresected-lung-tumours-and-ttf1-expression-in-small-biopsies-and-cytology-specimens-from-344-non-small-cell-lung-carcinoma-patients
#5
Prudence A Russell, Toni-Maree Rogers, Benjamin Solomon, Naveed Alam, Stephen A Barnett, Vivek Rathi, Richard A Williams, Gavin M Wright, Matthew Conron
We investigated correlations between diagnosis according to the 2015 World Health Organization (WHO) classification of unresected lung tumours, molecular analysis and TTF1 expression in small biopsy and cytology specimens from 344 non-small cell lung carcinoma (NSCLC) patients. One case failed testing for EGFR, KRAS and ALK abnormalities and six had insufficient tumour for ALK testing. Overall mutation rate in 343 cases was 48% for the genes tested, with 19% EGFR, 33% KRAS and 4% BRAF mutations, and 5% ALK rearrangements detected...
August 12, 2017: Pathology
https://www.readbyqxmd.com/read/28705348/-aussie-normals-an-a-priori-study-to-develop-reference-intervals-in-a-healthy-australian-population-using-the-beckman-coulter-lh-750-haematology-analyser-as-candidates-for-harmonised-values
#6
G Koerbin, J M Potter, K Andriolo, N P West, N Glasgow, C Hawkins, J A Cavanaugh, P E Hickman
Reference limits or intervals are important benchmarks or tools that help the clinician to distinguish between a result that is most likely to lie within a 'healthy' or diseased category. It has been suggested that a review of haematology reference intervals is long overdue. In this study we report on our findings for analytes routinely measured in a complete blood count (CBC) performed on the Beckman Coulter LH 750 analyser and an additional comparative study using the Beckman Coulter LH 750, the Sysmex XN and Abbott Sapphire...
August 2017: Pathology
https://www.readbyqxmd.com/read/28705347/loss-of-bap1-expression-is-very-rare-in-breast-carcinoma
#7
LETTER
Jeanie Chui, Arjun Singh, Anthony J Gill
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28693750/idelalisib-induced-cmv-gastrointestinal-disease-the-need-for-vigilance-with-novel-therapies
#8
LETTER
Lorena Goldring, Beena Kumar, T Eng Gan, Michael Sze Yuan Low
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28693749/primary-gastrointestinal-anaplastic-large-cell-lymphoma
#9
Yi-Ying Lee, Katsuyoshi Takata, Ren-Ching Wang, Sheau-Fang Yang, Shih-Sung Chuang
Primary gastrointestinal anaplastic large cell lymphoma (GI-ALCL) is rare. We report eight new cases. The median age was 61.5 years (range 10-88), most frequently involving the stomach (n = 3) and small intestine (n = 4). The neoplastic hallmark cells in all cases expressed CD30. Anaplastic lymphoma kinase (ALK) protein was expressed in two cases (25%). By in situ hybridisation, all cases were negative for Epstein-Barr virus and for DUSP22/IRF4 gene translocation. At a median follow-up time of 37.5 months, four patients died of disease, one was alive with disease, and three were disease-free...
August 2017: Pathology
https://www.readbyqxmd.com/read/28693748/mixed-mucinous-adenocarcinoma-and-somatostatinoma-of-the-ampulla-of-vater-associated-with-neurofibromatosis-type-1
#10
LETTER
Róisín Reynolds, Veli Marjoniemi
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28693747/germline-bap1-mutations-also-predispose-to-cutaneous-squamous-cell-carcinoma
#11
LETTER
Robert V Rawson, Geoffrey F Watson, Annabelle M Maher, Stanley W McCarthy, John F Thompson, Richard A Scolyer
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28689635/extrauterine-peritoneal-placental-site-nodule
#12
LETTER
Caroline Kurek, Richard Jaworski, Vince Lamaro
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28689634/impact-of-the-australian-gender-specific-thresholds-using-the-abbott-high-sensitivity-troponin-i-assay-in-clinical-care
#13
Robert Bender, Faith Njue, Samuel Vasikaran, Ramon Lambert, Jamie Rankin, Graham S Hillis, Damon A Bell
The aim of this study was to ascertain the impact of gender specific hs-TnI thresholds in a clinical setting and determine the clinical characteristics and discharge diagnosis for individuals presenting to the Emergency Department (ED) with elevated troponin I with the Abbott high-sensitivity troponin I (hs-TnI) assay, but non-elevated troponin I on the previous generation assay (STAT TnI-II). Medical records of individuals presenting to the Royal Perth Hospital ED with elevated hs-TnI between 12 November 2013 and 24 December 2013 were retrospectively reviewed...
August 2017: Pathology
https://www.readbyqxmd.com/read/28689633/follicular-lymphoma-with-hyaline-vascular-castleman-disease-like-follicles-and-cd20-positive-follicular-dendritic-cells
#14
LETTER
Sergio Pina-Oviedo, Wei Wang, Erin Vicknair, John T Manning, L Jeffrey Medeiros
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28689632/foreign-body-ileitis-a-histopathological-mimic-of-crohn-s-disease
#15
LETTER
Sailakshmi Krishnan, Tony Dill, David Simons, Hui Yin
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28689631/vasculogenic-mimicry-in%C3%A2-vitro-in-tumour-cells-derived-from-metastatic-malignant-pleural-effusions
#16
LETTER
Francesca Sasanelli, Ashleigh Hocking, Emily Pulford, Yazad Irani, Sonja Klebe
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28688724/pd-1-and-pd-l1-expression-in-bone-and-soft-tissue-sarcomas
#17
Alireza Torabi, Clarissa N Amaya, Frank H Wians, Brad A Bryan
PD-1 and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the Unites States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for treatment of non-small cell lung carcinoma and recently expanded the use of immunotherapy for metastatic urothelial cell carcinoma and Hodgkin lymphoma. However, studies on expression of PD-1 and its ligand in malignant bone and soft tissue sarcoma are sparse. In this study, we evaluated PD-1 and PD-L1 expression on variants of liposarcomas and rhabdomyosarcomas, osteosarcomas and chondrosarcomas...
August 2017: Pathology
https://www.readbyqxmd.com/read/28673429/a-novel-fibrinogen-gamma-chain-mutation-c-1096c-g-p-his340asp-fibrinogen-ankara-causing-hypofibrinogenaemia-and-hepatic-storage
#18
LETTER
Francesco Callea, Isabella Giovannoni, Sinan Sari, Aysel Unlusoy Aksu, Guldal Esendagly, Buket Dalgic, Renata Boldrini, Gulen Akyol, Paola Francalanci, Emanuele Bellacchio
No abstract text is available yet for this article.
August 2017: Pathology
https://www.readbyqxmd.com/read/28673428/indolent-t-cell-lymphoproliferative-disease-of-the-gastrointestinal-tract-in-a-renal-transplant-patient-diagnostic-pitfalls-and-clinical-challenges
#19
LETTER
https://www.readbyqxmd.com/read/28673427/linear-variant-of-large-plaque-type-blue-naevus-with-subcutaneous-cellular-nodules
#20
LETTER
Cyril Habougit, Dominique Michiels-Marzais, Qing Wang, Daniel Pissaloux, Arnaud de la Fouchardiere
No abstract text is available yet for this article.
August 2017: Pathology
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