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https://www.readbyqxmd.com/read/29050846/zika-virus-what-where-from-and-where-to
#1
REVIEW
Kerri Basile, Jen Kok, Dominic E Dwyer
The significance of Zika virus as a clinically significant flavivirus has previously been under-recognised, until extensive outbreaks in Yap in 2007, French Polynesia in 2013 and the Americas since 2015. Although Zika virus infection is commonly asymptomatic or mild, emerging evidence suggests a strong link to microcephaly in babies and Guillain-Barré syndrome in adults. This article reviews the epidemiology, geographic distribution, basic virology, transmission, clinical presentation, potential complications, laboratory diagnosis, treatment and prevention of Zika virus infection...
October 16, 2017: Pathology
https://www.readbyqxmd.com/read/29046226/pertussis-toxin-iga-testing-over-diagnoses-recent-pertussis-infection
#2
Meryta L May, Jenny Evans, Thomas Holgate, Suhail A Doi, Paul Ross, Jennifer M Robson
The importance of pertussis toxin (PT) IgA testing in the diagnosis of recent pertussis infection remains unclear. The contribution of PT IgA to the diagnosis of recent pertussis was reviewed in two separate analyses. Firstly, an evaluation of two new automated assays [DiaSorin Liaison (DL), Italy] for PT IgG and PT IgA provided an opportunity to assess the contribution of PT IgA testing to PT IgG results. Secondly, a retrospective review of results from the PT IgA assay currently in use [Sullivan Nicolaides Pathology (SNP) PT IgA] was performed from 2013 to 2015 (n=63,474)...
October 15, 2017: Pathology
https://www.readbyqxmd.com/read/29037804/fluorescence-in-situ-hybridisation-as-an-ancillary-tool-in-the-diagnosis-of-acral-melanoma-a-review-of-44-cases
#3
Jing Su, Wenjuan Yu, Jianying Liu, Jie Zheng, Sixia Huang, Yuchen Wang, Shuangshuang Qi, Xiaolong Ma, Jian Chen, Yan Zhang
Acral melanoma is associated with outcomes which are more unfavourable than those of other melanoma subtypes, and acral melanoma has higher mortality. However, histological distinction of acral melanoma from acral naevi may be difficult. Fluorescence in situ hybridisation (FISH) targeting specific genes has been used as an ancillary method for differential diagnosis of melanocytic tumours, but most previous studies have focused on non-acral lesions which may have genetic alterations different from acral lesions...
October 13, 2017: Pathology
https://www.readbyqxmd.com/read/29037803/prognostic-significance-and-biopsy-characteristics-of-prostate-cancer-with-seminal-vesicle-invasion-on-radical-prostatectomy-a-nationwide-population-based-study
#4
Anna Kristiansen, Linda Drevin, Brett Delahunt, Hemamali Samaratunga, David Robinson, Ingela Franck Lissbrant, Pär Stattin, Lars Egevad
The objective of this study was to evaluate the prognostic significance of seminal vesicle invasion (SVI, pT3b) compared with extraprostatic extension (EPE) alone (pT3a) after radical prostatectomy, and to correlate pre-operative biopsy pathology with SVI and EPE. The National Prostate Cancer Register includes all prostate cancers diagnosed in Sweden. We analysed 4063 cases with stage category pT3a and 1371 cases with pT3b at radical prostatectomy between 2000 and 2012. Associations between pT3a and pT3b and progression were evaluated and adjusted for year, age, biopsy grade and s-PSA...
October 13, 2017: Pathology
https://www.readbyqxmd.com/read/29021100/the-value-of-endomyocardial-biopsy-in-diagnosis-and-guiding-therapy
#5
Tayyaba Khan, Dinesh Selvakumar, Siddharth Trivedi, Karan Rao, Mehmet Harapoz, Aravinda Thiagalingam, A Robert Denniss, Winny Varikatt
Endomyocardial biopsy (EMB) is a highly-specialised procedure that is associated with some controversy as to its diagnostic role due to its inconsistency in diagnosing a wide variety of cardiac diseases. Given the advances and sophistication in echocardiography and cardiac magnetic resonance imaging (MRI), the vast majority of cardiac diseases can be diagnosed by these non-invasive procedures. Under-sampling and the fact that biopsy site is limited to the right side of the interventricular septum further limits its value...
October 8, 2017: Pathology
https://www.readbyqxmd.com/read/29017720/insights-into-the-molecular-roles-of-zika-virus-in-human-reproductive-complications-and-congenital-neuropathologies
#6
REVIEW
Rajendra Gharbaran, Latchman Somenarain
The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor cells (NPCs) of the developing fetus, resulting in changes of brain structures, reminiscent of human microcephaly. In vitro and ex vivo studies using human cells and tissues showed that human NPCs and placental cells are targeted by ZIKV...
October 7, 2017: Pathology
https://www.readbyqxmd.com/read/28950991/the-decline-of-medical-publishing-the-rise-of-the-pseudo-journal
#7
EDITORIAL
Brett Delahunt, Hemamali Samaratunga, Lars Egevad
No abstract text is available yet for this article.
September 23, 2017: Pathology
https://www.readbyqxmd.com/read/28950990/recent-advances-in-the-diagnosis-of-soft-tissue-tumours
#8
REVIEW
Inga-Marie Schaefer, Christopher D M Fletcher
Soft tissue tumours are relatively rare, but are diagnostically challenging as they comprise a large spectrum of diagnostic entities. Substantial advances have been made in recent years in identifying the underlying recurrent chromosomal and genomic alterations in a significant subset of soft tissue tumours, and this continues to enrich our understanding of the biological mechanisms of tumour development and progression. Ongoing validation and integration of these findings into existing pathological-diagnostic algorithms has led to re- or subclassification of diagnostic categories and will continue to shape a more nuanced (and hopefully clinically relevant) tumour classification system in the future...
September 23, 2017: Pathology
https://www.readbyqxmd.com/read/28860049/tests-for-autoimmunity-a-luddite-analysis
#9
EDITORIAL
Myfanwy Spellerberg
No abstract text is available yet for this article.
August 28, 2017: Pathology
https://www.readbyqxmd.com/read/28843919/gene-copy-number-variation-and-protein-overexpression-of-egfr-and-her2-in-distal-extrahepatic-cholangiocarcinoma
#10
Min Jung Jung, Chang Gok Woo, Saetbyeol Lee, Susie Chin, Hee Kyung Kim, Jeong Ja Kwak, Eun Suk Koh, Bora Lee, Kee-Taek Jang, Ahrim Moon
EGFR and HER2 are among the most promising therapeutic targets in solid cancers. The expression status of EGFR and HER2 are associated with the prognosis, and with a number of clinicopathological factors, in many cancers. However, few studies have examined this association in distal extrahepatic cholangiocarcinoma (EHCC). Therefore, we investigated EGFR and HER2 protein expression and gene copy number variation (CNV) in distal EHCC. We also studied the association of these factors with clinicopathological parameters and prognosis...
August 24, 2017: Pathology
https://www.readbyqxmd.com/read/28844339/advances-in-merkel-cell-carcinoma-from-a-pathologist-s-perspective
#11
REVIEW
Sarah Kay Barksdale
Merkel cell carcinoma (MCC) is a rarely made but potentially devastating diagnosis. While local disease might be cured by surgery and radiotherapy, advanced disease is usually rapidly progressive and fatal. Until very recently, the only approach to metastatic MCC was cytotoxic chemotherapy with results so disappointing that current treatment guidelines discourage its use and recommend clinical trial as a more viable treatment option. Fortunately, recent advances in the understanding of the molecular pathogenesis of this tumour have produced a wide variety of experimental treatments for MCC, some of which are quite promising...
August 22, 2017: Pathology
https://www.readbyqxmd.com/read/28838615/malignant-solitary-fibrous-tumour-of-the-kidney-with-lymph-node-and-liver-metastases-beware-of-stat6-expression-in-dedifferentiated-liposarcoma-with-a-solitary-fibrous-tumour-like-morphology-author-reply
#12
LETTER
Yu Yang, Catherine R Miller, Cecilia Clement, Ondrej Hes, Eduardo Eyzaguirre
No abstract text is available yet for this article.
August 21, 2017: Pathology
https://www.readbyqxmd.com/read/28830691/high-grade-adenocarcinoma-in-the-ectopic-prostate-accompanied-by-a-low-grade-adenocarcinoma-in-the-orthotopic-prostate-an-unusual-diagnostic-pitfall
#13
LETTER
Yuri Tolkach, Jörg Ellinger, Stefan Müller, Glen Kristiansen
No abstract text is available yet for this article.
August 19, 2017: Pathology
https://www.readbyqxmd.com/read/28830690/interdigitating-dendritic-cell-sarcoma-diagnostic-pitfalls-treatment-challenges-and-role-of-transdifferentation-in-pathogenesis
#14
LETTER
Slavisa Ninkovic, Merrole F Cole-Sinclair
No abstract text is available yet for this article.
August 19, 2017: Pathology
https://www.readbyqxmd.com/read/28830689/clinicopathological-and-molecular-stability-and-methylation-analyses-of-gastric-papillary-adenocarcinoma
#15
Noriyuki Uesugi, Tamotsu Sugai, Ryo Sugimoto, Makoto Eizuka, Yasuko Fujita, Ayaka Sato, Mitsumasa Osakabe, Kazuyuki Ishida, Keisuke Koeda, Akira Sasaki, Takayuki Matsumoto
The molecular alterations and pathological features of gastric papillary adenocarcinoma (GPA) remain unknown. We examined GPA samples and compared their molecular and pathological characteristics with those of gastric tubular adenocarcinoma (GTA). Additionally, we identified pathological and molecular features of GPA that vary with microsatellite stability. In the present study, samples from 63 GPA patients and 47 GTA patients were examined using a combination of polymerase chain reaction (PCR)-microsatellite assays and PCR-pyrosequencing in order to detect microsatellite instability (microsatellite instability, MSI; microsatellite stable, MSS), methylation status (low methylation, intermediate methylation and high methylation level), and chromosomal AI in multiple cancer-related loci...
August 19, 2017: Pathology
https://www.readbyqxmd.com/read/28830688/non-linear-optical-imaging-and-quantitative-analysis-of-the-pathological-changes-in-normal-and-carcinomatous-human-colorectal-muscularis
#16
Guowei Xia, Weijia Zhi, Yong Zou, Lifeng Wang, Changzhen Wang, Ruiyun Peng, Xiangjun Hu
Non-linear optical (NLO) imaging based on two-photon excitation (2PE) and second harmonic generation (SHG) has been widely used to image microstructures of biomedical specimens over the last two decades. We employed NLO imaging technology to investigate the histology of normal and carcinomatous human colorectal muscularis in transverse and longitudinal views. Results show there are different patterns of pathological changes of muscularis in tissue structure and cell morphology from both views. The NLO imaging provides identical histological information as the H&E images but requires neither stain nor tissue processing...
August 19, 2017: Pathology
https://www.readbyqxmd.com/read/28826836/new-immunoassays-for-anti-hmg-coa-reductase-antibodies-may-lead-to-incorrect-diagnosis-in-inflammatory-myositis
#17
LETTER
Luke Droney, David Gillis, Richard Wong
No abstract text is available yet for this article.
August 18, 2017: Pathology
https://www.readbyqxmd.com/read/28826835/adenoid-cystic-carcinoma-with-lipometaplasia-a-case-report-with-morphoproteomic-analysis-of-lipogenesis
#18
LETTER
Byeong-Joo Noh, Youn Wha Kim, Yong-Koo Park, Juhie Lee
No abstract text is available yet for this article.
August 18, 2017: Pathology
https://www.readbyqxmd.com/read/28826834/primary-splenic-low-grade-follicular-lymphoma-presenting-with-leukaemia-and-large-cell-transformation-in-the-marrow
#19
LETTER
Jie-Yang Jhuang, Yen-Chuan Hsieh, Chun-Chi Kuo, Ying-Zhen Su, Shih-Sung Chuang
No abstract text is available yet for this article.
August 18, 2017: Pathology
https://www.readbyqxmd.com/read/28826833/systemic-mastocytosis-associated-with-acute-myeloid-leukaemia
#20
LETTER
Min Jong Kim, Min Kyoung Kim, Yu Kyung Kim, Mi Jin Gu
No abstract text is available yet for this article.
August 18, 2017: Pathology
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