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Pathology

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https://www.readbyqxmd.com/read/28549721/comparison-of-enzyme-linked-immunosorbent-assay-and-rapid-chemiluminescent-analyser-in-the-detection-of-myeloperoxidase-and-proteinase-3-autoantibodies
#1
Phillippa A Pucar, Carolyn A Hawkins, Katrina L Randall, Candice Li, Euan McNaughton, Matthew C Cook
Antibodies to myeloperoxidase (MPO) and proteinase 3 (PR3) are vital in the diagnosis and management of ANCA-associated vasculitis. A chemiluminescent immunoassay (CLIA; Quanta Flash) provides MPO and PR3 antibody results in 30 minutes, which is much faster than enzyme-linked immunosorbent assay (ELISA). We compared the performance of ELISA (Orgentec) and CLIA (Quanta Flash) for MPO and PR3 antibody quantitation on 303 samples, comprising 196 consecutive samples received in a single diagnostic laboratory over a 3 month period, and 107 samples collected from 42 known vasculitis patients over a 40 month period...
June 2017: Pathology
https://www.readbyqxmd.com/read/28495175/a-case-of-ureteric-polypoid-endometriosis-presenting-in-a-post-menopausal-woman
#2
LETTER
Liqing Zhuang, David Eisinger, Richard Jaworski
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28483372/role-of-plasma-cells-in-waldenstr%C3%A3-m-macroglobulinaemia
#3
REVIEW
Ali El-Ayoubi, James Q Wang, Nadine Hein, Dipti Talaulikar
Waldenström macroglobulinaemia (WM) is an indolent mature B cell lymphoma characterised by an infiltrate of heterogeneous B cells and hypersecretion of IgM. There are two distinct cellular populations that can be distinguished on morphology and immunophenotyping within the bone marrow. The predominant lymphoplasmacytic compartment arises at an earlier stage in ontogeny, and is responsible for the cytopenias noted during the symptomatic phase of the disease. This population is ably targeted by B cell immunodepletion...
June 2017: Pathology
https://www.readbyqxmd.com/read/28454994/molecular-masquerading-of-rare-egfr-l858m-l861r-mutations-as-common-l858r-l861q-mutations-by-pna-clamping-assay
#4
LETTER
Ji Hyung Hong, Seung-Hyun Jung, Min Sung Kim, Sug Hyung Lee, Yeun-Jun Chung
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28450092/primary-renal-sclerosing-epithelioid-fibrosarcoma-a-case-report-and-review-of-the-literature
#5
LETTER
Alireza Torabi, Javier Corral, Zoran Gatalica, Jeff Swensen, Shayan Moraveji, Julia A Bridge
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28450091/pd-l1-and-notch1-expression-in-kshv-hhv-8-and-ebv-associated-germinotropic-lymphoproliferative-disorder-case-report-and-review-of-the-literature
#6
LETTER
Arash Ronaghy, Huan-You Wang, John A Thorson, L Jeffrey Medeiros, Yi Xie, Xinmin Zhang, Silvat Sheikh-Fayyaz
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28450090/malignant-solitary-fibrous-tumour-of-the-kidney-with-lymph-node-and-liver-metastases
#7
LETTER
Yu Yang, Catherine R Miller, Cecilia Clement, Ondrej Hes, Eduardo Eyzaguirre
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28450089/gram-negative-resistance-in-community-urine-isolates
#8
LETTER
Kyra Y L Chua, Mina Grais
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28450088/non-brca-familial-breast-cancer-review-of-reported-pathology-and-molecular-findings
#9
Michael G Keeney, Fergus J Couch, Daniel W Visscher, Noralane M Lindor
The majority of women evaluated for a clinical concern of possible hereditary breast cancer syndromes have no identified pathogenic variants in genes predisposing them to breast cancer. Non-BRCA1- or BRCA2-related familial breast cancer, also called 'BRCAX', thus comprises a sizeable proportion of familial breast cancer but it is poorly understood. In this study, we reviewed 14 studies on histopathology and molecular studies of BRCAX to determine if there were differences between 'sporadic' breast cancers and compared to cancers arising in women harbouring variants in known cancer predisposition genes...
June 2017: Pathology
https://www.readbyqxmd.com/read/28450087/validity-and-reliability-of-ki-67-assessment-in-oestrogen-receptor-positive-breast-cancer
#10
Nicola Jing, Catherine Fang, David S Williams
Ki-67 is a prognostic and predictive biomarker in oestrogen receptor positive breast cancer. However, its measurement is not well standardised. This study compared the validity, intra- and inter-observer reproducibility and reporting time of five methods of Ki-67 assessment on tissue microarrays (TMA) and whole slides. Ki-67 labelling index (LI) was assessed on 71 breast carcinomas of no special type (NST), using five methods: manual counting (gold standard), unaided visual estimation, visual estimation aided by reference photographs, semi-manual digital image analysis (DIA) and fully automated DIA (Aperio platform)...
June 2017: Pathology
https://www.readbyqxmd.com/read/28450086/kras-mutation-testing-on-all-non-malignant-diagnosis-of-pancreatic-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsies-improves-diagnostic-accuracy
#11
Elena Trisolini, Elia Armellini, Alessia Paganotti, Claudia Veggiani, Cristina Bozzola, Milo Frattini, Corinna Pizio, Giuseppe Mancuso, Silvano Andorno, Renzo Boldorini
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the procedure of choice for the cytologic diagnosis of pancreatic masses. The specificity of EUS-FNA approaches 100%, but the sensitivity is still low, and the high rate of indeterminate (atypical and suspicious) and false-negative results needs improvement. KRAS gene is frequently mutated in pancreatic ductal adenocarcinoma (PDAC) (up to 90%), and mutation analysis of KRAS has been proposed as diagnostic biomarker of PDAC. In most laboratories, KRAS mutation testing is performed by Sanger sequencing or real time-quantitative polymerase chain reaction (RT-qPCR), but these methods may give false-negative results in routine samples, mainly due to low cellularity...
June 2017: Pathology
https://www.readbyqxmd.com/read/28446364/clinical-and-laboratory-diagnosis-of-heparin-induced-thrombocytopenia-an-update
#12
REVIEW
Emmanuel J Favaloro, Georgia McCaughan, Leonardo Pasalic
Heparin remains a commonly used anticoagulant in prophylaxis and treatment of venous and arterial thrombosis, in addition to ensuring patency of artificial blood circuits such as cardiopulmonary bypass (CPB). Heparin induced thrombocytopenia (HIT) is a rare but potentially fatal complication of heparin therapy that results from production of polyclonal antibodies to heparin in complex, usually with platelet factor 4 (PF4). In a proportion of patients, this causes platelet activation and thrombin generation, which may result in thrombosis...
June 2017: Pathology
https://www.readbyqxmd.com/read/28446363/reassessment-of-lipaemic-index-threshold-triggering-high-speed-centrifugation-of-lipaemic-specimens
#13
LETTER
Marie M Salib, Carmen Oakman, Aaron J Simpson, Peter E Hickman, Julia M Potter
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28446362/ovarian-haemangiomas-with-peripheral-hilus-cell-proliferation
#14
LETTER
Mudiwa Muronda, Peter Russell, Jill Griffith, Felix Chan, Peter Bell, Imad Mahmoud
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28442140/cystic-neutrophilic-granulomatous-mastitis-associated-with-corynebacterium-including-corynebacterium-kroppenstedtii
#15
Kate J Johnstone, Jennifer Robson, Sarah G Cherian, Jenny Wan Sai Cheong, Kris Kerr, Judith F Bligh
Granulomatous (lobular) mastitis is a rare inflammatory breast disease affecting parous reproductive-aged women. Once considered idiopathic, there is growing evidence of an association with corynebacteria infection, especially in the setting of a distinct histological pattern termed cystic neutrophilic granulomatous mastitis (CNGM). We describe 15 cases with histological features either confirming (n = 12) or suggesting (n = 3) CNGM, and concurrent microbiological evidence of Corynebacterium species. The organism was detected by culture or 16S rRNA gene sequencing of specimens obtained at surgery or fine needle aspiration...
June 2017: Pathology
https://www.readbyqxmd.com/read/28438394/gastric-foveolar-dysplasia-a-survey-of-reporting-habits-and-diagnostic-criteria
#16
Stefano Serra, Rola Ali, Adrian C Bateman, Kaushik Dasgupta, Vikram Deshpande, David K Driman, David Gibbons, Andrea Grin, Sara Hafezi-Bakhtiari, Kieran Sheahan, Amitabh Srivastava, Eva Szentgyorgyi, Rajkumar Vajpeyi, Shaun Walsh, Lai Mun Wang, Runjan Chetty
This study aimed to ascertain views, incidence of reporting and diagnostic criteria for gastric foveolar dysplasia. A questionnaire, a post-questionnaire discussion and microscopic assessment of selected cases was conducted by gastrointestinal pathologists to explore the above-stated aims. Fifty-four percent of respondents never or rarely diagnosed gastric foveolar-type dysplasia. The general consensus was that round nuclei, lack of nuclear stratification, presence of inflammation/damage and surface maturation favoured reactive change; while architectural abnormalities/complexity and nuclear enlargement mainly were used to separate low-grade from high-grade foveolar dysplasia...
June 2017: Pathology
https://www.readbyqxmd.com/read/28438393/use-of-the-entericbio-gastro-panel-ii-in-a-diagnostic-microbiology-laboratory-challenges-and-opportunities
#17
Gary McAuliffe, Liselle Bissessor, Deborah Williamson, Sharon Moore, Janet Wilson, Muriel Dufour, Susan Taylor, Arlo Upton
We sought to verify the performance of the EntericBio real-time Gastro Panel 2 (GP2; Serosep, Ireland) assay targeting Salmonella, Shigella, Campylobacter, verotoxin producing E. coli (VTEC), Giardia, and Cryptosporidium in a high-throughput diagnostic laboratory. Following a technical verification period where 237 faecal samples were tested in parallel, guided culture and discrepancy analysis were performed. A total of 13,223 faecal samples were screened by the GP2 assay. During technical verification, sensitivity, specificity, negative and positive predictive value of the GP2 assay compared with conventional methods were 100% (83-100%), 98% (96...
June 2017: Pathology
https://www.readbyqxmd.com/read/28438392/immunohistochemical-detection-of-pd-l1-for-research-studies-which-antibody-and-what-protocol
#18
LETTER
Chidozie C Anyaegbu, Kerryn Garrett, Chris Hemmings, Tracey F Lee-Pullen, Melanie J McCoy
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28438391/myoid-neoplasm-with-lipoblast-like-cells-and-haemangiopericytoma-pattern-an-unusual-manifestation-of-ebv-associated-myoid-tumour
#19
LETTER
Shaun Kian Hong Cheng, Wai Ming Yap, Khoon Leong Chuah
No abstract text is available yet for this article.
June 2017: Pathology
https://www.readbyqxmd.com/read/28438390/anaemia-and-triple-negative-bone-marrow-fibrosis-a-diagnostic-conundrum
#20
LETTER
Prasad R Koduri
No abstract text is available yet for this article.
June 2017: Pathology
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