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European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes

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https://www.readbyqxmd.com/read/27884008/left-ventricular-plication-reduces-wall-stress-and-cardiomyocyte-hypertrophy-in-a-rat-model-of-ischemic-cardiomyopathy
#1
Hidetsugu Asai, Yasushige Shingu, Tomoji Yamakawa, Haruki Niwano, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
BACKGROUND: The indications of left-ventricular plication (LVP) are controversial, although several studies have reported favorable outcomes in heart failure patients. The aim of this study was to assess left-ventricular (LV) wall stress and myocardial remodeling after LVP in a rat model of myocardial infarction (MI). METHODS: Sixteen rats underwent LVP by excluding the LV anterior wall scar 4 weeks after ligation of the left anterior descending artery. After 4 weeks, LV wall stress was assessed using transthoracic echocardiography and an LV catheter...
November 25, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27838689/delivery-of-soluble-heme-oxygenase-1-cell-penetrating-peptide-into-liver-cells-in-in-vitro-and-ex-vivo-models-of-cold-ischemia
#2
Ananda Baskaran Venkatachalam, Scott Michael Livingstone, Qianni Hu, Ayush Ray, Caroline Wood, Sanem Cimen, Ian Patrick Joseph Alwayn
BACKGROUND/PURPOSE: Liver transplantation is the treatment of choice in patients with end-stage liver disease. During liver transplantation, ischemia-reperfusion injury (IRI) occurs, which is an inevitable consequence of the transplantation process. To reduce the extent of cellular injury, one of the proteins that have been extensively investigated is heme oxygenase 1 (HO-1), which plays an important role in protecting the organs against IRI. The aim of this study was to introduce an active and functional HO-1 protein conjugated to a cell-penetrating peptide (CPP) in vitro and ex vivo into liver cells in hypothermic and anoxic conditions and to assert its cytoprotective effects...
November 12, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27658312/diffuse-reflectance-spectroscopy-for-surface-measurement-of-liver-pathology
#3
Jan H Nilsson, Nina Reistad, Hannes Brange, Carl-Fredrik Öberg, Christian Sturesson
BACKGROUND: Liver parenchymal injuries such as steatosis, steatohepatitis, fibrosis, and sinusoidal obstruction syndrome can lead to increased morbidity and liver failure after liver resection. Diffuse reflectance spectroscopy (DRS) is an optical measuring method that is fast, convenient, and established. DRS has previously been used on the liver with an invasive technique consisting of a needle that is inserted into the parenchyma. We developed a DRS system with a hand-held probe that is applied to the liver surface...
September 23, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27598993/mesenchymal-stem-cells-contribute-to-hepatic-maturation-of-human-induced-pluripotent-stem-cells
#4
Chisato Takagi, Hiroshi Yagi, Makiko Hieda, Kazuki Tajima, Taizo Hibi, Yuta Abe, Minoru Kitago, Masahiro Shinoda, Osamu Itano, Yuko Kitagawa
BACKGROUND: Induced pluripotent stem cells (iPSCs) are human somatic cells that have been reprogrammed to a pluripotent state. Several methods have been used to generate hepatocyte-like cells from iPSCs. However, these hepatic cells have limited clinical application because of their immature function compared to primary hepatocytes. Mesenchymal stem cells (MSCs) have been reported to inhibit apoptosis of hepatic cells and to improve hepatic regeneration in acute liver injury. Therefore, we expected that MSCs had the potential to positively contribute to the maturation of hepatic cells...
September 7, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27583458/20th-surgical-research-days-section-of-surgical-research-of-the-german-society-of-surgery-september-8-10-2016-magdeburg-germany-abstracts
#5
(no author information available yet)
No abstract text is available yet for this article.
September 2, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27577554/initial-resistance-of-carina-anastomoses-with-increasing-tensile-stress-an-ex-vivo-model-comparing-different-suture-techniques
#6
Andreas Kirschbaum, Stefanie Hemmerling, Thorsten Steinfeldt, Detlef K Bartsch, Nikolas Mirow
BACKGROUND: After resection of the carina with a length of more than 4 cm, anastomoses often need to be performed under tension despite maximum mobilization. If the patient cannot be extubated, the anastomosis remains under continued stress. Anastomoses of the carina can be constructed using various suture techniques, including single interrupted sutures, back wall running but front wall single interrupted sutures, and complete running suture. This experimental study was designed to determine the most tensile stress-resistant anastomotic suture technique...
August 31, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27577699/uniformity-of-chronic-pain-assessment-after-inguinal-hernia-repair-a-critical-review-of-the-literature
#7
Marijke Molegraaf, Johan Lange, Arthur Wijsmuller
BACKGROUND: Chronic postoperative inguinal pain (CPIP) is the most common long-term complication of inguinal hernia repair. As such procedures are routinely performed, CPIP can be considered a significant burden to global health care. Therefore, adequate preventative measures relevant to surgical practice are investigated. However, as no gold standard research approach is currently available, study and outcome measures differ between studies. The current review aims to provide a qualitative analysis of the literature to seek out if outcomes of CPIP are valid and comparable, facilitating recommendations on the best approach to preventing CPIP...
August 27, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27560977/argon-preconditioning-protects-airway-epithelial-cells-against-hydrogen-peroxide-induced-oxidative-stress
#8
Christina Hafner, Hong Qi, Lourdes Soto-Gonzalez, Katharina Doerr, Roman Ullrich, Eva Verena Tretter, Klaus Markstaller, Klaus Ulrich Klein
BACKGROUND: Oxidative stress is the predominant pathogenic mechanism of ischaemia-reperfusion (IR) injury. The noble gas argon has been shown to alleviate oxidative stress-related myocardial and cerebral injury. The risk of lung IR injury is increased in some major surgeries, reducing clinical outcome. However, no study has examined the lung-protective efficacy of argon preconditioning. The present study investigated the protective effects of argon preconditioning on airway epithelial cells exposed to hydrogen peroxide (H2O2) to induce oxidative stress...
August 25, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27544776/development-of-a-vascularized-heterotopic-neonatal-rat-heart-transplantation-model
#9
Shogo Shimada, Pedro J Del Nido, Ingeborg Friehs
BACKGROUND/PURPOSE: Rodent adult-to-adult heterotopic heart transplantation is a well-established animal model, and the detailed surgical technique with several modifications has been previously described. In immature donor organ transplantation, however, the surgical technique needs to be revised given the smaller size and fragility of the donor graft. Here, we report our surgical technique for heterotopic abdominal (AHTx) and femoral (FHTx) neonatal rat heart transplantation based on an experience of over 300 cases...
August 20, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27459202/bioengineered-livers-a-new-tool-for-drug-testing-and-a-promising-solution-to-meet-the-growing-demand-for-donor-organs
#10
Franziska Mußbach, Utz Settmacher, Olaf Dirsch, Chichi Xie, Uta Dahmen
BACKGROUND: Organ engineering is a new innovative strategy to cope with two problems: the need for physiological models for pharmacological research and donor organs for transplantation. A functional scaffold is generated from explanted organs by removing all cells (decellularization) by perfusing the organ with ionic or nonionic detergents via the vascular system. Subsequently the acellular scaffold is reseeded with organ-specific cells (repopulation) to generate a functional organ. SUMMARY: This review gives an overview of the state of the art describing the decellularization process, the subsequent quality assessment, the repopulation techniques and the functional assessment...
July 27, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27441690/antinociceptive-effects-of-ginsenoside-rg3-in-a-rat-model-of-incisional-pain
#11
Eun Jin Ahn, Geun Joo Choi, Hyun Kang, Chong Wha Baek, Yong Hun Jung, Young Cheol Woo, Si Ra Bang
BACKGROUND: Ginsenoside Rg3 is an extract of total ginseng saponins, which accounts for 4.7% of all saponins. This study aimed to identify the mechanisms of the antinociceptive effects of ginsenoside Rg3. METHODS: Rats were randomly divided into six groups, which were treated with vehicle or 0.5, 1, 1.5, 2, or 4 mg/kg of ginsenoside Rg3 intraperitoneally 2 h after a plantar incision was made. To evaluate the mechanisms of antinociceptive effects, the rats were intraperitoneally injected with naloxone 5 mg/kg, atropine 1 mg/kg, yohimbine 2 mg/kg, mecamylamine 1 mg/kg, prazosin 1 mg/kg, and dexmedetomidine 5 μg/kg...
July 22, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27441643/immune-architecture-of-colorectal-lung-metastases-and-implications-for-patient-survival
#12
Stefan M Brunner, Ulrich Hahn, Tonia Jeiter, Rebecca Kesselring, Christoph Rubner, Petra Ruemmele, Zsolt Sziklavari, Hans S Hofmann, Hans J Schlitt, Stefan Fichtner-Feigl
BACKGROUND: Pulmonary metastases occur in 10-20% of patients with colorectal cancer and significantly influence long-term survival. In this study, the immunological architecture of colorectal lung in comparison to liver metastases and its impact on patient survival were examined. METHODS: Specimens of patients with colorectal lung and liver metastases were stained for HE, CD4, CD8, CD20, CD68 and CD45RO. Besides histomorphological evaluation, immunohistochemical stainings were analyzed for the respective cell numbers separately for tumor area, infiltrative margin and distant lung or liver stroma...
July 22, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27441597/distinct-gene-expression-patterns-defining-human-osteoblasts-response-to-bmp2-treatment-is-the-therapeutic-success-all-a-matter-of-timing
#13
Sabrina Ehnert, Romina Haydée Aspera-Werz, Thomas Freude, Marie Karolina Reumann, Björn Gunnar Ochs, Christian Bahrs, Steffen Schröter, Elke Wintermeyer, Andreas Klaus Nussler, Stefan Pscherer
BACKGROUND: Bone morphogenetic proteins (BMPs) play a key role in bone formation. Local application of BMP2 (Dibotermin alfa) supports bone formation when applied to complex fractures. However, up to 33% of patients do not respond to this therapy. PURPOSE: Aiming to investigate whether inter-individual responses to BMP2 treatment can be predicted by gene expression patterns, we investigated the effect of BMP2 on primary human osteoblasts and THP-1 cell-derived osteoclasts from 110 donors...
July 22, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27434375/limits-of-and-complications-after-embolization-of-the-hepatic-artery-and-portal-vein-to-induce-segmental-hypertrophy-of-the-liver-a-large-mini-pig-study
#14
Nils Heits, Lars Mueller, Andreas Koops, Susan Koops, Jochen Herrmann, Alexander Hendricks, Iyad Kabar, Alexander Arlt, Felix Braun, Thomas Becker, Christian Wilms
BACKGROUND: The aim of this study was to compare arterial embolization (AE) with portal vein embolization (PVE) for the induction of segmental hypertrophy regarding procedural efficacy, safety and outcome. METHODS: A total of 29 mini pigs were subjected to PVE, AE or assigned to the sham (SO) group. Correspondingly, 75% of the hepatic artery or portal vein branches were embolized. Growth and atrophy of the liver lobes, calculating the liver-to-body weight index (LBWI), laboratory data, arteriography, portography, Doppler ultrasound (US) and histopathology were analyzed...
July 20, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27434273/hemodynamic-assessment-of-a-murine-heterotopic-biventricularly-loaded-cardiac-transplant-in-vivo-model
#15
Agnieszka A Książek, Katharyn J Mitchell, Laurent Morax, Colin C Schwarzwald, Simon P Hoerstrup, Benedikt Weber
BACKGROUND: Heterotopic heart transplantation (HHT) in rodent animal models represents an important technique enabling studies on organ transplantation immunology and pharmaceutical development. Recent investigations used nonworking HHT designs, with the left ventricle (LV) bypassed in the anastomosis system. In spite of their principal success, the lack of orthogonal ventricular filling leads to myocardial atrophy. However, when focusing on the cellular and molecular mechanisms involved in the in vivo remodeling of the myocardium or cell-based cardiovascular implants, a nonworking model is suboptimal as it lacks the native-analogous hemodynamic and metabolic situation...
July 20, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27376374/biographic-characteristics-and-factors-perceived-as-affecting-female-and-male-careers-in-academic-surgery-the-tenured-gender-battle-to-make-it-to-the-top
#16
Laura Schwarz, Sonia Sippel, Andrew Entwistle, Anna Kathrin Hell, Sarah Koenig
PURPOSE: Given the high attrition rate in the field of academic surgery, we aimed to characterise the professional and personal situations of female and male academic surgeons as well as to gather data on their respective perceptions of career advancement and work satisfaction. METHODS: We conducted a cross-sectional survey in Germany, inviting all identifiable academically highly qualified female surgeons and their male counterparts in a 1:2 ratio to participate...
July 5, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27308828/intrahepatic-size-regulation-in-a-surgical-model-liver-resection-induced-liver-regeneration-counteracts-the-local-atrophy-following-simultaneous-portal-vein-ligation
#17
Weiwei Wei, Tianjiao Zhang, Haoshu Fang, Olaf Dirsch, Andrea Schenk, André Homeyer, Felix Gremse, Sara Zafarnia, Utz Settmacher, Uta Dahmen
BACKGROUND/AIM: Liver size regulation is based on the balance between hepatic regeneration and atrophy. To achieve a better understanding of intrahepatic size regulation, we explored the size regulation of a portally deprived liver lobe on a liver subjected to concurrent portal vein ligation (PVL) and partial hepatectomy (PHx). MATERIALS AND METHODS: Using a surgical rat model consisting of right PVL (rPVL) plus 70% PHx, we evaluated the size regulation of liver lobes 1, 2, 3, and 7 days after the operation in terms of liver weight and hepatocyte proliferation...
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27287005/protein-kinase-ck2-regulates-leukocyte-endothelial-cell-interactions-during-ischemia-and-reperfusion-in-striated-skin-muscle
#18
Emmanuel Ampofo, Daniela Widmaier, Mathias Montenarh, Michael D Menger, Matthias W Laschke
BACKGROUND: Ischemia and reperfusion (I/R) causes tissue injury by inflammatory processes. This involves the upregulation of endothelial surface proteins by phospho-regulated signaling pathways, resulting in enhanced interactions of leukocytes with endothelial cells. Recently, we found that protein kinase CK2 is a crucial regulator of leukocyte-mediated inflammation. Therefore, in this study we investigated the involvement of CK2 in leukocyte-endothelial cell interactions during I/R injury...
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27271697/optimal-timing-for-venous-systemic-oxygen-persufflation-supplemented-with-nitric-oxide-gas-in-cold-stored-warm-ischemia-damaged-experimental-liver-grafts
#19
Anne Porschen, Pramod Kadaba Srinivasan, Junji Iwasaki, Mamdouh Afify, René H Tolba
BACKGROUND/AIM: Worldwide shortage of donor organs has increased the use of donation after cardiac death (DCD). The aim of this study was to analyze the best time point for venous systemic oxygen persufflation (VSOP) supplemented with nitric oxide (NO) gas during the 1st and 24th hour of cold storage (CS) in warm ischemia (WI)-damaged experimental liver grafts. MATERIALS AND METHODS: Liver grafts (n = 5) were retrieved after 30 min of WI induced by cardiac arrest and CS in histidine-tryptophan-ketoglutarate solution at 4°C...
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27216411/the-51st-congress-of-the-european-society-for-surgical-research-may-25-28-2016-prague-czech-republic-abstracts
#20
(no author information available yet)
No abstract text is available yet for this article.
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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