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European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes

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https://www.readbyqxmd.com/read/30544106/biology-based-surgery-the-extent-of-lymphadenectomy-in-cancer-of-the-colon
#1
Wouter Willaert, Sarah Cosyns, Wim Ceelen
The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. The Fisher model, on the other hand, regards the release of metastatic cells as early and essentially random events...
December 13, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30537714/glp1-receptor-agonist-liraglutide-is-an-effective-therapeutic-option-for-perioperative-glycemic-control-in-type-2-diabetes-within-enhanced-recovery-after-surgery-eras-protocols
#2
Shizuka Kaneko, Youhei Ueda, Yumiko Tahara
BACKGROUND: Enhanced Recovery After Surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery after surgical procedures by maintaining preoperative organ function and reducing profound stress responses following surgery [Wilmore and Kehlet: BMJ 2001; 322(7284): 473-6]. Glucagon-like peptide-1 receptor agonists (GLP-1RAgs), such as liraglutide, have recently been widely used as antidiabetic agents in patients with type 2 diabetes (T2D) because they maintain blood glucose at an ideal level throughout the day, including during postprandial periods, thereby improving hypoglycemia and body weight more than insulin therapies...
December 11, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30537705/biology-of-nodal-spread-in-colon-cancer-insights-from-molecular-and-genetic-studies
#3
Pridvi Kandagatla, Lilias H Maguire, Karin M Hardiman
Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy...
December 11, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30466084/microsurgical-technique-of-locoregional-injection-into-the-hepatic-artery-in-tumor-bearing-mice
#4
Baifeng Qian, Felix Strübing, Zhe Wang, Arianeb Mehrabi, Eduard Ryschich
BACKGROUND: Intraarterial injection into the hepatic artery represents an important route for locoregional administration for the treatment of hepatic tumors. In the present work, we describe microsurgical methodology for injection into the hepatic artery in mice. The technique was recently used for analysis of the phenomenon of endothelial capture in liver tumors. METHODS: Two different models of hepatic tumors in C57BL/6 mice were used. Tumors were induced by intrahepatic cell inoculation...
November 22, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30453288/predictive-early-recurrence-factors-of-preoperative-clinicophysiological-findings-in-pancreatic-cancer
#5
Shuji Suzuki, Mitsugi Shimoda, Jiro Shimazaki, Tsunehiko Maruyama, Yukio Oshiro, Kiyotaka Nishida, Yatsuka Sahara, Yuichi Nagakawa, Akihiko Tsuchida
BACKGROUND: We aimed to evaluate the use of preoperative clinicophysiological parameters as predictive risk factors for early recurrence of pancreatic ductal adenocarcinoma (PDAC) after curative resection. METHODS: A total of 260 patients who underwent pancreatic resection for PDAC between 2007 and 2015 were examined retrospectively. We divided the patients into those with early recurrence (within 6 months; group A, n = 52) and those with relapse within ≥6 months or without recurrence (group B, n = 208)...
November 19, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30419560/isoform-dependent-changes-in-cytochrome-p450-mediated-drug-metabolism-after-portal-vein-ligation-in-the-rat
#6
Tibor Kovács, Máté Déri, András Fülöp, Tímea Pálházy, Edit Háfra, Dávid Sirok, Ádám Ferenc Kiss, Gábor Lotz, Attila Szijártó, Katalin Monostory
BACKGROUND: Surgical removal of complicated liver tumors may be realized in two stages via selective portal vein ligation, inducing the atrophy of portally ligated lobes and the compensatory hypertrophy of nonligated liver lobes. Unlike morphological changes, functional aspects such as hepatic cytochrome P450 (CYP)-mediated drug metabolism remain vaguely understood, despite its critical role in both drug biotransformation and hepatic functional analysis. Our goal was the multilevel characterization of hepatic CYP-mediated drug metabolism after portal vein ligation in the rat...
November 12, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30419555/a-new-physiologic-mouse-model-of-one-anastomosis-gastric-bypass
#7
Andreas Kroh, Roman M Eickhoff, Daniel Heise, Patrick H Alizai, Karl P Rheinwalt, Ulf P Neumann, Florian T Ulmer
BACKGROUND: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this procedure remain largely unknown and are difficult to address in human studies. Here, we present a new physiologic mouse model for mechanistic and long-term investigations. METHODS: Six-week-old C57Bl/6 mice were fed a high-fat diet for 12 weeks and scheduled for OAGB or sham operation...
November 12, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30458448/the-53rd-congress-of-the-european-society-for-surgical-research
#8
(no author information available yet)
No abstract text is available yet for this article.
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244256/the-crucial-role-of-vascularization-and-lymphangiogenesis-in-skin-reconstruction
#9
REVIEW
Florian S Frueh, Nadia Sanchez-Macedo, Maurizio Calcagni, Pietro Giovanoli, Nicole Lindenblatt
BACKGROUND: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician's perspective. SUMMARY: Graft revascularization is a dynamic combination of inosculation, angiogenesis, and vasculogenesis...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244254/panta-rhei-neovascularization-angiogenesis-and-nutritive-perfusion-in-wound-healing
#10
REVIEW
Heiko Sorg, Daniel J Tilkorn, Ursula Mirastschijski, Joerg Hauser, Robert Kraemer
BACKGROUND: In response to tissue damage, angiogenesis is an extremely dynamic process that is finely regulated by signals from cells, the surrounding extracellular matrix (ECM), and derived mediators. As the only process, angiogenesis remains of decisive importance in the context of the entire wound healing process and is subject to constant change. The dissolution of the endothelial basement membrane, the migration of endothelial cells, and the development of new capillary vessels during wound healing depend not only on the cells and cytokines present, but also on the production and organization of ECM components in the immediate wound...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244251/cell-sheet-based-vascularized-myocardial-tissue-fabrication
#11
REVIEW
Hyoe Komae, Minoru Ono, Tatsuya Shimizu
BACKGROUND: The development of regenerative medicine in recent years has been remarkable as tissue engineering technology and stem cell research have advanced. The ultimate goal of regenerative medicine is to fabricate human organs artificially. If fabricated organs can be transplanted medically, it will be the innovative treatment of diseases for which only donor organ transplantation is the definitive therapeutic method at present. SUMMARY: Our group has reported successful fabrication of thick functional myocardial tissue in vivo and in vitro by using cell sheet engineering technology which requires no scaffolds...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244245/platelet-rich-plasma-in-tissue-engineering-hype-and-hope
#12
REVIEW
Siegmund Lang, Markus Loibl, Marietta Herrmann
BACKGROUND: Platelet-rich plasma (PRP) refers to an enriched platelet suspension in plasma. In addition to the clinical application of PRP in the context of various orthopedic diseases and beyond, PRP and platelet lysate (PL) have been in focus in the field of tissue engineering. In this review, we discuss the application of PRP as a cell culture supplement and as part of tissue engineering strategies, particularly emphasizing current hurdles and ambiguities regarding the efficacy of PRP in these approaches...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244243/vascularization-regeneration-and-tissue-engineering
#13
EDITORIAL
Matthias W Laschke, Brigitte Vollmar
No abstract text is available yet for this article.
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244240/common-rodent-flap-models-in-experimental-surgery
#14
REVIEW
Daniel Schmauss, Andrea Weinzierl, Verena Schmauss, Yves Harder
BACKGROUND: Flap procedures are widely used in clinical reconstructive surgery. Since ische-mia-associated complications, e.g., wound breakdown or tissue necrosis, are still a great challenge in flap surgery, experimental flap models are widely used to study flap physiology and to evaluate treatment strategies to prevent these complications. SUMMARY: Since rodents in general, and mice and rats in particular, are widely used in experimental flap models, we give an overview of the most common flap models in rodents, including the cremaster flap, the osteomyocutaneous flap, the McFarlane flap, the ear flap, and the dorsal skinfold chamber...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244238/the-arteriovenous-loop-engineering-of-axially-vascularized-tissue
#15
REVIEW
Annika Weigand, Raymund E Horch, Anja M Boos, Justus P Beier, Andreas Arkudas
BACKGROUND: Most of the current treatment options for large-scale tissue defects represent a serious burden for the patients, are often not satisfying, and can be associated with significant side effects. Although major achievements have already been made in the field of tissue engineering, the clinical translation in case of extensive tissue defects is only in its early stages. The main challenge and reason for the failure of most tissue engineering approaches is the missing vascularization within large-scale transplants...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30173218/22nd-surgical-research-days
#16
(no author information available yet)
No abstract text is available yet for this article.
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30089287/the-mri-sepsis-score-an-innovative-tool-for-the-evaluation-of-septic-peritonitis-in-mice-using-7-tesla-small-animal-mri
#17
Stephan Diedrich, Julia van der Linde, Michael Nielson, Pia Menges, Jens-Peter Kühn, Andre Käding, Dung Ngyuen Trung, Claus-Dieter Heidecke, Lars Ivo Partecke, Wolfram Kessler
BACKGROUND: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. The most frequently employed readout parameter in mouse CASP studies is prolonged or decreased rate of survival. Monitoring the progression of peritonitis via MRI could provide a helpful tool in the evaluation of severity...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30089286/glycocalyx-degradation-after-pulmonary-transplantation-surgery
#18
Lisa Rancan, Carlos Simón, Guillermo Sánchez Pedrosa, Karen Aymonnier, Priya M Shahani, Javier Casanova, Celia Muñoz, Ignacio Garutti, Elena Vara
PURPOSE: Ischaemia-reperfusion injury (IRI) is a main cause of morbidity after pulmonary resection surgery. The degradation of glycocalyx, a dynamic layer of macromolecules at the luminal surface of the endothelium, seems to participate in tissue dysfunction after IRI. Lidocaine has a proven anti-inflammatory activity in several tissues but its modulation of glycocalyx has not been investigated. This work aimed to investigate the potential involvement of glycocalyx in lung IRI in a lung auto-transplantation model and the possible effect of lidocaine in modulating IRI...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30048992/healthcare-it-utilization-and-penetration-among-physicians-novel-it-solutions-in-healthcare-use-and-acceptance-in-hospitals
#19
Ferdinand Vogt, Fritz Seidl, Giuseppe Santarpino, Martijn van Griensven, Martin Emmert, Guenther Edenharter, Dominik Pförringer
BACKGROUND: Healthcare IT (HIT) increasingly gains public attention and clinical daily relevance. A growing number of patients and physicians increasingly relies on IT services to monitor and support well-being and recovery both in their private and professional environment. This is assumed to develop rapidly in the upcoming years. OBJECTIVE: This study examines the current status of HIT, its use and penetration among physicians in hospitals and researches utilization as well as future expectations regarding HIT...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30032156/glycine-protects-the-liver-from-reperfusion-injury-following-pneumoperitoneum
#20
Mohammed Al-Saeedi, Arash Nickkholgh, Daniel Schultze, Christa Flechtenmacher, Markus Zorn, Rui Liang, Carsten N Gutt, Peter Schemmer
BACKGROUND: Experimental pneumoperitoneum induces ischemia/reperfusion injury (IRI) in the liver, most likely via Kupffer cell (KC)-dependent mechanisms. Glycine has been shown to ameliorate IRI in various animal models. Thus, this study was performed to assess the effects of glycine on the liver after pneumoperitoneum. MATERIALS AND METHODS: Sprague-Dawley rats (220-250 g in weight) underwent CO2 pneumoperitoneum (12 mm Hg) for 90 min. Some rats received i.v. glycine (1...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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