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European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes

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https://www.readbyqxmd.com/read/30089287/the-mri-sepsis-score-an-innovative-tool-for-the-evaluation-of-septic-peritonitis-in-mice-using-7-tesla-small-animal-mri
#1
Stephan Diedrich, Julia van der Linde, Michael Nielson, Pia Menges, Jens-Peter Kühn, Andre Käding, Dung Ngyuen Trung, Claus-Dieter Heidecke, Lars Ivo Partecke, Wolfram Kessler
BACKGROUND: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. The most frequently employed readout parameter in mouse CASP studies is prolonged or decreased rate of survival. Monitoring the progression of peritonitis via MRI could provide a helpful tool in the evaluation of severity...
August 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30089286/glycocalyx-degradation-after-pulmonary-transplantation-surgery
#2
Lisa Rancan, Carlos Simón, Guillermo Sánchez Pedrosa, Karen Aymonnier, Priya M Shahani, Javier Casanova, Celia Muñoz, Ignacio Garutti, Elena Vara
PURPOSE: Ischaemia-reperfusion injury (IRI) is a main cause of morbidity after pulmonary resection surgery. The degradation of glycocalyx, a dynamic layer of macromolecules at the luminal surface of the endothelium, seems to participate in tissue dysfunction after IRI. Lidocaine has a proven anti-inflammatory activity in several tissues but its modulation of glycocalyx has not been investigated. This work aimed to investigate the potential involvement of glycocalyx in lung IRI in a lung auto-transplantation model and the possible effect of lidocaine in modulating IRI...
August 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29886505/influence-of-telomere-length-in-hepatocytes-on-liver-regeneration-after-partial-hepatectomy-in-rats
#3
Anne Andert, Hamid P Alizai, Tom Florian Ulmer, Christoph Heidenhain, Patrick Ziegler, Tim H Brümmendorf, Ulf Peter Neumann, Fabian Beier, Christian D Klink
BACKGROUND: The aim of this study was to investigate telomere length in hepatocytes as a biomarker for liver regeneration after partial hepatectomy (PH) in rats. MATERIALS AND METHODS: Sixty male Wistar rats underwent a 70% PH. One-month-old rats were assigned to group Y (n = 30) and 4-month-old rats were assigned to group O (n = 30). The rats were euthanized, and their livers were then harvested at postoperative day (POD) 1, 2, 3, 4, or 7. Telomere lengths and established parameters for liver regeneration (residual liver weight and levels of proliferating cell nuclear antigen [PCNA], Ki67, and interleukin [IL]-6) were measured...
June 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29719286/serial-assessment-of-growth-factors-associated-with-liver-regeneration-in-patients-operated-with-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#4
Ernesto Sparrelid, Helene Johansson, Stefan Gilg, Greg Nowak, Ewa Ellis, Bengt Isaksson
BACKGROUND: There is limited knowledge about the mechanisms behind the unparalleled growth of the future liver remnant (FLR) linked to associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). In this study, liver regenerative markers were examined in patients subjected to ALPPS. METHODS: Ten patients with colorectal liver metastases treated with neoadjuvant chemotherapy and ALPPS were included. Plasma was sampled at 6 time points and biopsies from both liver lobes were collected at both stages of ALPPS...
May 2, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29621750/enhanced-vascular-biocompatibility-and-remodeling-of-decellularized-and-secured-xenogeneic-allogeneic-matrices-in-a-porcine-model
#5
Mathieu van Steenberghe, Thomas Schubert, Caroline Bouzin, Carlo Caravaggio, Yves Guiot, Daela Xhema, Pierre Gianello
BACKGROUND/PURPOSE: Calcifications and absence of growth potential are the major drawbacks of glutaraldehyde-treated prosthesis. Decellularized and secured xeno-/allogeneic matrices were assessed in a preclinical porcine model for biocompatibility and vascular remodeling in comparison to glutaraldehyde-fixed bovine pericardium (GBP; control). METHODS: Native human (fascia lata, pericardium) and porcine tissues (peritoneum) were used and treated. In vitro, biopsies were performed before and after treatment to assess decellularization (hematoxylin and eosin/DAPI)...
April 5, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29462813/hemostatic-efficacy-and-safety-of-the-novel-medical-adhesive-mar-vivo-107-in-a-rabbit-liver-resection-model
#6
Kenji Fukushima, Hirokazu Tanaka, Pramod Kadaba Srinivasan, Kerstin Pawlowsky, Babette Kögel, Shinji Uemoto, Yonson Ku, René H Tolba
BACKGROUND: Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. METHODS: Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (n = 10), fibrin glue (n = 10), and saline groups (n = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area...
February 20, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29393259/influence-of-parathyroidectomy-on-bone-metabolism-and-bone-pain-in-patients-with-secondary-hyperparathyroidism
#7
Ralph Schneider, Carolin Steinmetz, Elias Karakas, Detlef K Bartsch, Katja Schlosser
BACKGROUND: After parathyroidectomy (PTX), hungry bone syndrome leads to hypocalcemia due to bone remineralization. The aim of this pilot study was to analyze changes in markers of bone metabolism in patients with secondary hyperparathyroidism (sHPT) after PTX and to correlate these markers with bone pain measured with a validated questionnaire. MATERIALS AND METHODS: All patients who underwent PTX for sHPT between March 2010 and February 2012 at out institution were included in this prospective observational pilot study...
January 23, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29393202/quantification-of-adipose-tissue-and-muscle-mass-based-on-computed-tomography-scans-comparison-of-eight-planimetric-and-diametric-techniques-including-a-step-by-step-guide
#8
Thomas Irlbeck, Silke Janitza, Balázs Poros, Monika Golebiewski, Lorenz Frey, Philipp M Paprottka, Teresa da Silva, Michael Irlbeck, Wolfgang Böcker, Thomas Weig
BACKGROUND: Recent scientific work proved that knowledge about body composition beyond the body mass index is essential. Both adipose tissue and muscular status are determining risk factors of morbidity and mortality. Analysis of single cross-sectional computed tomography (CT) images, acquired during routine care only to prevent additional radiation exposure, provide a detailed insight into the body composition of chronically and critically ill patients. METHODS: This retrospective study included 490 trauma patients of whom a whole-body multiple detector CT scan was acquired at admission...
January 23, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29332090/impaired-value-of-99m-tc-gsa-scintigraphy-as-an-independent-risk-factor-for-posthepatectomy-liver-failure-in-patients-with-hepatocellular-carcinoma
#9
Ikuo Nakamura, Yuji Iimuro, Seikan Hai, Yuichi Kondo, Etsuro Hatano, Jiro Fujimoto
BACKGROUND: Posthepatectomy liver failure (PHLF) was recently defined with the corresponding recommendations as follows: grade A, no change in clinical management; grade B, clinical management with noninvasive treatment; and grade C, clinical management with invasive treatment. In this study, we identified the risk factors for grade B and C PHLF in patients with hepatocellular carcinoma (HCC). METHODS: Of 339 HCC patients who underwent curative hepatic resection, 218 were included for analysis...
January 12, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29320769/electronic-nose-in-the-detection-of-wound-infection-bacteria-from-bacterial-cultures-a-proof-of-principle-study
#10
Taavi Saviauk, Juha P Kiiski, Maarit K Nieminen, Nelly N Tamminen, Antti N Roine, Pekka S Kumpulainen, Lauri J Hokkinen, Markus T Karjalainen, Risto E Vuento, Janne J Aittoniemi, Terho J Lehtimäki, Niku K Oksala
BACKGROUND: Soft tissue infections, including postoperative wound infections, result in a significant burden for modern society. Rapid diagnosis of wound infections is based on bacterial stains, cultures, and polymerase chain reaction assays, and the results are available earliest after several hours, but more often not until days after. Therefore, antibiotic treatment is often administered empirically without a specific diagnosis. METHODS: We employed our electronic nose (eNose) system for this proof-of-concept study, aiming to differentiate the most relevant bacteria causing wound infections utilizing a set of clinical bacterial cultures on identical blood culture dishes, and established bacterial lines from the gaseous headspace...
January 10, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30048992/healthcare-it-utilization-and-penetration-among-physicians-novel-it-solutions-in-healthcare-use-and-acceptance-in-hospitals
#11
Ferdinand Vogt, Fritz Seidl, Giuseppe Santarpino, Martijn van Griensven, Martin Emmert, Guenther Edenharter, Dominik Pförringer
BACKGROUND: Healthcare IT (HIT) increasingly gains public attention and clinical daily relevance. A growing number of patients and physicians increasingly relies on IT services to monitor and support well-being and recovery both in their private and professional environment. This is assumed to develop rapidly in the upcoming years. OBJECTIVE: This study examines the current status of HIT, its use and penetration among physicians in hospitals and researches utilization as well as future expectations regarding HIT...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30032156/glycine-protects-the-liver-from-reperfusion-injury-following-pneumoperitoneum
#12
Mohammed Al-Saeedi, Arash Nickkholgh, Daniel Schultze, Christa Flechtenmacher, Markus Zorn, Rui Liang, Carsten N Gutt, Peter Schemmer
BACKGROUND: Experimental pneumoperitoneum induces ischemia/reperfusion injury (IRI) in the liver, most likely via Kupffer cell (KC)-dependent mechanisms. Glycine has been shown to ameliorate IRI in various animal models. Thus, this study was performed to assess the effects of glycine on the liver after pneumoperitoneum. MATERIALS AND METHODS: Sprague-Dawley rats (220-250 g in weight) underwent CO2 pneumoperitoneum (12 mm Hg) for 90 min. Some rats received i.v. glycine (1...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29649821/135th-congress-of-the-german-society-of-surgery-dgch
#13
(no author information available yet)
No abstract text is available yet for this article.
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28903097/21st-surgical-research-days-section-of-surgical-research-of-the-german-society-of-surgery-september-21-23-2017-cologne-germany-abstracts
#14
(no author information available yet)
No abstract text is available yet for this article.
September 14, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29073604/cardiac-mesenchymal-stem-cells-proliferate-early-in-the-ischemic-heart
#15
Christian Klopsch, Anna Skorska, Marion Ludwig, Ralf Gaebel, Heiko Lemcke, Gabriela Kleiner, Martin Beyer, Brigitte Vollmar, Robert David, Gustav Steinhoff
BACKGROUND/PURPOSE: Cardiac mesenchymal stem cells (MSCs) could stimulate cell-specific regenerative mechanisms after myocardial infarction (MI) depending on spatial origin, distribution, and niche regulation. We aimed at identifying and isolating tissue-specific cardiac MSCs that could contribute to regeneration. METHODS: Following permanent ligation of the left anterior descending coronary artery in rats (n = 16), early cardiac tissues and cardiac mononuclear cells (MNCs) were analyzed by immunohistology, confocal laser scanning microscopy, and flow cytometry, respectively...
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29073603/vascular-endothelial-dysfunction-during-cardiac-surgery-on-pump-versus-off-pump-coronary-surgery
#16
Florian Brettner, Daniel Chappell, Lisa Schwartz, Alexander Lukasz, Philipp Kümpers, Bernhard F Becker, Bruno Reichart, Markus Rehm, Dirk Bruegger
BACKGROUND: Cardiac surgery often causes ischemia and development of a systemic inflammatory response syndrome, which impairs vascular barrier function, normally maintained by the endothelial cell line and the endothelial glycocalyx (EG). The EG normally covers and protects healthy endothelial cells throughout the vasculature. The aim of the present study was to assess the disruption of the cellular part of the microvascular barrier by determining parameters of endothelial cell activation known to influence and reflect cell-cell junctional integrity...
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29073598/expression-of-vegfr-2-during-liver-regeneration-after-partial-hepatectomy-in-a-bioluminescence-mouse-model
#17
Patrick Hamid Alizai, Lea Bertram, Daniela Kroy, Julia Kummer, Anne Andert, Ulf Peter Neumann, Tom Florian Ulmer, Athanassious Fragoulis
BACKGROUND: Liver regeneration requires the formation of new blood vessels. Endothelial cell proliferation is stimulated by vascular endothelial growth factor (VEGF) and its receptor tyrosine kinase VEGFR-2. The aim of this study was to investigate VEGFR-2 expression in vivo during liver regeneration after partial hepatectomy (PHx). METHODS: Transgenic VEGFR-2-luc mice were used in which the luciferase reporter gene was under control of the VEGFR-2 promoter. Following 2/3 PHx, the mice underwent in vivo bioluminescence imaging until the 14th postoperative day...
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28930745/the-52nd-congress-of-the-european-society-for-surgical-research-june-14-17-2017-amsterdam-the-netherlands-abstracts
#18
(no author information available yet)
No abstract text is available yet for this article.
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28793287/early-discharge-programme-on-hospital-at-home-evaluation-for-patients-with-immediate-postoperative-course-after-laparoscopic-colorectal-surgery
#19
Marcos Pajarón-Guerrero, Manuel Francisco Fernández-Miera, Juan Carlos Dueñas-Puebla, Carmen Cagigas-Fernández, Iciar Allende-Mancisidor, Lidia Cristóbal-Poch, Manuel Gómez-Fleitas, Maria Asuncion Manzano-Peral, Carmen Rosa Gonzalez-Fernandez, Ana Aguilera-Zubizarreta, Pedro Sanroma-Mendizábal
BACKGROUND: To audit the safety of the early hospital discharge care model offered by a Hospital-at-home (HAH) unit during early postoperative follow-up of these patients, and to determine whether this care model is more efficient compared to the traditional care model. METHODS: A prospective study of 50 patients included consecutively for 1 year in an early discharge programme after laparoscopic colorectal surgery was performed. As of day 3 after surgery, if the patient met the relevant inclusion criteria they were transferred to the HAH unit...
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28746936/defining-standards-in-experimental-microsurgical-training-recommendations-of-the-european-society-for-surgical-research-essr-and-the-international-society-for-experimental-microsurgery-isem
#20
René H Tolba, Zoltán Czigány, Suzanne Osorio Lujan, Mihai Oltean, Michael Axelsson, Yelena Akelina, Antonio Di Cataldo, Iren Miko, Istvan Furka, Uta Dahmen, Eiji Kobayashi, Mihai Ionac, Norbert Nemeth
BACKGROUND: Expectations towards surgeons in modern surgical practice are extremely high with minimal complication rates and maximal patient safety as paramount objectives. Both of these aims are highly dependent on individual technical skills that require sustained, focused, and efficient training outside the clinical environment. At the same time, there is an increasing moral and ethical pressure to reduce the use of animals in research and training, which has fundamentally changed the practice of microsurgical training and research...
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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