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European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes

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https://www.readbyqxmd.com/read/30244256/the-crucial-role-of-vascularization-and-lymphangiogenesis-in-skin-reconstruction
#1
REVIEW
Florian S Frueh, Nadia Sanchez-Macedo, Maurizio Calcagni, Pietro Giovanoli, Nicole Lindenblatt
BACKGROUND: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician's perspective. SUMMARY: Graft revascularization is a dynamic combination of inosculation, angiogenesis, and vasculogenesis...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244254/panta-rhei-neovascularization-angiogenesis-and-nutritive-perfusion-in-wound-healing
#2
REVIEW
Heiko Sorg, Daniel J Tilkorn, Ursula Mirastschijski, Joerg Hauser, Robert Kraemer
BACKGROUND: In response to tissue damage, angiogenesis is an extremely dynamic process that is finely regulated by signals from cells, the surrounding extracellular matrix (ECM), and derived mediators. As the only process, angiogenesis remains of decisive importance in the context of the entire wound healing process and is subject to constant change. The dissolution of the endothelial basement membrane, the migration of endothelial cells, and the development of new capillary vessels during wound healing depend not only on the cells and cytokines present, but also on the production and organization of ECM components in the immediate wound...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244251/cell-sheet-based-vascularized-myocardial-tissue-fabrication
#3
REVIEW
Hyoe Komae, Minoru Ono, Tatsuya Shimizu
BACKGROUND: The development of regenerative medicine in recent years has been remarkable as tissue engineering technology and stem cell research have advanced. The ultimate goal of regenerative medicine is to fabricate human organs artificially. If fabricated organs can be transplanted medically, it will be the innovative treatment of diseases for which only donor organ transplantation is the definitive therapeutic method at present. SUMMARY: Our group has reported successful fabrication of thick functional myocardial tissue in vivo and in vitro by using cell sheet engineering technology which requires no scaffolds...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244245/platelet-rich-plasma-in-tissue-engineering-hype-and-hope
#4
REVIEW
Siegmund Lang, Markus Loibl, Marietta Herrmann
BACKGROUND: Platelet-rich plasma (PRP) refers to an enriched platelet suspension in plasma. In addition to the clinical application of PRP in the context of various orthopedic diseases and beyond, PRP and platelet lysate (PL) have been in focus in the field of tissue engineering. In this review, we discuss the application of PRP as a cell culture supplement and as part of tissue engineering strategies, particularly emphasizing current hurdles and ambiguities regarding the efficacy of PRP in these approaches...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244243/vascularization-regeneration-and-tissue-engineering
#5
EDITORIAL
Matthias W Laschke, Brigitte Vollmar
No abstract text is available yet for this article.
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244240/common-rodent-flap-models-in-experimental-surgery
#6
REVIEW
Daniel Schmauss, Andrea Weinzierl, Verena Schmauss, Yves Harder
BACKGROUND: Flap procedures are widely used in clinical reconstructive surgery. Since ische-mia-associated complications, e.g., wound breakdown or tissue necrosis, are still a great challenge in flap surgery, experimental flap models are widely used to study flap physiology and to evaluate treatment strategies to prevent these complications. SUMMARY: Since rodents in general, and mice and rats in particular, are widely used in experimental flap models, we give an overview of the most common flap models in rodents, including the cremaster flap, the osteomyocutaneous flap, the McFarlane flap, the ear flap, and the dorsal skinfold chamber...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30244238/the-arteriovenous-loop-engineering-of-axially-vascularized-tissue
#7
REVIEW
Annika Weigand, Raymund E Horch, Anja M Boos, Justus P Beier, Andreas Arkudas
BACKGROUND: Most of the current treatment options for large-scale tissue defects represent a serious burden for the patients, are often not satisfying, and can be associated with significant side effects. Although major achievements have already been made in the field of tissue engineering, the clinical translation in case of extensive tissue defects is only in its early stages. The main challenge and reason for the failure of most tissue engineering approaches is the missing vascularization within large-scale transplants...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30173218/22nd-surgical-research-days
#8
(no author information available yet)
No abstract text is available yet for this article.
August 31, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30089287/the-mri-sepsis-score-an-innovative-tool-for-the-evaluation-of-septic-peritonitis-in-mice-using-7-tesla-small-animal-mri
#9
Stephan Diedrich, Julia van der Linde, Michael Nielson, Pia Menges, Jens-Peter Kühn, Andre Käding, Dung Ngyuen Trung, Claus-Dieter Heidecke, Lars Ivo Partecke, Wolfram Kessler
BACKGROUND: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. The most frequently employed readout parameter in mouse CASP studies is prolonged or decreased rate of survival. Monitoring the progression of peritonitis via MRI could provide a helpful tool in the evaluation of severity...
August 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30089286/glycocalyx-degradation-after-pulmonary-transplantation-surgery
#10
Lisa Rancan, Carlos Simón, Guillermo Sánchez Pedrosa, Karen Aymonnier, Priya M Shahani, Javier Casanova, Celia Muñoz, Ignacio Garutti, Elena Vara
PURPOSE: Ischaemia-reperfusion injury (IRI) is a main cause of morbidity after pulmonary resection surgery. The degradation of glycocalyx, a dynamic layer of macromolecules at the luminal surface of the endothelium, seems to participate in tissue dysfunction after IRI. Lidocaine has a proven anti-inflammatory activity in several tissues but its modulation of glycocalyx has not been investigated. This work aimed to investigate the potential involvement of glycocalyx in lung IRI in a lung auto-transplantation model and the possible effect of lidocaine in modulating IRI...
August 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30048992/healthcare-it-utilization-and-penetration-among-physicians-novel-it-solutions-in-healthcare-use-and-acceptance-in-hospitals
#11
Ferdinand Vogt, Fritz Seidl, Giuseppe Santarpino, Martijn van Griensven, Martin Emmert, Guenther Edenharter, Dominik Pförringer
BACKGROUND: Healthcare IT (HIT) increasingly gains public attention and clinical daily relevance. A growing number of patients and physicians increasingly relies on IT services to monitor and support well-being and recovery both in their private and professional environment. This is assumed to develop rapidly in the upcoming years. OBJECTIVE: This study examines the current status of HIT, its use and penetration among physicians in hospitals and researches utilization as well as future expectations regarding HIT...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30032156/glycine-protects-the-liver-from-reperfusion-injury-following-pneumoperitoneum
#12
Mohammed Al-Saeedi, Arash Nickkholgh, Daniel Schultze, Christa Flechtenmacher, Markus Zorn, Rui Liang, Carsten N Gutt, Peter Schemmer
BACKGROUND: Experimental pneumoperitoneum induces ischemia/reperfusion injury (IRI) in the liver, most likely via Kupffer cell (KC)-dependent mechanisms. Glycine has been shown to ameliorate IRI in various animal models. Thus, this study was performed to assess the effects of glycine on the liver after pneumoperitoneum. MATERIALS AND METHODS: Sprague-Dawley rats (220-250 g in weight) underwent CO2 pneumoperitoneum (12 mm Hg) for 90 min. Some rats received i.v. glycine (1...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29886505/influence-of-telomere-length-in-hepatocytes-on-liver-regeneration-after-partial-hepatectomy-in-rats
#13
Anne Andert, Hamid P Alizai, Tom Florian Ulmer, Christoph Heidenhain, Patrick Ziegler, Tim H Brümmendorf, Ulf Peter Neumann, Fabian Beier, Christian D Klink
BACKGROUND: The aim of this study was to investigate telomere length in hepatocytes as a biomarker for liver regeneration after partial hepatectomy (PH) in rats. MATERIALS AND METHODS: Sixty male Wistar rats underwent a 70% PH. One-month-old rats were assigned to group Y (n = 30) and 4-month-old rats were assigned to group O (n = 30). The rats were euthanized, and their livers were then harvested at postoperative day (POD) 1, 2, 3, 4, or 7. Telomere lengths and established parameters for liver regeneration (residual liver weight and levels of proliferating cell nuclear antigen [PCNA], Ki67, and interleukin [IL]-6) were measured...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29719286/serial-assessment-of-growth-factors-associated-with-liver-regeneration-in-patients-operated-with-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#14
Ernesto Sparrelid, Helene Johansson, Stefan Gilg, Greg Nowak, Ewa Ellis, Bengt Isaksson
BACKGROUND: There is limited knowledge about the mechanisms behind the unparalleled growth of the future liver remnant (FLR) linked to associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). In this study, liver regenerative markers were examined in patients subjected to ALPPS. METHODS: Ten patients with colorectal liver metastases treated with neoadjuvant chemotherapy and ALPPS were included. Plasma was sampled at 6 time points and biopsies from both liver lobes were collected at both stages of ALPPS...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29649821/135th-congress-of-the-german-society-of-surgery-dgch
#15
(no author information available yet)
No abstract text is available yet for this article.
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29621750/enhanced-vascular-biocompatibility-and-remodeling-of-decellularized-and-secured-xenogeneic-allogeneic-matrices-in-a-porcine-model
#16
Mathieu van Steenberghe, Thomas Schubert, Caroline Bouzin, Carlo Caravaggio, Yves Guiot, Daela Xhema, Pierre Gianello
BACKGROUND/PURPOSE: Calcifications and absence of growth potential are the major drawbacks of glutaraldehyde-treated prosthesis. Decellularized and secured xeno-/allogeneic matrices were assessed in a preclinical porcine model for biocompatibility and vascular remodeling in comparison to glutaraldehyde-fixed bovine pericardium (GBP; control). METHODS: Native human (fascia lata, pericardium) and porcine tissues (peritoneum) were used and treated. In vitro, biopsies were performed before and after treatment to assess decellularization (hematoxylin and eosin/DAPI)...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29462813/hemostatic-efficacy-and-safety-of-the-novel-medical-adhesive-mar-vivo-107-in-a-rabbit-liver-resection-model
#17
Kenji Fukushima, Hirokazu Tanaka, Pramod Kadaba Srinivasan, Kerstin Pawlowsky, Babette Kögel, Shinji Uemoto, Yonson Ku, René H Tolba
BACKGROUND: Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. METHODS: Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (n = 10), fibrin glue (n = 10), and saline groups (n = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29393259/influence-of-parathyroidectomy-on-bone-metabolism-and-bone-pain-in-patients-with-secondary-hyperparathyroidism
#18
Ralph Schneider, Carolin Steinmetz, Elias Karakas, Detlef K Bartsch, Katja Schlosser
BACKGROUND: After parathyroidectomy (PTX), hungry bone syndrome leads to hypocalcemia due to bone remineralization. The aim of this pilot study was to analyze changes in markers of bone metabolism in patients with secondary hyperparathyroidism (sHPT) after PTX and to correlate these markers with bone pain measured with a validated questionnaire. MATERIALS AND METHODS: All patients who underwent PTX for sHPT between March 2010 and February 2012 at out institution were included in this prospective observational pilot study...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29393202/quantification-of-adipose-tissue-and-muscle-mass-based-on-computed-tomography-scans-comparison-of-eight-planimetric-and-diametric-techniques-including-a-step-by-step-guide
#19
Thomas Irlbeck, Silke Janitza, Balázs Poros, Monika Golebiewski, Lorenz Frey, Philipp M Paprottka, Teresa da Silva, Michael Irlbeck, Wolfgang Böcker, Thomas Weig
BACKGROUND: Recent scientific work proved that knowledge about body composition beyond the body mass index is essential. Both adipose tissue and muscular status are determining risk factors of morbidity and mortality. Analysis of single cross-sectional computed tomography (CT) images, acquired during routine care only to prevent additional radiation exposure, provide a detailed insight into the body composition of chronically and critically ill patients. METHODS: This retrospective study included 490 trauma patients of whom a whole-body multiple detector CT scan was acquired at admission...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29332090/impaired-value-of-99m-tc-gsa-scintigraphy-as-an-independent-risk-factor-for-posthepatectomy-liver-failure-in-patients-with-hepatocellular-carcinoma
#20
Ikuo Nakamura, Yuji Iimuro, Seikan Hai, Yuichi Kondo, Etsuro Hatano, Jiro Fujimoto
BACKGROUND: Posthepatectomy liver failure (PHLF) was recently defined with the corresponding recommendations as follows: grade A, no change in clinical management; grade B, clinical management with noninvasive treatment; and grade C, clinical management with invasive treatment. In this study, we identified the risk factors for grade B and C PHLF in patients with hepatocellular carcinoma (HCC). METHODS: Of 339 HCC patients who underwent curative hepatic resection, 218 were included for analysis...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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