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Journal of Reproductive Medicine

Steffen A Brown, Rebecca Hall, Lauren Hund, Hilda L Gutierrez, Timothy Hurley, Bradley D Holbrook, Ludmila N Bakhireva
OBJECTIVE: While prenatal 3D ultrasonography results in improved diagnostic accuracy, no data are available on biometric assessment of the fetal frontal lobe. This study was designed to assess feasibility of a standardized approach to biometric measurement of the fetal frontal lobe and to construct frontal lobe growth trajectories throughout gestation. STUDY DESIGN: A sonographic 3D volume set was obtained and measured in 101 patients between 16.1 and 33.7 gestational weeks...
March 2017: Journal of Reproductive Medicine
Laura Garrison, Lawrence Leeman, Renate D Savich, Hilda Gutierrez, William F Rayburn, Ludmila N Bakhireva
OBJECTIVES: To evaluate the effects of prenatal polydrug and exclusive opioid use on fetal growth outcomes. METHODS: This analysis relied on the data obtained from two prospective cohorts at the University of New Mexico. For both cohorts, pregnant women were recruited during one of their prenatal care visits and followed up to delivery. The merged sample included 59 polydrug users, 22 exclusive opioid users, and 278 abstinent controls. Continuous growth measures (birth weight, height, occipital frontal circumference [OFC], and corresponding sex-specific percentiles) were compared by ANOVA and ANCOVA in bivariate and multivariable analyses, respectively...
July 2016: Journal of Reproductive Medicine
Elias D Abi Khalil, Sami M Mufarrij, Gaby N Moawad, Imad S Mufarrij
BACKGROUND: Bilateral tubal pregnancies in the absence of preceding induction of ovulation are rare. They are usually diagnosed at the time of surgery. CASE: We report a case of spontaneous bilateral tubal pregnancies diagnosed intraoperatively. A 28-year-old primigravida presented with light vaginal bleeding and abdominal pain 6 weeks after her last menstrual period. Her β-hCG level was 8,240 mIU/mL. Ultrasonography showed evidence of right tubal ectopic pregnancy...
May 2016: Journal of Reproductive Medicine
Salma A Mahmoud, Lizhi Zhang, Chenyu Jia, Hong Zang
BACKGROUND: Little prospective data exist on associations between polycystic ovary syndrome (PCOS) and long-term metabolic disorders/endometrial malignancy in women. We report the cases of 2 obese, infertile women with PCOS who experienced long-term adverse metabolic and endometrial consequences. CASE: The first woman developed type 2 diabetes and hypertension after a 10-year history of PCOS and subsequent endometrioid carcinoma after having PCOS for 16 years. The second woman was first diagnosed with endometrial atypical hyperplasia, which failed to respond to high-dose progestin treatment, and then was diagnosed with PCOS after a 10-year history of oligomenorrhea...
May 2016: Journal of Reproductive Medicine
Irene Dimitriadis, Kelly Pagidas, Denis Vaughan, Young B Kim
BACKGROUND: Cases of women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome developing leiomyomata are rare. A case with mitotically active leiomyomata has not previously been described to our knowledge. CASE: A 43-year-old woman with MRKH syndrome found to have an incidental pelvic mass on imaging studies underwent a diagnostic laparoscopy, followed by resection of leiomyomata and uterine remnant via mini laparotomy. Histopathology revealed focal infarction associated with a mitotically active area in one of the leiomyomata but with no evidence of marked cytologic atypia or hypercellularity...
May 2016: Journal of Reproductive Medicine
Vaya W Tanamai, Brandon-Luke L Seagle, Guoyang Luo
BACKGROUND: The incidence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing, and 0.5-4% of pregnant women are colonized. CASE: A 30-year-old pregnant woman at term presented with intractable headache 1 week after incision and drainage of a MRSA-positive axillary abscess. Imaging demonstrated a right-sided epidural abscess with midline shift and myositis of the overlying temporalis muscle. She underwent cesarean delivery followed by craniectomy of osteomyelitic bone and evacuation of the epidural abscess...
May 2016: Journal of Reproductive Medicine
Ayako Muraoka, Hiroyuki Tsuda, Tomomi Kotani, Fumitaka Kikkawa
BACKGROUND: Müllerian tract anomalies have been reported in 2-3% of females. Uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis (OHVIRA) syndrome is a rare condition, with only a few cases of the syndrome occurring during pregnancy having been reported. CASE: A 35-year-old, nulli-gravid woman at 18 weeks of gestation was referred due to cervical incompetence. Her first symptom was genital bleeding. Ultrasonography and MRI led to the diagnosis of OHVIRA syndrome, and pregnancy was confirmed on the affected side with the amniotic sac found to be protruding from the cervix into the vaginal cavity...
May 2016: Journal of Reproductive Medicine
Julia Geynisman-Tan, William J Ledger
BACKGROUND: Vulvodynia is a difficult-to-treat, chronic, multifactorial malady that drastically lowers the quality of life of afflicted patients. CASE: A 68-year-old woman, who had been treated successfully for vulvodynia years before with medication, returned with a recurrence of vulvodynia symptoms that this time did not respond to treatment. She now had biopsy-confirmed lichen sclerosis and was found to have markedly elevated serum testosterone levels. An imaging study detected an ovarian lesion that, on removal, proved to be afibrothecoma...
May 2016: Journal of Reproductive Medicine
Guoyan Liu, Xiaobin Shang, Bibo Yuan, Cha Han, Yingmei Wang
OBJECTIVE: To describe our experience with the diagnosis and management of acute fatty liver of pregnancy (AFLP). STUDY DESIGN: The medical records of pregnant women with AFLP were reviewed for symptoms, laboratory findings, treatment, and maternal and fetal outcomes during a 10-year period between January 2003 and December 2013. RESULTS: During the study period 15 women had AFLP as their discharge diagnosis. The mean gestational age at onset was 36 ± 1 weeks...
May 2016: Journal of Reproductive Medicine
Bang Hyun Lee, Jae Hoon Kim, Tae Chul Park, Hee Joong Lee
OBJECTIVE: To investigate the relationship between gonadotropin-releasing hormone (GnRH)/gonadotropin-releasing hormone receptor (GnRHR) signaling and progesterone receptors (PGRs). STUDY DESIGN: HTR-8/SV neo cells and JEG-3 cells were incubated for 24 hours with GnRH-I or -II. The expression of PGRs was measured by quantitative real-time reverse transcriptase-polymerase chain reaction and Western blotting. RESULTS: In both cells lines after incubation with 1-1,000 nM/L GnRH-I or -II the ratio of PGR-B to PGR-AB mRNA level did not differ in any of the groups as compared to the control...
May 2016: Journal of Reproductive Medicine
Hong Cui, Yi Chen, QiuLing Li, Jing Chen, CaiXia Liu, Weiyuan Zhang
OBJECTIVE: To determine the risk factors for breech birth, as well as the rates of cesarean section in singleton breech births in different Chinese provinces. STUDY DESIGN: This retrospective, cross-sectional study included 109,736 singleton preterm and term infants, with 4,535 presenting breech. The risk factors of singleton breech were calculated by using multiple logistic regression analysis based on a cohort design (4,535 breech, 103,484 cephalic presentation)...
May 2016: Journal of Reproductive Medicine
Michael J Butcher, Jabin Janoo, Mike Broce, Dara J Seybold, Pickens Gantt, Gary Randall
OBJECTIVE: To test the hypothesis that morphology is the best predictor of clinical pregnancy (CP) when employing intrauterine insemination (IUI). STUDY DESIGN: We retrospectively reviewed a registry of 527 couples who collectively underwent 1,027 IUI cycles, testing sperm parameters and other variables with univariate and multivariate analyses for association with CP. With the literature scant regarding the impact of sperm morphology on IUI outcome, we determined semen parameter threshold values in our patient population and compared them to published reference range values...
May 2016: Journal of Reproductive Medicine
Shanshan Wang, Lijun Ding, Xia Zhao, Ningyuan Zhang, Yali Hu, Haixiang Sun
OBJECTIVE: To evaluate whether the selection of embryos based on the combination of cleavage patterns and timing parameters using time-lapse imaging could improve the pregnancy outcomes of single embryo transfer (SET) on day 3. STUDY DESIGN: A total of 1,728 normally fertilized and cleaved embryos were included to establish the selection criteria by using time-lapse imaging (TLI). The association of embryo cleavage patterns, timing parameters, and blastocyst quality was evaluated...
May 2016: Journal of Reproductive Medicine
Alaattin Ozturk, Cengiz Kaya, Hakan Bozkurtoglu, Necati Tan, Zuhal Demirhan Yananli, Ergun Ucmakli
OBJECTIVE: To illustrate and emphasize the need for keeping scar endometrioma in mind in order to facilitate an early diagnosis in cases of a mass detected on the abdominal wall in women who have undergone a cesarean section. STUDY DESIGN: Records of 21 patients were reviewed retrospectively. All the patients complained of a mass on the abdominal wall and had undergone cesarean section in the past. Endometrioma was confirmed histopathologically for each patient...
May 2016: Journal of Reproductive Medicine
Maria C B de Leon, Howard H Wu, Ashley E Lennon, Giuseppe Del Priore
OBJECTIVE: To evaluate a new device for obtaining endometrial biopsies which combines global endometrial disruption using a brush with a built-in suction process. STUDY DESIGN: Endometrial biopsies were collected, using the GDP-Tao device, from fresh uteri hysterectomy specimens after completion of surgery. Results were compared to final hysterectomy pathology. Specificity and sensitivity and positive and negative predictive values were calculated. RESULTS: Based on a sample size calculation, 42 patients were included in this study...
May 2016: Journal of Reproductive Medicine
Ruangsak Lertkhachonsuk, Varangkana Wairachpanich
OBJECTIVE: To evaluate changes in treatment outcomes and epidemiologic profiles of gestational trophoblastic neoplasia (GTN) patients over a 20-year period. STUDY DESIGN: This retrospective study recruited all GTN patients who were treated at King Chulalongkorn Memorial Hospital during the period January 1994-December 2013. Clinical data were collected. Statistical analyses were performed, with p values < 0.05 considered statistically significant. RESULTS: There were 183 GTN cases during the study period, resulting in an incidence of 1...
May 2016: Journal of Reproductive Medicine
Sarah Gillett, Kam Singh, Jane Ireson, Annie Hills, Matthew Winter, John Tidy, Ruth Logan, Barry Hancock
OBJECTIVE: To describe the evolution of a teenage and young adult (TYA) service for patients with gestational trophoblastic neoplasia (GTN). BACKGROUND: Since its opening in 2002 the TYA unit has demonstrated its effectiveness and ability to care for GTN patients, offering additional emotional assessment and meeting the specific needs that many young GTN patients have. Patients using the TYA unit were identified from the Centre's databases, and individual records were scrutinized for demographics, clinical presentation, barriers to care, compliance, and specific needs...
May 2016: Journal of Reproductive Medicine
Arb-Aroon Lertkhachonsuk, Piya Hanvoravongchai
OBJECTIVE: To compare the cost-effectiveness between actinomycin D (Act-D) and methotrexate-folinic acid (MTX-FA) in the treatment of low-risk gestational trophoblastic neoplasia (GTN) in the Thai population. STUDY DESIGN: A comparative cost-effectiveness analysis was performed from a societal perspective. A decision tree model was developed comparing 2 alternative treatment options: initial 5-day Act-D and 8-day MTX-FA. Treatment would be switched to another regimen in case of resistance...
May 2016: Journal of Reproductive Medicine
Antonio Braga, Marcelo Burlá, Fernanda Freitas, Elza Uberti, Mauricio Viggiano, Sue Yazaki Sun, Izildinha Maestá, Kevin M Elias, Ross S Berkowitz
OBJECTIVE: To report on the Brazilian Association of Gestational Trophoblastic Disease's (GTD) formation of a network of regional care at specialized centers for women with GTD. STUDY DESIGN: We developed a questionnaire composed of 15 questions, which was sent by email to the 38 Brazilian GTD Reference Center (BGTDRC) Directors who are members of the Brazilian Association of GTD, in order to characterize the professionals involved in the care of patients with GTD and the type of assistance provided...
May 2016: Journal of Reproductive Medicine
Hirokazu Usui, Takako Kiyokawa, Jia Qu, Kyoko Nishikimi, Shinichi Tate, Akira Mitsuhashi, Yukio Nakatani, Makio Shozu
OBJECTIVE: To elucidate the diagnostic accuracy of macroscopic and histopathological diagnoses of molar pregnancy as compared with cytogenetic diagnosis as the gold standard. STUDY DESIGN: Patients were recruited for the molecular diagnostic study of suspected molar pregnancy at Chiba University Hospital between 2007 and 2011. Gynecologists performed macroscopic diagnoses immediately after the evacuation. Pathological diagnoses were then made by pathologists in routine bases without performing p57Kip2 immunostaining...
May 2016: Journal of Reproductive Medicine
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