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Journal of Chromatographic Science

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https://www.readbyqxmd.com/read/28430895/corrigendum
#1
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April 19, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28407087/rp-hplc-separation-of-isomeric-withanolides-method-development-validation-and-application-to-in-situ-rat-permeability-determination
#2
Mohd Yaseen Malik, Isha Taneja, Kanumuri Siva Rama Raju, Jiaur Rahaman Gayen, Sheelendra Pratap Singh, Neelam S Sangwand, Muhammad Wahajuddin
Withanolides are the group of active chemical constituents of Withania somnifera (L.) Dunal. Withaferin A, withanolide A and withanone presents three of the biologically most active constituents of this herb. These steroidal lactones are isomers of each other and thus, pose significant difficulty in their separation. In present study, a simple, specific and reliable RP-HPLC method has been developed and validated for their separation and simultaneous quantification. Separation was carried out on Lichrocart Purospher STAR RP-18e column (250 × 4...
April 12, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28387788/facile-synthesis-and-chiral-separation-of-chiral-mesoporous-silica-microspheres
#3
Rui Wang, Hui Yang, Kunpeng Xue, Yuexing Zhao, Xingzhong Guo
Mesoporous silica microspheres were synthesized by an acid-catalyzed sol-gel method using tetraethoxysilane (TEOS) as a precursor. The hydrochloric acid was used as a catalyzer to induce the hydrolysis of TEOS, while the cyclohexane acted as a stabilizer of the sol. The addition of polyethylene glycol can introduce the uniform mesoporous structure into the microspheres by phase separation. The as-prepared mesoporous silica microspheres possess a narrow particle size distribution, a mesopore size of 5.0 nm and a Brunauer-Emmett-Teller specific surface area as high as 230 m2·g-1...
April 6, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28383683/validated-lc-ms-ms-method-for-determination-of-sf0034-in-mice-plasma-application-to-a-pharmacokinetic-study-in-mice
#4
Umesh Todmal, P S Suresh, Mohd Zainuddin, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Gurulingappa Hallur, Sridharan Rajagopal, Sriram Rajagopal, Ramesh Mullangi
A rapid and sensitive assay method has been developed and validated using liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode for the estimation of SF0034 in mice plasma. The assay procedure involves a simple protein precipitation of SF0034 and tolbutamide (internal standard, IS) from mice plasma. Chromatographic separation was performed on an Atlantis dC18 column using an isocratic mobile phase comprising 0.2% formic acid:acetonitrile (10:90, v/v) at a flow rate of 0...
April 5, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28383657/lc-ms-ms-determination-of-empagliflozin-and-metformin
#5
Bassam M Ayoub, Shereen Mowaka
A new LC-MS/MS method was developed for determination of empagliflozin and metformin. Bridged Ethylene Hybrid C18 column (50 mm × 2.1 mm, 1.7 μm), isocratic elution based on 0.1% aqueous formic acid:acetonitrile (75:25, v/v) as a mobile phase, column temperature at 55°C and flow rate at 0.2 mL min-1 were used. The mass spectrometer was operated under multiple reaction monitoring mode using electrospray ionization by monitoring the transition pairs (precursor to product ion) of m/z 451.04-71.07 for empagliflozin and m/z 130...
April 5, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28383651/chromatographic-enantioseparations-in-achiral-environments-myth-or-truth
#6
Jürgen Martens, Ravi Bhushan, Mieczyslaw Sajewicz, Teresa Kowalska
Direct chromatographic enantioseparations are among the most important practical tasks of chromatography. The accepted rules and concepts of stereochemistry anticipated one type of chromatographic systems applicable only to such enantioseparations consisting either of chiral stationary phase, or chiral selector present in mobile phase. In such a model of chromatographic system, both racemic and non-racemic mixtures could be enantioseparated. Over the years, however, reports on successful chiral enantioseparations in non-chiral chromatographic systems have cumulated as well...
April 5, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28369337/determination-of-bortezomib-in-api-samples-using-hplc-assessment-of-enantiomeric-and-diastereomeric-impurities
#7
Zahra Kamalzadeh, Esmaeil Babanezhad, Solmaz Ghaffari, Alireza Mohseni Ezhiyeh, Mahdieh Mohammadnejad, Mehdi Naghibfar, Morteza Bararjanian, Hossein Attar
A new, normal phase high performance liquid chromatography (NP-HPLC) method was developed for separation of Bortezomib (BZB) enantiomers and quantitative determination of (1S,2R)-enantiomer of BZB in active pharmaceutical ingredient (API) samples. The developed method was validated based on International Conference on Harmonisation (ICH) guidelines and it was proved to be accurate, precise and robust. The obtained resolution (RS) between the enantiomers was more than 2. The calibration curve for (1S,2R)-enantiomer was found to be linear in the concentration range of 0...
March 25, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28369274/simultaneous-determination-and-comparative-pharmacokinetics-of-fuzi-water-soluble-alkaloids-between-normal-and-acute-heart-failure-rats-by-ultra-performance-liquid-chromatography-method
#8
Yan Li, Yun-Xia Li, Jue Dang, Lin Luo, An Yuan, Meng-Jie Zhao, Xiao-Hong Gong, Cheng Peng
In order to compare the pharmacokinetics of Fuzi water-soluble alkaloids between normal and acute heart failure rats, an ultra performance liquid chromatography (UPLC) method for simultaneous determination of it in rat plasma was developed. Plasma samples were treated by protein precipitation method. Seven water-soluble alkaloids were separated on a CAPCELL column and detected under the optimized chromatography condition. The calibration curves of seven targeted components showed good linearity with r2 > 0...
March 24, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28369177/a-simple-and-direct-lc-ms-method-for-determination-of-genotoxic-impurity-hydroxylamine-in-pharmaceutical-compounds
#9
Thangarathinam Kumar, Mohandass Ramya, Viswanathan Srinivasan, N Xavier
Hydroxylamine is a known genotoxic impurity compound that needs to be controlled down to ppm level in pharmaceutical processes. It is difficult to detect using conventional analytical techniques due to its physio-chemical properties like lack of chromophore, low molecular weight, absence of carbon atom and high polarity. In addition to that, analysis of the pharmaceutical samples encounters considerable obstruction from matrix components that greatly overshadow the response of hydroxylamine. This study describes a simple, sensitive and direct Liquid Chromatographic-Mass Spectrometric method (LC-MS) for detection of hydroxylamine in pharmaceutical compounds...
March 21, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334920/spe-hplc-determination-of-chlorogenic-and-phenolic-acids-in-coffee
#10
Pelin Köseoglu Yilmaz, Ufuk Kolak
A new solid phase extraction-high-performance liquid chromatography method with ultraviolet detection was developed and validated for the determination of three chlorogenic acids (5-O-caffeoylquinic, 3-O-caffeoylquinic and 4-O-caffeoylquinic acids) and six phenolic acids (caffeic, ferulic, sinapic, protocatechuic, p-hydroxybenzoic acid (PHBA) and vanillic acid (VA)) in coffee bean samples. Extraction was performed using hydrophilic-lipophilic balance cartridges. Separations were accomplished using a C18 guard column (10 × 2...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334872/hplc-dad-fld-method-for-simultaneous-determination-of-mycotoxins-in-wheat-bran
#11
Maria N Irakli, Adriana Skendi, Maria D Papageorgiou
Aflatoxins, deoxynivalenol, ochratoxin A and zearalenone are the most important mycotoxins that everyone on its own, in groups or simultaneously contaminate cereals. The external layers of cereal grains (bran) apart from health promoting ingredients are also the most contaminated part with reference to mycotoxin's presence. Therefore, consumption of a high fiber wheat-based diet represent an increased risk to consumer's health. The objective of this study was to develop a simple and reliable high performance liquid chromatography method for the simultaneous determination of these mycotoxins in wheat bran (WB)...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334842/enhanced-hplc-dad-method-for-fast-determination-of-quercetin-3-o-%C3%AE-d-glucoside-in-extracts-and-polyherbal-formulations-containing-azadirachta-indica-optimization-and-validation
#12
Sonal Desai, Pratima Tatke, Satish Gabhe
Azadirachta indica has been used for its medicinal properties since time immemorial. Herbal medicines which are prepared using this medicinal tree are utilized to treat various diseases and disorders. No reports are available for marker-based standardization of these herbal medicines prepared from leaves of A. indica. Also existing HPLC methods for determination quercetin-3-O-β-d-glucoside are time consuming. There is an obvious need for development of new HPLC method for quantification of quercetin-3-O-β-d-glucoside which is fast enough to carry out analysis in stipulated time period...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334985/multicriteria-optimization-methodology-in-stability-indicating-method-development-of-cilazapril-and-hydrochlorothiazide
#13
Jasmina Šljivic, Ana Protic, Biljana Otaševic, Jelena Golubovic, Mira Zecevic, Jovana Krmar
Multicriteria optimization methodology was applied in development of UHPLC-UV-MS method for separation of cilazapril, hydrochlorothiazide and their degradation products. This method is also applicable for analysis of cilazapril, hydrochlorothiazide and their degradation products in combined tablet formulation. Prior to method optimization forced degradation studies were conducted. Cilazapril and hydrochlorothiazide were subjected to acidic (0.1, 0.5 and 1.0 M HCl), basic (0.1, 0.5 and 1.0 M NaOH), thermal (70°C), oxidative (3-30% H2O2) degradation and photodegradation (day light)...
March 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334929/large-scale-preparation-of-a-specific-xanthone-from-swertia-mussotii-and-evaluation-of-its-%C3%AE-glucosidase-inhibitory-activity
#14
Tao Chen, Hongmei Li, Chen Chen, Lixin Wei, Yulin Li
Large-scale preparation and α-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study. Firstly, an efficient method was successfully established by liquid-liquid extraction, preparative high-performance liquid chromatography and sephadex LH-20 for large-scale preparation of swertioside. The recovery of swertioside reached 92.0%. Secondly, in vitro α-glucosidase inhibition experiment showed that swertioside had good inhibition close to acarbose...
March 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334923/validated-rp-hplc-dad-method-for-the-quantification-of-insect-repellent-ethyl-2-aminobenzoate-in-membrane-moderated-matrix-type-monolithic-polymeric-device
#15
Johirul Islam, Kamaruz Zaman, Srijita Chakrabarti, Nilutpal Sharma Bora, Santa Mandal, Manash Pratim Pathak, Pakalapati Srinivas Raju, Pronobesh Chattopadhyay
A simple, accurate and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ethyl 2-aminobenzoate (EAB) in a matrix type monolithic polymeric device and validated as per the International Conference on Harmonization guidelines. The analysis was performed isocratically on a ZORBAX Eclipse plus C18 analytical column (250 × 4.4 mm, 5 μm) and a diode array detector (DAD) using acetonitrile and water (75:25 v/v) as the mobile phase by keeping the flow-rate constant at 1...
March 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334787/the-development-and-validation-of-novel-simple-high-performance-liquid-chromatographic-method-with-refractive-index-detector-for-quantification-of-memantine-hydrochloride-in-dissolution-samples
#16
Tukaram B Sawant, Vikas S Wakchaure, Udyakumar K Rakibe, Prashant B Musmade, Bhata R Chaudhari, Dhananjay V Mane
The present study was aimed to develop an analytical method for quantification of memantine (MEM) hydrochloride in dissolution samples using high-performance liquid chromatography with refractive index (RI) detector. The chromatographic separation was achieved on C18 (250 × 4.5 mm, 5 μm) column using isocratic mobile phase comprises of buffer (pH 5.2):methanol (40:60 v/v) pumped at a flow rate of 1.0 mL/min. The column effluents were monitored using RI detector. The retention time of MEM was found to be ~6...
March 4, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334987/magnetic-solid-phase-extraction-of-n-n-diethyl-m-toluamide-from-baby-toilet-water-prior-to-its-hplc-uv-detection
#17
Xiaowei Ma, Fan Feng, Yang Yang, Xueping Dang, Jianlin Huang, Huaixia Chen
Fe3O4@MIL-100 (MIL, Material Institut Lavoisier) core-shell magnetic microspheres were prepared and applied as the sorbent for the magnetic solid phase extraction (MSPE) of N,N-diethyl-m-toluamide (DEET) in baby toilet water for the first time. The synthesized magnetic metal-organic frameworks were characterized by transmission electron microscope, infrared spectroscopy and thermogravimetric analysis. The functionalized magnetic microparticles showed excellent dispersibility in aqueous solution. The MSPE conditions were investigated in detail...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334925/simultaneous-lc-ms-ms-determination-of-lopinavir-and-rifabutin-in-human-plasma
#18
Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Jawahar Lal
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is preferred over rifampicin in treatment of HIV and TB co-morbidity. A simple and specific liquid chromatography tandem mass spectrometry method was developed for quantification of rifabutin (RBT) and lopinavir (LPV) simultaneously in human plasma...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334890/application-of-ultrasound-assisted-surfactant-enhanced-emulsification-microextraction-based-on-solidi%C3%AF-cation-of-floating-organic-droplets-and-high-performance-liquid-chromatography-for-preconcentration-and-determination-of-alprazolam-and-chlordiazepoxide-in
#19
Nasser Goudarzi, Monavar Amirnavaee, Mansour Arab Chamjangali, Sahar Farsimadan
An improved microextraction method is proposed on the basis of ultrasound-assisted surfactant-enhanced emulsification and solidification of a floating organic droplet procedure combined with high performance liquid chromatography for the preconcentration and quantification of alprazolam (ALP) and chlordiazepoxide (CHL) present in a number of human serum samples. Several parameters affecting the extraction efficiency were investigated by the Plackett -Burman factorial design as the screening design. Then the response surface methodology based on the Box-Behnken design was used to optimize the effective parameters in the proposed procedure...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28335025/a-novel-lc-ms-ms-method-with-an-effective-antioxidant-for-the-determination-of-edaravone-a-free-radical-scavenger-in-dog-plasma-and-its-application-to-a-pharmacokinetic-study
#20
Feng Shao, Xiao-Ling Hu, Xin Liu, Mang-Ting Shan
The objective of this study was to investigate the stability of edaravone in dog plasma by using an added antioxidant stabilizer, with an ultimate goal of developing and validating a sensitive, reliable and robust LC-MS-MS method for determination of edaravone in plasma samples. Edaravone was unstable in plasma, but it presented a good stability performance in the plasma with sodium metabisulfite (SMB), an effective antioxidant. The blood sample was collected in the heparinized eppendorf tube containing SMB and plasma sample was deproteinized using acetonitrile containing 20 ng/mL of phenacetin (Internal standard)...
March 2, 2017: Journal of Chromatographic Science
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