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Journal of Chromatographic Science

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https://www.readbyqxmd.com/read/28334920/spe-hplc-determination-of-chlorogenic-and-phenolic-acids-in-coffee
#1
Pelin Köseoglu Yilmaz, Ufuk Kolak
A new solid phase extraction-high-performance liquid chromatography method with ultraviolet detection was developed and validated for the determination of three chlorogenic acids (5-O-caffeoylquinic, 3-O-caffeoylquinic and 4-O-caffeoylquinic acids) and six phenolic acids (caffeic, ferulic, sinapic, protocatechuic, p-hydroxybenzoic acid (PHBA) and vanillic acid (VA)) in coffee bean samples. Extraction was performed using hydrophilic-lipophilic balance cartridges. Separations were accomplished using a C18 guard column (10 × 2...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334872/hplc-dad-fld-method-for-simultaneous-determination-of-mycotoxins-in-wheat-bran
#2
Maria N Irakli, Adriana Skendi, Maria D Papageorgiou
Aflatoxins, deoxynivalenol, ochratoxin A and zearalenone are the most important mycotoxins that everyone on its own, in groups or simultaneously contaminate cereals. The external layers of cereal grains (bran) apart from health promoting ingredients are also the most contaminated part with reference to mycotoxin's presence. Therefore, consumption of a high fiber wheat-based diet represent an increased risk to consumer's health. The objective of this study was to develop a simple and reliable high performance liquid chromatography method for the simultaneous determination of these mycotoxins in wheat bran (WB)...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334842/enhanced-hplc-dad-method-for-fast-determination-of-quercetin-3-o-%C3%AE-d-glucoside-in-extracts-and-polyherbal-formulations-containing-azadirachta-indica-optimization-and-validation
#3
Sonal Desai, Pratima Tatke, Satish Gabhe
Azadirachta indica has been used for its medicinal properties since time immemorial. Herbal medicines which are prepared using this medicinal tree are utilized to treat various diseases and disorders. No reports are available for marker-based standardization of these herbal medicines prepared from leaves of A. indica. Also existing HPLC methods for determination quercetin-3-O-β-d-glucoside are time consuming. There is an obvious need for development of new HPLC method for quantification of quercetin-3-O-β-d-glucoside which is fast enough to carry out analysis in stipulated time period...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334985/multicriteria-optimization-methodology-in-stability-indicating-method-development-of-cilazapril-and-hydrochlorothiazide
#4
Jasmina Šljivic, Ana Protic, Biljana Otaševic, Jelena Golubovic, Mira Zecevic, Jovana Krmar
Multicriteria optimization methodology was applied in development of UHPLC-UV-MS method for separation of cilazapril, hydrochlorothiazide and their degradation products. This method is also applicable for analysis of cilazapril, hydrochlorothiazide and their degradation products in combined tablet formulation. Prior to method optimization forced degradation studies were conducted. Cilazapril and hydrochlorothiazide were subjected to acidic (0.1, 0.5 and 1.0 M HCl), basic (0.1, 0.5 and 1.0 M NaOH), thermal (70°C), oxidative (3-30% H2O2) degradation and photodegradation (day light)...
March 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334929/large-scale-preparation-of-a-specific-xanthone-from-swertia-mussotii-and-evaluation-of-its-%C3%AE-glucosidase-inhibitory-activity
#5
Tao Chen, Hongmei Li, Chen Chen, Lixin Wei, Yulin Li
Large-scale preparation and α-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study. Firstly, an efficient method was successfully established by liquid-liquid extraction, preparative high-performance liquid chromatography and sephadex LH-20 for large-scale preparation of swertioside. The recovery of swertioside reached 92.0%. Secondly, in vitro α-glucosidase inhibition experiment showed that swertioside had good inhibition close to acarbose...
March 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334923/validated-rp-hplc-dad-method-for-the-quantification-of-insect-repellent-ethyl-2-aminobenzoate-in-membrane-moderated-matrix-type-monolithic-polymeric-device
#6
Johirul Islam, Kamaruz Zaman, Srijita Chakrabarti, Nilutpal Sharma Bora, Santa Mandal, Manash Pratim Pathak, Pakalapati Srinivas Raju, Pronobesh Chattopadhyay
A simple, accurate and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ethyl 2-aminobenzoate (EAB) in a matrix type monolithic polymeric device and validated as per the International Conference on Harmonization guidelines. The analysis was performed isocratically on a ZORBAX Eclipse plus C18 analytical column (250 × 4.4 mm, 5 μm) and a diode array detector (DAD) using acetonitrile and water (75:25 v/v) as the mobile phase by keeping the flow-rate constant at 1...
March 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334787/the-development-and-validation-of-novel-simple-high-performance-liquid-chromatographic-method-with-refractive-index-detector-for-quantification-of-memantine-hydrochloride-in-dissolution-samples
#7
Tukaram B Sawant, Vikas S Wakchaure, Udyakumar K Rakibe, Prashant B Musmade, Bhata R Chaudhari, Dhananjay V Mane
The present study was aimed to develop an analytical method for quantification of memantine (MEM) hydrochloride in dissolution samples using high-performance liquid chromatography with refractive index (RI) detector. The chromatographic separation was achieved on C18 (250 × 4.5 mm, 5 μm) column using isocratic mobile phase comprises of buffer (pH 5.2):methanol (40:60 v/v) pumped at a flow rate of 1.0 mL/min. The column effluents were monitored using RI detector. The retention time of MEM was found to be ~6...
March 4, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334987/magnetic-solid-phase-extraction-of-n-n-diethyl-m-toluamide-from-baby-toilet-water-prior-to-its-hplc-uv-detection
#8
Xiaowei Ma, Fan Feng, Yang Yang, Xueping Dang, Jianlin Huang, Huaixia Chen
Fe3O4@MIL-100 (MIL, Material Institut Lavoisier) core-shell magnetic microspheres were prepared and applied as the sorbent for the magnetic solid phase extraction (MSPE) of N,N-diethyl-m-toluamide (DEET) in baby toilet water for the first time. The synthesized magnetic metal-organic frameworks were characterized by transmission electron microscope, infrared spectroscopy and thermogravimetric analysis. The functionalized magnetic microparticles showed excellent dispersibility in aqueous solution. The MSPE conditions were investigated in detail...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334925/simultaneous-lc-ms-ms-determination-of-lopinavir-and-rifabutin-in-human-plasma
#9
Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Jawahar Lal
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is preferred over rifampicin in treatment of HIV and TB co-morbidity. A simple and specific liquid chromatography tandem mass spectrometry method was developed for quantification of rifabutin (RBT) and lopinavir (LPV) simultaneously in human plasma...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334890/application-of-ultrasound-assisted-surfactant-enhanced-emulsification-microextraction-based-on-solidi%C3%AF-cation-of-floating-organic-droplets-and-high-performance-liquid-chromatography-for-preconcentration-and-determination-of-alprazolam-and-chlordiazepoxide-in
#10
Nasser Goudarzi, Monavar Amirnavaee, Mansour Arab Chamjangali, Sahar Farsimadan
An improved microextraction method is proposed on the basis of ultrasound-assisted surfactant-enhanced emulsification and solidification of a floating organic droplet procedure combined with high performance liquid chromatography for the preconcentration and quantification of alprazolam (ALP) and chlordiazepoxide (CHL) present in a number of human serum samples. Several parameters affecting the extraction efficiency were investigated by the Plackett -Burman factorial design as the screening design. Then the response surface methodology based on the Box-Behnken design was used to optimize the effective parameters in the proposed procedure...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28335025/a-novel-lc-ms-ms-method-with-an-effective-antioxidant-for-the-determination-of-edaravone-a-free-radical-scavenger-in-dog-plasma-and-its-application-to-a-pharmacokinetic-study
#11
Feng Shao, Xiao-Ling Hu, Xin Liu, Mang-Ting Shan
The objective of this study was to investigate the stability of edaravone in dog plasma by using an added antioxidant stabilizer, with an ultimate goal of developing and validating a sensitive, reliable and robust LC-MS-MS method for determination of edaravone in plasma samples. Edaravone was unstable in plasma, but it presented a good stability performance in the plasma with sodium metabisulfite (SMB), an effective antioxidant. The blood sample was collected in the heparinized eppendorf tube containing SMB and plasma sample was deproteinized using acetonitrile containing 20 ng/mL of phenacetin (Internal standard)...
March 2, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334796/determination-of-meloxicam-in-egg-whites-and-yolks-using-reverse-phase-chromatography
#12
Sherry Cox, Joan Bailey, Molly White, Kristen Gordon, Marcy Souza
A new method of analysis has been developed and validated for the determination of meloxicam in egg whites and yolks. Following a liquid extraction for the whites and a solid phase extraction for the yolks, samples were separated on an XBridge C18 column and quantified using ultraviolet detection at 360 nm. The mobile phase was a mixture of water with glacial acetic acid and acetonitrile, with a flow rate of 1 mL/min. The procedure produced a linear graph over the concentration range 5-1500 ng/mL with a lower limit of quantification of 5 ng/mL...
March 2, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28335023/qbd-driven-development-and-validation-of-liquid-chromatography-tandem-mass-spectrometric-method-for-the-quantitation-of-sildenafil-in-human-plasma
#13
M Saquib Hasnain, Shaukat Ali Ansari, Shireen Rao, Mohammad Tabish, Mukul Singh, Mohammad Syafiq Abdullah, Mohammed Tahir Ansari
The present work was employing the Quality by Design approach for the development and validation of a LC-MS-MS method to support the clinical advancement in determination of sildenafil in human plasma using lorazepam as an internal standard. Sample preparation involved solid phase extraction and calibration range observed between 3 and 1,700 ng/mL. The method was systematically optimized by employing Box-Behnken design and used mobile phase flow rate, pH and composition of mobile phase as the critical factors, and assessing the design for retention time and peak area as the responses...
February 27, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334778/exploration-of-deep-eutectic-solvent-based-molecularly-imprinted-polymers-as-solid-phase-extraction-sorbents-for-screening-chloramphenicol-in-milk
#14
Weiyang Tang, Fan Gao, Yue Duan, Tao Zhu, Kyung Ho Row
Novel deep eutectic solvents modified molecularly imprinted polymers (DESs-MIPs) were synthesized using acrylamide as function monomer, alcohol-based DESs as auxiliary function monomer and chloramphenicol (CAP) as the template. The DESs modified materials were characterized by Fourier transform infrared and field emission scanning electron microscope. The adsorption results that the choline chloride/ethylene glycol DESs-based MIPs had stable interactions with CAP. So the choline chloride/ethylene glycol DESs-based MIPs were applied as sorbent of minimized pipette-tip solid-phase extraction (PT-SPE) for rapid screening CAP from milk sample...
February 27, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334752/monitoring-the-consistency-quality-and-antioxidant-activity-of-da-hong-pao-teas-by-hplc-fingerprinting
#15
Lin Wang, Ting Yan, Lanping Yang, Kexia Zhang, Jingming Jia
In the present study, a high performance liquid chromatography (HPLC) method was developed and validated for fingerprint profiling to evaluate the quality consistency of the Da Hong Pao tea. The chromatographic separation was performed on a USA Waters C18 column (4.6 mm × 250 mm, 5 μm, Waters-XBridge Shield RP 18) with gradient elution. The column temperature was maintained at 30°C and the detection wavelength was set at 278 nm. The results demonstrated that the developed HPLC method achieved the desired linearity, precision, accuracy and limit of quantification...
February 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28203809/a-tlc-direct-bioautography-method-for-detection-of-antiurolithiatic-metabolites
#16
Anita Surendra Patil, Hariprasad Madhukarrao Paikrao, Ankit Subhash Kale, Surendra Raghoba Manik
No abstract text is available yet for this article.
February 16, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28203774/novel-chromatographic-methods-for-simultaneous-quantification-of-fish-and-wheat-germ-oils-mixture-in-pharmaceutical-dosage-forms
#17
Amira F El-Yazbi, Amr El-Hawiet
No abstract text is available yet for this article.
February 16, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28203764/two-dimensional-model-for-reactive-sorption-columns-of-cylindrical-geometry-analytical-solutions-and-moment-analysis
#18
Farman U Khan, Shamsul Qamar
No abstract text is available yet for this article.
February 16, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28203760/determination-of-alkaloid-contents-in-various-tissues-of-coptis-chinensis-franch-by-reversed-phase-high-performance-liquid-chromatography-and-ultraviolet-spectrophotometry
#19
Yanfang Yang, Jingling Peng, Fangping Li, Xin Liu, Meng Deng, Hezhen Wu
No abstract text is available yet for this article.
February 16, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28203815/determination-of-escitalopram-oxalate-and-l-methylfolate-in-tablet-by-spectrophotometric-and-reverse-phase-high-performance-liquid-chromatographic-methods
#20
Seema Sheladia, Bhavesh Patel
No abstract text is available yet for this article.
February 14, 2017: Journal of Chromatographic Science
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