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Microvascular Research

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https://www.readbyqxmd.com/read/28625890/acute-effects-of-coffee-on-skin-blood-flow-and-microvascular-function
#1
Erik Tesselaar, Dzeneta Nezirevic Dernroth, Simon Farnebo
OBJECTIVE: Studies on the acute effects of coffee on the microcirculation have shown contradicting results. This study aimed to investigate if intake of caffeine-containing coffee changes blood flow and microvascular reactivity in the skin. METHODS: We measured acute changes in cutaneous vascular conductance (CVC) in the forearm and the tip of the finger, the microvascular response to transdermal iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) and post-occlusive reactive hyperemia (PORH) in the skin, after intake of caffeinated or decaffeinated coffee...
June 15, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28619665/computer-modelling-of-electro-osmotically-augmented-three-layered-microvascular-peristaltic-blood-flow
#2
Dharmendra Tripathi, Abhilesh Borode, Ravinder Jhorar, O Anwar Bég, Abhishek Kumar Tiwari
A theoretical study is presented here for the electro-osmosis modulated peristaltic three-layered capillary flow of viscous fluids with different viscosities in the layers. The layers considered here are the core layer, the intermediate layer and the peripheral layer. The analysis has been carried out under a number of physical restrictions viz. Debye-Hückel linearization (i.e. wall zeta potential ≤25mV) is assumed sufficiently small, thin electric double layer limit (i.e. the peripheral layer is much thicker than the electric double layer thickness), low Reynolds number and large wavelength approximations...
June 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28619664/nailfold-capillaroscopic-changes-in-patients-with-idiopathic-pulmonary-arterial-hypertension-and-systemic-sclerosis-related-pulmonary-arterial-hypertension
#3
A Corrado, M Correale, N Mansueto, I Monaco, A Carriero, A Mele, R Colia, M Di Biase, F P Cantatore
Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in systemic sclerosis (SSc). Lung microvascular changes can play a role in the pathogenesis of idiopathic PAH (IPAH) also. The aim of this study is to investigate the presence of capillaroscopic abnormalities in patients with IPAH and to evaluate the differences in capillary nailfold changes between patients with IPAH and patients with SSc with and without PAH. METHODS: 39 SSc patients (19 with PAH - SSc-PAH and 20 without - SSc-noPAH), 21 subjects with IPAH and 20 healthy subjects were recruited...
June 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28602918/angiogenic-and-angiostatic-factors-in-renal-scleroderma-associated-vasculopathy
#4
Antonietta Gigante, Navarini Luca, Margiotta Domenico, Amoroso Antonio, Barbano Biagio, Cianci Rosario, Afeltra Antonella, Rosato Edoardo
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters...
June 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28595801/deregulation-of-hsa-mir-20b-expression-in-tnf-%C3%AE-induced-premature-senescence-of-human-pulmonary-microvascular-endothelial-cells
#5
Pooi-Fong Wong, Juliana Jamal, Kind-Leng Tong, Eng-Soon Khor, Chia-Earn Yeap, Hui-Lan Jong, Sui-Ting Lee, Mohd Rais Mustafa, Sazaly Abubakar
miRNAs are important regulators of cellular senescence yet the extent of their involvement remains to be investigated. We sought to identify miRNAs that are involved in cytokine-induced premature senescence (CIPS) in endothelial cells. CIPS was established in young human pulmonary microvascular endothelial cells (HMVEC-Ls) following treatment with a sublethal dose (20ng/ml) of tumor necrosis factor alpha (TNF-α) for 15days. In parallel, HMVEC-Ls were grown and routinely passaged until the onset of replicative senescence (RS)...
June 5, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28587989/hypertension-alters-the-endothelial-dependent-biphasic-response-of-bradykinin-in-isolated-microminipig-basilar-artery
#6
Md Zahorul Islam, Hiroaki Kawaguchi, Naoki Miura, Noriaki Miyoshi, Emi Yamazaki-Himeno, Mitsuya Shiraishi, Atsushi Miyamoto, Akihide Tanimoto
Angiotensin (Ang) II is known to promote vascular disease and hypertension, partly through its effect on vascular endothelium. Bradykinin (BK) is an endothelium-dependent agonist that induces relaxation followed by contraction of the porcine basilar artery through release of NO and PGF2α, respectively. In this study, we evaluated the effect of Ang II-induced hypertension on basilar artery responsiveness to BK in the Microminipig (MMPig). Ang II (200ng/kg/min) or vehicle was infused into MMPigs for 14days using an osmotic mini-pump and blood pressure was monitored regularly...
June 3, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28579512/homocysteine-up-regulates-endothelin-type-a-receptor-in-vascular-smooth-muscle-cells-through-sirt1-erk1-2-signaling-pathway
#7
Yulong Chen, Huanhuan Liu, Xinhong Wang, Hongmei Zhang, Enqi Liu, Xingli Su
Sirtuin 1 (Sirt1) is a longevity gene that has protective effects in cardiovascular diseases (CVDs). The endothelin type A (ETA) receptor is involved in pathogenesis of CVDs. The extracellular signal related kinases 1 and 2 (ERK1/2) signaling pathway is involved in regulation of the ETA receptor induced by some CVD risk factors in vascular smooth muscle cells (VSMCs). Hyperhomocysteinemia (HHcy) is an independent risk factor for CVDs. The present study was designed to investigate the hypothesis that homocysteine up-regulates ETA receptor through the Sirt1/ERK1/2 signaling pathway...
June 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28571890/a-clinical-method-for-quantification-of-tissue-microvascular-blood-perfusion-in-absolute-terms-blood-volume-time%C3%A2-tissue-area
#8
Robert W Flower, Ronn Kling
Fluorescence-mediated photoplethysmography (FM-PPG) was developed to facilitate determination of tissue microvascular (capillary) blood perfusion, requiring intra-venous injection of a small bolus (~0.33mL) of dye (25mg/mL ICG) and acquisition of high-speed angiogram images (>15images/s). The methodology is applicable to microvascular capillary beds of tissues that can be optically imaged, directly or laparoscopically. Proof of concept of the methodology and feasibility of its implementation are demonstrated in human forearm skin and in the choroid of a monkey eye, determined to have blood perfusion rates on the order of 1e-5mL/(s·mm(2)) and 10e-5mL/(s·mm(2)), respectively...
May 29, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28549566/asymmetrical-responses-of-skin-blood-flow-in-ischemic-hindlimbs-to-electrical-stimulation-of-the-unilateral-forelimb
#9
Chung-Shin Huang, Ya-Hui Sun, Yi-Ting Wang, Yu-Hung Pan, Shwu-Fen Wang, Yuan-Feen Tsai
The regulation of skin blood flow (SBF) is primarily mediated by the sympathetic nervous system, but the effects of electrical stimulation (ES) of one limb on SBF in the other limbs remain unknown. The present study investigated the effects of unilateral forelimb ES on SBF in the bilateral hindlimbs in anesthetized rats. Bilateral hindlimb ischemia was induced by tourniquet application for 60min. After reperfusion for 24h, ES (3 or 125Hz) was applied to the upper one-fourth of the triceps brachii muscle of the left or right forelimb for 30min...
May 23, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28546078/doxycycline-affects-gene-expression-profiles-in-aortic-tissues-in-a-rat-model-of-vascular-calcification
#10
Hailin Lu, Wenhong Jiang, Han Yang, Zhong Qin, Si-En Guo, Ming Hu, Xiao Qin
Vitamin D3-induced vascular calcification (VC) in rats shares many phenotypical similarities with calcification occurring in human atherosclerosis, diabetes mellitus and chronic kidney disease, thereby it is a reliable model for identifying chemopreventive agents. Doxycycline has been shown to effectively attenuated VC. This study aimed to explore the effects of doxycycline on gene expression profiles in VC rats. The model of VC in rats was established by subcutaneous injection of vitamin D3 for 3days. Doxycycline at 120mgkg(-1)day(-1) was given via subcutaneous injection for 14days...
May 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28546077/systemic-administration-of-l-kynurenine-sulfate-induces-cerebral-hypoperfusion-transients-in-adult-c57bl-6-mice
#11
Dániel Péter Varga, Ákos Menyhárt, Tamás Puskás, Ferenc Bari, Eszter Farkas, Zsolt Kis, László Vécsei, József Toldi, Levente Gellért
The kynurenine pathway is a cascade of enzymatic steps generating biologically active compounds. l-kynurenine (l-KYN) is a central metabolite of tryptophan degradation. In the mammalian brain, l-KYN is partly converted to kynurenic acid (KYNA), which exerts multiple effects on neurotransmission. Recently, l-KYN or one of its derivatives were attributed a direct role in the regulation of the systemic circulation. l-KYN dilates arterial blood vessels during sepsis in rats, while it increases cerebral blood flow (CBF) in awake rabbits...
May 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28546076/sirna-knockdown-of-adamts-13-modulates-endothelial-cell-angiogenesis
#12
Huiyuan Tang, Manfai Lee, Eun Ho Kim, Daniel Bishop, George M Rodgers
ADAMTS-13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13, is a zinc-containing metalloprotease that cleaves von Willebrand factor (vWf). Previous publications by our laboratory have shown that ADAMTS-13 may also be involved in angiogenesis. For this study, we report the successful transient knockdown of endogenous ADAMTS-13 in human umbilical vein endothelial cells (HUVEC) via siRNA and the effects of reduced endogenous ADAMTS-13 on HUVEC angiogenesis functions. 15nM of ADAMTS-13 siRNA reduced HUVEC ADAMTS-13 protein levels by 90% after 24h incubation, whereas control siRNA did not affect endogenous ADAMTS-13 levels...
May 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28529172/contribution-of-muscarinic-receptors-to-in-vitro-and-in-vivo-effects-of-ruscus-extract
#13
Isabelle Rauly-Lestienne, Peter Heusler, Didier Cussac, Frédérique Lantoine-Adam, Fatima Zely Garcia de Almeida Cyrino, Eliete Bouskela
The objectives of this study were to evaluate, in vitro and in vivo, the contribution of muscarinic receptors to the effects of Ruscus extract. Ruscus extract was tested in competition binding experiments at recombinant human muscarinic receptors, heterologous expressed in Chinese Hamster Ovary (CHO) cells and in cellular assays measuring Ca(2+) liberation and activator protein-1 (AP-1) reporter gene activation. The impact of muscarinic blockade on prolonged treatment outcome was evaluated using the hamster cheek pouch (HCP) microcirculation examining macromolecular permeability increase induced by histamine or ischemia/reperfusion (I/R), mean arteriolar and venular diameters, functional capillary density and I/R-induced leukocyte rolling and sticking...
May 19, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28529171/reproducibility-of-flow-mediated-skin-fluorescence-to-assess-microvascular-function
#14
Marcin Hellmann, Maria Tarnawska, Maria Dudziak, Karolina Dorniak, Matthieu Roustit, Jean-Luc Cracowski
OBJECTIVE: Recent technical developments enable skin fluorescence to be quantified in vivo in humans. The present study aimed at determining whether flow mediated skin fluorescence was reproducible, sensitive to changes within an individual, and if it could differ between patients with coronary artery disease and healthy volunteers. METHODS: First, forearm flow mediated skin fluorescence recorded during and after brachial artery occlusion was assessed following successive forearm occlusion periods (1, 2, 3 and 5min) and expressed as ischemic and hyperemic responses (as % of baseline)...
May 18, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28495471/quantitative-outcome-measures-for-systemic-sclerosis-related-microangiopathy-reliability-of-image-acquisition-in-nailfold-capillaroscopy
#15
Graham Dinsdale, Tonia Moore, Neil O'Leary, Michael Berks, Christopher Roberts, Joanne Manning, John Allen, Marina Anderson, Maurizio Cutolo, Roger Hesselstrand, Kevin Howell, Carmen Pizzorni, Vanessa Smith, Alberto Sulli, Marie Wildt, Christopher Taylor, Andrea Murray, Ariane L Herrick
BACKGROUND: Nailfold capillaroscopic parameters hold increasing promise as outcome measures for clinical trials in systemic sclerosis (SSc). Their inclusion as outcomes would often naturally require capillaroscopy images to be captured at several time points during any one study. Our objective was to assess repeatability of image acquisition (which has been little studied), as well as of measurement. METHOD: 41 patients (26 with SSc, 15 with primary Raynaud's phenomenon) and 10 healthy controls returned for repeat high-magnification (300×) videocapillaroscopy mosaic imaging of 10 digits one week after initial imaging (as part of a larger study of reliability)...
May 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28495449/peripheral-circulatory-disorders-in-essential-thrombocythemia
#16
Rafał Małecki, Małgorzata Gacka, Żanna Fiodorenko-Dumas, Ilias Dumas, Jacek Kwiatkowski, Rajmund Adamiec, Małgorzata Kuliszkiewicz-Janus
A significant amount of patients with essential thrombocythemia (ET) complain of symptoms including distal parts of the extremities (e.g., paresthesias or Raynaud's phenomenon). The aim of the present study was to examine peripheral circulation in the upper extremities of individuals with ET. The study included 45 ET patients and 30 control subjects. All participants were subjected to thermography, photoplethysmography, impedance plethysmography, and applanation tonometry pulse wave analysis. The patients with ET differed significantly from the control subjects in terms of 3rd finger skin temperature (mean 31...
May 7, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28478072/modeling-of-pulsatile-flow-dependent-nitric-oxide-regulation-in-a-realistic-microvascular-network
#17
Ruofan Wang, Qing Pan, Wolfgang M Kuebler, John K-J Li, Axel R Pries, Gangmin Ning
Hemodynamic pulsatility has been reported to regulate microcirculatory function. To quantitatively assess the impact of flow pulsatility on the microvasculature, a mathematical model was first developed to simulate the regulation of NO production by pulsatile flow in the microcirculation. Shear stress and pressure pulsatility were selected as regulators of endothelial NO production and NO-dependent vessel dilation as feedback to control microvascular hemodynamics. The model was then applied to a real microvascular network of the rat mesentery consisting of 546 microvessels...
May 3, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28457877/assessing-cutaneous-microvascular-function-with-iontophoresis-avoiding-non-specific-vasodilation
#18
Jordan Loader, Matthieu Roustit, Frances Taylor, Richard J MacIsaac, Simon Stewart, Christian Lorenzen, Guillaume Walther
AIM: Iontophoresis of vasoactive agents is commonly used to assess cutaneous microvascular reactivity. However, it is known that iontophoresis can be limited by confounding non-specific vasodilatory effects. Despite this, there is still no standardization of protocols or data expression. Therefore, this study evaluated commonly used protocols of iontophoresis by assessing each for evidence of non-specific vasodilatory effects and examined the reproducibility of those protocols that are free of non-specific responses...
April 28, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28455225/temporal-and-spatiotemporal-variability-in-comprehensive-forearm-skin-microcirculation-assessment-during-occlusion-protocols
#19
Tomas Strömberg, Folke Sjöberg, Sara Bergstrand
Forearm skin hyperemia during release after brachial occlusion has been proposed for evaluating peripheral arterial disease and endothelial dysfunction. We used a novel fiberoptic system integrating Laser Doppler Flowmetry and Diffuse Reflectance Spectroscopy for a comprehensive pointwise model based microcirculation characterization. The aim was to evaluate and compare the temporal and the spatiotemporal variabilities in forearm skin microcirculation parameters (speed resolved perfusion; low speed <1mm/s, PerfSR, <1; mid-speed 1-10mm/s, high speed >10mm/s, and total perfusion (PerfSR, tot); the concentration and oxygenation of red blood cells, CRBC and SO2)...
April 26, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28450106/detection-of-early-endothelial-damage-in-patients-with-raynaud-s-phenomenon
#20
Roberta Gualtierotti, Francesca Ingegnoli, Samantha Griffini, Elena Grovetti, Maria Orietta Borghi, Paolo Bucciarelli, Pier Luigi Meroni, Massimo Cugno
OBJECTIVES: Raynaud's phenomenon (RP) can be the first manifestation of systemic sclerosis (SSc) or other connective tissue diseases (CTDs), often preceding an overt disease by years. It is not known if markers of endothelial damage are detectable in those RP patients who subsequently develop a CTD. METHODS: We studied 82 RP patients at their first evaluation to correlate the levels of endothelial markers with the subsequent development of an overt disease 36months later...
April 25, 2017: Microvascular Research
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