journal
MENU ▼
Read by QxMD icon Read
search

Microvascular Research

journal
https://www.readbyqxmd.com/read/29325705/intra-test-and-test-retest-reliability-of-exercise-oximetry-in-arterial-claudication
#1
S Henni, Y W Semporé, T Le Meliner, N Ouedraogo, J-F Hamel, P Abraham
BACKGROUND: Transcutaneous oxygen pressure (tcpO2) reliability is blunted by an unpredictable transcutaneous gradient through the skin. We hypothesized that the "Decrease from Rest of Oxygen pressure (DROP: subtraction of limb-changes from chest-changes from the respective starting values) would show a good to excellent reliability during Exercise -tcpO2 investigations. METHODS: In three different experiments we tested: The intra-test variability at the peripheral level (Experiment A: 32 patients, 16 at each location), at the chest level (Experiment B: 45 patients) and the test-retest reproducibility within 3 months (Experiment C: 67 patients)...
January 8, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29307595/hyperglycemia-induced-early-growth-response-1-regulates-vascular-dysfunction-in-human-retinal-endothelial-cells
#2
Gayathree Karthikkeyan, Nareshkumar Ragavachetty Nagaraj, Aberami Seeneevasan, Sulochana Konerirajapuram Natarajan, Srinivasan Vedantham, Karunakaran Coral
Early growth response-1 (Egr-1) protein upregulation is reported in diabetes and vascular disorders. This study aims at deciphering its role in hyperglycemia induced changes of retinal endothelium. Human retinal endothelial cells (hRECs) were exposed to hyperglycemia (25mM) and normoglycemia (5.5mM). Gene silencing was done using siRNA against Egr-1. Transcript and protein level analysis of Egr-1 and gene targets were done using qPCR and immunoblotting respectively in hRECs, diabetic and nondiabetic human retina and immunofluorescence for localization in retinal sections...
January 4, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29305878/study-of-microvascular-non-newtonian-blood-flow-modulated-by-electroosmosis
#3
Dharmendra Tripathi, Ashu Yadav, O Anwar Bég, Rakesh Kumar
An analytical study of microvascular non-Newtonian blood flow is investigated in presence of electro-osmosis phenomenon. Blood is considered as a Bingham rheological aqueous ionic solutions. An externally applied static axial electrical field is imposed on the system. The Poisson-Boltzmann equation for electric potential distribution is implemented to accommodate the electrical double layer in the microvascular. With long wavelength, lubrication and Debye-Hückel approximations, the boundary value problem is rendered non-dimensional...
January 3, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29291432/joule-heating-and-zeta-potential-effects-on-peristaltic-blood-flow-through-porous-micro-vessels-altered-by-electrohydrodynamic
#4
N K Ranjit, G C Shit, D Tripathi
In most of the medical therapies, electromagnetic field plays important role to modulate the blood flow and to reduce the pain of human body. With this fact, this paper presents a mathematical model to study the peristaltic blood flow through porous microvessels in presence of electrohydrodynamics. The effects of Joule heating and different zeta potential are also considered. Darcy law is employed for porous medium. The mathematical analysis is carried out in the form of electroosmosis, flow analysis and heat transfer analysis...
December 29, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29247720/voltage-gated-potassium-channels-and-nos-contribute-to-a-sustained-cutaneous-vasodilation-elicited-by-local-heating-in-an-interactive-manner-in-young-adults
#5
Naoto Fujii, Lyra Halili, Takeshi Nishiyasu, Glen P Kenny
Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested the hypothesis that voltage-gated potassium (Kv) channels contribute to the plateau of the cutaneous vasodilation during local heating through NOS-dependent mechanisms. Eleven young males (25±4years) participated in this study wherein cutaneous vascular conductance (CVC) was measured at four intradermal microdialysis sites that were continuously perfused with either 1) lactated Ringer (Control), 2) 10mM 4-aminopyridine (Kv channel blocker), 3) 10mM Nω-Nitro-L-arginine (NOS inhibitor), or 4) a combination of 4-aminopyridine and Nω-Nitro-L-arginine...
December 13, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29247719/developmental-changes-of-l-arginine-transport-at-the-blood-brain-barrier-in-rats
#6
Masanori Tachikawa, Shirou Hirose, Shin-Ichi Akanuma, Ryo Matsuyama, Ken-Ichi Hosoya
l-Arginine is required for regulating synapse formation/patterning and angiogenesis in the developing brain. We hypothesized that this requirement would be met by increased transporter-mediated supply across the blood-brain barrier (BBB). Thus, the purpose of this work was to test the idea that elevation of blood-to-brain l-arginine transport across the BBB in the postnatal period coincides with up-regulation of cationic acid transporter 1 (CAT1) expression in developing brain capillaries. We found that the apparent brain-to-plasma concentration ratio (Kp, app) of l-arginine after intravenous administration during the first and second postnatal weeks was 2-fold greater than that at the adult stage...
December 13, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29247718/important-signals-regulating-coronary-artery-angiogenesis
#7
REVIEW
Sara Shoeibi, Paul Mozdziak, Shabnam Mohammadi
Angiogenesis is a complex process of budding, the formation of new blood vessels from pre-existing microvessels, via migration, proliferation and survival. Vascular angiogenesis factors include different classes of molecules that have a fundamental role in blood vessel formation. Numerous inducers of angiogenesis, such as the members of the vascular endothelial growth factor (VEGF) family, basic fibroblast growth factor (bFGF), angiopoietin (Ang), hepatocyte growth factor (HGF), and hypoxia inducible factor-1 (HIF-1), have an important role in angiogenesis...
December 13, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29203235/sensibility-and-specificity-of-laser-speckle-contrast-imaging-according-to-endo-pat-index-in-type-1-diabetes
#8
Alessandra S de M Matheus, Maria de Fátima Bevilacqua da Matta, Eliete Leão Silva Clemente, Maria de Lourdes Guimarães Rodrigues, Débora Cristina Torres Valença, Marília B Gomes
OBJECTIVES: To find out an normality value for microvascular response (physiological and pharmacological) assessed through laser speckle contrast imaging (LSCI) based on Endo-PAT, which identifies the ones with Endothelial Dysfunction (ED) in patients with Type 1 Diabetes (T1D). METHODS: Patients with T1D, aged ≥12years underwent a clinical-epidemiological questionnaire. Fasting blood samples were obtained (lipid profile, glycemic control and levels of C-reactive protein)...
December 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#9
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
November 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29107094/hyperspectral-imaging-for-monitoring-of-perfusion-failure-upon-microvascular-anastomosis-in-the-rat-hind-limb
#10
Eberhard Grambow, Michael Dau, Amadeus Holmer, Vicky Lipp, Bernhard Frerich, Ernst Klar, Brigitte Vollmar, Peer Wolfgang Kämmerer
BACKGROUND/PURPOSE: Objective, reliable and easy monitoring of microvascular tissue perfusion is a goal that was achieved for many years with limited success. Therefore, a new non-invasive hyperspectral camera system (TIVITA™) was tested for this purpose in an in vivo animal model. METHODS: Evaluation of tissue oxygenation during ischemia and upon reperfusion was performed in left hind limb in a rat model (n=20). Ischemia was induced by clamping and dissection of the superficial femoral artery...
October 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29080792/impact-of-shear-rate-pattern-on-post-occlusive-near-infrared-spectroscopy-microvascular-reactivity
#11
M Ramos Gonzalez, J T Caldwell, P A Branch, G C Wardlow, C D Black, J Campbell, R D Larson, C J Ade
The primary aim of the present study was to determine the impact of acute changes in shear rate patterns, in particular retrograde shear rate, on microvascular function in 15 healthy, young men and women as determined via the post-occlusive near-infrared spectroscopy (NIRS) microvascular reactivity response. Microvascular reactivity, via NIRS-derived measurements of post-occlusion tissue saturation index (TSI%) and total microvascular hemoglobin+myoglobin concentration ([Hb]total), were assessed in each participant before and immediately after exposure to a 30min retrograde shear treatment...
October 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29111303/in-vitro-characteristics-of-endothelial-cells-prepared-from-human-cerebral-arteriovenous-malformation-lesions-using-a-novel-method
#12
Q Hao, X L Chen, L Ma, X Ye, H Wang, T T Wang, Y Hu, Y L Zhao
BACKGROUND AND PURPOSE: The cerebral arteriovenous malformation (cAVM) is a usual and continually unaware reason of heamorrhage and seizure. It contains of feeder arteries, drain veins and abnormal vessel nets. However, pathologic mechanisms of the development of cAVM are unknown. The purpose of this study was to explore a novel protocol to isolate, culture and passage endothelial cells (ECs) from human cAVM lesions. METHODS: We developed a protocol for isolating and growing ECs from eight patients with cAVM...
October 28, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29069572/blood-flow-volume-and-arterio-venous-passages-in-induced-mammary-tumours-of-the-rat
#13
Ragnar Hultborn
OBJECTIVE: To study blood flow, vascular volume and arterio-venous passages in induced mammary tumours of the rat to characterize parameters possibly responsible for tumour hyponutrition. METHOD: Dimethylbenzanthracene-induced mammary tumours in Sprague-Dawley rats were studied. Regional blood flow was studied by use of the radioactive microsphere tracer technique using (141)Cerium-labelled 15μm spheres coinjected into the left cardiac ventricle with (125)Iodine-labelled 25μm spheres...
October 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28870649/lipopolysaccharide-impairs-permeability-of-pulmonary-microvascular-endothelial-cells-via-connexin40
#14
Hua-Song Zhou, Meng Li, Bing-Dong Sui, Lei Wei, Rui Hou, Wen-Sheng Chen, Qiang Li, Sheng-Hui Bi, Jin-Zhou Zhang, Ding-Hua Yi
The endotoxin lipopolysaccharide (LPS)-induced pulmonary endothelial barrier disruption is a key pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the molecular mechanisms underlying LPS-impaired permeability of pulmonary microvascular endothelial cells (PMVECs) are not fully understood. Gap junctions, particularly Connexin40 (Cx40), are necessary for the maintenance of normal vascular function. In this study, we for the first time investigated the role of Cx40 in LPS-impaired permeability of PMVECs and provided potential therapeutic approaches based on mechanistic findings of Cx40 regulation by LPS stimuli...
January 2018: Microvascular Research
https://www.readbyqxmd.com/read/28842183/pronounced-and-sustained-cutaneous-vasoconstriction-during-and-following-cyrotherapy-treatment-role-of-neurotransmitters-released-from-sympathetic-nerves
#15
Kevin M Christmas, Jordan C Patik, Sepideh Khoshnevis, Kenneth R Diller, R Matthew Brothers
Cryotherapy is a therapeutic technique using ice or cold water applied to the skin to manage soft tissue trauma and injury. While beneficial, there are some potentially detrimental side effects, such as pronounced vasoconstriction and tissue ischemia that are sustained for hours post-treatment. This study tested the hypothesis that this vasoconstriction is mediated by 1) activation of post-synaptic α-adrenergic receptors and/or 2) activation of post-synaptic neuropeptide Y1 (NPY Y1) receptors. 8 subjects were fitted with a commercially available cryotherapy unit with a water perfused bladder on the lateral portion of the right calf...
January 2018: Microvascular Research
https://www.readbyqxmd.com/read/28782513/the-effect-of-age-on-the-response-of-retinal-capillary-filling-to-changes-in-intraocular-pressure-measured-by-optical-coherence-tomography-angiography
#16
Xiaoyun Jiang, Elaine Johnson, William Cepurna, Diana Lozano, Shaojie Men, Ruikang K Wang, John Morrison
PURPOSE: To compare the effect of elevated intraocular pressure (IOP) on retinal capillary filling in elderly vs adult rats using optical coherence tomography angiography (OCTA). METHODS: The IOP of elderly (24-month-old, N=12) and adult (6-8month-old, N=10) Brown Norway rats was elevated in 10mmHg increments from 10 to 100mmHg. At each IOP level, 3D OCT data were captured using an optical microangiography (OMAG) scanning protocol and then post-processed to obtain both structural and vascular images...
January 2018: Microvascular Research
https://www.readbyqxmd.com/read/29051045/angiotensin-ii-regulates-%C3%AE-enac-in-human-umbilical-vein-endothelial-cells
#17
Charles A Downs, Nicholle M Johnson, Camila Coca, My N Helms
The amiloride-sensitive epithelial sodium channel (ENaC) has been characterized in a variety of non-epithelial tissues. In the current study we sought to understand the effect of angiotensin II on δ ENaC function using human umbilical vein endothelial cells (HUVECs). The δ ENaC subunit is found in humans, but notably absent in rat and most mouse epithelial tissues. In this study we report the presence of δ ENaC in HUVECS with a half-life of ~80min and a change in δ ENaC abundance when HUVECs were treated with angiotensin II...
October 16, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28993199/unraveling-the-role-of-hypoxia-inducible-factor-hif-1%C3%AE-and-hif-2%C3%AE-in-the-adaption-process-of-human-microvascular-endothelial-cells-hmec-1-to-hypoxia-redundant-hif-dependent-regulation-of-macrophage-migration-inhibitory-factor
#18
Martin Hahne, Peggy Schumann, Mathias Mursell, Cindy Strehl, Paula Hoff, Frank Buttgereit, Timo Gaber
Hypoxia driven angiogenesis is a prominent feature of tissue regeneration, inflammation and tumor growth and is regulated by hypoxia-inducible factor (HIF)-1 and -2. The distinct functions of HIFs in the hypoxia-induced angiogenesis and metabolic switch of endothelial cells are still unknown and therefore aim of this study. We investigated the role of HIF-1 and -2 in the adaptation of immortalized human microvascular endothelial cells (HMEC-1) to hypoxic conditions (1% O2) in terms of angiogenesis, cytokine secretion, gene expression and ATP/ADP-ratio using shRNA-mediated reduction of the oxygen sensitive α-subunits of either HIF-1 or HIF-2 or the combination of both...
October 6, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28954218/effects-of-insulin-analogs-as-an-add-on-to-metformin-on-cutaneous-microcirculation-in-type-2-diabetic-patients
#19
Marinos Fysekidis, Emmanuel Cosson, Karim Takbou, Angela Sutton, Nathalie Charnaux, Isabella Banu, Eric Vicaut, Paul Valensi
BACKGROUND: A single insulin injection was shown to improve microcirculatory blood flow. Our aim was to examine the effects of 4weeks of insulin therapy by three randomly assigned insulin analog regimens (Detemir, Aspart, and their combination) on cutaneous blood flow (CBF) and microcirculatory endothelial function as an add-on to metformin in type 2 diabetic patients poorly controlled on oral antidiabetic treatment. METHODS: Fourty-two type 2 diabetic patients with no history of cardiovascular disease in secondary failure to oral antidiabetic agents had CBF measurements before and after acetylcholine (Ach) iontophoretic administration...
September 24, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28943261/retinal-microcirculation-imaging-in-sickle-cell-disease-patients
#20
W Birkhoff, J de Vries, G Dent, A Verma, J L Kerkhoffs, A H F van Meurs, M de Kam, M Moerland, J Burggraaf
OBJECTIVES: To explore the feasibility of a new quantitative method for microvascular function: non-invasive retinal function imaging (RFI). in sickle cell disease (SCD) patients and healthy controls and have it benchmarked against Laser Speckle Contrast Imaging (LSCI) measurements. METHODS: The variability of Microvascular measurements was assessed in 8 SCD patients and 8 healthy matched controls. Measurements were conducted twice on two different study days. RFI was performed for assessment of arterial and venous retinal blood flow...
September 22, 2017: Microvascular Research
journal
journal
22012
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"