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Microvascular Research

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https://www.readbyqxmd.com/read/28077312/the-effect-of-calf-neuromuscular-electrical-stimulation-and-intermittent-pneumatic-compression-on-thigh-microcirculation
#1
Shayan Bahadori, Tikki Immins, Thomas W Wainwright
OBJECTIVE: This study compares the effectiveness of a neuromuscular electrical stimulation (NMES) device and an intermittent pneumatic compression (IPC) device on enhancing microcirculatory blood flow in the thigh of healthy individuals, when stimulation is carried out peripherally at the calf. MATERIALS AND METHODS: Blood microcirculation of ten healthy individuals was recorded using laser speckle contrast imaging (LSCI) technique.A region of interest (ROI) was marked on each participant thigh...
January 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28065673/spectral-analysis-of-reflex-cutaneous-vasodilatation-during-passive-heat-stress
#2
Matthew M Mallette, Gary J Hodges, Gregory W McGarr, David A Gabriel, Stephen S Cheung
Previous work has demonstrated that spectral analysis is a useful tool to non-invasively ascertain the mechanisms of control of the cutaneous circulation. The majority of work using spectral analysis has focused on local control mechanisms, with none examining reflex control. Skin blood flow was analysed using spectral analysis on the dorsal aspect of the forearm of 7 males and 7 females during passive heat stress, with mean forearm and local temperature at the site of measurement maintained at thermoneutral (33°C) to minimize the effect of local control mechanisms...
January 5, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28065672/monitoring-microvascular-perfusion-variations-with-laser-speckle-contrast-imaging-using-a-view-based-temporal-template-method
#3
Mohammad Zaheer Ansari, Eun-Jeung Kang, Mioara D Manole, Jens P Dreier, Anne Humeau-Heurtier
PURPOSE: Laser speckle contrast imaging (LSCI) continues to gain an increased interest in clinical and research studies to monitor microvascular perfusion. Due to its high spatial and temporal resolutions, LSCI may lead to a large amount of data. The analysis of such data, as well as the determination of the regions where the perfusion varies, can become a lengthy and tedious task. We propose here to analyze if a view-based temporal template method, the motion history image (MHI) algorithm, may be of use in detecting the perfusion variations locations...
January 5, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28040437/cryptotanshinone-inhibits-vegf-induced-angiogenesis-by-targeting-the-vegfr2-signaling-pathway
#4
Xiaoming Xu, Li Wu, Xinbin Zhou, Nanyang Zhou, Qin Zhuang, Jinxiu Yang, Jin Dai, Haibing Wang, Shenjie Chen, Wei Mao
OBJECTIVE: Anti-angiogenesis has been proposed as an important strategy for angiogenesis-related diseases. Cryptotanshinone (CPT), an active component of Salvia miltiorrhiza, may be a potential inhibitor of angiogenesis. However, the molecular mechanisms underlying its anti-angiogenic activities remain poorly understood. This study is to investigate the effects of CPT on VEGF-induced angiogenesis and VEGFR2 signaling pathway in human umbilical vein endothelial cells (HUVECs). METHODS: HUVECs were treated with different concentration of CPT (5-20μmol/L) and the viability, endothelial cell migration, invasion, and tubular-like structure formation of HUVECs were detected by MTT, wound-healing migration, Transwell invasion and Matrigel tube formation assays, respectively...
December 28, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28027937/reduced-perfusion-in-systemic-sclerosis-digital-ulcers-both-fingertip-and-extensor-can-be-increased-by-topical-application-of-glyceryl-trinitrate
#5
M Hughes, T Moore, J Manning, J Wilkinson, G Dinsdale, C Roberts, A Murray, A L Herrick
OBJECTIVES: In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma. Our aim was to assess blood flow response to topical glyceryl trinitrate (GTN) compared to placebo in SSc DUs, looking for differences in pathophysiology between fingertip and extensor lesions. METHOD: This was a double-blind, randomised, crossover, placebo-controlled study. Sixteen (6 fingertip, 10 extensor) DUs were each studied twice (one day apart): once with GTN and once with placebo ointment...
December 24, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28025064/effects-of-nuclear-factor-e2-related-factor-2-heme-oxygenase-1-on-splanchnic-hemodynamics-in-experimental-cirrhosis-with-portal-hypertension
#6
Jun Qin, Yue He, Ming Duan, Meng Luo
OBJECTIVE: We explored the effects of Nuclear Factor-E2-related factor 2 (Nrf2) and Heme Oxygenase 1 (HO-1) on splanchnic hemodynamics in portal hypertensive rats. METHODS: Experimental cirrhosis with portal hypertension was induced by intraperitoneal injection of carbon tetrachloride. The expression of proteins was examined by immunoblotting. Hemodynamic studies were performed by radioactive microspheres. The vascular perfusion system was used to measure the contractile response of mesentery arterioles in rats...
December 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28012884/erythrocytes-properties-in-varicose-veins-patients
#7
L Gwozdzinski, A Pieniazek, J Bernasinska, M Grabowski, E Kowalczyk, K Gwozdzinski
Varicose veins (VV) are enlarged veins of the subcutaneous tissue, usually caused by faulty or damaged venous valves leading to impaired blood flow. Blood stasis, excessive clotting disorder and alterations in the vein walls are symptoms of Virchow's triad which may affect the morphotic elements of blood, including erythrocytes. The aim of this study was to investigate alterations in the properties of the erythrocytes taken from varicose veins in comparison to those from antecubital vein of patients with chronic venous disease...
December 21, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28011052/characterizing-human-skin-blood-flow-regulation-in-response-to-different-local-skin-temperature-perturbations
#8
Y Wu, M D Nieuwenhoff, F J P M Huygen, F C T van der Helm, S Niehof, A C Schouten
Small nerve fibers regulate local skin blood flow in response to local thermal perturbations. Small nerve fiber function is difficult to assess with classical neurophysiological tests. In this study, a vasomotor response model in combination with a heating protocol was developed to quantitatively characterize the control mechanism of small nerve fibers in regulating skin blood flow in response to local thermal perturbation. The skin of healthy subjects' hand dorsum (n=8) was heated to 42°C with an infrared lamp, and then naturally cooled down...
December 20, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27998712/impacts-of-femoral-artery-and-vein-excision-versus-femoral-artery-excision-on-the-hindlimb-ischemic-model-in-cd-1-mice
#9
Miao Chen, Huimin Fan, Benjamin T Ledford, Zayd Farah, Catherine Barron, Zhongmin Liu, Jia-Qiang He
BACKGROUND AND AIM: Although femoral artery ligation-induced ischemia is commonly used in C57BL/6 or Balb/c mice, direct comparisons between femoral artery/vein (FAV) versus femoral artery (FA) excisions have not been reported. The goal of the present study is to investigate the effects of FAV versus FA excisions on hindlimb models using adult CD-1 mice. METHODS: Two groups (n=10/group) of adult, mixed gender CD-1 mice were used to generate hindlimb ischemic models by excising either the FAV or FA...
December 18, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27989404/nailfold-capillaroscopic-parameters-and-skin-telangiectasia-patterns-in-patients-with-systemic-sclerosis
#10
Carmen Pizzorni, Anna R Giampetruzzi, Chiara Mondino, Antonio Facchiano, Damiano Abeni, Sabrina Paolino, Barbara Ruaro, Vanessa Smith, Alberto Sulli, Maurizio Cutolo
OBJECTIVE: To correlate nailfold capillaroscopic parameters with the presence of skin telangiectases (TAs) in systemic sclerosis patients (SSc). METHODS: Thirty-three consecutive patients (28 women and 5 men, mean age 59±21years) affected by SSc according to the ACR/EULAR criteria, 30 with limited (lcSSc) and 3 with diffuse (dcSSc) skin disease, displaying the presence of skin TAs on face, hands, forearms, neck, and décolleté were recruited. Nailfold videocapillaroscopy (NVC) was performed to classify the patients into one of the three main patterns of SSc microangiopathy ("early", "active", "late"), and to calculate the microangiopathy evolution score (MES)...
December 16, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27988246/identification-of-neuronal-and-angiogenic-growth-factors-in-an-in-vitro-blood-brain-barrier-model-system-relevance-in-barrier-integrity-and-tight-junction-formation-and-complexity
#11
Christian Freese, Sanshiro Hanada, Petra Fallier-Becker, C James Kirkpatrick, Ronald E Unger
We previously demonstrated that the co-cultivation of endothelial cells with neural cells resulted in an improved integrity of the in vitro blood-brain barrier (BBB), and that this model could be useful to evaluate the transport properties of potential central nervous system disease drugs through the microvascular brain endothelial. In this study we have used real-time PCR, fluorescent microscopy, protein arrays and enzyme-linked immunosorbent assays to determine which neural- and endothelial cell-derived factors are produced in the co-culture and improve the integrity of the BBB...
December 15, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27956355/expression-and-production-of-cardiac-angiogenic-mediators-depend-on-the-trypanosoma-cruzi-genetic-population-in-experimental-c57bl-6-mice-infection
#12
Deena Shrestha, Bijay Bajracharya, Guilherme Paula-Costa, Beatriz C Salles, Ana Luísa J Leite, Ana Paula J Menezes, Débora Ms Souza, Laser Am Oliveira, André Talvani
Mammalian cardiac cells are important targets to the protozoan Trypanosoma cruzi. The inflammatory reaction in the host aims at eliminating this parasite, can lead to cell destruction, fibrosis and hypoxia. Local hypoxia is well-defined stimulus to the production of angiogenesis mediators. Assuming that different genetic T. cruzi populations induce distinct inflammation and disease patterns, the current study aims to investigate whether the production of inflammatory and angiogenic mediators is a parasite strain-dependent condition...
December 9, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27908703/simultaneous-effects-of-coagulation-and-variable-magnetic-field-on-peristaltically-induced-motion-of-jeffrey-nanofluid-containing-gyrotactic-microorganism
#13
M M Bhatti, A Zeeshan, R Ellahi
In this article, simultaneous effects of coagulation (blood clot) and variable magnetic field on peristaltically induced motion of non-Newtonian Jeffrey nanofluid containing gyrotactic microorganism through an annulus have been studied. The effects of an endoscope also taken into consideration in our study as a special case. The governing flow problem is simplified by taking the approximation of long wavelength and creeping flow regime. The resulting highly coupled differential equations are solved analytically with the help of perturbation method and series solution have been presented up to second order approximation...
November 29, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27902934/the-vascular-evolution-of-an-extended-flap-on-the-dorsum-of-rats-and-the-potential-involvement-of-mmp-2-and-mmp-9
#14
Yuehong Zhuang, Fang Fang, Xue Lan, Feng Wang, Junying Huang, Qi Zhang, Li Zhao, Wei Guo, Heping Zheng, Jianwen Xu
No abstract text is available yet for this article.
November 27, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27899298/mechanisms-and-time-course-of-menthol-induced-cutaneous-vasodilation
#15
Daniel H Craighead, Nathaniel B McCartney, James H Tumlinson, Lacy M Alexander
Menthol is a vasoactive compound that is widely used in topical analgesic agents. Menthol induces cutaneous vasodilation, however the underlying mechanisms are unknown. Determining the rates of appearance and clearance of menthol in the skin is important for optimizing topical treatment formulation and dosing. The purpose of this study was to determine the mechanisms contributing to menthol-mediated cutaneous vasodilation and to establish a time course for menthol appearance/clearance in the skin. Ten young (23±1years, 5 males 5 females) subjects participated in two protocols...
November 27, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27894918/laser-speckle-contrast-imaging-and-oxygen-to-see-for-assessing-microcirculatory-liver-blood-flow-changes-following-different-volumes-of-hepatectomy
#16
Chong Hui Li, Xin Lan Ge, Ke Pan, Peng Fei Wang, Yi Nan Su, Ai Qun Zhang
OBJECTIVE: Portal hyperperfusion after extended hepatectomy or small-for-size liver transplantation may induce organ dysfunction and failure. This study was designed to monitor and characterize the hepatic microcirculatory perfusion following different volumes of hepatectomy in rats by using laser speckle contrast image (LSCI) and Oxygen to See (O2C), a spectrometric device. METHODS: The microcirculatory liver blood flow of the rats that underwent 68%, 85% and 90% hepatectomy (68PH, 85PH and 90PH) was monitored with LSCI and O2C before and following the hepatectomy...
November 25, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27889559/plasma-endothelial-microparticles-reflect-the-extent-of-capillaroscopic-alterations-and-correlate-with-the-severity-of-skin-involvement-in-systemic-sclerosis
#17
Małgorzata Michalska-Jakubus, Otylia Kowal-Bielecka, Vanessa Smith, Maurizio Cutolo, Dorota Krasowska
INTRODUCTION AND AIM: Endothelial microparticles (EMPs) are membrane-coated vesicles shed from endothelial cells and are considered markers of the endothelial state. It has been shown that total numbers of circulating EMPs are increased in patients with systemic sclerosis (SSc), but their clinical correlations have not yet been investigated in detail. We aimed to assess possible relationships between circulating EMPs and clinical as well as laboratory features among SSc patients with special attention to possible association with alteration in microvascular morphology objectified on nailfold videocapillaroscopy and clinical signs of microvascular complications...
November 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27889558/the-periosteal-microcirculation-in-health-and-disease-an-update-on-clinical-significance
#18
REVIEW
Andrea Szabó, Ágnes Janovszky, Levente Pócs, Mihály Boros
Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma-orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism...
November 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27838313/in-systemic-sclerosis-skin-perfusion-of-hands-is-reduced-and-may-predict-the-occurrence-of-new-digital-ulcers
#19
Biagio Barbano, Alessandro Maria Marra, Silvia Quarta, Antonietta Gigante, Giuseppe Barilaro, Maria Ludovica Gasperini, Edoardo Rosato
Systemic sclerosis (SSc) patients are at high risk for the development of ischemic digital ulcers (DUs). The aim of this study was to assess in SSc patients a correlation between skin perfusion evaluated by LDPI and DUs and to evaluate the prognostic value of skin perfusion to predict the new DUs occurrence. Fifty eight (47 female, 11 male) SSc patients were enrolled. Skin perfusion of hands and region of interest (ROIs) was measured by Laser Doppler perfusion Imager (LDPI). The proximal-distal gradient (PDG) was present when the perfusion mean difference between ROI1 and ROI2 was >30 pU...
November 9, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28086994/retraction-notice-to-calponin-and-caldesmon-cellular-domains-in-reacting-microvessels-following-traumatic-brain-injury-microvasc-res-71-2006-7
#20
Christian W Kreipke, Noah C Morgan, Theodor Petrov, Jose A Rafols
No abstract text is available yet for this article.
March 2017: Microvascular Research
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