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Microvascular Research

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https://www.readbyqxmd.com/read/29981761/evidence-of-macro-and-micro-angiopathy-in-scleroderma-an-integrated-approach-combining-22-mhz-power-doppler-ultrasonography-and-video-capillaroscopy
#1
Schioppo Tommaso, Orenti Annalisa, Boracchi Patrizia, De Lucia Orazio, Murgo Antonella, Ingegnoli Francesca
OBJECTIVE: We aimed to study in SSc patients macrovascular involvement by using power Doppler ultrasound (PDUS) and microvascular one by PDUS and nailfold video-capillaroscopy (NVC) and to examine the association between history of digital ulcers (HDU) and imaging (PDUS and NVC) parameters. METHODS: NVC and PDUS were systematically performed in 106 consecutive SSc patients at the 3rd and 4th finger of the dominant hand after exclusion of ulnar artery occlusion (UAO)...
July 5, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29991448/the-effects-of-hydrogen-sulfide-on-microvascular-circulation-in-the-axial-pattern-flap-ear-model-in-hairless-mice
#2
Eberhard Grambow, Vicky A Augustin, Daniel Strüder, Günther Kundt, Ernst Klar, Brigitte Vollmar
No abstract text is available yet for this article.
July 2, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29991447/resting-cerebral-blood-flow-alterations-specific-to-the-comitant-exophoria-patients-revealed-by-arterial-spin-labeling-perfusion-magnetic-resonance-imaging
#3
Xin Huang, Sheng Zhou, Ting Su, Lei Ye, Pei-Wen Zhu, Wen-Qing Shi, You-Lan Min, Qing Yuan, Qi-Chen Yang, Fu-Qing Zhou, Yi Shao
PURPOSE: It has been shown in many previous studies that there were significant changes of the brain anatomy and function in strabismus. However, the significance of the alterations of resting cerebral blood flow (CBF) in comitant exophoria (CE) remains obscure. Arterial spin labeling (ASL) MRI, which is a noninvasive method, could be applied to detect the cerebral blood flow quantitatively. Our study aimed to compare the resting CBF between the comitant exophoria and health controls using pseudo-continuous arterial spin labeling (pCASL) perfusion MRI method...
July 2, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29958863/image-enhancement-effect-on-inter-and-intra-observer-reliability-of-nailfold-capillary-assessment
#4
Abdolamir Karbalaie, Mahnaz Etehadtavakol, Farhad Abtahi, Alimohammad Fatemi, Zahra Emrani, Björn-Erik Erlandsson
BACKGROUND: Nailfold capillaroscopy (NC) is a diagnostic imaging technique that is used to assess the blood capillary network in the nailfold area. NC is routinely used for patients with microcirculation problems, such as systemic sclerosis and other connective tissue diseases. Experts commonly use subjective evaluation as a reference point in images of nailfold video capillaroscopy, so it is important to reduce the inherent ambiguities in human judgment and diagnosis. Image quality is an important factor that affects measurement error and assessment time of NC images...
June 27, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29958862/microvascular-endothelial-dysfunction-during-cardiopulmonary-bypass-in-surgery-for-correction-of-cyanotic-and-acyanotic-congenital-heart-disease
#5
Viviana Ugenti, Ana Catarina Romano, Eduardo Tibiriçá
OBJECTIVE: To evaluate endothelium-dependent microvascular reactivity during cardiopulmonary bypass (CPB) in surgery for the correction of cyanotic and acyanotic congenital heart disease (CHD) in children and infants using laser Doppler perfusion monitoring (LDPM). METHODS: This cross-sectional observational study included one hundred consecutive acyanotic (AC, n = 61) and cyanotic (C, n = 39) pediatric patients scheduled for cardiac surgery for correction of CHD...
June 26, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29940198/exercise-preconditioning-and-low-dose-copper-nanoparticles-exhibits-cardioprotection-through-targeting-gsk-3%C3%AE-phosphorylation-in-ischemia-reperfusion-induced-myocardial-infarction
#6
Arun K Sharma, Ashish Kumar, Megha Sahu, Gunjan Sharma, Ashok K Datusalia, Satyendra K Rajput
BACKGROUND: Drinking water from copper vessels and aerobic exercise have been the known facts for cardioprotection. Our previous report explored the significant cardioprotective potential of copper and exercise training by increasing phosphorylation of GSK-3β and anti-oxidant potential. OBJECTIVE: Present study focuses the therapeutic potential of CuNP and exercise training through their molecular interaction with GSK-3β, inflammatory cytokinin, oxidative stress and necrosis...
June 22, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29902475/quantitative-protein-profiling-and-pathway-analysis-of-spinal-arteriovenous-malformations
#7
Yi Guo, Benhong Xu, Zhenxing Sun, Youtu Wu, Wei Shi, Jin Wang, Xianbin Meng, Wei Ge, Guihuai Wang
Spinal arteriovenous malformations (sAVM) are rare and heterogeneous group of blood vessel disorders that affect spinal cord function directly or indirectly; however, the pathogenesis of sAVM is still unclear. In this study, we compared four sAVM specimens obtained during surgery and donated control samples in a Tandem Mass Tag (TMT)-labeled proteomic analysis. We identified 3101 proteins, 654 of which were differentially expressed in sAVM samples compared with the controls. Of these, 96 proteins were upregulated and 358 proteins were downregulated...
June 12, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29883621/association-of-cardiorespiratory-fitness-with-retinal-vessel-diameters-as-a-biomarker-of-cardiovascular-risk
#8
Gioia Braun, Benjamin Hafner, Karsten Königstein, Denis Infanger, Christopher Klenk, Anja Rossmeissl, Arno Schmidt-Trucksäss, Henner Hanssen
OBJECTIVE: We aimed to investigate the association of retinal microvascular health with cardiorespiratory fitness (VO2 peak) and cardiovascular risk factors. METHODS: In a population of 260 obesity-enriched participants we investigated the association of retinal vessel diameters with cardiorespiratory fitness (CRF), body mass index (BMI) and blood pressure (BP). Retinal vessel imaging was performed by use of a fundus camera and a semi-automated processing software, calculating the central retinal arteriolar (CRAE) and venular equivalent (CRVE) as well as the arteriolar-to-venular diameter ratio (AVR)...
June 5, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29870781/l-citrulline-restores-nitric-oxide-level-and-cellular-uptake-at-the-brain-capillary-endothelial-cell-line-tr-bbb-cells-with-glutamate-cytotoxicity
#9
Kyeong-Eun Lee, Young-Sook Kang
OBJECTIVE: Glutamate excitotoxicity provokes neuronal cell damage and death, leading to collapse of the blood-brain barrier (BBB). Recently, it has been reported that l-citrulline, a neutral amino acid and a major precursor of l-arginine in the nitric oxide (NO) cycle, can prevent both neuronal cell death and cerebrovascular cell loss in brain ischemia. Therefore, the objective of this study was to investigate the effect of l-citrulline on glutamate cytotoxicity in the BBB using the conditionally immortalized rat brain capillary endothelial cell line (TR-BBB cells) as an in vitro model of the BBB...
June 2, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29859746/impact-of-lipid-modulation-on-the-intestinal-microcirculation-in-experimental-sepsis
#10
Annette Wegner, Dragan Pavlovic, Sebastian Haußmann-Vopel, Christian Lehmann
It has been observed, that patients who were treated medically for dyslipoproteinemia had a potentially lower risk of complications during infection and sepsis, regarding both morbidity and mortality. Aim of this study in experimental sepsis was to elucidate the impact of lipid metabolism modulation by simvastatin, HDL, or bezafibrate, respectively, on the intestinal microcirculation which plays a crucial role in the development of multiple organ failure in sepsis. Experimental sepsis was induced in Lewis rats by intravenous lipopolysaccharide (LPS) administration...
June 1, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29803580/sublethal-mechanical-trauma-alters-the-electrochemical-properties-and-increases-aggregation-of-erythrocytes
#11
Antony P McNamee, Geoff D Tansley, Michael J Simmonds
Circulation of blood depends, in part, on the ability of red blood cells (RBCs) to aggregate, disaggregate, and deform. The primary intrinsic disaggregating force of RBCs is derived from their electronegativity, which is largely determined by sialylated glycoproteins on the plasma membrane. Given supraphysiological shear exposure - even at levels below those which induce hemolysis - alters cell morphology, we hypothesized that exposure to supraphysiological and subhemolytic shear would cleave membrane-bound sialic acid, altering the electrochemical and physical properties of RBCs, and thus increase RBC aggregation...
May 24, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29802880/spectral-analysis-of-the-blood-flow-in-the-foot-microvascular-bed-during-thermal-testing-in-patients-with-diabetes-mellitus
#12
Irina Mizeva, Elena Zharkikh, Viktor Dremin, Evgeny Zherebtsov, Irina Makovik, Elena Potapova, Andrey Dunaev
Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In this study Laser Doppler flowmetry, a noninvasive technique for the cutaneous blood flow monitoring, was utilized together with local temperature tests and wavelet analysis. The study of the blood flow in the microvascular bed of toes was carried out in the control group of 40 healthy subjects and in two groups of 17 type 1 and 23 type 2 diabetic patients...
May 23, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29777793/homocysteine-induces-vascular-inflammatory-response-via-smad7-hypermethylation-in-human-umbilical-vein-smooth-muscle-cells
#13
Li-Hua Wei, Nai-Xia Chao, Si Gao, Ya-Ting Yu, Lin Shi, Xin-Bo Ma, Na Liao, Ke Lan, Yu Luo, Zheng-Yi Xie, Yuan-Yuan Li
Homocysteine (Hcy) can induce atherosclerosis through the inflammatory response and DNA methylation disorder. Our recent study has reported a novel epigenetic modified gene related to atherosclerosis -SMAD7. To further understand the pathogenesis of atherosclerosis, the current study was designed to investigate an inflammatory role of Hcy in human umbilical vein smooth muscle cells (HUVSMCs) through interfering with SMAD7 methylation. Using MALDI-TOF MS, we found that Hcy increased DNA methylation levels of SMAD7 promoter in a dose and time-dependent manner in HUVSMCs...
May 17, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29777792/human-cancer-cells-suppress-behaviors-of-endothelial-progenitor-cells-through-mir-21-targeting-il6r
#14
Wenbin Wang, Xiao Yuan, Aman Xu, Xingyang Zhu, Yanqing Zhan, Shuanhu Wang, Mulin Liu
Deep vein thrombosis (DVT) is a severe clinical process and has a high rate of fatality. Cancer patients have a high incidence rate of venous thrombosis complication and increase the mortality of cancer patients for 2-8 times. The mechanisms involved in human cancers and venous thrombosis remains unclear. In this study, we determined miR-21 expressed higher in human breast cancer, colon cancer and hepatocellular cancer tissues compared with normal tissues and expressed higher in exosomes of breast cancer and hepatocellular cancer cell lines compared with normal cells...
May 17, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29778648/impact-of-insulin-on-the-intestinal-microcirculation-in-a-model-of-sepsis-related-hyperglycemia
#15
Alexa Caldwell, Jan Niklas Morick, Anne-Marie Jentsch, Annette Wegner, Dragan Pavlovic, Nadia Al-Banna, Christian Lehmann
BACKGROUND: Sepsis involves dysfunctional glucose metabolism. Among patients with sepsis, hyperglycemia is frequent and insulin administration has been evaluated for glycemic control to improve patient outcomes. Only few studies have examined the hyperglycemic microcirculation and the impact of insulin on the microvasculature in sepsis. OBJECTIVE: To study the functional capillary density (FCD) and leukocyte activation within the intestinal microcirculation in endotoxin-induced experimental sepsis...
September 2018: Microvascular Research
https://www.readbyqxmd.com/read/29777791/ticagrelor-protects-against-angii-induced-endothelial-dysfunction-by-alleviating-endoplasmic-reticulum-stress
#16
Xiaoyu Wang, Xuejie Han, Minghui Li, Yu Han, Yun Zhang, Shiqi Zhao, Yue Li
Ticagrelor has been reported to decrease cardiovascular mortality compared with clopidogrel. This benefit cannot be fully explained by the more efficient platelet inhibition. Many studies demonstrated that ticagrelor improved endothelial function, leaving the mechanism elusive though. The present study aims to investigate whether ticagrelor protects against endothelial dysfunction induced by angiotensinII (AngII) through alleviating endoplasmic reticulum (ER) stress. Male Sprague Dawley rats were infused with AngII or vehicle and administrated with ticagrelor or vehicle for 14 days...
September 2018: Microvascular Research
https://www.readbyqxmd.com/read/29742454/the-pivotal-role-of-angiogenesis-in-a-multi-scale-modeling-of-tumor-growth-exhibiting-the-avascular-and-vascular-phases
#17
Hooman Salavati, M Soltani, Saeid Amanpour
The mechanisms involved in tumor growth mainly occur at the microenvironment, where the interactions between the intracellular, intercellular and extracellular scales mediate the dynamics of tumor. In this work, we present a multi-scale model of solid tumor dynamics to simulate the avascular and vascular growth as well as tumor-induced angiogenesis. The extracellular and intercellular scales are modeled using partial differential equations and cellular Potts model, respectively. Also, few biochemical and biophysical rules control the dynamics of intracellular level...
September 2018: Microvascular Research
https://www.readbyqxmd.com/read/29742453/effect-of-p-tyrosol-on-hemorheological-parameters-and-cerebral-capillary-network-in-young-spontaneously-hypertensive-rats
#18
Mark B Plotnikov, Oleg I Aliev, Anastasia V Sidekhmenova, Alexander Y Shamanaev, Anna M Anishchenko, Tatiana I Fomina, Tatiana M Plotnikova, Alexander M Arkhipov
BACKGROUND: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms. OBJECTIVE: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied. METHODS: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i...
September 2018: Microvascular Research
https://www.readbyqxmd.com/read/29738719/the-role-of-rho-kinase-and-calcium-ions-in-constriction-triggered-by-et-1
#19
Michał Wiciński, Katarzyna Szadujkis-Szadurska, Mateusz M Węclewicz, Bartosz Malinowski, Grzegorz Matusiak, Maciej Walczak, Eryk Wódkiewicz, Grzegorz Grześk, Katarzyna Pawlak-Osińska
Endothelin-1 (ET-1) is one of the key factors regulating tension of smooth muscles in blood vessels. It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress. The main objective of this paper was to evaluate the role of Rho-kinase in the ET-1-induced constriction of arteries. The analysis also included significance of intra- and extracellular pool of calcium ions in constriction triggered by ET-1...
September 2018: Microvascular Research
https://www.readbyqxmd.com/read/29705580/impaired-function-of-cerebral-parenchymal-arterioles-in-experimental-preeclampsia
#20
Abbie C Johnson, Marilyn J Cipolla
Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supplying frontoparietal white matter (WM) tracts and cortex and compared to normal pregnant (Preg) and nonpregnant (Nonpreg) Sprague Dawley rats (n = 8/group)...
September 2018: Microvascular Research
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