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Microvascular Research

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https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#1
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
November 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29107094/hyperspectral-imaging-for-monitoring-of-perfusion-failure-upon-microvascular-anastomosis-in-the-rat-hind-limb
#2
Eberhard Grambow, Michael Dau, Amadeus Holmer, Vicky Lipp, Bernhard Frerich, Ernst Klar, Brigitte Vollmar, Peer Wolfgang Kämmerer
BACKGROUND/PURPOSE: Objective, reliable and easy monitoring of microvascular tissue perfusion is a goal that was achieved for many years with limited success. Therefore, a new non-invasive hyperspectral camera system (TIVITA™) was tested for this purpose in an in vivo animal model. METHODS: Evaluation of tissue oxygenation during ischemia and upon reperfusion was performed in left hind limb in a rat model (n=20). Ischemia was induced by clamping and dissection of the superficial femoral artery...
October 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29080792/impact-of-shear-rate-pattern-on-post-occlusive-near-infrared-spectroscopy-microvascular-reactivity
#3
M Ramos Gonzalez, J T Caldwell, P A Branch, G C Wardlow, C D Black, J Campbell, R D Larson, C J Ade
The primary aim of the present study was to determine the impact of acute changes in shear rate patterns, in particular retrograde shear rate, on microvascular function in 15 healthy, young men and women as determined via the post-occlusive near-infrared spectroscopy (NIRS) microvascular reactivity response. Microvascular reactivity, via NIRS-derived measurements of post-occlusion tissue saturation index (TSI%) and total microvascular hemoglobin+myoglobin concentration ([Hb]total), were assessed in each participant before and immediately after exposure to a 30min retrograde shear treatment...
October 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29111303/in-vitro-characteristics-of-endothelial-cells-prepared-from-human-cerebral-arteriovenous-malformation-lesions-using-a-novel-method
#4
Q Hao, X L Chen, L Ma, X Ye, H Wang, T T Wang, Y Hu, Y L Zhao
BACKGROUND AND PURPOSE: The cerebral arteriovenous malformation (cAVM) is a usual and continually unaware reason of heamorrhage and seizure. It contains of feeder arteries, drain veins and abnormal vessel nets. However, pathologic mechanisms of the development of cAVM are unknown. The purpose of this study was to explore a novel protocol to isolate, culture and passage endothelial cells (ECs) from human cAVM lesions. METHODS: We developed a protocol for isolating and growing ECs from eight patients with cAVM...
October 28, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29069572/blood-flow-volume-and-arterio-venous-passages-in-induced-mammary-tumours-of-the-rat
#5
Ragnar Hultborn
OBJECTIVE: To study blood flow, vascular volume and arterio-venous passages in induced mammary tumours of the rat to characterize parameters possibly responsible for tumour hyponutrition. METHOD: Dimethylbenzanthracene-induced mammary tumours in Sprague-Dawley rats were studied. Regional blood flow was studied by use of the radioactive microsphere tracer technique using (141)Cerium-labelled 15μm spheres coinjected into the left cardiac ventricle with (125)Iodine-labelled 25μm spheres...
October 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29051045/angiotensin-ii-regulates-%C3%AE-enac-in-human-umbilical-vein-endothelial-cells
#6
Charles A Downs, Nicholle M Johnson, Camila Coca, My N Helms
The amiloride-sensitive epithelial sodium channel (ENaC) has been characterized in a variety of non-epithelial tissues. In the current study we sought to understand the effect of angiotensin II on δ ENaC function using human umbilical vein endothelial cells (HUVECs). The δ ENaC subunit is found in humans, but notably absent in rat and most mouse epithelial tissues. In this study we report the presence of δ ENaC in HUVECS with a half-life of ~80min and a change in δ ENaC abundance when HUVECs were treated with angiotensin II...
October 16, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28993199/unraveling-the-role-of-hypoxia-inducible-factor-hif-1%C3%AE-and-hif-2%C3%AE-in-the-adaption-process-of-human-microvascular-endothelial-cells-hmec-1-to-hypoxia-redundant-hif-dependent-regulation-of-macrophage-migration-inhibitory-factor
#7
Martin Hahne, Peggy Schumann, Mathias Mursell, Cindy Strehl, Paula Hoff, Frank Buttgereit, Timo Gaber
Hypoxia driven angiogenesis is a prominent feature of tissue regeneration, inflammation and tumor growth and is regulated by hypoxia-inducible factor (HIF)-1 and -2. The distinct functions of HIFs in the hypoxia-induced angiogenesis and metabolic switch of endothelial cells are still unknown and therefore aim of this study. We investigated the role of HIF-1 and -2 in the adaptation of immortalized human microvascular endothelial cells (HMEC-1) to hypoxic conditions (1% O2) in terms of angiogenesis, cytokine secretion, gene expression and ATP/ADP-ratio using shRNA-mediated reduction of the oxygen sensitive α-subunits of either HIF-1 or HIF-2 or the combination of both...
October 6, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28954218/effects-of-insulin-analogs-as-an-add-on-to-metformin-on-cutaneous-microcirculation-in-type-2-diabetic-patients
#8
Marinos Fysekidis, Emmanuel Cosson, Karim Takbou, Angela Sutton, Nathalie Charnaux, Isabella Banu, Eric Vicaut, Paul Valensi
BACKGROUND: A single insulin injection was shown to improve microcirculatory blood flow. Our aim was to examine the effects of 4weeks of insulin therapy by three randomly assigned insulin analog regimens (Detemir, Aspart, and their combination) on cutaneous blood flow (CBF) and microcirculatory endothelial function as an add-on to metformin in type 2 diabetic patients poorly controlled on oral antidiabetic treatment. METHODS: Fourty-two type 2 diabetic patients with no history of cardiovascular disease in secondary failure to oral antidiabetic agents had CBF measurements before and after acetylcholine (Ach) iontophoretic administration...
September 24, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28943261/retinal-microcirculation-imaging-in-sickle-cell-disease-patients
#9
W Birkhoff, J de Vries, G Dent, A Verma, J L Kerkhoffs, A H F van Meurs, M de Kam, M Moerland, J Burggraaf
OBJECTIVES: To explore the feasibility of a new quantitative method for microvascular function: non-invasive retinal function imaging (RFI). in sickle cell disease (SCD) patients and healthy controls and have it benchmarked against Laser Speckle Contrast Imaging (LSCI) measurements. METHODS: The variability of Microvascular measurements was assessed in 8 SCD patients and 8 healthy matched controls. Measurements were conducted twice on two different study days. RFI was performed for assessment of arterial and venous retinal blood flow...
September 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28918110/emergent-behaviors-in-rbcs-flows-in-micro-channels-using-digital-particle-image-velocimetry
#10
F Cairone, D Ortiz, P J Cabrales, M Intaglietta, M Bucolo
The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, however their introduction, also, for pathological conditions diagnosis would be important in different biomedical contexts. To overcome this lack is necessary to establish the relation between the RBCs flow and blood viscosity changes in micro-vessels...
September 13, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28888910/the-influence-of-adherent-cell-morphology-on-hydrodynamic-recruitment-of-leukocytes
#11
Dhananjay Radhakrishnan Subramaniam, David J Gee
Innate immunity is characterized by the coordinated activity of multiple leukocytes mobilizing at or near the site of tissue injury. Slow rolling and/or adherent leukocytes have been shown to hydrodynamically recruit free-stream leukocytes to a model of inflamed tissue. In this paper, we numerically investigate the hydrodynamic recruitment of free-stream leukocytes due to the presence of a nearby adherent, deformed leukocyte by using a computational model developed from first principles to simulate these types of interactions...
September 6, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28870649/lipopolysaccharide-impairs-permeability-of-pulmonary-microvascular-endothelial-cells-via-connexin40
#12
Hua-Song Zhou, Meng Li, Bing-Dong Sui, Lei Wei, Rui Hou, Wen-Sheng Chen, Qiang Li, Sheng-Hui Bi, Jin-Zhou Zhang, Ding-Hua Yi
The endotoxin lipopolysaccharide (LPS)-induced pulmonary endothelial barrier disruption is a key pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the molecular mechanisms underlying LPS-impaired permeability of pulmonary microvascular endothelial cells (PMVECs) are not fully understood. Gap junctions, particularly Connexin40 (Cx40), are necessary for the maintenance of normal vascular function. In this study, we for the first time investigated the role of Cx40 in LPS-impaired permeability of PMVECs and provided potential therapeutic approaches based on mechanistic findings of Cx40 regulation by LPS stimuli...
September 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28859929/cutaneous-and-renal-vasodilatory-response-to-local-pressure-application-a-comparative-study-in-mice
#13
Anne-Laure Begey, Kiao Ling Liu, Ming Lo, Audrey Josset-Lamaugarny, Nicolas Picard, Catherine Gauthier, Berengere Fromy, Dominique Sigaudo-Roussel, Laurence Dubourg
BACKGROUND AND AIM: We have reported a novel relationship involving mechanical stimulation and vasodilation in rodent and human skin, referred to as pressure-induced vasodilation (PIV). It is unknown whether this mechanism exists in kidney and reflects the microcirculation in deep organs. Therefore, we compared the skin and kidney PIV to determine whether their changes were similar. METHODS: In anesthetized mice fed a normal salt-diet, laser Doppler flux (LDF) signals were measured when an increase in local pressure was applied to the surface of the head skin with the rate of 2...
August 30, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28847705/an-effective-model-of-cerebrovascular-pressure-reactivity-and-blood-flow-autoregulation
#14
Sebastián Acosta, Daniel J Penny, Ken M Brady, Craig G Rusin
Understanding cerebral blood flow dynamics is crucial for the care of patients at risk of poor cerebral perfusion. We describe an effective model of cerebral hemodynamics designed to reveal important macroscopic features of cerebral blood flow without having to resolve the detailed microvasculature of the brain. Based on principles of fluid and elastic dynamics and vascular pressure-reactivity, the model quantifies the physical means by which the vasculature executes autoregulatory reflexes. We demonstrate that the frequency response of the proposed model matches experimental measurements and explains the influence of mechanical factors on the autoregulatory performance...
August 25, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28842183/pronounced-and-sustained-cutaneous-vasoconstriction-during-and-following-cyrotherapy-treatment-role-of-neurotransmitters-released-from-sympathetic-nerves
#15
Kevin M Christmas, Jordan C Patik, Sepideh Khoshnevis, Kenneth R Diller, R Matthew Brothers
Cryotherapy is a therapeutic technique using ice or cold water applied to the skin to manage soft tissue trauma and injury. While beneficial, there are some potentially detrimental side effects, such as pronounced vasoconstriction and tissue ischemia that are sustained for hours post-treatment. This study tested the hypothesis that this vasoconstriction is mediated by 1) activation of post-synaptic α-adrenergic receptors and/or 2) activation of post-synaptic neuropeptide Y1 (NPY Y1) receptors. 8 subjects were fitted with a commercially available cryotherapy unit with a water perfused bladder on the lateral portion of the right calf...
January 2018: Microvascular Research
https://www.readbyqxmd.com/read/28782513/the-effect-of-age-on-the-response-of-retinal-capillary-filling-to-changes-in-intraocular-pressure-measured-by-optical-coherence-tomography-angiography
#16
Xiaoyun Jiang, Elaine Johnson, William Cepurna, Diana Lozano, Shaojie Men, Ruikang K Wang, John Morrison
PURPOSE: To compare the effect of elevated intraocular pressure (IOP) on retinal capillary filling in elderly vs adult rats using optical coherence tomography angiography (OCTA). METHODS: The IOP of elderly (24-month-old, N=12) and adult (6-8month-old, N=10) Brown Norway rats was elevated in 10mmHg increments from 10 to 100mmHg. At each IOP level, 3D OCT data were captured using an optical microangiography (OMAG) scanning protocol and then post-processed to obtain both structural and vascular images...
January 2018: Microvascular Research
https://www.readbyqxmd.com/read/28834709/correlations-between-blood-perfusion-and-dermal-thickness-in-different-skin-areas-of-systemic-sclerosis-patients
#17
B Ruaro, A Sulli, C Pizzorni, S Paolino, V Smith, E Alessandri, A C Trombetta, J Alsheyyab, M Cutolo
OBJECTIVE: To identify possible correlations between skin blood perfusion (BP) and dermal thickness (DT) in different skin areas of systemic sclerosis (SSc) patients. METHODS: Sixty-two SSc patients, according to 2013 EULAR/ACR criteria, and 62 healthy subjects (CNT) were enrolled. Skin BP was analysed by laser speckle contrast analysis (LASCA) at the level of dorsum of the middle phalanx of the third fingers, dorsal aspect of the hands and zygoma. DT was assessed by both skin high frequency ultrasound (US) and modified Rodnan skin score (mRSS) in the same above reported areas...
August 20, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28830763/carvacrol-promotes-angiogenic-paracrine-potential-and-endothelial-differentiation-of-human-mesenchymal-stem-cells-at-low-concentrations
#18
Danial Matluobi, Atefeh Araghi, Behnaz Faramarzian Azimi Maragheh, Aysa Rezabakhsh, Sina Soltani, Majid Khaksar, Vahid Siavashi, Adel Feyzi, Hesam Saghaei Bagheri, Reza Rahbarghazi, Soheila Montazersaheb
OBJECTIVES: Phenolic monoterpene compound, named Carvacrol, has been found to exert different biological outcomes. It has been accepted that the angiogenic activity of human mesenchymal stem cells was crucial in the pursuit of appropriate regeneration. In the current experiment, we investigated the contribution of Carvacrol on the angiogenic behavior of primary human mesenchymal stem cells. METHODS: Mesenchymal stem cells were exposed to Carvacrol in a dose ranging from 25 to 200μM for 48h...
August 19, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28818494/gts-21-reduces-microvascular-permeability-during-experimental-endotoxemia
#19
Karsten Schmidt, Sukanya Bhakdisongkhram, Florian Uhle, Christoph Philipsenburg, Aleksandar R Zivkovic, Thorsten Brenner, Johann Motsch, Markus A Weigand, Stefan Hofer
INTRODUCTION: No effective pharmacological therapy is currently available to attenuate tissue edema formation due to increased microvascular permeability in sepsis. Cholinergic mediators have been demonstrated to exert anti-inflammatory effects via the α7 nicotinic acetylcholine receptor (α7nAChR) during inflammation. GTS-21, a partial α7nAChR agonist, is an appealing therapeutic substance for sepsis-induced microvascular inflammation due to its demonstrated cholinergic anti-inflammatory properties and its favorable safety profile in clinical trials...
August 15, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28772105/transient-endothelial-dysfunction-induced-by-sugar-sweetened-beverage-consumption-may-be-attenuated-by-a-single-bout-of-aerobic-exercise
#20
Pia Varsamis, Guillaume Walther, Bianca Share, Frances Taylor, Simon Stewart, Christian Lorenzen, Jordan Loader
BACKGROUND: This study assessed whether aerobic exercise would attenuate microvascular endothelial dysfunction induced by commercial sugar-sweetened beverage (SSB) consumption. METHODS: Eleven healthy males participated in this randomized, single-blind crossover study. Cutaneous microvascular endothelial function was assessed using laser speckle contrast imaging coupled with post-occlusive reactive hyperemia before and after a) consumption of water; b) consumption of a commercial SSB; c) 30min of aerobic exercise followed by water consumption; and d) 30 minutes of aerobic exercise followed by SSB consumption...
July 31, 2017: Microvascular Research
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