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FEBS Letters

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https://www.readbyqxmd.com/read/29790176/tau-filaments-in-neurodegenerative-diseases
#1
Michel Goedert
The ordered assembly of Tau protein into abnormal filamentous inclusions is a defining characteristic of many human neurodegenerative diseases. Thirty years ago, we reported that Tau is an integral component of the intraneuronal filaments of Alzheimer's disease. All six brain Tau isoforms make up those filaments. Twenty years ago, we and others showed that mutations in MAPT, the Tau gene, cause familial forms of frontotemporal dementia, thus proving that dysfunction of Tau protein is sufficient to cause neurodegeneration and dementia...
May 22, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29790175/mechanisms-of-cell-regulation-proteolysis-the-big-surprise
#2
Dieter H Wolf, Ruth Menssen
Precise regulation of cellular processes is essential for life. Concerning proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g. phosphorylation), enzyme activation or inhibition by small molecules, and modulation of protein-protein interactions. Complete removal of a protein via proteolysis as a regulatory mechanism, however, was denied for a long time, mainly due to economical considerations. Scientists could not believe that a protein which is synthesized at the expense of a lot of energy could be destroyed again...
May 22, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29790167/beware-of-memes-in-the-interpretation-of-your-results-lessons-from-gene-disrupted-mice-in-fertilization-research
#3
Masaru Okabe
For decades, researchers in the fertilization field reported various candidate factors involved in sperm-egg interaction through experiments using enzyme inhibitors and/or antibodies. However, almost all of these factors have been shown to be nonessential by gene-disruption experiments. Recently, attention has focused on the low reproducibility of papers in many research fields. In this Review, I retrospectively revisit how fertilization factors were misinterpreted and led to wrong hypotheses in relation to the reportedly low reproducibility of scientific papers...
May 22, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29790151/irreversible-modifications-of-receptor-tyrosine-kinases
#4
Matthew Kreitman, Ashish Noronha, Yosef Yarden
Each group of the 56 receptor tyrosine kinases (RTK) binds with one or more soluble growth factors and coordinates a vast array of cellular functions. These outcomes are tightly regulated by inducible post-translational events, such as tyrosine phosphorylation, ubiquitination, ectodomain shedding and regulated intramembrane proteolysis. Because of the delicate balance required for appropriate RTK function, cells may become pathogenic upon dysregulation of RTKs themselves or their post-translational covalent modifications...
May 22, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782654/ddx3x-rna-helicase-affects-breast-cancer-cell-cycle-progression-by-regulating-expression-of-klf4
#5
LETTER
Ester Cannizzaro, Andrew John Bannister, Namshik Han, Andrej Alendar, Tony Kouzarides
DDX3X is a multifunctional RNA helicase with documented roles in different cancer types. Here, we demonstrate that DDX3X plays an oncogenic role in breast cancer cells by modulating the cell cycle. Depletion of DDX3X in MCF7 cells slows cell proliferation by inducing a G1 phase arrest. Notably, DDX3X inhibits expression of Kruppel-like factor 4 (KLF4), a transcription factor and cell cycle repressor. Moreover, DDX3X directly interacts with KLF4 mRNA and regulates its splicing. We show that DDX3X-mediated repression of KLF4 promotes expression of S-phase inducing genes in MCF7 breast cancer cells...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782652/adenosine-methylation-as-a-molecular-imprint-defining-the-fate-of-rna
#6
REVIEW
Philip Knuckles, Marc Bühler
Multiple lines of evidence suggest the RNA modification N6 -methyladonsine (m6 A), which is installed in the nucleus co-transcriptionally and, thereafter, serves as a reversible chemical imprint that influences several steps of mRNA metabolism. This includes but is not limited to RNA folding, splicing, stability, transport, and translation. In this Review we focus on the current view of the nuclear installation of m6 A as well the molecular players involved, the so called m6 A writers. We also explore the effector proteins, or m6 A readers, that decode the imprint in different cellular contexts and compartments, and ultimately, the way the modification influences the lifecycle of an RNA molecule...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782647/cyclin-e2-cdk2-mediate-samhd1-phosphorylation-to-abrogate-its-restriction-of-hbv-replication-in-hepatoma-cells
#7
LETTER
Jie Hu, Miao Qiao, Yanmeng Chen, Hua Tang, Wenlu Zhang, Dan Tang, Sidie Pi, Juan Dai, Ni Tang, Ailong Huang, Yuan Hu
SAMHD1 inhibits Hepatitis B virus (HBV) replication by reducing the intracellular dNTP levels. However, how SAMHD1 phosphorylation is regulated to abrogate its restriction of HBV replication in hepatoma cells is poorly understood. Here, we show that HBV replication and SAMHD1 phosphorylation levels are significantly reduced by knocking down cyclin-dependent kinase (CDK) 2 expression or in the presence of a CDK2 inhibitor. SAMHD1 binds to CDK2 in hepatocarcinoma cells, and this interaction does not require the HBV core protein...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782646/cullin3-kctd5-induces-mono-ubiquitination-of-%C3%AE-np63%C3%AE-and-impairs-its-activity
#8
LETTER
Hanbing He, Yougong Peng, Shijie Fan, Yonglong Chen, Xuan Zheng, Chenghua Li
Potassium channel tetramerization domain containing 5 (KCTD5) was previously documented as a component of the Cullin3-RING ligase (CRL3). It has been reported that KCTD5 can induce enrichment of poly-ubiquitinated proteins, and KCTD5-based CRL3 destabilizes several proteins. In our present study, we report that KCTD5 may physically interact with ΔNp63α, which is a member of the p53 family. Our further investigation revealed that Cullin3/KCTD5 can induce mono-ubiquitination of ΔNp63α. Cullin3/KCTD5 down-regulates the DNA-binding affinity of ΔNp63α, impairing either its transactivity or its trans-inhibitory activity...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782638/sensing-and-transducing-forces-in-plants-with-msl10-and-dek1-mechanosensors
#9
REVIEW
Yannick Guerringue, Sébastien Thomine, Jean-Marie Frachisse
Mechanosensitive (MS) channels behave as micro-probes that transduce mechanical tension into electric and ion signals. The plasma membrane anion-permeant channel AtMSL10 belongs to the first family of MS channels (MscS-LIKE) that has been characterized in Arabidopsis thaliana. In the same membrane, a rapidly activated calcium MS channel activity (RMA) associated with the presence of the DEFECTIVE KERNEL1 (AtDEK1) protein has been recently described. In this Review, based on the comparison of the specific properties of AtMSL10 and RMA, we put forward hypotheses on the mechanism of activation of these two channels, their respective roles in signaling, and also raise the question of the molecular identity of RMA...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782033/the-membrane-bound-o-acyltransferase-ale1-transfers-an-acyl-moiety-to-newly-synthesized-2-alkyl-sn-glycero-3-phosphocholine-in-yeast
#10
LETTER
Shiho Morisada, Yusuke Ono, Teruhisa Kodaira, Hideyuki Kishino, Ryo Ninomiya, Naoki Mori, Hidenori Watanabe, Akinori Ohta, Hiroyuki Horiuchi, Ryouichi Fukuda
To elucidate the mechanism of acyl chain remodeling at the sn-1 position of phosphatidylcholine, we investigated acyl chain introduction using a newly-synthesized 1-hydroxy-2-hexadecyl-sn-glycero-3-phosphocholine (HHPC) in Saccharomyces cerevisiae. HHPC is incorporated into yeast cells and converted to a phosphatidylcholine (PC) species containing acyl residues of 16 or 18 carbons. The efficiency of palmitoleic acid introduction to HHPC in vitro is lower in the reaction with the extract from the deletion mutant of ALE1, which encodes a membrane-bound O-acyltransferase, than in that with extracts from the wild-type strain...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29774536/development-of-a-bsd-blasticidin-selection-system-in-plasmodium-berghei
#11
LETTER
Akira Soga, Mami Ko-Ketsu, Shinya Fukumoto
Plasmodium berghei is used as a rodent model for the study of malaria. However, multiple genetic manipulations are restricted by the paucity of selectable markers. The bsd-blasticidin selection system is widely used for eukaryotic cells; however, it could not previously be used for P. berghei due to toxicity to the rodent host. Here, we report the application of this selection system in P. berghei using an in vitro selection method. The desired bsd integrated mutants are enriched by more than 90% within two weeks when using this system...
May 17, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29772612/activity-and-structure-of-human-acetyl-coa-carboxylase-targeted-by-a-specific-inhibitor
#12
REVIEW
SoRi Jang, Piotr Gornicki, Jasmina Marjanovic, Ethan Bass, Toni Lurcotta, Pedro Rodriguez, Jotham Austin, Robert Haselkorn
We have studied a series of human acetyl CoA-carboxylase (ACC) 1 and ACC2 proteins with deletions and/or Ser to Ala substitutions of the known phosphorylation sites. In vitro dephosphorylation/phosphorylation experiments reveal a substantial level of phosphorylation of human ACCs produced in insect cells. Our results are consistent with AMPK phosphorylation of Ser29, Ser80 , Ser1,201 and Ser1,216 . Phosphorylation of the N-terminal regulatory domain decreases ACC1 activity, while phosphorylation of residues in the ACC central domain has no effect...
May 17, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29772604/signal-sequence-independent-targeting-of-mid2-mrna-to-the-endoplasmic-reticulum-by-the-yeast-rna-binding-protein-khd1p
#13
LETTER
Muhammad Ibrahim Syed, Balaji T Moorthy, Andreas Jenner, Ingrid Fetka, Ralf-Peter Jansen
Localization of mRNAs depends on specific RNA-binding proteins (RBPs) and critically contributes not only to cell polarization but also to basal cell function. The yeast RBP Khd1p binds to several hundred mRNAs, the majority of which encodes secreted or membrane proteins. We demonstrate that a subfraction of Khd1p associates with artificial liposomes and endoplasmic reticulum (ER), and that Khd1p endomembrane association is partially dependent on its binding to RNA. ER targeting of at least two mRNAs, MID2 and SLG1/WSC1, requires KHD1 but is independent of their translation...
May 17, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29772603/a-novel-amyloid-designable-scaffold-and-potential-inhibitor-inspired-by-gaiig-of-amyloid-beta-and-the-hiv-1-v3-loop
#14
LETTER
C Kokotidou, S V R Jonnalagadda, A A Orr, M Seoane-Blanco, C P Apostolidou, M J van Raaij, M Kotzabasaki, A Chatzoudis, J M Jakubowski, E Mossou, V T Forsyth, E P Mitchell, M W Bowler, A L Llamas-Saiz, P Tamamis, A Mitraki
The GAIIG sequence, common to the amyloid beta peptide (residues 29-33) and to the HIV gp 120 (residues 24-28 in a typical V3 loop) self-assembles into amyloid fibrils, as suggested by theory and the experiments presented here. The longer YATGAIIGNII sequence from the V3 loop also self-assembles into amyloid fibrils, of which the first three and the last two residues are outside the amyloid GAIIG core. We postulate that this sequence, with suitable selected replacements at the flexible positions, can serve as a designable scaffold for novel amyloid-based materials...
May 17, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29772070/alternative-utrophin-mrnas-contribute-to-phenotypic-differences-between-dystrophin-deficient-mice-and-duchenne-muscular-dystrophy
#15
LETTER
Kelly J Perkins, Kay E Davies
Duchenne muscular dystrophy (DMD) is a fatal disorder caused by absence of functional dystrophin. Compensation in dystrophin-deficient (mdx) mice may be achieved by overexpression of its foetal paralogue, utrophin. Strategies to increase utrophin levels by stimulating promoter activity using small compounds are therefore a promising pharmacological approach. Here, we characterise similarities and differences existing within the mouse and human utrophin locus to assist in high-throughput screening for potential utrophin modulator drugs...
May 17, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29770436/all-i-s-on-the-radar-role-of-adar-in-gene-regulation
#16
REVIEW
Galina Shevchenko, Kevin V Morris
Adenosine to inosine (A-to-I) editing is the most abundant form of RNA modification in mammalian cells, which is catalyzed by adenosine deaminase acting on the double-stranded RNA (ADAR) protein family. A-to-I editing is currently known to be involved in the regulation of the immune system, RNA splicing, protein recoding, microRNA biogenesis, and formation of heterochromatin. Editing occurs within regions of double-stranded RNA, particularly within inverted Alu repeats, and is associated with many diseases including cancer, neurological disorders, and metabolic syndromes...
May 16, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29766495/inext-a-european-facility-network-to-stimulate-translational-structural-biology
#17
LETTER
(no author information available yet)
No abstract text is available yet for this article.
May 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29754461/computational-modeling-highlights-disordered-formin-homology-1-domain-s-role-in-profilin-actin-transfer
#18
LETTER
Brandon G Horan, Gül H Zerze, Young C Kim, Dimitrios Vavylonis, Jeetain Mittal
Formins accelerate actin polymerization, assumed to occur through flexible FH1 domain mediated transfer of profilin-actin to the barbed end. To study FH1 properties and address sequence effects including varying length/distributionof profilin-binding proline-rich motifs, we performed allatom simulations of mouse mDia1, mDia2; budding yeast Bni1, Bnr1; fission yeast Cdc12, For3, and Fus1 FH1s. We find FH1 has flexible regions between high propensity polyproline helix regions. A coarse-grained model retaining sequence-specificity, assuming rigid polyproline segments,describes their size...
May 13, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29754429/structural-characterizations-of-human-periostin-dimerization-and-cysteinylation
#19
LETTER
Jianmei Liu, Junying Zhang, Fei Xu, Zhaohan Lin, Zhiqiang Li, Heli Liu
Human periostin plays a multifaceted role in remodeling the extracellular matrix milieu by interacting with other proteins and itself in both a heterophilic and homophilic manner. However, the structural mechanism for its extensive interactions has remained elusive. Here, we report the crystal structures of human periostin (EMI-Fas1I- IV ) and its Cys60Ala mutant. In combination with multi-angle light scattering analysis and biochemical assays, the crystal structures reveal that periostin mainly exists as a dimer in solution and its homophilic interaction is mainly mediated by the EMI domain...
May 12, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29754415/biological-hydropersulfides-and-related-polysulfides-a-new-concept-and-perspective-in-redox-biology
#20
REVIEW
Jon M Fukuto, Louis J Ignarro, Peter Nagy, David A Wink, Christopher G Kevil, Martin Feelisch, Miriam M Cortese-Krott, Christopher L Bianco, Yoshito Kumagai, Adrian J Hobbs, Joseph Lin, Tomoaki Ida, Takaaki Akaike
The chemical biology of thiols (RSH, e.g., cysteine and cysteine containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSSn H, RSSn R, n > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSSn H...
May 12, 2018: FEBS Letters
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