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FEBS Letters

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https://www.readbyqxmd.com/read/29336035/jim-s-view-some-thoughts-for-young-scientists
#1
LETTER
James E Rothman
No abstract text is available yet for this article.
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29334121/the-multipotency-to-commitment-transition-mct-in-c-elegans-implications-for-reprogramming-from-cells-to-organs
#2
REVIEW
Erik A Spickard, Pradeep M Joshi, Joel H Rothman
In animal embryos, cells transition from a multipotential state, with the capacity to adopt multiple fates, into an irreversible, committed state of differentiation. This multipotency-to-commitment transition (MCT) is evident from experiments in which cell fate is reprogrammed by transcription factors for cell-type-specific differentiation, as has been observed extensively in C. elegans. Although factors that direct differentiation into each of the three germ layer types cannot generally reprogram cells after the MCT in this animal, transcription factors for endoderm development are able to do so in multiple differentiated cell types...
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29334120/protein-phosphatase-1-dephosphorylates-tdp-43-and-suppresses-its-function-in-tau-exon-10-inclusion
#3
LETTER
Jianlan Gu, Weihua Wang, Shichen Miao, Feng Chen, Feng Wu, Wen Hu, Khalid Iqbal, Cheng-Xin Gong, Fei Liu
Transactive response DNA-binding protein of 43-kDa (TDP-43) regulates RNA processing, including alternative splicing of tau exon 10. Pathological TDP-43 is hyperphosphorylated. However, the protein phosphatase(s) (PP) that regulates TDP-43 phosphorylation is unclear. Here, we found that both PP1 and PP2A were co-immunoprecipitated with TDP-43. Treatment with calyculin A, but not with okadaic acid, increased TDP-43 phosphorylation at Ser379, Ser403/404, and Ser409/410 in cultured cells. PP1α, PP1β, and PP1γ interacted with TDP-43...
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29332304/the-i3s-initiative-a-portuguese-blend-of-research-and-innovation
#4
LETTER
Maria Papatriantafyllou
No abstract text is available yet for this article.
January 14, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29331030/single-molecule-nucleosome-remodeling-by-ino80-and-effects-of-histone-tails
#5
LETTER
Marianne Schwarz, Kevin Schall, Eleni Kallis, Sebastian Eustermann, Mara Guariento, Manulea Moldt, Karl-Peter Hopfner, Jens Michaelis
Genome maintenance and integrity requires continuous alterations of the compaction state of the chromatin structure. Chromatin remodelers, amongst others the INO80 complex, help organize chromatin by repositioning, reshaping or evicting nucleosomes. We report on INO80 nucleosome remodeling, assayed by single molecule Foerster Resonance Energy Transfer (FRET) on canonical nucleosomes as well as nucleosomes assembled from tailless histones. Nucleosome repositioning by INO80 is a processively catalyzed reaction...
January 13, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29331028/alteration-in-microrna-17-92-dynamics-accounts-for-differential-nature-of-cellular-proliferation
#6
LETTER
Dola Sengupta, Vinodhini Govindaraj, Sandip Kar
MicroRNAs associated with the mir-17-92 cluster are crucial regulators of the mammalian cell cycle, as they inhibit transcription factors related to the E2F family that tightly control decision making events for a cell to commit for active cellular proliferation. Intriguingly, in many solid cancers, these mir-17-92 cluster members are overexpressed, whereas in some hematopoietic cancers they are downregulated. Our proposed model of the Myc/E2F/mir-17-92 network demonstrates that the differential expression pattern of mir-17-92 in different cell types can be conceived due to having a contrasting E2F dynamics induced by mir-17-92...
January 13, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29331018/interplay-of-spkg-kinase-and-the-slr0151-protein-in-the-phosphorylation-of-ferredoxin-5-in-synechocystis-sp-strain-pcc-6803
#7
LETTER
Martina Angeleri, Anna Zorina, Eva-Mari Aro, Natalia Battchikova
In Synechocystis 6803, the ferredoxin 5 (Fd5) phosphoprotein and the S/T protein kinase SpkG are encoded by the slr0148 and slr0152 genes respectively, which belong to the slr0144-slr0152 cluster. Using a targeted proteomic approach, we showed that SpkG is responsible for the phosphorylation of Fd5 on residues T18 and T72. Sequence alignments and Fd5 structure modelling suggest that these phosphorylation events modulate protein-protein interaction. Further, Fd5 phosphorylation is affected by the Slr0151 protein encoded by the gene preceding spkG in the gene cluster...
January 13, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29331016/a-candidate-functional-snp-rs7074440-in-tcf7l2-alters-gene-expression-through-c-fos-in-hepatocytes
#8
LETTER
Xianying Piao, Naoya Yahagi, Yoshinori Takeuchi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Yoshihiko Izumida, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Hitoshi Shimano
The SNP rs7903146 at the transcription factor 7-like 2 (TCF7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome-wide association studies. However, the functional SNPs regulating TCF7L2 expression remain unclear. Here we show that the SNP rs7074440 is a candidate functional SNP highly linked with rs7903146. A reporter plasmid with rs7074440 normal allele sequence exhibited 15-fold higher luciferase activity compared with risk allele sequence in hepatocytes, demonstrating a strong enhancer activity at rs7074440...
January 13, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29325219/molecular-basis-of-the-flavin-based-electron-bifurcating-caffeyl-coa-reductase-reaction
#9
LETTER
Julius K Demmer, Johannes Bertsch, Christian Öppinger, Hannah Wohlers, Kanwal Kayastha, Ulrike Demmer, Ulrich Ermler, Volker Müller
Flavin-based electron bifurcation (FBEB) is a recently discovered mode of energy coupling in anaerobic microorganisms. The electron-bifurcating caffeyl-CoA reductase (CarCDE) catalyzes the reduction of caffeyl-CoA and ferredoxin by oxidizing NADH. The 3.5 Å structure of the heterododecameric Car(CDE)4 complex of Acetobacterium woodii, presented here, reveals compared to other electron transferring flavoprotein/ acyl dehydrogenase family members an additional ferredoxin-like domain with two [4Fe-4S] clusters N-terminally fused to CarE...
January 11, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29323703/integrative-omics-analysis-of-p53-dependent-regulation-of-metabolism
#10
LETTER
Jiajun Huang, Ze Long, Wanjun Lin, Xiaolin Liao, Ying Xie, Liang Liu, Wenzhe Ma
Accumulated evidence in the last decade implies that regulation of metabolism by p53 represents a reviving mechanism vital to prevent tumorigenesis. To gain a more in-depth understanding of metabolic regulation by baseline levels of p53, we employed both metabolomics and transcriptomics analysis with human colon cancer cell line HCT116 depleted of p53. Metabolomics analyses with UPLC/Q-TOF MS identified 283 significantly changed metabolites including 138 important metabolites. Transcriptomics analysis with microarray revealed 1317 differentially expressed genes (DEGs)...
January 11, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29323697/identification-of-a-novel-botulinum-neurotoxin-gene-cluster-in-enterococcus
#11
LETTER
Jason Brunt, Andrew T Carter, Sandra C Stringer, Michael W Peck
The deadly neurotoxins of Clostridium botulinum (BoNTs) comprise eight serotypes (A-G; X). The neurotoxin gene cluster encoding BoNT and its accessory proteins includes an operon containing an ntnh gene upstream of the boNT gene. Another operon contains either ha (haemagglutinin) or orfX genes (of unknown function). Here we describe a novel boNT gene cluster from Enterococcus sp. 3G1_DIV0629, with a typical ntnh gene and an uncommon orfX arrangement. The neurotoxin (designated putative eBoNT/J) contains a metallopeptidase zinc binding site, a translocation domain and a target cell attachment domain...
January 11, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29323696/regulation-of-neuronal-development-and-function-by-ros
#12
REVIEW
Matthew C W Oswald, Nathan Garnham, Sean T Sweeney, Matthias Landgraf
Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease This article is protected by copyright...
January 11, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29292505/reversible-optical-control-of-f1-fo-atp-synthase-using-photoswitchable-inhibitors
#13
LETTER
Bianca Eisel, Felix Hartrampf, Thomas Meier, Dirk Trauner
F1 Fo -ATP synthase is one of the best studied macromolecular machines in nature. It can be inhibited by a range of small molecules, which include the polyphenols resveratrol and piceatannol. Here, we introduce Photoswitchable Inhibitors of ATP Synthase, termed PIAS, which were synthetically derived from these polyphenols. They can be used to reversibly control the enzymatic activity of purified yeast Yarrowia lipolytica ATP synthase by light. Our experiments indicate that the PIAS bind to the same site in the ATP synthase F1 complex as the polyphenols in their trans form but they do not bind in their cis form...
January 1, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29292503/substitution-of-one-calcium-binding-amino-acid-strengthens-substrate-binding-in-a-thermophilic-alginate-lyase
#14
LETTER
Bing Wang, Shi-Qi Ji, Xiao-Qing Ma, Ming Lu, Lu-Shan Wang, Fu-Li Li
Ligand binding is sensitive to temperatures since noncovalent bonds between binding site and ligand could be broken by heat. How metal ion-binding amino acids in alginate lyase evolve to achieve tight substrate binding in a hostile environment remains unknown. An endolytic alginate lyase AlgAT0 specifically cleaved the M-G glycosidic bond and released disaccharides as the main end product. Four conserved calcium-binding sites were predicted and supplement of Ca2+ led to enhanced substrate binding and protein stability...
January 1, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29292499/interaction-between-ror1-and-musk-activation-complex-in-myogenic-cells
#15
LETTER
Hanna Karvonen, Katja Summala, Wilhelmiina Niininen, Harlan R Barker, Daniela Ungureanu
The ROR family of receptor tyrosine kinases, ROR1 and ROR2, is known to play an important role during skeletal muscle regeneration. ROR1 has a critical role in regulating satellite cell (SC) proliferation during muscle regeneration, and pro-inflammatory cytokines such as TNF-α and IL-1β can induce expression of ROR1 in myogenic cells via NF-κB activation. While searching for ROR1-interacting proteins in myogenic cells, we identified MuSK as a ROR1 binding protein. MuSK interacts with and phosphorylates ROR1 at the cytoplasmic proline-rich domain...
January 1, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29292497/disruption-of-wnt-production-in-shh-lineage-causes-bone-malformation-in-mice-mimicking-human-malik-percin-type-syndactyly
#16
LETTER
Xiao-Jing Zhu, Yukun Fang, Yanan Xiong, Min Wang, Xueqin Yang, Yan Li, Xiaoyun Zhang, Zhong-Min Dai, Mengsheng Qiu, Ze Zhang, Zunyi Zhang
Here we show that Shh-Cre-mediated deletion of Wntless, the Wnt cargo protein, in mouse posterior limb mesenchyme causes bone syndactyly of the 3rd and 4th digits, resembling the human Malik-Percin type. The Shh descendants gradiently distributed from digit 5 to posterior half of digit 3 in wild-type limbs, however, they abnormally increased in posterior digit 3 in WntlessShh-Cre . WntlessShh-Cre limbs displayed altered expression of hedgehog pathway genes and impaired non-canonical Wnt signaling activity. We further showed that the anterior limb mesenchymal cells in the WlsShh-Cre served as a source of Wnt5a to reorientate the adjacent Wls-lacking Shh lineage cells to move anteriorly and subsequently led to syndactyly, suggesting that aberrant mesenchymal cell movement/condensation may underlie the pathogenesis of syndactyly...
January 1, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29292494/role-of-mitochondrial-ros-in-the-brain-from-physiology-to-neurodegeneration
#17
REVIEW
Plamena R Angelova, Andrey Y Abramov
Mitochondria are key organelles in the cell, which are responsible for energy production, and control many processes from signalling to cell death. The function of the mitochondrial electron transport chain is coupled with the production of reactive oxygen species (ROS) in the form of superoxide anion or hydrogen peroxide. Due to the constant production of ROS, mitochondria are protected by highly efficient antioxidant systems. The rapidly changing levels of ROS in mitochondria, coupled with multiple essential cellular functions, make ROS apt for physiological signalling...
January 1, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29288497/the-role-of-trna-synthetases-in-neurological-and-neuromuscular-disorders
#18
REVIEW
Veronika Boczonadi, Matthew J Jennings, Rita Horvath
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed enzymes responsible for charging tRNAs with their cognate amino acids, therefore essential for the first step in protein synthesis. Although the majority of protein synthesis happens in the cytosol, an additional translation apparatus is required to translate the 13 mitochondrial DNA-encoded proteins important in oxidative phosphorylation. Most ARS genes in these cellular compartments are distinct, but two genes are common, encoding aminoacyl-tRNA synthetases of glycine (GARS) and lysine (KARS) in both mitochondria and the cytosol...
December 30, 2017: FEBS Letters
https://www.readbyqxmd.com/read/29288494/nuclear-cytochrome-c-a-mitochondrial-visitor-regulating-damaged-chromatin-dynamics
#19
Irene Díaz-Moreno, Alejandro Velázquez-Cruz, Seamus Curran-French, Antonio Díaz-Quintana, Miguel A De la Rosa
Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. Recently, we demonstrated the ability of Cyt c to inhibit the nucleosome assembly activity of histone chaperones SET/TAF-Iβ and NRP1 during DNA damage in humans and plants, respectively. Here, we hypothesise a dual concentration-dependent function for nuclear Cyt c in response to DNA damage. We propose that low levels of highly cytotoxic DNA lesions - such as double-strand breaks - induce nuclear translocation of Cyt c, leading to the attenuation of nucleosome assembly and, thereby, increasing the time available for DNA repair...
December 30, 2017: FEBS Letters
https://www.readbyqxmd.com/read/29282732/restoration-of-cellulase-activity-in-the-inactive-cellulosomal-protein-cel9v-from-ruminiclostridium-cellulolyticum
#20
LETTER
Nicolas Vita, Julie Ravachol, Nathalie Franche, Romain Borne, Chantal Tardif, Sandrine Pagès, Henri-Pierre Fierobe
Ruminiclostridium cellulolyticum produces extracellular cellulosomes which contain inter alia numerous Family-9 Glycoside Hydrolases, including the inactive Cel9V. The latter shares the same organization and 79% sequence identity with the active cellulase Cel9E. Nevertheless two aromatic residues, and a four-residue stretch putatively critical for the activity are missing in Cel9V. Introduction of one Trytophan and the four-residue stretch restored some weak activity in Cel9V, whereas the replacement of its catalytic domain by that of Cel9E generated a fully active cellulase...
December 28, 2017: FEBS Letters
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