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Pflügers Archiv: European Journal of Physiology

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https://www.readbyqxmd.com/read/30229297/to-flourish-or-perish-evolutionary-trips-into-the-sensory-biology-of-plant-herbivore-interactions
#1
REVIEW
Justyna B Startek, Thomas Voets, Karel Talavera
The interactions between plants and their herbivores are highly complex systems generating on one side an extraordinary diversity of plant protection mechanisms and on the other side sophisticated consumer feeding strategies. Herbivores have evolved complex, integrative sensory systems that allow them to distinguish between food sources having mere bad flavors from the actually toxic ones. These systems are based on the senses of taste, olfaction and somatosensation in the oral and nasal cavities, and on post-ingestive chemosensory mechanisms...
September 18, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30219946/stimulation-history-affects-vasomotor-responses-in-rat-mesenteric-arterioles
#2
Bjørn Olav Hald, Rasmus B Sørensen, Preben G Sørensen, Charlotte M Sørensen, Jens Chr Brings Jacobsen
Resistance vessels regulate blood flow by continuously adjusting activity of the wall smooth muscle cells. These cells integrate a variety of stimuli from blood, endothelium, autonomic nerves, and surrounding tissues. Each stimulus elicits an intracellular signaling cascade that eventually influences activation of the contractile machinery. The characteristic time scale of each cascade and the sharing of specific reactions between cascades provide for complex behavior when a vessel receives multiple stimuli...
September 15, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30218374/nad-metabolism-and-the-slc34-family-evidence-for-a-liver-kidney-axis-regulating-inorganic-phosphate
#3
REVIEW
Sawako Tatsumi, Kanako Katai, Ichiro Kaneko, Hiroko Segawa, Ken-Ichi Miyamoto
The solute carrier 34 (SLC34) family of membrane transporters is a major contributor to Pi homeostasis. Many factors are involved in regulating the SLC34 family. The roles of the bone mineral metabolism factors parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) in Pi homeostasis are well studied. Intracellular Pi is thought to be involved in energy metabolism, such as ATP production. Under certain conditions of altered energy metabolism, plasma Pi concentrations are affected by the regulation of a Pi shift into cells or release from the tissues...
September 14, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30209554/correction-to-electroacupuncture-induces-antihyperalgesic-effect-through-endothelin-b-receptor-in-the-chronic-phase-of-a-mouse-model-of-complex-regional-pain-syndrome-type-i
#4
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidral-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
The original version of this article contains an error. The Author Francisco José Cidral-Filho incorrectly listed as Francisco José Cidra-Filho. The correct spelling is presented above. The original article has been corrected.
September 13, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30206706/1-8-cineole-blocks-voltage-gated-l-type-calcium-channels-in-tracheal-smooth-muscle
#5
Átila Pereira-Gonçalves, Francisco Walber Ferreira-da-Silva, Camille Maria de Holanda-Angelin-Alves, Ana Carolina Cardoso-Teixeira, Andrelina Noronha Coelho-de-Souza, José Henrique Leal-Cardoso
1,8-Cineole is a cyclic monoterpenoid used in folk medicine for treatment of numerous respiratory diseases and other infections. 1,8-Cineole has anti-inflammatory, antioxidant, and myorelaxant effects, as well as low toxicity. In the present study, the effects of 1,8-cineole on contractility and voltage-gated calcium channels (VGCC) in tracheal smooth muscle were investigated. Intact and dissociated tracheal smooth muscle were used for muscle contraction and patch-clamp recordings, respectively. In experiments involving muscle contraction, 1,8-cineole potentiated contractions at low concentrations and relaxed contractions induced by isotonic K+ at high concentrations...
September 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30206705/serotonergic-neuron-adf-modulates-avoidance-behaviors-by-inhibiting-sensory-neurons-in-c-elegans
#6
Jiajie Shao, Xiaoyan Zhang, Hankui Cheng, Xiaomin Yue, Wenjuan Zou, Lijun Kang
Serotonin plays an essential role in both the invertebrate and vertebrate nervous systems. ADF, an amphid neuron with dual ciliated sensory endings, is considered to be the only serotonergic sensory neuron in the hermaphroditic Caenorhabditis elegans. This neuron is known to be involved in a range of behaviors including pharyngeal pumping, dauer formation, sensory transduction, and memory. However, whether ADF neuron is directly activated by environmental cues and how it processes these information remains unknown...
September 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30194638/potential-therapeutic-value-of-transient-receptor-potential-channels-in-male-urogenital-system
#7
REVIEW
Gamze Toktanis, Ecem Kaya-Sezginer, Didem Yilmaz-Oral, Serap Gur
Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes including light, mechanical or chemical stimuli, temperature, pH, or osmolarity. TRP channel proteins are a diverse family of proteins that are expressed in many tissues. We debated our recent knowledge about the expression, function, and regulation of TRP channels in the different parts of the male urogenital system in health and disease. Emerging evidence suggests that dysfunction of TRP channels significantly contributes to the pathophysiology of urogenital diseases...
September 7, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30175377/expression-cloning-human-and-rat-renal-cortex-na-p-i-cotransporters-behind-the-scenes-in-the-murer-laboratory
#8
REVIEW
Simona Magagnin, Andreas Werner
In the pre-genomic era, the cloning of a cDNA represented a significant achievement, particularly if the gene of interest encoded a membrane protein. At the time, molecular probes such as partial peptide sequences, suitable nucleic acid sequences, or antibodies were unavailable for most proteins and the "sodium-phosphate transporter" was no exception. In contrast, brush-border membrane vesicles and epithelial cell culture experiments had established a reliable set of functional hallmarks that described Na-dependent phosphate transport activity in some detail...
September 3, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30175376/structural-models-of-the-napi-ii-sodium-phosphate-cotransporters
#9
REVIEW
Cristina Fenollar-Ferrer, Lucy R Forrest
Progress towards understanding the molecular mechanisms of phosphate homeostasis through sodium-dependent transmembrane uptake has long been stymied by the absence of structural information about the NaPi-II sodium-phosphate transporters. For many other coupled transporters, even those unrelated to NaPi-II, internal repeated elements have been revealed as a key feature that is inherent to their function. Here, we review recent structure prediction studies for NaPi-II transporters. Attempts to identify structural templates for NaPi-II transporters have leveraged the structural repeat perspective to uncover an otherwise obscured relationship with the dicarboxylate-sodium symporters (DASS)...
September 3, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30155776/the-voltage-sensitive-cardiac-m-2-muscarinic-receptor-modulates-the-inward-rectification-of-the-g-protein-coupled-ach-gated-k-current
#10
Pedro D Salazar-Fajardo, Iván A Aréchiga-Figueroa, Ana Laura López-Serrano, Julio C Rodriguez-Elias, Javier Alamilla, José A Sánchez-Chapula, Martin Tristani-Firouzi, Ricardo A Navarro-Polanco, Eloy G Moreno-Galindo
The acetylcholine (ACh)-gated inwardly rectifying K+ current (IKACh ) plays a vital role in cardiac excitability by regulating heart rate variability and vulnerability to atrial arrhythmias. These crucial physiological contributions are determined principally by the inwardly rectifying nature of IKACh . Here, we investigated the relative contribution of two distinct mechanisms of IKACh inward rectification measured in atrial myocytes: a rapid component due to KACh channel block by intracellular Mg2+ and polyamines; and a time- and concentration-dependent mechanism...
August 28, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30155775/glucose-regulated-protein-78-in-lipid-rafts-elevates-vascular-smooth-muscle-cell-proliferation-of-spontaneously-hypertensive-rats-by-controlling-platelet-derived-growth-factor-receptor-signaling
#11
Do-Yoon Kim, Dae Il Hwang, Soo Min Park, Seung Hyo Jung, Bokyung Kim, Kyung Jong Won, Hwan Myung Lee
The multifunctional glucose-regulated protein 78 (GRP78) is known to be differentially expressed in the lipid rafts of vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) and normal Wistar-Kyoto (WKY) rats. However, its role in VSMCs from SHRs remains to be elucidated. This work was conducted to investigate the contribution made by GRP78 in VSMCs. GRP78 expression in VSMC lipid rafts decreased in WKY rats with age, but not in SHRs. Transfection with GRP78-siRNA attenuated not only platelet-derived growth factor (PDGF)-BB-induced VSMC proliferation and aortic sprout outgrowth but also the phosphorylation of PDGF receptor (PDGFR)-β, Akt, and extracellular signal-regulated kinase (Erk) 1/2 in VSMCs in response to PDGF-BB...
August 28, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30140954/renal-expression-and-urinary-excretion-of-na-dicarboxylate-cotransporter-1-nadc1-in-obstructive-nephropathy-a-candidate-biomarker-for-this-pathology
#12
Romina V Campagno, María J Severin, Evangelina C Nosetto, Anabel Brandoni, Adriana Mónica Torres
Obstructive nephropathy is characterized by alterations in renal function that depends on the degree and type of obstruction. To increase the knowledge about the physiopathological mechanisms involved in the renal damage associated with bilateral ureteral obstruction (BUO), we studied the renal expression and function (as urinary citrate excretion) of sodium-dependent dicarboxylate cotransporter (NaDC1) in rats. In addition, we evaluated the urinary excretion of NaDC1 as a candidate biomarker for this pathology...
August 23, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30120555/catalase-and-nonalcoholic-fatty-liver-disease
#13
REVIEW
Su-Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Dae-Kyu Song
Obesity and insulin resistance are considered the main causes of nonalcoholic fatty liver disease (NAFLD), and oxidative stress accelerates the progression of NAFLD. Free fatty acids, which are elevated in the liver by obesity or insulin resistance, lead to incomplete oxidation in the mitochondria, peroxisomes, and microsomes, leading to the production of reactive oxygen species (ROS). Among the ROS generated, H2 O2 is mainly produced in peroxisomes and decomposed by catalase. However, when the H2 O2 concentration increases because of decreased expression or activity of catalase, it migrates to cytosol and other organelles, causing cell injury and participating in the Fenton reaction, resulting in serious oxidative stress...
August 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30116893/transcripts-of-kv7-1-and-mink-channels-and-slow-delayed-rectifier-k-current-i-ks-are-expressed-in-zebrafish-danio-rerio-heart
#14
Denis V Abramochkin, Minna Hassinen, Matti Vornanen
Zebrafish are increasingly used as a model for human cardiac electrophysiology, arrhythmias, and drug screening. However, K+ ion channels of the zebrafish heart, which determine the rate of repolarization and duration of cardiac action potential (AP) are still incompletely known and characterized. Here, we provide the first evidence for the presence of the slow component of the delayed rectifier K+ channels in the zebrafish heart and characterize electrophysiological properties of the slow component of the delayed rectifier K+ current, IKs ...
August 16, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30109411/untying-the-knot-protein-quality-control-in-inherited-cardiomyopathies
#15
REVIEW
Larissa M Dorsch, Maike Schuldt, Dora Knežević, Marit Wiersma, Diederik W D Kuster, Jolanda van der Velden, Bianca J J M Brundel
Mutations in genes encoding sarcomeric proteins are the most important causes of inherited cardiomyopathies, which are a major cause of mortality and morbidity worldwide. Although genetic screening procedures for early disease detection have been improved significantly, treatment to prevent or delay mutation-induced cardiac disease onset is lacking. Recent findings indicate that loss of protein quality control (PQC) is a central factor in the disease pathology leading to derailment of cellular protein homeostasis...
August 14, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30109410/hereditary-hypophosphatemic-rickets-with-hypercalciuria-pathophysiology-clinical-presentation-diagnosis-and-therapy
#16
REVIEW
Clemens Bergwitz, Ken-Ichi Miyamoto
Hereditary hypophosphatemic rickets with hypercalciuria (HHRH; OMIM: 241530) is a rare autosomal recessive disorder with an estimated prevalence of 1:250,000 that was originally described by Tieder et al. Individuals with HHRH carry compound-heterozygous or homozygous (comp/hom) loss-of-function mutations in the sodium-phosphate co-transporter NPT2c. These mutations result in the development of urinary phosphate (Pi) wasting and hypophosphatemic rickets, bowing, and short stature, as well as appropriately elevated 1,25(OH)2 D levels, which sets this fibroblast growth factor 23 (FGF23)-independent disorder apart from the more common X-linked hypophosphatemia...
August 14, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30105595/slc2a9-glut9-mediates-urate-reabsorption-in-the-mouse-kidney
#17
Muriel Auberson, Sophie Stadelmann, Candice Stoudmann, Klaus Seuwen, Robert Koesters, Bernard Thorens, Olivier Bonny
Uric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function mutations have familial renal hypouricemia type 2, a condition characterized by hypouricemia, UA renal wasting associated with kidney stones, and an increased propensity to acute renal failure during strenuous exercise. Mice carrying a deletion of GLUT9 in the whole body are hyperuricemic and display a severe nephropathy due to intratubular uric acid precipitation...
August 13, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30099632/loss-of-function-of-nav1-8-d1639n-linked-to-human-pain-can-be-rescued-by-lidocaine
#18
Luisa Kaluza, Jannis E Meents, Martin Hampl, Corinna Rösseler, Petra A I Hautvast, Silvia Detro-Dassen, Ralf Hausmann, Günther Schmalzing, Angelika Lampert
Mutations in voltage-gated sodium channels are associated with altered pain perception in humans. Most of these mutations studied to date present with a direct and intuitive link between the altered electrophysiological function of the channel and the phenotype of the patient. In this study, we characterize a variant of Nav1.8, D1639N, which has been previously identified in a patient suffering from the chronic pain syndrome "small fiber neuropathy". Using a heterologous expression system and patch-clamp analysis, we show that Nav1...
August 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30099631/unraveling-obscurins-in-heart-disease
#19
REVIEW
Alyssa Grogan, Aikaterini Kontrogianni-Konstantopoulos
Obscurins, expressed from the single OBSCN gene, are a family of giant, modular, cytoskeletal proteins that play key structural and regulatory roles in striated muscles. They were first implicated in the development of heart disease in 2007 when two missense mutations were found in a patient diagnosed with hypertrophic cardiomyopathy (HCM). Since then, the discovery of over a dozen missense, frameshift, and splicing mutations that are linked to various forms of cardiomyopathy, including HCM, dilated cardiomyopathy (DCM), and left ventricular non-compaction (LVNC), has highlighted OBSCN as a potential disease-causing gene...
August 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30094478/electroacupuncture-induces-antihyperalgesic-effect-through-endothelin-b-receptor-in-the-chronic-phase-of-a-mouse-model-of-complex-regional-pain-syndrome-type-i
#20
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidral-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
Complex regional pain syndrome (CRPS) is a disorder that involves abnormal inflammation and nerve dysfunction frequently resistant to a broad range of treatments. Peripheral nerve stimulation with electroacupuncture (EA) has been widely used in different clinical conditions to control pain and inflammation; however, the use of EA in the treatment of CRPS is under investigation. In this study, we explore the effects of EA on hyperalgesia and edema induced in an animal model of chronic post-ischemia pain (CPIP model) and the possible involvement of endothelin receptor type B (ETB ) in this effect...
August 10, 2018: Pflügers Archiv: European Journal of Physiology
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