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Pflügers Archiv: European Journal of Physiology

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https://www.readbyqxmd.com/read/28439717/negligible-effect-of-enos-palmitoylation-on-fatty-acid-regulation-of-contraction-in-ventricular-myocytes-from-healthy-and-hypertensive-rats
#1
Chun Li Jin, Yu Na Wu, Ji Hyun Jang, Zai Hao Zhao, Goo Taeg Oh, Sung Joon Kim, Yin Hua Zhang
S-palmitoylation is an important post-translational modification that affects the translocation and the activity of target proteins in a variety of cell types including cardiomyocytes. Since endothelial nitric oxide synthase (eNOS) is known to be palmitoylated and the activity of eNOS is essential in fatty acid-dependent β-oxidation in muscle, we aimed to test whether palmitoylation of eNOS is involved in palmitic acid (PA) regulation of left ventricular (LV) myocyte contraction from healthy (sham) and hypertensive (HTN) rats...
April 25, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28434061/the-sources-of-calcium-for-noradrenaline-induced-contraction-in-the-human-thoracic-internal-artery
#2
Leszek Buzun, Beata Modzelewska, Anna Kostrzewska, Ewa Kleszczewska, Tomasz Kleszczewski
The aim of the present study was to examine the contribution of intracellular and extracellular calcium sources in contraction caused by noradrenaline (NA) of the human internal thoracic artery (ITA) in vitro. Distal segments of ITA were obtained from 20 patients (aged 38-73, at the time of routine coronary artery surgical revascularization (CABG)). Contractile responses to 10(-6) mol/L NA in the physiological salt solution and in Ca(2+)-free solution without and after incubation with 10(-6) mol/L thapsigargin (TSG) were recorded under isometric conditions...
April 22, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28429070/properties-of-synchronous-spontaneous-ca-2-transients-in-the-mural-cells-of-rat-rectal-arterioles
#3
Retsu Mitsui, Hikaru Hashitani
Synchrony of spontaneous Ca(2+) transients among venular mural cells (smooth muscle cells and pericytes) in visceral organs relies on the intercellular spread of L-type voltage-dependent Ca(2+) channel (LVDCC)-dependent depolarisations. However, the mechanisms underlying the synchrony of spontaneous Ca(2+) transients between arteriolar mural cells are less understood. The spontaneous intracellular Ca(2+) dynamics of arteriolar mural cells in the rat rectal submucosa were visualised by Cal-520 Ca(2+) imaging to analyse their synchrony...
April 21, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28405802/vasculo-protective-effect-of-bms-309403-is-independent-of-its-specific-inhibition-of-fatty-acid-binding-protein-4
#4
Yuta Okamura, Kosuke Otani, Akihiro Sekiguchi, Taisuke Kogane, Chiharu Kakuda, Yuzaburo Sakamoto, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki
Fatty acid-binding protein (FABP) 4 is an adipocytokine mainly expressed in adipocyte and macrophage. Blood FABP4 is related not only to metabolic disorders including insulin resistance and atherosclerosis but also increased blood pressure. We tested the hypothesis that FABP4 plays roles in pathogenesis of hypertension development including proliferation, migration, and inflammation of vascular smooth muscle cells (SMCs) as well as contractile reactivity. FABP4 alone had no influence on proliferation, migration, and inflammation of rat mesenteric arterial SMCs, while it significantly enhanced smooth muscle contraction and increases of systolic blood pressure (SBP) induced by noradrenaline (NA)...
April 13, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28405801/urine-exosomes-from-healthy-and-hypertensive-pregnancies-display-elevated-level-of-%C3%AE-subunit-and-cleaved-%C3%AE-and-%C3%AE-subunits-of-the-epithelial-sodium-channel-enac
#5
Maria R Nielsen, Britta Frederiksen-Møller, Rikke Zachar, Jan S Jørgensen, Mie R Hansen, Rikke Ydegaard, Per Svenningsen, Kristian Buhl, Boye L Jensen
Preeclampsia is characterized by hypertension, proteinuria, suppression of plasma renin-angiotensin-aldosterone, and impaired urine sodium excretion. Aberrantly filtered plasmin in urine may activate proteolytically the γ-subunit of the epithelial sodium channel (ENaC) and promote Na(+) reabsorption and urine K(+) loss. Plasma and urine was sampled from patients with preeclampsia, healthy pregnant controls and non-pregnant women, and from patients with nephrostomy catheters. Aldosterone concentration, urine plasminogen, and protein were determined...
April 12, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28389776/senotherapy-growing-old-and-staying-young
#6
REVIEW
Roland Schmitt
Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair. Instead, senescent cells disturb the microenvironment by secreting a plethora of bioactive factors that may lead to inflammation, regenerative dysfunction and tumor progression. Recent understanding of stimuli and pathways that induce and maintain cellular senescence offers the possibility to selectively eliminate senescent cells...
April 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28389775/erratum-to-sensitisation-of-trpv4-by-par2-is-independent-of-intracellular-calcium-signalling-and-can-be-mediated-by-the-biased-agonist-neutrophil-elastase
#7
Silvia Sostegni, Alexei Diakov, Peter McIntyre, Nigel Bunnett, Christoph Korbmacher, Silke Haerteis
No abstract text is available yet for this article.
April 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28386636/dynamic-monitoring-of-gi-o-protein-mediated-decreases-of-intracellular-camp-by-fret-based-epac-sensors
#8
Ursula Storch, Julie Straub, Serap Erdogmus, Thomas Gudermann, Michael Mederos Y Schnitzler
Analysis of G-protein-coupled receptor (GPCR) signaling, in particular of the second messenger cAMP that is tightly controlled by Gs- and Gi/o-proteins, is a central issue in biomedical research. The classical biochemical method to monitor increases in intracellular cAMP concentrations consists of a radioactive multicellular assay, which is well established, highly sensitive, and reproducible, but precludes continuous spatial and temporal assessment of cAMP levels in single living cells. For this purpose, Förster resonance energy transfer (FRET)-based Epac cAMP sensors are well suitable...
April 6, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28382481/anion-exchange-through-band-3-protein-in-canine-leishmaniasis-at-different-stages-of-disease
#9
Rossana Morabito, Alessia Remigante, Mauro Cavallaro, Alessandro Taormina, Giuseppina La Spada, Angela Marino
Band 3 protein efficiency in mediating Cl(-)/HCO3(-) exchange through erythrocytes membrane is reduced by oxidative stress. The aim of the present study was to verify whether and how anion transport through band 3 protein may be useful in monitoring canine leishmaniasis (Leishmania infantum) development, a disease associated to membrane protein degradation and oxidative stress. To accomplish this aim, serological analysis to determine IFAT (immunofluorescence antibody test) titers against leishmaniasis has been performed and 1:160 and 1:540 titers, determined at diagnosis and after 6 months, were considered for experiments...
April 5, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28382480/biology-of-pancreatic-stellate-cells-more-than-just-pancreatic-cancer
#10
REVIEW
Pawel E Ferdek, Monika A Jakubowska
Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a pivotal role in the desmoplastic reaction present in severe pancreatic disorders. In recent years, enormous scientific effort has been devoted to understanding their roles in pancreatic cancer, which continues to remain one of the most deadly diseases. Therefore, it is not surprising that considerably less attention has been given to studying physiological functions of pancreatic stellate cells...
April 5, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28378089/interleukin-13-increases-pendrin-abundance-to-the-cell-surface-in-bronchial-nci-h292-cells-via-rho-actin-signaling
#11
Annamaria Russo, Marianna Ranieri, Annarita Di Mise, Silvia Dossena, Tommaso Pellegrino, Emilia Furia, Charity Nofziger, Lucantonio Debellis, Markus Paulmichl, Giovanna Valenti, Grazia Tamma
Interleukin-13 (IL13) is a major player in the development of airway hyperresponsiveness in several respiratory disorders. Emerging data suggest that an increased expression of pendrin in airway epithelia is associated with elevated airway hyperreactivity in asthma. Here, we investigate the effect of IL13 on pendrin localization and function using bronchiolar NCI-H292 cells. The data obtained revealed that IL13 increases the cell surface expression of pendrin. This effect was paralleled by a significant increase in the intracellular pH, possibly via indirect stimulation of NHE...
April 4, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28374069/mu-and-kappa-opioid-receptors-of-the-periaqueductal-gray-stimulate-and-inhibit-thermogenesis-respectively-during-psychological-stress-in-rats
#12
Caroline Cristina-Silva, Victor Martins, Luciane H Gargaglioni, Kênia C Bícego
The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation during psychological stress such as restraint. Because activation of mu and kappa receptors increases and reduces Tb, respectively, we tested the hypothesis that they exert excitatory and inhibitory modulation, respectively, of the restraint-induced fever in rats...
April 4, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28361353/erratum-to-neurobiology-of-local-and-intercellular-bdnf-signaling
#13
Manju Sasi, Beatrice Vignoli, Marco Canossa, Robert Blum
No abstract text is available yet for this article.
March 30, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28357491/acid-sphingomyelinase-ceramide-regulates-carotid-intima-media-thickness-in-simulated-weightless-rats
#14
Yao-Ping Cheng, Hai-Jun Zhang, Yu-Ting Su, Xing-Xing Meng, Xiao-Ping Xie, Yao-Ming Chang, Jun-Xiang Bao
Structural adaptation of arteries to weightlessness might lower the working ability or even threaten the physical health of astronauts, but the underlying mechanism is unclear. Acid sphingomyelinase (ASM) catalyzes ceramide (Cer) generation controlling arterial remodeling through multiple signaling pathways. In the present study, we aimed to investigate the contribution of ASM/Cer to the changes of common carotid artery intima-media thickness (CIMT) induced by simulated weightlessness. Hindlimb-unloaded tail-suspended (HU) rats were used to simulate the effect of weightlessness...
March 29, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28353154/physiome-approach-for-the-analysis-of-vascular-flow-reserve-in-the-heart-and-brain
#15
REVIEW
Kyung Eun Lee, Ah-Jin Ryu, Eun-Seok Shin, Eun Bo Shim
This work reviews the key aspects of coronary and neurovascular flow reserves with an emphasis on physiomic modeling characteristics by the use of a variety of numerical approaches. First, we explain the definition of fractional flow reserve (FFR) in coronary artery and introduce its clinical significance. Then, computational researches for obtaining FFR are reviewed, and their clinical outcomes are compared. In the case of cerebrovascular reserve (CVR), in spite of substantial progress in the simulation of cerebral hemodynamics, only a few computational studies exist...
March 28, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28315005/effect-of-nitric-oxide-on-renal-autoregulation-during-hypothermia-in-the-rat
#16
Lars Mikael Broman, Mattias Carlström, Örjan Källskog, Mats Wolgast
Hypothermia-induced reduction of metabolic rate is accompanied by depression of both glomerular perfusion and filtration. The present study investigated whether these changes are linked to changes in renal autoregulation and nitric oxide (NO) signalling. During hypothermia, renal blood flow (RBF) and glomerular filtration rate (GFR) were reduced and urine production was increased, and this was linked with reduced plasma cGMP levels and increased renal vascular resistance. Although stimulation of NO production decreased vascular resistance, blood pressure and urine flow, intravenous infusion of the NO precursor L-arginine or the NO donor sodium nitroprusside did not alter RBF or GFR...
March 17, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28303387/caveolar-remodeling-is-a-critical-mechanotransduction-mechanism-of-the-stretch-induced-l-type-ca-2-channel-activation-in-vascular-myocytes
#17
Sang Woong Park, Kyung Chul Shin, Hyun Ji Park, Soon-Kyu Yoou, Jin-Yeon Park, Young-Sun Kang, Dong Jun Sung, Jae Gon Kim, Seung Hwa Park, BoKyung Kim, Hana Cho, Young Min Bae
Activation of L-type voltage-dependent Ca(2+) channels (VDCCL) by membrane stretch contributes to many biological responses such as myogenic contraction of arteries. However, mechanism for the stretch-induced VDCCL activation is unclear. In this study, we examined the hypothesis that caveolar remodeling and its related signaling cascade contribute to the stretch-induced activation of VDCCL in rat mesenteric arterial smooth muscle cells. The VDCCL currents were recorded with nystatin-perforated or with conventional whole-cell patch-clamp technique...
March 16, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28299445/immunophysiology-macrophages-as-key-regulators-of-homeostasis-in-various-organs
#18
EDITORIAL
Jonathan Jantsch, Joachim L Schultze, Christian Kurts
No abstract text is available yet for this article.
March 15, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28289977/location-function-and-ontogeny-of-pulmonary-macrophages-during-the-steady-state
#19
REVIEW
Natalio Garbi, Bart N Lambrecht
The lung is continuously exposed to potentially hazardous environmental challenges in the form of inert material and microbes. Pulmonary macrophages are critical in maintaining a low inflammatory context in the lung to facilitate optimal gas exchange. During infection, however, they mediate the immediate response to invading microorganisms in coordination with epithelial cells and other tissue-resident immune cells including dendritic cells, innate lymphocytes and memory T cells, and pulmonary interstitial macrophages...
March 13, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28285409/pharmacological-blockade-of-small-conductance-ca-2-activated-k-channels-by-ica-reduces-arrhythmic-load-in-rats-with-acute-myocardial-infarction
#20
Laura A Hundahl, Stefan M Sattler, Lasse Skibsbye, Jonas G Diness, Jacob Tfelt-Hansen, Thomas Jespersen
Acute myocardial infarction (AMI) with development of ventricular fibrillation (VF) is a common cause of sudden cardiac death (SCD). At present, no pharmacological treatment has successfully been able to prevent VF in the acute stage of AMI. This study investigates the antiarrhythmic effect of inhibiting small conductance Ca(2+)-activated K(+) (SK) channels using the pore blocker N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA) in AMI rats. Acute coronary ligation was performed in 26 anesthetized rats, and ECG, monophasic action potentials (MAPs), and ventricular effective refractory period (vERP) were recorded...
March 11, 2017: Pflügers Archiv: European Journal of Physiology
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