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Phytochemistry

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https://www.readbyqxmd.com/read/28930667/phenylpropanoid-profiling-reveals-a-class-of-hydroxycinnamoyl-glucaric-acid-conjugates-in-isatis-tinctoria-leaves
#1
Thi-Kieu-Oanh Nguyen, Arash Jamali, Eric Grand, Kris Morreel, Paulo Marcelo, Eric Gontier, Rebecca Dauwe
The brassicaceous herb, Isatis tinctoria, is an ancient medicinal plant whose rosette leaf extracts have anti-inflammatory and anti-allergic activity. Brassicaceae are known to accumulate a variety of phenylpropanoids in their rosette leaves acting as antioxidants and a UV-B shield, and these compounds often have pharmacological potential. Nevertheless, knowledge about the phenylpropanoid content of I. tinctoria leaves remains limited to the characterization of a number of flavonoids. In this research, we profiled the methanol extracts of I...
September 17, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28923323/a-unique-indolizinium-alkaloid-streptopertusacin-a-and-bioactive-bafilomycins-from-marine-derived-streptomyces-sp-hzp-2216e
#2
Xiufang Zhang, Lu Chen, Weiyun Chai, Xiao-Yuan Lian, Zhizhen Zhang
Streptopertusacin A, a unique indolizinium alkaloid existing as a zwitterion, and six bafilomycins including two previously undescribed ones of 21,22-en-bafilomycin D and 21,22-en-9-hydroxybafilomycin D were isolated from a culture of the seaweed-derived Streptomyces sp. HZP-2216E. Structures of these isolated compounds were determined based on extensive NMR spectroscopic analyses, HRESIMS and MS-MS data. The stereochemical assignments were achieved by NOE information, chemical degradation, Marfey's method, and electronic circular dichroism (ECD) calculation...
September 15, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28923322/cycloartane-type-triterpene-glycosides-anopanins-a-c-with-monoacyldigalactosylglycerols-from-anodendron-paniculatum
#3
Viet Duc Ho, Thi Nhu Hanh Hoang, Quoc Hung Vo, Van Kiem Phan, Tuan Anh Le, Viet Ty Pham, Minh Hien Nguyen, Takeshi Kodama, Takuya Ito, Hiroyuki Morita, Ain Raal, Thi Hoai Nguyen
Three cycloartane-type triterpene glycosides (anopanins A-C), together with three known monoacyldigalactosylglycerols gingerglycolipids A-C and (2S)-1-O-palmitoyl-3-O-[α-d-galactopyranosyl-(1→6)-β-d-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma)...
September 15, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28917090/oleanane-triterpenes-with-protein-tyrosine-phosphatase-1b-inhibitory-activity-from-aerial-parts-of-lantana-camara-collected-in-indonesia-and-japan
#4
Delfly B Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Henki Rotinsulu, Defny S Wewengkang, Deiske A Sumilat, Magie M Kapojos, Fitje Losung, Kazuyo Ukai, Michio Namikoshi
During the search for new protein tyrosine phosphatase (PTP) 1B inhibitors, EtOH extracts from the aerial parts of Lantana camara L. (lantana) collected at Manado (Indonesia) and two subtropical islands in Japan (Ishigaki and Iriomote Islands, Okinawa) exhibited potent inhibitory activities against PTP1B in an enzyme assay. Four previously undescribed oleanane triterpenes were isolated together with known triterpenes and flavones from the Indonesian lantana. The EtOH extracts of lantana collected in Ishigaki and Iriomote Islands exhibited different phytochemical profiles from each other and the Indonesian lantana...
September 13, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28911879/corrigendum-to-biosynthesis-and-chemical-transformation-of-benzoxazinoids-in-rye-during-seed-germination-and-the-identification-of-a-rye-bx6-like-gene-phytochemistry-140-2017-95-107
#5
Fariha Tanwir, Giuseppe Dionisio, Khem B Adhikari, Inge S Fomsgaard, Per L Gregersen
No abstract text is available yet for this article.
September 11, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28910607/molecular-cloning-and-functional-expression-of-lewis-type-%C3%AE-1-3-%C3%AE-1-4-fucosyltransferase-cdnas-from-mangifera-indica-l
#6
Takahiro Okada, Hideyuki Ihara, Ritsu Ito, Yoshitaka Ikeda
In higher plants, complex type N-glycans contain characteristic carbohydrate moieties that are not found in mammals. In particular, the attachment of the Lewis a (Le(a)) epitope is currently the only known outer chain elongation that is present in plant N-glycans. Such a modification is of great interest in terms of the biological function of complex type N-glycans in plant species. However, little is known regarding the exact molecular basis underlying their Le(a) expression. In the present study, we cloned two novel Lewis type fucosyltransferases (MiFUT13) from mango fruit, Mangifera indica L...
September 11, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28910606/multivariate-analysis-as-a-key-tool-in-chemotaxonomy-of-brinjal-eggplant-african-eggplants-and-wild-related-species
#7
Łukasz P Haliński, John Samuels, Piotr Stepnowski
The brinjal eggplant (Solanum melongena L.) is an important vegetable species worldwide, while African eggplants (S. aethiopicum L., S. macrocarpon L.) are indigenous vegetable species of local significance. Taxonomy of eggplants and their wild relatives is complicated and still unclear. Hence, the objective of the study was to clarify taxonomic position of cultivars and landraces of brinjal, its wild relatives and African eggplant species and their wild ancestors using chemotaxonomic markers and multivariate analysis techniques for data processing, with special attention paid to the recognition of markers characteristic for each group of the plants...
September 11, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28898741/comparative-studies-of-cutins-from-lime-citrus-aurantifolia-and-grapefruit-citrus-paradisi-after-tfa-hydrolysis
#8
Brenda Liliana Hernández Velasco, Daniel Arrieta-Baez, Pedro Iván Cortez Sotelo, Juan Vicente Méndez-Méndez, Blanca Margarita Berdeja Martínez, Mayra Beatriz Gómez-Patiño
Grapefruit and lime cutins were analyzed and compared in order to obtain information about their cutin architecture. This was performed using a sequential hydrolysis, first with trifluoroacetic acid to remove most of the polysaccharides present in the cutins, followed by an alkaline hydrolysis in order to obtain the main aliphatic compounds. Analysis by CPMAS (13)C NMR and ATR FT-IR of the cutins after 2.0 M TFA revealed that grapefruit cutin has independent aliphatic and polysaccharide domains while in the lime cutin these components could be homogeneously distributed...
September 9, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28892660/phytotoxic-triterpene-saponins-from-bellis-longifolia-an-endemic-plant-of-crete
#9
Maria I Stavropoulou, Apostolis Angelis, Nektarios Aligiannis, Eleftherios Kalpoutzakis, Sofia Mitakou, Stephen O Duke, Nikolas Fokialakis
In a study of 62 plant species of the Cretan flora for their phytotoxic activity, plants were extracted successively with CH2Cl2, MeOH and H2O. Phytotoxicity evaluation of the 240 extracts was performed against Lactuca sativa L. and Agrostis stolonifera L.. The MeOH extract of Bellis longifolia was the most phytotoxic. Bioassay-guided fractionation revealed that a fraction consisting mainly of saponins was the most effective. Separation of the saponins was performed using initially a step-gradient Centrifugal Partition Chromatography (CPC)...
September 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28888783/phytochemical-study-of-juglans-regia-l-leaves
#10
Sebastian Schwindl, Birgit Kraus, Jörg Heilmann
A methanolic extract of Juglans regia L. leaves was fractioned by various chromatographic techniques yielding a total of 40 metabolites belonging to megastigmane, tetralone, phenylpropanoid, neolignane and juglone glycosides. Ten unknown megastigmane glucoside derivatives (juglanionosides A-K, 1-10) and six unknown tetralone glucoside derivatives (juglanosides J-O, 11-16) together with 24 known compounds - among them 16 described for the first time in Juglans - were isolated. As characteristic structural feature, the previously undescribed compounds showed acylation of the sugar units with sinapic, ferulic, coumaric, benzoic or salicylic acid...
September 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28888145/nmr-based-identification-of-the-major-bioactive-molecules-from-an-italian-cultivar-of-lycium-barbarum
#11
Annalisa Lopatriello, Rosario Previtera, Simona Pace, Markus Werner, Luigi Rubino, Oliver Werz, Orazio Taglialatela-Scafati, Martino Forino
Lycium barbarum (Solanaceae), long known to the traditional Chinese medicine because of its many health-promoting effects, has of late spread widely across the Western hemisphere, mainly on account of the nutritional richness in vitamins, minerals and antioxidant metabolites of its fruits. Data on bioactive metabolites from fruits and leaves, which are commonly consumed in soups and salads, are scarce and sometimes even contradictory. By means of NMR, the present study identified the specialised products contained in an Italian cultivar of L...
September 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28888144/previously-undescribed-fridooleanenes-and-oxygenated-labdanes-from-the-brown-seaweed-sargassum-wightii-and-their-protein-tyrosine-phosphatase-1b-inhibitory-activity
#12
Anusree Maneesh, Kajal Chakraborty
Previously undescribed fridooleanene triterpenoids 2α-hydroxy-(28,29)-frido-olean-12(13), 21(22)-dien-20-propyl-21-hex-4'(Z)-enoate, 2α-hydroxy-(28,29)-frido-olean-12(13), 21(22)-dien-20-prop-2(E)-en-21-butanoate and oxygenated labdane diterpenoids 2α-hydroxy-8(17), (12E), 14-labdatriene, 3β, 6β, 13α-tri hydroxy 8(17), 12E, 14-labdatriene were purified from the ethyl acetate-methanol and dichloromethane fractions of the air-dried thalli of Sargassum wightii (Sargassaceae), a brown seaweed collected from the Gulf-of-Mannar of Penninsular India...
September 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28881198/ecophysiological-strategies-for-growth-under-varying-light-and-organic-carbon-supply-in-two-species-of-green-microalgae-differing-in-their-motility
#13
Elly Spijkerman, Marcus Lukas, Alexander Wacker
Mixing events in stratified lakes result in microalgae being exposed to varying conditions in light and organic carbon concentrations. Stratified lakes consist of an upper illuminated strata and a lower, darker strata where organic carbon accumulates. Therefore, in this contribution we explore the importance of dissolved organic carbon for growth under various light intensities by measuring some ecophysiological adaptations in two green microalgae. We compared the non-motile Chlorella vulgaris with the flagellated Chlamydomonas acidophila under auto-, mixo-, and heterotrophic growth conditions...
September 4, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28881197/oleanane-type-triterpene-saponins-from-calendula-stellata
#14
Meryem Lehbili, Abdulmagid Alabdul Magid, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Amin Abedini, Hamid Morjani, Thomas Sarazin, Sophie C Gangloff, Zahia Kabouche
Five previously undescribed bisdesmosidic triterpenoid saponins named calendustellatosides A-E, along with fifteen known compounds were isolated from the 70% ethanol whole plant extract of Calendula stellata Cav. (Asteraceae). Their structures were determined by 1D- and 2D-NMR spectroscopy as well as high resolution mass spectrometry and acid hydrolysis. The saponins comprised oleanolic acid, echinocystic acid, morolic acid or mesembryanthemoidigenic acid as the aglycones and saccharide moieties at C-3 and C-28...
September 4, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28869908/bioactive-ent-kaurane-diterpenoids-from-isodon-rubescens
#15
Yuan-Yuan Zhang, Hua-Yi Jiang, Miao Liu, Kun Hu, Wei-Guang Wang, Xue Du, Xiao-Nian Li, Jian-Xin Pu, Han-Dong Sun
Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC50 values ranging from 0...
September 1, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28863306/the-study-of-flavonolignan-association-patterns-in-fruits-of-diverging-silybum-marianum-l-gaertn-chemotypes-provides-new-insights-into-the-silymarin-biosynthetic-pathway
#16
Tommaso Martinelli, Anne Whittaker, Stefano Benedettelli, Andrea Carboni, Jadwiga Andrzejewska
Silymarin is the phytochemical with medicinal properties extracted from Silybum marianum (L.) Gaertn. fruits. Yet, little information is available about silymarin biosynthesis. Moreover, the generally accepted pathway, formulated thus far, is not in agreement with actual experimental measurements on flavonolignan contents. The present work analyses flavonolignan and taxifolin content in 201 S. marianum samples taking into consideration a wide phenotypic variability. Two stable chemotypes were identified: one characterized by both high silychristin and silybin content (chemotype A) and another by a high silydianin content (chemotype B)...
August 29, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28863305/diterpenoids-from-the-roots-of-croton-dichogamus-pax
#17
Areej Aldhaher, Moses Langat, Beth Ndunda, Denis Chirchir, Jacob O Midiwo, Alice Njue, Sianne Schwikkard, Mark Carew, Dulcie Mulholland
Four previously undescribed diterpenoids including two crotofolanes, crotodichogamoin A and B, and two halimanes, crothalimene A and B, a new sesquiterpenoid, and fifteen previously reported compounds, including the crotofolane, crotohaumanoxide, the casbane, depressin, a further seven furanohalimane diterpenoids, three patchoulane and two further cadinane sesquiterpenoids and aleuritolic acid were isolated from the root of Croton dichogamus. Crotodichogamoin B is an important biosynthetic intermediate of the crotofolane class and this is the first report of patchoulene sesquiterpenoids from the genus...
August 28, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28843162/antiproliferative-metabolites-from-the-northern-african-endemic-plant-daucus-virgatus-apiaceae
#18
Alì Snene, Carmina Sirignano, Daniela Rigano, Carmen Formisano, Ridha El Mokni, Giuseppe Ercolano, Hatem Dhaouadi, Angela Ianaro, Saoussen Hammami, Orazio Taglialatela-Scafati
Chemical analysis of the dichloromethane fraction obtained from aerial parts of the Northern African endemic plant Daucus virgatus led to the isolation of three previously undescribed sesquiterpenoids, namely the daucane vaginatin B, a eudesmane and the elemane elemavirgolide, along with five known metabolites. The structures of these compounds were determined by a detailed MS and NMR analysis and they were evaluated for antiproliferative activity against three human cell lines, A375 (melanoma), MCF-7 (breast adenocarcinoma), and HACAT (keratinocyte)...
August 23, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28825980/isoflavones-and-anti-inflammatory-constituents-from-the-fruits-of%C3%A2-psoralea-corylifolia
#19
Chiang-Hsiang Chen, Tsong-Long Hwang, Li-Chai Chen, Tsung-Hsien Chang, Chun-Sheng Wei, Jih-Jung Chen
The fruits of Psoralea corylifolia, known as Psoraleae Fructus (Buguzhi in Chinese), are traditionally used for the treatment of spermatorrhea, nephritis, asthma, pollakiuria, and various inflammatory diseases. Three previously undescribed isoflavone derivatives, 7-O-methylcorylifol A, 7-O-isoprenylcorylifol A, and 7-O-isoprenylneobavaisoflavone, have been isolated from the fruits of P. corylifolia, together with 9 known compounds. The structures of these compounds were determined through spectroscopic and MS analyses...
August 18, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28822320/bio-active-maneonenes-and-isomaneonene-from-the-red-alga-laurencia-obtusa
#20
Nahed O Bawakid, Walied M Alarif, Ali I Ismail, Mohamed E El-Hefnawy, Khalid O Al-Footy, Sultan S Al-Lihaibi
Three previously undescribed compounds, maneonenes and isomaneonene derivatives; in addition to five known compounds, two cuparene, one chamigrene, and two cis-maneonenes were isolated from the Red Sea red alga Laurencia obtusa. The chemical structures of all unknown metabolites were characterized employing spectroscopic methods and then were further confirmed by single crystal X-ray analysis. Jeddahenyne A has C-5-C-12 etheric linkage and C-13-C-14 carbon-carbon double bond; Jeddahenyne B has in addition to the aforementioned etheric linkage a C-13 carbonyl function and absence of halogenation, unusual features for the maneonenes while 12-debromo-12-methoxy isomaneonene A shows unrecorded methoxylation at C-12...
August 16, 2017: Phytochemistry
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