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Journal of Antibiotics

Kazuki Ishikawa, Kazunori Takahashi, Syun Hosoi, Hisashi Takeda, Hinaka Yoshida, Daigo Wakana, Masayoshi Tsubuki, Fumihiko Sato, Motoaki Tojo, Tomoo Hosoe
Coptidis rhizome (CR) is a widely used herbal medicine that contains protoberberine-type alkaloids. CR extract exhibits various pharmacologic activities. A previous study reported the isolation of Rhodococcus sp. strain BD7100 as a berberine (BBR)-utilizing bacterium, and the BBR-degradation pathway has been investigated. When we incubated strain BD7100 cells with CR extract, the number of viable cells declined with the degradation of components in the CR extract, and the culture broth exhibited antibacterial activity against strain BD7100...
November 9, 2018: Journal of Antibiotics
Supattra Muangham, Kenika Lipun, Atsuko Matsumoto, Yuki Inahashi, Kannika Duangmal
A novel endophytic actinobacterium, designated strain RL12-1ST , was isolated from surface-sterilized leaves of Oryza sativa L. collected from Roi Et province, Thailand. Taxonomic position of strain RL12-1ST was studied using the polyphasic approach. Phylogenetic analyses base on the 16S rRNA gene sequences showed that strain RL12-1ST belonged to the genus Quadrisphaera and was closely related to Quadrisphaera granulorum AG019T (99.0%). The colony of strain RL12-1ST was vivid orange. Growth occurred at a temperature between 17-37 °C and pH between 6...
November 2, 2018: Journal of Antibiotics
Wei-He Liu, Yi Ding, Xiang Ji, Fa-Liang An, Yan-Hua Lu
Curvulaide A (1), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A (1) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62...
October 26, 2018: Journal of Antibiotics
Hayami Kudo, Masaru Usui, Wataru Nagafuji, Kentaro Oka, Motomichi Takahashi, Hiroyuki Yamaguchi, Yutaka Tamura
Flavophospholipol (FPL) is an antimicrobial feed additive that has been approved for use in livestock animals and has the potential to decrease horizontal dissemination of antimicrobial resistance genes. Since previous studies showed that FPL has an inhibitory effect on plasmid transfer, in vitro experiments have proven the efficacy of FPL in reducing the conjugative transfer of plasmids encoding the extended-spectrum β-lactamase (ESBL) and vanA genes. These are among the most important antimicrobial resistance loci known...
October 25, 2018: Journal of Antibiotics
Priyanka Surwade, Christopher Ghildyal, Chase Weikel, Todd Luxton, Derek Peloquin, Xin Fan, Vishal Shah
At present, including failed attempts, it takes about 15 years and costs totaling up to $2.6 billion to take a promising new compound from laboratory to the market. Increasing drug resistance among microbial pathogens has led to a growing interest in exploring novel methods to enhance the efficacy of existing drugs. Combination therapies involving two or more known antimicrobial methods, particularly those involving nanoparticles for combating the clinical problems associated with antibiotic resistance, have been garnering interest...
October 25, 2018: Journal of Antibiotics
Appadurai Muthamil Iniyan, Enge Sudarman, Joachim Wink, Rajaretinam Rajesh Kannan, Samuel Gnana Prakash Vincent
Bioassay-guided screening of antibacterial compounds from the cultured marine Streptomyces sp. ICN19 provided Ala-geninthiocin (1), along with its known analogs geninthiocin (2) and Val-geninthiocin (3) and the indolocarbazole staurosporine (4). The structure of 1 was determined on the basis of 1D and 2D NMR spectra and ESI-HRMS. The absolute configurations of the amino acid residues were determined by enantioselective GC-MS analysis. Compound 1 exhibited potent activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, Mycobacterium smegmatis, and Micrococcus luteus, as well as cytotoxicity against A549 human lung carcinoma cells with an IC50 value of 6 nM...
October 24, 2018: Journal of Antibiotics
Nobuhiro Koyama, Hiroshi Tomoda
No abstract text is available yet for this article.
October 23, 2018: Journal of Antibiotics
Rong-Wei Kou, Shuang-Tian Du, Yi-Xiao Li, Xi-Tao Yan, Qiang Zhang, Chen-Yu Cao, Xia Yin, Jin-Ming Gao
Five terpenoids, including two new cyathane diterpenoids neocyathin S (1) and neocyathin T (2), together with three drimane sesquiterpenoids, one known 3β,6β-dihydroxycinnamolide (3), two new ones 3β,6α-dihydroxycinnamolide (4) and 2-keto-3β,6β-dihydroxycinnamolide (5), were isolated from the cultures of the basidiomycete Cyathus africanus. Their structures were established based on extensive spectroscopic methods including 2D NMR (HSQC, 1 H‒1 H-COSY, HMBC, ROESY) and HRESIMS experiments. The absolute configurations of two pairs of epimers, 1 and 2 as well as 3 and 4, were determined by ECD quantum chemical calculation...
October 16, 2018: Journal of Antibiotics
Anna N Tevyashova, Alexander M Korolev, Elena P Mirchink, Elena B Isakova, Ilya A Osterman
Novel benzoxaborole derivatives of azithromycin in which benzoxaborole residue is attached to the 4″-hydroxy-group of azithromycin have been synthesized. Antibacterial activity of synthesized derivatives in comparison with azithromycin was tested on a panel of Gram-positive and Gram-negative bacterial strains. All the investigated compounds demonstrated broad spectrum of antibacterial activity being in general more active against Gram-positive strains. New benzoxaborole derivatives of azithromycin demonstrated high activity against Streptococcus pyogenes ATCC 19615 and Propionibacterium acnes ATCC 6919 strains...
October 12, 2018: Journal of Antibiotics
Issara Kaweewan, Hisayuki Komaki, Hikaru Hemmi, Kanata Hoshino, Takeshi Hosaka, Gouchi Isokawa, Takanori Oyoshi, Shinya Kodani
Using genome mining, a new cytotoxic peptide named curacozole was isolated from Streptomyces curacoi. Through ESI-MS and NMR analyses, curacozole was determined to be a macrocyclic peptide containing two isoleucine, two thiazole and three oxazole moieties. Curacozole exhibited potent cytotoxic activity against HCT116 and HOS cancer cells. The proposed biosynthetic gene cluster of curacozole was identified and compared with that of the related compound YM-216391.
October 11, 2018: Journal of Antibiotics
Takashi Fukuda, Takun Furukawa, Keisuke Kobayashi, Kenichiro Nagai, Ryuji Uchida, Hiroshi Tomoda
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the fungus Aspergillus nidulans BF-0142 along with a known helvafuranone (3). The structures of 1 and 2 were elucidated based on spectroscopic analyses by the interpretation of one-dimensional and two-dimensional nuclear magnetic resonance data, ROESY (rotational Overhauser effect spectroscopy) correlations, and a chemical method. Helvamide existed as a rotameric mixture (1 and 2) in dimethyl sulfoxide...
October 10, 2018: Journal of Antibiotics
Li Chen, Ya-Ping Li, Xin-Xin Li, Zhi-Hao Lu, Qiu-Hong Zheng, Qin-Ying Liu
4,4'-bond secalonic acid D (4,4'-SAD) is a known compound isolated from the marine-derived fungus Penicillium oxalicum. No study about the antitumor effect of this compound has been reported, except for a few focusing on its bactericidal properties. Herein, we performed an in vitro biology test and found that 4,4'-SAD stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines PLC/PRF/5 and HuH-7 by activating caspase-3, caspase-8, caspase-9, PARP, p53, and cyclin B1, as well as by regulating the Bax/Bcl-2 ratio...
September 27, 2018: Journal of Antibiotics
Ziwen Cong, Xiaolong Huang, Yunhao Liu, Yuxuan Liu, Pei Wang, Shengrong Liao, Bin Yang, Xuefeng Zhou, Dongyi Huang, Junfeng Wang
Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11...
September 26, 2018: Journal of Antibiotics
Hao Su, Li Han, Xueshi Huang
In recent years, incidences of invasive fungal infections have greatly increased, especially in immunosuppressed patients, but most today's antifungal drugs are not completely effective due to the development of drug resistance, as well as potential toxicity and adverse effects. Consequently, it is imperative to search for novel antifungal agents to combat fungal infections. This review will discuss the advances in the traditional antifungal therapy, and present an overview of novel strategies for the treatment of fungal infections...
September 21, 2018: Journal of Antibiotics
Katsuyuki Sakai, Takuya Suga, Masato Iwatsuki, Takumi Chinen, Kenichi Nonaka, Takeo Usui, Yukihiro Asami, Satoshi Ōmura, Kazuro Shiomi
Secondary metabolites of microorganisms have proven to be an excellent source of drugs. We isolated a new antibiotic, named pestiocandin (1), from a culture broth of a filamentous fungus, Pestalotiopsis humus FKI-7473, using a multidrug-sensitive budding yeast, S. cerevisiae 12geneΔ0HSR-iERG6. The structure of 1 was elucidated by various NMR studies. All geometric isomerisms of 1 were shown to be the E-form and two pyranose units of 1 were found to be glucose and galactose types. Compound 1 showed weak growth inhibition against Gram-positive and Gram-negative bacteria, yeasts and a filamentous fungus...
September 19, 2018: Journal of Antibiotics
Feng-Xian Yang, Guan-Xiong Hou, Jianying Luo, Jing Yang, Yijun Yan, Sheng-Xiong Huang
Chemical investigation of a strain Streptomyces sp. KIB-H1318 isolated from soil sample led to the discovery of three new phenoxazinone-related alkaloids 1-3, as well as two known analogs exfoliazone (4) and viridobrunnine A (5). Their structures were determined on the basis of extensive spectroscopic analysis. The antimicrobial activity and cytotoxicity of the isolates were assayed. Exfoliazone and viridobrunnine A exhibited minor antibacterial activity against Escherichia coli ATCC 8099, Bacillus subtilis ATCC 6633, and Staphylococcus aureus ATCC 6538...
September 14, 2018: Journal of Antibiotics
Nourhan Hisham Shady, Mostafa A Fouad, Safwat Ahmed, Sheila Marie Pimentel-Elardo, Justin R Nodwell, Mohamed Salah Kamel, Usama Ramadan Abdelmohsen
The antitrypanosomally active crude extract of the sponge Hyrtios sp. was subjected to metabolomic analysis using liquid chromatography coupled with high resolution electrospray ionization mass spectrometry (LC-HR-ESIMS) for dereplication purposes. As a result, a new alkaloid, hyrtiodoline A (1), along with other four known compounds (2-5) were reported. The structures of compounds 1-5 were determined by spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESI-MS) experiments, as well as comparison to the literature...
September 4, 2018: Journal of Antibiotics
Taichi Ohshiro, Reiko Seki, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda
New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307. The structures of celludinones were elucidated by spectroscopic data, including 1D and 2D NMR. Celludinone A was found to be a mixture of racemic isomers ((±)-1), which were isolated by a chiral column. Compounds (+)-1 and (-)-1 inhibited the sterol O-acyltransferase (SOAT) 1 and 2 isozymes in a cell-based assay using SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells, while 2 selectively inhibited the SOAT2 isozyme...
September 3, 2018: Journal of Antibiotics
Jie Bao, Fei He, Yumei Li, Lei Fang, Kaiming Wang, Jintong Song, Jie Zhou, Qiang Li, Hua Zhang
Three new angucycline-type C-glycosides, grincamycins L-N (1-3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1-3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1-9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus...
August 29, 2018: Journal of Antibiotics
Kazuki Ujiie, Hideyuki Matsuura, Tran Thi My Duyen, Koki Izutsu, Ayaka Nitta, Kazuo Harada, Kazumasa Hirata
Sulfonamide residue in foodstuffs and the environment is a serious global concern for their contribution to the occurrence of antibiotic-resistant bacteria, especially in developing countries. Here, we describe a novel, simple, and low-cost bioassay for sulfonamides, which has high potential versatility for use in low-resource settings. The bioassay method is based on a purpose-built luminescent assay reaction that detects sulfonamide groups. The luminescent assay reaction comprises dihydropteroate synthase, a target enzyme of sulfonamides, and luminescent pyrophosphate detection reagent, which triggers a sequence of biomolecular reactions that convert sulfonamides to emit luminescence...
August 23, 2018: Journal of Antibiotics
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