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Journal of Antibiotics

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https://www.readbyqxmd.com/read/27899793/bacterial-proteases-untapped-antimicrobial-drug-targets
#1
REVIEW
Elizabeth Culp, Gerard D Wright
Bacterial proteases are an extensive collection of enzymes that have vital roles in cell viability, stress response and pathogenicity. Although their perturbation clearly offers the potential for antimicrobial drug development, both as traditional antibiotics and anti-virulence drugs, they are not yet the target of any clinically used therapeutics. Here we describe the potential for and recent progress in the development of compounds targeting bacterial proteases with a focus on AAA+ family proteolytic complexes and signal peptidases (SPs)...
November 30, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27899792/nature-nurtures-the-design-of-new-semi-synthetic-macrolide-antibiotics
#2
REVIEW
Prabhavathi Fernandes, Evan Martens, David Pereira
Erythromycin and its analogs are used to treat respiratory tract and other infections. The broad use of these antibiotics during the last 5 decades has led to resistance that can range from 20% to over 70% in certain parts of the world. Efforts to find macrolides that were active against macrolide-resistant strains led to the development of erythromycin analogs with alkyl-aryl side chains that mimicked the sugar side chain of 16-membered macrolides, such as tylosin. Further modifications were made to improve the potency of these molecules by removal of the cladinose sugar to obtain a smaller molecule, a modification that was learned from an older macrolide, pikromycin...
November 30, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27899791/quinoline-and-naphthalene-derivatives-from-saccharopolyspora-sp-yim-m13568
#3
Mingwei Sun, Jinhuan Ou, Wenjun Li, Chunhua Lu
No abstract text is available yet for this article.
November 30, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27899790/revisiting-unexploited-antibiotics-in-search-of-new-antibacterial-drug-candidates-the-case-of-msd-819-6-chloro-2-quinoxalinecarboxylic-acid-1-4-dioxide
#4
Nicola Ooi, Alex J O'Neill
No abstract text is available yet for this article.
November 30, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27876750/8-epimer-of-herbicidin-f-and-its-congeners-from-streptomyces-sp-yim-66142
#5
Ju-Cheng Zhang, Ya-Bin Yang, Guang-Yi Chen, Xiao-Zhan Li, Ming Hu, Bang-Yan Wang, Bao-Hui Ruan, Hao Zhou, Li-Xing Zhao, Zhong-Tao Ding
No abstract text is available yet for this article.
November 23, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27876749/anti-fungal-activity-of-ctn-15-34-the-c-terminal-peptide-fragment-of-crotalicidin-a-rattlesnake-venom-gland-cathelicidin
#6
Carolina Sidrim P Cavalcante, Cláudio B Falcão, Raquel Os Fontenelle, David Andreu, Gandhi Rádis-Baptista
Crotalicidin (Ctn), a 34-residue cathelicidin from a South American rattlesnake, and its fragment (Ctn[15-34]) have shown anti-infective and cytotoxic activities against Gram-negative bacteria and certain tumor lines, respectively. The extent of such effects has been related to physicochemical characteristics such as helicity and hydrophobicity. We now report the anti-fungal activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]). MIC determination and luminescent cell viability assays were used to evaluate the anti-infective activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]) as anti-fungal agents against opportunistic yeast and dermatophytes...
November 23, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27847387/bio-based-production-of-fuels-and-industrial-chemicals-by-repurposing-antibiotic-producing-type-i-modular-polyketide-synthases-opportunities-and-challenges
#7
REVIEW
Satoshi Yuzawa, Jay D Keasling, Leonard Katz
Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals...
November 16, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27826144/screening-of-nci-dtp-library-to-identify-new-drug-candidates-for-borrelia-burgdorferi
#8
Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, R Edward Watts, Kwang-Min Kim, Mansi B Parekh, Abhijit Achyut Gurjarpadhye, David Solow-Cordero, Lobat Tayebi, Jayakumar Rajadas
No abstract text is available yet for this article.
November 9, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27804952/re-identification-of-the-ascofuranone-producing-fungus-ascochyta-viciae-as-acremonium-sclerotigenum
#9
Yasuaki Hijikawa, Motomichi Matsuzaki, Shigeo Suzuki, Daniel Ken Inaoka, Ryoko Tatsumi, Yasutoshi Kido, Kiyoshi Kita
No abstract text is available yet for this article.
November 2, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27804951/a-new-cytotoxic-and-anti-fungal-c-glycosylated-benz-%C3%AE-anthraquinone-from-the-broth-of-endophytic-streptomyces-blastomycetica-strain-f4-20
#10
He Yan, Yang Li, Xing Y Zhang, Wan Y Zhou, Tao J Feng
No abstract text is available yet for this article.
November 2, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27780966/isolation-and-identification-of-new-macrocyclic-lactones-from-a-genetically-engineered-strain-streptomyces-bingchenggensis-bcj60
#11
Jiansong Li, Shaoyong Zhang, Hui Zhang, Haiyan Wang, Ji Zhang, Anliang Chen, Jidong Wang, Wensheng Xiang
No abstract text is available yet for this article.
October 26, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27756913/antibiotics-in-microbial-coculture
#12
Kenji Ueda, Teruhiko Beppu
Today, the frequency of discovery of new antibiotics in microbial culture is significantly decreasing. The evidence from whole-genome surveys suggests that many genes involved in the synthesis of unknown metabolites do exist but are not expressed under conventional cultivation conditions. Therefore, it is urgently necessary to study the conditions that make otherwise silent genes active in microbes. Here we overview the knowledge on the antibiotic production promoted by cocultivation of multiple microbial strains...
October 19, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27756912/microbacterium-lacusdiani-sp-nov-a-phosphate-solubilizing-novel-actinobacterium-isolated-from-mucilaginous-sheath-of-microcystis
#13
Bing-Huo Zhang, Nimaichand Salam, Juan Cheng, Han-Quan Li, Jian-Yuan Yang, Dai-Ming Zha, Qi-Gen Guo, Wen-Jun Li
A novel actinobacterium, designated strain JXJ CY 01(T), was isolated from a mucilaginous sheath of Microcystis aeruginosa FACHB-905 collected from Lake Dianchi, south-west China. Taxonomic position of the isolate was determined by polyphasic approaches. Strain JXJ CY 01(T) shared 16S rRNA sequence similarities of 98.9 and 98.0% with Microbacterium marinilacus YM11-607(T) and Microbacterium paludicola US15(T), and less than 98% with other members of the genus Microbacterium. The DNA-DNA relatedness values between strains JXJ CY 01(T) and M...
October 19, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27756911/antiviral-effect-of-theaflavins-against-caliciviruses
#14
Mai Ohba, Tomoichiro Oka, Takayuki Ando, Saori Arahata, Asaka Ikegaya, Hirotaka Takagi, Naohisa Ogo, Chelsea Zhu, Kazuhiro Owada, Fumihiko Kawamori, Qiuhong Wang, Linda J Saif, Akira Asai
Caliciviruses are contagious pathogens of humans and various animals. They are the most common cause of viral gastroenteritis in humans, and can cause lethal diseases in domestic animals such as cats, rabbits and immunocompromised mice. In this study, we conducted cytopathic effect-based screening of 2080 selected compounds from our in-house library to find antiviral compounds against three culturable caliciviruses: feline calicivirus, murine norovirus (MNV) and porcine sapovirus (PoSaV). We identified active six compounds, of which two compounds, both related to theaflavins, showed broad antiviral activities against all three caliciviruses; three compounds (abamectin, a mixture of avermectin B1a and B1b; avermectin B1a; and (-)-epigallocatechin gallate hydrate) were effective against PoSaV only; and a heterocyclic carboxamide derivative (BFTC) specifically inhibited MNV infectivity in cell cultures...
October 19, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27756910/validation-of-the-mutant-selection-window-hypothesis-with-fosfomycin-against-escherichia-coli-and-pseudomonas-aeruginosa-an-in-vitro-and-in-vivo-comparative-study
#15
Ai-Jun Pan, Qing Mei, Ying Ye, Hong-Ru Li, Bao Liu, Jia-Bin Li
The purpose of this study was to validate the mutant selection window (MSW) hypothesis in vitro and in vivo with Escherichia coli and Pseudomonas aeruginosa exposed to fosfomycin. Two standard strains of Gram-negative bacteria, those are E. coli ATCC 25922 and P. aeruginosa ATCC 27853, were exposed to fosfomycin at concentrations below MIC, between the MIC and the mutant prevention concentration (MPC), and above the MPC in Luria-Bertani broth and in a tissue-cage infection model, respectively. With the in vitro time-kill studies, there were bacterial re-growth and emergence of resistance thereafter for both strains at antibiotic concentrations of × 4, × 8 and × 16 MIC...
October 19, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27731337/production-of-valuable-compounds-by-molds-and-yeasts
#16
Arnold L Demain, Evan Martens
We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among microbial biochemists. He began his professional career as an organic chemistry PhD student at Nottingham University, moved on to a postdoctoral fellowship at Columbia University, then became a lecturer at the University of Manchester, followed by a fellowship in microbial biochemistry at Harvard Medical School. In 1965, he studied genetics at the Pasteur Institute, and 2 years later joined the University of Wisconsin in the Department of Biochemistry...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27731336/characterization-of-the-biosynthetic-gene-cluster-ata-for-the-a201a-aminonucleoside-antibiotic-from-saccharothrix-mutabilis-subsp-capreolus
#17
Irene Saugar, Brian Molloy, Eloisa Sanz, María Blanca Sánchez, María Fernández-Lobato, Antonio Jiménez
Antibiotic A201A produced by Saccharothrix mutabilis subsp. capreolus NRRL3817 contains an aminonucleoside (N(6), N(6)-dimethyl-3'-amino-3'-deoxyadenosyl), a polyketide (α-methyl-p-coumaric acid) and a disaccharide moiety. The heterologous expression in Streptomyces lividans and Streptomyces coelicolor of a S. mutabilis genomic region of ~34 kb results in the production of A201A, which was identified by microbiological, biochemical and physicochemical approaches, and indicating that this region may contain the entire A201A biosynthetic gene cluster (ata)...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27731335/amide-compound-synthesis-by-adenylation-domain-of-bacillibactin-synthetase
#18
Tomoko Abe, Yoshiteru Hashimoto, Sayaka Sugimoto, Kenta Kobayashi, Takuto Kumano, Michihiko Kobayashi
The adenylation domain of nonribosomal peptide synthetase (NRPS) is responsible for the selective substrate recognition and its activation (as an acyl-O-AMP intermediate) during ATP consumption. DhbE, a stand-alone adenylation domain, acts on an aromatic acid, 2,3-dihydroxybenzoic acid (DHB). This activation is the initial step of the synthesis of bacillibactin that is a high-affinity small-molecule iron chelator also termed siderophore. Subsequently, the activated DHB is transferred and attached covalently to a peptidyl carrier protein domain via a thioester bond...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27731334/julian-davies-and-the-discovery-of-kanamycin-resistance-transposon-tn5
#19
Douglas E Berg
This paper recounts some of my fond memories of a collaboration between Julian Davies and myself that started in 1974 in Geneva and that led to our serendipitous discovery of the bacterial kanamycin resistance transposon Tn5, and aspects of the lasting positive impact of our interaction and discovery on me and the community. Tn5 was one of the first antibiotic resistance transposons to be found. Its analysis over the ensuing decades provided valuable insights into mechanisms and control of transposition, and led to its use as a much-valued tool in diverse areas of molecular genetics, as also will be discussed here...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27731333/new-isofuranonaphthoquinones-and-isoindolequinones-from-streptomyces-sp-cb01883
#20
Zhikai Guo, Guohui Pan, Zhengren Xu, Dong Yang, Hindra, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Ben Shen
Isofuranonaphthoquinones (IFQs) and Isoindolequinones (IIQs) comprise a small family of natural products, with the latter ones are especially uncommon in nature. Here we report the discovery of seven new IFQs, IFQ A-G (1-7), and three new IIQs, IIQ A-C (8-10), along with the known anthraquinone desoxyerythrolaccin (11), from Streptomyces sp. CB01883, expanding the chemical diversity of this family of natural products. The structures of these natural products were established on the basis of their HR-ESI-MS and nuclear magnetic resonance (NMR) spectroscopic data...
October 12, 2016: Journal of Antibiotics
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