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Journal of Antibiotics

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https://www.readbyqxmd.com/read/28196980/competition-and-co-regulation-of-spirotoamide-and-tautomycetin-biosynthesis-in-streptomyces-griseochromogenes-and-isolation-and-structural-elucidation-of-spirotoamide-c-and-d
#1
Dong Yang, Mostafa E Rateb, Nan Wang, Ben Shen
No abstract text is available yet for this article.
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196979/acremopeptin-a-new-peptaibol-from-acremonium-sp-pf1450
#2
Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada, Masakatsu Shibasaki
No abstract text is available yet for this article.
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196978/ivermectin-enigmatic-multifaceted-wonder-drug-continues-to-surprise-and-exceed-expectations
#3
REVIEW
Andy Crump
Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196977/synergistic-effects-of-vancomycin-and-%C3%AE-lactams-against-vancomycin-highly-resistant-staphylococcus-aureus
#4
Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya, Kazuhisa Sekimizu
We previously reported isolating vancomycin (VAN) highly resistant Staphylococcus aureus (VRSA) strains from clinical methicillin-resistant S. aureus strains by repeating steps of in vitro mutagenesis and VAN selection. Here we describe that the in vitro susceptibility of these VRSA strains to VAN was markedly increased by combined treatment with β-lactams such as ceftriaxone and oxacillin. Furthermore, in an in vivo silkworm infection model with VRSA, a combination of VAN and ceftriaxone exhibited therapeutic effects, whereas a combination of VAN and oxacillin did not...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196976/biosynthetic-studies-on-terpenoids-produced-by-streptomyces
#5
REVIEW
Tomohisa Kuzuyama
Terpenoids are a large and highly diverse group of natural products. All terpenoids are biosynthesized from isoprenyl diphosphate formed by the consecutive condensation of the five-carbon monomer isopentenyl diphosphate (IPP) to its isomer dimethylallyl diphosphate (DMAPP). Two distinct biosynthetic pathways produce the essential primary metabolites IPP and DMAPP: the 2-C-methylerythritol 4-phosphate pathway and the mevalonate pathway. The isoprenyl substrates can be cyclized by terpene cyclase into single-ring or multi-ring products, which can be further diversified by subsequent modification reactions, such as hydroxylation and glycosylation...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196975/tyropeptins-proteasome-inhibitors-produced-by-kitasatospora-sp-mk993-df2
#6
REVIEW
Isao Momose, Takumi Watanabe
Tyropeptins are new proteasome inhibitors isolated from the culture broth of Kitasatospora sp. MK993-dF2. Tyropeptins permeate cell membranes, inhibit intracellular proteasomes and reduce the degradation of ubiquitinated proteins in mammalian cells. We performed structure-based drug design and structure-activity relationship studies on tyropeptin derivatives to obtain valuable information of derivatives. Among the synthesized tyropeptin derivatives, some boronic acid derivatives exhibited potent antitumor effects against human multiple myeloma...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196974/the-efficacy-of-different-anti-microbial-metals-at-preventing-the-formation-of-and-eradicating-bacterial-biofilms-of-pathogenic-indicator-strains
#7
Natalie Gugala, Joe A Lemire, Raymond J Turner
The emergence of multidrug-resistant pathogens and the prevalence of biofilm-related infections have generated a demand for alternative anti-microbial therapies. Metals have not been explored in adequate detail for their capacity to combat infectious disease. Metal compounds can now be found in textiles, medical devices and disinfectants-yet, we know little about their efficacy against specific pathogens. To help fill this knowledge gap, we report on the anti-microbial and antibiofilm activity of seven metals: silver, copper, titanium, gallium, nickel, aluminum and zinc against three bacterial strains, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196973/two-new-polyketides-from-the-ascomycete-fungus-leptosphaeria-sp
#8
Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Erwei Li, Ling Liu
Leptosphaerins H and I (1 and 2), two new xanthone derivatives, and six known compounds, leptosphaerin F (3), monodictysin B (4), norlichexanthone (5), leptosphaerin D (6), moniliphenone (7) and emodinbianthrone (8) have been isolated from a scale-up fermentation of the ascomycete fungus Leptosphaeria sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of 1 was assigned using the modified Mosher method, whereas that of C-8a in 2 was determined via the CD data...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28196972/genus-kitasatospora-taxonomic-features-and-diversity-of-secondary-metabolites
#9
REVIEW
Yōko Takahashi
The genus Kitasatospora was proposed in 1982. Although Kitasatospora strains resemble Streptomyces strains in morphology, they are clearly different in cell-wall composition, as they contain both LL- and meso-diaminopimelic acid. Aerial and submerged spores contain LL-, while vegetative and submerged mycelia contain mainly meso- in their cell walls. Currently, 23 species have been validly proposed. Members of the genus Kitasatospora form a tight cluster and represent a legitimate genus distinct from Streptomyces on the basis of phylogenetic analysis of 16S rRNA gene sequences...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28174422/antarlides-f-h-new-members-of-the-antarlide-family-produced-by-streptomyces-sp-bb47
#10
Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi, Masaya Imoto
Castration-resistant prostate cancer (CRPC) is the most aggressive form of this disease. CRPC remains dependent on androgen receptor (AR) signaling. Therefore, a novel AR antagonist, enzalutamide, is used clinically for the treatment of men with metastatic CRPC. However, enzalutamide-resistant AR has appeared, and a new type of AR antagonist is desired. Previously, in the course of screening for a new type of AR antagonist, we isolated a series of compounds, designated antarlides A-E, that share a novel 22-membered-ring macrocyclic structure and are produced by Streptomyces sp...
February 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28174421/streptomyces-euryhalinus-sp-nov-a-new-actinomycete-isolated-from-a-mangrove-forest
#11
Kaushik Biswas, Jayanta D Choudhury, Riddhi Mahansaria, Malay Saha, Joydeep Mukherjee
A Gram-positive, aerobic, non-motile actinomycete (strain MS 3/20(T)) was isolated from the sediment of the Sundarbans mangrove forest in India. On International Streptomyces Project (ISP) medium 2, the isolate produced yellowish brown to red aerial hyphae that carried spiny-surfaced spores in a retinaculum-apertum arrangement. Whole-cell hydrolysate of the strain contained LL-diaminopimelic acid and galactose. Predominant menaquinones were MK-9(H8) and MK-9(H6). Diagnostic polar lipids were glycolipid, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, unidentified phospholipid and unidentified amino lipid...
February 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28144040/lipophilic-teicoplanin-pseudoaglycon-derivatives-are-active-against-vancomycin-and-teicoplanin-resistant-enterococci
#12
Zsolt Szűcs, Ilona Bereczki, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Eszter Ostorházi, Réka Szatmári, Pál Herczegh
A selection of nine derivatives of teicoplanin pseudoaglycon were tested in vitro against clinical vancomycin-resistant Enterococcus strains possessing vanA, vanB or both genes. The bacteria were characterized by PCR for the identification of their resistance genes. The tested compounds contain lipoic acid, different carbohydrates and aryl groups as lipophilic moieties. About one-third of the teicoplanin-resistant strains were shown to be susceptible to one or more of the glycopeptide derivatives.The Journal of Antibiotics advance online publication, 1 February 2017; doi:10...
February 1, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28119518/molecular-beacons-to-identify-gifted-microbes-for-genome-mining
#13
Richard H Baltz
Microbial genome mining is a promising technology that is revitalizing natural product discovery. It is now well documented that many bacteria with large genomes, particularly actinomycetes, encode many more secondary metabolites (SMs) than was previously known from their expressed secondary metabolomes. There are effective bioinformatics tools for counting the numbers and nature of SMs, and determining the total coding capacity from finished microbial genomes. However, these methods do not translate well to draft genomes, particularly for large SM gene clusters that contain nonribosomal peptide synthetase (NRPS) or type I polyketide synthase (PKS-I) mega-genes which are prone to fragmentation and misassembly...
January 25, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28119517/aspergone-a-new-chromanone-derivative-from-fungus-aspergillus-sp-scsio41002-derived-of-mangrove-soil-sample
#14
Bin Yang, Huaming Tao, Xiao-Chu Qin, Zhen Wang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Jian-Lin Li, Zheng-Chao Tu, Yonghong Liu
No abstract text is available yet for this article.
January 25, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28096550/the-ups-and-downs-of-drug-discovery-the-early-history-of-fidaxomicin
#15
James B McAlpine
The path from antibiotic compound discovery to the market is marked by many potholes and its negotiation is often dependent on luck and persistence. Perhaps the prime example of this is the case of the development of tiacumicin B to Fidaxomicin, where both parameters were critical and the path was particularly circuitous.The Journal of Antibiotics advance online publication, 18 January 2017; doi:10.1038/ja.2016.157.
January 18, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28096549/decatamariic-acid-a-new-mitochondrial-respiration-inhibitor-discovered-by-pesticidal-screening-using-drug-sensitive-saccharomyces-cerevisiae
#16
Yoshihiro Watanabe, Takuya Suga, Satomi Narusawa, Masato Iwatsuki, Kenichi Nonaka, Takuji Nakashima, Yasuo Shinohara, Takahiro Shiotsuki, Naoya Ichimaru, Hideto Miyoshi, Yukihiro Asami, Satoshi Ōmura, Kazuro Shiomi
A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.The Journal of Antibiotics advance online publication, 18 January 2017; doi:10...
January 18, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28096548/the-synthesis-and-evaluation-of-the-antiproliferative-activity-of-deacidified-gex1a-analogues
#17
Takamichi Imaizumi, Hiroshi Nakagawa, Ran Hori, Yasuo Watanabe, Shiro Soga, Kyoichiro Iida, Hideyuki Onodera
GEX1A/herboxidiene (1) is a natural product isolated from Streptomyces sp. and has been reported to target the pre-mRNA splicing process. Although 1 was shown to have antitumor activity in vivo, weight loss was observed in mice when 1 was consecutively administered. We assumed that the carboxylic acid moiety was one of the causes of this toxicity. In this study, a series of amide, carbamate and urea analogues of 1 were synthesized and their antiproliferative activity was evaluated in vitro. The synthesis of urea analogues featured Curtius rearrangement following amine treatment with the one-pot procedure from 1...
January 18, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28096547/trachyspic-acid-19-butyl-ester-a-new-inhibitor-of-plk1-polo-box-domain-dependent-recognition-from-uncharacterized-fungus-rkgs-f2684
#18
Toshihiko Nogawa, Noriko Ogita, Yushi Futamura, Shigenori Negishi, Nobumoto Watanabe, Hiroyuki Osada
No abstract text is available yet for this article.
January 18, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28096546/ma026-an-anti-hepatitis-c-virus-compound-opens-tight-junctions-of-the-epithelial-cell-membrane
#19
Yusuke Kanda, Youhei Yamasaki, Satomi Shimura, Shinji Kamisuki, Fumio Sugawara, Yoko Nagumo, Takeo Usui
MA026 is an antiviral natural compound against hepatitis C virus (HCV). It was recently reported that MA026 binds claudin-1 (CLDN1) and inhibits HCV infection. Although CLDN1 is an important component of tight junctions (TJ) in the epithelial cell layer, the effects of MA026 on the TJ barrier function remained to be revealed. Here we report that MA026 irreversibly opens the TJ. MA026 irreversibly increased FD4 permeability and decreased transepithelial electrical resistance (TER) for at least 5 h. Although MA026 increased Ca(2+) influx in layered MDCKII cells, the Ca(2+) influx was less than that of capsaicin, a reversible TJ opener...
January 18, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28096545/thiazomycin-nocathiacin-and-analogs-show-strong-activity-against-clinical-strains-of-drug-resistant-mycobacterium-tuberculosis
#20
Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth, David B Olsen, Katherine Young
Thiazolyl peptides are a class of natural products with potent Gram-positive antibacterial activities. Lack of aqueous solubility precluded this class of compounds from advancing to clinical evaluations. Nocathiacins and thiazomycins are sub-classes of thiazolyl peptides that are endowed with structural features amenable for chemical modifications. Semi-synthetic modifications of nocathiacin led to a series of analogs with improved water solubility, while retaining potency and antibacterial spectrum. We studied the activities of a selection of two natural products (nocathiacin and thiazomycin) as well as seven polar semi-synthetic analogs against twenty clinical strains of Mycobacterium tuberculosis with MDR phenotypes...
January 18, 2017: Journal of Antibiotics
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