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European Neurology

Min Qian, Haitao Ren, Tao Qu, Zhaohui Lu, Yueli Zou, Junying He, Yanhuan Zhao, Lin Chen, Hongzhi Guan
BACKGROUND: Neurocutaneous melanocytosis (NCM) is a poorly understood disease due to its rarity. This study aimed to summarize the characteristics of adult NCM and improve the awareness of this disease. METHODS: The clinical data of 13 adult patients with NCM were retrospectively reviewed, including neuroimages, cerebrospinal fluid (CSF), and histological features. RESULTS: There were 9 males and 4 females. The mean age at symptom onset was 36...
July 13, 2018: European Neurology
Fang Yuan, Ruihua Jia, Qiong Gao, Fang Yang, Xiai Yang, Yongli Jiang, Wen Li, Lara V Marcuse, Wen Jiang
BACKGROUND: Drug-resistant epilepsy (DRE) is a common and serious consequence of convulsive status epilepticus (CSE). Little is known on the early prediction of DRE development after CSE. Our aim was to identify independent DRE predictors in patients with CSE. METHODS: One hundred and forty consecutive patients identified with CSE in a tertiary academic hospital between March 2008 and January 2015 were reviewed. Demographics, clinical features, serum albumin neuroimaging, and electroencephalogram characteristics were collected and analyzed...
July 9, 2018: European Neurology
Junya Aoki, Kentaro Suzuki, Satoshi Suda, Seiji Okubo, Masahiro Mishina, Yasuhiro Nishiyama, Yuki Sakamoto, Kazumi Kimura
BACKGROUND: It is unknown whether the effect of onset---to-door (OTD) time on clinical outcomes differs between -patients with and without large artery occlusion (LAO) who undergo hyperacute recanalization therapy. METHODS: Hyperacute recanalization therapy includes intravenous thrombolysis tissue-plasminogen activator (tPA), and endovascular therapy (EVT). Favorable clinical outcome was defined as modified Rankin Scale of ≤2 at discharge. RESULTS: Among 164 patients, 117 (71%) patients received tPA, 86 (52%) received EVT, and 39 (24%) received tPA and EVT...
July 9, 2018: European Neurology
Ivan Adamec, Anamari Junakovic, Magdalena Krbot Skorić, Mario Habek
AIM: The aim of this study was to investigate the association of autonomic nervous system abnormalities on head-up tilt table test (HUTT) with generalized joint hypermobility, expressed by Beighton score (BS). METHODS: This was a prospective study that included 115 consecutive patients (91 females; mean age 34.35 ± 14.11) referred either for the HUTT or testing of the cardiovascular autonomic reflexes together with HUTT. Generalized joint hypermobility was evaluated according to the BS system after which HUTT was performed...
July 9, 2018: European Neurology
Bruno Niemeyer, Bernardo Muniz, Edson Marchiori
No abstract text is available yet for this article.
July 9, 2018: European Neurology
Valentina Mancini, Giulio Mastria, Viviana Frantellizzi, Alessandro Viganò, Nikolaos Petsas, Saadi Sollaku, Martina Fanella, Carlo Di Bonaventura, Mauro Liberatore, Vittorio Di Piero
No abstract text is available yet for this article.
July 9, 2018: European Neurology
Marco Luigetti, Tommaso Nicoletti, Raffaele Iorio, Claudia Papi, Vittorio Riso, Emilio Lozupone, Gabriella Silvestri
No abstract text is available yet for this article.
July 3, 2018: European Neurology
Navnika Gupta, Sanjay Pandey
BACKGROUND: After a stroke, movement disorders are rare manifestations mainly affecting the deep structures of the brain like the basal ganglia (44%) and thalamus (37%), although there have been case studies of movement disorders in strokes affecting the cerebral cortex also. SUMMARY: This review aims to delineate the various movement disorders seen in association with thalamic strokes and tries to identify the location of the nuclei affected in each of the described movement disorders...
June 5, 2018: European Neurology
Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Chunxue Wang, Yuesong Pan, Xia Meng, Yilong Wang, Yongjun Wang
OBJECTIVES: Statin use during hospitalization improves prognosis in patients with ischaemic stroke. However, it remains uncertain whether acute ischaemic stroke patients with chronic kidney disease (CKD) benefit from statin therapy. We investigated the effect of statin use during hospitalization in reducing short-term mortality of patients with ischaemic stroke and CKD. METHODS: Data of first-ever ischaemic stroke patients without a history of pre-stroke statin treatment was derived from the China National Stroke Registry...
May 31, 2018: European Neurology
(no author information available yet)
No abstract text is available yet for this article.
May 29, 2018: European Neurology
Qi Pan, Yixin Zhang, Ting Long, Wei He, Shanshan Zhang, Yulan Fan, Jiying Zhou
BACKGROUND: Dizziness and vertigo are frequent complaints of outpatients in the neurological department. Our objective was to explore the epidemiological category and clinical features of patients with dizziness or vertigo in the neurological outpatient department of a tertiary hospital. METHODS: We consecutively recruited all patients with dizziness and/or vertigo visiting the neurological outpatient clinic of the First Affiliated Hospital of Chongqing Medical University from January 2016 to June 2017...
May 24, 2018: European Neurology
Hisayoshi Oka, Atuso Nakahara, Tadashi Umehara
INTRODUCTION: Cardiovascular autonomic failure is commonly associated with Parkinson's disease (PD), affecting the daily lives of patients. Rotigotine was recently reported not to influence cardiovascular autonomic responses in contrast to other dopaminergic drugs. The effect of rotigotine on daily blood pressure (BP) fluctuations might reflect autonomic failure in patients with PD. METHODS: Twenty-five PD patients who were receiving rotigotine and 12 patients not receiving rotigotine were recruited...
May 15, 2018: European Neurology
Min-Ting Lin, Jin-Shan Yang, Ping-Ping Chen, Mei-Zhen Qian, Hui-Xia Lin, Xiao-Ping Chen, Xian-Jin Shang, Dan-Ni Wang, Yu-Chao Chen, Bin Jiang, Yi-Jun Chen, Wan-Jin Chen, Ning Wang, Shi-Rui Gan
BACKGROUND: Spinocerebellar ataxia type 3 (SCA3), which is the most common subtype of SCA worldwide, exhibits common neuropsychological symptoms such as depression. However, the contribution of depression to the severity of SCA3 has not yet been thoroughly investigated. METHODS: The present study investigated the prevalence of depression using Beck depression inventory in 104 molecularly confirmed SCA3 patients from China. The putative risk factors for depression and whether the depression could affect the severity of ataxia were established by multivariable linear regression models...
May 15, 2018: European Neurology
Laura Mechtouff, Julie Haesebaert, Marie Viprey, Valérie Tainturier, Anne Termoz, Sylvie Porthault-Chatard, Jean-Stéphane David, Laurent Derex, Norbert Nighoghossian, Anne-Marie Schott
BACKGROUND: Secondary prevention is inadequate in the first 2 years after stroke but what happens after that is less documented. The aim of this study was to assess the use and the adherence to preventive drugs 3 and 6 years after experiencing a transient ischemic attack (TIA) or an ischemic stroke (IS). METHODS: The population study was from the AVC69 cohort (IS or TIA admitted in an emergency or stroke unit in the Rhône area, France, for an IS or a TIA during a 7-month period)...
May 14, 2018: European Neurology
Jinhua Chen, Ying Chen, Jiali Pu
BACKGROUND: Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the midbrain. The pathogenesis of PD is not fully understood but is likely caused by a combination of genetic and environmental factors. Several genes are associated with the onset and progression of familial PD. There is increasing evidence that leucine-rich repeat kinase 2 (LRRK2) plays a significant role in PD pathophysiology. SUMMARY: Many studies have been conducted to elucidate the functions of LRRK2 and identify effective LRRK2 inhibitors for PD treatment...
April 27, 2018: European Neurology
Jie Cao, Zhu-Yi Su, Sha-Bei Xu, Chen-Chen Liu
PURPOSE: The study aimed to analyze the clinical characteristics, laboratory test results, neuroimaging findings, and outcomes in patients diagnosed with subacute combined degeneration (SCD). MATERIALS AND METHODS: A total of 68 patients with SCD who had been appropriately treated for no less than 6 months were included in our study. Histories, results of routine blood tests, biochemical indices, serum vitamin B12 levels, and spinal magnetic resonance imaging (MRI) findings from the patients were studied and analyzed...
April 26, 2018: European Neurology
Olivier Tschirret, Gabriela Moreno Legast, Adeline Mansuy, Nathan Mewton, Marielle Buisson, Salem Hannoun, Leila Chamard, Dominique Sappey-Marinier, Carlos El Khoury, Magali Bischoff, Audrey de Parisot, Laurent Derex, Norbert Nighoghossian, Yves Berthezène, Laura Mechtouff
BACKGROUND: Brain atrophy has shown a protective effect on the risk of early neurological deterioration (END) related to malignant edema in patients with hemispheric infarction but could be deleterious on the outcome. AIMS: We aimed to assess whether brain atrophy has an impact on the risk of END and on the outcome in severe ischemic strokes after intravenous (IV) thrombolysis. METHODS: From a prospective thrombolysis registry, 137 patients who had a National Institutes of Health Stroke Scale (NIHSS) ≥15, MRI at admission, and IV thrombolysis were included...
April 19, 2018: European Neurology
Yiqi Wang, Tianming Shi, Bo Chen, Gaoping Lin, Yuyun Xu, Yu Geng
BACKGROUND: Prominent hypointense vessel sign (PHVS) is visualized on susceptibility weighted-imaging (SWI) in acute ischaemic stroke (AIS). We aim to test if PHVS is associated with stroke outcome. METHODS: Forty patients with acute middle cerebral artery occlusion were recruited. The presence of PHVS, cortical vessel sign (CVS), brush sign (BS) and susceptibility-diffuse weighted imaging mismatch (S-D mismatch) and Alberta Stroke Program Early CT Score (ASPECTS) on SWI were compared between the good outcome group (90-day modified Rankin scale [mRS] of 0-2) and the poor outcome group (mRS of 3-6)...
April 19, 2018: European Neurology
(no author information available yet)
No abstract text is available yet for this article.
2018: European Neurology
Nobuyuki Izutsu, Yasunori Fujimoto, Naoaki Yamada, Ryuichiro Kajikawa, Kazuhiro Yoshimura, Munenori Nagashima, Akatsuki Wakayama, Toshiki Yoshimine
BACKGROUND/AIM: We previously observed spotty hyperintense lesions in the region of the perforating arteries on peri-ictal diffusion-weighted imaging (DWI); however, no report has formally described these findings. The aim of this study was to investigate focal intensities on peri-ictal DWI, and to evaluate the clinical significance of these lesions. METHODS: We conducted a retrospective review of 677 consecutive patients with seizure who completed peri-ictal DWI within 24 h after seizure onset...
2018: European Neurology
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