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Digestion

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https://www.readbyqxmd.com/read/29320766/improved-visibility-of-barrett-s-esophagus-with-linked-color-imaging-inter-and-intra-rater-reliability-and-quantitative-analysis
#1
Tsutomu Takeda, Akihito Nagahara, Kei Ishizuka, Shoki Okubo, Keiichi Haga, Maiko Suzuki, Akihito Nakajima, Hiroyuki Komori, Yoichi Akazawa, Kentaro Izumi, Kohei Matsumoto, Hiroya Ueyama, Yuji Shimada, Kenshi Matsumoto, Daisuke Asaoka, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Mariko Hojo, Shuko Nojiri, Sumio Watanabe
BACKGROUND/AIMS: To evaluate the usefulness of linked color imaging (LCI) and blue LASER imaging (BLI) in Barrett's esophagus (BE) compared with white light imaging (WLI). METHODS: Five expert and trainee endoscopists compared WLI, LCI, and BLI images obtained from 63 patients with short-segment BE. Physicians assessed visibility as follows: 5 (improved), 4 (somewhat improved), 3 (equivalent), 2 (somewhat decreased), and one (decreased). Scores were evaluated to assess visibility...
January 10, 2018: Digestion
https://www.readbyqxmd.com/read/29320764/usefulness-of-mean-corpuscular-volume-for-detection-of-advanced-colorectal-cancer-in-patients-older-than-85-years
#2
Motohiko Kato, Yoko Kubosawa, Yuichiro Hiarai, Keiichiro Abe, Tetsu Hirata, Yoshiaki Takada, Michiko Wada, Yusaku Takatori, Satoshi Kinoshita, Kaoru Takabayashi, Masahiro Kikuchi, Takashi Ohishi, Toshio Uraoka
BACKGROUND/AIMS: The aim of this study was to elucidate clinical indicators for the detection of advanced colorectal cancer (ACRC). METHODS: This was a retrospective study conducted at a tertiary hospital. This study included 333 patients older than 85 years who underwent colonoscopy from April 2006 to May 2010. The detection rate of ACRC was assessed. Then, we analyzed the association between the detection of ACRC and various background factors including mean corpuscular volume (MCV)...
January 10, 2018: Digestion
https://www.readbyqxmd.com/read/29310119/efficacy-of-reduced-dosage-of-amoxicillin-in-an-eradication-therapy-for-helicobacter-pylori-infection-in-patients-on-hemodialysis-a-randomized-controlled-trial
#3
Shu Sahara, Mitsushige Sugimoto, Hitomi Ichikawa, Takuma Kagami, Yukitoshi Sakao, Naro Ohashi, Yoshiaki Horio, Ken Sugimoto, Akihiko Kato, Takahisa Furuta, Hideo Yasuda
BACKGROUND: An optimum Helicobacter pylori-eradication regimen for hemodialysis patients is yet to be established because of different pharmacokinetics of amoxicillin involved between hemodialysis patients and healthy subjects. We investigated to establish appropriate doses of amoxicillin for H. pylori infection eradication in hemodialysis patients. METHODS: Of 409 hemodialysis patients screened for H. pylori infection, 37 H. pylori-positive patients were randomized to different 1-week eradication regimens: esomeprazole 20 mg twice a day (b...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29310115/serotonin-transporter-gene-slc6a4-polymorphism-may-be-associated-with-chinese-globus-pharyngeus-and-its-antidepressant-effects
#4
Yao Liu, Lin Jia, Shu-Man Jiang, Dong-Yun Chen, Jiang-Shun Song, Jian Xu
BACKGROUND: Although globus pharyngeus is not rare in clinical practice, little is known about its associated gene polymorphism. We investigated the association between the SLC6A4 polymorphism and globus pharyngeus and its response to treatment with antidepressants. METHODS: A total of 84 patients were diagnosed with globus pharyngeus according to Rome III, and 160 healthy controls were genotyped for the SLC6A4 polymorphism using polymerase chain reaction amplification and agarose gel electrophoresis...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29310114/the-local-defender-and-functional-mediator-gut-microbiome
#5
Hang Yang, Zhijun Duan
BACKGROUND: The gut microbiome has been developing and making adaption all the time, which is consistent with their host from the initial colonization at birth or earlier. Emerging evidence is showing that dysbiosis is involved in various diseases associated with immune, metabolism, infection, nervous system, social behaviors, and psychopathology, etc., maybe via modulating gut barrier, microbiome-gut-brain axis, or some metabolites like short-chain fatty acids (SCFAs). SUMMARY: In the review, we will conclude the recent researches related to the influence of microbiome on local structure, function, regulation, metabolism of gut, and systematic modulation to the host, as well as some affective factors such as diet or antibiotics...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29310112/hypergastrinemia-in-long-term-use-of-proton-pump-inhibitors
#6
Akiko Shiotani, Ryo Katsumata, Kyousuke Gouda, Shinya Fukushima, Rui Nakato, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hiroshi Matsumoto, Takashi Sakakibara
BACKGROUND/AIM: The use of proton pump inhibitors (PPIs) is known to lead to hypergastrinemia; however, the data in patients with atrophic gastritis is still lacking. The aim of this study was to investigate the effects of long-term PPIs use on the gastrin levels in patients with atrophic gastritis and to determine factors affecting hypergastrinemia in long-term users of PPIs. METHODS: Serum Helicobacter pylori IgG, gastrin and pepsinogen levels were measured. Atrophic gastritis was assessed by upper gastrointestinal endoscopies based on the Kimura-Takemoto classification and pepsinogen levels...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29310111/vonoprazan-is-superior-to-rabeprazole-for-healing-endoscopic-submucosal-dissection-induced-ulcers
#7
Akira Yamasaki, Toshiyuki Yoshio, Yusuke Muramatsu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Yutaka Sasaki, Junko Fujisaki
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) is a well-established minimally invasive treatment for early gastric cancer. To heal ESD-induced ulcers, we commonly prescribe proton pump inhibitors (PPIs). Vonoprazan is our new choice, which is reported to have a stronger and longer acid inhibitory effect than existing PPIs. Here, we aimed to evaluate the efficacy of vonoprazan for healing ESD-induced ulcers compared with rabeprazole. METHODS: We reviewed 190 patients who underwent ESD before and after we switched the acid secretion inhibitor from rabeprazole to vonoprazan...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29316555/intestinal-dysbiosis-secondary-to-proton-pump-inhibitor-use
#8
Yuji Naito, Kaori Kashiwagi, Tomohisa Takagi, Akira Andoh, Ryo Inoue
BACKGROUND: Gut dysbiosis associated with the use of proton-pump inhibitors (PPIs) has been found to lead to the occurrence of infectious and inflammatory adverse events. A longitudinal observational cohort study has demonstrated the heightened risk of death associated with PPI use. SUMMARY: We evaluated meta-analyses to determine the association between PPI use and infectious and inflammatory diseases. Meta-analyses showed that PPI use is a potential risk for the development of enteric infections caused by Clostridium difficile, as well as small intestinal bacterial overgrowth, spontaneous bacterial peritonitis, community-acquired pneumonia, hepatic encephalopathy, and adverse outcomes in inflammatory bowel disease...
January 6, 2018: Digestion
https://www.readbyqxmd.com/read/29136630/one-to-one-correspondence-locations-of-resected-polyps-after-endoscopic-resection-using-catcher-tagged-method-a-randomized-prospective-study
#9
Hirohito Mori, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Seiki Kobayashi, Takaharu Yagi, Tsutomu Masaki
BACKGROUND/AIMS: Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but also enables the easiest retrieval in a short time without any special device. METHODS: One hundred thirty five patients (483 polyps) were diagnosed with colorectal neoplasm, and 64 patients (225 polyps) were enrolled and randomly allocated into the Net forceps group (NET) and the Catcher Tagged group (TAG)...
November 14, 2017: Digestion
https://www.readbyqxmd.com/read/29131059/risk-factors-and-outcomes-of-emergency-room-visits-in-intestinal-beh%C3%A3-et-s-disease
#10
Jihye Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
BACKGROUND/AIMS: Intestinal Behçet's disease (BD) is a chronic recurring intestinal vasculitic disorder that can lead to emergency room (ER) visits. We aimed to investigate the independent risk factors associated with intestinal BD-related ER visits. METHODS: We retrospectively reviewed 606 patients with intestinal BD registered at the Inflammatory Bowel Disease Clinic of Severance Hospital, Seoul, Korea. RESULTS: One hundred eighty-five patients (30...
November 2, 2017: Digestion
https://www.readbyqxmd.com/read/29084399/hepatitis-c-treatment-with-sofosbuvir-and-ledipasvir-accompanied-by-immediate-improvement-in-hemoglobin-a1c
#11
Atsuyuki Ikeda, Kaori Ikeda, Atsushi Takai, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Horoshi Seno, Nobuya Inagaki, Hiroyuki Kokuryu
BACKGROUND/AIMS: Direct-acting antiviral agents (DAAs) have increased the sustained viral response rate with minimal adverse effects and short treatment duration. In addition, recent data suggest the possibility that hepatitis C virus (HCV) clearance results in rapid improvement in metabolic pathways. The aim of the present study was to evaluate whether the DAA treatment without ribavirin lowers hemoglobin A1c (HbA1c) at 12 weeks after therapy completion. METHODS: We performed an observational study to assess the effect of sofosbuvir and ledipasvir (SOF/LED) treatment on glycemic control...
October 30, 2017: Digestion
https://www.readbyqxmd.com/read/29065423/efficacy-safety-and-mucosal-healing-of-methotrexate-in-a-large-longitudinal-cohort-of-inflammatory-bowel-disease-patients
#12
Carole Rouiller-Braunschweig, Nicolas Fournier, Valérie Pittet, Jean Dudler, Pierre Michetti
BACKGROUND/AIMS: Evidence for the effectiveness of methotrexate (MTX) in treating inflammatory bowel disease (IBD) is still incomplete. This study assessed the effectiveness, safety and mucosal healing in IBD patients treated with MTX in the Swiss IBD Cohort. METHODS: Efficacy was defined by physician assessment or by CD activity index <150 points for Crohn's disease (CD) or Modified Truelove and Witts activity index <4 points for ulcerative colitis (UC), measured at least after 3 months of MTX therapy...
October 24, 2017: Digestion
https://www.readbyqxmd.com/read/29050004/study-on-clinical-factors-involved-in-helicobacter-pylori-uninfected-undifferentiated-type-early-gastric-cancer
#13
Yusuke Horiuchi, Junko Fujisaki, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: The factors associated with the pathogenesis of Helicobacter pylori-uninfected undifferentiated-type early gastric cancer (HPUGC) remain unclear. This study compared patient characteristics, including medical history and alcohol/tobacco use, of HPUGC patients with characteristics of patients with H. pylori-positive undifferentiated-type early gastric cancer (HPPGC) to clarify and gain understanding on those differences that could play a role in the pathogenesis. METHODS: This retrospective study included 282 patients who were treated endoscopically from March 2005 to March 2014...
October 19, 2017: Digestion
https://www.readbyqxmd.com/read/29032373/differentiating-clostridium-difficile-colitis-from-clostridium-difficile-colonization-in-ulcerative-colitis-a-role-for-procalcitonin
#14
Andrew R Reinink, Julajak Limsrivilai, Bethany A Reutemann, Tristan Feierabend, Emily Briggs, Krishna Rao, Peter D R Higgins
BACKGROUND/AIMS: Clostridium difficile infection (CDI) frequently complicates ulcerative colitis (UC) and can mimic disease flare. Differentiating UC flare from CDI remains a clinical challenge, particularly due to C. difficile colonization. Procalcitonin (PCT) is a serum biomarker for bacterial infections. We hypothesized that PCT would differentiate acute CDI from UC flare and C. difficile colonization. METHODS: A single-center prospective cohort study was conducted from 2013 to 2016...
October 14, 2017: Digestion
https://www.readbyqxmd.com/read/28965110/clinicopathological-assessment-of-gastric-xanthoma-as-potential-predictive-marker-of-gastric-cancer
#15
Shinji Kitamura, Naoki Muguruma, Koichi Okamoto, Toshihito Tanahashi, Akira Fukuya, Kumiko Tanaka, Daisaku Fujimoto, Tetsuo Kimura, Hiroshi Miyamoto, Yoshimi Bando, Hisashi Takeuchi, Masako Shiba, Tetsuji Takayama
BACKGROUND/AIMS: Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHODS: A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H...
September 30, 2017: Digestion
https://www.readbyqxmd.com/read/28957814/prevalence-and-incidence-of-autoimmune-pancreatitis-in-the-population-living-in-the-southwest-of-germany
#16
Alexander Schneider, Henrik Michaely, Christel Weiss, Michael Hirth, Felix Rückert, Torsten J Wilhelm, Stefan Schönberg, Alexander Marx, Manfred V Singer, J Matthias Löhr, Matthias P Ebert, Roland H Pfützer
BACKGROUND/AIMS: The prevalence and incidence of autoimmune pancreatitis (AiP) in those living in western countries are largely unknown. We aimed to determine the prevalence of AiP among patients with pancreatitis presenting to our tertiary referral center in Mannheim, Germany; and to estimate the incidence of AiP in the Southwest of Germany. METHODS: We performed a retrospective cross-sectional analysis and determined the prevalence of AiP in patients with acute pancreatitis (AP) or chronic pancreatitis (CP)...
September 29, 2017: Digestion
https://www.readbyqxmd.com/read/28957805/autoimmune-pancreatitis-in-germany-rare-but-relevant
#17
Golo Petzold, Volker Ellenrieder, Albrecht Neesse
No abstract text is available yet for this article.
September 29, 2017: Digestion
https://www.readbyqxmd.com/read/28365684/feasibility-study-of-the-three-dimensional-flexible-endoscope-in-endoscopic-submucosal-dissection-an-ex-vivo-animal-study
#18
Daisuke Kikuchi, Mitsuru Kaise, Kosuke Nomura, Takahito Toba, Yasutaka Kuribayashi, Masami Tanaka, Satoshi Yamashita, Tsukasa Furuhata, Akira Matsui, Toshifumi Mitani, Shu Hoteya, Toshiro Iizuka
BACKGROUND/AIM: Clinical application of 3-dimensional (3D) technology for flexible endoscopes has not been reported. We developed a 3D flexible endoscope and conducted a feasibility study of endoscopic submucosal dissection (ESD) in porcine stomach. METHODS: Four endoscopists used a 3D flexible endoscope to perform a total of 8 ESD procedures on resected porcine stomachs. We assessed the en bloc resection rate, perforation rate, and mechanical issues that arise during ESD...
April 1, 2017: Digestion
https://www.readbyqxmd.com/read/28355604/cutoff-pepsinogen-level-for-predicting-unintendedly-eradicated-cases-of-helicobacter-pylori-infection-in-subjects-with-seemingly-normal-pepsinogen-levels
#19
Hiroshi Kishikawa, Kayoko Kimura, Asako Ito, Kyoko Arahata, Sakiko Takarabe, Shogo Kaida, Jun Miyauchi, Soichiro Miura, Takanori Kanai, Jiro Nishida
BACKGROUNDS/AIMS: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as "Group A" and are regarded as having a low risk of gastric cancer. These "Group A" subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. METHODS: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H...
March 30, 2017: Digestion
https://www.readbyqxmd.com/read/28319947/effects-of-capsaicin-on-older-patients-with-oropharyngeal-dysphagia-a-double-blind-placebo-controlled-crossover-study
#20
Rui Nakato, Noriaki Manabe, Sayako Shimizu, Kozo Hanayama, Akiko Shiotani, Jiro Hata, Ken Haruma
BACKGROUND/AIMS: The standard of care for older patients with oropharyngeal dysphagia (OD) is poor. Stimulation of transient receptor potential vanilloid 1 might become a pharmacological strategy for these patients. This study aimed to compare the therapeutic effect of film food containing 0.75 µg of capsaicin in these patients. METHODS: In a crossover, randomized trial, 49 patients with OD were provided capsaicin or identical placebo at least 7 days apart. Patients' reported symptoms during repeated swallowing, the volume, pH and substance P (SP) concentrations in saliva, and cervical esophageal wall motion evaluated by ultrasonographic tissue Doppler imaging were obtained before and after capsaicin or placebo administration...
March 21, 2017: Digestion
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