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https://www.readbyqxmd.com/read/28521319/natural-course-of-helicobacter-pylori-infection-in-japanese-hemodialysis-patients
#1
Mitsushige Sugimoto, Shu Sahara, Hitomi Ichikawa, Yukitoshi Sakao, Naro Ohashi, Ken Sugimoto, Hideo Yasuda, Takahisa Furuta, Akira Andoh
INTRODUCTION: Helicobacter pylori (H. pylori) infection is one of the major risk factors for gastrointestinal morbidity in hemodialysis patients. Primary end point is to investigate H. pylori infection rate in hemodialysis patients. As secondary end point, we clarified whether pepsinogen (PG) level was related with H. pylori infection status in hemodialysis patients. METHODS: Serum levels of PG I, II, and anti-H. pylori IgG antibody were assessed in 500 Japanese hemodialysis patients...
May 19, 2017: Digestion
https://www.readbyqxmd.com/read/28511188/calprotectin-in-daily-practice-where-do-we-stand-in-2017
#2
Fabrizia D'Angelo, Christian Felley, Jean Louis Frossard
BACKGROUND: To make a distinction between organic and functional disease is essential for gastroenterologists in their daily practice, but it may be challenging, given the variety and aspecificity of gastrointestinal symptoms among the general population. The clinician aim is to avoid diagnostic delay and to restrict unnecessary invasive and expensive exams. SUMMARY: Faecal markers, in particular faecal calprotectin (FC), have given proof of being reliable markers of intestinal inflammation with good clinical sensitivity...
May 17, 2017: Digestion
https://www.readbyqxmd.com/read/28511171/clinical-outcome-of-patients-with-raised-intraepithelial-lymphocytes-with-normal-villous-architecture-on-duodenal-biopsy
#3
Vikrant Parihar, Roisin Stack, Alaa Alakkari, Nial Breslin, B M Ryan, Stephen Crowther, Deidre McNamara
INTRODUCTION: The finding of a raised intraepithelial lymphocytes (IELs) count with normal villous architecture is of sufficient clinical importance to be reported in routine duodenal biopsies. AIM: To study the clinical and demographic data of patients with isolated increased IELs on duodenal biopsy. METHODS: A single-tertiary-centre retrospective study was carried out with a review of medical records of patients with increased IELs. Patients from 2012 to 2014, >18 years with at least one biopsy from the second part of the duodenum with increased IELs; defined as >25 IELs/100 enterocytes, with preserved villous architecture were identified from our histopathology database with exclusion of patients with coeliac disease (CD)...
May 17, 2017: Digestion
https://www.readbyqxmd.com/read/28501868/factors-associated-with-potassium-competitive-acid-blocker-non-response-in-patients-with-proton-pump-inhibitor-refractory-gastroesophageal-reflux-disease
#4
Masatsugu Okuyama, Kenichi Nakahara, Narika Iwakura, Tomoki Hasegawa, Maizumi Oyama, Ayumi Inoue, Hirotaka Ishizu, Hiroshi Satoh, Yasuhiro Fujiwara
BACKGROUND/AIMS: Approximately 20-40% of patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) treatment. The acid-inhibitory effect of vonoprazan, a novel potassium-competitive acid blocker (P-CAB), is significantly greater when compared to the effect of PPIs. We investigated the efficacy of vonoprazan treatment for PPI-refractory GERD and factors associated with P-CAB non-response. METHODS: We enrolled 277 GERD patients receiving continuous PPI therapy...
May 13, 2017: Digestion
https://www.readbyqxmd.com/read/28494451/anthocyanins-prevent-colorectal-cancer-development-in-a-mouse-model
#5
Elisabeth Lippert, Petra Ruemmele, Florian Obermeier, Stefan Goelder, Claudia Kunst, Gerhard Rogler, Nadja Dunger, Helmut Messmann, Arndt Hartmann, Esther Endlicher
BACKGROUND: Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of an anthocyanin-rich extract from bilberries on colorectal tumour development and growth in the administration of azoxymethan (AOM)/dextran sodium sulfate (DSS) mouse model. METHODS: Colonic carcinogenesis was induced by AOM and DSS 3 or 5%, respectively, in 50 female Balb/c mice...
May 12, 2017: Digestion
https://www.readbyqxmd.com/read/28395277/exploratory-research-on-latent-esophageal-motility-disorders-in-dysphagia-patients
#6
Shinpei Kawaguchi, Toshihisa Takeuchi, Yousuke Inoue, Yoshiaki Takahashi, Haruhiko Ozaki, Kazuhiro Ota, Satoshi Harada, Shoko Edogawa, Yuichi Kojima, Hiroshi Yamashita, Takumi Fukuchi, Kiyoshi Ashida, Kazuhide Higuchi
BACKGROUND/AIMS: High-resolution manometry (HRM) has been applied to assess esophageal motility disorders. However, the frequency and types of motility disorders in patients with dysphagia, which are frequently seen in clinical practice, are not clear. We evaluated latent esophageal motility disorders associated with dysphagia. METHODS: The study included patients without erosive esophageal mucosal damage and with dysphagia symptoms refractory to at least 8 weeks of standard-dose proton pump inhibitors...
April 11, 2017: Digestion
https://www.readbyqxmd.com/read/28384644/current-standard-and-future-perspectives-in-the-treatment-of-gastrointestinal-stromal-tumors
#7
Silke Cameron, Alexander Beham, Hans-Ulrich Schildhaus
The origin of gastrointestinal stromal tumors (GIST) from interstitial cells of Cajal or their precursor cells has been understood since the early 1990s. The first mutations within the KIT-gene have been described in the late 1990s. Even though these mutations were the breakthrough of small molecular therapy, we still do not know the factors responsible for their malignant transformation. Until then, we can only speak of recurrence risk. This review gives an introduction on the current understanding of GIST and highlights the remaining questions for diagnosis, tumor progression, and treatment in progressive disease...
April 7, 2017: Digestion
https://www.readbyqxmd.com/read/28384634/poly-adp-ribose-polymerase-1-promotes-prothrombin-gene-transcription-and-produces-des-gamma-carboxy-prothrombin-in-hepatocellular-carcinoma
#8
Tatsuya Taniguchi, Kazuhiro Kishi, Tadahiko Nakagawa, Hironori Tanaka, Takahiro Tanaka, Tetsu Tomonari, Koichi Okamoto, Masahiro Sogabe, Hiroshi Miyamoto, Toshiya Okahisa, Naoki Muguruma, Mayumi Kajimoto, Ikuko Sagawa, Tetsuji Takayama
BACKGROUND AND AIM: Although des-gamma-carboxy prothrombin (DCP) is a well-known tumor marker for hepatocellular carcinoma (HCC), the mechanism of DCP production is unclear. This study aimed to investigate the mechanism how DCP is produced in HCC cells. METHODS: Levels of mRNA and DCP were analyzed by real-time polymerase chain reaction and electro-chemiluminescence immunoassay respectively. Secreted alkaline phosphatase (SEAP) expression vectors including deletion mutants of the prothrombin gene promoter were constructed for reporter gene assay...
April 7, 2017: Digestion
https://www.readbyqxmd.com/read/28384630/esophageal-cancer-new-insights-into-a-heterogenous-disease
#9
Sebastian Krug, Patrick Michl
BACKGROUND: Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. During the last decade, several landmark trials contributed to a better understanding of the disease and emphasized the importance of multimodal treatment protocols. SUMMARY: With the introduction of perioperative or neoadjuvant approaches, the survival of both subtypes of esophageal cancer has significantly improved...
April 7, 2017: Digestion
https://www.readbyqxmd.com/read/28365684/feasibility-study-of-the-three-dimensional-flexible-endoscope-in-endoscopic-submucosal-dissection-an-ex-vivo-animal-study
#10
Daisuke Kikuchi, Mitsuru Kaise, Kosuke Nomura, Takahito Toba, Yasutaka Kuribayashi, Masami Tanaka, Satoshi Yamashita, Tsukasa Furuhata, Akira Matsui, Toshifumi Mitani, Shu Hoteya, Toshiro Iizuka
BACKGROUND/AIM: Clinical application of 3-dimensional (3D) technology for flexible endoscopes has not been reported. We developed a 3D flexible endoscope and conducted a feasibility study of endoscopic submucosal dissection (ESD) in porcine stomach. METHODS: Four endoscopists used a 3D flexible endoscope to perform a total of 8 ESD procedures on resected porcine stomachs. We assessed the en bloc resection rate, perforation rate, and mechanical issues that arise during ESD...
April 1, 2017: Digestion
https://www.readbyqxmd.com/read/28355604/cutoff-pepsinogen-level-for-predicting-unintendedly-eradicated-cases-of-helicobacter-pylori-infection-in-subjects-with-seemingly-normal-pepsinogen-levels
#11
Hiroshi Kishikawa, Kayoko Kimura, Asako Ito, Kyoko Arahata, Sakiko Takarabe, Shogo Kaida, Jun Miyauchi, Soichiro Miura, Takanori Kanai, Jiro Nishida
BACKGROUNDS/AIMS: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as "Group A" and are regarded as having a low risk of gastric cancer. These "Group A" subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. METHODS: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H...
March 30, 2017: Digestion
https://www.readbyqxmd.com/read/28319947/effects-of-capsaicin-on-older-patients-with-oropharyngeal-dysphagia-a-double-blind-placebo-controlled-crossover-study
#12
Rui Nakato, Noriaki Manabe, Sayako Shimizu, Kozo Hanayama, Akiko Shiotani, Jiro Hata, Ken Haruma
BACKGROUND/AIMS: The standard of care for older patients with oropharyngeal dysphagia (OD) is poor. Stimulation of transient receptor potential vanilloid 1 might become a pharmacological strategy for these patients. This study aimed to compare the therapeutic effect of film food containing 0.75 µg of capsaicin in these patients. METHODS: In a crossover, randomized trial, 49 patients with OD were provided capsaicin or identical placebo at least 7 days apart. Patients' reported symptoms during repeated swallowing, the volume, pH and substance P (SP) concentrations in saliva, and cervical esophageal wall motion evaluated by ultrasonographic tissue Doppler imaging were obtained before and after capsaicin or placebo administration...
March 21, 2017: Digestion
https://www.readbyqxmd.com/read/28315861/the-risk-factors-for-metastasis-in-non-ampullary-duodenal-neuroendocrine-tumors-measuring-20-mm-or-less-in-diameter
#13
Waku Hatta, Tomoyuki Koike, Katsunori Iijima, Kiyotaka Asanuma, Naoki Asano, Hiroaki Musha, Yoshifumi Inomata, Toshikazu Sano, Hiroyuki Endo, Atsushi Ikehata, Toru Horii, Motoki Ohyauchi, Satoshi Yokosawa, Atsuko Kasajima, Fumiyoshi Fujishima, Hironobu Sasano, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa
BACKGROUND/AIMS: The treatment strategy for non-ampullary duodenal neuroendocrine tumors (NAD-NETs) ≤20 mm in diameter has not been established. In this study, we aimed to evaluate the detailed characteristics of NAD-NETs ≤20 mm in diameter to clarify the risk factors of subsequent metastasis. METHODS: The patients with NAD-NETs ≤20 mm in diameter who had been treated at 12 institutions between 1992 and 2013 were enrolled. Clinical records were retrieved, and histopathological findings of all cases were centrally reviewed by 2 pathologists...
March 18, 2017: Digestion
https://www.readbyqxmd.com/read/28288474/cholangiocellular-carcinoma
#14
Arndt Vogel, Anna Saborowski
BACKGROUND: Cholangiocarcinomas (CCAs) are aggressive malignancies that display features of biliary differentiation. According to their anatomical location, CCAs are commonly classified as intrahepatic and extrahepatic tumors, the latter entity being further subdivided into perihilar CCAs, also termed as Klatskin tumors, and distal tumors. While a majority of CCAs occur sporadically, established risk factors such as liver fluke infestation or primary sclerosing cholangitis exist. SUMMARY: Due to lack of efficient early screening markers, CCAs are frequently diagnosed at an advanced stage when curative surgical resection is not an option...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28288471/early-stage-gastric-cancer-can-be-found-in-improved-atrophic-mucosa-over-time-from-successful-helicobacter-pylori-eradication
#15
Atsushi Majima, Osamu Handa, Yuji Naito, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yoshito Itoh
BACKGROUND/AIMS: Early-stage gastric cancer (EGC) is detected even after successful Helicobacter pylori eradication. This study is aimed at clarifying the clinicopathological characteristics of EGC detected after successful H. pylori eradication. METHODS: This retrospective study analyzed 57 cases of EGC detected after successful H. pylori eradication and resected endoscopically at Kyoto Prefectural University of Medicine, between January 2009 and June 2014. Clinicopathological findings of 57 cases (H...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28288464/do-acid-suppressing-medications-in-inflammatory-bowel-disease-increase-risk-for-flare
#16
Andrew R Reinink
No abstract text is available yet for this article.
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28343226/the-effect-of-ineffective-esophageal-motility-on-gastroesophageal-reflux-disease
#17
Shingo Kasamatsu, Tomoaki Matsumura, Yuki Ohta, Shinsaku Hamanaka, Hideaki Ishigami, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Tatsuro Katsuno, Mai Fujie, Atsuko Kikuchi, Makoto Arai
BACKGROUND/AIMS: Ineffective esophageal motility (IEM) is the most common gastrointestinal motility disorder. Studies have reported that IEM is related to gastroesophageal reflux disease (GERD). However, the relationship between IEM and GERD remains uncertain. This study aims to clarify this relationship retrospectively. METHODS: We analyzed 195 subjects who underwent high-resolution manometry between January 2011 and September 2016. Of these subjects, 72 had normal esophageal motility (NEM) and 26 had IEM...
2017: Digestion
https://www.readbyqxmd.com/read/28288458/gastric-acid-suppression-is-associated-with-an-increased-risk-of-adverse-outcomes-in-inflammatory-bowel-disease
#18
Rajesh Shah, Peter Richardson, Hong Yu, Jennifer Kramer, Jason Ken Hou
BACKGROUND: The intestinal microbiota may influence inflammatory bowel disease (IBD) activity. Histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) can alter the intestinal microbiota. The aim of this study was to assess the relationship between H2RAs, PPIs, and IBD-related outcomes. METHODS: We conducted a case-control study of IBD patients using the Veterans Health Affairs databases. Cases were defined by their first instance of an IBD-related hospitalization or surgery and the exposure of interest was H2RA or PPI use 30 days prior to the outcome...
2017: Digestion
https://www.readbyqxmd.com/read/28226313/risk-of-cancer-in-patients-with-autoimmune-pancreatitis-a-single-center-experience-from-germany
#19
Alexander Schneider, Michael Hirth, Markus Münch, Christel Weiss, J Matthias Löhr, Matthias P Ebert, Roland H Pfützer
BACKGROUND/AIMS: Autoimmune pancreatitis (AIP) has been associated with an increased risk of malignant diseases. We aimed to describe the incidence of malignant diseases in patients with AIP compared to the general population and to characterize the clinical presentation of these patients. METHODS: We retrospectively analyzed data from 28 patients with AIP presenting to the clinic (periods 1998 until 2010, 2012 until September 2015). We retrieved the expected cancer incidence of the general population from the German cancer registry...
2017: Digestion
https://www.readbyqxmd.com/read/28214864/a-comparative-study-of-intravenous-injection-form-and-oral-jelly-form-of-alendronate-sodium-hydrate-for-bone-mineral-disorder-after-gastrectomy
#20
Chikara Kunisaki, Yusaku Tanaka, Takashi Kosaka, Hiroshi Miyamoto, Sho Sato, Hideaki Suematsu, Norio Yukawa, Kei Sato, Yusuke Izumisawa, Hirotoshi Akiyama, Masataka Taguri, Takeharu Yamanaka, Itaru Endo
BACKGROUND/AIMS: Osteoporosis is found to have high prevalence after gastrectomy and therefore, it is important to prevent this condition by means of effective medication, such as alendronate sodium hydrate. METHODS: A total number of 48 gastric cancer patients diagnosed with osteoporosis after R0 gastrectomy was registered in this study between December 2013 and August 2014. Twenty-three patients received intravenous (i.v.) alendronate sodium hydrate and 25 patients received the drug in an oral jelly form...
2017: Digestion
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