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Digestion

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https://www.readbyqxmd.com/read/29136630/one-to-one-correspondence-locations-of-resected-polyps-after-endoscopic-resection-using-catcher-tagged-method-a-randomized-prospective-study
#1
Hirohito Mori, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Seiki Kobayashi, Takaharu Yagi, Tsutomu Masaki
BACKGROUND/AIMS: Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but also enables the easiest retrieval in a short time without any special device. METHODS: One hundred thirty five patients (483 polyps) were diagnosed with colorectal neoplasm, and 64 patients (225 polyps) were enrolled and randomly allocated into the Net forceps group (NET) and the Catcher Tagged group (TAG)...
November 14, 2017: Digestion
https://www.readbyqxmd.com/read/29131059/risk-factors-and-outcomes-of-emergency-room-visits-in-intestinal-beh%C3%A3-et-s-disease
#2
Jihye Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
BACKGROUND/AIMS: Intestinal Behçet's disease (BD) is a chronic recurring intestinal vasculitic disorder that can lead to emergency room (ER) visits. We aimed to investigate the independent risk factors associated with intestinal BD-related ER visits. METHODS: We retrospectively reviewed 606 patients with intestinal BD registered at the Inflammatory Bowel Disease Clinic of Severance Hospital, Seoul, Korea. RESULTS: One hundred eighty-five patients (30...
November 2, 2017: Digestion
https://www.readbyqxmd.com/read/29084399/hepatitis-c-treatment-with-sofosbuvir-and-ledipasvir-accompanied-by-immediate-improvement-in-hemoglobin-a1c
#3
Atsuyuki Ikeda, Kaori Ikeda, Atsushi Takai, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Horoshi Seno, Nobuya Inagaki, Hiroyuki Kokuryu
BACKGROUND/AIMS: Direct-acting antiviral agents (DAAs) have increased the sustained viral response rate with minimal adverse effects and short treatment duration. In addition, recent data suggest the possibility that hepatitis C virus (HCV) clearance results in rapid improvement in metabolic pathways. The aim of the present study was to evaluate whether the DAA treatment without ribavirin lowers hemoglobin A1c (HbA1c) at 12 weeks after therapy completion. METHODS: We performed an observational study to assess the effect of sofosbuvir and ledipasvir (SOF/LED) treatment on glycemic control...
October 30, 2017: Digestion
https://www.readbyqxmd.com/read/29065423/efficacy-safety-and-mucosal-healing-of-methotrexate-in-a-large-longitudinal-cohort-of-inflammatory-bowel-disease-patients
#4
Carole Rouiller-Braunschweig, Nicolas Fournier, Valérie Pittet, Jean Dudler, Pierre Michetti
BACKGROUND/AIMS: Evidence for the effectiveness of methotrexate (MTX) in treating inflammatory bowel disease (IBD) is still incomplete. This study assessed the effectiveness, safety and mucosal healing in IBD patients treated with MTX in the Swiss IBD Cohort. METHODS: Efficacy was defined by physician assessment or by CD activity index <150 points for Crohn's disease (CD) or Modified Truelove and Witts activity index <4 points for ulcerative colitis (UC), measured at least after 3 months of MTX therapy...
October 24, 2017: Digestion
https://www.readbyqxmd.com/read/29050004/study-on-clinical-factors-involved-in-helicobacter-pylori-uninfected-undifferentiated-type-early-gastric-cancer
#5
Yusuke Horiuchi, Junko Fujisaki, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: The factors associated with the pathogenesis of Helicobacter pylori-uninfected undifferentiated-type early gastric cancer (HPUGC) remain unclear. This study compared patient characteristics, including medical history and alcohol/tobacco use, of HPUGC patients with characteristics of patients with H. pylori-positive undifferentiated-type early gastric cancer (HPPGC) to clarify and gain understanding on those differences that could play a role in the pathogenesis. METHODS: This retrospective study included 282 patients who were treated endoscopically from March 2005 to March 2014...
October 19, 2017: Digestion
https://www.readbyqxmd.com/read/29032373/differentiating-clostridium-difficile-colitis-from-clostridium-difficile-colonization-in-ulcerative-colitis-a-role-for-procalcitonin
#6
Andrew R Reinink, Julajak Limsrivilai, Bethany A Reutemann, Tristan Feierabend, Emily Briggs, Krishna Rao, Peter D R Higgins
BACKGROUND/AIMS: Clostridium difficile infection (CDI) frequently complicates ulcerative colitis (UC) and can mimic disease flare. Differentiating UC flare from CDI remains a clinical challenge, particularly due to C. difficile colonization. Procalcitonin (PCT) is a serum biomarker for bacterial infections. We hypothesized that PCT would differentiate acute CDI from UC flare and C. difficile colonization. METHODS: A single-center prospective cohort study was conducted from 2013 to 2016...
October 14, 2017: Digestion
https://www.readbyqxmd.com/read/28965110/clinicopathological-assessment-of-gastric-xanthoma-as-potential-predictive-marker-of-gastric-cancer
#7
Shinji Kitamura, Naoki Muguruma, Koichi Okamoto, Toshihito Tanahashi, Akira Fukuya, Kumiko Tanaka, Daisaku Fujimoto, Tetsuo Kimura, Hiroshi Miyamoto, Yoshimi Bando, Hisashi Takeuchi, Masako Shiba, Tetsuji Takayama
BACKGROUND/AIMS: Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHODS: A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H...
September 30, 2017: Digestion
https://www.readbyqxmd.com/read/28957814/prevalence-and-incidence-of-autoimmune-pancreatitis-in-the-population-living-in-the-southwest-of-germany
#8
Alexander Schneider, Henrik Michaely, Christel Weiss, Michael Hirth, Felix Rückert, Torsten J Wilhelm, Stefan Schönberg, Alexander Marx, Manfred V Singer, J Matthias Löhr, Matthias P Ebert, Roland H Pfützer
BACKGROUND/AIMS: The prevalence and incidence of autoimmune pancreatitis (AiP) in those living in western countries are largely unknown. We aimed to determine the prevalence of AiP among patients with pancreatitis presenting to our tertiary referral center in Mannheim, Germany; and to estimate the incidence of AiP in the Southwest of Germany. METHODS: We performed a retrospective cross-sectional analysis and determined the prevalence of AiP in patients with acute pancreatitis (AP) or chronic pancreatitis (CP)...
September 29, 2017: Digestion
https://www.readbyqxmd.com/read/28957805/autoimmune-pancreatitis-in-germany-rare-but-relevant
#9
Golo Petzold, Volker Ellenrieder, Albrecht Neesse
No abstract text is available yet for this article.
September 29, 2017: Digestion
https://www.readbyqxmd.com/read/28384634/poly-adp-ribose-polymerase-1-promotes-prothrombin-gene-transcription-and-produces-des-gamma-carboxy-prothrombin-in-hepatocellular-carcinoma
#10
Tatsuya Taniguchi, Kazuhiro Kishi, Tadahiko Nakagawa, Hironori Tanaka, Takahiro Tanaka, Tetsu Tomonari, Koichi Okamoto, Masahiro Sogabe, Hiroshi Miyamoto, Toshiya Okahisa, Naoki Muguruma, Mayumi Kajimoto, Ikuko Sagawa, Tetsuji Takayama
BACKGROUND AND AIM: Although des-gamma-carboxy prothrombin (DCP) is a well-known tumor marker for hepatocellular carcinoma (HCC), the mechanism of DCP production is unclear. This study aimed to investigate the mechanism how DCP is produced in HCC cells. METHODS: Levels of mRNA and DCP were analyzed by real-time polymerase chain reaction and electro-chemiluminescence immunoassay respectively. Secreted alkaline phosphatase (SEAP) expression vectors including deletion mutants of the prothrombin gene promoter were constructed for reporter gene assay...
April 7, 2017: Digestion
https://www.readbyqxmd.com/read/28365684/feasibility-study-of-the-three-dimensional-flexible-endoscope-in-endoscopic-submucosal-dissection-an-ex-vivo-animal-study
#11
Daisuke Kikuchi, Mitsuru Kaise, Kosuke Nomura, Takahito Toba, Yasutaka Kuribayashi, Masami Tanaka, Satoshi Yamashita, Tsukasa Furuhata, Akira Matsui, Toshifumi Mitani, Shu Hoteya, Toshiro Iizuka
BACKGROUND/AIM: Clinical application of 3-dimensional (3D) technology for flexible endoscopes has not been reported. We developed a 3D flexible endoscope and conducted a feasibility study of endoscopic submucosal dissection (ESD) in porcine stomach. METHODS: Four endoscopists used a 3D flexible endoscope to perform a total of 8 ESD procedures on resected porcine stomachs. We assessed the en bloc resection rate, perforation rate, and mechanical issues that arise during ESD...
April 1, 2017: Digestion
https://www.readbyqxmd.com/read/28355604/cutoff-pepsinogen-level-for-predicting-unintendedly-eradicated-cases-of-helicobacter-pylori-infection-in-subjects-with-seemingly-normal-pepsinogen-levels
#12
Hiroshi Kishikawa, Kayoko Kimura, Asako Ito, Kyoko Arahata, Sakiko Takarabe, Shogo Kaida, Jun Miyauchi, Soichiro Miura, Takanori Kanai, Jiro Nishida
BACKGROUNDS/AIMS: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as "Group A" and are regarded as having a low risk of gastric cancer. These "Group A" subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. METHODS: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H...
March 30, 2017: Digestion
https://www.readbyqxmd.com/read/28319947/effects-of-capsaicin-on-older-patients-with-oropharyngeal-dysphagia-a-double-blind-placebo-controlled-crossover-study
#13
Rui Nakato, Noriaki Manabe, Sayako Shimizu, Kozo Hanayama, Akiko Shiotani, Jiro Hata, Ken Haruma
BACKGROUND/AIMS: The standard of care for older patients with oropharyngeal dysphagia (OD) is poor. Stimulation of transient receptor potential vanilloid 1 might become a pharmacological strategy for these patients. This study aimed to compare the therapeutic effect of film food containing 0.75 µg of capsaicin in these patients. METHODS: In a crossover, randomized trial, 49 patients with OD were provided capsaicin or identical placebo at least 7 days apart. Patients' reported symptoms during repeated swallowing, the volume, pH and substance P (SP) concentrations in saliva, and cervical esophageal wall motion evaluated by ultrasonographic tissue Doppler imaging were obtained before and after capsaicin or placebo administration...
March 21, 2017: Digestion
https://www.readbyqxmd.com/read/28288471/early-stage-gastric-cancer-can-be-found-in-improved-atrophic-mucosa-over-time-from-successful-helicobacter-pylori-eradication
#14
Atsushi Majima, Osamu Handa, Yuji Naito, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yoshito Itoh
BACKGROUND/AIMS: Early-stage gastric cancer (EGC) is detected even after successful Helicobacter pylori eradication. This study is aimed at clarifying the clinicopathological characteristics of EGC detected after successful H. pylori eradication. METHODS: This retrospective study analyzed 57 cases of EGC detected after successful H. pylori eradication and resected endoscopically at Kyoto Prefectural University of Medicine, between January 2009 and June 2014. Clinicopathological findings of 57 cases (H...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28288464/do-acid-suppressing-medications-in-inflammatory-bowel-disease-increase-risk-for-flare
#15
Andrew R Reinink
No abstract text is available yet for this article.
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28968604/erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
2017: Digestion
https://www.readbyqxmd.com/read/28946145/impact-of-cyclooxygenase-2-1195-g-carrier-genotype-associated-with-intestinal-metaplasia-and-endoscopic-findings-based-on-kyoto-classification
#17
Yasuhiro Kodaka, Seiji Futagami, Atsushi Tatsuguchi, Hiroshi Yamawaki, Hitomi Sato, Satomi Hashimoto, Tetsuro Kawagoe, Nobue Ueki, Hiroyuki Nagoya, Yuuta Maruki, Kazumasa Miyake, Katya Gudis, Choitsu Sakamoto, Katsuhiko Iwakiri
BACKGROUND/AIMS: We aimed to clarify whether cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) genotypes were associated with certain histological findings and endoscopical appearances based on Kyoto classification. METHODS: We enrolled 285 Helicobacter pylori-infected gastritis patients. Genotypes of COX-2 1195, COX-2 1290, mPGES-1, interleukin-1β (IL-1β) 511 and tumour necrosis factor-α (TNF-α) 308 were analyzed. Genotyping was performed by polymerase chain reaction...
2017: Digestion
https://www.readbyqxmd.com/read/28903094/effectiveness-of-mesalazine-thiopurines-and-tumour-necrosis-factor-antagonists-in-preventing-post-operative-crohn-s-disease-recurrence-in-a-real-life-setting
#18
Mariangela Allocca, Rosario Landi, Stefanos Bonovas, Gionata Fiorino, Alfredo Papa, Antonino Spinelli, Federica Furfaro, Laurent Peyrin-Biroulet, Alessandro Armuzzi, Silvio Danese
BACKGROUND: Most Crohn's disease (CD) patients develop endoscopic recurrence within one year of intestinal resection. The best treatment method to prevent post-operative CD recurrence remains uncertain. METHODS: A total of 155 CD patients from 2 referral centres, who were undergoing intestinal resection with ileo-colonic anastomosis (January 2004-January 2015), were included. All subjects received preventive therapy with tumour necrosis factor antagonists (anti-TNFs), thiopurinesor mesalazine...
2017: Digestion
https://www.readbyqxmd.com/read/28858864/early-intervention-with-infliximab-prevents-reoperation-in-crohn-s-disease-a-single-center-retrospective-analysis
#19
Manabu Ishii, Ken-Ichi Tarumi, Akiko Shiotani, Tomoari Kamada, Minoru Fujita, Hiroshi Matsumoto, Takahisa Murao, Noriaki Manabe, Hiroaki Kusunoki, Jiro Hata, Ken Haruma
BACKGROUND/AIMS: We aimed to evaluate the prognostic factors that can aid in the prevention of first and second surgeries in patients with Crohn's disease (CD). METHODS: The clinical records of 115 patients with CD whose disease onset was between January 1987 and July 2012 were retrospectively investigated. The cumulative rate of bowel resection for CD-related intestinal manifestations following onset until the first surgery and the cumulative rate of reoperation following the first to second surgeries were estimated using the Kaplan-Meier method, and the relationship to each factor was statistically analyzed using the log-rank test...
2017: Digestion
https://www.readbyqxmd.com/read/28854423/nonampullary-duodenal-adenomas-rarely-recur-after-complete-endoscopic-resection-a-swiss-experience-including-a-literature-review
#20
Piero V Valli, Joachim C Mertens, Amnon Sonnenberg, Peter Bauerfeind
INTRODUCTION: Duodenal polyps and especially duodenal adenomas are a rare and mostly coincidental finding in patients undergoing upper gastrointestinal endoscopy. Due to their malignant potential, duodenal adenomas should be removed upon diagnosis. So far, the limited available data on the performance of endoscopic polypectomy show conflicting results with regard to adverse events and the adenoma recurrence rate. PATIENTS AND METHODS: After summarizing the currently available data, we retrospectively analyzed all patients undergoing endoscopic resection of nonampullary duodenal adenomas (NAD) at our institution between 2006 and 2016...
2017: Digestion
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