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Yize R Wang, Edward V Loftus, Thomas A Judge, Steven R Peikin
BACKGROUND AND AIMS: In the United States, little is known about the rates of interval upper gastrointestinal (GI) cancer (possibly missed out) after an esophagogastroduodenoscopy (EGD) is performed. Data from non-US studies reported interval cancer rates of 7-26%. We aimed to study the rate and predictors of interval upper GI cancers in the United States. METHODS: Using the random 5% sample of Medicare beneficiaries in the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified patients diagnosed with esophageal or gastric cancer during 2000-2007...
November 22, 2016: Digestion
Lei Huang, Baofeng Du, Yaoyao Gong, Hairong Xu, Jia Lu, Xinmin Si
OBJECTIVES: To evaluate the role of exogenous interleukin-9 (IL-9) in the growth, proliferation and activity of interstitial cells of Cajal (ICCs) cultured in vitro, and to assess its role in maintaining the functions of ICCs. METHODS: ICCs of murine gastric antrum were isolated and cultured in vitro. ICCs were identified with c-Kit and ANO1 immunofluorescent antibodies. Both fluorescence microscope and confocal microscopy were used to observe the effects of IL-9 on the growth, proliferation and activity of ICCs in cultured in vitro...
November 11, 2016: Digestion
Hang Yang, Zhijun Duan
BACKGROUND: Bile acids (BAs) play a potential role in regulating the whole-body metabolic homeostasis via the interaction with gut microbiome and the signal transduction as messengers, which establish a link between the primary biliary cirrhosis (PBC) and gut microbiome in many aspects, particularly with regard to the immune system of the body. PBC, as a chronic cholestatic liver disease characterised by the destruction of small intrahepatic bile ducts, causes fibrosis and potential cirrhosis without efficient therapies...
November 11, 2016: Digestion
Yui Jennifer Kimura, Shin-Ei Kudo, Hideyuki Miyachi, Katsuro Ichimasa, Yuta Kouyama, Masashi Misawa, Yuta Sato, Shingo Matsudaira, Hiromasa Oikawa, Tomokazu Hisayuki, Yuichi Mori, Toyoki Kudo, Noriyuki Ogata, Kenta Kodama, Kunihiko Wakamura, Takemasa Hayashi, Atsushi Katagiri, Toshiyuki Baba, Eiji Hidaka, Fumio Ishida, Shigeharu Hamatani
BACKGROUND/AIM: Previous reports stated that pedunculated T1 colorectal carcinomas with 'head invasion' showed almost no nodal metastasis, requiring endoscopic treatment alone. However, clinically, some lesions develop nodal metastasis. We aimed to validate the necessity of distinguishing between 'pedunculated' and 'non-pedunculated' lesions, and also between 'head' and 'stalk' invasions. METHODS: Initial or additional surgery with lymph node dissection was performed in 76 pedunculated and 594 non-pedunculated cases...
November 11, 2016: Digestion
Johannes Betge, Ana Barat, Verena Murphy, Thomas Hielscher, Nicole C Van Grieken, Sebastian Belle, Tianzuo Zhan, Nicolai Härtel, Melanie Kripp, Orna Bacon, Martijn Cordes, Elaine W Kay, Henk M W Verheul, Maarten Neerincx, Bryan Hennessy, Ralf D Hofheinz, Timo Gaiser, Bauke Ylstra, Jochen H M Prehn, Diether Lambrechts, Annette T Byrne, Matthias P Ebert, Nadine Schulte
BACKGROUND/AIMS: This study is aimed at analyzing the survival rates and prognostic factors of stage IV colorectal cancer patients from 3 European cohorts undergoing combination chemotherapy with bevacizumab. METHODS: Progression free-survival (PFS) and overall survival (OS) were analyzed in 172 patients using the Kaplan-Meier method and uni- and multivariable Cox proportional hazards regression models. RESULTS: The median PFS was 9.7 and the median OS 27...
October 19, 2016: Digestion
Matthias Buechter, Alisan Kahraman, Paul Manka, Guido Gerken, Christoph Jochum, Ali Canbay, Alexander Dechêne
BACKGROUND/AIMS: Portal hypertension (PH) is a common complication of chronic liver disease and results in esophageal and gastric variceal bleeding, which is associated with a high mortality rate. Measurement of the hepatic venous pressure gradient (HVPG) is considered the gold standard for diagnosing PH and estimating the risk of varices and bleeding. In contrast, upper gastrointestinal (GI) endoscopy (UGE) can reliably demonstrate the presence of varices and bleeding. Both measures are invasive, and HVPG is mainly restricted to tertiary centers...
October 19, 2016: Digestion
Daisuke Kikuchi, Toshiro Iizuka, Akihiro Yamada, Kosuke Nomura, Yasutaka Kuribayashi, Ryusuke Kimura, Shu Hoteya, Mitsuru Kaise
BACKGROUND/AIM: We developed a new device for the simultaneous manipulation of an endoscope and treatment devices, which we named the Smart Shooter®. The aim of this study was to validate the feasibility of using the Smart Shooter® in endoscopic submucosal dissection (ESD). METHODS: This pilot feasibility study conducted between March and June 2014 involved 20 consecutive patients who underwent ESD for superficial gastrointestinal neoplasia. The primary endpoint was a serious adverse event during the ESD procedure...
October 19, 2016: Digestion
Eugen Zizer, Johanna Backhus, Stephan Bohl, Anette Braun, Irina Baturina, Dietmar Klass, Nektarios Dikopoulos, Thomas Seufferlein, Matthias Dollinger
BACKGROUND/AIM: The assessment of advanced chronic liver disease (ACLD) is a prerequisite for therapy and surveillance in patients with chronic hepatitis C infection. Mini-laparoscopy-assisted liver biopsies facilitate both histological and macroscopical evaluation of liver fibrosis. This study is aimed at investigating the prognostic significance of the laparoscopic assessment for the cumulative incidence of ACLD-related events. PATIENTS AND METHODS: We performed a single center, retrospective analysis of 94 patients with either macroscopically or/and microscopically assessed advanced fibrosis/cirrhosis caused by chronic hepatitis C infection...
October 6, 2016: Digestion
Makoto Sanomura, Shinji Tanaka, Yuichi Sasaki, Shinya Fukunishi, Kazuhide Higuchi
BACKGROUND/AIMS: We established a new colorectal T1 invasion depth sub-classification and evaluated it to determine whether total excisional biopsy can be performed on colorectal carcinoma (CRC) cases using narrow-band imaging (NBI) magnification. METHODS: The cases included 73 T1 carcinomas selected from 173 early CRC cases. The T1 invasion depth sub-classification was defined as follows: T1a, invasion less than 1,000 μm from the inferior border of the muscularis mucosae; T1b-1, between T1a and T1b-2; and T1b-2, T1b lesions with invasion from the deepest part of the carcinoma to within 1,000 μm of the superior border of the muscularis propria...
September 28, 2016: Digestion
Kazushige Kawai, Soichiro Ishihara, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Koji Murono, Kazuhito Sasaki, Toshiaki Watanabe
BACKGROUND/AIMS: Colorectal cancer (CRC) patients are at high risk for developing extracolorectal malignancies (EMs). Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not been fully investigated. METHODS: A total of 1,625 CRC patients who underwent surgery from April 2004 to March 2014 were retrospectively evaluated...
September 17, 2016: Digestion
Jingu Kang, Kyu-Hyun Paik, Jong-Chan Lee, Hyoung Woo Kim, Jongchan Lee, Jin-Hyeok Hwang, Jaihwan Kim
BACKGROUND/AIMS: For the suspected choledocholithiasis, the American Society for Gastrointestinal Endoscopy has proposed guidelines to assign risk based on clinical predictors. The study aimed to assess the usefulness of clinical predictors of choledocholithiasis set forth by the guidelines in patients with intermediate risk of choledocholithiasis. METHODS: In 2014, 109 patients with intermediate risk of choledocholithiasis underwent endoscopic ultrasound. Their medical records were retrospectively reviewed...
September 17, 2016: Digestion
Yoon Suk Jung, Chang Kyun Lee, Chang Soo Eun, Dong Il Park, Dong Soo Han, Hyo Jong Kim
BACKGROUND: Minimal data exist regarding the use of low-volume purgatives for elderly (≥65 years) patients. We aimed to investigate the bowel-cleansing efficacy and patient tolerability of split-dose 2 liters (L)-polyethylene glycol with ascorbic acid (2L-PEGA) in elderly outpatients undergoing colonoscopy. METHODS: Patients who underwent morning colonoscopies were randomly assigned to one of 3 arms: single-dose 4L-PEG on the day before colonoscopy; split-dose 4L-PEG; or split-dose 2L-PEGA...
August 24, 2016: Digestion
Masaki Ominami, Yasuaki Nagami, Masatsugu Shiba, Kazunari Tominaga, Hirotsugu Maruyama, Junichi Okamoto, Kunihiro Kato, Hiroaki Minamino, Shusei Fukunaga, Satoshi Sugimori, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
BACKGROUND/AIMS: Modified neuroleptanalgesia (m-NLA) with midazolam is often used for sedation and analgesia during endoscopic submucosal dissection (ESD) for gastrointestinal neoplasia. However, interruption due to poor response to midazolam is often experienced during ESD for esophageal squamous cell carcinoma (ESCC) because most patients with ESCC have a history of heavy alcohol intake. We examined the incidence and risk factors for poor response to m-NLA with midazolam and pethidine hydrochloride...
August 20, 2016: Digestion
Yoshiharu Yamaguchi, Kazunori Adachi, Tomoya Sugiyama, Akihiro Shimozato, Masahide Ebi, Naotaka Ogasawara, Yasushi Funaki, Chiho Goto, Makoto Sasaki, Kunio Kasugai
BACKGROUND/AIMS: Evidence suggests that intestinal microbiota, along with factors such as diet and host genetics, contributes to obesity, metabolic dysfunction and diabetes. Therefore, we examined the relationship between gut microbiota, blood metabolic markers, dietary habits and fecal short-chain fatty acids (SCFAs) in patients with type 2 diabetes mellitus (T2DM). METHODS: Dietary habits, blood and fecal samples from 59 T2DM patients were recruited, and the association of intestinal microbiota with metabolic markers and dietary habits was analyzed...
August 10, 2016: Digestion
Lorena Brandariz, Cristina Alegre, Daniel Rueda, Maria Arriba, Laura Alonso, Anisa Nutu, Yolanda Rodríguez, José Antonio Pajares, Eduardo Ferrero, Javier García-Borda, José Perea
BACKGROUND: We identify the features of multiple primary colorectal cancer (MPCC), synchronous colorectal cancer (SCRC) and metachronous colorectal cancer (MCRC), and distinguish between the cases that require a more extensive surgery and those where the parameters of SCRC might be important to prevent the development of MCRC. METHODS: We gathered up consecutive individuals with MPCC, 50 for each category, and 100 consecutive individuals diagnosed with 'single' colorectal cancer...
August 5, 2016: Digestion
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No abstract text is available yet for this article.
2016: Digestion
Jørgen Valeur, Arne Gustav Røseth, Torunn Knudsen, Gunn Helen Malmstrøm, Jennifer T Fiennes, Tore Midtvedt, Arnold Berstad
BACKGROUND/AIMS: Dietary restriction of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) may relieve symptoms in patients with irritable bowel syndrome (IBS). We investigated whether this diet alters microbial fermentation, a process that may be involved in IBS symptom generation. METHODS: Patients with IBS were included consecutively to participate in a 4-week FODMAP restricted diet. IBS symptoms were evaluated by using the IBS severity scoring system (IBS-SSS)...
2016: Digestion
Isao Fujita, Tatsuya Toyokawa, Katsunori Matsueda, Shizuma Omote, Akiko Fujita, Yuya Ueda, Shinya Endo, Rika Omote, Kazuo Watanabe, Joichiro Horii, Takako Murakami, Jun Tomoda
BACKGROUND/AIMS: This prospective cohort study aimed to elucidate the incidence and characteristics of pneumonia associated with endoscopic submucosal dissection (ESD) of gastric neoplasms using CT. METHODS: We included consecutive 188 patients with gastric neoplasms treated with ESD. All patients underwent CT before ESD and the day after ESD. Pneumonia associated with ESD was defined as lung ground glass opacity or consolidation by CT the day after ESD. RESULTS: In 188 patients, 28 patients had diabetes mellitus...
2016: Digestion
Volker Ellenrieder, Alexander König, Thomas Seufferlein
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a median 5-year survival of <8%. At the time of diagnosis, a vast majority of pancreatic cancer patients were found to be with either metastatic spread of the disease or locally advanced tumors. Despite relatively low efficacy, gemcitabine administration was the first choice chemotherapeutic strategy in advanced PDAC for many years. In the last 5 years, however, our understanding of pancreatic carcinogenesis has improved dramatically and with this our therapeutic options have expanded significantly...
2016: Digestion
Takahito Sugase, Tsuyoshi Takahashi, Kiyokazu Nakajima, Seiichi Hirota, Toru Masuzawa, Toshirou Nishida, Yutaka Kimura, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
BACKGROUND: Duodenal gastrointestinal stromal tumors (GISTs) are a rare subset of GISTs (3-5%), and their clinicopathological features have not been fully described. The purpose of this retrospective study was to examine these characteristics and compare the operative procedures. METHODS: Twenty-five patients with duodenal GIST underwent complete resection, local resection (LR) or pancreaticoduodenectomy (PD) from 1990 to 2014 at our 2 hospitals. We analyzed patient characteristics, treatments, histological examinations, postoperative complications and survival outcomes...
2016: Digestion
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