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Tomoki Shimizu, Junko Fujisaki, Masami Omae, Akira Yamasaki, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Tomohiro Tsuchida
BACKGROUND: In recent years, effective outcomes of endoscopic submucosal dissection (ESD) for esophagogastric junction cancer including short-segment Barrett's esophagus (SSBE) cancer have been reported. However, the efficacy of ESD for long-segment Barrett's esophagus (LSBE) cancer is unknown. AIM: To clarify the treatment outcomes of ESD for LSBE cancer versus SSBE cancer. METHODS: A total of 86 patients with 91 superficial Barrett's esophageal adenocarcinomas who underwent ESD were enrolled; of these, 68 had underlying SSBE and 18 had LSBE...
March 14, 2018: Digestion
Yu Sasaki, Yasuhiko Abe, Hiroaki Takeda, Shoichi Nishise, Takao Yaoita, Makoto Yagi, Kazuhiro Sakuta, Naoko Mizumoto, Masakuni Shoji, Yusuke Onozato, Sumio Kawata, Yoshiyuki Ueno
BACKGROUND/AIMS: Obesity and insulin resistance are associated with an increased risk of colorectal adenoma (CRA). Glucagon-like peptide-1 (GLP-1) plays an important role in glucose homeostasis through its amplification of insulin secretion in response to oral nutrients; however, its role in human CRA remains unknown. We investigated oral glucose-mediated GLP-1 secretion in patients with adenoma. METHODS: We performed a case-control study of 15 nondiabetic patients with pathologically diagnosed CRA and 10 age-matched healthy controls without adenoma...
March 14, 2018: Digestion
Masaaki Kodama, Tadayoshi Okimoto, Kazuhiro Mizukami, Hisanori Abe, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Osamu Matsunari, Yuka Hirashita, Ryugo Sato, Takashi Abe, Takayuki Nagai, Tsuyoshi Arita, Kazunari Murakami
BACKGROUND/AIMS: The rate of gastric cancer (GC) after Helicobacter pylori eradication has gradually increased; therefore, we investigate the clinicopathological features of GC following eradication in comparison with those of GC with H. pylori infection. METHODS: This study included 50 subjects with GC after eradication (GCE) and 151 patients with GC with H. pylori infection (GCI). Clinicopathological factors were assessed. The manifestation of GC was further evaluated using immunohistochemical analysis and in situ hybridization...
March 7, 2018: Digestion
Małgorzata Jamka, Anita Arslanow, Annika Bohner, Marcin Krawczyk, Susanne N Weber, Frank Grünhage, Frank Lammert, Caroline S Stokes
BACKGROUND/AIMS: Common genetic variations in vitamin D metabolism are associated with liver stiffness. Whether these genes are implicated in hepatic steatosis remains unclear. Here we aimed to analyse the association of common vitamin D pathway gene variants with liver steatosis. METHODS: Liver steatosis was assessed non-invasively in 241 patients with chronic liver conditions by controlled attenuation parameter (CAP). The following polymorphisms were genotyped using TaqMan assays: group-specific component (GC) rs7041, 7-dehydrocholesterol reductase (DHCR7) rs12785878, cytochrome P450 2R1 (CYP2R1) rs10741657, -vitamin D receptor (VDR) rs7974353...
March 7, 2018: Digestion
Mariko Umezawa, Noriyuki Kawami, Shintaro Hoshino, Yoshimasa Hoshikawa, Eriko Koizumi, Nana Takenouchi, Yuriko Hanada, Mitsuru Kaise, Katsuhiko Iwakiri
BACKGROUND: The study aimed to evaluate the efficacy of on-demand therapy using 20-mg vonoprazan for mild reflux esophagitis (RE). METHODS: On-demand therapy by taking one 20-mg tablet of vonoprazan only when reflux symptoms occurred was performed for 24 weeks using 30 patients with mild RE who were receiving maintenance therapy with proton pomp inhibitors (PPIs). The presence or absence of RE, degree of overall satisfaction with the treatment, score of symptoms, and fasting gastrin level before breakfast were examined before and after on-demand therapy...
March 7, 2018: Digestion
Yosuke Toya, Masaki Endo, Risaburo Akasaka, Jun Urushikubo, Takahiro Gonai, Kensuke Asakura, Shunichi Yanai, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Shotaro Nakamura, Tamotsu Sugai, Takayuki Matsumoto
BACKGROUND AND AIMS: We aimed to investigate an association between clinicopathological features, including immunohistochemical mucin phenotypes, and magnifying chromoendoscopic findings with crystal violet staining (ME-CV) in non-ampullary duodenal epithelial tumors (NADETs). METHODS: A total of 55 patients with NADET were divided into 3 groups by mucin phenotype: intestinal, gastrointestinal, or gastric. ME-CV findings were classified into 4 patterns: convoluted, leaf-like, reticular/sulciolar, and pinecone...
February 9, 2018: Digestion
Yan Xu, Ji Jia, Chuangbo Xie, Youping Wu, Weifeng Tu
BACKGROUND: Activation of substance P (SP) contributes to the development and maintenance of gastric lesions, but the mechanisms underlying the release of SP and SP-mediated damage to the gastric mucosa remain unknown. Transient receptor potential ankyrin 1 (TRPA1) is expressed in SP-positive neurons in the dorsal root ganglion (DRG) and stomach of rats. We hypothesized that water immersion restraint stress (WIRS) may activate and sensitize TRPA1 in DRG neurons, subsequently inducing the release of SP from DRG and stomach cells, causing the development of acute gastric mucosal lesions (AGML)...
February 9, 2018: Digestion
Satoko Matsuura, Yasuhisa Sakata, Nanae Tsuruoka, Koichi Miyahara, Megumi Hara, Yoichiro Ito, Kenichiro Nakayama, Takuya Shimamura, Takahiro Noda, Takahiro Yukimoto, Ryo Shimoda, Ryuichi Iwakiri, Kazuma Fujimoto
BACKGROUND: The aim of the present study was to determine differences in the prognosis of patients in Japan who underwent emergency endoscopic hemostasis (i) during regular hours versus off hours and (ii) as outpatients versus hospitalized patients. METHODS: The present retrospective study included 443 patients who underwent emergency endoscopic hemostasis for non-variceal upper gastrointestinal bleeding from January 2008 to December 2014. These patients were classified into 2 groups: hospitalized patients and outpatients...
February 9, 2018: Digestion
Marcus Hollenbach, Jürgen Feisthammel, Joachim Mössner, Albrecht Hoffmeister
BACKGROUND: Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of BDS. METHODS: We used a modified approach of PTCD with a 13-french (Fr) hemostasis introducer for transhepatic access to BDS. Short-wired balloon or basket catheter were applied for safe removal of BDS...
February 9, 2018: Digestion
Yoji Sanomura, Shiro Oka, Shinji Tanaka, Naoki Yorita, Kazutaka Kuroki, Mio Kurihara, Takeshi Mizumoto, Yoshikazu Yoshifuku, Kazuaki Chayama
BACKGROUND: Although bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) remains problematic, especially in patients taking anticoagulants, there are differing views on the ideal and optimal management for these patients. This study investigated the risk of bleeding after ESD in patients taking anticoagulants. METHODS: We enrolled 61 consecutive patients taking anticoagulants (anticoagulant group) and 968 patients taking no antithrombotic agents (non-antithrombotic group) treated with ESD for EGC between December 2010 and October 2016...
February 8, 2018: Digestion
Zhiquan Fu, Yanting Shen, Liubing Lin, Yirong Chen, Yong Li, Renye Que
BACKGROUND/AIMS: This article was undertaken to investigate the association of toll-like receptor 4 (TLR4) polymorphism (Thr399Ile) and risk of Crohn's disease (CD) by performing a meta-analysis. METHODS: Articles were chosen based on PubMed, Embase, China National Knowledge Internet, and Chinese Wanfang databases (up to 12th October 2016). Specific inclusion criteria were used to evaluate articles. Meta-analysis was performed by using a random or fixed effect model...
February 8, 2018: Digestion
Nanae Tsuruoka, Ryuichi Iwakiri, Yasuhisa Sakata, Kazuma Fujimoto, Takeshi Kamiya, Takashi Joh, Kengo Tokunaga, Shin'ichi Takahashi, Yoshikazu Kinoshita, Kazuhiko Uchiyama, Yuji Naito, Akihito Nagahara, Toshio Watanabe, Francis K L Chan, Ki-Baik Hahm, Udom Kachintorn, Kwong Ming Fock, Ari Fahrial Syam, Abdul Aziz Rani, Jose D Sollano, Qi Zhu
OBJECTIVE: Guidelines on the management of antithrombotic therapy for endoscopic procedures vary among countries. Differences in the management of antithrombotic agents for endoscopic procedures between Western and Eastern countries have already been reported. However, no study has investigated the differences among Asian countries. The aim of this study was to examine the differences in the etiology of gastrointestinal bleeding and management of antithrombotic agents during endoscopic procedures between Japan and other Asian countries (OAC)...
February 2, 2018: Digestion
Koji Otani, Toshio Watanabe, Sunao Shimada, Shuhei Hosomi, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Yasuhiro Fujiwara
BACKGROUND: Obscure gastrointestinal bleeding (OGIB) is a common but embarrassing problem for gastroenterologists. Most bleeding lesions associated with OGIB are present in the small intestine and sometimes cannot be identified due to the difficulty associated with physical accessibility. Capsule endoscopy (CE) and double-balloon enteroscopy (DBE) have enabled in the process of diagnosing and have evolved to become approaches to treating OGIB. SUMMARY: CE is a minimally invasive procedure and has a high diagnostic yield in patients with OGIB...
February 1, 2018: Digestion
Masanobu Nakajima, Hiroyuki Kato, Hiroto Muroi, Maiko Kikuchi, Masakazu Takahashi, Satoru Yamaguchi, Kinro Sasaki, Hitoshi Ishikawa, Hideyuki Sakurai, Hiroyuki Kuwano
BACKGROUND/AIMS: Because salvage surgery after definitive chemoradiotherapy for esophageal cancer is associated with high postoperative mortality and morbidity, minimally invasive methods are desirable. We analyzed the validity of minimally invasive salvage operations (MISO). METHODS: Twenty-five patients underwent salvage operation between 2010 and 2016 in our institution, 10 having undergone right transthoracic salvage esophagectomy (TTSE group), 6 transhiatal salvage esophagectomy (THSE), 6 salvage lymphadenectomy (SLA), and 3 salvage endoscopic submucosal dissection (SESD)...
February 1, 2018: Digestion
Hidekazu Suzuki
In the annual meeting of the Japan Gastroenterological Association (JGA), the scientific organizing committee selected the serial topics for the core symposium. One of the core symposia held during 2015-2017 was entitled "New medical approach to functional dyspepsia (FD)." In 2015, the subtitle of this symposium was "Helicobacter pylori gastritis and FD." In 2016, the subtitle of this symposium was "overlap with other functional GI disorders." In 2017, the subtitle was "therapeutic approach to FD." During these 3 years, a total of 24 presentations were included in Core Symposium 3 and deep and intensive discussions were carried out...
February 1, 2018: Digestion
Koji Yakabi, Kazuhide Higuchi
No abstract text is available yet for this article.
February 1, 2018: Digestion
Yuichi Kojima, Toshihisa Takeuchi, Makoto Sanomura, Ken Higashino, Keishi Kojima, Kenji Fukumoto, Kou Takata, Hiroki Sakamoto, Masahiro Sakaguchi, Kazunari Tominaga, Kazuhide Higuchi
BACKGROUND/AIM: The long-term administration of proton pump inhibitors (PPIs) is useful for preventing recurrent reflux esophagitis. On the other hand, several adverse reactions, such as an increase in the blood gastrin level, have been reported. The aim of the present study was to examine the increase in the blood gastrin level due to the long-term administration of conventional PPIs compared with vonoprazan. METHODS: A prospective cross-sectional study was conducted...
February 1, 2018: Digestion
Yasuaki Nagami, Masaki Ominami, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
BACKGROUND: Adenocarcinoma of the esophagogastric junction (EGJ) is uncommon in Eastern countries, including Japan, but it is believed that the incidence of EGJ adenocarcinoma will increase in Asia in the future due to the decreasing incidence of Helicobacter pylori infection. Endoscopic submucosal dissection (ESD) is a minimally invasive and curative treatment that allows precise pathological assessment. SUMMARY: Magnifying endoscopy with narrow-band imaging may be useful for differential diagnoses and for delineating the cancer margin of EGJ adenocarcinoma, but subsquamous carcinoma extension, which is the invasion of EGJ adenocarcinoma beneath the normal esophageal squamous epithelium, makes it difficult to detect cancer margins of the oral side in ESD for EGJ adenocarcinoma...
February 1, 2018: Digestion
Tomoaki Matsumura, Makoto Arai, Hideaki Ishigami, Mai Fujie, Kentaro Ishikawa, Naoki Akizue, Takashi Taida, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Naoya Kato
BACKGROUND: Impaired esophageal mucosal integrity plays a role in causing symptoms of gastroesophageal reflux disease (GERD). Recently, the assessment of esophageal baseline impedance (BI) using the multichannel intraluminal impedance-pH (MII-pH) test was suggested as a surrogate technique for the study of esophageal mucosal integrity and was reported to be useful in distinguishing GERD from non-GERD. However, measuring BI requires a 24-h testing period, is complicated, and causes considerable patient discomfort...
February 1, 2018: Digestion
Kyoichi Ogata, Akiharu Kimura, Nobuhiro Nakazawa, Masaki Suzuki, Toru Yanoma, Yasunari Ubukata, Kiyohito Iwamatsu, Norimichi Kogure, Mitsuhiro Yanai, Hiroyuki Kuwano
BACKGROUND: Only limited data are available concerning the long-term outcomes of imatinib treatment among Japanese or Asian patients with advanced or recurrent gastrointestinal stromal tumors (GIST). Our multicenter study, which was conducted in northern Kanto, Japan, aimed to assess the efficacy of imatinib mesylate against advanced or recurrent GIST. SUMMARY: The clinicopathological data of 234 GIST patients who were treated at one of the 11 participating hospitals from 2001 to 2011 were retrospectively reviewed (GREAT study)...
February 1, 2018: Digestion
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