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https://www.readbyqxmd.com/read/29719284/characterization-of-helicobacter-pylori-na%C3%A3-ve-early-gastric-cancers
#1
Akihiro Yamada, Mitsuru Kaise, Naoko Inoshita, Takahito Toba, Kosuke Nomura, Yasutaka Kuribayashi, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya
AIM: Helicobacter pylori-naïve gastric cancers(GCs) have not been well documented. We aimed to characterize early H. pylori-naïve GCs. SUBJECTS AND METHODS: Of 666 patients with GC resected by endoscopic submucosal dissection, H. pylori-naïve patients were extracted according to the definition: no H. pylori eradication history, negative for serum H. pylori-antibody and current H. pylori-infection tests, and no gastric atrophy by pepsinogen (PG) test, endoscopy, and histology...
May 2, 2018: Digestion
https://www.readbyqxmd.com/read/29698969/endoscopic-ultrasound-features-of-multiple-endocrine-neoplasia-type-1-related-versus-sporadic-pancreatic-neuroendocrine-tumors-a-single-center-retrospective-study
#2
Gianluca Tamagno, Vanessa Scherer, Alberto Caimo, Simona R Bergmann, Peter H Kann
AIM: Pancreatic neuroendocrine tumors (pNETs) can occur in patients with a familial syndrome either as multiple endocrine neoplasia type 1 (MEN-1) or as sporadic tumors. Endoscopic ultrasound (EUS) has become one of the first-line investigations for pNET characterization. The ultrasonographic features of pNETs may differ depending on the familial versus sporadic pathogenesis of the tumor. Therefore, the EUS findings could help and direct the definition of a pNET with an impact on the most appropriate diagnostic and therapeutic patient management...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698952/combined-systemic-chemotherapy-and-ct-guided-high-dose-rate-brachytherapy-for-isolated-local-manifestation-of-pancreatic-cancer-after-surgical-resection
#3
Caspar Franck, Peter Hass, Peter Malfertheiner, Jens Ricke, Max Seidensticker, Marino Venerito
BACKGROUND: Prospective data on the optimal management of patients with pancreatic ductal adenocarcinoma (PDA) and isolated local manifestation (ILM) after surgery are lacking. Hence, no statements with respect to this entity have been released from most international guidelines including European Society for Medical Oncology, National Comprehensive Cancer Network, and American Society for Clinical Oncology. METHODS: We report for the first time a case-series of 3 patients with PDA and ILM receiving combined systemic chemotherapy and CT-guided high-dose-rate interstitial brachytherapy (CT-HDRBT)...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698951/usefulness-of-fecoflowgram-for-assessment-of-defecation-after-intersphincteric-resection
#4
Hidejiro Kawahara, Takashi Mouri, Kota Ishida, Nori Matsumoto, Tadashi Akiba, Katsuhiko Yanaga
AIM: We have developed an imaging functional assessment of defecation after partial intersphincteric resection (ISR) by fecoflowgram obtained by defecography. PATIENTS AND METHODS: Between January 2012 and December 2014, 6 patients with temporary ileostomy who underwent partial ISR for lower rectal cancer at our hospital were enrolled in this study. Defecography was performed 2 weeks after closure of the ileostomy. The defecation of all patients was evaluated by defecography and a fecoflowgram calculated from defecography...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698945/comparison-of-small-bowel-lesions-using-capsule-endoscopy-in-ulcerative-colitis-and-crohn-s-disease-a-single-center-retrospective-analysis
#5
Kazeo Ninomiya, Takashi Hisabe, Yuki Okado, Yasumichi Takada, Rino Yamaoka, Yuho Sato, Masahiro Kishi, Noritaka Takatsu, Toshiyuki Matsui, Toshiharu Ueki, Kenshi Yao, Fumihito Hirai
BACKGROUND: Capsule endoscopy (CE) has allowed the characterization of small bowel lesions. However, small bowel lesions in ulcerative colitis (UC) have not been elucidated and no studies have compared between UC and Crohn's disease (CD). AIM: The objective of this study was to investigate the small bowel lesions in UC, and to characterize UC lesions by comparison with CD. METHODS: Subjects comprised 54 UC patients and 39 CD patients who underwent CE...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698944/mucosally-expressed-cytokines-are-associated-with-the-esophageal-motility-function
#6
Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, Tsutomu Iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa
BACKGROUND AND AIM: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. METHODS: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. RESULTS: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1)...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698943/the-concentration-of-iodine-in-perigastric-adipose-tissue-a-novel-index-for-the-assessment-of-serosal-invasion-in-patients-with-gastric-cancer-after-neoadjuvant-chemotherapy
#7
Li Yang, Yong Li, Gao-Feng Shi, Tao Zhou, Bi-Bo Tan
OBJECTIVE: This study aims to explore the association between iodine concentration (IC) in perigastric adipose tissue (PAT), quantified by dual-energy computed tomography (DECT) and serosal invasion (SI) in patients with gastric cancer post-neoadjuvant chemotherapy (NAC). METHODS: Forty-three patients with T4-staged gastric cancer were enrolled. IC and standardized IC in PAT (ICPAT and SICPAT) were quantified by DECT pre and post NAC. A postoperative pathologic examination was performed to stage gastric cancer...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698942/diagnostic-accuracy-of-latex-agglutination-turbidimetric-immunoassay-in-screening-adolescents-for-helicobacter-pylori-infection-in-japan
#8
Koshiro Tsutsumi, Chika Kusano, Sho Suzuki, Takuji Gotoda, Kazunari Murakami
BACKGROUND/AIMS: Serologic tests are commonly used for screening Helicobacter pylori infection because they not only provide quick results but also are inexpensive. A new latex agglutination serum antibody assay (LZ test) has been developed and it is expected to be as effective as conventional assays. This study aimed to calculate a reliable cutoff value for the LZ test and to estimate the sensitivity and specificity of the cutoff value in screening adolescents for H. pylori infection in Japan...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29698940/corticosteroid-therapy-improves-the-outcome-of-autoimmune-hepatitis-induced-acute-liver-failure
#9
Olympia E Anastasiou, Betül Dogan-Cavus, Ozlem Kucukoglu, Hideo Baba, Alisan Kahraman, Guido Gerken, Christoph Schramm, Ali Canbay
BACKGROUND/AIMS: Autoimmune hepatitis (AIH) is a relatively rare cause of liver dysfunction and may lead in some cases to acute liver failure (ALF). The aim of our study was to evaluate the clinical course and outcome of patients with AIH-induced ALF. METHODS: We retrospectively enrolled 32 patients with AIH-induced ALF and 93 age- and sex-matched patients with chronic AIH (cAIH) who were enrolled at the University Clinic Essen from 1988 to 2014. All ALF patients were treated with corticosteroids after diagnosis...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29672309/a-web-based-education-program-for-colorectal-lesion-diagnosis-with-narrow-band-imaging-classification
#10
Hiroyuki Aihara, Nitin Kumar, Christopher C Thompson
BACKGROUND: An education system for narrow band imaging (NBI) interpretation requires sufficient exposure to key features. However, access to didactic lectures by experienced teachers is limited in the United States. AIM: To develop and assess the effectiveness of a colorectal lesion identification tutorial. METHODS: In the image analysis pretest, subjects including 9 experts and 8 trainees interpreted 50 white light (WL) and 50 NBI images of colorectal lesions...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672308/modulation-of-pacemaker-potentials-in-murine-small-intestinal-interstitial-cells-of-cajal-by-gamisoyo-san-a-traditional-chinese-herbal-medicine
#11
Doeun Kim, Jung Nam Kim, Joo Hyun Nam, Jong Rok Lee, Sang Chan Kim, Byung Joo Kim
BACKGROUND: The Gamisoyo-san (GSS) has been used for -improving the gastrointestinal (GI) symptoms. The purpose of this study was to investigate the effects of GSS, a traditional Chinese herbal medicine, on the pacemaker potentials of mouse small intestinal interstitial cells of Cajal (ICCs). METHODS: ICCs from the small intestines were dissociated and cultured. Whole-cell patch-clamp configuration was used to record pacemaker potentials and membrane currents. RESULTS: GSS depolarized ICC pacemaker potentials in a dose-dependent manner...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672302/mucosal-two-step-pathogenesis-in-gastroesophageal-reflux-disease-repeated-weakly-acidic-stimulation-and-activation-of-protease-activated-receptor-2-on-mucosal-interleukin-8-secretion
#12
Lukas Winkelsett, Peter Malfertheiner, Thomas Wex, Arne Kandulski
BACKGROUND: Activation of protease-activated receptor-2 (PAR2) is involved in the mucosal immune pathogenesis of gastroesophageal reflux disease (GERD) that is characterized by proinflammatory cytokines such as interleukin-8 (IL-8). PAR2 activation on epithelial cells induces epithelial IL-8 secretion and initiates mucosal inflammation. METHODS: A human primary esophageal epithelial cell model was established to investigate the effects of repeated stimulation with weakly acidic solutions and subsequent PAR2 activation...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672300/clinical-significance-of-reddish-depressed-lesions-observed-in-the-gastric-mucosa-after-helicobacter-pylori-eradication
#13
Takahiro Kotachi, Masanori Ito, Tomoyuki Boda, Mariko Kiso, Kazuhiko Masuda, Kosaku Hata, Toru Kawamura, Yoji Sanomura, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METHODS: We enrolled 301 consecutive patients with H. pylori eradication who underwent endoscopy using white light imaging (WLI). We examined the prevalence and host factors contributing to the presence of RDLs...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672296/predictive-factors-of-portal-hypertensive-enteropathy-exacerbation-in-patients-with-liver-cirrhosis-a-capsule-endoscopy-study
#14
Sayoko Kunihara, Shiro Oka, Shinji Tanaka, Ichiro Otani, Atsushi Igawa, Yuko Nagaoki, Hiroshi Aikata, Kazuaki Chayama
BACKGROUND/AIMS: The clinical course and exacerbation of portal hypertensive enteropathy (PHE) are yet to be fully clarified. This study aimed to identify factors related to PHE exacerbation in patients with liver cirrhosis (LC). METHODS: Fifty patients with LC (33 male; mean age, 67 years), who underwent capsule endoscopy (CE) at the Hiroshima University Hospital between February 2009 and September 2015, were followed up for >6 months. Exacerbation is defined as the appearance of new lesions or worsening of existing lesions...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672294/endoscopic-ultrasound-guided-choledocho-enterostomy-by-using-lumen-apposing-metal-stent-in-patients-with-failed-endoscopic-retrograde-cholangiopancreatography-a-literature-review
#15
Deepanshu Jain, Manan Shah, Upen Patel, Abhinav Sharma, Shashideep Singhal
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) has been the cornerstone in the management of malignant jaundice to provide symptomatic relief and/or to allow chemotherapy. Difficult biliary cannulation or the presence of concomitant duodenal obstruction may lead to its failure. METHOD: An extensive English literature search was done via PubMed and Google Scholar to identify 13 peer-reviewed original articles. RESULTS: Of 92 patients, 98...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672291/initial-management-of-colonic-diverticular-bleeding-observational-study
#16
Michiko Wada, Motohiko Kato, Yuichiro Hirai, Yoko Kubosawa, Yukie Sunata, Keiichiro Abe, Tetsu Hirata, Yoshiaki Takada, Shigeo Banno, Yusaku Takatori, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Miho Kikuchi, Masahiro Kikuchi, Masayuki Suzuki, Takanori Kanai, Toshio Uraoka
BACKGROUND/AIMS: Although colonic diverticular bleeding (CDB) often ceases spontaneously, re-bleeding occurs in about 30%. Bleeding diverticulum can be treated directly by endoscopic hemostasis; however, it is difficult to perform colonoscopy in all cases with limited medical resource and certain risks. The aim of this study was to clarify who should undergo colonoscopy as well as appropriate methods of initial management in CDB patients. METHODS: A total of 285 patients who were diagnosed as CDB and underwent colonoscopy from March 2004 to October 2015 were retrospectively analyzed...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672285/long-term-outcome-of-endoscopic-balloon-dilatation-for-strictures-in-patients-with-crohn-s-disease
#17
Takashi Taida, Tomoo Nakagawa, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Makoto Arai, Tatsuro Katsuno, Naoya Kato
BACKGROUND/AIMS: Endoscopic balloon dilatation (EBD) is an alternative to surgery for strictures in patients with Crohn's disease (CD). The aim of the present study was to clarify the efficacy and safety of EBD for strictures in patients with CD. METHODS: Twenty-six patients with CD who underwent EBD for strictures from August 2008 to November 2015 were followed up after dilatation. Short-term success was defined as the disappearance of obstructive symptoms after technically adequate dilatation was achieved...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29587295/helicobacter-pylori-eradication-therapy-ameliorates-latent-digestive-symptoms-in-chronic-atrophic-gastritis
#18
Shinya Yamada, Naoya Tomatsuri, Takumi Kawakami, Yoshikazu Nakatsugawa, Takeshi Nishimura, Hideki Fujii, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida
BACKGROUND/AIMS: This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis. METHODS: We enrolled 650 health checkup patients who underwent eradication therapy for chronic gastritis and completed a self-report questionnaire before and after the treatment between January 2014 and December 2016 at the Japanese Red Cross Society Kyoto Daiichi Hospital. RESULTS: H. pylori eradication therapy for chronic atrophic gastritis improved latent digestive symptoms, including both the acid reflux and dyspepsia components in the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) scores...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29587290/chemoprevention-and-treatment-of-pancreatic-cancer-update-and-review-of-the-literature
#19
Julia Benzel, Volker Fendrich
BACKGROUND: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29587283/old-and-new-gut-hormone-gastrin-and-acid-suppressive-therapy
#20
Ken Haruma, Tomoari Kamada, Noriaki Manabe, Mitsuhiko Suehiro, Hirofumi Kawamoto, Akiko Shiotani
Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years...
March 27, 2018: Digestion
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