Takaaki Ito, Shinji Kudoh, Kosuke Fujino, Mune Sanada, Yuki Tenjin, Haruki Saito, Yuko Nakaishi-Fukuchi, Hiroki Kameyama, Takaya Ichimura, Naoko Udaka, Noritaka Kudo, Akira Matsuo, Younosuke Sato
Neuroendocrine (NE) differentiation has been histochemically detected in normal and cancer tissues and cells. Immunohistochemical analyses have provided a more detailed understanding of NE biology and pathology. Pulmonary NE cells are a rare lung epithelial type, and small cell carcinoma of the lung (SCLC) is a high-grade NE tumor. Pulmonary NE and SCLC cells share common mechanisms for NE differentiation. Neural or NE cell lineage-specific transcription factors, such as achaete-scute homologue 1 (Ascl1) and insulinoma-associated protein 1 (INSM1), are crucial for the development of pulmonary NE cells, and NE differentiation is influenced by the balance between Ascl1 and the suppressive neural transcription factor, hairy-enhancer of split 1, a representative target molecule of the Notch signaling pathway...
June 29, 2022: Acta Histochemica et Cytochemica