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Chemotherapy

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https://www.readbyqxmd.com/read/30145590/no-therapeutic-effect-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-retreatment-despite-t790m-disappearance-case-report-of-3-cases
#1
Tatsuya Kodama, Keisuke Watanabe, Masaharu Shinkai, Takeshi Kaneko
BACKGROUND: T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT: We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance. T790M mutations were detected in the pleural effusions after the tumors had acquired EGFR-TKI resistance. T790M mutations disappeared from cancer cells in the pleural effusion after a break from the treatment drug and cytotoxic agent administration...
August 24, 2018: Chemotherapy
https://www.readbyqxmd.com/read/30125887/nos3-895g-t-and-cbr3-730g-a-are-associated-with-recurrence-risk-in-non-muscle-invasive-bladder-cancer-with-intravesical-instillations-of-thp
#2
Qidong Zhou, Weihong Ding, Yingjie Weng, Guanxiong Ding, Guowei Xia, Jianfeng Xu, Ke Xu, Qiang Ding
OBJECTIVES: To analyze the correlation between pharmacogenomic biomarkers and the efficacy of pirarubicin (THP, also named 4'-O-tetrahydropyranyl-adriamycin) and to explore potential associations of individual genetic backgrounds with the clinical outcomes of non-muscle-invasive bladder cancer (NMIBC) patients. METHODS: Between July 2003 and June 2011, a total of 91 patients were treated with transurethral resection (TUR) of the bladder tumor and were histopathologically confirmed to have NMIBC...
August 17, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29694973/sustained-erythroid-response-in-a-patient-with-myelofibrosis-receiving-concomitant-treatment-with-ruxolitinib-and-deferasirox
#3
Eugenio Piro, Maria Lentini, Luciano Levato, Antonio Russo, Stefano Molica
Iron overload (IOL) due to transfusion-dependent anemia is a serious adverse effect in patients with myelofibrosis (MF). Recent studies have shown that the oral iron chelator deferasirox may prevent multiple organ damage due to IOL in MF. However, it is not clear whether deferasirox may contribute to revert transfusion-dependent anemia. Here, we present a patient with transfusion-dependent intermediate-2 MF according to the International Prognostic Scoring System treated with ruxolitinib in combination with deferasirox...
April 25, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29672292/identification-of-risk-factors-in-high-dose-methotrexate-induced-acute-kidney-injury-in-childhood-acute-lymphoblastic-leukemia
#4
Dao-Hai Cheng, Hua Lu, Tao-Tao Liu, Xiao-Qin Zou, Hui-Mei Pang
AIMS: Although high-dose methotrexate (HDMTX) is an effective means for the treatment of acute lymphoblastic leukemia (ALL), the development of renal dysfunction remains a significant management challenge. This study aimed to identify the key factors in HDMTX-induced acute kidney injury (AKI) in childhood ALL. METHODS: We retrospectively analyzed the clinical data in 1,329 courses of HDMTX treatment in 336 Chinese ALL children at the First Affiliated Hospital of Guangxi Medical University from September 2012 to November 2016...
April 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29649816/in-vitro-antichlamydial-activity-of-1-2-3-5-tetrasubstituted-pyrrole-derivatives
#5
Hongzhang Ji, Changyue Wu, Min Ni, Nannan Feng, Chan Wang, Yu Zhao, Lingyan Liu, Shengju Yang, Xiaofeng Bao
BACKGROUND: Chlamydia is a group of bacterial pathogens distributed worldwide that can lead to serious reproductive and other health problems. The rise of antibiotic-resistant pathogens promotes the development of novel antichlamydial agents. The aim of this study is to assess in vitro antichlamydial activity of our previously synthesized 1,2,3,5- tetrasubstituted pyrroles. METHODS: The derivatives were screened for their antichlamydial activity against three Chlamydia strains by calculating IC50 values using concentration-response inhibition data between 1 and 32 μM...
April 12, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29621772/a-complete-pathological-response-to-pembrolizumab-following-ex-vivo-liver-resection-in-a-patient-with-colorectal-liver-metastases
#6
Maria Baimas-George, Erin Baker, Michal Kamionek, J Stuart Salmon, Amit Sastry, David Levi, Dionisios Vrochides
Advances in the systemic treatment of stage IV colorectal cancer with liver metastases has offered improved survival rates for patients who otherwise face a dismal prognosis. However, a pathologically complete response (PCR) to chemotherapy for colorectal liver metastases is still rare, and its significance is not fully understood. In this case report, we describe a patient who achieved PCR after neoadjuvant immunotherapy with pembrolizumab and a left hepatectomy using an ex vivo resection technique.
April 5, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29554654/radiotherapy-and-vascular-endothelial-growth-factor-receptor-tyrosine-kinase-inhibitors-in-renal-cancer
#7
Michele Fiore, Rolando Maria D Apos Angelillo, Carlo Greco, Iacopo Fioroni, Edy Ippolito, Daniele Santini, Sara Ramella
Treatment of metastatic renal cell carcinoma (mRCC) has seen substantial progress over the last decade. A number of targeted therapies have been shown to improve clinical outcome. Vascular endothelial growth factor receptor (VEGFR)-tyrosine kinase inhibitors (TKIs) are an effective option in treating mRCC. RCC is traditionally perceived to be a radioresistant malignancy with a limited role of radiotherapy (RT) in the management of localized disease. While RCC appears to be radioresistant using conventionally fractionated RT, preclinical data suggest increased radiosensitivity when an ablative, hypofractionated schedule is used...
March 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29554652/efficacy-of-a-propolis-based-syrup-faringel-in-preventing-radiation-induced-esophagitis-in-locally-advanced-lung-cancer
#8
Edy Ippolito, Barnaba Floreno, Carla Germana Rinaldi, Lucio Trodella, Federica Loretta Meroni, Aurelia Iurato, Rolando Maria D'Angelillo, Sara Ramella, Michele Fiore
AIM: To evaluate the efficacy of a propolis-based syrup, FARINGEL®, in preventing radiation-induced esophagitis in locally advanced lung cancer patients. METHODS: Patients were treated with concurrent chemoradiotherapy (CRT) using involved-field radiotherapy (RT). Every patient received FARINGEL at the beginning of CRT until the first follow-up. The data of the study group were compared with the data of a control group treated without the administration of the syrup...
March 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29533947/beneficial-and-detrimental-effects-of-antiretroviral-therapy-on-hiv-associated-immunosenescence
#9
Ornella Franzese, Maria Luisa Barbaccia, Enzo Bonmassar, Grazia Graziani
Since the introduction of highly active antiretroviral therapy more than 2 decades ago, HIV-related deaths have dramatically decreased and HIV infection has become a chronic disease. Due to the inability of antiretroviral drugs to eradicate the virus, treatment of HIV infection requires a systemic lifelong therapy. However, even when successfully treated, HIV patients still show increased incidence of age-associated co-morbidities compared with uninfected individuals. Virus- induced immunosenescence, a process characterized by a progressive decline of immune system function, contributes to the premature ageing observed in HIV patients...
March 13, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29428941/editorial-the-journal-chemotherapy-is-for-cardio-oncologists-too
#10
Giorgio Minotti
No abstract text is available yet for this article.
February 9, 2018: Chemotherapy
https://www.readbyqxmd.com/read/30107372/clinical-impact-of-post-progression-survival-on-overall-survival-in-elderly-patients-with-non-small-cell-lung-cancer-harboring-sensitive-egfr-mutations-treated-with-first-line-egfr-tyrosine-kinase-inhibitors
#11
Hisao Imai, Yutaka Yamada, Tomohide Sugiyama, Hiroyuki Minemura, Kyoichi Kaira, Kenya Kanazawa, Takashi Kasai, Takayuki Kaburagi, Koichi Minato
BACKGROUND/AIMS: More than 50% of patients with lung cancer are aged > 65 years, and non-small-cell lung cancer (NSCLC) accounts for 85% of all cases of lung cancer among both elderly and adult patients. Subsequent therapies confound the capability to discern the effect of first-line chemotherapy on overall survival (OS). Therefore, using individual-level data, our study aimed to determine the relationships of progression-free survival (PFS) and post-progression survival (PPS) with OS after first-line epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment in elderly patients with NSCLC harboring sensitive EGFR mutations...
2018: Chemotherapy
https://www.readbyqxmd.com/read/30032143/host-directed-therapies-for-tuberculosis-futures-strategies-for-an-ancient-disease
#12
REVIEW
Ivana Palucci, Giovanni Delogu
The emergence and spread of drug-resistant strains of Mycobacterium tuberculosis is worsening the global threat of tuberculosis (TB). There is a need and urgency for the development of new treatments for TB, for the management of drug resistant TB (MDR-TB) and for improved regimens against drug-susceptible TB, with the goal of reducing toxicity and length of therapy that will boost patience compliance. The paucity of new drugs is a major obstacle to design new regimens while host-directed therapies (HDTs) are emerging as a promising area of research and are opening new avenues to fight TB...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29969754/specifications-of-computerized-provider-order-entry-and-clinical-decision-support-systems-for-cancer-patients-undergoing-chemotherapy-a-systematic-review
#13
REVIEW
Rezvan Rahimi, Alireza Kazemi, Hamid Moghaddasi, Khadijeh Arjmandi Rafsanjani, Gholamreza Bahoush
OBJECTIVE: Chemotherapy medication errors are catastrophic. The prescription phase in the chemotherapy process plays a key role in the creation of medication errors, and therefore the use of computerized physician order entry (CPOE) and clinical decision support system (CDS) systems is recommended to reduce chemotherapy medication errors. The purpose of this study was to carry out a systematic review on the specifications of the CPOE and CDS systems for chemotherapy prescription. MATERIALS AND METHODS: A systematic review on articles published in English up to September 22, 2017, using the 3 databases PubMed, Embase, and Medline was conducted...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29936511/isoliquiritigenin-suppresses-osteosarcoma-u2os-cell-proliferation-and-invasion-by-regulating-the-pi3k-akt-signalling-pathway
#14
Jing Chen, Cheng Liu, Qin-Qing Yang, Rui-Bin Ma, Ying Ke, Fang Dong, Xiao-E Wu
AIMS: Isoliquiritigenin (ISL) is a flavonoid, that has been shown to have antioxidant, vasorelaxant, anti-inflammatory, and antitumor activities. This study aimed to explore the antitumor effect of ISL on human osteosarcoma U2OS cells and investigate the mechanism of this effect. METHODS: The effect of ISL on osteosarcoma U2OS cell proliferation, invasion, migration, and apoptosis were determined by a CCK8 assay, a transwell invasion assay, a transwell migration assay, and fluorescence-activated cell sorting, respectively...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29902788/genetic-diversity-of-mycobacterium-tuberculosis-isolates-in-the-metropolitan-area-of-rome
#15
Angela Cannas, Serena Camassa, Michela Sali, Ornella Butera, Antonio Mazzarelli, Maurizio Sanguinetti, Antonino Di Caro, Giovanni Delogu, Enrico Girardi
BACKGROUND: The presence in a geographic area of Mycobacterium tuberculosis (Mtb) strains belonging to different phylogeographic lineages and showing different drug susceptibility patterns may suggest recent transmission, with implications in terms of patient clinical management and disease control. The aim of this study was to carry out a preliminary epidemiological investigation of tuberculosis (TB) cases in Rome. METHODS: A total of 232 Mtb isolates, collected from new or previously treated patients, admitted between 2008 and 2014 at 2 hospital settings in Rome with a diagnosis of TB, were analyzed by spoligotyping and analyzing 24 variable-number tandem repeats (VNTR) mycobacterial interspersed repetitive-unit (MIRU) loci...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29898438/current-opinion-and-knowledge-on-peritoneal-carcinomatosis-a-survey-among-a-swiss-oncology-network
#16
Fabian Grass, David Martin, Michael Montemurro, Patrice Mathevet, Anita Wolfer, George Coukos, Nicolas Demartines, Martin Hübner
AIMS OF THE STUDY: The present survey aimed to evaluate current opinion and practice regarding peritoneal metastasis (PM), satisfaction with available treatment options, and need for new therapeutic approaches. METHODS: This was a qualitative study conducted between October 2016 and October 2017 in the Réseau Suisse Romand d'Oncologie including 101 members of various oncological specialties. Participants' demographics, current practice, knowledge, and satisfaction regarding available treatment options and need for new treatment options were assessed by semantic differential scales through 33 closed questions with automatic reminders at 4-, 8-, 12-, and 16-week intervals...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29768260/carboplatin-dosing-accuracy-by-estimation-of-glomerular-filtration-versus-creatinuria-in-cancer-patients
#17
Noiver Graciano Vera, Luis Pino Villarreal, Jenny Ureña Vargas
BACKGROUND: The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula with the best performance. METHODS: Patients admitted between 2011 and 2017 and diagnosed with ovarian, endometrial, lung, esophageal, or testicular cancer were assessed retrospectively...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29649826/erratum
#18
(no author information available yet)
In the abstract of the article by V. Calabrese et al. entitled “Early Diastolic Dysfunction after Cancer Chemotherapy: Primary Endpoint Results of a Multicenter Cardio-Oncology Study” [Chemotherapy 2018; 63: 55–63, DOI: 10.1159/000486761], the sixth sentence should read: “Eighty patients (68 females, 12 males, median age 49 years) were evaluated at 1 week after chemotherapy (T1).”
2018: Chemotherapy
https://www.readbyqxmd.com/read/29428939/early-diastolic-dysfunction-after-cancer-chemotherapy-primary-endpoint-results-of-a-multicenter-cardio-oncology-study
#19
MULTICENTER STUDY
Vito Calabrese, Pierantonio Menna, Ombretta Annibali, Grazia Armento, Armando Carpino, Elisabetta Cerchiara, Carlo Greco, Francesco Marchesi, Paolo Spallarossa, Giuseppe Toglia, Giorgio Reggiardo, Giorgio Minotti
Asymptomatic diastolic dysfunction (DD) with preserved left ventricular ejection fraction (LVEF) is suspected to precede late cardiac events in cancer survivors treated by chemotherapy. We conducted the first multicenter study of early DD induced by chemotherapy. Patients who were candidates for standard dose chemotherapy were screened for the absence of cardiovascular risk factors, LVEF ≥50%, normal-for-age diastolic function at echocardiography (E/A ratio, E wave deceleration time; DT), normal levels of potential DD biomarkers like Nt-proBNP (≤125 pg/mL), and cardiac troponin I (cTnI, ≤0...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29393107/pazopanib-induced-hepatotoxicity-in-an-experimental-rat-model
#20
Bulent Cetin, Guldal Esendagli Yılmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Ozlem Gulbahar, Ozge Gumusay, Irem Bilgetekin, Ahmet Ozet, Aytug Uner
Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an experimental rat model. Sixteen Wistar albino rats were divided into 3 groups: experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water...
2018: Chemotherapy
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