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Chemotherapy

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https://www.readbyqxmd.com/read/29768260/carboplatin-dosing-accuracy-by-estimation-of-glomerular-filtration-versus-creatinuria-in-cancer-patients
#1
Noiver Graciano Vera, Luis Pino Villarreal, Jenny Ureña Vargas
BACKGROUND: The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula with the best performance. METHODS: Patients admitted between 2011 and 2017 and diagnosed with ovarian, endometrial, lung, esophageal, or testicular cancer were assessed retrospectively...
May 16, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29694973/sustained-erythroid-response-in-a-patient-with-myelofibrosis-receiving-concomitant-treatment-with-ruxolitinib-and-deferasirox
#2
Eugenio Piro, Maria Lentini, Luciano Levato, Antonio Russo, Stefano Molica
Iron overload (IOL) due to transfusion-dependent anemia is a serious adverse effect in patients with myelofibrosis (MF). Recent studies have shown that the oral iron chelator deferasirox may prevent multiple organ damage due to IOL in MF. However, it is not clear whether deferasirox may contribute to revert transfusion-dependent anemia. Here, we present a patient with transfusion-dependent intermediate-2 MF according to the International Prognostic Scoring System treated with ruxolitinib in combination with deferasirox...
April 25, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29672292/identification-of-risk-factors-in-high-dose-methotrexate-induced-acute-kidney-injury-in-childhood-acute-lymphoblastic-leukemia
#3
Dao-Hai Cheng, Hua Lu, Tao-Tao Liu, Xiao-Qin Zou, Hui-Mei Pang
AIMS: Although high-dose methotrexate (HDMTX) is an effective means for the treatment of acute lymphoblastic leukemia (ALL), the development of renal dysfunction remains a significant management challenge. This study aimed to identify the key factors in HDMTX-induced acute kidney injury (AKI) in childhood ALL. METHODS: We retrospectively analyzed the clinical data in 1,329 courses of HDMTX treatment in 336 Chinese ALL children at the First Affiliated Hospital of Guangxi Medical University from September 2012 to November 2016...
April 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29649816/in-vitro-antichlamydial-activity-of-1-2-3-5-tetrasubstituted-pyrrole-derivatives
#4
Hongzhang Ji, Changyue Wu, Min Ni, Nannan Feng, Chan Wang, Yu Zhao, Lingyan Liu, Shengju Yang, Xiaofeng Bao
BACKGROUND: Chlamydia is a group of bacterial pathogens distributed worldwide that can lead to serious reproductive and other health problems. The rise of antibiotic-resistant pathogens promotes the development of novel antichlamydial agents. The aim of this study is to assess in vitro antichlamydial activity of our previously synthesized 1,2,3,5- tetrasubstituted pyrroles. METHODS: The derivatives were screened for their antichlamydial activity against three Chlamydia strains by calculating IC50 values using concentration-response inhibition data between 1 and 32 μM...
April 12, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29649826/erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
April 10, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29621772/a-complete-pathological-response-to-pembrolizumab-following-ex-vivo-liver-resection-in-a-patient-with-colorectal-liver-metastases
#6
Maria Baimas-George, Erin Baker, Michal Kamionek, J Stuart Salmon, Amit Sastry, David Levi, Dionisios Vrochides
Advances in the systemic treatment of stage IV colorectal cancer with liver metastases has offered improved survival rates for patients who otherwise face a dismal prognosis. However, a pathologically complete response (PCR) to chemotherapy for colorectal liver metastases is still rare, and its significance is not fully understood. In this case report, we describe a patient who achieved PCR after neoadjuvant immunotherapy with pembrolizumab and a left hepatectomy using an ex vivo resection technique.
April 5, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29554654/radiotherapy-and-vascular-endothelial-growth-factor-receptor-tyrosine-kinase-inhibitors-in-renal-cancer
#7
Michele Fiore, Rolando Maria D Apos Angelillo, Carlo Greco, Iacopo Fioroni, Edy Ippolito, Daniele Santini, Sara Ramella
Treatment of metastatic renal cell carcinoma (mRCC) has seen substantial progress over the last decade. A number of targeted therapies have been shown to improve clinical outcome. Vascular endothelial growth factor receptor (VEGFR)-tyrosine kinase inhibitors (TKIs) are an effective option in treating mRCC. RCC is traditionally perceived to be a radioresistant malignancy with a limited role of radiotherapy (RT) in the management of localized disease. While RCC appears to be radioresistant using conventionally fractionated RT, preclinical data suggest increased radiosensitivity when an ablative, hypofractionated schedule is used...
March 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29554652/efficacy-of-a-propolis-based-syrup-faringel-in-preventing-radiation-induced-esophagitis-in-locally-advanced-lung-cancer
#8
Edy Ippolito, Barnaba Floreno, Carla Germana Rinaldi, Lucio Trodella, Federica Loretta Meroni, Aurelia Iurato, Rolando Maria D'Angelillo, Sara Ramella, Michele Fiore
AIM: To evaluate the efficacy of a propolis-based syrup, FARINGEL®, in preventing radiation-induced esophagitis in locally advanced lung cancer patients. METHODS: Patients were treated with concurrent chemoradiotherapy (CRT) using involved-field radiotherapy (RT). Every patient received FARINGEL at the beginning of CRT until the first follow-up. The data of the study group were compared with the data of a control group treated without the administration of the syrup...
March 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29533947/beneficial-and-detrimental-effects-of-antiretroviral-therapy-on-hiv-associated-immunosenescence
#9
Ornella Franzese, Maria Luisa Barbaccia, Enzo Bonmassar, Grazia Graziani
Since the introduction of highly active antiretroviral therapy more than 2 decades ago, HIV-related deaths have dramatically decreased and HIV infection has become a chronic disease. Due to the inability of antiretroviral drugs to eradicate the virus, treatment of HIV infection requires a systemic lifelong therapy. However, even when successfully treated, HIV patients still show increased incidence of age-associated co-morbidities compared with uninfected individuals. Virus- induced immunosenescence, a process characterized by a progressive decline of immune system function, contributes to the premature ageing observed in HIV patients...
March 13, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29428941/editorial-the-journal-chemotherapy-is-for-cardio-oncologists-too
#10
Giorgio Minotti
No abstract text is available yet for this article.
February 9, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29428939/early-diastolic-dysfunction-after-cancer-chemotherapy-primary-endpoint-results-of-a-multicenter-cardio-oncology-study
#11
Vito Calabrese, Pierantonio Menna, Ombretta Annibali, Grazia Armento, Armando Carpino, Elisabetta Cerchiara, Carlo Greco, Francesco Marchesi, Paolo Spallarossa, Giuseppe Toglia, Giorgio Reggiardo, Giorgio Minotti
Asymptomatic diastolic dysfunction (DD) with preserved left ventricular ejection fraction (LVEF) is suspected to precede late cardiac events in cancer survivors treated by chemotherapy. We conducted the first multicenter study of early DD induced by chemotherapy. Patients who were candidates for standard dose chemotherapy were screened for the absence of cardiovascular risk factors, LVEF ≥50%, normal-for-age diastolic function at echocardiography (E/A ratio, E wave deceleration time; DT), normal levels of potential DD biomarkers like Nt-proBNP (≤125 pg/mL), and cardiac troponin I (cTnI, ≤0...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29393107/pazopanib-induced-hepatotoxicity-in-an-experimental-rat-model
#12
Bulent Cetin, Guldal Esendagli Yılmaz, Berkan Armagan, Baris Afsar, Umut Demirci, Ozlem Gulbahar, Ozge Gumusay, Irem Bilgetekin, Ahmet Ozet, Aytug Uner
Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. The aim of the present study was to evaluate the effect of pazopanib on the liver in an experimental rat model. Sixteen Wistar albino rats were divided into 3 groups: experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29393100/antitumor-efficacy-of-combination-therapy-consisting-of-s-1-leucovorin-and-oxaliplatin-against-human-gastric-cancer-xenografts
#13
Hideki Nagase, Fumio Nakagawa, Junji Uchida
BACKGROUND/AIM: A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and oxaliplatin against 4 human gastric cancer xenografts: NUGC-4, St-40, SC-2, and SC-4. METHODS: The antitumor efficacy was evaluated using human gastric cancer xenograft-bearing nude mice...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29334366/modified-colistin-regimen-for-critically-ill-patients-with-acute-renal-impairment-and-continuous-renal-replacement-therapy
#14
Pierantonio Menna, Emanuela Salvatorelli, Alessia Mattei, Dario Cappiello, Giorgio Minotti, Massimiliano Carassiti
Colistin is a last resort antibiotic to treat multidrug-resistant Gram-negative bacteria infections. Colistin is administered intravenously in the form of its inactive prodrug colistin methanesulfonate (CMS). For patients with acute kidney impairment and continuous renal replacement therapy high extracorporeal clearance may cause a substantial removal of active colistin from the bloodstream, eventually decreasing its antibacterial efficacy. Currently recommended doses of CMS may therefore be inadequate for these patients...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29169153/optimal-trough-concentration-of-teicoplanin-in-febrile-neutropenic-patients-with-hematological-malignancy
#15
Yuhki Sato, Kazufumi Hiramatsu, Yosuke Suzuki, Ryota Tanaka, Tetsuya Kaneko, Ko Nonoshita, Masao Ogata, Jun-Ichi Kadota, Hiroki Itoh
BACKGROUND: Teicoplanin is a glycopeptide antibiotic currently used for the treatment of methicillin-resistant Staphylococcus aureus. The need for therapeutic drug monitoring of teicoplanin has been increasingly highlighted as important. It is generally accepted that whereas a plasma trough concentration (Cmin) of ≥10 mg/L is appropriate for the majority of infections, it should exceed 20 mg/L for severe infections. The target Cmin of teicoplanin in patients with febrile neutropenia (FN) has not been reported...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29145175/antimicrobial-activity-of-galangin-and-its-effects-on-murein-hydrolases-of-vancomycin-intermediate-staphylococcus-aureus-visa-strain-mu50
#16
Jing Ouyang, Fengjun Sun, Wei Feng, Yonghong Xie, Lijuan Ren, Yongchuan Chen
Backgroud: Antibiotic treatment for infections caused by vancomycin-intermediate Staphylococcus aureus (VISA) strains is challenging, and only a few effective and curative methods have been developed to combat these strains. This study aimed to investigate the antimicrobial activity of galangin against S. aureus and its effects on the murein hydrolases of VISA strain Mu50. This is the first report on these effects of galangin, and it may help to improve the treatment for VISA infections by demonstrating the effective use of galangin...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29130946/considerations-about-the-use-of-a-loading-dose-of-daptomycin-in-a-neutropenic-murine-thigh-infection-model-with-methicillin-resistant-staphylococcus-aureus-infection
#17
Hideo Kato, Mao Hagihara, Eriko Murakami, Hiroyuki Suematsu, Naoya Nishiyama, Yusuke Koizumi, Yuka Yamagishi, Bunji Uno, Hiroshige Mikamo
Previous clinical studies have showed the clinical benefits of the initiation of treatment with a daptomycin (DAP) loading dose, but only a few studies have evaluated its antimicrobial benefits. We evaluated the efficacy of a DAP loading dose against methicillin-resistant Staphylococcus aureus (MRSA) infections in a neutropenic murine thigh infection model. Three MRSA isolates (DAP MIC: 0.5, 1, and 2 mg/L) were tested. Four DAP regimens simulating human concentration-time profiles, i.e., (i) day 1: 8 mg/kg and day 2: 6 mg/kg, (ii) days 1 and 2: 6 mg/kg/day, (iii) day 1: 8 mg/kg and day 2: 4 mg/kg, and (iv) days 1 and 2: 4 mg/kg/day, were administered to the mice...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29130943/effect-of-a-shortened-duration-of-folfox-chemotherapy-on-the-survival-rate-of-patients-with-stage-ii-and-iii-colon-cancer
#18
Woong Bae Ji, Kwang Dae Hong, Jung-Sik Kim, Sung-Yup Joung, Jun Won Um, Byung-Wook Min
BACKGROUND: FOLFOX chemotherapy is widely used as an adjuvant treatment for advanced colon cancer. The duration of adjuvant chemotherapy is usually set to 6 months, which is based on a former study of 5-fluorouracil/leucovorin chemotherapy. However, the FOLFOX regimen is known to have complications, such as peripheral neuropathy. The aim of this study was to compare the survival rates and complications experienced by patients receiving either 4 or 6 months of FOLFOX chemotherapy. METHODS: Retrospective data analysis was performed for stage II and III patients who underwent radical resection of colon cancer...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29069647/%C3%AE-pinene-inhibits-human-prostate-cancer-growth-in-a-mouse-xenograft-model
#19
Yunqi Zhao, Ran Chen, Yun Wang, Yixin Yang
BACKGROUND: α-Pinene is one of the most widely found terpenoids in nature. Substantial evidence shows that α-pinene has cancer prevention properties. In this study, the PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. METHODS: Cytotoxicity was measured with the MTT assay, and apoptosis and cell cycle analyses were conducted using flow cytometry in vitro. The PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice...
2018: Chemotherapy
https://www.readbyqxmd.com/read/29045938/effectiveness-of-nivolumab-versus-docetaxel-as-second-line-treatment-in-non-small-cell-lung-cancer-patients-in-clinical-practice
#20
Pablo Calpe-Armero, Rafael Ferriols-Lisart, Francisco Ferriols-Lisart, Alejandro Pérez-Pitarch
AIMS: To evaluate the effectiveness of nivolumab as second-line treatment compared to standard therapy with docetaxel in adult patients with non-small cell lung cancer (NSCLC) in clinical practice. METHODS: This is an observational, retrospective cohort study of adult patients diagnosed with NSCLC, stage III-IV, treated with docetaxel or nivolumab as second-line treatment. The end points evaluated were overall survival (OS) and progression-free survival (PFS). PFS and OS were described using the Kaplan-Meier method...
2017: Chemotherapy
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