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Acta Haematologica

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https://www.readbyqxmd.com/read/29136618/hepcidin-in-iron-homeostasis-diagnostic-and-therapeutic-implications-in-type-2-diabetes-mellitus-patients
#1
Sintayehu Ambachew, Belete Biadgo
The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin...
November 15, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29136616/no-relapse-of-calcineurin-inhibitor-associated-thrombotic-microangiopathy-after-discontinuation-of-eculizumab
#2
Thomas Neumann, Andrzej Plis, Martin Weigel, Sylvia Stracke, Sigrun Friesecke, Stephanie-Susanne Stecher, Laila Schneidewind, Christoph Busemann, Christian Andreas Schmidt, William H Krüger
No abstract text is available yet for this article.
November 15, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29065396/cd34-cd38-cd123-cells-are-present-in-virtually-all-acute-myeloid-leukaemia-blasts-a-promising-single-unique-phenotype-for-minimal-residual-disease-detection
#3
Adhra Al-Mawali, Avinash Daniel Pinto, Shoaib Al-Zadjali
BACKGROUND/AIMS: In CD34-positive acute myeloid leukaemia (AML), the leukaemia-initiating event likely takes place in the CD34+CD38- cell compartment. CD123 has been shown to be a unique marker of leukaemic stem cells within the CD34+CD38- compartment. The aim of this study was to identify the percentage of CD34+CD38-CD123+ cells in AML blasts, AML CD34+CD38- stem cells, and normal and regenerating bone marrow CD34+CD38- stem cells from non-myeloid malignancies. METHODS: Thirty-eight adult de novo AML patients with intention to treat were enrolled after the application of inclusion criteria from February 2012 to February 2017...
October 25, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29045939/very-low-dose-decitabine-is-effective-in-treating-intermediate-or-high-risk-myelodysplastic-syndrome
#4
Hongmin Li, Liru Wang, Yue Wu, Li Su, Hong Zhao, Yongqing Zhang, Zhao Wang, Dayong Huang, Zhongxia Huang, Xiaoxiong Wu, Xiaohong Li, Fang Ye, Fan Yu, Hui Liu, Jing-Wen Wang, Jia Cong, Wanjun Sun, Hui-Ren Chen, Jingbo Wang, Bing Han
Nowadays, the regular recommended dose of decitabine for the treatment of myelodysplastic syndrome (MDS) is 20 mg/m2/day for 5 consecutive days with a relatively high incidence of treatment-related morbidities and costs. In this study, a retrospective and multicenter analysis was performed to explore the very-low-dose decitabine schedule for the treatment of patients with IPSS intermediate- or high-risk MDS. A total of 31 newly diagnosed MDS cases from 14 hospitals in Beijing received decitabine monotherapy (decitabine 6 mg/m2/day intravenously for 7 consecutive days, repeated every 4 weeks)...
October 19, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28992618/pregnancy-outcome-among-women-with-beta-thalassemia-major-in-north-sardinia
#5
Claudio Fozza, Maria Antonietta Asara, Nadia Vacca, Sara Caggiari, Anna Monti, Francesca Zaccheddu, Giampiero Capobianco, Salvatore Dessole, Fausto Dore, Roberto Antonucci
No abstract text is available yet for this article.
October 10, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28982102/reticulocytes-are-an-enriched-source-of-the-ruvbl1-protein
#6
Beverly W Baron, Rebecca M Baron, Joseph M Baron
No abstract text is available yet for this article.
October 6, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28972944/delayed-development-of-hemolytic-anemia-with-fragmented-red-blood-cells-and-cardiac-and-renal-impairments-after-high-dose-chemotherapy-and-autologous-hematopoietic-stem-cell-transplantation-for-malignant-lymphoma
#7
Futoshi Iioka, Yusuke Toda, Yuya Nagai, Takashi Akasaka, Daiki Shimomura, Katsuyo Tsuda, Fumihiko Nakamura, Hitoshi Ohno
Among 42 consecutive patients with malignant lymphoma who underwent high-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (AHSCT), 5 developed hemolytic anemia with fragmented red blood cells (HA-FrRBCs) on days 87-125 (median 107) of AHSCT. Nadir Hb levels ranged between 5.0 and 6.4 g/dL with 2.2-5.6% FrRBCs. All patients developed grade ≥3 hypoxia and heart failure, and 4 developed grade ≥3 hypertension. The ejection fraction of the left ventricle assessed by echocardiography was significantly reduced in 3 patients...
October 4, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28873367/idh1-mutation-is-an-independent-inferior-prognostic-indicator-for-patients-with-myelodysplastic-syndromes
#8
Na Wang, Fei Wang, Ningning Shan, Xiaohui Sui, Hongzhi Xu
BACKGROUND: Genomic sequencing technologies have identified isocitrate dehydrogenase (IDH) mutations in haematological malignancies. The prognostic implications of somatic IDH mutation (mIDH) in myelodysplastic syndromes (MDS) remain controversial. METHODS: Mutations in IDH1 and IDH2 were detected using genomic sequencing technologies in 97 patients with MDS. RESULTS: Seven (7.2%) mutations were identified: 3 in IDH1 (all R132C) and 4 in IDH2 (3 R140Q and 1 R140L)...
September 6, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28873366/switching-on-adherence-in-chronic-myeloid-leukemia
#9
Avi Leader, Pia Raanani
No abstract text is available yet for this article.
September 6, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28869927/improved-drug-adherence-in-patients-with-chronic-myeloid-leukemia-in-the-chronic-phase-by-switching-to-second-generation-tyrosine-kinase-inhibitors
#10
Yasuhiro Maeda, Atsushi Okamoto, Shin-Ichiro Kawaguchi, Akiko Konishi, Kenta Yamamoto, Go Eguchi, Yoshitaka Kanai, Terufumi Yamaguchi
No abstract text is available yet for this article.
September 5, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28866671/autoimmune-myelofibrosis-clinical-features-course-and-outcome
#11
Caroline I Piatek, Maria E Vergara-Lluri, Vinod Pullarkat, Imran N Siddiqi, Casey O'Connell, Russell K Brynes, Donald I Feinstein
BACKGROUND: Autoimmune myelofibrosis (AIMF) is an underrecognized cause of nonmalignant bone marrow fibrosis which occurs in the presence or absence of a defined systemic autoimmune disease. Patients with AIMF present with cytopenias and autoantibodies, and have a distinctive nonclonal myelofibrosis on bone marrow examination. AIMF is distinguished from primary myelofibrosis by the absence of splenomegaly, eosinophilia, or basophilia, and the absence of abnormal myeloid, erythroid, or megakaryocytic morphology...
September 2, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28866669/observational-monitoring-of-patients-with-aplastic-anemia-and-low-intermediate-1-risk-of-myelodysplastic-syndromes-complicated-with-iron-overload
#12
Yali Du, Zhangbiao Long, Miao Chen, Bing Han, Bo Hou, Feng Feng
BACKGROUND: This study focuses on the iron overload (IOL) of patients with transfused aplastic anemia (AA) or a low/intermediate-1 risk of myelodysplastic syndrome (MDS). METHODS: Ninety-two AA or MDS patients with IOL were prospectively recruited. Clinical data were collected every 6 months, and organ magnetic resonance imaging T2* values were collected annually. Patients with IOL were chelated. RESULTS: Serum ferritin was correlated with liver T2* and pancreatic T2* in the AA and MDS groups...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28858876/intracranial-hemorrhage-in-patients-newly-diagnosed-with-acute-myeloid-leukemia-and-hyperleukocytosis
#13
Frank Lieberman, Vipin Villgran, Daniel Normolle, Michael Boyiadzis
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28858863/association-of-plasminogen-activator-inhibitor-1-gene-polymorphisms-and-methylene-tetrahydrofolate-reductase-polymorphisms-with-spontaneous-miscarriages
#14
Petra Bubalo, Iva Buterin, Zrinko Šalek, Vesna Ðogić, Silva Zupančić-Šalek
AIM: The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) polymorphisms and unexplained spontaneous miscarriages (SM). MATERIALS AND METHODS: PAI-1 polymorphisms were evaluated in 150 women with pregnancy in their history. One hundred women with a history of SM formed the study group and 50 women with normal pregnancies served as the control group...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28848193/anemia-in-the-elderly-in-northeastern-thailand-a-community-based-study-investigating-prevalence-contributing-factors-and-hematologic-features
#15
Lalitpatch Deeruksa, Kanokwan Sanchaisuriya
This community-based study investigated anemia prevalence and certain hematologic features and their possible relationships to thalassemia and iron deficiency (ID) in a population of older people in Northeastern Thailand. Participants included 319 apparently healthy individuals ranging in age from 60 to 98 years, whose current health status was assessed by means of personal interviews. Blood samples were also collected to determine the following parameters: red blood cell indices, serum ferritin, C-reactive protein, hemoglobin profiles, and the α0-thalassemia gene...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28848082/epinephrine-stimulates-cell-proliferation-and-induces-chemoresistance-in-myeloma-cells-through-the-%C3%AE-adrenoreceptor-in-vitro
#16
Yang Liu, Xiaochen Yu, Junling Zhuang
OBJECTIVES: To explore the effect of the β-adrenoreceptor signaling pathway on myeloma cells. METHODS: The myeloma U266 cell line was treated with epinephrine and propranolol. Cell proliferation was analyzed by MTS assay. Apoptosis was detected by flow cytometry. The β-receptor subtype and the key enzyme of epinephrine were identified by reverse transcription polymerase chain reaction (RT-PCR). RESULTS: Epinephrine (5-50 μM) promoted U266 cell growth in a dose-dependent manner and neutralized the inhibition effect of bortezomib (25 and 50 ng/mL) in vitro...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28817815/arterial-and-venous-thrombosis-in-haemophilia-patients-experiences-from-a-danish-haemophilia-centre
#17
Julie Brogaard Larsen, Karen Bang Jin Nielsen, Lone Hvitfeldt Poulsen, Mustafa Vakur Bor
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28813697/green-inclusions-in-neutrophils-and-monocytes-are-an-indicator-of-acute-liver-injury-and-high-mortality
#18
Nisha Patel, Corey M Hoffman, Bruce I Goldman, Karen Bentley, W Richard Burack, Andrew G Evans
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28797003/pleural-effusion-in-multiple-myeloma-characteristics-and-practice-patterns
#19
Ja Min Byun, Ki Hwan Kim, In Sil Choi, Jin Hyun Park, Jin-Soo Kim, Dong-Yeop Shin, Youngil Koh, Inho Kim, Sung-Soo Yoon, Hyo Jeong Lim
In many Asian countries battling with the double burden of increasing noninfectious diseases on top of infectious diseases, multiple myeloma (MM) patients presenting with pleural effusion (PE) pose a great diagnostic challenge. Thus, we aimed to analyze the clinical features and practice patterns of such patients. This is a multicenter retrospective study of newly diagnosed MM patients between January 2011 and December 2015. Among 575 MM patients diagnosed during the study period, 80 (13.9%) that were associated with PE were identified and analyzed...
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28796988/microvessel-density-as-a-surrogate-prognostic-marker-in-patients-with-multiple-myeloma-a-meta-analysis
#20
Panagiotis Ntellas, Konstantinos Perivoliotis, Katerina Dadouli, Georgios K Koukoulis, Maria Ioannou
BACKGROUND/AIMS: Bone marrow (BM) angiogenesis is considered a hallmark of multiple myeloma (MM) development and progression, and can be quantified with the use of microvessel density (MVD). The purpose of this study is to provide a review and a meta-analysis of the current literature regarding the prognostic value of MVD in the overall survival (OS) of MM patients. METHODS: MEDLINE was screened for studies evaluating the OS of MM patients with regard to their MVD count in BM trephine...
2017: Acta Haematologica
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