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Acta Haematologica

Tsuyoshi Takahashi
No abstract text is available yet for this article.
July 13, 2018: Acta Haematologica
Toyomi Kamesaki, Eiji Kajii
BACKGROUND: Direct antiglobulin test (DAT)-negative warm autoimmune hemolytic anemia (AIHA) is mainly caused by three mechanisms: red blood cell (RBC)-bound immunoglobulin (Ig)G below the detection limit of routine DAT; RBC-bound IgA or IgM; or low-affinity autoantibodies. Although most cases of DAT-negative AIHA are thought to be caused by RBC-bound IgG, and combinatory serological analyses are recommended, the relative ratios of each mechanism have not been clarified. METHODS: Two groups of patients with undiagnosed hemolytic anemia and negative conventional tube method-DAT (TM-DAT) were investigated using anti-IgA and anti-IgM sera, or column agglutination method-DAT (CM-DAT), respectively, in addition to radioimmunological quantitation of RBC-bound IgG...
July 13, 2018: Acta Haematologica
Bruno Neuner, Henning Krampe, William J McCarthy, Sarah Reinke, Dorothee Kowalski, Hartmut Clausnizer, Maria Shneyder, Angela Rocke, Ulrike Nowak-Göttl
BACKGROUND/AIMS: The generic quality of life KINDL-R -questionnaire is validated for use in children/adolescents ≤16 years. The aim of this cross-sectional investigation was to modify the KINDL-R questionnaire for use in adults and to validate its psychometric properties. METHODS: Five items of the KINDL-R questionnaire were adapted and the newly developed KINDL-A(dult) questionnaire administered to 255 patients with hereditary and acquired bleeding disorders (mean age 53 years)...
July 13, 2018: Acta Haematologica
Tarek E Selim, Hanan A Azzam, Hayam R Ghoneim, Ahmed A Mohamed, Hossam El Wakeel, Helmy M Abu Bakr
BACKGROUND/AIMS: Data from previous reports, addressing the significance of genotype-guided dosing of warfarin in Egyptian patients, are infrequent and controversial. This study is aimed at demonstrating the validity of genetic dosing algorithms in Egyptian patients on warfarin therapy. METHODS: A total of 100 Egyptian patients on a stable maintenance daily dose of warfarin were enrolled. The predicted warfarin dose for each patient was calculated using the warfarin dosing table, the Gage and the International Warfarin Pharmacogenetics Consortium (IWPC) clinical algorithms and the Gage and the IWPC genetic algorithms and compared to the actual dose...
July 11, 2018: Acta Haematologica
Martin Bommer, Miriam Kull, Veronica Teleanu, Phyllis Schwarzwälder, Manuela Feuring-Buske, Jan Kroenke, Donald Bunjes, Christian Langer
INTRODUCTION: Involvement of the central nervous system in patients with multiple myeloma is a rare event. We evaluated the diagnostic workup and prognosis of patients with leptomeningeal myelomatosis (LMM). METHODS: Between April 2005 and April 2016, we identified 16 cases with LMM. The involvement was diagnosed by magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) cytology as well as flow cytometry. Fluorescence in situ hybridization (FISH) was used in 8/16 cases...
July 11, 2018: Acta Haematologica
Maya Koren-Michowitz
No abstract text is available yet for this article.
June 26, 2018: Acta Haematologica
Sabrina Mariani, Giovanna Palumbo, Luisa Cardarelli, Michelina Santopietro, Robin Foà, Fiorina Giona
BACKGROUND: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis. CASE REPORT: We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia. Based on bone marrow (BM) findings and on liver biopsy showing extramedullary hematopoiesis, an initial diagnosis of PMF was formulated. The patient refused stem cell transplantation from an HLA-identical sibling...
June 26, 2018: Acta Haematologica
Frances Buckley, Alan Norris, Ron Kerr
No abstract text is available yet for this article.
June 26, 2018: Acta Haematologica
Carla Minoia, Sabino Ciavarella, Giovanna Lerario, Antonella Daniele, Simona De Summa, Mariarosaria Napolitano, Attilio Guarini
No abstract text is available yet for this article.
June 21, 2018: Acta Haematologica
Matevz Skerget, Barbara Skopec, Vesna Zadnik, Darja Zontar, Helena Podgornik, Katarina Rebersek, Tadej Furlan, Peter Cernelc
OBJECTIVES: In this retrospective study, we evaluated the impact of CD56, CD117, and CD28 expression on clinical characteristics and survival in newly diagnosed myeloma patients treated with bortezomib-based induction therapy. METHODS: We analyzed 110 myeloma patients. Immunophenotype was determined using panels consisting of CD19/CD38/CD45/CD56/CD138 and CD20, CD28, and CD117 were used additionally. All samples were tested for recurrent chromosomal aberrations...
June 19, 2018: Acta Haematologica
Han-Seung Park, Dae-Young Kim, Eun-Ji Choi, Jung-Hee Lee, Je-Hwan Lee, Mijin Jeon, Young-Ah Kang, Young-Shin Lee, Miee Seol, Young-Uk Cho, Seongsoo Jang, Hyun-Sook Chi, Kyoo-Hyung Lee, Chan-Jeoung Park
The prognosis of adult acute lymphoblastic leukemia is much worse than that of pediatric acute lymphoblastic leukemia, even when patients achieve complete remission. Early response to treatment can be an important alternative indicator of treatment outcomes. The purpose of our current study was to identify the prognostic value of the blast percentage of the induction interim bone marrow, which might predict relapse-free survival and overall survival in patients with adult acute lymphoblastic leukemia. A retrospective analysis was performed on 80 adult patients diagnosed with Philadelphia chromosome-negative acute lymphoblastic leukemia from 1994 to 2011...
June 1, 2018: Acta Haematologica
Mark A Catherwood, Amy Graham, Robert J G Cuthbert, Celine Garrec, Betty Gardie, François Girodon, Sophie Laird, Nicholas C P Cross, Mary Frances McMullin
No abstract text is available yet for this article.
May 30, 2018: Acta Haematologica
Zhiguang Lin, Bobin Chen, Ting Wu, Xiaoping Xu
BACKGROUND/AIMS: Diffuse large B cell lymphoma (DLBCL) is heterogeneous. We aimed to explore how tumor microenvironment promotes lymphoma cell aggressiveness and heterogeneity. METHODS: We created a coculture system using human DLBCL cells and mouse bone marrow stromal cells. Proliferative capacity, drug resistance, clonogenicity, and tumorigenicity were compared in lymphoma cells from the coculture system and lymphoma cells cultured alone. Expression of Notch signaling associated genes was evaluated using real-time reverse transcriptase PCR and Western blot...
May 23, 2018: Acta Haematologica
Firas El Chaer, Noa G Holtzman, Maria R Baer, Ann B Zimrin, Jennie Y Law
No abstract text is available yet for this article.
2018: Acta Haematologica
Michael Asger Andersen, Ole Weis Bjerrum, Ajenthen Ranjan, Vibe Skov, Torben A Kruse, Mads Thomassen, Axel Skytthe, Hans Carl Hasselbalch, Kaare Christensen
OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown. METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry...
2018: Acta Haematologica
Robert Peter Gale
No abstract text is available yet for this article.
2018: Acta Haematologica
Jihoon Kang, Jung Yong Hong, Dok Hyun Yoon, Shin Kim, Kyoung Min Lee, Jung Sun Park, Chan-Jeoung Park, Won-Ki Min, Eul-Ju Seo, Seongsoo Jang, Cheolwon Suh
BACKGROUND: Immunoglobulin D multiple myeloma (IgD MM) is characterized by a poor prognosis. Data are lacking on the survival benefits associated with the use of novel agents followed by autologous stem cell transplantation (ASCT) in IgD MM patients. We evaluated the clinical outcomes of induction treatment with novel agents followed by ASCT. METHODS: This was a single-center, retrospective study of 22 IgD MM patients who underwent ASCT between 1995 and 2016. Of these, 10 (45...
2018: Acta Haematologica
Richard J Burden, Charles R Pedlar
No abstract text is available yet for this article.
2018: Acta Haematologica
Hui Lv, Shaoyan Hu, Jun Lu, Qin Zhai, Zong Zhai, Zhizhuo Du, Yina Sun, Jie Li, Hailong He, Yi Wang
The 8p11 myeloproliferative syndrome (EMS) is an aggressive neoplasm associated with chromosomal translocations involving the fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase gene on chromosome 8p11-12. A new case of a 9-year-old boy with leukocytosis, eosinophilia, and general lymphadenopathy is reported in this study. Bone marrow examination showed eosinophilic hyperplasia, with blast cells amounting to 6-7%. Karyotyping revealed cytogenetic abnormalities, including t(8;9)(p11.2;q3?3). Fluorescence in situ hybridization for the FGFR1 gene rearrangement yielded positive results...
2018: Acta Haematologica
Yidan Gao, Binbin Zhang, Yiran Song, Ge Li, Yanting Bao, Yanming Jiang, Ling Gao, Gongying Chen, Jie Wang
No abstract text is available yet for this article.
2018: Acta Haematologica
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