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Acta Haematologica

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https://www.readbyqxmd.com/read/28797003/pleural-effusion-in-multiple-myeloma-characteristics-and-practice-patterns
#1
Ja Min Byun, Ki Hwan Kim, In Sil Choi, Jin Hyun Park, Jin-Soo Kim, Dong-Yeop Shin, Youngil Koh, Inho Kim, Sung-Soo Yoon, Hyo Jeong Lim
In many Asian countries battling with the double burden of increasing noninfectious diseases on top of infectious diseases, multiple myeloma (MM) patients presenting with pleural effusion (PE) pose a great diagnostic challenge. Thus, we aimed to analyze the clinical features and practice patterns of such patients. This is a multicenter retrospective study of newly diagnosed MM patients between January 2011 and December 2015. Among 575 MM patients diagnosed during the study period, 80 (13.9%) that were associated with PE were identified and analyzed...
August 11, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28796988/microvessel-density-as-a-surrogate-prognostic-marker-in-patients-with-multiple-myeloma-a-meta-analysis
#2
Panagiotis Ntellas, Konstantinos Perivoliotis, Katerina Dadouli, Georgios K Koukoulis, Maria Ioannou
BACKGROUND/AIMS: Bone marrow (BM) angiogenesis is considered a hallmark of multiple myeloma (MM) development and progression, and can be quantified with the use of microvessel density (MVD). The purpose of this study is to provide a review and a meta-analysis of the current literature regarding the prognostic value of MVD in the overall survival (OS) of MM patients. METHODS: MEDLINE was screened for studies evaluating the OS of MM patients with regard to their MVD count in BM trephine...
August 11, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28793303/pleural-effusion-in-multiple-myeloma-a-liquid-state
#3
Hila Magen
No abstract text is available yet for this article.
August 10, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28793294/an-editor-in-chief-s-farewell
#4
Isaac Ben-Bassat
No abstract text is available yet for this article.
August 10, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28793290/publisher-s-note
#5
Gabriella Karger
No abstract text is available yet for this article.
August 10, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28793289/passing-on-the-baton
#6
Pia Raanani
No abstract text is available yet for this article.
August 10, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28743121/a-severe-case-of-hemoglobin-h-disease-due-to-compound-heterozygosity-for-deletion-of-the-major-%C3%AE-globin-regulatory-element-mcs-r2-and-%C3%AE-0-thalassemia
#7
Lv-Yin Huang, Jin-Mei Yan, Jian-Ying Zhou, Jian Li, Xing-Mei Xie, Dong-Zhi Li
No abstract text is available yet for this article.
July 26, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28743106/the-complexities-of-defining-a-complex-karyotype-in-hematological-malignancies-a-need-for-standardization
#8
Jess F Peterson
No abstract text is available yet for this article.
July 26, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28728162/realistic-lenalidomide-dose-adjustment-strategy-for-transplant-ineligible-elderly-patients-with-relapsed-refractory-multiple-myeloma-japanese-real-world-experience
#9
Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura
Lenalidomide is an immunomodulatory drug administered orally in the treatment of multiple myeloma. Some elderly patients require a reduced lenalidomide dose because of comorbidities and/or adverse events. This study investigated the actual dose of lenalidomide in elderly patients, finding that most received reduced (5-10 mg) doses. The most common reasons for dose reduction were renal dysfunction (54% of patients), fatigue (grade ≥3; 20%), hematologic disorder (grade ≥3; 14%), and rash (grade ≥3; 9%)...
July 21, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28723683/very-low-dose-lenalidomide-for-elderly-and-or-frail-multiple-myeloma-patients-lower-might-be-better
#10
Kentaro Minagawa, Corey P Falcon, Toshimitsu Matsui
No abstract text is available yet for this article.
July 20, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28723682/release-of-danger-associated-molecular-patterns-following-chemotherapy-does-not-induce-immunoparalysis-in-leukemia-patients
#11
Kim Timmermans, Guus P Leijte, Matthijs Kox, Gert Jan Scheffer, Nicole M A Blijlevens, Peter P Pickkers
Chemotherapy may result in the release of danger-associated molecular patterns (DAMPs), which can cause immunoparalysis (deactivation of the immune system). We investigated DAMPs following chemotherapy and their relationship with markers of immunoparalysis in leukemia patients. In 6 patients with acute myeloid leukemia or myelodysplastic syndrome and 12 healthy subjects, DAMPs, cytokines, and markers of immunoparalysis were determined before and during the first week after chemotherapy initiation. In the patients, plasma levels of nuclear DNA (a marker of general DAMP release) were profoundly increased before chemotherapy and further increased 4-6 h afterwards, while the specific DAMP mitochondrial DNA showed only a trend towards increase...
July 20, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28719902/serum-hyaluronic-acid-levels-are-altered-in-acute-leukemia-patients-potential-prognostic-implications
#12
Eleni Anagnostopoulou, Chrysanthi Papanastasopoulou, Maria Papastamataki, Antonia Kotsiou, Zoi Topouzoglou, Nikolaos Anagnostopoulos, Nikolaos Sitaras
BACKGROUND: Studies on the serum concentration of hyaluronic acid (HA) in newly diagnosed patients with acute myeloid leukemia (AML), B-acute lymphoblastic leukemia (B-ALL), and mantle-cell lymphoma (MCL) are scarce. In this study, we focused on investigating whether HA could serve as a possible prognostic marker in patients with AML, B-ALL, and MCL. METHODS: The serum concentration of HA was measured in a total of 51 patients with newly diagnosed AML, B-ALL, and MCL...
July 19, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28668960/genetic-heterogeneity-in-chronic-lymphocytic-leukemia-what-can-conventional-cytogenetics-add
#13
José-Ángel Hernández-Rivas, Isabel González-Gascón Y Marín
No abstract text is available yet for this article.
July 1, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28668948/limited-role-of-random-skin-biopsy-in-the-diagnosis-of-intravascular-lymphoma-in-adult-patients-with-hemophagocytic-lymphohistiocytosis
#14
Hyunje G Cho, Sarah L Sheu, Karen Y Kuo, Mina S Ally, Elizabeth E Bailey, Jinah Kim, Bernice Y Kwong
BACKGROUND/AIMS: This study examined the role of random normal skin biopsy in the diagnosis of intravascular lymphoma (IVL) in adult Western patients with clinically diagnosed hemophagocytic lymphohistiocytosis (HLH). METHODS: In a retrospective chart review study, we analyzed a total of 59 skin biopsies that were performed to diagnose IVL in 21 adult patients with HLH seen at Stanford Hospital between 2004 and 2016. RESULTS: Out of the 59 skin biopsies, 42 were taken from clinically normal-appearing skin and 17 from clinically abnormal-appearing skin...
July 1, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28614815/a-case-of-pulmonary-langerhans-cell-sarcoma-simultaneously-diagnosed-with-cutaneous-langerhans-cell-histiocytosis-studied-by-whole-exome-sequencing
#15
Si-Wook Kim, Moon Ki Choi, Hye Sook Han, Hyojin Song, Youngil Koh, Seung-Myoung Son, Ok-Jun Lee, Ji Yeoun Lee, Ki Man Lee, Ki Hyeong Lee, Jihyun Kwon
Langerhans cell histiocytosis (LCH) and Langerhans cell sarcoma (LCS) are clonal proliferations of Langerhans-type cells. Unlike in LCH, the pathophysiology and clinical course of LCS are unclear due to its rarity. Here, we report the case of a 73-year-old male patient who was diagnosed with cutaneous LCH and pulmonary LCS at the same time. Pathological review of these 2 tumors revealed similar immunohistochemical findings. However, the tumor cells in LCS had more aggressive cytological features than those in LCH...
June 15, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28614806/review-of-rosai-dorfman-disease-new-insights-into-the-pathogenesis-of-this-rare-disorder
#16
Yanan Cai, Zhangzhen Shi, Yuansong Bai
Rosai-Dorfman disease (RDD) is a rare histiocytosis typically with bilateral painless cervical lymphadenopathy. Laboratory data are nonspecific, and the presence of emperipolesis in large foamy S-100+ CD1a- histiocytes is the prominent histologic feature. The pathogenesis of RDD still remains elusive. According to published studies, we propose that RDD cells might represent intermediate recruiting monocytes with differentiation blockade. Both disturbance of homoeostasis and inherent genomic alterations could contribute to initiation of the disorder through signal transduction...
June 15, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28595168/reactivation-of-multiple-infectious-pathogens-after-hematopoietic-stem-cell-transplantation
#17
Chen Sabrina Tan
No abstract text is available yet for this article.
June 9, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28591758/are-the-polyomaviruses-bk-and-jc-associated-with-opportunistic-infections-graft-versus-host-disease-or-worse-outcomes-in-adult-patients-receiving-their-first-allogeneic-stem-cell-transplantation-with-low-dose-alemtuzumab
#18
Laila Schneidewind, Thomas Neumann, Florian Knoll, Kathrin Zimmermann, Sigrun Smola, Christian Andreas Schmidt, William Krüger
BACKGROUND: The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed. METHODS: We conducted a retrospective study of 64 adult patients who received their first allogeneic stem cell transplantation between March 2010 and December 2014; the follow-up time was 2 years. RESULTS: Acute leukemia was the most frequent underlying disease (45...
June 8, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28586772/clinical-features-and-recurrence-pattern-of-perianal-abscess-in-patients-with-acute-myeloid-leukemia
#19
Hung Chang, Ming-Chung Kuo, Tzung-Chih Tang, Tung-Liang Lin, Jin-Hou Wu, Yu-Shin Hung, Po-Nan Wang
INTRODUCTION: Perianal abscess may develop during neutropenia periods in patients with acute myeloid leukemia (AML). The standard of care for perianal abscess in AML is unclear. METHODS: We retrospectively collected patient data in our institute from 2009 to 2012. RESULTS: Two hundred ninety-two patients with AML were analyzed. In total, 1,051 chemotherapy sessions were administered. Twenty-three patients experienced perianal abscess. Patients with perianal abscess were younger than those without (44 vs...
June 7, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28586777/patients-with-fever-of-unknown-origin-and-splenomegaly-diagnostic-value-of-splenectomy-and-preoperative-risk-factors-suggestive-of-underlying-lymphomas
#20
Lu Zhang, Wei Zhang, Huacong Cai, Xinxin Cao, Miao Chen, Jian Li, Tienan Zhu, Minghui Duan, Shujie Wang, Bing Han, Daobin Zhou
BACKGROUND: We reviewed patients with fever of unknown origin (FUO) and splenomegaly and assessed the diagnostic value of splenectomy and measured risk factors suggestive of an underlying lymphoma. METHODS: FUO patients (n = 83) who had splenomegaly and underwent splenectomy were enrolled into this retrospective single-center study. Clinical presentations were documented and risk factors suggestive of an underlying lymphoma were tested. RESULTS: Seventy-four patients (89...
2017: Acta Haematologica
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