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Acta Haematologica

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https://www.readbyqxmd.com/read/29791894/highly-tumorigenic-diffuse-large-b-cell-lymphoma-cells-are-produced-by-coculture-with-stromal-cells
#1
Zhiguang Lin, Bobin Chen, Ting Wu, Xiaoping Xu
BACKGROUND/AIMS: Diffuse large B cell lymphoma (DLBCL) is heterogeneous. We aimed to explore how tumor microenvironment promotes lymphoma cell aggressiveness and heterogeneity. METHODS: We created a coculture system using human DLBCL cells and mouse bone marrow stromal cells. Proliferative capacity, drug resistance, clonogenicity, and tumorigenicity were compared in lymphoma cells from the coculture system and lymphoma cells cultured alone. Expression of Notch signaling associated genes was evaluated using real-time reverse transcriptase PCR and Western blot...
May 23, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29734168/sickle-cell-disease-complicated-by-iron-overload-an-under-recognized-risk-factor-for-vibrio-vulnificus-infection
#2
Firas El Chaer, Noa G Holtzman, Maria R Baer, Ann B Zimrin, Jennie Y Law
No abstract text is available yet for this article.
May 7, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29719285/myeloproliferative-neoplasms-in-danish-twins
#3
Michael Asger Andersen, Ole Weis Bjerrum, Ajenthen Ranjan, Vibe Skov, Torben A Kruse, Mads Thomassen, Axel Skytthe, Hans Carl Hasselbalch, Kaare Christensen
OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown. METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry...
May 2, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29642063/therapy-for-immunoglobulin-d-plasma-cell-myeloma
#4
Robert Peter Gale
No abstract text is available yet for this article.
April 11, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29635247/efficacy-and-survival-outcome-associated-with-the-use-of-novel-agents-and-autologous-stem-cell-transplantation-in-cases-of-immunoglobulin-d-multiple-myeloma-in-korea
#5
Jihoon Kang, Jung Yong Hong, Dok Hyun Yoon, Shin Kim, Kyoung Min Lee, Jung Sun Park, Chan-Jeoung Park, Won-Ki Min, Eul-Ju Seo, Seongsoo Jang, Cheolwon Suh
BACKGROUND: Immunoglobulin D multiple myeloma (IgD MM) is characterized by a poor prognosis. Data are lacking on the survival benefits associated with the use of novel agents followed by autologous stem cell transplantation (ASCT) in IgD MM patients. We evaluated the clinical outcomes of induction treatment with novel agents followed by ASCT. METHODS: This was a single-center, retrospective study of 22 IgD MM patients who underwent ASCT between 1995 and 2016. Of these, 10 (45...
April 10, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29621767/understanding-iron-deficiency-and-exercise-looking-beyond-ferritin
#6
Richard J Burden, Charles R Pedlar
No abstract text is available yet for this article.
April 5, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29614500/precursor-t-lymphoblastic-lymphoma-associated-with-t-8-9-p11-2-q33-a-case-report-and-review-of-the-literature
#7
Hui Lv, Shaoyan Hu, Jun Lu, Qin Zhai, Zong Zhai, Zhizhuo Du, Yina Sun, Jie Li, Hailong He, Yi Wang
The 8p11 myeloproliferative syndrome (EMS) is an aggressive neoplasm associated with chromosomal translocations involving the fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase gene on chromosome 8p11-12. A new case of a 9-year-old boy with leukocytosis, eosinophilia, and general lymphadenopathy is reported in this study. Bone marrow examination showed eosinophilic hyperplasia, with blast cells amounting to 6-7%. Karyotyping revealed cytogenetic abnormalities, including t(8;9)(p11.2;q3?3). Fluorescence in situ hybridization for the FGFR1 gene rearrangement yielded positive results...
April 4, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29597199/diagnosis-of-hereditary-spherocytosis-and-secondary-hemochromatosis-in-a-patient-with-jaundice
#8
Yidan Gao, Binbin Zhang, Yiran Song, Ge Li, Yanting Bao, Yanming Jiang, Ling Gao, Gongying Chen, Jie Wang
No abstract text is available yet for this article.
March 29, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29597195/coping-with-iron-deficiency-and-iron-deficiency-anemia-in-combat-recruits
#9
Drorit Merkel, Daniel S Moran
No abstract text is available yet for this article.
March 29, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29597188/early-fluorescence-in-situ-hybridization-assessment-during-acute-myeloid-leukemia-induction-chemotherapy
#10
Robert Schneidewend, Paul Hosking, Ruta Brazauskas, Jess Peterson, Carlie Beaudin, Laura Michaelis, Ehab Atallah, Parameswaran Hari, Karen Carlson
No abstract text is available yet for this article.
March 29, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29597187/combination-therapy-with-ruxolitinib-and-hydroxyurea-for-the-treatment-of-myeloid-predominant-leukocytosis-in-a-patient-with-myelofibrosis
#11
Giovanni Caocci, Silvia Ghiani, Cristina Mocci, Giorgio La Nasa
No abstract text is available yet for this article.
March 29, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29550825/effect-of-centrifuge-temperature-on-routine-coagulation-tests
#12
Hayrullah Yazar, Fatma Özdemir, Elif Köse
BACKGROUND: This study investigated the effects of cooled and standard centrifuges on the results of coagulation tests to examine the effects of centrifugation temperature. METHODS: Equal-volume blood samples from each patient were collected at the same time intervals and subjected to standard (25°C) and cooled centrifugation (2-4°C). Subsequently, the prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer values were determined in runs with the same lot numbers in the same coagulation device using the Dia-PT R (PT and INR), Dia-PTT-liquid (aPTT), Dia-FIB (fibrinogen), and Dia-D-dimer kits, respectively...
March 16, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29550822/retrospective-analysis-of-a-new-prognostic-score-for-diffuse-large-b-cell-lymphoma-based-on-interim-positron-emission-tomography-computed-tomography
#13
TingBo Liu, LiHong Chen, Jie Pan, LiLi Pan, JianDa Hu, ZhongYou Ji
BACKGROUND: The International Prognostic Index (IPI) scoring system is the most widely used prognostic tool for diffuse large B-cell lymphoma (DLBCL); however, it fails to consistently identify patients with poor outcomes. This retrospective study was undertaken to confirm the clinical value of a new prognostic score and compare it with the IPI. METHODS: The aim of this single-center study was to confirm the clinical value of a new prognostic score and its association with various clinical features, disease progression, and death in 70 patients with DLBCL who had undergone at least 6 cycles of chemotherapy...
March 16, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29478071/prevalence-of-iron-deficiency-and-iron-deficiency-anemia-in-strenuously-training-male-army-recruits
#14
Danny Epstein, Ariel Borohovitz, Ilan Merdler, Moran Furman, Emmanuel Atalli, Alex Sorkin, Yaniv Stainfeld, Yoni Isenberg, Tanya Mashiach, Shachar Shapira, Roni Weisshof, Eldad J Dann
OBJECTIVES: The objectives of our study were to determine the effect of strenuous physical training on the prevalence of iron deficiency anemia (IDA), iron deficiency (ID) with normal hemoglobin (Hb), and anemia without ID. METHODS: Our study was a prospective observational study. We followed 115 healthy male recruits in the Israel Defense Forces elite units during 15 months of training. Blood samples were collected at recruitment and at 6-, 9- and 15-month follow-ups...
February 23, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29455198/incidence-survival-and-risk-factors-for-adults-with-acute-myeloid-leukemia-not-otherwise-specified-and-acute-myeloid-leukemia-with-recurrent-genetic-abnormalities-analysis-of-the-surveillance-epidemiology-and-end-results-seer-database-2001-2013
#15
Xiaolu Song, Ye Peng, Xiaogang Wang, Yirui Chen, Lai Jin, Tianxin Yang, Meihua Qian, Wanmao Ni, Xiangmin Tong, Jianping Lan
BACKGROUND/AIM: As the knowledgebase of acute myeloid leukemia (AML) has grown, classification systems have moved to incorporate these new findings. METHODS: We assessed 32,941 patients with AML whose records are contained in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Half of all patients diagnosed between 2001 and 2013 did not have a World Health Organization (WHO) classification. Acute promyelocytic leukemia and acute panmyelosis with myelofibrosis were associated with the longest leukemia-specific survival (110 and 115 months, respectively), and AML with minimal differentiation and acute megakaryoblastic leukemia with the shortest (30 and 28 months, respectively)...
2018: Acta Haematologica
https://www.readbyqxmd.com/read/29444505/no-mutation-left-behind-the-impact-of-reporting-recurrent-genetic-abnormalities-on-outcomes-of-patients-with-acute-myeloid-leukemia
#16
Andrew M Brunner
No abstract text is available yet for this article.
2018: Acta Haematologica
https://www.readbyqxmd.com/read/29444503/whither-the-bone-marrow-transplantation-in-multiple-myeloma
#17
Guillermo J Ruiz-Argüelles
No abstract text is available yet for this article.
2018: Acta Haematologica
https://www.readbyqxmd.com/read/29444501/quercetin-therapy-for-selected-patients-with-pim1-kinase-positive-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-a-pilot-study
#18
Beverly W Baron, Michael J Thirman, Mihai C Giurcanu, Joseph M Baron
We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro. Under an Institutional Review Board-approved protocol, we performed an open-label, single-arm pilot study to evaluate the antitumor activity of quercetin in patients with CLL/SLL. Q-ForceTM chews were administered orally, 500 mg twice daily, for 3 months...
2018: Acta Haematologica
https://www.readbyqxmd.com/read/29414800/autologous-hematopoietic-cell-transplantation-for-dialysis-dependent-myeloma-more-efficient-less-toxic
#19
Odelia Amit, Ron Ram
No abstract text is available yet for this article.
2018: Acta Haematologica
https://www.readbyqxmd.com/read/29414797/plasma-cell-disorders-and-dialysis-dependent-renal-failure-safety-and-efficacy-of-autologous-stem-cell-transplantation
#20
Francesca Martini, Gabriele Buda, Enrico Orciuolo, Sara Galimberti, Francesco Mazziotta, Mario Petrini
No abstract text is available yet for this article.
2018: Acta Haematologica
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