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Acta Haematologica

Hayrullah Yazar, Fatma Özdemir, Elif Köse
BACKGROUND: This study investigated the effects of cooled and standard centrifuges on the results of coagulation tests to examine the effects of centrifugation temperature. METHODS: Equal-volume blood samples from each patient were collected at the same time intervals and subjected to standard (25°C) and cooled centrifugation (2-4°C). Subsequently, the prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer values were determined in runs with the same lot numbers in the same coagulation device using the Dia-PT R (PT and INR), Dia-PTT-liquid (aPTT), Dia-FIB (fibrinogen), and Dia-D-dimer kits, respectively...
March 16, 2018: Acta Haematologica
TingBo Liu, LiHong Chen, Jie Pan, LiLi Pan, JianDa Hu, ZhongYou Ji
BACKGROUND: The International Prognostic Index (IPI) scoring system is the most widely used prognostic tool for diffuse large B-cell lymphoma (DLBCL); however, it fails to consistently identify patients with poor outcomes. This retrospective study was undertaken to confirm the clinical value of a new prognostic score and compare it with the IPI. METHODS: The aim of this single-center study was to confirm the clinical value of a new prognostic score and its association with various clinical features, disease progression, and death in 70 patients with DLBCL who had undergone at least 6 cycles of chemotherapy...
March 16, 2018: Acta Haematologica
Danny Epstein, Ariel Borohovitz, Ilan Merdler, Moran Furman, Emmanuel Atalli, Alex Sorkin, Yaniv Stainfeld, Yoni Isenberg, Tanya Mashiach, Shachar Shapira, Roni Weisshof, Eldad J Dann
OBJECTIVES: The objectives of our study were to determine the effect of strenuous physical training on the prevalence of iron deficiency anemia (IDA), iron deficiency (ID) with normal hemoglobin (Hb), and anemia without ID. METHODS: Our study was a prospective observational study. We followed 115 healthy male recruits in the Israel Defense Forces elite units during 15 months of training. Blood samples were collected at recruitment and at 6-, 9- and 15-month follow-ups...
February 23, 2018: Acta Haematologica
Xiaolu Song, Ye Peng, Xiaogang Wang, Yirui Chen, Lai Jin, Tianxin Yang, Meihua Qian, Wanmao Ni, Xiangmin Tong, Jianping Lan
BACKGROUND/AIM: As the knowledgebase of acute myeloid leukemia (AML) has grown, classification systems have moved to incorporate these new findings. METHODS: We assessed 32,941 patients with AML whose records are contained in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Half of all patients diagnosed between 2001 and 2013 did not have a World Health Organization (WHO) classification. Acute promyelocytic leukemia and acute panmyelosis with myelofibrosis were associated with the longest leukemia-specific survival (110 and 115 months, respectively), and AML with minimal differentiation and acute megakaryoblastic leukemia with the shortest (30 and 28 months, respectively)...
February 16, 2018: Acta Haematologica
Andrew M Brunner
No abstract text is available yet for this article.
February 14, 2018: Acta Haematologica
Guillermo J Ruiz-Argüelles
No abstract text is available yet for this article.
February 14, 2018: Acta Haematologica
Beverly W Baron, Michael J Thirman, Mihai C Giurcanu, Joseph M Baron
We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro. Under an Institutional Review Board-approved protocol, we performed an open-label, single-arm pilot study to evaluate the antitumor activity of quercetin in patients with CLL/SLL. Q-ForceTM chews were administered orally, 500 mg twice daily, for 3 months...
February 14, 2018: Acta Haematologica
Odelia Amit, Ron Ram
No abstract text is available yet for this article.
February 7, 2018: Acta Haematologica
Francesca Martini, Gabriele Buda, Enrico Orciuolo, Sara Galimberti, Francesco Mazziotta, Mario Petrini
No abstract text is available yet for this article.
February 7, 2018: Acta Haematologica
Wictor Aronsson-Kurttila, Arjang Baygan, Gianluca Moretti, Mats Remberger, Bita Khoein, Guido Moll, Behnam Sadeghi, Olle Ringdén
BACKGROUND/AIMS: Hemorrhagic cystitis (HC) is a serious complication after hematopoietic stem cell transplantation (HSCT). Stromal cells have been tested as therapy for HC. Decidua stromal cells (DSCs) protect the fetus from the mother's immune system. METHODS: Eleven patients with HC of grades 3-4 were treated with DSCs after HSCT. The median age was 33 years (range 8-50), and the median dose of DSCs was 1.5 × 106/kg (range 0.7-2.5). The patients were given 1 dose (1-4)...
February 7, 2018: Acta Haematologica
Alexey Glazyrin, Chirag Patel, Lara Kujtan, Sheshadri Madhusudhana
Low-grade follicular lymphomas are genetically characterized by the translocation t(14; 18)(q32;q21) with BCL2 gene rearrangements. Marginal zone lymphomas are often associated with translocations or transcriptional deregulations of the MALT gene. We report 2 cases of lymphomas which harbor both the t(14;18)(q32;q21) translocation and MALT gene upregulation. Patients presented with numerous circulating atypical lymphocytes. Lymph node biopsy in both cases on HE staining demonstrated vague nodularity readily highlighted by CD10, CD23, or BCL6...
February 6, 2018: Acta Haematologica
Raphael E Steiner, Robert Z Orlowski, Hans C Lee
BACKGROUND: Acute pancreatitis is an uncommon complication of anti-myeloma agents. Ixazomib is a first-in-class oral proteasome inhibitor to receive regulatory approval for the treatment of multiple myeloma. This case report describes the first case of ixazomib-associated pancreatitis. CASE PRESENTATION: An 80-year-old female with relapsed multiple myeloma presented with severe diarrhea, nausea, vomiting, abdominal pain, and acute renal failure 3 weeks after starting ixazomib and dexamethasone for disease progression...
February 2, 2018: Acta Haematologica
Yushan Cui, Yang Liu, Danyang Wang, Yuzhang Liu, Lina Liu, Baijun Fang
BACKGROUND: Multiple myeloma (MM) with 1q21 gains invariably has a poor prognosis. Many recent studies have reported the relationship between micro (mi)RNA expression and MM prognosis. However, there is little information on the association between miRNA alterations and 1q21 gains. METHODS: We compared the miRNA expression profiles of MM with 1q21 gains and MM with normal fluorescence in situ hybridisation (FISH) by gene expression array. Differentially expressed miRNAs were identified using Affymetrix TAC software...
February 2, 2018: Acta Haematologica
Hiroki Hosoi, Toshiki Mushino, Akinori Nishikawa, Shogo Murata, Kodai Kuriyama, Yusuke Yamashita, Hiroshi Kobata, Takehiro Ooiwa, Nobuyoshi Hanaoka, Shinobu Tamura, Takashi Sonoki
No abstract text is available yet for this article.
February 1, 2018: Acta Haematologica
Xi Tang, Jiao Zhou, Jing Zhang, Ling-Yu Zhou, Ling-Ling Zhai, Minse Evola-Deniz Vanessa, Jing Yi, Yun-Yun Yi, Jiang Lin, Zhao-Qun Deng
FUS1 is a tumor suppressor gene that has been found to be frequently lost in a variety of solid tumors. In this study, we aimed to investigate the expression status of the FUS1 gene in acute myeloid leukemia (AML), as well as its clinical significance. We further explored the correlation between the expression of FUS1 and miR-378 in AML. We detected expression of the FUS1 transcript in bone marrow mononuclear cells from 23 controls and 158 newly diagnosed AML patients by real-time quantitative polymerase chain reaction...
February 1, 2018: Acta Haematologica
Yvette Hoade, Georgia Metzgeroth, Juliana Schwaab, Andreas Reiter, Nicholas C P Cross
No abstract text is available yet for this article.
January 26, 2018: Acta Haematologica
Xavier A Andrade, Luis H Paz, Mo''ath Nassar, Diana M Oramas, Harry E Fuentes, Paula Kovarik, Satya Mishra, Anshu Singh
INTRODUCTION: Hepatitis C infection is highly prevalent worldwide and has a well-known association with B-cell lymphoid malignancies. Antiviral therapy has successfully decreased the rate of liver cirrhosis and improved the outcome in patients with hepatitis C-associated lymphomas. However, although there are a few case reports of aggressive lymphomas after successful hepatitis C therapy, the mechanism behind this association remains unclear. CASE PRESENTATION: We present the case of a 55-year-old man with chronic hepatitis C infection and liver cirrhosis who received antiviral therapy with sofosbuvir and ribavirin and achieved a sustained complete virological response...
January 26, 2018: Acta Haematologica
Linda Calistri, Benedetta Puccini, Valentina Berti, Giulia Grazzini, Cosimo Nardi, Luigi Rigacci, Stefano Colagrande
No abstract text is available yet for this article.
January 26, 2018: Acta Haematologica
Ben-Jin He, Lin Liao, Zeng-Fu Deng, Yi-Feng Tao, Yu-Chan Xu, Fa-Quan Lin
With the widespread use of genetic diagnostic technologies, many novel mutations have been identified in hereditary spherocytosis (HS)-related genes, including SPTA1, SPTB, ANK1, SLC4A1, and EPB42. However, mutations in HS-related genes are dispersed and nonspecific in the diagnosis of some HS patients, indicating significant heterogeneity in the molecular deficiency of HS. It is necessary to provide the molecular and genetic characteristics of these 5 genes for clinicians to examine HS. Here, we reviewed the recent proposed molecular genetic mechanisms of HS...
January 22, 2018: Acta Haematologica
Siriyakorn Chansai, Supan Fucharoen, Goonnapa Fucharoen, Arunee Jetsrisuparb, Worawan Chumpia
BACKGROUND: Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia. This study aims to examine phosphatidylserine (PS) levels, platelet activation, and coagulation markers in splenectomized (S) and nonsplenectomy (NS) patients with hemoglobin (Hb) H disease...
January 18, 2018: Acta Haematologica
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