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Respiration; International Review of Thoracic Diseases

Jorrit B A Welling, Jorine E Hartman, Nick H T Ten Hacken, Ina Franz, Jean-Paul Charbonnier, Eva M van Rikxoort, Huib A M Kerstjens, Karin Klooster, Dirk-Jan Slebos
BACKGROUND: Absence of interlobar collateral ventilation using the Chartis measurement is the key predictor for successful endobronchial valve treatment in severe emphysema. Chartis was originally validated in spontaneous breathing patients under conscious sedation (CS); however, this can be challenging due to cough, mucus secretion, mucosal swelling, and bronchoconstriction. Performing Chartis under general anesthesia (GA) avoids these problems and may result in an easier procedure with a higher success rate...
August 16, 2018: Respiration; International Review of Thoracic Diseases
Simone Scarlata, Damiana Mancini, Alice Laudisio, Augusto Benigni, Raffaele Antonelli Incalzi
BACKGROUND: Assessing diaphragm mobility is important to detect malfunctions or impending exhaustion and to evaluate the effects of many chest and abdominal conditions on respiratory mechanics. Amongst several imaging methods, ultrasonography represents the only noninvasive, nonionizing imaging technique widely available for the direct assessment of diaphragm excursion. OBJECTIVES: the aim of this study is to prospectively assess the supine diaphragmatic motion amplitude, intra- and inter-observer agreement, and anthropometric correlates of diaphragm motion variability, measured through M-mode ultrasonography, in a sample of healthy volunteers...
August 16, 2018: Respiration; International Review of Thoracic Diseases
Toby M Maher, Jeffrey J Swigris, Michael Kreuter, Marlies Wijsenbeek, Nicola Cassidy, Lucy Ireland, Judit Axmann, Steven D Nathan
BACKGROUND: Antifibrotics are recommended for the treatment of individuals with idiopathic pulmonary fibrosis (IPF), but treatment use remains at ∼60%. OBJECTIVE: To investigate the views of individuals with IPF and pulmonologists on the diagnosis and management of IPF to understand treatment patterns. METHODS: Interviews and/or online surveys were completed by patients and pulmonologists from Canada, France, Germany, Italy, Spain, and the UK...
August 16, 2018: Respiration; International Review of Thoracic Diseases
David K Yoo, Maurizio Zompatori, Annapina Barrile, Giorgia Rossi, Dejanira D'Amato, Gianluigi Sergiacomi, Paola Rogliani, Marco Mura
BACKGROUND: Associated pulmonary hypertension (APH) is frequently observed in fibrosing interstitial pneumonias (FIP), such as idiopathic pulmonary fibrosis (IPF). APH is associated with worse prognosis, but it remains unclear whether it is associated with greater functional impairment. Six-minute walk distance (6MWD) is widely used to assess functional capacity in pulmonary hypertension and FIP. OBJECTIVES: To investigate if APH independently contributes to exercise intolerance in FIP, irrespective of the extent of underlying fibrosis...
August 16, 2018: Respiration; International Review of Thoracic Diseases
Annika W M Goorsenberg, Julia N S d'Hooghe, Daniel M de Bruin, Inge A H van den Berk, Jouke T Annema, Peter I Bonta
BACKGROUND: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. OBJECTIVE: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects of BT by OCT and compare these to the untreated right middle lobe (RML)...
August 15, 2018: Respiration; International Review of Thoracic Diseases
Michael Dreher, Ayham Daher, András Keszei, Nikolaus Marx, Tobias Müller, Christian Cornelissen, Vincent Brandenburg
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) often occur together. However, COPD is underdiagnosed among CHD patients. OBJECTIVES: This study investigated the prevalence of COPD and relevant pulmonary function test (PFT) impairments in patients with acute myocardial infarction (AMI). METHODS: Patients undergoing coronary angiography for AMI were prospectively included. Body plethysmography, lung diffusing capacity, blood gas analysis, and echocardiography were performed...
August 15, 2018: Respiration; International Review of Thoracic Diseases
Ales Rozman, Tony S K Mok
No abstract text is available yet for this article.
July 26, 2018: Respiration; International Review of Thoracic Diseases
Daniela Gompelmann, Vasiliki Gerovasili, Konstantina Kontogianni, Maren Schuhmann, Ralf Eberhardt, Felix J F Herth, Markus Polke
BACKGROUND: Valve implantation provides a reversible effective therapy in a selected group of emphysema patients. Knowing predictors for successful therapy, the rate of treatment failure has decreased. Some patients, however, do not benefit, so that the valves may have to be removed. OBJECTIVES: To assess implant-related events, complications during valve removal, and clinical outcome after endoscopic procedure. METHODS: The data of 76 consecutive emphysema patients who underwent valve removal > 6 months since implantation were collected...
July 24, 2018: Respiration; International Review of Thoracic Diseases
Sahajal Dhooria, Inderpaul Singh Sehgal, Nalini Gupta, Amanjit Bal, Kuruswamy Thurai Prasad, Ashutosh Nath Aggarwal, Babu Ram, Ritesh Agarwal
BACKGROUND: Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is the preferred modality for sampling intrathoracic lymph nodes in patients with suspected sarcoidosis. Whether the number of revolutions of the needle inside the lymph node while performing TBNA affects the diagnostic yield is unknown. OBJECTIVES: The aim of this paper was to compare the yield of different numbers of needle revolutions (10 vs. 20) during EBUS-TBNA in sarcoidosis...
July 24, 2018: Respiration; International Review of Thoracic Diseases
Pieter C Goeminne, Lowie E G W Vanfleteren
No abstract text is available yet for this article.
July 24, 2018: Respiration; International Review of Thoracic Diseases
Jost Schnell, Meinrad Beer, Stephan Eggeling, Wolfgang Gesierich, Jens Gottlieb, Felix J F Herth, Hans-Stefan Hofmann, Berthold Jany, Michael Kreuter, Julia Ley-Zaporozhan, Robert Scheubel, Thorsten Walles, Sebastian Wiesemann, Heinrich Worth, Erich Stoelben
In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery, in co-operation with the German Society for Pulmonology, the German Radiological Society, and the German Society of Internal Medicine has developed an S3 guideline on spontaneous pneumothorax and post-interventional pneumothorax moderated by the German Association of Scientific Medical Societies. METHOD: Based on the source guideline of the British Thoracic Society (2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards...
July 24, 2018: Respiration; International Review of Thoracic Diseases
Ana Rodrigo-Troyano, Valentina Melo, Pedro J Marcos, Elena Laserna, Meritxell Peiro, Guillermo Suarez-Cuartin, Lidia Perea, Anna Feliu, Vicente Plaza, Paola Faverio, Marcos I Restrepo, Antonio Anzueto, Oriol Sibila
BACKGROUND: Pseudomonas aeruginosa (PA) is a common microorganism related to severe exacerbations in Chronic Obstructive Pulmonary Disease (COPD). However, their role in COPD patients with frequent hospitalized exacerbations (FHE) is not well described. OBJECTIVES: We aimed to determine prevalence, risk factors, susceptibility patterns and impact on outcomes of PA in COPD patients with FHE. METHODS: Prospective observational multicentre study that included COPD patients with FHE...
July 24, 2018: Respiration; International Review of Thoracic Diseases
Paolo Spagnolo, Michael Kreuter, Toby M Maher, Wim Wuyts, Francesco Bonella, Tamera J Corte, Stefan Kopf, Derek Weycker, Klaus-Uwe Kirchgaessler, Christopher J Ryerson
BACKGROUND: Diabetes mellitus is a possible risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet the effect of antidiabetic therapy on the course of IPF is unknown. OBJECTIVES: This post hoc analysis assessed the effect of metformin on clinically relevant outcomes in patients with IPF. METHODS: For the primary analysis, patients randomized to placebo (n = 624) in 3 phase 3, double-blind, controlled trials of pirfenidone (CAPACITY [NCT00287716 and NCT00287729]; ASCEND [NCT01366209]) were categorized by baseline metformin use...
July 19, 2018: Respiration; International Review of Thoracic Diseases
Alberto M Marra, Robert Naeije, Francesco Ferrara, Olga Vriz, Anna Agnese Stanziola, Michele D'Alto, Antonello D'Andrea, Luca Carannante, Christina Alessandra Eichstaedt, Antonio Cittadini, Nicola Benjamin, Ekkehard Grünig, Eduardo Bossone
BACKGROUND: Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). OBJECTIVES: To explore the physiologic range of TRV in healthy adults and to investigate its clinical determinants. METHODS: In the first part of the study, 614 healthy individuals (age 45.7± 14.7 years, 60.26% women) were prospectively assessed by TTE...
July 18, 2018: Respiration; International Review of Thoracic Diseases
Ryan Kern, Kenneth Sakata, Steve G Peters, David Midthun, John Mullon, Eric Edell
Airway complications after lung transplant occur in approximately 10-15% of the recipients and often occur at the anastomosis, largely due to ischemia. To decrease anastomotic ischemia, surgeons minimize the length of the donor bronchus. However, a shortened donor bronchus creates technical challenges if a stent is required to treat an airway complication. We present a case of a lung transplant recipient with the combination of left main stem bronchial malacia and a triad of severe strictures at the left anastomosis, entrance to the left upper lobe, and left lower lobe...
July 17, 2018: Respiration; International Review of Thoracic Diseases
Horiana B Grosu, Farah Kazzaz, Erik Vakil, Sofia Molina, David Ost
BACKGROUND: Thoracentesis with cytological examination of pleural fluid is the initial test of choice for evaluation of pleural effusions in patients with suspected malignant pleural effusion (MPE). There is limited data on the sensitivity of thoracentesis stratified by tumor type. A better understanding of stratified sensitivities is of clinical interest, and may guide early and appropriate referral for pleural biopsy. OBJECTIVE: The primary objective was sensitivity of thoracentesis with pleural fluid cytology stratified by tumor type...
July 17, 2018: Respiration; International Review of Thoracic Diseases
Argyrios Tzouvelekis, Vasilios Tzilas, Maria Dassiou, Demosthenes Bouros
No abstract text is available yet for this article.
July 13, 2018: Respiration; International Review of Thoracic Diseases
Boris Melloni, Line Mounier, Jean-Pierre Laaban, Arnaud Chambellan, Didier Foret, Jean-François Muir
BACKGROUND: The aetiologies of chronic respiratory failure (CRF) are moving in many western countries. Obesity-Hypoventilation syndrome (OHS) has become one of the most common indications of non-invasive ventilation (NIV) with Chronic Obstructive Pulmonary Diseases (COPD). Long-Term Oxygen Therapy (LTOT) technology is the treatment plan for CRF patients in the new era. OBJECTIVES: This study aimed to assess home-based care evolution in CRF patients on LTOT (LTOT) and/or NIV from the ANTADIR observatory...
July 13, 2018: Respiration; International Review of Thoracic Diseases
Christoph Sinning, Lars Harbaum, Benedikt Schrage, Nicole Rübsamen, Christina Magnussen, Benjamin Waschki, Wilko H Kleemann, Kaaja M Baaske, Maria Kögler, Francisco Ojeda, Christine Fischer, Nicola Benjamin, Dirk Westermann, Elvin Zengin, Ulrich Schäfer, Benjamin Egenlauf, Hans F Klose, Stefan Blankenberg, Ekkehard Grünig
BACKGROUND: Right ventricular (RV) dysfunction is a major prognostic predictor in pulmonary arterial hypertension (PAH). OBJECTIVES: The objective of this study was to assess the prognostic impact of a newly developed index merging haemodynamic parameters into 1 variable. METHODS: We retrospectively assessed 2 cohorts of 248 patients (164 from Hamburg and 84 from Heidelberg) with invasively diagnosed PAH. During a median follow-up time of 3...
July 12, 2018: Respiration; International Review of Thoracic Diseases
David de la Rosa Carrillo, Annie Navarro Rolon, Rosa Maria Girón Moreno, Beatriz Montull Veiga, Casilda Olveira Fuster, Alicia Padilla Galo, Concepción Prados Sánchez, Esther Quintana Gallego, Oriol Sibila Vidal, Nuria Celorrio Jiménez, Antonio Ruiz Peña, Antoni Torres Martí, Maria Jesús Avilés Inglés, Marina Blanco Aparicio, Marta García-Clemente, Rafael Golpe Gómez, Ainhoa Gómez Bonilla, Cristina Gómez González, Maria Victoria Leal Arranz, Patricia Mínguez Clemente, Belén López Muñiz, Luis Máiz Carro, Ana Pando Sandoval, Juan Luis Rodríguez Hermosa, Ane Uranga Echeverria, Ana Núñez Ares, Lorena López Roldán, Carmen Abellán Martínez, Abel Jesús Martínez García, Francisco Javier Michel de la Rosa, Raúl Godoy Mayoral, Miguel Ángel Martínez-García
BACKGROUND: Knowing the cost of hospitalizations for exacerbation in bronchiectasis patients is essential to perform cost-effectiveness studies of treatments that aim to reduce exacerbations in these patients. OBJECTIVES: To find out the mean cost of hospitalizations due to exacerbations in bronchiectasis patients, and to identify factors associated with higher costs. METHODS: Prospective, observational, multicenter study in adult bronchiectasis patients hospitalized due to exacerbation...
July 11, 2018: Respiration; International Review of Thoracic Diseases
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