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Respiration; International Review of Thoracic Diseases

Elisabeth Bendstrup, Wim Wuyts, Tiago Alfaro, Nazia Chaudhuri, Robin Cornelissen, Michael Kreuter, Kirsten Melgaard Nielsen, Anna-Marie B Münster, Marjukka Myllärniemi, Claudia Ravaglia, Tim Vanuytsel, Marlies Wijsenbeek
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. In general, making clear evidence-based decisions can be difficult for physicians because patients with comorbidities are often excluded from clinical trials...
December 13, 2018: Respiration; International Review of Thoracic Diseases
Michael A Mitchell, Pen Li, Christopher Pease, Sarah Hosseini, Carolina Souza, Tinghua Zhang, Kayvan Amjadi
BACKGROUND: Use of indwelling pleural catheters (IPCs) for the management of symptomatic pleural effusions in patients with mesothelioma has increased in popularity. An important concern with this approach is the potential for the development of catheter tract metastasis (CTM). OBJECTIVES: To determine the incidence of IPC-related CTM in patients with malignant pleural mesothelioma (MPM). METHODS: In this single-center retrospective cohort study, patients with biopsy-confirmed MPM who had an IPC inserted between May 2006 and July 2017 were identified from a prospectively collected database...
December 13, 2018: Respiration; International Review of Thoracic Diseases
Meng-Jiao Xu, Bing Dai, Yun Peng, Jia Su, Wei Tan, Hong-Wen Zhao
BACKGROUND: Most of the patients on noninvasive positive pressure ventilation require aerosol inhalation therapy to moisturize the airways or deliver drugs in acute settings. However, the effect of jet nebulization on noninvasive positive pressure ventilation (NPPV) has not been determined. OBJECTIVES: This study was designed to investigate the impact of jet nebulization on NPPV applied in ventilators. METHODS: Aerosol therapy during NPPV was conducted in a simulated lung...
December 13, 2018: Respiration; International Review of Thoracic Diseases
Felix J F Herth, Stephan Sorichter, Gerard J Criner
No abstract text is available yet for this article.
December 12, 2018: Respiration; International Review of Thoracic Diseases
Motoyasu Kato, Shinichi Sasaki, Kana Kurokawa, Takahiro Nakamura, Tomoko Yamada, Hitoshi Sasano, Naoko Arano, Moegi Komura, Hiroaki Ihara, Osamu Nagashima, Satomi Shiota, Fumiyuki Takahashi, Kazuhisa Takahashi
BACKGROUND: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare interstitial pneumonia that is characterized by stiffness in both the upper lobes and pleura, which is evident on high resolution computed tomography (HRCT) of the chest. However, prognostic factors for IPPFE have not been identified yet. OBJECTIVE: We aimed to investigate the clinical prognostic factors affecting survival in patients with IPPFE. METHODS: Between April 2009 and September 2017, we enrolled 36 patients who were clinically diagnosed with IPPFE, using HRCT...
December 6, 2018: Respiration; International Review of Thoracic Diseases
Anna S Stöberl, Thomas Gaisl, Cecilia Giunta, Noriane A Sievi, Florian Singer, Alexander Möller, Marianne Rohrbach, Malcolm Kohler
BACKGROUND: In Ehlers-Danlos syndrome (EDS), a group of monogenic disorders affecting connective tissues, obstructive sleep apnoea (OSA) is highly prevalent in adults. The prevalence of OSA in children with EDS is unknown. OBJECTIVES: This prospective cross-sectional study aimed at determining the prevalence of OSA in paediatric EDS patients. METHODS: Children with EDS (n = 24) were recruited from the Children's Hospital Zurich and matched to healthy controls...
November 28, 2018: Respiration; International Review of Thoracic Diseases
Carlos Antonio Amado, Maria Teresa García-Unzueta, Bernardo Alio Lavin, Armando Raúl Guerra, Juan Agüero, Laura Ramos, Pedro Muñoz
BACKGROUND: In chronic obstructive pulmonary disease (COPD), low muscle mass has been associated with several clinical outcomes such as low exercise capacity, hospital admission, and mortality. The Sarcopenia Index (SI) is a novel way to estimate muscle mass based on the ratio of serum creatinine (produced exclusively by muscle)/cystatin C (produced by all nucleated body cells). OBJECTIVES: This study aims to assess the SI in stable COPD outpatients, as compared with a healthy control group, to quantify its relationship with several important clinical features in COPD, and to study its potential usefulness to predict COPD exacerbations and hospital admissions...
November 27, 2018: Respiration; International Review of Thoracic Diseases
Pham Anh Hong Nguyen, Piet Vercauter, Luc Verbeke, Roel Beelen, Christophe Dooms, Kurt G Tournoy
BACKGROUND: In patients with locally advanced lung cancer treated with concurrent chemoradiation, outcome measurements have been mostly limited to survival. OBJECTIVES: We aimed to measure outcomes that matter to these patients beyond survival in a general clinical practice. METHODS: In a prospective single-centre study, consecutive patients with locally advanced non-small cell lung cancer reported their own outcomes using the EORTC Quality of Life Questionnaire Core 30 at baseline, during therapy, at therapy stop and till 1 year after therapy end every 3 months...
November 22, 2018: Respiration; International Review of Thoracic Diseases
Sabina A Guler, Manuela Funke-Chambour
No abstract text is available yet for this article.
November 19, 2018: Respiration; International Review of Thoracic Diseases
Srinivas Rajagopala
No abstract text is available yet for this article.
November 14, 2018: Respiration; International Review of Thoracic Diseases
Lizzy Wijmans, Peter I Bonta, Rita Rocha-Pinto, Daniel M de Bruin, Paul Brinkman, René E Jonkers, Joris J T H Roelofs, Venerino Poletti, Jürgen Hetzel, Jouke T Annema
BACKGROUND: Transbronchial cryobiopsy (TBCB) of the lung parenchyma is a minimally invasive alternative for surgical lung biopsy in interstitial lung disease (ILD) patients. Drawbacks are the nondiagnostic rate and complication risk of pneumothorax and bleeding. Fluoroscopy is the current guidance tool for TBCB, which is limited by 2D imaging and a radiation dose for the patient. Confocal laser endomicroscopy (CLE) is a high-resolution imaging technique that provides immediate feedback during bronchoscopy about the elastin fiber network of peripheral lung areas...
November 14, 2018: Respiration; International Review of Thoracic Diseases
Dan Adler, Jean-Paul Janssens
The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved vary according to the underlying pathology, but respiratory failure is most often the result of an imbalance between the muscular pump and the mechanical load placed upon it. Changes in respiratory drive and response to CO2 seem to be important contributors to the pathophysiology of respiratory failure. Inspiratory muscle dysfunction is also frequent but is not a mandatory prerequisite to respiratory failure since increased load may also be sufficient to precipitate it...
November 13, 2018: Respiration; International Review of Thoracic Diseases
Ronen Brenner, Shaye Kivity, Marina Peker, Daniel Reinhorn, Lital Keinan-Boker, Barbara Silverman, Irena Liphsitz, Tamara Kolitz, Carmit Levy, Dekel Shlomi, Giora Pillar, Nir Peled
BACKGROUND: Several studies in animal models and human with obstructive sleep apnea syndrome (OSAS) demonstrated an increase in cancer aggressiveness and mortality. However, there is a need for further clinical evidence supporting a correlation between OSAS and cancer incidence. OBJECTIVES: To reveal whether OSAS presence and severity is correlated with cancer incidence in a large homogenous patients' cohort. METHODS: We analyzed a cohort of over 5,000 concurrently enrolled patients, age > 18, with suspected OSAS, from a tertiary medical academic center...
November 12, 2018: Respiration; International Review of Thoracic Diseases
Andrea Radine, Claudius Werner, Johanna Raidt, Gerard W Dougherty, Laura Kerschke, Heymut Omran, Joerg Grosse-Onnebrink
BACKGROUND: Cough is a key symptom in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). OBJECTIVE: The study objectives were to test whether cough is related to parameters reflecting their disease severity and whether CF and PCD differ in cough frequency. METHODS: In this prospective observational study, we used a microphone-based monitoring system (LEOSound® Monitor) to count the coughs in healthy subjects (HS) and in stable patients with CF and PCD (25 subjects per group) on 2 consecutive nights...
November 8, 2018: Respiration; International Review of Thoracic Diseases
Yoshihisa Hiraishi, Taisuke Jo, Nobuaki Michihata, Wakae Hasegawa, Yukiyo Sakamoto, Hirokazu Urushiyama, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase, Hideo Yasunaga, Yasuhiro Yamauchi
BACKGROUND: Recent advances in bronchoscopy utilizing endobronchial ultrasound (EBUS) as well as lung cancer therapy may have driven physicians to perform diagnostic bronchoscopy (DB) for high-risk patients. OBJECTIVES: The aim of this study was to clarify the relationship between hospital volume (HV) and outcomes of DB. METHODS: We collected data on inpatients with lung cancer who underwent DB from July 2010 to March 31, 2014. The annual HV of DB was classified as "very low" (≤50 cases/year), "low" (51-100 cases/year), "high" (101-300 cases/year), or "very high" (> 300 cases/year)...
November 8, 2018: Respiration; International Review of Thoracic Diseases
Yishi Li, Jinyue Jiang, Felix J F Herth, Tao Wan, Rui Zhang, Meiling Xiao, Xingxing Jin, Yang Xiao, Shuliang Guo
Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea is very rare and is easily misdiagnosed as a bronchogenic carcinoma or benign tracheal tumor. Here, we report a clinical case where a new clinical approach involving a water-jet hybrid knife was employed in the diagnosis and treatment of primary tracheal MALT lymphoma.
November 8, 2018: Respiration; International Review of Thoracic Diseases
Pia Iben Pietersen, Lars Konge, Ole Graumann, Bjørn Ulrik Nielsen, Christian B Laursen
BACKGROUND: Clinical lung ultrasound (LUS) is a fast bedside diagnostic tool which can assist clinicians in decisions regarding the treatment and monitoring of patients with respiratory symptoms. LUS training and education differ widely, and is often done in a clinical setting, with potential risks for patients if decisions are made based on the wrong interpretations. No clear guidelines or recommendations for objective and standardized assessment of LUS skills exist, and those that do are often based on a fixed time-frame or an arbitrary number of examinations performed; this does not ensure adequate competencies...
November 7, 2018: Respiration; International Review of Thoracic Diseases
Guido Domenighetti
No abstract text is available yet for this article.
November 7, 2018: Respiration; International Review of Thoracic Diseases
Kristoffer Mazanti Cold, Lars Konge, Paul Frost Clementsen, Leizl Joy Nayahangan
BACKGROUND: Several studies have shown the beneficial effects of mastery learning of a simulation-based course, but not all trainees complete it. OBJECTIVES: The purpose of this study was to find deciding factors for the completion of a simulation-based mastery learning course with distributive practice in flexible bronchoscopy. METHODS: Seventy-seven trainees who signed up for the course were invited to a survey for deciding factors of completing the course...
November 2, 2018: Respiration; International Review of Thoracic Diseases
Adrian Gillissen, Christian Gessner, Klaus Hechenbichler, Felix J F Herth, Ralf Juenemann, Frank Kanniess, Peter Kardos, Marek Lommatzsch, Regina Schneidereit, Wolfram Windisch
BACKGROUND: The fixed-dose combination of budesonide/formoterol (B/F) has been available in the Spiromax® dry powder inhaler since 2014. OBJECTIVES: To assess patient satisfaction, inhaler use errors, and disease control in patients with asthma or chronic obstructive pulmonary disease (COPD) treated with B/F Spiromax. METHODS: This non-interventional, prospective, 12-week study enrolled consecutive asthma or COPD patients who had recently begun treatment with B/F Spiromax or were switched from another inhaled corticosteroid/long-acting β2-agonist combination to B/F Spiromax in routine clinical practice...
November 2, 2018: Respiration; International Review of Thoracic Diseases
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