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Respiration; International Review of Thoracic Diseases

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https://www.readbyqxmd.com/read/29680830/pulmonary-perfusion-using-intrabronchial-capnography-in-pulmonary-artery-stenosis
#1
Hiroki Nishine, Hiromi Muraoka, Takeo Inoue, Teruomi Miyazawa, Masamichi Mineshita
Stenting at the flow-limiting segment can improve the ventilation-perfusion ratio in patients with central airway stenosis. However, there is no quantitative examination for assessing the perfusion status during interventional bronchoscopy. Intrabronchial capnography can estimate regional gas exchange by measuring carbon dioxide concentration. We herein report a case of bilateral bronchial stenosis where stenting was able to improve ventilation-perfusion ratio using intrabronchial capnography. A 44-year-old man was admitted to our institution with orthopnea...
April 20, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29669351/bronchial-thermoplasty-in-severe-asthma-best-practice-recommendations-from-an-expert-panel
#2
Peter I Bonta, Pascal Chanez, Jouke T Annema, Pallav L Shah, Robert Niven
Bronchial thermoplasty (BT) is a bronchoscopic treatment for patients with severe asthma who remain symptomatic despite optimal medical therapy. In this "expert best practice" paper, the background and practical aspects of BT are highlighted. Randomized, controlled clinical trials have shown BT to be safe and effective in reducing severe exacerbations, improving quality of life, and decreasing emergency department visits. Five-year follow-up studies have provided evidence of the functional stability of BT-treated patients with persistence of a clinical benefit...
April 17, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29656288/progress-in-interventional-pulmonology
#3
Pallav L Shah, Felix J F Herth
No abstract text is available yet for this article.
April 13, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29642071/risk-factor-profiles-achieved-with-medical-therapy-in-prevalent-patients-with-pulmonary-arterial-and-distal-chronic-thromboembolic-pulmonary-hypertension
#4
Philipp Bartenstein, Stéphanie Saxer, Paula Appenzeller, Mona Lichtblau, Esther I Schwarz, Silvia Ulrich
BACKGROUND: The latest pulmonary hypertension (PH) guidelines define therapeutic goals in terms of symptoms, exercise capacity, and haemodynamics for patients with pulmonary arterial hypertension (PAH) and recommend advanced combined medical therapy. For inoperable or post-surgical residual distal chronic thromboembolic PH (CTEPH) medical treatment is similarly advised. OBJECTIVES: We analysed whether risk factor goals are achieved and combination therapy is used in prevalent patients with PAH or distal CTEPH...
April 11, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29635251/clinical-diagnostic-and-treatment-disparities-between-hiv-infected-and-non-hiv-infected-immunocompromised-patients-with-pneumocystis-jirovecii-pneumonia
#5
Helmut J F Salzer, Guido Schäfer, Martin Hoenigl, Gunar Günther, Christian Hoffmann, Barbara Kalsdorf, Alexandre Alanio, Christoph Lange
The substantial decline in the Pneumocystis jirovecii pneumonia (PCP) incidence in HIV-infected patients after the introduction of antiretroviral therapy (ART) in resource-rich settings and the growing number of non-HIV-infected immunocompromised patients at risk leads to considerable epidemiologic changes with clinical, diagnostic, and treatment consequences for physicians. HIV-infected patients usually develop a subacute course of disease, while non-HIV-infected immunocompromised patients are characterized by a rapid disease progression with higher risk of respiratory failure and higher mortality...
April 10, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29621778/dermal-filler-injections-mimic-tumor-activity-during-immune-checkpoint-inhibition
#6
Zulfiya Syunyaeva, Kathrin Kahnert, Diego Kauffmann-Guerrero, Rudolf Maria Huber, Amanda Tufman
No abstract text is available yet for this article.
April 5, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29621756/experience-with-transcordal-silicone-stents-in-adult-laryngotracheal-stenosis-a-bicentric-retrospective-study
#7
Valerian Bourinet, Thibaut Raguin, Marc Fortin, Elsa Chetrit, Julien Guinde, Sophie Laroumagne, Nicolas Fakhry, Philippe Astoul, Christian Debry, Hervé Dutau
BACKGROUND: Benign stenosis involving laryngeal and upper tracheal structures represents a therapeutic challenge. Open surgery and endoscopic management have to be discussed by a multidisciplinary board in order to evaluate the risk and benefit for each patient. OBJECTIVE: The objective of this retrospective study was to report the experience of two French centers with transcordal silicone stents (TSS) in the endoscopic management of benign laryngotracheal stenosis (BLTS) in adults, with focus on efficacy, safety, and tolerability...
April 5, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29614508/diagnosis-and-management-of-asthma-the-swiss-guidelines
#8
Thomas Rothe, Paolo Spagnolo, Pierre-Olivier Bridevaux, Christian Clarenbach, Christine Eich-Wanger, Franca Meyer, David Miedinger, Alexander Möller, Laurent P Nicod, Geneviève Nicolet-Chatelain, Alain Sauty, Claudia Steurer-Stey, Joerg D Leuppi
The Global Initiative for Asthma (GINA) is a network of individuals, organizations, and public health officials that was established to disseminate information about the care of patients with asthma and to improve asthma care. The GINA ("Global Strategy for Asthma Management and Prevention") report has been updated annually since 2002. Due to new knowledge and therapeutic development in the field, the Swiss Respiratory Society felt the need to provide a new document that is based on both the available literature and the recommendations of the 2016 GINA report...
April 3, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29587299/chronic-obstructive-pulmonary-disease-in-lung-cancer-patients-prevalence-underdiagnosis-and-clinical-characterization
#9
Cecilia Mouronte-Roibás, Virginia Leiro-Fernández, Alberto Ruano-Raviña, Cristina Ramos-Hernández, José Abal-Arca, Isaura Parente-Lamelas, Maribel Botana-Rial, Ana Priegue-Carrera, Alberto Fernández-Villar
BACKGROUND: Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are associated with increased morbidity and mortality. The differential clinical and functional features among LC patients with or without COPD have not been defined. OBJECTIVES: The aims of this study were to examine the prevalence and underdiagnosis rate of COPD in LC patients and to compare the clinical and functional features of LC patients with and without COPD. METHODS: We designed a multicenter hospital-based study including all LC cases diagnosed from January 2014 to August 2016...
March 27, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29587297/a-prospective-trial-of-nebulized-amikacin-in-the-treatment-of-bronchiectasis-exacerbation
#10
Yirepanjaing Ailiyaer, Xiuxiu Wang, Yan Zhang, Caiyu Li, Tao Li, Qian Qi, Yu Li
BACKGROUND: Pseudomonas aeruginosa is the most common pathogenic bacteria in bronchiectasis (BE) patients. The availability and security of nebulized amikacin treatment are unknown. OBJECTIVE: The purpose of this study was to explore the efficiency and adverse effects of nebulized amikacin treatment for 2 weeks, administered as intravenous therapy during exacerbation of BE patients infected with P. aeruginosa. METHODS: A total of 143 patients with exacerbation of BE were screened between January 2013 and March 2016 at five tertiary hospitals in Shandong Province, China...
March 27, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29587263/a-real-life-multicenter-national-study-on-nintedanib-in-severe-idiopathic-pulmonary-fibrosis
#11
Sergio Harari, Antonella Caminati, Venerino Poletti, Marco Confalonieri, Stefano Gasparini, Donato Lacedonia, Fabrizio Luppi, Alberto Pesci, Alfredo Sebastiani, Paolo Spagnolo, Carlo Vancheri, Elisabetta Balestro, Martina Bonifazi, Stefania Cerri, Federica De Giacomi, Rossana Della Porta, Maria Pia Foschino Barbaro, Annalisa Fui, Patrizio Pasquinelli, Roberta Rosso, Sara Tomassetti, Claudia Specchia, Paola Rottoli
BACKGROUND: Two therapeutic options are currently available for patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. To date, there is still insufficient data on the efficacy of these 2 agents in patients with more severe disease. OBJECTIVES: This national, multicenter, retrospective real-life study was intended to determine the impact of nintedanib on the treatment of patients with severe IPF. METHODS: All patients included had severe IPF and had to have at least 6 months of follow-up before and at least 6 months of follow-up after starting nintedanib...
March 27, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29539607/copd-patients-requiring-long-term-niv-therapy-what-are-the-critical-points-in-monitoring-the-efficacy-of-niv
#12
Eylem Tuncay, Antonio M Esquinas
No abstract text is available yet for this article.
March 14, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29539604/diagnostic-accuracy-of-interleukin-27-between-tuberculous-pleural-effusion-and-malignant-pleural-effusion-a-meta-analysis
#13
Qing Liu, Yan-Xia Yu, Xiao-Juan Wang, Zheng Wang, Zhen Wang
BACKGROUND: The concentration assay of pleural effusion interleukin-27 (IL-27) has raised concern for diagnosing tuberculous pleurisy. Compared with malignant pleural effusion (MPE), the concentration of IL-27 in tuberculous pleural effusion (TPE) increased significantly. Accurate differentiating diagnosis is essential for choosing treatment for pleural effusion. OBJECTIVE: The present meta-analysis is aimed at determining the accuracy of IL-27 in the differential diagnosis between TPE and MPE...
March 14, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29514162/design-rationale-methodology-and-aims-of-a-greek-prospective-idiopathic-pulmonary-fibrosis-registry-investigating-idiopathic-pulmonary-fibrosis-in-greece-indulge-ipf
#14
Demosthenes Bouros, Zoe Daniil, Despoina Papakosta, Katerina M Antoniou, Katerina Markopoulou, Likurgos Kolilekas, George Konstantopoulos, Spyros Papiris
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrosing interstitial pneumonia of unknown origin. Despite the fact that the guidelines on the diagnosis and management of the disease were updated in 2015, incorporating novel agents recently introduced in the therapeutic approach of IPF, there is a lack of data on the epidemiology, disease status, and treatment in clinical practice. Contemporary data provided by national registries in IPF provide valuable information to guide clinical management of the disease in the real-world setting, adjusted to the local needs...
March 7, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29502125/exercise-performance-of-lowlanders-with-copd-at-2-590-m-data-from-a-randomized-trial
#15
Michael Furian, Sara E Hartmann, Tsogyal D Latshang, Deborah Flueck, Christian Murer, Philipp M Scheiwiller, Batyr Osmonov, Silvia Ulrich, Malcolm Kohler, Marc J Poulin, Konrad E Bloch
BACKGROUND: Effects of hypobaric hypoxia at altitude on exercise performance of lowlanders with chronic obstructive pulmonary disease (COPD) have not been studied in detail. OBJECTIVES: To quantify changes in exercise performance and associated physiologic responses in lowlanders with COPD travelling to moderate altitude. METHODS: A total of 31 COPD patients with a median age (quartiles) of 66 years (59; 69) and FEV1 of 56% predicted (49; 69) living below 800 m performed a constant-load bicycle exercise to exhaustion at 60% of the maximal work rate at 490 m (Zurich) and at an identical work rate at 2,590 m (Davos) in randomized order...
March 2, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29490307/real-world-experience-with-nintedanib-in-patients-with-idiopathic-pulmonary-fibrosis
#16
Eva Brunnemer, Julia Wälscher, Svenja Tenenbaum, Julia Hausmanns, Karen Schulze, Marianne Seiter, Claus Peter Heussel, Arne Warth, Felix J F Herth, Michael Kreuter
BACKGROUND: Nintedanib, an oral tyrosine kinase inhibitor, has been shown to slow down the progression of idiopathic pulmonary fibrosis (IPF) in two randomised placebo-controlled trials by reducing the annual decline in forced vital capacity (FVC). However, real-world experience is limited. OBJECTIVE: To assess the efficacy and safety of nintedanib in a large cohort of patients treated at a tertiary referral site for interstitial lung diseases. METHODS: The records of patients with a confirmed diagnosis of IPF were reviewed...
February 28, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29486478/short-term-effects-of-a-multimodal-3-week-inpatient-pulmonary-rehabilitation-programme-for-patients-with-sarcoidosis-the-prokasare-study
#17
Heidrun Lingner, Heike Buhr-Schinner, Stefan Hummel, Jochen van der Meyden, Anika Grosshennig, Daniel Nowik, Konrad Schultz
BACKGROUND: Real-world data on the effects of a multicomponent pulmonary rehabilitation (PR) for patients with sarcoidosis are scarce. OBJECTIVE: To describe characteristics of patients with sarcoidosis referred for a 3-week inpatient PR, to assess the effects of PR on their quality of life (QoL) and clinical outcomes, and to investigate whether there are specific subgroups who particularly benefit from PR. METHODS: Using a prospective multicentre study design, data regarding 6-min walking distance (6MWD), QoL (Saint George's Respiratory Questionnaire, SGRQ), and the secondary outcomes of dyspnoea and psychological burden (fatigue, anxiety, and depression) were collected...
February 27, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29462808/bronchial-carcinoid-interventional-pulmonologist-first
#18
Erik H F M van der Heijden
No abstract text is available yet for this article.
February 20, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29455195/sildenafil-bosentan-drug-drug-interaction-a-word-of-caution-regarding-the-most-common-combination-therapy-in-children-with-advanced-pulmonary-arterial-hypertension
#19
Christian Apitz, Dietmar Schranz
No abstract text is available yet for this article.
February 16, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29444521/non-answered-questions-in-patients-with-endobronchial-valve-placement-for-lung-volume-reduction
#20
Iván R Caviedes, Gonzalo Labarca, Hugo G de Oliveira, Felix J F Herth, Sebastián Fernandez-Bussy
Endoscopic lung volume reduction is a minimally invasive procedure performed to reduce the space occupied by the emphysemas' lobes. This procedure has been demonstrated to be beneficial for patients with advanced chronic obstructive pulmonary disease and severe hyperinflation. The use of endobronchial valves is increasing, as well as the number of reports of adverse events. The most common complications after the procedure are a pneumothorax, bleeding, infections, the need for valve removal, and valve expulsion...
February 14, 2018: Respiration; International Review of Thoracic Diseases
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