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Respiration; International Review of Thoracic Diseases

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https://www.readbyqxmd.com/read/29212083/which-nebulizer-position-should-be-avoided-an-extended-study-of-aerosol-delivery-and-ventilator-performance-during-noninvasive-positive-pressure-ventilation
#1
Yun Peng, Bing Dai, Chun-Xiang Hu, Jia Su, Wei Tan, Hong-Wen Zhao, Jian Kang
BACKGROUND: Research on the effect of nebulizer location on aerosol delivery during noninvasive ventilation has reached inconsistent conclusions. OBJECTIVE: To investigate the effects of nebulizer position on aerosol delivery efficiency and ventilator performance during noninvasive ventilation. METHODS: The Active Servo Lung 5000 respiratory simulation system (ASL5000) was used to simulate a COPD patient. The noninvasive ventilator was set to the spontaneous breathing mode...
December 6, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29190621/nsclc-patients-harbouring-rare-or-complex-egfr-mutations-are-more-often-smokers-and-might-not-benefit-from-first-line-tyrosine-kinase-inhibitor-therapy
#2
Diego Kauffmann-Guerrero, Rudolf Maria Huber, Simone Reu, Amanda Tufman, Pontus Mertsch, Zulfiya Syunyaeva, Andreas Jung, Kathrin Kahnert
BACKGROUND: Generally, tyrosine kinase inhibitor (TKI) therapy is recommended in first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) harbouring a classic epidermal growth factor receptor (EGFR) mutation. However, the response of patients with rare or complex EGFR mutations to TKI treatment is not predictable, nor is the prognosis for such patients. OBJECTIVES: In cases of rare or complex EGFR mutations, the right approach to therapy remains challenging...
November 30, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29190612/assessment-of-bronchial-obstruction-using-lateral-pressure-measurement-during-bronchoscopy
#3
Hiroki Nishine, Takehiko Hiramoto, Takeo Inoue, Naoki Furuya, Hirotaka Kida, Hiroshi Handa, Seiichi Nobuyama, Masamichi Mineshita, Teruomi Miyazawa
BACKGROUND: In patients with bronchial obstruction estimating the location of the maximal obstruction is crucial for guiding interventional bronchoscopy. However, flow-volume curves cannot discriminate between the right and left lungs. OBJECTIVES: The aim of this study was to physiologically evaluate bronchial obstruction during interventional bronchoscopy. METHODS: We prospectively measured lateral airway pressure (Plat) at either side of the obstruction using a double-lumen catheter (pressure-pressure [P-P] curve) simultaneously to assess the degree of bronchial obstruction in 22 patients...
November 30, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29169165/giant-pseudoaneurysm-of-the-left-atrium-after-pneumonectomy
#4
Michael Westhoff, Ursula Kreppein
No abstract text is available yet for this article.
November 23, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29169162/application-of-electrocautery-needle-knife-combined-with-balloon-dilatation-versus-balloon-dilatation-in-the-treatment-of-tracheal-fibrotic-scar-stenosis
#5
Liyan Bo, Congcong Li, Min Chen, Deguang Mu, Faguang Jin
BACKGROUND: Electrocautery needle knives can largely reduce scar and granulation tissue hyperplasia and play an important role in treating patients with benign stricture. OBJECTIVE: The aim of this retrospective study was to evaluate the efficacy and safety of electrocautery needle knife combined with balloon dilatation versus balloon dilatation alone in the treatment of tracheal stenosis caused by tracheal intubation or tracheotomy. METHODS: We retrospectively analysed the clinical data of 43 patients with tracheal stenosis caused by tracheotomy or tracheal intubation in our department from January 2013 to January 2016...
November 23, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29169151/cystic-lung-disease-in-genetic-syndromes-with-deficient-tumor-suppressor-gene-function
#6
Cécile Daccord, Laurent P Nicod, Romain Lazor
Cystic lung diseases constitute a distinct group of rare lung disorders, among which two result from monogenic defects affecting tumor suppressor genes: lymphangioleiomyomatosis, either sporadic or associated with tuberous sclerosis complex, and Birt-Hogg-Dubé syndrome. These disorders have similarities in their clinical expression, including occurrence in young adults, multiple pulmonary cysts, recurrent pneumothorax, skin hamartomas, and renal tumors. However, they markedly differ in their gender distribution, pathogenesis, disease course, and prognosis...
November 23, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29161721/impact-of-nocturnal-noninvasive-ventilation-on-pulmonary-rehabilitation-in-patients-with-end-stage-lung-disease-awaiting-lung-transplantation
#7
Nikolaus Kneidinger, Rainer Gloeckl, Ursula Schönheit-Kenn, Katrin Milger, Wolfgang Hitzl, Jürgen Behr, Klaus Kenn
BACKGROUND: Pulmonary rehabilitation (PR) in patients awaiting lung transplantation is crucial to ensure a transplant benefit. However, PR in patients with end-stage lung disease treated with noninvasive ventilation (NIV) remains an area of uncertainty. OBJECTIVES: The aim of the study was to assess the potential benefit of PR in patients awaiting lung transplantation treated with NIV. METHODS: Patients awaiting lung transplantation who underwent comprehensive inpatient PR from 1998 to 2015 were retrospectively analyzed...
November 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131120/a-prospective-study-to-evaluate-a-diagnostic-algorithm-for-the-use-of-fluid-lymphocyte-subset-analysis-in-undiagnosed-unilateral-pleural-effusions
#8
Giles Dixon, Rahul Bhatnagar, Natalie Zahan-Evans, Amelia O Clive, Paul F Virgo, Mary T Brett, Sophie H Otton, Andrew R L Medford, Nick A Maskell
BACKGROUND: Haematological malignancy is an important cause of pleural effusion. Pleural effusions secondary to haematological malignancy are usually lymphocyte predominant. However, several other conditions such as carcinoma, tuberculosis, and chronic heart failure also cause lymphocytic effusions. Lymphocyte subset (LS) analysis may be a useful test to identify haematological malignancy in patients with lymphocytic effusions. However, research into their utility in pleural effusion diagnostic algorithms has not yet been published...
November 10, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131111/physical-activity-and-fatigue-in-patients-with-sarcoidosis
#9
Thomas Bahmer, Henrik Watz, Maria Develaska, Benjamin Waschki, Klaus F Rabe, Helgo Magnussen, Detlef Kirsten, Anne-Marie Kirsten
BACKGROUND: Little is known about physical activity in daily life among patients with sarcoidosis. Fatigue is a frequent and disabling symptom that might negatively affect physical activity levels. METHODS: In patients with sarcoidosis, we measured physical activity (steps per day) by accelerometry (SenseWear Armband) for 1 week. We assessed lung function (DLCO, FVC), exercise capacity (6-min walking distance [6MWD]), health-related quality of life (St George's Respiratory Questionnaire [SGRQ]), generic quality of life (12-Item Short-Form Health Survey [SF-12]), and fatigue (Multidimensional Fatigue Inventory [MFI-20])...
November 9, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131071/highly-selective-endothelin-1-receptor-a-inhibition-prevents-bleomycin-induced-pulmonary-inflammation-and-fibrosis-in-mice
#10
Nikolaos Manitsopoulos, Ioanna Nikitopoulou, Nikolaos A Maniatis, Christina Magkou, Anastasia Kotanidou, Stylianos E Orfanos
BACKGROUND: Pulmonary fibrosis is a chronic disease, which progressively leads to respiratory failure and ultimately death. Endothelin-1 (ET-1), a vasoconstrictor secreted by endothelial cells, promotes vasoconstriction by activation of its receptors A and B. OBJECTIVES: We addressed the role of highly selective ET-1 receptor A (ETA) inhibition in the pathogenesis of experimental pulmonary fibrosis by bleomycin (BLM). METHODS: BLM sulfate (2 U/mL) or saline was intratracheally administered to C57/Bl6 mice (4 groups; n = 5-11/group)...
November 9, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131136/malignant-pleural-effusions-mistletoe-spray-instead-of-talc-poudrage
#11
Jane A Shaw, Coenraad F N Koegelenberg
No abstract text is available yet for this article.
November 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131094/pleurodesis-using-mistletoe-extract-delivered-via-a-spray-catheter-during-semirigid-pleuroscopy-for-managing-symptomatic-malignant-pleural-effusion
#12
Jung Seop Eom, Hyo Yeong Ahn, Jeong Ha Mok, Geewon Lee, Eun-Jung Jo, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee
BACKGROUND: Talc poudrage during thoracoscopy is considered the standard procedure for patients with symptomatic malignant pleural effusion (MPE). Until now, no alternative technique other than talc poudrage for pleurodesis during medical thoracoscopy has been proposed. Liquid sclerosants, such as mistletoe extract, have been sprayed evenly into the pleural cavity during semirigid pleuroscopy for chemical pleurodesis. OBJECTIVE: We conducted a retrospective study using the database of semirigid pleuroscopy to identify the usefulness of pleurodesis using a mistletoe extract delivered via a spray catheter during semirigid pleuroscopy for symptomatic MPE...
November 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131057/unaided-smoking-cessation-in-healthy-employees
#13
Meryem Manis, Michael Tamm, Daiana Stolz
BACKGROUND: According to guidelines, behavioral and pharmacological assistance should be offered to all smokers willing to quit. However, a large proportion of ex-cigarette smokers are self-quitters. OBJECTIVES: To identify characteristics of long-term, unaided self-quitters, as compared to recurrent smokers among health care employees. METHODS: University hospital employees (n = 5,218) were addressed through a 17-question questionnaire inquiring about past and current smoking behavior...
November 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29156451/impact-of-stressful-life-events-on-patients-with-chronic-obstructive-pulmonary-disease
#14
Tsung Yu, Anja Frei, Gerben Ter Riet, Milo A Puhan
BACKGROUND: There is a general notion that stressful life events may cause mental and physical health problems. OBJECTIVES: We aimed to describe stressful life events reported by patients with chronic obstructive pulmonary disease (COPD) and to assess their impact on health outcomes and behaviors. METHODS: Two hundred and sixty-six primary care patients who participated in the ICE COLD ERIC cohort study were asked to document any stressful life events in the past 3 years...
November 1, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29080896/objective-endoscopic-measurements-of-central-airway-stenosis-a-pilot-study
#15
Debora Gil, Rosa Maria Ortiz, Carles Sánchez, Antoni Rosell
BACKGROUND: Endoscopic estimation of the degree of stenosis in central airway obstruction is subjective and highly variable. OBJECTIVE: To determine the benefits of using SENSA (System for Endoscopic Stenosis Assessment), an image-based computational software, for obtaining objective stenosis index (SI) measurements among a group of expert bronchoscopists and general pulmonologists. METHODS: A total of 7 expert bronchoscopists and 7 general pulmonologists were enrolled to validate SENSA usage...
October 28, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29045951/lifestyle-behaviors-and-clinical-outcomes-in-idiopathic-pulmonary-fibrosis
#16
Baruch Vainshelboim, Jose Oliveira, Shimon Izhakian, Avraham Unterman, Mordechai Reuven Kramer
BACKGROUND: Lifestyle behaviors are not well-characterized in idiopathic pulmonary fibrosis (IPF). OBJECTIVES: To assess the association between lifestyle behaviors and clinical outcomes in patients with IPF. METHODS: A total of 34 IPF patients (median age 68 years) were assessed for daily sitting and weekly walking times using the International Physical Activity Questionnaire by in-person interview at baseline, and they were followed up for up to 40 months...
October 19, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29045949/effectiveness-of-a-home-based-active-video-game-programme-in-young-cystic-fibrosis-patients
#17
Tamara Del Corral, Maria Àngels Cebrià I Iranzo, Ibai López-de-Uralde-Villanueva, Roberto Martínez-Alejos, Isabel Blanco, Jordi Vilaró
BACKGROUND: Exercise-based rehabilitation is already a part of cystic fibrosis (CF) treatment; however, patient adherence is low. OBJECTIVES: To assess the effectiveness of a home exercise programme using active video games (AVGs) as a training modality for children and adolescents with CF. METHODS: Thirty-nine children with CF were randomised to a control group (CG, n = 20, age 11 ± 6 years; FEV1 86.2 ± 20.5% of predicted) or a training group (AVGG, n = 19, age 13 ± 3 years; FEV1 82...
October 19, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29024926/metsovo-lung-a-story-of-episteme-techne-and-phronesis
#18
Vasilios Tzilas, Argyris Tzouvelekis, Demosthenes Bouros
No abstract text is available yet for this article.
October 13, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29020679/a-preclinical-evaluation-comparing-the-performance-of-a-novel-19-g-flexible-needle-to-a-commercially-available-22-g-ebus-tbna-sampling-needle
#19
Kasia Czarnecka-Kujawa, Alain Tremblay, Kazuhiro Yasufuku, Anna Sczaniecka, Sujeeth Parthiban, Lawrence Kunz, David Dillard, Xavier Gonzalez
BACKGROUND: Needle samples may not provide sufficient diagnostic material for the assessment of mediastinal lymph nodes. OBJECTIVE: The study compared the specimen size and diagnostic performance of a new 19-G endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) needle to that of a standard 22-G EBUS-TBNA needle in a swine model of granulomatous lymphadenopathy. METHODS: Granulomatous inflammation was induced in mediastinal lymph nodes (LNs) of 10 domestic swine by injection of talc slurry...
October 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29020675/increased-platelet-monocyte-interaction-in-stable-copd-in-the-absence-of-platelet-hyper-reactivity
#20
Floor E Aleva, Godfrey Temba, Quirijn de Mast, Sami O Simons, Philip G de Groot, Yvonne F Heijdra, André J A M van der Ven
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is well known for its cardiovascular co-morbidities. Increased platelet-monocyte interaction is found in COPD and may reflect altered platelet function and a potential role for anti-platelet therapy. OBJECTIVES: The objectives were to investigate platelet-monocyte interaction, platelet activation and reactivity and plasmatic coagulation in stable COPD. METHODS: Platelet-monocyte interaction and platelet activation were determined by flow cytometry in 30 stable COPD patients and 25 controls...
October 12, 2017: Respiration; International Review of Thoracic Diseases
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